data_7ATD
# 
_entry.id   7ATD 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.339 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
PDB   7ATD         
WWPDB D_1292112052 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 7AT0 unspecified 
PDB . 7AT2 unspecified 
PDB . 7AT3 unspecified 
PDB . 7AT4 unspecified 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        7ATD 
_pdbx_database_status.recvd_initial_deposition_date   2020-10-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Miguel-Ruano, V.' 1 0000-0002-2492-7164 
'Rivera, I.'       2 0000-0002-4650-4605 
'Hermoso, J.A.'    3 0000-0002-1862-8950 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   NE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Comput Struct Biotechnol J' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2001-0370 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            19 
_citation.language                  ? 
_citation.page_first                1214 
_citation.page_last                 1232 
_citation.title                     
'Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family.' 
_citation.year                      2021 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.csbj.2021.01.047 
_citation.pdbx_database_id_PubMed   33680362 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Miguel-Ruano, V.'    1  ? 
primary 'Rivera, I.'          2  ? 
primary 'Rajkovic, J.'        3  ? 
primary 'Knapik, K.'          4  ? 
primary 'Torrado, A.'         5  ? 
primary 'Otero, J.M.'         6  ? 
primary 'Beneventi, E.'       7  ? 
primary 'Becerra, M.'         8  ? 
primary 'Sanchez-Costa, M.'   9  ? 
primary 'Hidalgo, A.'         10 ? 
primary 'Berenguer, J.'       11 ? 
primary 'Gonzalez-Siso, M.I.' 12 ? 
primary 'Cruces, J.'          13 ? 
primary 'Rua, M.L.'           14 ? 
primary 'Hermoso, J.A.'       15 ? 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     7ATD 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     47.846 
_cell.length_a_esd                 ? 
_cell.length_b                     80.243 
_cell.length_b_esd                 ? 
_cell.length_c                     145.146 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         7ATD 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'EstD11 S144A'          32170.012 2   ? ? ? ? 
2 non-polymer syn 'FORMIC ACID'           46.025    14  ? ? ? ? 
3 non-polymer syn 'ACETATE ION'           59.044    2   ? ? ? ? 
4 non-polymer syn 'Naproxen Methyl Ester' 244.286   1   ? ? ? ? 
5 water       nat water                   18.015    673 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MASEALTMIVNLLRSQRPLQEPTVEQMRAGLEAMAQMSPLPADVELTTVDAGGVPGAWVRVPESDPDRVVLYLHGGGYVI
GSIRTHRDLAQRIARAARCRVLLIDYRLAPEHPHPAAVEDSTRAYRWLLETGSDPKRMAIAGDAAGGGLTVATLVALRDA
GVPLPAAAVCLSPWVDLEGIGESMTTKAAVDPMVQREPLLRMASMYLAGQDPRTPLAAPLYADLRGLPPLLIQVGTAETL
LDDSVRLAERARAAGVQVTLEPWEDMIHVWQAFAAMLPEGQQAIERIGEFLRQHWQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MASEALTMIVNLLRSQRPLQEPTVEQMRAGLEAMAQMSPLPADVELTTVDAGGVPGAWVRVPESDPDRVVLYLHGGGYVI
GSIRTHRDLAQRIARAARCRVLLIDYRLAPEHPHPAAVEDSTRAYRWLLETGSDPKRMAIAGDAAGGGLTVATLVALRDA
GVPLPAAAVCLSPWVDLEGIGESMTTKAAVDPMVQREPLLRMASMYLAGQDPRTPLAAPLYADLRGLPPLLIQVGTAETL
LDDSVRLAERARAAGVQVTLEPWEDMIHVWQAFAAMLPEGQQAIERIGEFLRQHWQ
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   SER n 
1 4   GLU n 
1 5   ALA n 
1 6   LEU n 
1 7   THR n 
1 8   MET n 
1 9   ILE n 
1 10  VAL n 
1 11  ASN n 
1 12  LEU n 
1 13  LEU n 
1 14  ARG n 
1 15  SER n 
1 16  GLN n 
1 17  ARG n 
1 18  PRO n 
1 19  LEU n 
1 20  GLN n 
1 21  GLU n 
1 22  PRO n 
1 23  THR n 
1 24  VAL n 
1 25  GLU n 
1 26  GLN n 
1 27  MET n 
1 28  ARG n 
1 29  ALA n 
1 30  GLY n 
1 31  LEU n 
1 32  GLU n 
1 33  ALA n 
1 34  MET n 
1 35  ALA n 
1 36  GLN n 
1 37  MET n 
1 38  SER n 
1 39  PRO n 
1 40  LEU n 
1 41  PRO n 
1 42  ALA n 
1 43  ASP n 
1 44  VAL n 
1 45  GLU n 
1 46  LEU n 
1 47  THR n 
1 48  THR n 
1 49  VAL n 
1 50  ASP n 
1 51  ALA n 
1 52  GLY n 
1 53  GLY n 
1 54  VAL n 
1 55  PRO n 
1 56  GLY n 
1 57  ALA n 
1 58  TRP n 
1 59  VAL n 
1 60  ARG n 
1 61  VAL n 
1 62  PRO n 
1 63  GLU n 
1 64  SER n 
1 65  ASP n 
1 66  PRO n 
1 67  ASP n 
1 68  ARG n 
1 69  VAL n 
1 70  VAL n 
1 71  LEU n 
1 72  TYR n 
1 73  LEU n 
1 74  HIS n 
1 75  GLY n 
1 76  GLY n 
1 77  GLY n 
1 78  TYR n 
1 79  VAL n 
1 80  ILE n 
1 81  GLY n 
1 82  SER n 
1 83  ILE n 
1 84  ARG n 
1 85  THR n 
1 86  HIS n 
1 87  ARG n 
1 88  ASP n 
1 89  LEU n 
1 90  ALA n 
1 91  GLN n 
1 92  ARG n 
1 93  ILE n 
1 94  ALA n 
1 95  ARG n 
1 96  ALA n 
1 97  ALA n 
1 98  ARG n 
1 99  CYS n 
1 100 ARG n 
1 101 VAL n 
1 102 LEU n 
1 103 LEU n 
1 104 ILE n 
1 105 ASP n 
1 106 TYR n 
1 107 ARG n 
1 108 LEU n 
1 109 ALA n 
1 110 PRO n 
1 111 GLU n 
1 112 HIS n 
1 113 PRO n 
1 114 HIS n 
1 115 PRO n 
1 116 ALA n 
1 117 ALA n 
1 118 VAL n 
1 119 GLU n 
1 120 ASP n 
1 121 SER n 
1 122 THR n 
1 123 ARG n 
1 124 ALA n 
1 125 TYR n 
1 126 ARG n 
1 127 TRP n 
1 128 LEU n 
1 129 LEU n 
1 130 GLU n 
1 131 THR n 
1 132 GLY n 
1 133 SER n 
1 134 ASP n 
1 135 PRO n 
1 136 LYS n 
1 137 ARG n 
1 138 MET n 
1 139 ALA n 
1 140 ILE n 
1 141 ALA n 
1 142 GLY n 
1 143 ASP n 
1 144 ALA n 
1 145 ALA n 
1 146 GLY n 
1 147 GLY n 
1 148 GLY n 
1 149 LEU n 
1 150 THR n 
1 151 VAL n 
1 152 ALA n 
1 153 THR n 
1 154 LEU n 
1 155 VAL n 
1 156 ALA n 
1 157 LEU n 
1 158 ARG n 
1 159 ASP n 
1 160 ALA n 
1 161 GLY n 
1 162 VAL n 
1 163 PRO n 
1 164 LEU n 
1 165 PRO n 
1 166 ALA n 
1 167 ALA n 
1 168 ALA n 
1 169 VAL n 
1 170 CYS n 
1 171 LEU n 
1 172 SER n 
1 173 PRO n 
1 174 TRP n 
1 175 VAL n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ILE n 
1 181 GLY n 
1 182 GLU n 
1 183 SER n 
1 184 MET n 
1 185 THR n 
1 186 THR n 
1 187 LYS n 
1 188 ALA n 
1 189 ALA n 
1 190 VAL n 
1 191 ASP n 
1 192 PRO n 
1 193 MET n 
1 194 VAL n 
1 195 GLN n 
1 196 ARG n 
1 197 GLU n 
1 198 PRO n 
1 199 LEU n 
1 200 LEU n 
1 201 ARG n 
1 202 MET n 
1 203 ALA n 
1 204 SER n 
1 205 MET n 
1 206 TYR n 
1 207 LEU n 
1 208 ALA n 
1 209 GLY n 
1 210 GLN n 
1 211 ASP n 
1 212 PRO n 
1 213 ARG n 
1 214 THR n 
1 215 PRO n 
1 216 LEU n 
1 217 ALA n 
1 218 ALA n 
1 219 PRO n 
1 220 LEU n 
1 221 TYR n 
1 222 ALA n 
1 223 ASP n 
1 224 LEU n 
1 225 ARG n 
1 226 GLY n 
1 227 LEU n 
1 228 PRO n 
1 229 PRO n 
1 230 LEU n 
1 231 LEU n 
1 232 ILE n 
1 233 GLN n 
1 234 VAL n 
1 235 GLY n 
1 236 THR n 
1 237 ALA n 
1 238 GLU n 
1 239 THR n 
1 240 LEU n 
1 241 LEU n 
1 242 ASP n 
1 243 ASP n 
1 244 SER n 
1 245 VAL n 
1 246 ARG n 
1 247 LEU n 
1 248 ALA n 
1 249 GLU n 
1 250 ARG n 
1 251 ALA n 
1 252 ARG n 
1 253 ALA n 
1 254 ALA n 
1 255 GLY n 
1 256 VAL n 
1 257 GLN n 
1 258 VAL n 
1 259 THR n 
1 260 LEU n 
1 261 GLU n 
1 262 PRO n 
1 263 TRP n 
1 264 GLU n 
1 265 ASP n 
1 266 MET n 
1 267 ILE n 
1 268 HIS n 
1 269 VAL n 
1 270 TRP n 
1 271 GLN n 
1 272 ALA n 
1 273 PHE n 
1 274 ALA n 
1 275 ALA n 
1 276 MET n 
1 277 LEU n 
1 278 PRO n 
1 279 GLU n 
1 280 GLY n 
1 281 GLN n 
1 282 GLN n 
1 283 ALA n 
1 284 ILE n 
1 285 GLU n 
1 286 ARG n 
1 287 ILE n 
1 288 GLY n 
1 289 GLU n 
1 290 PHE n 
1 291 LEU n 
1 292 ARG n 
1 293 GLN n 
1 294 HIS n 
1 295 TRP n 
1 296 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   296 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'uncultured bacterium' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     77133 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          pET22 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    7ATD 
_struct_ref.pdbx_db_accession          7ATD 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 7ATD A 1 ? 296 ? 7ATD 1 ? 296 ? 1 296 
2 1 7ATD B 1 ? 296 ? 7ATD 1 ? 296 ? 1 296 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer         . 'ACETATE ION'           ? 'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking' y ALANINE                 ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE              ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'         ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                ? 'C3 H7 N O2 S'   121.158 
FMT non-polymer         . 'FORMIC ACID'           ? 'C H2 O2'        46.025  
GLN 'L-peptide linking' y GLUTAMINE               ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'         ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                 ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE               ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                   ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE              ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                 ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                  ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE              ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE           ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                 ? 'C5 H9 N O2'     115.130 
RXH non-polymer         n 'Naproxen Methyl Ester' 
;Methyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate; (S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate; (S)-Naproxen Methyl Ester; methyl-naproxen;
;
'C15 H16 O3'     244.286 
SER 'L-peptide linking' y SERINE                  ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE               ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN              ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                  ? 'C5 H11 N O2'    117.146 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   7ATD 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                      ? 
_exptl_crystal.density_diffrn              ? 
_exptl_crystal.density_Matthews            2.17 
_exptl_crystal.density_method              ? 
_exptl_crystal.density_percent_sol         43.19 
_exptl_crystal.description                 ? 
_exptl_crystal.F_000                       ? 
_exptl_crystal.id                          1 
_exptl_crystal.preparation                 ? 
_exptl_crystal.size_max                    ? 
_exptl_crystal.size_mid                    ? 
_exptl_crystal.size_min                    ? 
_exptl_crystal.size_rad                    ? 
_exptl_crystal.colour_lustre               ? 
_exptl_crystal.colour_modifier             ? 
_exptl_crystal.colour_primary              ? 
_exptl_crystal.density_meas                ? 
_exptl_crystal.density_meas_esd            ? 
_exptl_crystal.density_meas_gt             ? 
_exptl_crystal.density_meas_lt             ? 
_exptl_crystal.density_meas_temp           ? 
_exptl_crystal.density_meas_temp_esd       ? 
_exptl_crystal.density_meas_temp_gt        ? 
_exptl_crystal.density_meas_temp_lt        ? 
_exptl_crystal.pdbx_crystal_image_url      ? 
_exptl_crystal.pdbx_crystal_image_format   ? 
_exptl_crystal.pdbx_mosaicity              ? 
_exptl_crystal.pdbx_mosaicity_esd          ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp            291 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '3.2M Sodium formate + 0.1M citrate pH 5' 
_exptl_crystal_grow.pdbx_pH_range   5 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     291 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2017-03-11 
_diffrn_detector.pdbx_frequency               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.072 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALBA BEAMLINE XALOC' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.072 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   XALOC 
_diffrn_source.pdbx_synchrotron_site       ALBA 
# 
_reflns.B_iso_Wilson_estimate            ? 
_reflns.entry_id                         7ATD 
_reflns.data_reduction_details           ? 
_reflns.data_reduction_method            ? 
_reflns.d_resolution_high                1.45 
_reflns.d_resolution_low                 48.38 
_reflns.details                          ? 
_reflns.limit_h_max                      ? 
_reflns.limit_h_min                      ? 
_reflns.limit_k_max                      ? 
_reflns.limit_k_min                      ? 
_reflns.limit_l_max                      ? 
_reflns.limit_l_min                      ? 
_reflns.number_all                       ? 
_reflns.number_obs                       99895 
_reflns.observed_criterion               ? 
_reflns.observed_criterion_F_max         ? 
_reflns.observed_criterion_F_min         ? 
_reflns.observed_criterion_I_max         ? 
_reflns.observed_criterion_I_min         ? 
_reflns.observed_criterion_sigma_F       ? 
_reflns.observed_criterion_sigma_I       ? 
_reflns.percent_possible_obs             100 
_reflns.R_free_details                   ? 
_reflns.Rmerge_F_all                     ? 
_reflns.Rmerge_F_obs                     ? 
_reflns.Friedel_coverage                 ? 
_reflns.number_gt                        ? 
_reflns.threshold_expression             ? 
_reflns.pdbx_redundancy                  10.2 
_reflns.pdbx_Rmerge_I_obs                0.142 
_reflns.pdbx_Rmerge_I_all                ? 
_reflns.pdbx_Rsym_value                  ? 
_reflns.pdbx_netI_over_av_sigmaI         ? 
_reflns.pdbx_netI_over_sigmaI            8.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2   ? 
_reflns.pdbx_res_netI_over_sigmaI_2      ? 
_reflns.pdbx_chi_squared                 ? 
_reflns.pdbx_scaling_rejects             ? 
_reflns.pdbx_d_res_high_opt              ? 
_reflns.pdbx_d_res_low_opt               ? 
_reflns.pdbx_d_res_opt_method            ? 
_reflns.phase_calculation_details        ? 
_reflns.pdbx_Rrim_I_all                  ? 
_reflns.pdbx_Rpim_I_all                  0.047 
_reflns.pdbx_d_opt                       ? 
_reflns.pdbx_number_measured_all         ? 
_reflns.pdbx_diffrn_id                   1 
_reflns.pdbx_ordinal                     1 
_reflns.pdbx_CC_half                     0.997 
_reflns.pdbx_CC_star                     ? 
_reflns.pdbx_R_split                     ? 
# 
_reflns_shell.d_res_high                  1.45 
_reflns_shell.d_res_low                   1.47 
_reflns_shell.meanI_over_sigI_all         ? 
_reflns_shell.meanI_over_sigI_obs         1.2 
_reflns_shell.number_measured_all         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_possible             ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.number_unique_obs           4827 
_reflns_shell.percent_possible_all        100 
_reflns_shell.percent_possible_obs        ? 
_reflns_shell.Rmerge_F_all                ? 
_reflns_shell.Rmerge_F_obs                ? 
_reflns_shell.Rmerge_I_all                ? 
_reflns_shell.Rmerge_I_obs                1.752 
_reflns_shell.meanI_over_sigI_gt          ? 
_reflns_shell.meanI_over_uI_all           ? 
_reflns_shell.meanI_over_uI_gt            ? 
_reflns_shell.number_measured_gt          ? 
_reflns_shell.number_unique_gt            ? 
_reflns_shell.percent_possible_gt         ? 
_reflns_shell.Rmerge_F_gt                 ? 
_reflns_shell.Rmerge_I_gt                 ? 
_reflns_shell.pdbx_redundancy             10.3 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.pdbx_chi_squared            ? 
_reflns_shell.pdbx_netI_over_sigmaI_all   ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs   ? 
_reflns_shell.pdbx_Rrim_I_all             ? 
_reflns_shell.pdbx_Rpim_I_all             0.570 
_reflns_shell.pdbx_rejects                ? 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_CC_half                0.530 
_reflns_shell.pdbx_CC_star                ? 
_reflns_shell.pdbx_R_split                ? 
# 
_refine.aniso_B[1][1]                            0.0100 
_refine.aniso_B[1][2]                            0.0000 
_refine.aniso_B[1][3]                            -0.0000 
_refine.aniso_B[2][2]                            -0.0000 
_refine.aniso_B[2][3]                            0.0000 
_refine.aniso_B[3][3]                            -0.0000 
_refine.B_iso_max                                84.720 
_refine.B_iso_mean                               18.9710 
_refine.B_iso_min                                9.020 
_refine.correlation_coeff_Fo_to_Fc               0.9740 
_refine.correlation_coeff_Fo_to_Fc_free          0.9660 
_refine.details                                  
'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES      : REFINED INDIVIDUALLY' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 7ATD 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.4500 
_refine.ls_d_res_low                             45.4800 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     94720 
_refine.ls_number_reflns_R_free                  5071 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.9700 
_refine.ls_percent_reflns_R_free                 5.1000 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1680 
_refine.ls_R_factor_R_free                       0.1915 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1668 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.000 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      7AT0 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.0670 
_refine.pdbx_overall_ESU_R_Free                  0.0680 
_refine.pdbx_solvent_vdw_probe_radii             1.2000 
_refine.pdbx_solvent_ion_probe_radii             0.8000 
_refine.pdbx_solvent_shrinkage_radii             0.8000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             1.5000 
_refine.overall_SU_ML                            0.0540 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         final 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.4500 
_refine_hist.d_res_low                        45.4800 
_refine_hist.number_atoms_solvent             673 
_refine_hist.number_atoms_total               5235 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       590 
_refine_hist.pdbx_B_iso_mean_ligand           36.84 
_refine_hist.pdbx_B_iso_mean_solvent          36.03 
_refine_hist.pdbx_number_atoms_protein        4494 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         68 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.013  4878  ? r_bond_refined_d       ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.017  4700  ? r_bond_other_d         ? ? 
'X-RAY DIFFRACTION' ? 1.526  1.651  6670  ? r_angle_refined_deg    ? ? 
'X-RAY DIFFRACTION' ? 1.452  1.577  10795 ? r_angle_other_deg      ? ? 
'X-RAY DIFFRACTION' ? 5.951  5.000  638   ? r_dihedral_angle_1_deg ? ? 
'X-RAY DIFFRACTION' ? 28.024 20.236 254   ? r_dihedral_angle_2_deg ? ? 
'X-RAY DIFFRACTION' ? 13.549 15.000 781   ? r_dihedral_angle_3_deg ? ? 
'X-RAY DIFFRACTION' ? 20.228 15.000 52    ? r_dihedral_angle_4_deg ? ? 
'X-RAY DIFFRACTION' ? 0.082  0.200  628   ? r_chiral_restr         ? ? 
'X-RAY DIFFRACTION' ? 0.008  0.020  5677  ? r_gen_planes_refined   ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.020  1101  ? r_gen_planes_other     ? ? 
# 
loop_
_refine_ls_restr_ncs.pdbx_refine_id 
_refine_ls_restr_ncs.dom_id 
_refine_ls_restr_ncs.ncs_model_details 
_refine_ls_restr_ncs.rms_dev_B_iso 
_refine_ls_restr_ncs.rms_dev_position 
_refine_ls_restr_ncs.weight_B_iso 
_refine_ls_restr_ncs.weight_position 
_refine_ls_restr_ncs.pdbx_ordinal 
_refine_ls_restr_ncs.pdbx_type 
_refine_ls_restr_ncs.pdbx_asym_id 
_refine_ls_restr_ncs.pdbx_auth_asym_id 
_refine_ls_restr_ncs.pdbx_number 
_refine_ls_restr_ncs.pdbx_rms 
_refine_ls_restr_ncs.pdbx_weight 
_refine_ls_restr_ncs.pdbx_ens_id 
'X-RAY DIFFRACTION' 1 ? ? 0.100 ? 0.050 1 'interatomic distance' ? A 9638 ? ? 1 
'X-RAY DIFFRACTION' 2 ? ? 0.100 ? 0.050 2 'interatomic distance' ? B 9638 ? ? 1 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.4500 
_refine_ls_shell.d_res_low                        1.4880 
_refine_ls_shell.number_reflns_all                7269 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             340 
_refine_ls_shell.number_reflns_R_work             6929 
_refine_ls_shell.percent_reflns_obs               100.0000 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free                  0.3160 
_refine_ls_shell.R_factor_R_free_error            0.0000 
_refine_ls_shell.R_factor_R_work                  0.3250 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
# 
loop_
_struct_ncs_dom.pdbx_ens_id 
_struct_ncs_dom.id 
_struct_ncs_dom.details 
1 1 A 
1 2 B 
# 
loop_
_struct_ncs_dom_lim.pdbx_ens_id 
_struct_ncs_dom_lim.dom_id 
_struct_ncs_dom_lim.pdbx_component_id 
_struct_ncs_dom_lim.pdbx_refine_code 
_struct_ncs_dom_lim.beg_auth_asym_id 
_struct_ncs_dom_lim.beg_auth_seq_id 
_struct_ncs_dom_lim.end_auth_asym_id 
_struct_ncs_dom_lim.end_auth_seq_id 
_struct_ncs_dom_lim.selection_details 
_struct_ncs_dom_lim.beg_label_asym_id 
_struct_ncs_dom_lim.beg_label_comp_id 
_struct_ncs_dom_lim.beg_label_seq_id 
_struct_ncs_dom_lim.beg_label_alt_id 
_struct_ncs_dom_lim.end_label_asym_id 
_struct_ncs_dom_lim.end_label_comp_id 
_struct_ncs_dom_lim.end_label_seq_id 
_struct_ncs_dom_lim.end_label_alt_id 
1 1 0 0 A 2 A 296 ? ? ? ? ? ? ? ? ? 
1 2 0 0 B 2 B 296 ? ? ? ? ? ? ? ? ? 
# 
_struct_ncs_ens.id        1 
_struct_ncs_ens.details   ? 
# 
_struct.entry_id                     7ATD 
_struct.title                        'Structure of inactive EstD11 S144A in complex with methyl-naproxen' 
_struct.pdbx_descriptor              'EstD11 S144A' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        7ATD 
_struct_keywords.text            'Esterase Hormone-Sensitive Lipase Metagenome library Crystal structure, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
I N N 3 ? 
J N N 2 ? 
K N N 2 ? 
L N N 2 ? 
M N N 2 ? 
N N N 2 ? 
O N N 2 ? 
P N N 2 ? 
Q N N 4 ? 
R N N 2 ? 
S N N 3 ? 
T N N 5 ? 
U N N 5 ? 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 4   ? ARG A 17  ? GLU A 4   ARG A 17  1 ? 14 
HELX_P HELX_P2  AA2 PRO A 18  ? GLU A 21  ? PRO A 18  GLU A 21  5 ? 4  
HELX_P HELX_P3  AA3 THR A 23  ? GLN A 36  ? THR A 23  GLN A 36  1 ? 14 
HELX_P HELX_P4  AA4 SER A 82  ? ARG A 98  ? SER A 82  ARG A 98  1 ? 17 
HELX_P HELX_P5  AA5 PRO A 115 ? THR A 131 ? PRO A 115 THR A 131 1 ? 17 
HELX_P HELX_P6  AA6 ASP A 134 ? LYS A 136 ? ASP A 134 LYS A 136 5 ? 3  
HELX_P HELX_P7  AA7 ALA A 144 ? ALA A 160 ? ALA A 144 ALA A 160 1 ? 17 
HELX_P HELX_P8  AA8 GLY A 181 ? LYS A 187 ? GLY A 181 LYS A 187 1 ? 7  
HELX_P HELX_P9  AA9 GLN A 195 ? ALA A 208 ? GLN A 195 ALA A 208 1 ? 14 
HELX_P HELX_P10 AB1 ALA A 218 ? ALA A 222 ? ALA A 218 ALA A 222 5 ? 5  
HELX_P HELX_P11 AB2 LEU A 240 ? ALA A 254 ? LEU A 240 ALA A 254 1 ? 15 
HELX_P HELX_P12 AB3 VAL A 269 ? ALA A 274 ? VAL A 269 ALA A 274 5 ? 6  
HELX_P HELX_P13 AB4 LEU A 277 ? GLN A 296 ? LEU A 277 GLN A 296 1 ? 20 
HELX_P HELX_P14 AB5 SER B 3   ? ARG B 17  ? SER B 3   ARG B 17  1 ? 15 
HELX_P HELX_P15 AB6 PRO B 18  ? GLU B 21  ? PRO B 18  GLU B 21  5 ? 4  
HELX_P HELX_P16 AB7 THR B 23  ? GLN B 36  ? THR B 23  GLN B 36  1 ? 14 
HELX_P HELX_P17 AB8 SER B 82  ? ARG B 98  ? SER B 82  ARG B 98  1 ? 17 
HELX_P HELX_P18 AB9 PRO B 115 ? THR B 131 ? PRO B 115 THR B 131 1 ? 17 
HELX_P HELX_P19 AC1 ASP B 134 ? LYS B 136 ? ASP B 134 LYS B 136 5 ? 3  
HELX_P HELX_P20 AC2 ALA B 144 ? ALA B 160 ? ALA B 144 ALA B 160 1 ? 17 
HELX_P HELX_P21 AC3 GLU B 182 ? LYS B 187 ? GLU B 182 LYS B 187 1 ? 6  
HELX_P HELX_P22 AC4 GLN B 195 ? ALA B 208 ? GLN B 195 ALA B 208 1 ? 14 
HELX_P HELX_P23 AC5 ALA B 218 ? ALA B 222 ? ALA B 218 ALA B 222 5 ? 5  
HELX_P HELX_P24 AC6 LEU B 240 ? ALA B 254 ? LEU B 240 ALA B 254 1 ? 15 
HELX_P HELX_P25 AC7 VAL B 269 ? ALA B 274 ? VAL B 269 ALA B 274 5 ? 6  
HELX_P HELX_P26 AC8 LEU B 277 ? TRP B 295 ? LEU B 277 TRP B 295 1 ? 19 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ALA 109 A . ? ALA 109 A PRO 110 A ? PRO 110 A 1 -2.54 
2 HIS 114 A . ? HIS 114 A PRO 115 A ? PRO 115 A 1 6.65  
3 ALA 109 B . ? ALA 109 B PRO 110 B ? PRO 110 B 1 1.82  
4 HIS 114 B . ? HIS 114 B PRO 115 B ? PRO 115 B 1 8.99  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? parallel      
AA1 7 8 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA2 6 7 ? parallel      
AA2 7 8 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 45  ? ASP A 50  ? GLU A 45  ASP A 50  
AA1 2 PRO A 55  ? ARG A 60  ? PRO A 55  ARG A 60  
AA1 3 CYS A 99  ? ILE A 104 ? CYS A 99  ILE A 104 
AA1 4 ASP A 65  ? LEU A 73  ? ASP A 65  LEU A 73  
AA1 5 MET A 138 ? ASP A 143 ? MET A 138 ASP A 143 
AA1 6 ALA A 167 ? LEU A 171 ? ALA A 167 LEU A 171 
AA1 7 LEU A 230 ? GLY A 235 ? LEU A 230 GLY A 235 
AA1 8 VAL A 258 ? TRP A 263 ? VAL A 258 TRP A 263 
AA2 1 GLU B 45  ? ALA B 51  ? GLU B 45  ALA B 51  
AA2 2 VAL B 54  ? ARG B 60  ? VAL B 54  ARG B 60  
AA2 3 CYS B 99  ? ILE B 104 ? CYS B 99  ILE B 104 
AA2 4 ASP B 65  ? LEU B 73  ? ASP B 65  LEU B 73  
AA2 5 MET B 138 ? ASP B 143 ? MET B 138 ASP B 143 
AA2 6 ALA B 167 ? LEU B 171 ? ALA B 167 LEU B 171 
AA2 7 LEU B 230 ? GLY B 235 ? LEU B 230 GLY B 235 
AA2 8 VAL B 258 ? TRP B 263 ? VAL B 258 TRP B 263 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N THR A 47  ? N THR A 47  O TRP A 58  ? O TRP A 58  
AA1 2 3 N ALA A 57  ? N ALA A 57  O LEU A 103 ? O LEU A 103 
AA1 3 4 O LEU A 102 ? O LEU A 102 N VAL A 70  ? N VAL A 70  
AA1 4 5 N LEU A 73  ? N LEU A 73  O ALA A 141 ? O ALA A 141 
AA1 5 6 N GLY A 142 ? N GLY A 142 O LEU A 171 ? O LEU A 171 
AA1 6 7 N CYS A 170 ? N CYS A 170 O LEU A 231 ? O LEU A 231 
AA1 7 8 N ILE A 232 ? N ILE A 232 O GLU A 261 ? O GLU A 261 
AA2 1 2 N ALA B 51  ? N ALA B 51  O VAL B 54  ? O VAL B 54  
AA2 2 3 N ALA B 57  ? N ALA B 57  O LEU B 103 ? O LEU B 103 
AA2 3 4 O LEU B 102 ? O LEU B 102 N TYR B 72  ? N TYR B 72  
AA2 4 5 N LEU B 73  ? N LEU B 73  O ALA B 141 ? O ALA B 141 
AA2 5 6 N GLY B 142 ? N GLY B 142 O LEU B 171 ? O LEU B 171 
AA2 6 7 N CYS B 170 ? N CYS B 170 O LEU B 231 ? O LEU B 231 
AA2 7 8 N ILE B 232 ? N ILE B 232 O GLU B 261 ? O GLU B 261 
# 
loop_
_struct_site.id 
_struct_site.pdbx_evidence_code 
_struct_site.pdbx_auth_asym_id 
_struct_site.pdbx_auth_comp_id 
_struct_site.pdbx_auth_seq_id 
_struct_site.pdbx_auth_ins_code 
_struct_site.pdbx_num_residues 
_struct_site.details 
AC1 Software A FMT 1301 ? 5  'binding site for residue FMT A 1301' 
AC2 Software A FMT 1302 ? 5  'binding site for residue FMT A 1302' 
AC3 Software A FMT 1303 ? 4  'binding site for residue FMT A 1303' 
AC4 Software A FMT 1304 ? 7  'binding site for residue FMT A 1304' 
AC5 Software A FMT 1305 ? 4  'binding site for residue FMT A 1305' 
AC6 Software A FMT 1306 ? 8  'binding site for residue FMT A 1306' 
AC7 Software A ACT 1307 ? 5  'binding site for residue ACT A 1307' 
AC8 Software A FMT 1308 ? 4  'binding site for residue FMT A 1308' 
AC9 Software A FMT 1309 ? 7  'binding site for residue FMT A 1309' 
AD1 Software A FMT 1310 ? 7  'binding site for residue FMT A 1310' 
AD2 Software A FMT 1311 ? 2  'binding site for residue FMT A 1311' 
AD3 Software A FMT 1312 ? 3  'binding site for residue FMT A 1312' 
AD4 Software A FMT 1313 ? 7  'binding site for residue FMT A 1313' 
AD5 Software A FMT 1314 ? 5  'binding site for residue FMT A 1314' 
AD6 Software B RXH 1301 ? 11 'binding site for residue RXH B 1301' 
AD7 Software B FMT 1302 ? 3  'binding site for residue FMT B 1302' 
AD8 Software B ACT 1303 ? 6  'binding site for residue ACT B 1303' 
# 
loop_
_struct_site_gen.id 
_struct_site_gen.site_id 
_struct_site_gen.pdbx_num_res 
_struct_site_gen.label_comp_id 
_struct_site_gen.label_asym_id 
_struct_site_gen.label_seq_id 
_struct_site_gen.pdbx_auth_ins_code 
_struct_site_gen.auth_comp_id 
_struct_site_gen.auth_asym_id 
_struct_site_gen.auth_seq_id 
_struct_site_gen.label_atom_id 
_struct_site_gen.label_alt_id 
_struct_site_gen.symmetry 
_struct_site_gen.details 
1  AC1 5  VAL A 49  ? VAL A 49   . ? 1_555 ? 
2  AC1 5  TRP A 58  ? TRP A 58   . ? 1_555 ? 
3  AC1 5  TRP A 127 ? TRP A 127  . ? 1_555 ? 
4  AC1 5  HOH T .   ? HOH A 1563 . ? 1_555 ? 
5  AC1 5  HOH T .   ? HOH A 1642 . ? 1_555 ? 
6  AC2 5  GLU A 45  ? GLU A 45   . ? 1_555 ? 
7  AC2 5  LEU A 46  ? LEU A 46   . ? 1_555 ? 
8  AC2 5  THR A 47  ? THR A 47   . ? 1_555 ? 
9  AC2 5  FMT E .   ? FMT A 1303 . ? 1_555 ? 
10 AC2 5  HOH T .   ? HOH A 1493 . ? 1_555 ? 
11 AC3 4  LEU A 46  ? LEU A 46   . ? 1_555 ? 
12 AC3 4  THR A 47  ? THR A 47   . ? 1_555 ? 
13 AC3 4  THR A 48  ? THR A 48   . ? 1_555 ? 
14 AC3 4  FMT D .   ? FMT A 1302 . ? 1_555 ? 
15 AC4 7  GLU A 4   ? GLU A 4    . ? 1_655 ? 
16 AC4 7  ARG A 107 ? ARG A 107  . ? 1_555 ? 
17 AC4 7  GLU A 111 ? GLU A 111  . ? 1_555 ? 
18 AC4 7  HIS A 112 ? HIS A 112  . ? 1_555 ? 
19 AC4 7  HOH T .   ? HOH A 1404 . ? 1_555 ? 
20 AC4 7  HOH T .   ? HOH A 1503 . ? 1_555 ? 
21 AC4 7  HOH T .   ? HOH A 1573 . ? 1_555 ? 
22 AC5 4  ARG A 68  ? ARG A 68   . ? 1_555 ? 
23 AC5 4  ARG A 292 ? ARG A 292  . ? 1_555 ? 
24 AC5 4  GLN A 296 ? GLN A 296  . ? 1_555 ? 
25 AC5 4  THR B 131 ? THR B 131  . ? 4_455 ? 
26 AC6 8  PRO A 22  ? PRO A 22   . ? 1_555 ? 
27 AC6 8  ARG A 201 ? ARG A 201  . ? 1_555 ? 
28 AC6 8  MET A 205 ? MET A 205  . ? 1_555 ? 
29 AC6 8  HOH T .   ? HOH A 1402 . ? 1_555 ? 
30 AC6 8  HOH T .   ? HOH A 1433 . ? 1_555 ? 
31 AC6 8  HOH T .   ? HOH A 1581 . ? 1_555 ? 
32 AC6 8  VAL B 258 ? VAL B 258  . ? 3_644 ? 
33 AC6 8  THR B 259 ? THR B 259  . ? 3_644 ? 
34 AC7 5  GLY A 76  ? GLY A 76   . ? 1_555 ? 
35 AC7 5  GLY A 77  ? GLY A 77   . ? 1_555 ? 
36 AC7 5  ALA A 144 ? ALA A 144  . ? 1_555 ? 
37 AC7 5  ALA A 145 ? ALA A 145  . ? 1_555 ? 
38 AC7 5  HIS A 268 ? HIS A 268  . ? 1_555 ? 
39 AC8 4  THR A 47  ? THR A 47   . ? 1_555 ? 
40 AC8 4  TRP A 58  ? TRP A 58   . ? 1_555 ? 
41 AC8 4  ARG A 60  ? ARG A 60   . ? 1_555 ? 
42 AC8 4  ARG A 100 ? ARG A 100  . ? 1_555 ? 
43 AC9 7  ARG A 68  ? ARG A 68   . ? 1_555 ? 
44 AC9 7  TRP A 295 ? TRP A 295  . ? 1_555 ? 
45 AC9 7  GLN A 296 ? GLN A 296  . ? 1_555 ? 
46 AC9 7  HOH T .   ? HOH A 1495 . ? 1_555 ? 
47 AC9 7  HOH T .   ? HOH A 1514 . ? 1_555 ? 
48 AC9 7  THR B 131 ? THR B 131  . ? 4_455 ? 
49 AC9 7  GLY B 132 ? GLY B 132  . ? 4_455 ? 
50 AD1 7  TYR A 221 ? TYR A 221  . ? 4_445 ? 
51 AD1 7  ASP A 223 ? ASP A 223  . ? 4_445 ? 
52 AD1 7  ARG A 250 ? ARG A 250  . ? 4_445 ? 
53 AD1 7  ARG A 286 ? ARG A 286  . ? 1_555 ? 
54 AD1 7  HOH T .   ? HOH A 1415 . ? 1_555 ? 
55 AD1 7  HOH T .   ? HOH A 1421 . ? 1_555 ? 
56 AD1 7  HOH T .   ? HOH A 1640 . ? 1_555 ? 
57 AD2 2  HOH T .   ? HOH A 1504 . ? 1_555 ? 
58 AD2 2  HOH T .   ? HOH A 1525 . ? 1_555 ? 
59 AD3 3  ARG A 87  ? ARG A 87   . ? 1_555 ? 
60 AD3 3  HOH T .   ? HOH A 1432 . ? 1_555 ? 
61 AD3 3  HOH T .   ? HOH A 1455 . ? 1_555 ? 
62 AD4 7  GLY A 226 ? GLY A 226  . ? 1_555 ? 
63 AD4 7  PRO A 262 ? PRO A 262  . ? 4_545 ? 
64 AD4 7  TRP A 263 ? TRP A 263  . ? 4_545 ? 
65 AD4 7  GLU A 264 ? GLU A 264  . ? 4_545 ? 
66 AD4 7  HOH T .   ? HOH A 1469 . ? 1_555 ? 
67 AD4 7  HOH T .   ? HOH A 1520 . ? 1_555 ? 
68 AD4 7  HOH T .   ? HOH A 1644 . ? 1_555 ? 
69 AD5 5  GLY B 181 ? GLY B 181  . ? 3_644 ? 
70 AD5 5  GLU B 182 ? GLU B 182  . ? 3_644 ? 
71 AD5 5  ASP B 242 ? ASP B 242  . ? 3_644 ? 
72 AD5 5  ARG B 246 ? ARG B 246  . ? 3_644 ? 
73 AD5 5  HOH U .   ? HOH B 1602 . ? 3_644 ? 
74 AD6 11 LEU B 19  ? LEU B 19   . ? 1_555 ? 
75 AD6 11 MET B 34  ? MET B 34   . ? 1_555 ? 
76 AD6 11 ALA B 35  ? ALA B 35   . ? 1_555 ? 
77 AD6 11 GLY B 75  ? GLY B 75   . ? 1_555 ? 
78 AD6 11 GLY B 76  ? GLY B 76   . ? 1_555 ? 
79 AD6 11 THR B 85  ? THR B 85   . ? 1_555 ? 
80 AD6 11 ASP B 143 ? ASP B 143  . ? 1_555 ? 
81 AD6 11 MET B 193 ? MET B 193  . ? 1_555 ? 
82 AD6 11 HIS B 268 ? HIS B 268  . ? 1_555 ? 
83 AD6 11 ALA B 272 ? ALA B 272  . ? 1_555 ? 
84 AD6 11 ACT S .   ? ACT B 1303 . ? 1_555 ? 
85 AD7 3  GLN B 16  ? GLN B 16   . ? 1_555 ? 
86 AD7 3  MET B 34  ? MET B 34   . ? 1_555 ? 
87 AD7 3  PHE B 273 ? PHE B 273  . ? 1_555 ? 
88 AD8 6  GLY B 76  ? GLY B 76   . ? 1_555 ? 
89 AD8 6  GLY B 77  ? GLY B 77   . ? 1_555 ? 
90 AD8 6  ALA B 144 ? ALA B 144  . ? 1_555 ? 
91 AD8 6  ALA B 145 ? ALA B 145  . ? 1_555 ? 
92 AD8 6  HIS B 268 ? HIS B 268  . ? 1_555 ? 
93 AD8 6  RXH Q .   ? RXH B 1301 . ? 1_555 ? 
# 
_atom_sites.entry_id                    7ATD 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   0.020900 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012462 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006890 
_atom_sites.fract_transf_vector[1]      0.000000 
_atom_sites.fract_transf_vector[2]      0.000000 
_atom_sites.fract_transf_vector[3]      0.000000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 2.310  20.844 1.020 10.208 1.589 0.569  0.865 51.651 0.216   
H 0.493  10.511 0.323 26.126 0.140 3.142  0.041 57.800 0.003   
N 12.222 0.006  3.135 9.893  2.014 28.997 1.167 0.583  -11.538 
O 3.049  13.277 2.287 5.701  1.546 0.324  0.867 32.909 0.251   
S 6.905  1.468  5.203 22.215 1.438 0.254  1.586 56.172 1.056   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . ALA A 1 2   ? -18.343 -11.946 -13.915 1.00 33.41 ? 2    ALA A N   1 ? 
ATOM   2    C CA  . ALA A 1 2   ? -17.415 -10.819 -13.679 1.00 31.59 ? 2    ALA A CA  1 ? 
ATOM   3    C C   . ALA A 1 2   ? -18.107 -9.502  -14.048 1.00 29.83 ? 2    ALA A C   1 ? 
ATOM   4    O O   . ALA A 1 2   ? -19.179 -9.534  -14.671 1.00 32.06 ? 2    ALA A O   1 ? 
ATOM   5    C CB  . ALA A 1 2   ? -16.140 -11.047 -14.468 1.00 31.19 ? 2    ALA A CB  1 ? 
ATOM   6    N N   . SER A 1 3   ? -17.547 -8.374  -13.634 1.00 27.19 ? 3    SER A N   1 ? 
ATOM   7    C CA  . SER A 1 3   ? -18.044 -7.018  -13.962 1.00 26.02 ? 3    SER A CA  1 ? 
ATOM   8    C C   . SER A 1 3   ? -18.140 -6.892  -15.484 1.00 28.06 ? 3    SER A C   1 ? 
ATOM   9    O O   . SER A 1 3   ? -17.431 -7.638  -16.210 1.00 25.59 ? 3    SER A O   1 ? 
ATOM   10   C CB  . SER A 1 3   ? -17.169 -5.958  -13.400 1.00 26.29 ? 3    SER A CB  1 ? 
ATOM   11   O OG  . SER A 1 3   ? -15.870 -6.069  -13.964 1.00 25.54 ? 3    SER A OG  1 ? 
ATOM   12   N N   . GLU A 1 4   ? -18.987 -5.977  -15.951 1.00 30.73 ? 4    GLU A N   1 ? 
ATOM   13   C CA  . GLU A 1 4   ? -19.069 -5.599  -17.386 1.00 31.13 ? 4    GLU A CA  1 ? 
ATOM   14   C C   . GLU A 1 4   ? -17.706 -5.147  -17.893 1.00 29.35 ? 4    GLU A C   1 ? 
ATOM   15   O O   . GLU A 1 4   ? -17.378 -5.400  -19.080 1.00 29.73 ? 4    GLU A O   1 ? 
ATOM   16   C CB  . GLU A 1 4   ? -19.997 -4.406  -17.569 1.00 33.56 ? 4    GLU A CB  1 ? 
ATOM   17   C CG  . GLU A 1 4   ? -21.443 -4.761  -17.408 1.00 35.61 ? 4    GLU A CG  1 ? 
ATOM   18   C CD  . GLU A 1 4   ? -22.330 -3.550  -17.594 1.00 35.93 ? 4    GLU A CD  1 ? 
ATOM   19   O OE1 . GLU A 1 4   ? -23.107 -3.246  -16.672 1.00 36.00 ? 4    GLU A OE1 1 ? 
ATOM   20   O OE2 . GLU A 1 4   ? -22.195 -2.897  -18.649 1.00 35.84 ? 4    GLU A OE2 1 ? 
ATOM   21   N N   . ALA A 1 5   ? -16.983 -4.431  -17.035 1.00 26.10 ? 5    ALA A N   1 ? 
ATOM   22   C CA  . ALA A 1 5   ? -15.677 -3.841  -17.363 1.00 23.91 ? 5    ALA A CA  1 ? 
ATOM   23   C C   . ALA A 1 5   ? -14.741 -4.953  -17.852 1.00 23.00 ? 5    ALA A C   1 ? 
ATOM   24   O O   . ALA A 1 5   ? -13.872 -4.632  -18.668 1.00 21.37 ? 5    ALA A O   1 ? 
ATOM   25   C CB  . ALA A 1 5   ? -15.128 -3.069  -16.194 1.00 26.50 ? 5    ALA A CB  1 ? 
ATOM   26   N N   . LEU A 1 6   ? -14.886 -6.202  -17.415 1.00 20.76 ? 6    LEU A N   1 ? 
ATOM   27   C CA  . LEU A 1 6   ? -13.947 -7.268  -17.875 1.00 20.61 ? 6    LEU A CA  1 ? 
ATOM   28   C C   . LEU A 1 6   ? -14.005 -7.409  -19.404 1.00 20.37 ? 6    LEU A C   1 ? 
ATOM   29   O O   . LEU A 1 6   ? -12.946 -7.521  -20.040 1.00 17.37 ? 6    LEU A O   1 ? 
ATOM   30   C CB  . LEU A 1 6   ? -14.267 -8.611  -17.222 1.00 21.11 ? 6    LEU A CB  1 ? 
ATOM   31   C CG  . LEU A 1 6   ? -13.364 -9.762  -17.648 1.00 22.08 ? 6    LEU A CG  1 ? 
ATOM   32   C CD1 . LEU A 1 6   ? -11.913 -9.507  -17.233 1.00 22.03 ? 6    LEU A CD1 1 ? 
ATOM   33   C CD2 . LEU A 1 6   ? -13.849 -11.082 -17.068 1.00 23.65 ? 6    LEU A CD2 1 ? 
ATOM   34   N N   . THR A 1 7   ? -15.193 -7.412  -20.003 1.00 20.09 ? 7    THR A N   1 ? 
ATOM   35   C CA  . THR A 1 7   ? -15.328 -7.588  -21.475 1.00 21.03 ? 7    THR A CA  1 ? 
ATOM   36   C C   . THR A 1 7   ? -14.591 -6.453  -22.184 1.00 19.06 ? 7    THR A C   1 ? 
ATOM   37   O O   . THR A 1 7   ? -13.968 -6.699  -23.230 1.00 17.36 ? 7    THR A O   1 ? 
ATOM   38   C CB  . THR A 1 7   ? -16.796 -7.661  -21.919 1.00 22.35 ? 7    THR A CB  1 ? 
ATOM   39   O OG1 . THR A 1 7   ? -17.281 -8.923  -21.471 1.00 25.45 ? 7    THR A OG1 1 ? 
ATOM   40   C CG2 . THR A 1 7   ? -16.957 -7.570  -23.417 1.00 23.48 ? 7    THR A CG2 1 ? 
ATOM   41   N N   . MET A 1 8   ? -14.681 -5.248  -21.652 1.00 18.04 ? 8    MET A N   1 ? 
ATOM   42   C CA  . MET A 1 8   ? -14.026 -4.058  -22.242 1.00 18.58 ? 8    MET A CA  1 ? 
ATOM   43   C C   . MET A 1 8   ? -12.503 -4.234  -22.200 1.00 17.49 ? 8    MET A C   1 ? 
ATOM   44   O O   . MET A 1 8   ? -11.837 -3.937  -23.209 1.00 17.75 ? 8    MET A O   1 ? 
ATOM   45   C CB  . MET A 1 8   ? -14.434 -2.830  -21.447 1.00 21.60 ? 8    MET A CB  1 ? 
ATOM   46   C CG  . MET A 1 8   ? -13.698 -1.618  -21.858 1.00 23.88 ? 8    MET A CG  1 ? 
ATOM   47   S SD  . MET A 1 8   ? -14.312 -0.200  -20.969 1.00 28.69 ? 8    MET A SD  1 ? 
ATOM   48   C CE  . MET A 1 8   ? -13.700 -0.583  -19.328 1.00 31.37 ? 8    MET A CE  1 ? 
ATOM   49   N N   . ILE A 1 9   ? -11.980 -4.716  -21.076 1.00 16.68 ? 9    ILE A N   1 ? 
ATOM   50   C CA  . ILE A 1 9   ? -10.501 -4.908  -20.944 1.00 16.97 ? 9    ILE A CA  1 ? 
ATOM   51   C C   . ILE A 1 9   ? -10.065 -6.030  -21.889 1.00 17.25 ? 9    ILE A C   1 ? 
ATOM   52   O O   . ILE A 1 9   ? -8.999  -5.890  -22.563 1.00 16.36 ? 9    ILE A O   1 ? 
ATOM   53   C CB  . ILE A 1 9   ? -10.105 -5.177  -19.475 1.00 18.09 ? 9    ILE A CB  1 ? 
ATOM   54   C CG1 . ILE A 1 9   ? -10.478 -4.010  -18.557 1.00 19.70 ? 9    ILE A CG1 1 ? 
ATOM   55   C CG2 . ILE A 1 9   ? -8.621  -5.536  -19.398 1.00 18.27 ? 9    ILE A CG2 1 ? 
ATOM   56   C CD1 . ILE A 1 9   ? -9.983  -2.687  -19.002 1.00 20.70 ? 9    ILE A CD1 1 ? 
ATOM   57   N N   . VAL A 1 10  ? -10.815 -7.127  -21.955 1.00 15.78 ? 10   VAL A N   1 ? 
ATOM   58   C CA  . VAL A 1 10  ? -10.514 -8.244  -22.886 1.00 16.27 ? 10   VAL A CA  1 ? 
ATOM   59   C C   . VAL A 1 10  ? -10.489 -7.708  -24.325 1.00 17.00 ? 10   VAL A C   1 ? 
ATOM   60   O O   . VAL A 1 10  ? -9.574  -8.057  -25.081 1.00 15.28 ? 10   VAL A O   1 ? 
ATOM   61   C CB  . VAL A 1 10  ? -11.488 -9.417  -22.745 1.00 17.79 ? 10   VAL A CB  1 ? 
ATOM   62   C CG1 . VAL A 1 10  ? -11.272 -10.424 -23.863 1.00 18.02 ? 10   VAL A CG1 1 ? 
ATOM   63   C CG2 . VAL A 1 10  ? -11.348 -10.079 -21.386 1.00 19.06 ? 10   VAL A CG2 1 ? 
ATOM   64   N N   . ASN A 1 11  ? -11.485 -6.924  -24.717 1.00 16.16 ? 11   ASN A N   1 ? 
ATOM   65   C CA  . ASN A 1 11  ? -11.543 -6.383  -26.099 1.00 16.12 ? 11   ASN A CA  1 ? 
ATOM   66   C C   . ASN A 1 11  ? -10.316 -5.505  -26.364 1.00 15.51 ? 11   ASN A C   1 ? 
ATOM   67   O O   . ASN A 1 11  ? -9.779  -5.570  -27.476 1.00 17.45 ? 11   ASN A O   1 ? 
ATOM   68   C CB  . ASN A 1 11  ? -12.837 -5.616  -26.319 1.00 16.26 ? 11   ASN A CB  1 ? 
ATOM   69   C CG  . ASN A 1 11  ? -14.011 -6.548  -26.477 1.00 17.77 ? 11   ASN A CG  1 ? 
ATOM   70   O OD1 . ASN A 1 11  ? -13.863 -7.743  -26.752 1.00 20.78 ? 11   ASN A OD1 1 ? 
ATOM   71   N ND2 . ASN A 1 11  ? -15.208 -6.002  -26.342 1.00 16.83 ? 11   ASN A ND2 1 ? 
ATOM   72   N N   . LEU A 1 12  ? -9.922  -4.664  -25.416 1.00 16.35 ? 12   LEU A N   1 ? 
ATOM   73   C CA  . LEU A 1 12  ? -8.730  -3.793  -25.588 1.00 16.81 ? 12   LEU A CA  1 ? 
ATOM   74   C C   . LEU A 1 12  ? -7.495  -4.681  -25.818 1.00 17.39 ? 12   LEU A C   1 ? 
ATOM   75   O O   . LEU A 1 12  ? -6.724  -4.437  -26.772 1.00 16.82 ? 12   LEU A O   1 ? 
ATOM   76   C CB  . LEU A 1 12  ? -8.561  -2.927  -24.345 1.00 19.00 ? 12   LEU A CB  1 ? 
ATOM   77   C CG  . LEU A 1 12  ? -7.301  -2.079  -24.356 1.00 20.73 ? 12   LEU A CG  1 ? 
ATOM   78   C CD1 . LEU A 1 12  ? -7.451  -0.963  -25.360 1.00 23.09 ? 12   LEU A CD1 1 ? 
ATOM   79   C CD2 . LEU A 1 12  ? -6.992  -1.539  -22.982 1.00 22.40 ? 12   LEU A CD2 1 ? 
ATOM   80   N N   . LEU A 1 13  ? -7.323  -5.699  -24.987 1.00 17.26 ? 13   LEU A N   1 ? 
ATOM   81   C CA  . LEU A 1 13  ? -6.095  -6.536  -25.035 1.00 18.22 ? 13   LEU A CA  1 ? 
ATOM   82   C C   . LEU A 1 13  ? -6.064  -7.370  -26.314 1.00 18.44 ? 13   LEU A C   1 ? 
ATOM   83   O O   . LEU A 1 13  ? -4.970  -7.521  -26.905 1.00 19.30 ? 13   LEU A O   1 ? 
ATOM   84   C CB  . LEU A 1 13  ? -6.010  -7.393  -23.770 1.00 17.17 ? 13   LEU A CB  1 ? 
ATOM   85   C CG  . LEU A 1 13  ? -5.737  -6.584  -22.505 1.00 17.62 ? 13   LEU A CG  1 ? 
ATOM   86   C CD1 . LEU A 1 13  ? -5.864  -7.448  -21.272 1.00 18.04 ? 13   LEU A CD1 1 ? 
ATOM   87   C CD2 . LEU A 1 13  ? -4.350  -5.938  -22.516 1.00 19.29 ? 13   LEU A CD2 1 ? 
ATOM   88   N N   . ARG A 1 14  ? -7.201  -7.903  -26.757 1.00 18.03 ? 14   ARG A N   1 ? 
ATOM   89   C CA  . ARG A 1 14  ? -7.270  -8.722  -27.992 1.00 20.73 ? 14   ARG A CA  1 ? 
ATOM   90   C C   . ARG A 1 14  ? -6.848  -7.898  -29.208 1.00 21.10 ? 14   ARG A C   1 ? 
ATOM   91   O O   . ARG A 1 14  ? -6.315  -8.493  -30.181 1.00 21.58 ? 14   ARG A O   1 ? 
ATOM   92   C CB  . ARG A 1 14  ? -8.667  -9.312  -28.181 1.00 22.20 ? 14   ARG A CB  1 ? 
ATOM   93   C CG  . ARG A 1 14  ? -8.946  -10.439 -27.195 1.00 25.86 ? 14   ARG A CG  1 ? 
ATOM   94   C CD  . ARG A 1 14  ? -9.882  -11.507 -27.727 1.00 29.44 ? 14   ARG A CD  1 ? 
ATOM   95   N NE  . ARG A 1 14  ? -10.222 -12.449 -26.670 1.00 31.01 ? 14   ARG A NE  1 ? 
ATOM   96   C CZ  . ARG A 1 14  ? -9.535  -13.550 -26.357 1.00 33.11 ? 14   ARG A CZ  1 ? 
ATOM   97   N NH1 . ARG A 1 14  ? -8.449  -13.896 -27.034 1.00 31.53 ? 14   ARG A NH1 1 ? 
ATOM   98   N NH2 . ARG A 1 14  ? -9.963  -14.318 -25.368 1.00 31.88 ? 14   ARG A NH2 1 ? 
ATOM   99   N N   A SER A 1 15  ? -7.091  -6.585  -29.186 0.50 21.06 ? 15   SER A N   1 ? 
ATOM   100  N N   B SER A 1 15  ? -7.095  -6.588  -29.167 0.50 21.43 ? 15   SER A N   1 ? 
ATOM   101  C CA  A SER A 1 15  ? -6.730  -5.694  -30.319 0.50 22.39 ? 15   SER A CA  1 ? 
ATOM   102  C CA  B SER A 1 15  ? -6.767  -5.666  -30.279 0.50 23.00 ? 15   SER A CA  1 ? 
ATOM   103  C C   A SER A 1 15  ? -5.308  -5.174  -30.153 0.50 22.95 ? 15   SER A C   1 ? 
ATOM   104  C C   B SER A 1 15  ? -5.327  -5.168  -30.146 0.50 23.27 ? 15   SER A C   1 ? 
ATOM   105  O O   A SER A 1 15  ? -4.597  -5.137  -31.173 0.50 24.22 ? 15   SER A O   1 ? 
ATOM   106  O O   B SER A 1 15  ? -4.622  -5.142  -31.173 0.50 24.56 ? 15   SER A O   1 ? 
ATOM   107  C CB  A SER A 1 15  ? -7.688  -4.565  -30.499 0.50 23.85 ? 15   SER A CB  1 ? 
ATOM   108  C CB  B SER A 1 15  ? -7.731  -4.526  -30.350 0.50 25.06 ? 15   SER A CB  1 ? 
ATOM   109  O OG  A SER A 1 15  ? -8.901  -5.050  -31.035 0.50 24.49 ? 15   SER A OG  1 ? 
ATOM   110  O OG  B SER A 1 15  ? -7.685  -3.937  -31.634 0.50 26.14 ? 15   SER A OG  1 ? 
ATOM   111  N N   . GLN A 1 16  ? -4.911  -4.764  -28.946 1.00 21.57 ? 16   GLN A N   1 ? 
ATOM   112  C CA  . GLN A 1 16  ? -3.590  -4.124  -28.740 1.00 22.94 ? 16   GLN A CA  1 ? 
ATOM   113  C C   . GLN A 1 16  ? -2.512  -5.196  -28.825 1.00 25.73 ? 16   GLN A C   1 ? 
ATOM   114  O O   . GLN A 1 16  ? -1.479  -4.920  -29.467 1.00 24.98 ? 16   GLN A O   1 ? 
ATOM   115  C CB  . GLN A 1 16  ? -3.534  -3.321  -27.446 1.00 24.83 ? 16   GLN A CB  1 ? 
ATOM   116  C CG  . GLN A 1 16  ? -4.318  -2.015  -27.524 1.00 29.42 ? 16   GLN A CG  1 ? 
ATOM   117  C CD  . GLN A 1 16  ? -3.851  -1.120  -28.652 1.00 32.33 ? 16   GLN A CD  1 ? 
ATOM   118  O OE1 . GLN A 1 16  ? -2.689  -0.715  -28.702 1.00 35.03 ? 16   GLN A OE1 1 ? 
ATOM   119  N NE2 . GLN A 1 16  ? -4.763  -0.782  -29.557 1.00 33.43 ? 16   GLN A NE2 1 ? 
ATOM   120  N N   . ARG A 1 17  ? -2.723  -6.361  -28.213 1.00 27.04 ? 17   ARG A N   1 ? 
ATOM   121  C CA  . ARG A 1 17  ? -1.769  -7.501  -28.300 1.00 28.82 ? 17   ARG A CA  1 ? 
ATOM   122  C C   . ARG A 1 17  ? -0.380  -6.977  -27.964 1.00 28.55 ? 17   ARG A C   1 ? 
ATOM   123  O O   . ARG A 1 17  ? 0.553   -7.019  -28.771 1.00 26.42 ? 17   ARG A O   1 ? 
ATOM   124  C CB  . ARG A 1 17  ? -1.802  -8.111  -29.696 1.00 32.05 ? 17   ARG A CB  1 ? 
ATOM   125  C CG  . ARG A 1 17  ? -3.157  -8.676  -30.091 1.00 37.96 ? 17   ARG A CG  1 ? 
ATOM   126  C CD  . ARG A 1 17  ? -3.101  -9.360  -31.449 1.00 44.52 ? 17   ARG A CD  1 ? 
ATOM   127  N NE  . ARG A 1 17  ? -2.592  -10.726 -31.353 1.00 52.74 ? 17   ARG A NE  1 ? 
ATOM   128  C CZ  . ARG A 1 17  ? -1.700  -11.284 -32.175 1.00 54.83 ? 17   ARG A CZ  1 ? 
ATOM   129  N NH1 . ARG A 1 17  ? -1.164  -10.591 -33.167 1.00 56.16 ? 17   ARG A NH1 1 ? 
ATOM   130  N NH2 . ARG A 1 17  ? -1.316  -12.534 -31.972 1.00 56.55 ? 17   ARG A NH2 1 ? 
ATOM   131  N N   . PRO A 1 18  ? -0.189  -6.427  -26.756 1.00 28.78 ? 18   PRO A N   1 ? 
ATOM   132  C CA  . PRO A 1 18  ? 1.060   -5.733  -26.465 1.00 29.19 ? 18   PRO A CA  1 ? 
ATOM   133  C C   . PRO A 1 18  ? 2.307   -6.639  -26.514 1.00 30.45 ? 18   PRO A C   1 ? 
ATOM   134  O O   . PRO A 1 18  ? 3.366   -6.120  -26.772 1.00 28.34 ? 18   PRO A O   1 ? 
ATOM   135  C CB  . PRO A 1 18  ? 0.778   -5.145  -25.080 1.00 30.47 ? 18   PRO A CB  1 ? 
ATOM   136  C CG  . PRO A 1 18  ? -0.236  -6.080  -24.469 1.00 33.35 ? 18   PRO A CG  1 ? 
ATOM   137  C CD  . PRO A 1 18  ? -1.136  -6.441  -25.627 1.00 30.95 ? 18   PRO A CD  1 ? 
ATOM   138  N N   . LEU A 1 19  ? 2.173   -7.955  -26.299 1.00 25.87 ? 19   LEU A N   1 ? 
ATOM   139  C CA  . LEU A 1 19  ? 3.341   -8.888  -26.359 1.00 24.88 ? 19   LEU A CA  1 ? 
ATOM   140  C C   . LEU A 1 19  ? 3.603   -9.355  -27.803 1.00 27.52 ? 19   LEU A C   1 ? 
ATOM   141  O O   . LEU A 1 19  ? 4.572   -10.126 -28.008 1.00 28.49 ? 19   LEU A O   1 ? 
ATOM   142  C CB  . LEU A 1 19  ? 3.102   -10.063 -25.399 1.00 24.59 ? 19   LEU A CB  1 ? 
ATOM   143  C CG  . LEU A 1 19  ? 2.955   -9.684  -23.927 1.00 25.97 ? 19   LEU A CG  1 ? 
ATOM   144  C CD1 . LEU A 1 19  ? 2.760   -10.926 -23.057 1.00 25.92 ? 19   LEU A CD1 1 ? 
ATOM   145  C CD2 . LEU A 1 19  ? 4.147   -8.882  -23.448 1.00 27.06 ? 19   LEU A CD2 1 ? 
ATOM   146  N N   . GLN A 1 20  ? 2.834   -8.911  -28.799 1.00 24.00 ? 20   GLN A N   1 ? 
ATOM   147  C CA  . GLN A 1 20  ? 2.974   -9.410  -30.193 1.00 28.07 ? 20   GLN A CA  1 ? 
ATOM   148  C C   . GLN A 1 20  ? 3.543   -8.338  -31.130 1.00 26.44 ? 20   GLN A C   1 ? 
ATOM   149  O O   . GLN A 1 20  ? 3.550   -8.587  -32.362 1.00 30.45 ? 20   GLN A O   1 ? 
ATOM   150  C CB  . GLN A 1 20  ? 1.641   -9.931  -30.733 1.00 30.73 ? 20   GLN A CB  1 ? 
ATOM   151  C CG  . GLN A 1 20  ? 1.253   -11.265 -30.126 1.00 36.96 ? 20   GLN A CG  1 ? 
ATOM   152  C CD  . GLN A 1 20  ? 2.076   -12.400 -30.684 1.00 43.10 ? 20   GLN A CD  1 ? 
ATOM   153  O OE1 . GLN A 1 20  ? 3.078   -12.205 -31.378 1.00 49.64 ? 20   GLN A OE1 1 ? 
ATOM   154  N NE2 . GLN A 1 20  ? 1.659   -13.614 -30.365 1.00 49.00 ? 20   GLN A NE2 1 ? 
ATOM   155  N N   . GLU A 1 21  ? 4.082   -7.239  -30.621 1.00 24.65 ? 21   GLU A N   1 ? 
ATOM   156  C CA  . GLU A 1 21  ? 4.672   -6.187  -31.503 1.00 21.50 ? 21   GLU A CA  1 ? 
ATOM   157  C C   . GLU A 1 21  ? 5.936   -6.726  -32.165 1.00 22.89 ? 21   GLU A C   1 ? 
ATOM   158  O O   . GLU A 1 21  ? 6.635   -7.583  -31.621 1.00 22.91 ? 21   GLU A O   1 ? 
ATOM   159  C CB  . GLU A 1 21  ? 4.972   -4.890  -30.745 1.00 21.86 ? 21   GLU A CB  1 ? 
ATOM   160  C CG  . GLU A 1 21  ? 3.739   -4.267  -30.143 1.00 22.71 ? 21   GLU A CG  1 ? 
ATOM   161  C CD  . GLU A 1 21  ? 2.742   -3.666  -31.111 1.00 27.33 ? 21   GLU A CD  1 ? 
ATOM   162  O OE1 . GLU A 1 21  ? 3.098   -3.466  -32.294 1.00 27.99 ? 21   GLU A OE1 1 ? 
ATOM   163  O OE2 . GLU A 1 21  ? 1.606   -3.386  -30.658 1.00 32.30 ? 21   GLU A OE2 1 ? 
ATOM   164  N N   . PRO A 1 22  ? 6.260   -6.257  -33.378 1.00 21.28 ? 22   PRO A N   1 ? 
ATOM   165  C CA  . PRO A 1 22  ? 7.350   -6.848  -34.146 1.00 23.08 ? 22   PRO A CA  1 ? 
ATOM   166  C C   . PRO A 1 22  ? 8.758   -6.574  -33.609 1.00 20.58 ? 22   PRO A C   1 ? 
ATOM   167  O O   . PRO A 1 22  ? 9.630   -7.350  -33.967 1.00 24.98 ? 22   PRO A O   1 ? 
ATOM   168  C CB  . PRO A 1 22  ? 7.218   -6.250  -35.544 1.00 24.41 ? 22   PRO A CB  1 ? 
ATOM   169  C CG  . PRO A 1 22  ? 6.340   -5.031  -35.392 1.00 25.21 ? 22   PRO A CG  1 ? 
ATOM   170  C CD  . PRO A 1 22  ? 5.506   -5.245  -34.144 1.00 22.42 ? 22   PRO A CD  1 ? 
ATOM   171  N N   . THR A 1 23  ? 8.964   -5.513  -32.820 1.00 17.73 ? 23   THR A N   1 ? 
ATOM   172  C CA  . THR A 1 23  ? 10.282  -5.223  -32.218 1.00 16.49 ? 23   THR A CA  1 ? 
ATOM   173  C C   . THR A 1 23  ? 10.119  -4.993  -30.724 1.00 15.27 ? 23   THR A C   1 ? 
ATOM   174  O O   . THR A 1 23  ? 9.004   -4.641  -30.260 1.00 15.69 ? 23   THR A O   1 ? 
ATOM   175  C CB  . THR A 1 23  ? 10.963  -4.000  -32.836 1.00 18.08 ? 23   THR A CB  1 ? 
ATOM   176  O OG1 . THR A 1 23  ? 10.324  -2.803  -32.405 1.00 18.94 ? 23   THR A OG1 1 ? 
ATOM   177  C CG2 . THR A 1 23  ? 10.977  -4.025  -34.349 1.00 19.59 ? 23   THR A CG2 1 ? 
ATOM   178  N N   . VAL A 1 24  ? 11.198  -5.201  -29.993 1.00 13.95 ? 24   VAL A N   1 ? 
ATOM   179  C CA  . VAL A 1 24  ? 11.186  -4.942  -28.527 1.00 13.88 ? 24   VAL A CA  1 ? 
ATOM   180  C C   . VAL A 1 24  ? 10.834  -3.473  -28.274 1.00 14.59 ? 24   VAL A C   1 ? 
ATOM   181  O O   . VAL A 1 24  ? 10.027  -3.182  -27.372 1.00 14.62 ? 24   VAL A O   1 ? 
ATOM   182  C CB  . VAL A 1 24  ? 12.522  -5.357  -27.903 1.00 14.16 ? 24   VAL A CB  1 ? 
ATOM   183  C CG1 . VAL A 1 24  ? 12.691  -4.776  -26.514 1.00 14.57 ? 24   VAL A CG1 1 ? 
ATOM   184  C CG2 . VAL A 1 24  ? 12.651  -6.874  -27.906 1.00 15.21 ? 24   VAL A CG2 1 ? 
ATOM   185  N N   . GLU A 1 25  ? 11.395  -2.531  -29.038 1.00 15.14 ? 25   GLU A N   1 ? 
ATOM   186  C CA  . GLU A 1 25  ? 11.084  -1.107  -28.794 1.00 16.86 ? 25   GLU A CA  1 ? 
ATOM   187  C C   . GLU A 1 25  ? 9.603   -0.825  -29.059 1.00 15.90 ? 25   GLU A C   1 ? 
ATOM   188  O O   . GLU A 1 25  ? 9.042   -0.013  -28.294 1.00 16.18 ? 25   GLU A O   1 ? 
ATOM   189  C CB  . GLU A 1 25  ? 12.036  -0.224  -29.588 1.00 20.68 ? 25   GLU A CB  1 ? 
ATOM   190  C CG  . GLU A 1 25  ? 13.424  -0.184  -28.962 1.00 25.83 ? 25   GLU A CG  1 ? 
ATOM   191  C CD  . GLU A 1 25  ? 13.515  0.226   -27.486 1.00 28.70 ? 25   GLU A CD  1 ? 
ATOM   192  O OE1 . GLU A 1 25  ? 14.464  -0.220  -26.818 1.00 29.45 ? 25   GLU A OE1 1 ? 
ATOM   193  O OE2 . GLU A 1 25  ? 12.650  1.006   -26.993 1.00 34.08 ? 25   GLU A OE2 1 ? 
ATOM   194  N N   . GLN A 1 26  ? 8.988   -1.461  -30.058 1.00 15.35 ? 26   GLN A N   1 ? 
ATOM   195  C CA  . GLN A 1 26  ? 7.532   -1.300  -30.280 1.00 16.02 ? 26   GLN A CA  1 ? 
ATOM   196  C C   . GLN A 1 26  ? 6.741   -1.910  -29.121 1.00 14.83 ? 26   GLN A C   1 ? 
ATOM   197  O O   . GLN A 1 26  ? 5.759   -1.299  -28.729 1.00 14.97 ? 26   GLN A O   1 ? 
ATOM   198  C CB  . GLN A 1 26  ? 7.120   -1.842  -31.640 1.00 18.06 ? 26   GLN A CB  1 ? 
ATOM   199  C CG  . GLN A 1 26  ? 7.590   -0.911  -32.733 1.00 21.55 ? 26   GLN A CG  1 ? 
ATOM   200  C CD  . GLN A 1 26  ? 7.292   -1.473  -34.095 1.00 26.33 ? 26   GLN A CD  1 ? 
ATOM   201  O OE1 . GLN A 1 26  ? 8.200   -1.734  -34.879 1.00 34.40 ? 26   GLN A OE1 1 ? 
ATOM   202  N NE2 . GLN A 1 26  ? 6.017   -1.656  -34.380 1.00 28.94 ? 26   GLN A NE2 1 ? 
ATOM   203  N N   . MET A 1 27  ? 7.190   -3.030  -28.553 1.00 13.75 ? 27   MET A N   1 ? 
ATOM   204  C CA  . MET A 1 27  ? 6.497   -3.613  -27.376 1.00 14.16 ? 27   MET A CA  1 ? 
ATOM   205  C C   . MET A 1 27  ? 6.608   -2.650  -26.187 1.00 12.88 ? 27   MET A C   1 ? 
ATOM   206  O O   . MET A 1 27  ? 5.604   -2.394  -25.510 1.00 13.16 ? 27   MET A O   1 ? 
ATOM   207  C CB  . MET A 1 27  ? 7.108   -4.963  -27.016 1.00 16.29 ? 27   MET A CB  1 ? 
ATOM   208  C CG  . MET A 1 27  ? 6.610   -6.071  -27.901 1.00 19.28 ? 27   MET A CG  1 ? 
ATOM   209  S SD  . MET A 1 27  ? 6.841   -7.586  -26.993 1.00 29.71 ? 27   MET A SD  1 ? 
ATOM   210  C CE  . MET A 1 27  ? 8.570   -7.673  -27.422 1.00 16.30 ? 27   MET A CE  1 ? 
ATOM   211  N N   . ARG A 1 28  ? 7.785   -2.092  -25.957 1.00 11.98 ? 28   ARG A N   1 ? 
ATOM   212  C CA  . ARG A 1 28  ? 8.005   -1.155  -24.835 1.00 12.02 ? 28   ARG A CA  1 ? 
ATOM   213  C C   . ARG A 1 28  ? 7.091   0.060   -25.004 1.00 13.26 ? 28   ARG A C   1 ? 
ATOM   214  O O   . ARG A 1 28  ? 6.420   0.441   -24.037 1.00 12.28 ? 28   ARG A O   1 ? 
ATOM   215  C CB  . ARG A 1 28  ? 9.479   -0.775  -24.716 1.00 11.65 ? 28   ARG A CB  1 ? 
ATOM   216  C CG  . ARG A 1 28  ? 10.360  -1.912  -24.231 1.00 11.39 ? 28   ARG A CG  1 ? 
ATOM   217  C CD  . ARG A 1 28  ? 11.822  -1.542  -24.237 1.00 11.90 ? 28   ARG A CD  1 ? 
ATOM   218  N NE  . ARG A 1 28  ? 12.576  -2.681  -23.722 1.00 11.80 ? 28   ARG A NE  1 ? 
ATOM   219  C CZ  . ARG A 1 28  ? 13.839  -2.942  -23.984 1.00 11.49 ? 28   ARG A CZ  1 ? 
ATOM   220  N NH1 . ARG A 1 28  ? 14.553  -2.161  -24.788 1.00 13.22 ? 28   ARG A NH1 1 ? 
ATOM   221  N NH2 . ARG A 1 28  ? 14.390  -4.020  -23.475 1.00 12.02 ? 28   ARG A NH2 1 ? 
ATOM   222  N N   . ALA A 1 29  ? 7.107   0.663   -26.193 1.00 14.27 ? 29   ALA A N   1 ? 
ATOM   223  C CA  . ALA A 1 29  ? 6.315   1.877   -26.480 1.00 15.55 ? 29   ALA A CA  1 ? 
ATOM   224  C C   . ALA A 1 29  ? 4.824   1.554   -26.401 1.00 15.43 ? 29   ALA A C   1 ? 
ATOM   225  O O   . ALA A 1 29  ? 4.084   2.421   -25.900 1.00 16.66 ? 29   ALA A O   1 ? 
ATOM   226  C CB  . ALA A 1 29  ? 6.682   2.451   -27.833 1.00 16.61 ? 29   ALA A CB  1 ? 
ATOM   227  N N   . GLY A 1 30  ? 4.394   0.374   -26.855 1.00 15.49 ? 30   GLY A N   1 ? 
ATOM   228  C CA  . GLY A 1 30  ? 2.977   -0.045  -26.824 1.00 16.66 ? 30   GLY A CA  1 ? 
ATOM   229  C C   . GLY A 1 30  ? 2.467   -0.135  -25.397 1.00 17.07 ? 30   GLY A C   1 ? 
ATOM   230  O O   . GLY A 1 30  ? 1.345   0.344   -25.096 1.00 17.87 ? 30   GLY A O   1 ? 
ATOM   231  N N   . LEU A 1 31  ? 3.266   -0.687  -24.496 1.00 15.79 ? 31   LEU A N   1 ? 
ATOM   232  C CA  . LEU A 1 31  ? 2.823   -0.793  -23.090 1.00 15.49 ? 31   LEU A CA  1 ? 
ATOM   233  C C   . LEU A 1 31  ? 2.779   0.600   -22.451 1.00 15.91 ? 31   LEU A C   1 ? 
ATOM   234  O O   . LEU A 1 31  ? 1.867   0.844   -21.664 1.00 16.79 ? 31   LEU A O   1 ? 
ATOM   235  C CB  . LEU A 1 31  ? 3.744   -1.740  -22.325 1.00 15.24 ? 31   LEU A CB  1 ? 
ATOM   236  C CG  . LEU A 1 31  ? 3.219   -2.129  -20.941 1.00 15.36 ? 31   LEU A CG  1 ? 
ATOM   237  C CD1 . LEU A 1 31  ? 1.909   -2.890  -21.040 1.00 17.90 ? 31   LEU A CD1 1 ? 
ATOM   238  C CD2 . LEU A 1 31  ? 4.251   -2.958  -20.190 1.00 15.71 ? 31   LEU A CD2 1 ? 
ATOM   239  N N   A GLU A 1 32  ? 3.752   1.472   -22.745 0.50 16.04 ? 32   GLU A N   1 ? 
ATOM   240  N N   B GLU A 1 32  ? 3.746   1.474   -22.746 0.50 17.10 ? 32   GLU A N   1 ? 
ATOM   241  C CA  A GLU A 1 32  ? 3.794   2.852   -22.193 0.50 17.39 ? 32   GLU A CA  1 ? 
ATOM   242  C CA  B GLU A 1 32  ? 3.773   2.846   -22.175 0.50 19.24 ? 32   GLU A CA  1 ? 
ATOM   243  C C   A GLU A 1 32  ? 2.537   3.590   -22.668 0.50 17.42 ? 32   GLU A C   1 ? 
ATOM   244  C C   B GLU A 1 32  ? 2.534   3.596   -22.669 0.50 18.49 ? 32   GLU A C   1 ? 
ATOM   245  O O   A GLU A 1 32  ? 1.902   4.279   -21.851 0.50 18.22 ? 32   GLU A O   1 ? 
ATOM   246  O O   B GLU A 1 32  ? 1.899   4.287   -21.855 0.50 19.25 ? 32   GLU A O   1 ? 
ATOM   247  C CB  A GLU A 1 32  ? 5.078   3.581   -22.592 0.50 18.55 ? 32   GLU A CB  1 ? 
ATOM   248  C CB  B GLU A 1 32  ? 5.093   3.551   -22.478 0.50 21.97 ? 32   GLU A CB  1 ? 
ATOM   249  C CG  A GLU A 1 32  ? 6.342   3.066   -21.905 0.50 19.56 ? 32   GLU A CG  1 ? 
ATOM   250  C CG  B GLU A 1 32  ? 5.969   3.698   -21.236 0.50 25.11 ? 32   GLU A CG  1 ? 
ATOM   251  C CD  A GLU A 1 32  ? 7.263   4.168   -21.399 0.50 20.27 ? 32   GLU A CD  1 ? 
ATOM   252  C CD  B GLU A 1 32  ? 7.433   3.323   -21.391 0.50 27.13 ? 32   GLU A CD  1 ? 
ATOM   253  O OE1 A GLU A 1 32  ? 7.202   5.269   -21.965 0.50 23.46 ? 32   GLU A OE1 1 ? 
ATOM   254  O OE1 B GLU A 1 32  ? 8.095   3.912   -22.275 0.50 30.45 ? 32   GLU A OE1 1 ? 
ATOM   255  O OE2 A GLU A 1 32  ? 8.050   3.924   -20.450 0.50 19.35 ? 32   GLU A OE2 1 ? 
ATOM   256  O OE2 B GLU A 1 32  ? 7.912   2.441   -20.627 0.50 26.66 ? 32   GLU A OE2 1 ? 
ATOM   257  N N   . ALA A 1 33  ? 2.160   3.409   -23.936 1.00 17.57 ? 33   ALA A N   1 ? 
ATOM   258  C CA  . ALA A 1 33  ? 0.952   4.048   -24.514 1.00 19.49 ? 33   ALA A CA  1 ? 
ATOM   259  C C   . ALA A 1 33  ? -0.290  3.586   -23.749 1.00 19.37 ? 33   ALA A C   1 ? 
ATOM   260  O O   . ALA A 1 33  ? -1.139  4.450   -23.393 1.00 19.80 ? 33   ALA A O   1 ? 
ATOM   261  C CB  . ALA A 1 33  ? 0.828   3.729   -25.989 1.00 19.55 ? 33   ALA A CB  1 ? 
ATOM   262  N N   . MET A 1 34  ? -0.414  2.287   -23.498 1.00 17.92 ? 34   MET A N   1 ? 
ATOM   263  C CA  . MET A 1 34  ? -1.569  1.712   -22.774 1.00 19.34 ? 34   MET A CA  1 ? 
ATOM   264  C C   . MET A 1 34  ? -1.594  2.247   -21.335 1.00 20.10 ? 34   MET A C   1 ? 
ATOM   265  O O   . MET A 1 34  ? -2.660  2.715   -20.897 1.00 19.55 ? 34   MET A O   1 ? 
ATOM   266  C CB  . MET A 1 34  ? -1.546  0.188   -22.797 1.00 21.64 ? 34   MET A CB  1 ? 
ATOM   267  C CG  . MET A 1 34  ? -2.899  -0.381  -22.419 1.00 25.60 ? 34   MET A CG  1 ? 
ATOM   268  S SD  . MET A 1 34  ? -2.983  -2.164  -22.409 1.00 29.20 ? 34   MET A SD  1 ? 
ATOM   269  C CE  . MET A 1 34  ? -2.892  -2.544  -24.154 1.00 30.30 ? 34   MET A CE  1 ? 
ATOM   270  N N   . ALA A 1 35  ? -0.458  2.297   -20.644 1.00 18.48 ? 35   ALA A N   1 ? 
ATOM   271  C CA  . ALA A 1 35  ? -0.385  2.749   -19.228 1.00 20.35 ? 35   ALA A CA  1 ? 
ATOM   272  C C   . ALA A 1 35  ? -0.844  4.207   -19.092 1.00 24.33 ? 35   ALA A C   1 ? 
ATOM   273  O O   . ALA A 1 35  ? -1.520  4.491   -18.100 1.00 24.77 ? 35   ALA A O   1 ? 
ATOM   274  C CB  . ALA A 1 35  ? 1.012   2.568   -18.691 1.00 20.49 ? 35   ALA A CB  1 ? 
ATOM   275  N N   . GLN A 1 36  ? -0.489  5.097   -20.029 1.00 28.87 ? 36   GLN A N   1 ? 
ATOM   276  C CA  . GLN A 1 36  ? -0.859  6.544   -19.982 1.00 36.23 ? 36   GLN A CA  1 ? 
ATOM   277  C C   . GLN A 1 36  ? -2.388  6.734   -20.017 1.00 37.53 ? 36   GLN A C   1 ? 
ATOM   278  O O   . GLN A 1 36  ? -2.843  7.846   -19.713 1.00 46.83 ? 36   GLN A O   1 ? 
ATOM   279  C CB  . GLN A 1 36  ? -0.196  7.359   -21.097 1.00 41.38 ? 36   GLN A CB  1 ? 
ATOM   280  C CG  . GLN A 1 36  ? -0.530  8.845   -20.952 1.00 49.08 ? 36   GLN A CG  1 ? 
ATOM   281  C CD  . GLN A 1 36  ? 0.419   9.825   -21.601 1.00 53.63 ? 36   GLN A CD  1 ? 
ATOM   282  O OE1 . GLN A 1 36  ? 1.386   9.454   -22.265 1.00 58.28 ? 36   GLN A OE1 1 ? 
ATOM   283  N NE2 . GLN A 1 36  ? 0.139   11.105  -21.404 1.00 53.63 ? 36   GLN A NE2 1 ? 
ATOM   284  N N   . MET A 1 37  ? -3.170  5.696   -20.304 1.00 37.46 ? 37   MET A N   1 ? 
ATOM   285  C CA  . MET A 1 37  ? -4.659  5.747   -20.293 1.00 39.77 ? 37   MET A CA  1 ? 
ATOM   286  C C   . MET A 1 37  ? -5.199  5.793   -18.851 1.00 40.32 ? 37   MET A C   1 ? 
ATOM   287  O O   . MET A 1 37  ? -6.330  6.287   -18.675 1.00 44.33 ? 37   MET A O   1 ? 
ATOM   288  C CB  . MET A 1 37  ? -5.260  4.528   -20.996 1.00 42.41 ? 37   MET A CB  1 ? 
ATOM   289  C CG  . MET A 1 37  ? -4.836  4.389   -22.447 1.00 46.07 ? 37   MET A CG  1 ? 
ATOM   290  S SD  . MET A 1 37  ? -5.635  5.621   -23.486 1.00 48.36 ? 37   MET A SD  1 ? 
ATOM   291  C CE  . MET A 1 37  ? -7.266  4.881   -23.507 1.00 51.40 ? 37   MET A CE  1 ? 
ATOM   292  N N   . SER A 1 38  ? -4.449  5.278   -17.867 1.00 34.83 ? 38   SER A N   1 ? 
ATOM   293  C CA  . SER A 1 38  ? -4.780  5.316   -16.416 1.00 35.23 ? 38   SER A CA  1 ? 
ATOM   294  C C   . SER A 1 38  ? -3.868  6.327   -15.728 1.00 41.21 ? 38   SER A C   1 ? 
ATOM   295  O O   . SER A 1 38  ? -2.868  5.949   -15.122 1.00 45.72 ? 38   SER A O   1 ? 
ATOM   296  C CB  . SER A 1 38  ? -4.646  3.940   -15.791 1.00 33.53 ? 38   SER A CB  1 ? 
ATOM   297  O OG  . SER A 1 38  ? -5.069  3.937   -14.431 1.00 31.47 ? 38   SER A OG  1 ? 
ATOM   298  N N   . PRO A 1 39  ? -4.187  7.639   -15.787 1.00 42.99 ? 39   PRO A N   1 ? 
ATOM   299  C CA  . PRO A 1 39  ? -3.249  8.690   -15.389 1.00 45.91 ? 39   PRO A CA  1 ? 
ATOM   300  C C   . PRO A 1 39  ? -3.260  8.918   -13.868 1.00 41.89 ? 39   PRO A C   1 ? 
ATOM   301  O O   . PRO A 1 39  ? -4.297  8.715   -13.272 1.00 37.54 ? 39   PRO A O   1 ? 
ATOM   302  C CB  . PRO A 1 39  ? -3.811  9.906   -16.140 1.00 48.29 ? 39   PRO A CB  1 ? 
ATOM   303  C CG  . PRO A 1 39  ? -5.312  9.693   -16.082 1.00 47.55 ? 39   PRO A CG  1 ? 
ATOM   304  C CD  . PRO A 1 39  ? -5.504  8.189   -16.144 1.00 46.77 ? 39   PRO A CD  1 ? 
ATOM   305  N N   . LEU A 1 40  ? -2.116  9.319   -13.297 1.00 45.26 ? 40   LEU A N   1 ? 
ATOM   306  C CA  . LEU A 1 40  ? -1.896  9.441   -11.829 1.00 42.41 ? 40   LEU A CA  1 ? 
ATOM   307  C C   . LEU A 1 40  ? -2.899  10.415  -11.221 1.00 40.06 ? 40   LEU A C   1 ? 
ATOM   308  O O   . LEU A 1 40  ? -3.115  11.497  -11.760 1.00 39.10 ? 40   LEU A O   1 ? 
ATOM   309  C CB  . LEU A 1 40  ? -0.485  9.959   -11.529 1.00 42.78 ? 40   LEU A CB  1 ? 
ATOM   310  C CG  . LEU A 1 40  ? 0.662   8.955   -11.584 1.00 42.11 ? 40   LEU A CG  1 ? 
ATOM   311  C CD1 . LEU A 1 40  ? 1.882   9.527   -10.891 1.00 43.68 ? 40   LEU A CD1 1 ? 
ATOM   312  C CD2 . LEU A 1 40  ? 0.285   7.628   -10.953 1.00 43.31 ? 40   LEU A CD2 1 ? 
ATOM   313  N N   . PRO A 1 41  ? -3.519  10.075  -10.067 1.00 34.07 ? 41   PRO A N   1 ? 
ATOM   314  C CA  . PRO A 1 41  ? -4.155  11.077  -9.212  1.00 30.75 ? 41   PRO A CA  1 ? 
ATOM   315  C C   . PRO A 1 41  ? -3.170  12.187  -8.822  1.00 28.45 ? 41   PRO A C   1 ? 
ATOM   316  O O   . PRO A 1 41  ? -1.986  11.946  -8.718  1.00 27.48 ? 41   PRO A O   1 ? 
ATOM   317  C CB  . PRO A 1 41  ? -4.595  10.266  -7.986  1.00 31.54 ? 41   PRO A CB  1 ? 
ATOM   318  C CG  . PRO A 1 41  ? -4.769  8.854   -8.511  1.00 31.89 ? 41   PRO A CG  1 ? 
ATOM   319  C CD  . PRO A 1 41  ? -3.683  8.709   -9.550  1.00 32.55 ? 41   PRO A CD  1 ? 
ATOM   320  N N   . ALA A 1 42  ? -3.677  13.403  -8.609  1.00 29.23 ? 42   ALA A N   1 ? 
ATOM   321  C CA  . ALA A 1 42  ? -2.847  14.590  -8.320  1.00 28.59 ? 42   ALA A CA  1 ? 
ATOM   322  C C   . ALA A 1 42  ? -2.192  14.477  -6.936  1.00 26.67 ? 42   ALA A C   1 ? 
ATOM   323  O O   . ALA A 1 42  ? -1.167  15.148  -6.725  1.00 28.57 ? 42   ALA A O   1 ? 
ATOM   324  C CB  . ALA A 1 42  ? -3.684  15.838  -8.430  1.00 29.31 ? 42   ALA A CB  1 ? 
ATOM   325  N N   . ASP A 1 43  ? -2.727  13.647  -6.031  1.00 25.36 ? 43   ASP A N   1 ? 
ATOM   326  C CA  . ASP A 1 43  ? -2.201  13.517  -4.641  1.00 25.22 ? 43   ASP A CA  1 ? 
ATOM   327  C C   . ASP A 1 43  ? -1.005  12.547  -4.587  1.00 25.75 ? 43   ASP A C   1 ? 
ATOM   328  O O   . ASP A 1 43  ? -0.407  12.403  -3.514  1.00 24.31 ? 43   ASP A O   1 ? 
ATOM   329  C CB  . ASP A 1 43  ? -3.329  13.148  -3.675  1.00 27.15 ? 43   ASP A CB  1 ? 
ATOM   330  C CG  . ASP A 1 43  ? -3.931  11.771  -3.865  1.00 27.30 ? 43   ASP A CG  1 ? 
ATOM   331  O OD1 . ASP A 1 43  ? -3.636  11.139  -4.896  1.00 33.72 ? 43   ASP A OD1 1 ? 
ATOM   332  O OD2 . ASP A 1 43  ? -4.699  11.344  -2.991  1.00 27.62 ? 43   ASP A OD2 1 ? 
ATOM   333  N N   . VAL A 1 44  ? -0.622  11.928  -5.701  1.00 24.41 ? 44   VAL A N   1 ? 
ATOM   334  C CA  . VAL A 1 44  ? 0.570   11.033  -5.743  1.00 23.60 ? 44   VAL A CA  1 ? 
ATOM   335  C C   . VAL A 1 44  ? 1.828   11.894  -5.815  1.00 24.64 ? 44   VAL A C   1 ? 
ATOM   336  O O   . VAL A 1 44  ? 1.904   12.777  -6.683  1.00 25.55 ? 44   VAL A O   1 ? 
ATOM   337  C CB  . VAL A 1 44  ? 0.487   10.043  -6.918  1.00 23.57 ? 44   VAL A CB  1 ? 
ATOM   338  C CG1 . VAL A 1 44  ? 1.695   9.119   -6.944  1.00 23.96 ? 44   VAL A CG1 1 ? 
ATOM   339  C CG2 . VAL A 1 44  ? -0.789  9.233   -6.888  1.00 22.54 ? 44   VAL A CG2 1 ? 
ATOM   340  N N   . GLU A 1 45  ? 2.791   11.642  -4.937  1.00 24.09 ? 45   GLU A N   1 ? 
ATOM   341  C CA  . GLU A 1 45  ? 4.146   12.234  -4.986  1.00 28.36 ? 45   GLU A CA  1 ? 
ATOM   342  C C   . GLU A 1 45  ? 5.130   11.173  -5.487  1.00 28.25 ? 45   GLU A C   1 ? 
ATOM   343  O O   . GLU A 1 45  ? 5.192   10.105  -4.875  1.00 25.08 ? 45   GLU A O   1 ? 
ATOM   344  C CB  . GLU A 1 45  ? 4.536   12.773  -3.608  1.00 34.11 ? 45   GLU A CB  1 ? 
ATOM   345  C CG  . GLU A 1 45  ? 5.622   13.835  -3.645  1.00 43.28 ? 45   GLU A CG  1 ? 
ATOM   346  C CD  . GLU A 1 45  ? 5.155   15.244  -3.989  1.00 48.73 ? 45   GLU A CD  1 ? 
ATOM   347  O OE1 . GLU A 1 45  ? 4.394   15.399  -4.967  1.00 56.28 ? 45   GLU A OE1 1 ? 
ATOM   348  O OE2 . GLU A 1 45  ? 5.564   16.190  -3.278  1.00 59.18 ? 45   GLU A OE2 1 ? 
ATOM   349  N N   . LEU A 1 46  ? 5.836   11.468  -6.579  1.00 25.01 ? 46   LEU A N   1 ? 
ATOM   350  C CA  . LEU A 1 46  ? 6.915   10.628  -7.148  1.00 26.16 ? 46   LEU A CA  1 ? 
ATOM   351  C C   . LEU A 1 46  ? 8.230   11.357  -6.961  1.00 26.73 ? 46   LEU A C   1 ? 
ATOM   352  O O   . LEU A 1 46  ? 8.302   12.529  -7.366  1.00 29.04 ? 46   LEU A O   1 ? 
ATOM   353  C CB  . LEU A 1 46  ? 6.677   10.393  -8.639  1.00 30.81 ? 46   LEU A CB  1 ? 
ATOM   354  C CG  . LEU A 1 46  ? 5.276   9.951   -9.006  1.00 34.38 ? 46   LEU A CG  1 ? 
ATOM   355  C CD1 . LEU A 1 46  ? 5.057   10.143  -10.500 1.00 39.13 ? 46   LEU A CD1 1 ? 
ATOM   356  C CD2 . LEU A 1 46  ? 5.059   8.505   -8.589  1.00 36.72 ? 46   LEU A CD2 1 ? 
ATOM   357  N N   . THR A 1 47  ? 9.235   10.695  -6.395  1.00 23.25 ? 47   THR A N   1 ? 
ATOM   358  C CA  . THR A 1 47  ? 10.608  11.217  -6.226  1.00 24.27 ? 47   THR A CA  1 ? 
ATOM   359  C C   . THR A 1 47  ? 11.596  10.227  -6.822  1.00 24.77 ? 47   THR A C   1 ? 
ATOM   360  O O   . THR A 1 47  ? 11.662  9.080   -6.350  1.00 21.75 ? 47   THR A O   1 ? 
ATOM   361  C CB  . THR A 1 47  ? 10.947  11.424  -4.748  1.00 24.68 ? 47   THR A CB  1 ? 
ATOM   362  O OG1 . THR A 1 47  ? 9.904   12.233  -4.208  1.00 26.60 ? 47   THR A OG1 1 ? 
ATOM   363  C CG2 . THR A 1 47  ? 12.299  12.058  -4.517  1.00 26.39 ? 47   THR A CG2 1 ? 
ATOM   364  N N   A THR A 1 48  ? 12.300  10.606  -7.889  0.50 23.33 ? 48   THR A N   1 ? 
ATOM   365  N N   B THR A 1 48  ? 12.436  10.720  -7.724  0.50 23.58 ? 48   THR A N   1 ? 
ATOM   366  C CA  A THR A 1 48  ? 13.352  9.752   -8.490  0.50 24.05 ? 48   THR A CA  1 ? 
ATOM   367  C CA  B THR A 1 48  ? 13.520  9.958   -8.376  0.50 24.12 ? 48   THR A CA  1 ? 
ATOM   368  C C   A THR A 1 48  ? 14.488  9.650   -7.467  0.50 23.16 ? 48   THR A C   1 ? 
ATOM   369  C C   B THR A 1 48  ? 14.613  9.688   -7.343  0.50 24.31 ? 48   THR A C   1 ? 
ATOM   370  O O   A THR A 1 48  ? 14.661  10.630  -6.698  0.50 24.54 ? 48   THR A O   1 ? 
ATOM   371  O O   B THR A 1 48  ? 14.935  10.618  -6.562  0.50 24.66 ? 48   THR A O   1 ? 
ATOM   372  C CB  A THR A 1 48  ? 13.794  10.278  -9.860  0.50 24.90 ? 48   THR A CB  1 ? 
ATOM   373  C CB  B THR A 1 48  ? 14.049  10.753  -9.575  0.50 25.23 ? 48   THR A CB  1 ? 
ATOM   374  O OG1 A THR A 1 48  ? 14.611  11.424  -9.615  0.50 27.13 ? 48   THR A OG1 1 ? 
ATOM   375  O OG1 B THR A 1 48  ? 12.924  11.222  -10.315 0.50 25.41 ? 48   THR A OG1 1 ? 
ATOM   376  C CG2 A THR A 1 48  ? 12.629  10.626  -10.760 0.50 25.91 ? 48   THR A CG2 1 ? 
ATOM   377  C CG2 B THR A 1 48  ? 14.960  9.940   -10.461 0.50 25.47 ? 48   THR A CG2 1 ? 
ATOM   378  N N   A VAL A 1 49  ? 15.158  8.492   -7.395  0.50 22.21 ? 49   VAL A N   1 ? 
ATOM   379  N N   B VAL A 1 49  ? 15.155  8.472   -7.302  0.50 23.11 ? 49   VAL A N   1 ? 
ATOM   380  C CA  A VAL A 1 49  ? 16.249  8.198   -6.422  0.50 22.02 ? 49   VAL A CA  1 ? 
ATOM   381  C CA  B VAL A 1 49  ? 16.255  8.130   -6.362  0.50 23.36 ? 49   VAL A CA  1 ? 
ATOM   382  C C   A VAL A 1 49  ? 17.233  7.229   -7.082  0.50 22.28 ? 49   VAL A C   1 ? 
ATOM   383  C C   B VAL A 1 49  ? 17.238  7.217   -7.082  0.50 23.04 ? 49   VAL A C   1 ? 
ATOM   384  O O   A VAL A 1 49  ? 16.812  6.470   -7.981  0.50 22.13 ? 49   VAL A O   1 ? 
ATOM   385  O O   B VAL A 1 49  ? 16.821  6.479   -8.000  0.50 22.74 ? 49   VAL A O   1 ? 
ATOM   386  C CB  A VAL A 1 49  ? 15.704  7.650   -5.081  0.50 22.56 ? 49   VAL A CB  1 ? 
ATOM   387  C CB  B VAL A 1 49  ? 15.727  7.489   -5.063  0.50 24.67 ? 49   VAL A CB  1 ? 
ATOM   388  C CG1 A VAL A 1 49  ? 15.186  6.217   -5.182  0.50 21.48 ? 49   VAL A CG1 1 ? 
ATOM   389  C CG1 B VAL A 1 49  ? 15.430  8.539   -4.007  0.50 24.41 ? 49   VAL A CG1 1 ? 
ATOM   390  C CG2 A VAL A 1 49  ? 16.749  7.755   -3.985  0.50 22.41 ? 49   VAL A CG2 1 ? 
ATOM   391  C CG2 B VAL A 1 49  ? 14.512  6.615   -5.330  0.50 24.74 ? 49   VAL A CG2 1 ? 
ATOM   392  N N   . ASP A 1 50  ? 18.503  7.286   -6.680  1.00 21.98 ? 50   ASP A N   1 ? 
ATOM   393  C CA  . ASP A 1 50  ? 19.510  6.257   -7.001  1.00 22.93 ? 50   ASP A CA  1 ? 
ATOM   394  C C   . ASP A 1 50  ? 19.474  5.274   -5.832  1.00 22.99 ? 50   ASP A C   1 ? 
ATOM   395  O O   . ASP A 1 50  ? 19.996  5.620   -4.752  1.00 22.27 ? 50   ASP A O   1 ? 
ATOM   396  C CB  . ASP A 1 50  ? 20.898  6.871   -7.192  1.00 26.25 ? 50   ASP A CB  1 ? 
ATOM   397  C CG  . ASP A 1 50  ? 21.976  5.840   -7.444  1.00 30.00 ? 50   ASP A CG  1 ? 
ATOM   398  O OD1 . ASP A 1 50  ? 21.635  4.673   -7.733  1.00 31.91 ? 50   ASP A OD1 1 ? 
ATOM   399  O OD2 . ASP A 1 50  ? 23.153  6.212   -7.367  1.00 35.22 ? 50   ASP A OD2 1 ? 
ATOM   400  N N   . ALA A 1 51  ? 18.800  4.136   -6.010  1.00 19.86 ? 51   ALA A N   1 ? 
ATOM   401  C CA  . ALA A 1 51  ? 18.646  3.091   -4.975  1.00 21.19 ? 51   ALA A CA  1 ? 
ATOM   402  C C   . ALA A 1 51  ? 19.874  2.178   -5.018  1.00 21.46 ? 51   ALA A C   1 ? 
ATOM   403  O O   . ALA A 1 51  ? 19.776  1.031   -5.417  1.00 22.11 ? 51   ALA A O   1 ? 
ATOM   404  C CB  . ALA A 1 51  ? 17.341  2.361   -5.169  1.00 21.40 ? 51   ALA A CB  1 ? 
ATOM   405  N N   . GLY A 1 52  ? 21.020  2.708   -4.590  1.00 23.38 ? 52   GLY A N   1 ? 
ATOM   406  C CA  . GLY A 1 52  ? 22.281  1.966   -4.469  1.00 23.98 ? 52   GLY A CA  1 ? 
ATOM   407  C C   . GLY A 1 52  ? 22.832  1.500   -5.804  1.00 23.67 ? 52   GLY A C   1 ? 
ATOM   408  O O   . GLY A 1 52  ? 23.379  0.398   -5.838  1.00 27.10 ? 52   GLY A O   1 ? 
ATOM   409  N N   . GLY A 1 53  ? 22.648  2.286   -6.872  1.00 23.30 ? 53   GLY A N   1 ? 
ATOM   410  C CA  . GLY A 1 53  ? 23.115  1.969   -8.234  1.00 23.01 ? 53   GLY A CA  1 ? 
ATOM   411  C C   . GLY A 1 53  ? 22.006  1.423   -9.123  1.00 22.57 ? 53   GLY A C   1 ? 
ATOM   412  O O   . GLY A 1 53  ? 22.300  0.993   -10.261 1.00 23.70 ? 53   GLY A O   1 ? 
ATOM   413  N N   . VAL A 1 54  ? 20.771  1.401   -8.629  1.00 18.72 ? 54   VAL A N   1 ? 
ATOM   414  C CA  . VAL A 1 54  ? 19.568  1.008   -9.412  1.00 17.29 ? 54   VAL A CA  1 ? 
ATOM   415  C C   . VAL A 1 54  ? 18.656  2.213   -9.429  1.00 15.59 ? 54   VAL A C   1 ? 
ATOM   416  O O   . VAL A 1 54  ? 18.293  2.713   -8.379  1.00 16.08 ? 54   VAL A O   1 ? 
ATOM   417  C CB  . VAL A 1 54  ? 18.841  -0.196  -8.775  1.00 18.04 ? 54   VAL A CB  1 ? 
ATOM   418  C CG1 . VAL A 1 54  ? 17.622  -0.593  -9.571  1.00 18.64 ? 54   VAL A CG1 1 ? 
ATOM   419  C CG2 . VAL A 1 54  ? 19.796  -1.365  -8.601  1.00 18.69 ? 54   VAL A CG2 1 ? 
ATOM   420  N N   . PRO A 1 55  ? 18.229  2.744   -10.593 1.00 14.82 ? 55   PRO A N   1 ? 
ATOM   421  C CA  . PRO A 1 55  ? 17.321  3.873   -10.601 1.00 15.74 ? 55   PRO A CA  1 ? 
ATOM   422  C C   . PRO A 1 55  ? 15.967  3.452   -10.032 1.00 15.92 ? 55   PRO A C   1 ? 
ATOM   423  O O   . PRO A 1 55  ? 15.506  2.330   -10.245 1.00 15.88 ? 55   PRO A O   1 ? 
ATOM   424  C CB  . PRO A 1 55  ? 17.153  4.294   -12.065 1.00 16.03 ? 55   PRO A CB  1 ? 
ATOM   425  C CG  . PRO A 1 55  ? 18.237  3.557   -12.766 1.00 16.24 ? 55   PRO A CG  1 ? 
ATOM   426  C CD  . PRO A 1 55  ? 18.574  2.323   -11.952 1.00 16.36 ? 55   PRO A CD  1 ? 
ATOM   427  N N   . GLY A 1 56  ? 15.350  4.370   -9.317  1.00 16.57 ? 56   GLY A N   1 ? 
ATOM   428  C CA  . GLY A 1 56  ? 14.037  4.086   -8.739  1.00 17.70 ? 56   GLY A CA  1 ? 
ATOM   429  C C   . GLY A 1 56  ? 13.236  5.336   -8.566  1.00 18.03 ? 56   GLY A C   1 ? 
ATOM   430  O O   . GLY A 1 56  ? 13.734  6.443   -8.879  1.00 19.27 ? 56   GLY A O   1 ? 
ATOM   431  N N   . ALA A 1 57  ? 11.982  5.133   -8.213  1.00 17.15 ? 57   ALA A N   1 ? 
ATOM   432  C CA  . ALA A 1 57  ? 11.069  6.211   -7.813  1.00 17.23 ? 57   ALA A CA  1 ? 
ATOM   433  C C   . ALA A 1 57  ? 10.410  5.816   -6.502  1.00 17.48 ? 57   ALA A C   1 ? 
ATOM   434  O O   . ALA A 1 57  ? 9.831   4.720   -6.418  1.00 15.93 ? 57   ALA A O   1 ? 
ATOM   435  C CB  . ALA A 1 57  ? 10.048  6.463   -8.888  1.00 18.57 ? 57   ALA A CB  1 ? 
ATOM   436  N N   . TRP A 1 58  ? 10.496  6.694   -5.514  1.00 16.81 ? 58   TRP A N   1 ? 
ATOM   437  C CA  . TRP A 1 58  ? 9.583   6.657   -4.357  1.00 17.21 ? 58   TRP A CA  1 ? 
ATOM   438  C C   . TRP A 1 58  ? 8.184   7.071   -4.803  1.00 17.99 ? 58   TRP A C   1 ? 
ATOM   439  O O   . TRP A 1 58  ? 8.027   8.129   -5.460  1.00 18.31 ? 58   TRP A O   1 ? 
ATOM   440  C CB  . TRP A 1 58  ? 10.074  7.601   -3.274  1.00 17.16 ? 58   TRP A CB  1 ? 
ATOM   441  C CG  . TRP A 1 58  ? 11.239  7.107   -2.501  1.00 18.87 ? 58   TRP A CG  1 ? 
ATOM   442  C CD1 . TRP A 1 58  ? 12.504  7.612   -2.453  1.00 20.01 ? 58   TRP A CD1 1 ? 
ATOM   443  C CD2 . TRP A 1 58  ? 11.195  6.010   -1.583  1.00 17.80 ? 58   TRP A CD2 1 ? 
ATOM   444  N NE1 . TRP A 1 58  ? 13.262  6.890   -1.571  1.00 20.84 ? 58   TRP A NE1 1 ? 
ATOM   445  C CE2 . TRP A 1 58  ? 12.481  5.905   -1.022  1.00 19.21 ? 58   TRP A CE2 1 ? 
ATOM   446  C CE3 . TRP A 1 58  ? 10.193  5.106   -1.206  1.00 17.93 ? 58   TRP A CE3 1 ? 
ATOM   447  C CZ2 . TRP A 1 58  ? 12.797  4.916   -0.090  1.00 18.95 ? 58   TRP A CZ2 1 ? 
ATOM   448  C CZ3 . TRP A 1 58  ? 10.510  4.141   -0.272  1.00 18.28 ? 58   TRP A CZ3 1 ? 
ATOM   449  C CH2 . TRP A 1 58  ? 11.782  4.066   0.281   1.00 17.48 ? 58   TRP A CH2 1 ? 
ATOM   450  N N   . VAL A 1 59  ? 7.192   6.287   -4.444  1.00 15.69 ? 59   VAL A N   1 ? 
ATOM   451  C CA  . VAL A 1 59  ? 5.770   6.555   -4.714  1.00 16.74 ? 59   VAL A CA  1 ? 
ATOM   452  C C   . VAL A 1 59  ? 5.090   6.684   -3.354  1.00 19.34 ? 59   VAL A C   1 ? 
ATOM   453  O O   . VAL A 1 59  ? 5.099   5.714   -2.576  1.00 17.19 ? 59   VAL A O   1 ? 
ATOM   454  C CB  . VAL A 1 59  ? 5.128   5.467   -5.593  1.00 17.84 ? 59   VAL A CB  1 ? 
ATOM   455  C CG1 . VAL A 1 59  ? 3.656   5.709   -5.831  1.00 19.63 ? 59   VAL A CG1 1 ? 
ATOM   456  C CG2 . VAL A 1 59  ? 5.852   5.291   -6.917  1.00 18.58 ? 59   VAL A CG2 1 ? 
ATOM   457  N N   . ARG A 1 60  ? 4.537   7.865   -3.088  1.00 20.22 ? 60   ARG A N   1 ? 
ATOM   458  C CA  . ARG A 1 60  ? 3.934   8.221   -1.785  1.00 22.80 ? 60   ARG A CA  1 ? 
ATOM   459  C C   . ARG A 1 60  ? 2.531   8.782   -2.050  1.00 20.29 ? 60   ARG A C   1 ? 
ATOM   460  O O   . ARG A 1 60  ? 2.323   9.436   -3.094  1.00 20.23 ? 60   ARG A O   1 ? 
ATOM   461  C CB  . ARG A 1 60  ? 4.888   9.218   -1.128  1.00 26.90 ? 60   ARG A CB  1 ? 
ATOM   462  C CG  . ARG A 1 60  ? 4.590   9.603   0.311   1.00 33.93 ? 60   ARG A CG  1 ? 
ATOM   463  C CD  . ARG A 1 60  ? 5.591   10.664  0.726   1.00 38.21 ? 60   ARG A CD  1 ? 
ATOM   464  N NE  . ARG A 1 60  ? 5.767   10.724  2.171   1.00 45.55 ? 60   ARG A NE  1 ? 
ATOM   465  C CZ  . ARG A 1 60  ? 6.918   10.546  2.821   1.00 46.79 ? 60   ARG A CZ  1 ? 
ATOM   466  N NH1 . ARG A 1 60  ? 8.047   10.311  2.172   1.00 50.02 ? 60   ARG A NH1 1 ? 
ATOM   467  N NH2 . ARG A 1 60  ? 6.936   10.634  4.137   1.00 46.54 ? 60   ARG A NH2 1 ? 
ATOM   468  N N   . VAL A 1 61  ? 1.590   8.489   -1.169  1.00 19.15 ? 61   VAL A N   1 ? 
ATOM   469  C CA  . VAL A 1 61  ? 0.218   9.053   -1.209  1.00 18.76 ? 61   VAL A CA  1 ? 
ATOM   470  C C   . VAL A 1 61  ? -0.062  9.630   0.176   1.00 19.41 ? 61   VAL A C   1 ? 
ATOM   471  O O   . VAL A 1 61  ? 0.724   9.412   1.102   1.00 17.52 ? 61   VAL A O   1 ? 
ATOM   472  C CB  . VAL A 1 61  ? -0.825  8.009   -1.634  1.00 19.37 ? 61   VAL A CB  1 ? 
ATOM   473  C CG1 . VAL A 1 61  ? -0.614  7.557   -3.075  1.00 19.62 ? 61   VAL A CG1 1 ? 
ATOM   474  C CG2 . VAL A 1 61  ? -0.868  6.820   -0.696  1.00 19.53 ? 61   VAL A CG2 1 ? 
ATOM   475  N N   . PRO A 1 62  ? -1.121  10.452  0.335   1.00 21.14 ? 62   PRO A N   1 ? 
ATOM   476  C CA  . PRO A 1 62  ? -1.322  11.164  1.590   1.00 21.04 ? 62   PRO A CA  1 ? 
ATOM   477  C C   . PRO A 1 62  ? -1.293  10.276  2.839   1.00 21.53 ? 62   PRO A C   1 ? 
ATOM   478  O O   . PRO A 1 62  ? -0.753  10.741  3.836   1.00 22.59 ? 62   PRO A O   1 ? 
ATOM   479  C CB  . PRO A 1 62  ? -2.697  11.807  1.399   1.00 21.97 ? 62   PRO A CB  1 ? 
ATOM   480  C CG  . PRO A 1 62  ? -2.713  12.102  -0.066  1.00 23.05 ? 62   PRO A CG  1 ? 
ATOM   481  C CD  . PRO A 1 62  ? -2.096  10.858  -0.690  1.00 22.41 ? 62   PRO A CD  1 ? 
ATOM   482  N N   . GLU A 1 63  ? -1.848  9.063   2.785   1.00 21.47 ? 63   GLU A N   1 ? 
ATOM   483  C CA  . GLU A 1 63  ? -1.900  8.214   4.010   1.00 22.55 ? 63   GLU A CA  1 ? 
ATOM   484  C C   . GLU A 1 63  ? -0.733  7.222   4.051   1.00 21.87 ? 63   GLU A C   1 ? 
ATOM   485  O O   . GLU A 1 63  ? -0.794  6.284   4.894   1.00 21.94 ? 63   GLU A O   1 ? 
ATOM   486  C CB  . GLU A 1 63  ? -3.259  7.538   4.159   1.00 25.17 ? 63   GLU A CB  1 ? 
ATOM   487  C CG  . GLU A 1 63  ? -4.431  8.513   4.218   1.00 25.32 ? 63   GLU A CG  1 ? 
ATOM   488  C CD  . GLU A 1 63  ? -4.269  9.649   5.219   1.00 26.93 ? 63   GLU A CD  1 ? 
ATOM   489  O OE1 . GLU A 1 63  ? -3.714  9.372   6.330   1.00 25.64 ? 63   GLU A OE1 1 ? 
ATOM   490  O OE2 . GLU A 1 63  ? -4.695  10.805  4.900   1.00 28.82 ? 63   GLU A OE2 1 ? 
ATOM   491  N N   . SER A 1 64  ? 0.322   7.395   3.250   1.00 20.56 ? 64   SER A N   1 ? 
ATOM   492  C CA  . SER A 1 64  ? 1.546   6.544   3.361   1.00 19.26 ? 64   SER A CA  1 ? 
ATOM   493  C C   . SER A 1 64  ? 2.203   6.658   4.748   1.00 19.38 ? 64   SER A C   1 ? 
ATOM   494  O O   . SER A 1 64  ? 2.599   7.764   5.094   1.00 21.77 ? 64   SER A O   1 ? 
ATOM   495  C CB  . SER A 1 64  ? 2.539   6.883   2.301   1.00 20.51 ? 64   SER A CB  1 ? 
ATOM   496  O OG  . SER A 1 64  ? 2.056   6.513   1.021   1.00 20.18 ? 64   SER A OG  1 ? 
ATOM   497  N N   . ASP A 1 65  ? 2.332   5.550   5.498   1.00 17.94 ? 65   ASP A N   1 ? 
ATOM   498  C CA  . ASP A 1 65  ? 3.193   5.476   6.710   1.00 18.99 ? 65   ASP A CA  1 ? 
ATOM   499  C C   . ASP A 1 65  ? 4.621   5.551   6.206   1.00 19.50 ? 65   ASP A C   1 ? 
ATOM   500  O O   . ASP A 1 65  ? 5.043   4.678   5.431   1.00 19.15 ? 65   ASP A O   1 ? 
ATOM   501  C CB  . ASP A 1 65  ? 2.920   4.213   7.535   1.00 19.41 ? 65   ASP A CB  1 ? 
ATOM   502  C CG  . ASP A 1 65  ? 3.796   4.041   8.773   1.00 20.75 ? 65   ASP A CG  1 ? 
ATOM   503  O OD1 . ASP A 1 65  ? 4.920   4.546   8.785   1.00 20.90 ? 65   ASP A OD1 1 ? 
ATOM   504  O OD2 . ASP A 1 65  ? 3.352   3.353   9.728   1.00 25.23 ? 65   ASP A OD2 1 ? 
ATOM   505  N N   . PRO A 1 66  ? 5.399   6.579   6.606   1.00 19.38 ? 66   PRO A N   1 ? 
ATOM   506  C CA  . PRO A 1 66  ? 6.716   6.808   6.021   1.00 20.29 ? 66   PRO A CA  1 ? 
ATOM   507  C C   . PRO A 1 66  ? 7.740   5.712   6.371   1.00 21.02 ? 66   PRO A C   1 ? 
ATOM   508  O O   . PRO A 1 66  ? 8.757   5.656   5.720   1.00 24.06 ? 66   PRO A O   1 ? 
ATOM   509  C CB  . PRO A 1 66  ? 7.117   8.176   6.596   1.00 22.56 ? 66   PRO A CB  1 ? 
ATOM   510  C CG  . PRO A 1 66  ? 6.357   8.264   7.907   1.00 21.85 ? 66   PRO A CG  1 ? 
ATOM   511  C CD  . PRO A 1 66  ? 5.035   7.596   7.618   1.00 20.26 ? 66   PRO A CD  1 ? 
ATOM   512  N N   . ASP A 1 67  ? 7.441   4.862   7.359   1.00 17.35 ? 67   ASP A N   1 ? 
ATOM   513  C CA  . ASP A 1 67  ? 8.403   3.830   7.826   1.00 17.34 ? 67   ASP A CA  1 ? 
ATOM   514  C C   . ASP A 1 67  ? 8.002   2.450   7.289   1.00 16.50 ? 67   ASP A C   1 ? 
ATOM   515  O O   . ASP A 1 67  ? 8.711   1.489   7.615   1.00 18.67 ? 67   ASP A O   1 ? 
ATOM   516  C CB  . ASP A 1 67  ? 8.488   3.835   9.353   1.00 17.07 ? 67   ASP A CB  1 ? 
ATOM   517  C CG  . ASP A 1 67  ? 9.191   5.080   9.861   1.00 19.52 ? 67   ASP A CG  1 ? 
ATOM   518  O OD1 . ASP A 1 67  ? 10.348  5.304   9.455   1.00 19.84 ? 67   ASP A OD1 1 ? 
ATOM   519  O OD2 . ASP A 1 67  ? 8.556   5.830   10.658  1.00 22.16 ? 67   ASP A OD2 1 ? 
ATOM   520  N N   . ARG A 1 68  ? 6.930   2.345   6.504   1.00 14.89 ? 68   ARG A N   1 ? 
ATOM   521  C CA  . ARG A 1 68  ? 6.555   1.064   5.857   1.00 14.58 ? 68   ARG A CA  1 ? 
ATOM   522  C C   . ARG A 1 68  ? 6.847   1.179   4.369   1.00 14.12 ? 68   ARG A C   1 ? 
ATOM   523  O O   . ARG A 1 68  ? 6.495   2.192   3.763   1.00 15.04 ? 68   ARG A O   1 ? 
ATOM   524  C CB  . ARG A 1 68  ? 5.098   0.713   6.094   1.00 15.60 ? 68   ARG A CB  1 ? 
ATOM   525  C CG  . ARG A 1 68  ? 4.809   0.417   7.559   1.00 17.31 ? 68   ARG A CG  1 ? 
ATOM   526  C CD  . ARG A 1 68  ? 3.347   0.236   7.845   1.00 18.96 ? 68   ARG A CD  1 ? 
ATOM   527  N NE  . ARG A 1 68  ? 3.241   -0.142  9.249   1.00 21.28 ? 68   ARG A NE  1 ? 
ATOM   528  C CZ  . ARG A 1 68  ? 2.156   -0.660  9.796   1.00 22.43 ? 68   ARG A CZ  1 ? 
ATOM   529  N NH1 . ARG A 1 68  ? 1.067   -0.845  9.068   1.00 22.38 ? 68   ARG A NH1 1 ? 
ATOM   530  N NH2 . ARG A 1 68  ? 2.172   -0.986  11.084  1.00 24.64 ? 68   ARG A NH2 1 ? 
ATOM   531  N N   A VAL A 1 69  ? 7.429   0.128   3.804   0.50 12.25 ? 69   VAL A N   1 ? 
ATOM   532  N N   B VAL A 1 69  ? 7.514   0.187   3.785   0.50 13.62 ? 69   VAL A N   1 ? 
ATOM   533  C CA  A VAL A 1 69  ? 7.943   0.174   2.416   0.50 11.58 ? 69   VAL A CA  1 ? 
ATOM   534  C CA  B VAL A 1 69  ? 7.936   0.295   2.361   0.50 13.61 ? 69   VAL A CA  1 ? 
ATOM   535  C C   A VAL A 1 69  ? 7.609   -1.135  1.702   0.50 11.48 ? 69   VAL A C   1 ? 
ATOM   536  C C   B VAL A 1 69  ? 7.766   -1.052  1.661   0.50 12.63 ? 69   VAL A C   1 ? 
ATOM   537  O O   A VAL A 1 69  ? 7.772   -2.221  2.254   0.50 10.48 ? 69   VAL A O   1 ? 
ATOM   538  O O   B VAL A 1 69  ? 8.313   -2.060  2.179   0.50 10.63 ? 69   VAL A O   1 ? 
ATOM   539  C CB  A VAL A 1 69  ? 9.452   0.448   2.388   0.50 11.15 ? 69   VAL A CB  1 ? 
ATOM   540  C CB  B VAL A 1 69  ? 9.379   0.800   2.205   0.50 15.14 ? 69   VAL A CB  1 ? 
ATOM   541  C CG1 A VAL A 1 69  ? 9.958   0.536   0.939   0.50 10.77 ? 69   VAL A CG1 1 ? 
ATOM   542  C CG1 B VAL A 1 69  ? 9.554   2.247   2.630   0.50 16.29 ? 69   VAL A CG1 1 ? 
ATOM   543  C CG2 A VAL A 1 69  ? 9.810   1.693   3.190   0.50 11.58 ? 69   VAL A CG2 1 ? 
ATOM   544  C CG2 B VAL A 1 69  ? 10.370  -0.093  2.918   0.50 15.83 ? 69   VAL A CG2 1 ? 
ATOM   545  N N   . VAL A 1 70  ? 7.127   -1.009  0.488   1.00 11.57 ? 70   VAL A N   1 ? 
ATOM   546  C CA  . VAL A 1 70  ? 7.068   -2.131  -0.475  1.00 11.82 ? 70   VAL A CA  1 ? 
ATOM   547  C C   . VAL A 1 70  ? 8.101   -1.853  -1.554  1.00 11.49 ? 70   VAL A C   1 ? 
ATOM   548  O O   . VAL A 1 70  ? 8.021   -0.788  -2.197  1.00 11.83 ? 70   VAL A O   1 ? 
ATOM   549  C CB  . VAL A 1 70  ? 5.675   -2.290  -1.079  1.00 12.47 ? 70   VAL A CB  1 ? 
ATOM   550  C CG1 . VAL A 1 70  ? 5.689   -3.295  -2.225  1.00 13.10 ? 70   VAL A CG1 1 ? 
ATOM   551  C CG2 . VAL A 1 70  ? 4.688   -2.678  0.003   1.00 13.63 ? 70   VAL A CG2 1 ? 
ATOM   552  N N   . LEU A 1 71  ? 9.022   -2.790  -1.763  1.00 11.02 ? 71   LEU A N   1 ? 
ATOM   553  C CA  . LEU A 1 71  ? 9.881   -2.789  -2.969  1.00 10.40 ? 71   LEU A CA  1 ? 
ATOM   554  C C   . LEU A 1 71  ? 9.064   -3.443  -4.085  1.00 10.51 ? 71   LEU A C   1 ? 
ATOM   555  O O   . LEU A 1 71  ? 8.685   -4.609  -3.947  1.00 10.84 ? 71   LEU A O   1 ? 
ATOM   556  C CB  . LEU A 1 71  ? 11.175  -3.551  -2.686  1.00 10.75 ? 71   LEU A CB  1 ? 
ATOM   557  C CG  . LEU A 1 71  ? 12.039  -3.855  -3.906  1.00 10.95 ? 71   LEU A CG  1 ? 
ATOM   558  C CD1 . LEU A 1 71  ? 12.520  -2.578  -4.559  1.00 11.56 ? 71   LEU A CD1 1 ? 
ATOM   559  C CD2 . LEU A 1 71  ? 13.208  -4.735  -3.520  1.00 11.55 ? 71   LEU A CD2 1 ? 
ATOM   560  N N   . TYR A 1 72  ? 8.721   -2.675  -5.119  1.00 10.04 ? 72   TYR A N   1 ? 
ATOM   561  C CA  . TYR A 1 72  ? 7.808   -3.138  -6.187  1.00 10.45 ? 72   TYR A CA  1 ? 
ATOM   562  C C   . TYR A 1 72  ? 8.631   -3.458  -7.448  1.00 10.92 ? 72   TYR A C   1 ? 
ATOM   563  O O   . TYR A 1 72  ? 9.393   -2.581  -7.926  1.00 10.85 ? 72   TYR A O   1 ? 
ATOM   564  C CB  . TYR A 1 72  ? 6.690   -2.132  -6.503  1.00 11.32 ? 72   TYR A CB  1 ? 
ATOM   565  C CG  . TYR A 1 72  ? 5.634   -2.834  -7.305  1.00 11.70 ? 72   TYR A CG  1 ? 
ATOM   566  C CD1 . TYR A 1 72  ? 5.769   -2.972  -8.674  1.00 12.96 ? 72   TYR A CD1 1 ? 
ATOM   567  C CD2 . TYR A 1 72  ? 4.616   -3.551  -6.686  1.00 12.16 ? 72   TYR A CD2 1 ? 
ATOM   568  C CE1 . TYR A 1 72  ? 4.861   -3.724  -9.419  1.00 13.22 ? 72   TYR A CE1 1 ? 
ATOM   569  C CE2 . TYR A 1 72  ? 3.699   -4.294  -7.411  1.00 12.94 ? 72   TYR A CE2 1 ? 
ATOM   570  C CZ  . TYR A 1 72  ? 3.831   -4.397  -8.783  1.00 12.61 ? 72   TYR A CZ  1 ? 
ATOM   571  O OH  . TYR A 1 72  ? 2.959   -5.185  -9.476  1.00 13.77 ? 72   TYR A OH  1 ? 
ATOM   572  N N   . LEU A 1 73  ? 8.454   -4.665  -7.948  1.00 10.39 ? 73   LEU A N   1 ? 
ATOM   573  C CA  . LEU A 1 73  ? 9.143   -5.233  -9.127  1.00 10.88 ? 73   LEU A CA  1 ? 
ATOM   574  C C   . LEU A 1 73  ? 8.146   -5.397  -10.267 1.00 10.59 ? 73   LEU A C   1 ? 
ATOM   575  O O   . LEU A 1 73  ? 7.286   -6.286  -10.237 1.00 10.30 ? 73   LEU A O   1 ? 
ATOM   576  C CB  . LEU A 1 73  ? 9.801   -6.548  -8.710  1.00 10.47 ? 73   LEU A CB  1 ? 
ATOM   577  C CG  . LEU A 1 73  ? 10.695  -6.442  -7.483  1.00 10.85 ? 73   LEU A CG  1 ? 
ATOM   578  C CD1 . LEU A 1 73  ? 11.268  -7.792  -7.096  1.00 11.30 ? 73   LEU A CD1 1 ? 
ATOM   579  C CD2 . LEU A 1 73  ? 11.805  -5.420  -7.678  1.00 10.69 ? 73   LEU A CD2 1 ? 
ATOM   580  N N   . HIS A 1 74  ? 8.246   -4.542  -11.288 1.00 10.24 ? 74   HIS A N   1 ? 
ATOM   581  C CA  . HIS A 1 74  ? 7.228   -4.503  -12.362 1.00 10.66 ? 74   HIS A CA  1 ? 
ATOM   582  C C   . HIS A 1 74  ? 7.352   -5.722  -13.277 1.00 10.31 ? 74   HIS A C   1 ? 
ATOM   583  O O   . HIS A 1 74  ? 8.439   -6.325  -13.383 1.00 10.77 ? 74   HIS A O   1 ? 
ATOM   584  C CB  . HIS A 1 74  ? 7.362   -3.211  -13.168 1.00 10.45 ? 74   HIS A CB  1 ? 
ATOM   585  C CG  . HIS A 1 74  ? 8.604   -3.141  -14.006 1.00 11.17 ? 74   HIS A CG  1 ? 
ATOM   586  N ND1 . HIS A 1 74  ? 8.676   -3.762  -15.241 1.00 11.10 ? 74   HIS A ND1 1 ? 
ATOM   587  C CD2 . HIS A 1 74  ? 9.754   -2.448  -13.864 1.00 11.59 ? 74   HIS A CD2 1 ? 
ATOM   588  C CE1 . HIS A 1 74  ? 9.852   -3.496  -15.781 1.00 10.41 ? 74   HIS A CE1 1 ? 
ATOM   589  N NE2 . HIS A 1 74  ? 10.512  -2.694  -14.991 1.00 10.78 ? 74   HIS A NE2 1 ? 
ATOM   590  N N   . GLY A 1 75  ? 6.259   -6.052  -13.939 1.00 10.47 ? 75   GLY A N   1 ? 
ATOM   591  C CA  . GLY A 1 75  ? 6.195   -7.105  -14.964 1.00 10.59 ? 75   GLY A CA  1 ? 
ATOM   592  C C   . GLY A 1 75  ? 6.533   -6.599  -16.347 1.00 10.65 ? 75   GLY A C   1 ? 
ATOM   593  O O   . GLY A 1 75  ? 6.894   -5.408  -16.501 1.00 11.01 ? 75   GLY A O   1 ? 
ATOM   594  N N   . GLY A 1 76  ? 6.471   -7.496  -17.308 1.00 10.51 ? 76   GLY A N   1 ? 
ATOM   595  C CA  . GLY A 1 76  ? 6.882   -7.205  -18.695 1.00 10.03 ? 76   GLY A CA  1 ? 
ATOM   596  C C   . GLY A 1 76  ? 7.865   -8.216  -19.244 1.00 10.24 ? 76   GLY A C   1 ? 
ATOM   597  O O   . GLY A 1 76  ? 8.665   -7.872  -20.127 1.00 10.78 ? 76   GLY A O   1 ? 
ATOM   598  N N   . GLY A 1 77  ? 7.840   -9.453  -18.757 1.00 10.17 ? 77   GLY A N   1 ? 
ATOM   599  C CA  . GLY A 1 77  ? 8.630   -10.536 -19.350 1.00 9.41  ? 77   GLY A CA  1 ? 
ATOM   600  C C   . GLY A 1 77  ? 10.128  -10.390 -19.167 1.00 9.36  ? 77   GLY A C   1 ? 
ATOM   601  O O   . GLY A 1 77  ? 10.841  -11.102 -19.873 1.00 10.68 ? 77   GLY A O   1 ? 
ATOM   602  N N   . TYR A 1 78  ? 10.578  -9.524  -18.251 1.00 9.02  ? 78   TYR A N   1 ? 
ATOM   603  C CA  . TYR A 1 78  ? 12.003  -9.167  -18.043 1.00 9.29  ? 78   TYR A CA  1 ? 
ATOM   604  C C   . TYR A 1 78  ? 12.514  -8.335  -19.211 1.00 10.03 ? 78   TYR A C   1 ? 
ATOM   605  O O   . TYR A 1 78  ? 13.717  -8.108  -19.279 1.00 10.64 ? 78   TYR A O   1 ? 
ATOM   606  C CB  . TYR A 1 78  ? 12.866  -10.417 -17.830 1.00 9.84  ? 78   TYR A CB  1 ? 
ATOM   607  C CG  . TYR A 1 78  ? 12.558  -11.188 -16.568 1.00 9.41  ? 78   TYR A CG  1 ? 
ATOM   608  C CD1 . TYR A 1 78  ? 12.937  -10.690 -15.334 1.00 10.14 ? 78   TYR A CD1 1 ? 
ATOM   609  C CD2 . TYR A 1 78  ? 11.899  -12.404 -16.607 1.00 10.44 ? 78   TYR A CD2 1 ? 
ATOM   610  C CE1 . TYR A 1 78  ? 12.673  -11.373 -14.162 1.00 10.96 ? 78   TYR A CE1 1 ? 
ATOM   611  C CE2 . TYR A 1 78  ? 11.655  -13.112 -15.432 1.00 10.19 ? 78   TYR A CE2 1 ? 
ATOM   612  C CZ  . TYR A 1 78  ? 12.042  -12.592 -14.212 1.00 10.24 ? 78   TYR A CZ  1 ? 
ATOM   613  O OH  . TYR A 1 78  ? 11.823  -13.287 -13.040 1.00 12.70 ? 78   TYR A OH  1 ? 
ATOM   614  N N   . VAL A 1 79  ? 11.629  -7.890  -20.091 1.00 9.67  ? 79   VAL A N   1 ? 
ATOM   615  C CA  . VAL A 1 79  ? 12.010  -7.213  -21.367 1.00 9.70  ? 79   VAL A CA  1 ? 
ATOM   616  C C   . VAL A 1 79  ? 11.355  -5.838  -21.482 1.00 10.04 ? 79   VAL A C   1 ? 
ATOM   617  O O   . VAL A 1 79  ? 11.998  -4.925  -22.027 1.00 11.12 ? 79   VAL A O   1 ? 
ATOM   618  C CB  . VAL A 1 79  ? 11.652  -8.111  -22.558 1.00 10.29 ? 79   VAL A CB  1 ? 
ATOM   619  C CG1 . VAL A 1 79  ? 11.831  -7.432  -23.906 1.00 10.73 ? 79   VAL A CG1 1 ? 
ATOM   620  C CG2 . VAL A 1 79  ? 12.441  -9.392  -22.524 1.00 10.65 ? 79   VAL A CG2 1 ? 
ATOM   621  N N   . ILE A 1 80  ? 10.107  -5.678  -21.040 1.00 10.19 ? 80   ILE A N   1 ? 
ATOM   622  C CA  . ILE A 1 80  ? 9.378   -4.383  -21.155 1.00 11.29 ? 80   ILE A CA  1 ? 
ATOM   623  C C   . ILE A 1 80  ? 8.898   -3.943  -19.777 1.00 10.76 ? 80   ILE A C   1 ? 
ATOM   624  O O   . ILE A 1 80  ? 9.204   -4.623  -18.762 1.00 10.39 ? 80   ILE A O   1 ? 
ATOM   625  C CB  . ILE A 1 80  ? 8.249   -4.483  -22.201 1.00 11.56 ? 80   ILE A CB  1 ? 
ATOM   626  C CG1 . ILE A 1 80  ? 7.025   -5.262  -21.693 1.00 11.50 ? 80   ILE A CG1 1 ? 
ATOM   627  C CG2 . ILE A 1 80  ? 8.783   -5.041  -23.513 1.00 10.97 ? 80   ILE A CG2 1 ? 
ATOM   628  C CD1 . ILE A 1 80  ? 5.878   -5.294  -22.713 1.00 13.61 ? 80   ILE A CD1 1 ? 
ATOM   629  N N   . GLY A 1 81  ? 8.194   -2.822  -19.746 1.00 10.98 ? 81   GLY A N   1 ? 
ATOM   630  C CA  . GLY A 1 81  ? 7.767   -2.201  -18.492 1.00 10.68 ? 81   GLY A CA  1 ? 
ATOM   631  C C   . GLY A 1 81  ? 8.790   -1.196  -18.014 1.00 11.33 ? 81   GLY A C   1 ? 
ATOM   632  O O   . GLY A 1 81  ? 9.993   -1.228  -18.407 1.00 12.68 ? 81   GLY A O   1 ? 
ATOM   633  N N   . SER A 1 82  ? 8.352   -0.301  -17.149 1.00 12.46 ? 82   SER A N   1 ? 
ATOM   634  C CA  . SER A 1 82  ? 9.167   0.814   -16.657 1.00 12.94 ? 82   SER A CA  1 ? 
ATOM   635  C C   . SER A 1 82  ? 8.493   1.442   -15.445 1.00 12.80 ? 82   SER A C   1 ? 
ATOM   636  O O   . SER A 1 82  ? 7.366   1.074   -15.116 1.00 12.42 ? 82   SER A O   1 ? 
ATOM   637  C CB  . SER A 1 82  ? 9.339   1.848   -17.755 1.00 13.79 ? 82   SER A CB  1 ? 
ATOM   638  O OG  . SER A 1 82  ? 8.101   2.495   -18.010 1.00 15.77 ? 82   SER A OG  1 ? 
ATOM   639  N N   . ILE A 1 83  ? 9.143   2.451   -14.895 1.00 14.92 ? 83   ILE A N   1 ? 
ATOM   640  C CA  . ILE A 1 83  ? 8.504   3.332   -13.885 1.00 15.44 ? 83   ILE A CA  1 ? 
ATOM   641  C C   . ILE A 1 83  ? 7.203   3.907   -14.462 1.00 15.67 ? 83   ILE A C   1 ? 
ATOM   642  O O   . ILE A 1 83  ? 6.208   3.942   -13.736 1.00 16.19 ? 83   ILE A O   1 ? 
ATOM   643  C CB  . ILE A 1 83  ? 9.514   4.391   -13.402 1.00 17.53 ? 83   ILE A CB  1 ? 
ATOM   644  C CG1 . ILE A 1 83  ? 10.546  3.699   -12.507 1.00 18.22 ? 83   ILE A CG1 1 ? 
ATOM   645  C CG2 . ILE A 1 83  ? 8.793   5.537   -12.691 1.00 19.25 ? 83   ILE A CG2 1 ? 
ATOM   646  C CD1 . ILE A 1 83  ? 11.774  4.524   -12.168 1.00 20.20 ? 83   ILE A CD1 1 ? 
ATOM   647  N N   . ARG A 1 84  ? 7.177   4.289   -15.734 1.00 15.25 ? 84   ARG A N   1 ? 
ATOM   648  C CA  . ARG A 1 84  ? 5.973   4.905   -16.330 1.00 16.75 ? 84   ARG A CA  1 ? 
ATOM   649  C C   . ARG A 1 84  ? 4.842   3.879   -16.443 1.00 16.50 ? 84   ARG A C   1 ? 
ATOM   650  O O   . ARG A 1 84  ? 3.675   4.276   -16.253 1.00 17.29 ? 84   ARG A O   1 ? 
ATOM   651  C CB  . ARG A 1 84  ? 6.287   5.539   -17.687 1.00 19.13 ? 84   ARG A CB  1 ? 
ATOM   652  C CG  . ARG A 1 84  ? 6.999   6.879   -17.561 1.00 22.16 ? 84   ARG A CG  1 ? 
ATOM   653  C CD  . ARG A 1 84  ? 7.857   7.250   -18.768 1.00 22.23 ? 84   ARG A CD  1 ? 
ATOM   654  N NE  . ARG A 1 84  ? 8.912   6.261   -18.928 1.00 23.67 ? 84   ARG A NE  1 ? 
ATOM   655  C CZ  . ARG A 1 84  ? 9.964   6.151   -18.121 1.00 22.17 ? 84   ARG A CZ  1 ? 
ATOM   656  N NH1 . ARG A 1 84  ? 10.825  5.161   -18.285 1.00 23.46 ? 84   ARG A NH1 1 ? 
ATOM   657  N NH2 . ARG A 1 84  ? 10.151  7.023   -17.145 1.00 22.28 ? 84   ARG A NH2 1 ? 
ATOM   658  N N   . THR A 1 85  ? 5.110   2.614   -16.780 1.00 13.43 ? 85   THR A N   1 ? 
ATOM   659  C CA  . THR A 1 85  ? 4.015   1.646   -16.995 1.00 12.50 ? 85   THR A CA  1 ? 
ATOM   660  C C   . THR A 1 85  ? 3.384   1.266   -15.656 1.00 12.03 ? 85   THR A C   1 ? 
ATOM   661  O O   . THR A 1 85  ? 2.195   0.936   -15.660 1.00 12.88 ? 85   THR A O   1 ? 
ATOM   662  C CB  . THR A 1 85  ? 4.468   0.396   -17.749 1.00 12.99 ? 85   THR A CB  1 ? 
ATOM   663  O OG1 . THR A 1 85  ? 5.488   -0.309  -17.057 1.00 12.88 ? 85   THR A OG1 1 ? 
ATOM   664  C CG2 . THR A 1 85  ? 5.002   0.759   -19.108 1.00 13.11 ? 85   THR A CG2 1 ? 
ATOM   665  N N   . HIS A 1 86  ? 4.156   1.247   -14.572 1.00 12.48 ? 86   HIS A N   1 ? 
ATOM   666  C CA  . HIS A 1 86  ? 3.695   0.644   -13.300 1.00 12.62 ? 86   HIS A CA  1 ? 
ATOM   667  C C   . HIS A 1 86  ? 3.532   1.662   -12.177 1.00 13.43 ? 86   HIS A C   1 ? 
ATOM   668  O O   . HIS A 1 86  ? 3.135   1.248   -11.080 1.00 13.24 ? 86   HIS A O   1 ? 
ATOM   669  C CB  . HIS A 1 86  ? 4.626   -0.505  -12.901 1.00 12.21 ? 86   HIS A CB  1 ? 
ATOM   670  C CG  . HIS A 1 86  ? 4.332   -1.754  -13.642 1.00 12.53 ? 86   HIS A CG  1 ? 
ATOM   671  N ND1 . HIS A 1 86  ? 4.633   -1.894  -14.986 1.00 12.49 ? 86   HIS A ND1 1 ? 
ATOM   672  C CD2 . HIS A 1 86  ? 3.783   -2.921  -13.236 1.00 11.81 ? 86   HIS A CD2 1 ? 
ATOM   673  C CE1 . HIS A 1 86  ? 4.291   -3.114  -15.369 1.00 12.33 ? 86   HIS A CE1 1 ? 
ATOM   674  N NE2 . HIS A 1 86  ? 3.776   -3.778  -14.310 1.00 12.24 ? 86   HIS A NE2 1 ? 
ATOM   675  N N   . ARG A 1 87  ? 3.772   2.950   -12.405 1.00 13.13 ? 87   ARG A N   1 ? 
ATOM   676  C CA  . ARG A 1 87  ? 3.625   3.930   -11.303 1.00 14.47 ? 87   ARG A CA  1 ? 
ATOM   677  C C   . ARG A 1 87  ? 2.168   3.977   -10.846 1.00 13.90 ? 87   ARG A C   1 ? 
ATOM   678  O O   . ARG A 1 87  ? 1.957   4.203   -9.628  1.00 14.94 ? 87   ARG A O   1 ? 
ATOM   679  C CB  . ARG A 1 87  ? 4.156   5.306   -11.687 1.00 15.72 ? 87   ARG A CB  1 ? 
ATOM   680  C CG  . ARG A 1 87  ? 3.499   5.925   -12.898 1.00 18.51 ? 87   ARG A CG  1 ? 
ATOM   681  C CD  . ARG A 1 87  ? 4.243   7.210   -13.223 1.00 21.00 ? 87   ARG A CD  1 ? 
ATOM   682  N NE  . ARG A 1 87  ? 3.714   7.725   -14.471 1.00 24.09 ? 87   ARG A NE  1 ? 
ATOM   683  C CZ  . ARG A 1 87  ? 4.294   8.670   -15.202 1.00 29.38 ? 87   ARG A CZ  1 ? 
ATOM   684  N NH1 . ARG A 1 87  ? 5.419   9.228   -14.788 1.00 32.35 ? 87   ARG A NH1 1 ? 
ATOM   685  N NH2 . ARG A 1 87  ? 3.752   9.039   -16.349 1.00 32.18 ? 87   ARG A NH2 1 ? 
ATOM   686  N N   . ASP A 1 88  ? 1.182   3.739   -11.709 1.00 14.33 ? 88   ASP A N   1 ? 
ATOM   687  C CA  . ASP A 1 88  ? -0.237  3.784   -11.257 1.00 14.92 ? 88   ASP A CA  1 ? 
ATOM   688  C C   . ASP A 1 88  ? -0.536  2.577   -10.352 1.00 15.23 ? 88   ASP A C   1 ? 
ATOM   689  O O   . ASP A 1 88  ? -1.163  2.740   -9.300  1.00 17.05 ? 88   ASP A O   1 ? 
ATOM   690  C CB  . ASP A 1 88  ? -1.231  3.828   -12.409 1.00 17.58 ? 88   ASP A CB  1 ? 
ATOM   691  C CG  . ASP A 1 88  ? -2.666  3.878   -11.917 1.00 19.53 ? 88   ASP A CG  1 ? 
ATOM   692  O OD1 . ASP A 1 88  ? -2.997  4.841   -11.180 1.00 20.97 ? 88   ASP A OD1 1 ? 
ATOM   693  O OD2 . ASP A 1 88  ? -3.424  2.962   -12.249 1.00 22.98 ? 88   ASP A OD2 1 ? 
ATOM   694  N N   . LEU A 1 89  ? -0.127  1.376   -10.734 1.00 13.83 ? 89   LEU A N   1 ? 
ATOM   695  C CA  . LEU A 1 89  ? -0.333  0.209   -9.856  1.00 14.89 ? 89   LEU A CA  1 ? 
ATOM   696  C C   . LEU A 1 89  ? 0.416   0.453   -8.544  1.00 14.41 ? 89   LEU A C   1 ? 
ATOM   697  O O   . LEU A 1 89  ? -0.138  0.131   -7.460  1.00 15.21 ? 89   LEU A O   1 ? 
ATOM   698  C CB  . LEU A 1 89  ? 0.149   -1.048  -10.585 1.00 14.93 ? 89   LEU A CB  1 ? 
ATOM   699  C CG  . LEU A 1 89  ? -0.033  -2.360  -9.841  1.00 16.10 ? 89   LEU A CG  1 ? 
ATOM   700  C CD1 . LEU A 1 89  ? -1.441  -2.520  -9.299  1.00 16.66 ? 89   LEU A CD1 1 ? 
ATOM   701  C CD2 . LEU A 1 89  ? 0.321   -3.523  -10.755 1.00 17.18 ? 89   LEU A CD2 1 ? 
ATOM   702  N N   . ALA A 1 90  ? 1.628   1.002   -8.596  1.00 14.41 ? 90   ALA A N   1 ? 
ATOM   703  C CA  . ALA A 1 90  ? 2.428   1.275   -7.381  1.00 14.68 ? 90   ALA A CA  1 ? 
ATOM   704  C C   . ALA A 1 90  ? 1.628   2.193   -6.434  1.00 14.77 ? 90   ALA A C   1 ? 
ATOM   705  O O   . ALA A 1 90  ? 1.587   1.918   -5.204  1.00 15.26 ? 90   ALA A O   1 ? 
ATOM   706  C CB  . ALA A 1 90  ? 3.769   1.857   -7.734  1.00 14.63 ? 90   ALA A CB  1 ? 
ATOM   707  N N   . GLN A 1 91  ? 1.027   3.272   -6.954  1.00 14.47 ? 91   GLN A N   1 ? 
ATOM   708  C CA  . GLN A 1 91  ? 0.358   4.255   -6.062  1.00 14.66 ? 91   GLN A CA  1 ? 
ATOM   709  C C   . GLN A 1 91  ? -0.910  3.603   -5.493  1.00 14.93 ? 91   GLN A C   1 ? 
ATOM   710  O O   . GLN A 1 91  ? -1.226  3.838   -4.319  1.00 15.69 ? 91   GLN A O   1 ? 
ATOM   711  C CB  . GLN A 1 91  ? 0.132   5.592   -6.772  1.00 15.79 ? 91   GLN A CB  1 ? 
ATOM   712  C CG  . GLN A 1 91  ? -0.930  5.590   -7.865  1.00 17.25 ? 91   GLN A CG  1 ? 
ATOM   713  C CD  . GLN A 1 91  ? -2.356  5.780   -7.412  1.00 18.92 ? 91   GLN A CD  1 ? 
ATOM   714  O OE1 . GLN A 1 91  ? -2.615  6.152   -6.269  1.00 19.29 ? 91   GLN A OE1 1 ? 
ATOM   715  N NE2 . GLN A 1 91  ? -3.297  5.500   -8.303  1.00 20.11 ? 91   GLN A NE2 1 ? 
ATOM   716  N N   . ARG A 1 92  ? -1.598  2.763   -6.253  1.00 13.43 ? 92   ARG A N   1 ? 
ATOM   717  C CA  . ARG A 1 92  ? -2.818  2.073   -5.750  1.00 14.35 ? 92   ARG A CA  1 ? 
ATOM   718  C C   . ARG A 1 92  ? -2.444  1.138   -4.590  1.00 14.86 ? 92   ARG A C   1 ? 
ATOM   719  O O   . ARG A 1 92  ? -3.198  1.060   -3.594  1.00 16.08 ? 92   ARG A O   1 ? 
ATOM   720  C CB  . ARG A 1 92  ? -3.510  1.286   -6.858  1.00 15.24 ? 92   ARG A CB  1 ? 
ATOM   721  C CG  . ARG A 1 92  ? -4.086  2.172   -7.950  1.00 16.77 ? 92   ARG A CG  1 ? 
ATOM   722  C CD  . ARG A 1 92  ? -4.771  1.358   -9.018  1.00 18.25 ? 92   ARG A CD  1 ? 
ATOM   723  N NE  . ARG A 1 92  ? -5.202  2.307   -10.029 1.00 19.95 ? 92   ARG A NE  1 ? 
ATOM   724  C CZ  . ARG A 1 92  ? -6.317  3.022   -9.966  1.00 23.33 ? 92   ARG A CZ  1 ? 
ATOM   725  N NH1 . ARG A 1 92  ? -7.199  2.821   -9.002  1.00 24.02 ? 92   ARG A NH1 1 ? 
ATOM   726  N NH2 . ARG A 1 92  ? -6.568  3.913   -10.910 1.00 25.76 ? 92   ARG A NH2 1 ? 
ATOM   727  N N   . ILE A 1 93  ? -1.317  0.452   -4.682  1.00 13.15 ? 93   ILE A N   1 ? 
ATOM   728  C CA  . ILE A 1 93  ? -0.837  -0.417  -3.569  1.00 14.79 ? 93   ILE A CA  1 ? 
ATOM   729  C C   . ILE A 1 93  ? -0.418  0.471   -2.389  1.00 14.41 ? 93   ILE A C   1 ? 
ATOM   730  O O   . ILE A 1 93  ? -0.774  0.130   -1.241  1.00 14.62 ? 93   ILE A O   1 ? 
ATOM   731  C CB  . ILE A 1 93  ? 0.287   -1.344  -4.071  1.00 14.37 ? 93   ILE A CB  1 ? 
ATOM   732  C CG1 . ILE A 1 93  ? -0.313  -2.373  -5.033  1.00 14.99 ? 93   ILE A CG1 1 ? 
ATOM   733  C CG2 . ILE A 1 93  ? 1.032   -1.972  -2.899  1.00 14.92 ? 93   ILE A CG2 1 ? 
ATOM   734  C CD1 . ILE A 1 93  ? 0.697   -3.154  -5.842  1.00 15.83 ? 93   ILE A CD1 1 ? 
ATOM   735  N N   . ALA A 1 94  ? 0.301   1.571   -2.624  1.00 14.47 ? 94   ALA A N   1 ? 
ATOM   736  C CA  . ALA A 1 94  ? 0.724   2.514   -1.562  1.00 14.34 ? 94   ALA A CA  1 ? 
ATOM   737  C C   . ALA A 1 94  ? -0.509  2.956   -0.779  1.00 15.18 ? 94   ALA A C   1 ? 
ATOM   738  O O   . ALA A 1 94  ? -0.470  3.026   0.469   1.00 15.52 ? 94   ALA A O   1 ? 
ATOM   739  C CB  . ALA A 1 94  ? 1.417   3.703   -2.156  1.00 15.42 ? 94   ALA A CB  1 ? 
ATOM   740  N N   . ARG A 1 95  ? -1.591  3.216   -1.501  1.00 15.80 ? 95   ARG A N   1 ? 
ATOM   741  C CA  . ARG A 1 95  ? -2.852  3.742   -0.924  1.00 17.69 ? 95   ARG A CA  1 ? 
ATOM   742  C C   . ARG A 1 95  ? -3.534  2.647   -0.105  1.00 18.78 ? 95   ARG A C   1 ? 
ATOM   743  O O   . ARG A 1 95  ? -3.985  2.935   1.040   1.00 20.07 ? 95   ARG A O   1 ? 
ATOM   744  C CB  . ARG A 1 95  ? -3.714  4.247   -2.078  1.00 20.57 ? 95   ARG A CB  1 ? 
ATOM   745  C CG  . ARG A 1 95  ? -4.831  5.207   -1.705  1.00 23.77 ? 95   ARG A CG  1 ? 
ATOM   746  C CD  . ARG A 1 95  ? -5.552  5.652   -2.978  1.00 25.03 ? 95   ARG A CD  1 ? 
ATOM   747  N NE  . ARG A 1 95  ? -4.698  6.396   -3.898  1.00 24.65 ? 95   ARG A NE  1 ? 
ATOM   748  C CZ  . ARG A 1 95  ? -4.467  7.711   -3.851  1.00 26.79 ? 95   ARG A CZ  1 ? 
ATOM   749  N NH1 . ARG A 1 95  ? -3.678  8.281   -4.744  1.00 25.38 ? 95   ARG A NH1 1 ? 
ATOM   750  N NH2 . ARG A 1 95  ? -5.010  8.455   -2.901  1.00 27.15 ? 95   ARG A NH2 1 ? 
ATOM   751  N N   . ALA A 1 96  ? -3.582  1.427   -0.624  1.00 16.82 ? 96   ALA A N   1 ? 
ATOM   752  C CA  . ALA A 1 96  ? -4.311  0.316   0.025   1.00 15.87 ? 96   ALA A CA  1 ? 
ATOM   753  C C   . ALA A 1 96  ? -3.531  -0.160  1.256   1.00 15.95 ? 96   ALA A C   1 ? 
ATOM   754  O O   . ALA A 1 96  ? -4.171  -0.499  2.271   1.00 16.62 ? 96   ALA A O   1 ? 
ATOM   755  C CB  . ALA A 1 96  ? -4.569  -0.819  -0.930  1.00 15.62 ? 96   ALA A CB  1 ? 
ATOM   756  N N   . ALA A 1 97  ? -2.210  -0.243  1.165   1.00 15.03 ? 97   ALA A N   1 ? 
ATOM   757  C CA  . ALA A 1 97  ? -1.326  -0.762  2.238   1.00 15.32 ? 97   ALA A CA  1 ? 
ATOM   758  C C   . ALA A 1 97  ? -0.898  0.371   3.184   1.00 15.68 ? 97   ALA A C   1 ? 
ATOM   759  O O   . ALA A 1 97  ? -0.220  0.080   4.188   1.00 16.96 ? 97   ALA A O   1 ? 
ATOM   760  C CB  . ALA A 1 97  ? -0.129  -1.431  1.616   1.00 15.95 ? 97   ALA A CB  1 ? 
ATOM   761  N N   . ARG A 1 98  ? -1.229  1.620   2.863   1.00 16.55 ? 98   ARG A N   1 ? 
ATOM   762  C CA  . ARG A 1 98  ? -0.825  2.832   3.626   1.00 17.05 ? 98   ARG A CA  1 ? 
ATOM   763  C C   . ARG A 1 98  ? 0.687   2.828   3.875   1.00 16.24 ? 98   ARG A C   1 ? 
ATOM   764  O O   . ARG A 1 98  ? 1.141   2.939   5.011   1.00 15.49 ? 98   ARG A O   1 ? 
ATOM   765  C CB  . ARG A 1 98  ? -1.672  2.913   4.895   1.00 20.60 ? 98   ARG A CB  1 ? 
ATOM   766  C CG  . ARG A 1 98  ? -3.145  3.106   4.582   1.00 23.72 ? 98   ARG A CG  1 ? 
ATOM   767  C CD  . ARG A 1 98  ? -4.020  3.480   5.761   1.00 30.73 ? 98   ARG A CD  1 ? 
ATOM   768  N NE  . ARG A 1 98  ? -4.606  2.375   6.519   1.00 37.84 ? 98   ARG A NE  1 ? 
ATOM   769  C CZ  . ARG A 1 98  ? -5.646  1.622   6.143   1.00 40.21 ? 98   ARG A CZ  1 ? 
ATOM   770  N NH1 . ARG A 1 98  ? -6.205  1.771   4.952   1.00 45.16 ? 98   ARG A NH1 1 ? 
ATOM   771  N NH2 . ARG A 1 98  ? -6.087  0.674   6.951   1.00 42.00 ? 98   ARG A NH2 1 ? 
ATOM   772  N N   . CYS A 1 99  ? 1.465   2.727   2.803   1.00 15.13 ? 99   CYS A N   1 ? 
ATOM   773  C CA  . CYS A 1 99  ? 2.931   2.623   2.858   1.00 15.23 ? 99   CYS A CA  1 ? 
ATOM   774  C C   . CYS A 1 99  ? 3.544   3.426   1.718   1.00 13.81 ? 99   CYS A C   1 ? 
ATOM   775  O O   . CYS A 1 99  ? 2.772   3.959   0.871   1.00 15.33 ? 99   CYS A O   1 ? 
ATOM   776  C CB  . CYS A 1 99  ? 3.358   1.163   2.750   1.00 14.67 ? 99   CYS A CB  1 ? 
ATOM   777  S SG  . CYS A 1 99  ? 2.992   0.429   1.126   1.00 16.40 ? 99   CYS A SG  1 ? 
ATOM   778  N N   . ARG A 1 100 ? 4.864   3.527   1.729   1.00 13.59 ? 100  ARG A N   1 ? 
ATOM   779  C CA  . ARG A 1 100 ? 5.642   4.070   0.601   1.00 15.03 ? 100  ARG A CA  1 ? 
ATOM   780  C C   . ARG A 1 100 ? 5.992   2.889   -0.300  1.00 15.11 ? 100  ARG A C   1 ? 
ATOM   781  O O   . ARG A 1 100 ? 6.103   1.741   0.198   1.00 14.87 ? 100  ARG A O   1 ? 
ATOM   782  C CB  . ARG A 1 100 ? 6.917   4.763   1.074   1.00 17.47 ? 100  ARG A CB  1 ? 
ATOM   783  C CG  . ARG A 1 100 ? 6.692   6.002   1.925   1.00 21.46 ? 100  ARG A CG  1 ? 
ATOM   784  C CD  . ARG A 1 100 ? 8.003   6.762   2.028   1.00 24.34 ? 100  ARG A CD  1 ? 
ATOM   785  N NE  . ARG A 1 100 ? 8.973   6.075   2.866   1.00 25.27 ? 100  ARG A NE  1 ? 
ATOM   786  C CZ  . ARG A 1 100 ? 10.292  6.271   2.838   1.00 28.44 ? 100  ARG A CZ  1 ? 
ATOM   787  N NH1 . ARG A 1 100 ? 10.840  7.111   1.973   1.00 28.07 ? 100  ARG A NH1 1 ? 
ATOM   788  N NH2 . ARG A 1 100 ? 11.062  5.595   3.670   1.00 32.77 ? 100  ARG A NH2 1 ? 
ATOM   789  N N   . VAL A 1 101 ? 6.111   3.145   -1.587  1.00 13.37 ? 101  VAL A N   1 ? 
ATOM   790  C CA  . VAL A 1 101 ? 6.523   2.094   -2.548  1.00 12.78 ? 101  VAL A CA  1 ? 
ATOM   791  C C   . VAL A 1 101 ? 7.809   2.570   -3.202  1.00 13.39 ? 101  VAL A C   1 ? 
ATOM   792  O O   . VAL A 1 101 ? 7.847   3.721   -3.684  1.00 15.14 ? 101  VAL A O   1 ? 
ATOM   793  C CB  . VAL A 1 101 ? 5.419   1.788   -3.570  1.00 13.25 ? 101  VAL A CB  1 ? 
ATOM   794  C CG1 . VAL A 1 101 ? 5.917   0.824   -4.637  1.00 13.20 ? 101  VAL A CG1 1 ? 
ATOM   795  C CG2 . VAL A 1 101 ? 4.182   1.217   -2.912  1.00 13.33 ? 101  VAL A CG2 1 ? 
ATOM   796  N N   . LEU A 1 102 ? 8.810   1.706   -3.264  1.00 12.71 ? 102  LEU A N   1 ? 
ATOM   797  C CA  . LEU A 1 102 ? 10.030  1.970   -4.058  1.00 13.55 ? 102  LEU A CA  1 ? 
ATOM   798  C C   . LEU A 1 102 ? 9.851   1.180   -5.344  1.00 13.14 ? 102  LEU A C   1 ? 
ATOM   799  O O   . LEU A 1 102 ? 9.930   -0.061  -5.305  1.00 13.08 ? 102  LEU A O   1 ? 
ATOM   800  C CB  . LEU A 1 102 ? 11.303  1.573   -3.323  1.00 13.93 ? 102  LEU A CB  1 ? 
ATOM   801  C CG  . LEU A 1 102 ? 12.582  1.876   -4.107  1.00 15.02 ? 102  LEU A CG  1 ? 
ATOM   802  C CD1 . LEU A 1 102 ? 12.787  3.382   -4.296  1.00 15.81 ? 102  LEU A CD1 1 ? 
ATOM   803  C CD2 . LEU A 1 102 ? 13.801  1.271   -3.445  1.00 15.09 ? 102  LEU A CD2 1 ? 
ATOM   804  N N   . LEU A 1 103 ? 9.654   1.885   -6.453  1.00 13.24 ? 103  LEU A N   1 ? 
ATOM   805  C CA  . LEU A 1 103 ? 9.427   1.261   -7.770  1.00 13.32 ? 103  LEU A CA  1 ? 
ATOM   806  C C   . LEU A 1 103 ? 10.745  1.330   -8.523  1.00 13.48 ? 103  LEU A C   1 ? 
ATOM   807  O O   . LEU A 1 103 ? 11.169  2.460   -8.861  1.00 15.09 ? 103  LEU A O   1 ? 
ATOM   808  C CB  . LEU A 1 103 ? 8.294   2.011   -8.457  1.00 14.50 ? 103  LEU A CB  1 ? 
ATOM   809  C CG  . LEU A 1 103 ? 7.908   1.527   -9.842  1.00 15.49 ? 103  LEU A CG  1 ? 
ATOM   810  C CD1 . LEU A 1 103 ? 7.366   0.098   -9.801  1.00 16.35 ? 103  LEU A CD1 1 ? 
ATOM   811  C CD2 . LEU A 1 103 ? 6.891   2.485   -10.459 1.00 16.30 ? 103  LEU A CD2 1 ? 
ATOM   812  N N   . ILE A 1 104 ? 11.389  0.193   -8.765  1.00 12.51 ? 104  ILE A N   1 ? 
ATOM   813  C CA  . ILE A 1 104 ? 12.753  0.227   -9.336  1.00 12.28 ? 104  ILE A CA  1 ? 
ATOM   814  C C   . ILE A 1 104 ? 12.737  -0.058  -10.832 1.00 13.08 ? 104  ILE A C   1 ? 
ATOM   815  O O   . ILE A 1 104 ? 11.918  -0.850  -11.345 1.00 13.74 ? 104  ILE A O   1 ? 
ATOM   816  C CB  . ILE A 1 104 ? 13.739  -0.681  -8.593  1.00 12.95 ? 104  ILE A CB  1 ? 
ATOM   817  C CG1 . ILE A 1 104 ? 13.368  -2.160  -8.645  1.00 13.02 ? 104  ILE A CG1 1 ? 
ATOM   818  C CG2 . ILE A 1 104 ? 13.908  -0.186  -7.174  1.00 13.05 ? 104  ILE A CG2 1 ? 
ATOM   819  C CD1 . ILE A 1 104 ? 14.495  -3.055  -8.210  1.00 13.03 ? 104  ILE A CD1 1 ? 
ATOM   820  N N   . ASP A 1 105 ? 13.701  0.582   -11.494 1.00 13.55 ? 105  ASP A N   1 ? 
ATOM   821  C CA  . ASP A 1 105 ? 13.986  0.375   -12.928 1.00 14.20 ? 105  ASP A CA  1 ? 
ATOM   822  C C   . ASP A 1 105 ? 15.095  -0.668  -13.010 1.00 13.69 ? 105  ASP A C   1 ? 
ATOM   823  O O   . ASP A 1 105 ? 16.228  -0.311  -13.327 1.00 15.25 ? 105  ASP A O   1 ? 
ATOM   824  C CB  . ASP A 1 105 ? 14.339  1.707   -13.584 1.00 16.02 ? 105  ASP A CB  1 ? 
ATOM   825  C CG  . ASP A 1 105 ? 14.459  1.572   -15.084 1.00 18.61 ? 105  ASP A CG  1 ? 
ATOM   826  O OD1 . ASP A 1 105 ? 13.703  0.773   -15.642 1.00 21.44 ? 105  ASP A OD1 1 ? 
ATOM   827  O OD2 . ASP A 1 105 ? 15.328  2.238   -15.677 1.00 24.83 ? 105  ASP A OD2 1 ? 
ATOM   828  N N   . TYR A 1 106 ? 14.787  -1.924  -12.724 1.00 13.13 ? 106  TYR A N   1 ? 
ATOM   829  C CA  . TYR A 1 106 ? 15.803  -3.005  -12.816 1.00 12.20 ? 106  TYR A CA  1 ? 
ATOM   830  C C   . TYR A 1 106 ? 16.191  -3.199  -14.290 1.00 12.10 ? 106  TYR A C   1 ? 
ATOM   831  O O   . TYR A 1 106 ? 15.417  -2.906  -15.246 1.00 12.75 ? 106  TYR A O   1 ? 
ATOM   832  C CB  . TYR A 1 106 ? 15.285  -4.276  -12.149 1.00 12.01 ? 106  TYR A CB  1 ? 
ATOM   833  C CG  . TYR A 1 106 ? 14.079  -4.916  -12.780 1.00 10.96 ? 106  TYR A CG  1 ? 
ATOM   834  C CD1 . TYR A 1 106 ? 14.200  -5.748  -13.876 1.00 10.39 ? 106  TYR A CD1 1 ? 
ATOM   835  C CD2 . TYR A 1 106 ? 12.811  -4.707  -12.275 1.00 11.15 ? 106  TYR A CD2 1 ? 
ATOM   836  C CE1 . TYR A 1 106 ? 13.104  -6.347  -14.456 1.00 10.93 ? 106  TYR A CE1 1 ? 
ATOM   837  C CE2 . TYR A 1 106 ? 11.700  -5.299  -12.842 1.00 10.40 ? 106  TYR A CE2 1 ? 
ATOM   838  C CZ  . TYR A 1 106 ? 11.842  -6.132  -13.929 1.00 9.97  ? 106  TYR A CZ  1 ? 
ATOM   839  O OH  . TYR A 1 106 ? 10.761  -6.747  -14.517 1.00 11.12 ? 106  TYR A OH  1 ? 
ATOM   840  N N   . ARG A 1 107 ? 17.405  -3.699  -14.492 1.00 11.78 ? 107  ARG A N   1 ? 
ATOM   841  C CA  . ARG A 1 107 ? 17.951  -3.869  -15.856 1.00 12.93 ? 107  ARG A CA  1 ? 
ATOM   842  C C   . ARG A 1 107 ? 17.094  -4.858  -16.640 1.00 12.08 ? 107  ARG A C   1 ? 
ATOM   843  O O   . ARG A 1 107 ? 16.772  -5.928  -16.086 1.00 12.09 ? 107  ARG A O   1 ? 
ATOM   844  C CB  . ARG A 1 107 ? 19.414  -4.294  -15.781 1.00 13.44 ? 107  ARG A CB  1 ? 
ATOM   845  C CG  . ARG A 1 107 ? 20.353  -3.116  -15.614 1.00 14.92 ? 107  ARG A CG  1 ? 
ATOM   846  C CD  . ARG A 1 107 ? 21.773  -3.566  -15.358 1.00 14.76 ? 107  ARG A CD  1 ? 
ATOM   847  N NE  . ARG A 1 107 ? 21.902  -4.262  -14.085 1.00 15.57 ? 107  ARG A NE  1 ? 
ATOM   848  C CZ  . ARG A 1 107 ? 22.888  -5.085  -13.753 1.00 18.00 ? 107  ARG A CZ  1 ? 
ATOM   849  N NH1 . ARG A 1 107 ? 23.886  -5.328  -14.595 1.00 19.45 ? 107  ARG A NH1 1 ? 
ATOM   850  N NH2 . ARG A 1 107 ? 22.885  -5.684  -12.577 1.00 18.09 ? 107  ARG A NH2 1 ? 
ATOM   851  N N   . LEU A 1 108 ? 16.808  -4.525  -17.897 1.00 12.04 ? 108  LEU A N   1 ? 
ATOM   852  C CA  . LEU A 1 108 ? 15.929  -5.343  -18.771 1.00 11.49 ? 108  LEU A CA  1 ? 
ATOM   853  C C   . LEU A 1 108 ? 16.738  -6.062  -19.852 1.00 11.99 ? 108  LEU A C   1 ? 
ATOM   854  O O   . LEU A 1 108 ? 17.769  -5.553  -20.324 1.00 12.12 ? 108  LEU A O   1 ? 
ATOM   855  C CB  . LEU A 1 108 ? 14.849  -4.464  -19.406 1.00 11.54 ? 108  LEU A CB  1 ? 
ATOM   856  C CG  . LEU A 1 108 ? 13.858  -3.819  -18.436 1.00 12.51 ? 108  LEU A CG  1 ? 
ATOM   857  C CD1 . LEU A 1 108 ? 13.002  -2.818  -19.153 1.00 13.39 ? 108  LEU A CD1 1 ? 
ATOM   858  C CD2 . LEU A 1 108 ? 12.980  -4.848  -17.730 1.00 12.82 ? 108  LEU A CD2 1 ? 
ATOM   859  N N   . ALA A 1 109 ? 16.253  -7.230  -20.214 1.00 10.82 ? 109  ALA A N   1 ? 
ATOM   860  C CA  . ALA A 1 109 ? 16.700  -8.010  -21.380 1.00 11.23 ? 109  ALA A CA  1 ? 
ATOM   861  C C   . ALA A 1 109 ? 16.028  -7.466  -22.631 1.00 11.21 ? 109  ALA A C   1 ? 
ATOM   862  O O   . ALA A 1 109 ? 14.973  -6.798  -22.545 1.00 10.37 ? 109  ALA A O   1 ? 
ATOM   863  C CB  . ALA A 1 109 ? 16.347  -9.446  -21.155 1.00 11.39 ? 109  ALA A CB  1 ? 
ATOM   864  N N   . PRO A 1 110 ? 16.540  -7.725  -23.861 1.00 11.55 ? 110  PRO A N   1 ? 
ATOM   865  C CA  . PRO A 1 110 ? 17.770  -8.475  -24.121 1.00 11.61 ? 110  PRO A CA  1 ? 
ATOM   866  C C   . PRO A 1 110 ? 19.097  -7.772  -23.823 1.00 11.62 ? 110  PRO A C   1 ? 
ATOM   867  O O   . PRO A 1 110 ? 20.111  -8.448  -23.796 1.00 13.63 ? 110  PRO A O   1 ? 
ATOM   868  C CB  . PRO A 1 110 ? 17.690  -8.702  -25.632 1.00 11.89 ? 110  PRO A CB  1 ? 
ATOM   869  C CG  . PRO A 1 110 ? 16.990  -7.452  -26.125 1.00 12.40 ? 110  PRO A CG  1 ? 
ATOM   870  C CD  . PRO A 1 110 ? 15.908  -7.240  -25.093 1.00 12.20 ? 110  PRO A CD  1 ? 
ATOM   871  N N   . GLU A 1 111 ? 19.071  -6.466  -23.565 1.00 11.34 ? 111  GLU A N   1 ? 
ATOM   872  C CA  . GLU A 1 111 ? 20.304  -5.684  -23.313 1.00 12.39 ? 111  GLU A CA  1 ? 
ATOM   873  C C   . GLU A 1 111 ? 21.044  -6.262  -22.115 1.00 13.69 ? 111  GLU A C   1 ? 
ATOM   874  O O   . GLU A 1 111 ? 22.291  -6.351  -22.159 1.00 14.30 ? 111  GLU A O   1 ? 
ATOM   875  C CB  . GLU A 1 111 ? 19.958  -4.214  -23.062 1.00 14.10 ? 111  GLU A CB  1 ? 
ATOM   876  C CG  . GLU A 1 111 ? 19.355  -3.538  -24.270 1.00 15.33 ? 111  GLU A CG  1 ? 
ATOM   877  C CD  . GLU A 1 111 ? 17.852  -3.597  -24.464 1.00 16.84 ? 111  GLU A CD  1 ? 
ATOM   878  O OE1 . GLU A 1 111 ? 17.343  -2.807  -25.270 1.00 16.46 ? 111  GLU A OE1 1 ? 
ATOM   879  O OE2 . GLU A 1 111 ? 17.200  -4.467  -23.846 1.00 15.38 ? 111  GLU A OE2 1 ? 
ATOM   880  N N   . HIS A 1 112 ? 20.317  -6.601  -21.052 1.00 12.64 ? 112  HIS A N   1 ? 
ATOM   881  C CA  . HIS A 1 112 ? 20.885  -7.068  -19.767 1.00 13.70 ? 112  HIS A CA  1 ? 
ATOM   882  C C   . HIS A 1 112 ? 20.219  -8.376  -19.368 1.00 13.74 ? 112  HIS A C   1 ? 
ATOM   883  O O   . HIS A 1 112 ? 19.174  -8.375  -18.706 1.00 13.37 ? 112  HIS A O   1 ? 
ATOM   884  C CB  . HIS A 1 112 ? 20.714  -6.019  -18.684 1.00 13.95 ? 112  HIS A CB  1 ? 
ATOM   885  C CG  . HIS A 1 112 ? 21.241  -4.689  -19.077 1.00 15.00 ? 112  HIS A CG  1 ? 
ATOM   886  N ND1 . HIS A 1 112 ? 22.595  -4.454  -19.229 1.00 17.59 ? 112  HIS A ND1 1 ? 
ATOM   887  C CD2 . HIS A 1 112 ? 20.609  -3.524  -19.317 1.00 16.23 ? 112  HIS A CD2 1 ? 
ATOM   888  C CE1 . HIS A 1 112 ? 22.765  -3.190  -19.574 1.00 18.95 ? 112  HIS A CE1 1 ? 
ATOM   889  N NE2 . HIS A 1 112 ? 21.570  -2.582  -19.582 1.00 17.74 ? 112  HIS A NE2 1 ? 
ATOM   890  N N   . PRO A 1 113 ? 20.784  -9.513  -19.788 1.00 12.97 ? 113  PRO A N   1 ? 
ATOM   891  C CA  . PRO A 1 113 ? 20.219  -10.815 -19.462 1.00 12.91 ? 113  PRO A CA  1 ? 
ATOM   892  C C   . PRO A 1 113 ? 20.283  -11.147 -17.965 1.00 12.02 ? 113  PRO A C   1 ? 
ATOM   893  O O   . PRO A 1 113 ? 21.013  -10.526 -17.204 1.00 12.33 ? 113  PRO A O   1 ? 
ATOM   894  C CB  . PRO A 1 113 ? 21.063  -11.825 -20.259 1.00 14.79 ? 113  PRO A CB  1 ? 
ATOM   895  C CG  . PRO A 1 113 ? 21.788  -10.988 -21.285 1.00 15.81 ? 113  PRO A CG  1 ? 
ATOM   896  C CD  . PRO A 1 113 ? 21.948  -9.620  -20.676 1.00 15.40 ? 113  PRO A CD  1 ? 
ATOM   897  N N   . HIS A 1 114 ? 19.537  -12.176 -17.598 1.00 11.68 ? 114  HIS A N   1 ? 
ATOM   898  C CA  . HIS A 1 114 ? 19.652  -12.834 -16.285 1.00 11.68 ? 114  HIS A CA  1 ? 
ATOM   899  C C   . HIS A 1 114 ? 21.145  -13.034 -16.028 1.00 11.73 ? 114  HIS A C   1 ? 
ATOM   900  O O   . HIS A 1 114 ? 21.857  -13.529 -16.914 1.00 13.22 ? 114  HIS A O   1 ? 
ATOM   901  C CB  . HIS A 1 114 ? 18.886  -14.158 -16.285 1.00 12.16 ? 114  HIS A CB  1 ? 
ATOM   902  C CG  . HIS A 1 114 ? 19.010  -14.844 -14.972 1.00 13.54 ? 114  HIS A CG  1 ? 
ATOM   903  N ND1 . HIS A 1 114 ? 18.248  -14.463 -13.896 1.00 13.45 ? 114  HIS A ND1 1 ? 
ATOM   904  C CD2 . HIS A 1 114 ? 19.889  -15.778 -14.529 1.00 13.82 ? 114  HIS A CD2 1 ? 
ATOM   905  C CE1 . HIS A 1 114 ? 18.609  -15.188 -12.839 1.00 13.55 ? 114  HIS A CE1 1 ? 
ATOM   906  N NE2 . HIS A 1 114 ? 19.623  -15.998 -13.208 1.00 14.10 ? 114  HIS A NE2 1 ? 
ATOM   907  N N   . PRO A 1 115 ? 21.693  -12.741 -14.824 1.00 12.12 ? 115  PRO A N   1 ? 
ATOM   908  C CA  . PRO A 1 115 ? 20.948  -12.350 -13.622 1.00 12.37 ? 115  PRO A CA  1 ? 
ATOM   909  C C   . PRO A 1 115 ? 20.832  -10.855 -13.293 1.00 12.21 ? 115  PRO A C   1 ? 
ATOM   910  O O   . PRO A 1 115 ? 20.636  -10.503 -12.137 1.00 12.80 ? 115  PRO A O   1 ? 
ATOM   911  C CB  . PRO A 1 115 ? 21.804  -13.051 -12.560 1.00 12.99 ? 115  PRO A CB  1 ? 
ATOM   912  C CG  . PRO A 1 115 ? 23.201  -12.804 -13.033 1.00 13.60 ? 115  PRO A CG  1 ? 
ATOM   913  C CD  . PRO A 1 115 ? 23.098  -13.046 -14.520 1.00 13.13 ? 115  PRO A CD  1 ? 
ATOM   914  N N   . ALA A 1 116 ? 20.961  -9.971  -14.278 1.00 11.99 ? 116  ALA A N   1 ? 
ATOM   915  C CA  . ALA A 1 116 ? 20.978  -8.520  -14.028 1.00 11.83 ? 116  ALA A CA  1 ? 
ATOM   916  C C   . ALA A 1 116 ? 19.754  -8.093  -13.199 1.00 10.97 ? 116  ALA A C   1 ? 
ATOM   917  O O   . ALA A 1 116 ? 19.921  -7.304  -12.259 1.00 11.92 ? 116  ALA A O   1 ? 
ATOM   918  C CB  . ALA A 1 116 ? 21.084  -7.779  -15.341 1.00 12.20 ? 116  ALA A CB  1 ? 
ATOM   919  N N   . ALA A 1 117 ? 18.555  -8.554  -13.544 1.00 10.99 ? 117  ALA A N   1 ? 
ATOM   920  C CA  . ALA A 1 117 ? 17.333  -8.110  -12.830 1.00 11.23 ? 117  ALA A CA  1 ? 
ATOM   921  C C   . ALA A 1 117 ? 17.441  -8.438  -11.335 1.00 11.13 ? 117  ALA A C   1 ? 
ATOM   922  O O   . ALA A 1 117 ? 17.032  -7.609  -10.506 1.00 11.37 ? 117  ALA A O   1 ? 
ATOM   923  C CB  . ALA A 1 117 ? 16.116  -8.760  -13.412 1.00 11.15 ? 117  ALA A CB  1 ? 
ATOM   924  N N   A VAL A 1 118 ? 17.931  -9.643  -11.005 0.50 11.21 ? 118  VAL A N   1 ? 
ATOM   925  N N   B VAL A 1 118 ? 17.930  -9.639  -11.003 0.50 12.15 ? 118  VAL A N   1 ? 
ATOM   926  C CA  A VAL A 1 118 ? 18.013  -10.136 -9.595  0.50 11.17 ? 118  VAL A CA  1 ? 
ATOM   927  C CA  B VAL A 1 118 ? 17.983  -10.123 -9.591  0.50 12.71 ? 118  VAL A CA  1 ? 
ATOM   928  C C   A VAL A 1 118 ? 19.137  -9.404  -8.871  0.50 11.78 ? 118  VAL A C   1 ? 
ATOM   929  C C   B VAL A 1 118 ? 19.139  -9.425  -8.867  0.50 12.71 ? 118  VAL A C   1 ? 
ATOM   930  O O   A VAL A 1 118 ? 18.994  -9.112  -7.668  0.50 12.11 ? 118  VAL A O   1 ? 
ATOM   931  O O   B VAL A 1 118 ? 18.995  -9.119  -7.668  0.50 13.03 ? 118  VAL A O   1 ? 
ATOM   932  C CB  A VAL A 1 118 ? 18.244  -11.655 -9.488  0.50 11.30 ? 118  VAL A CB  1 ? 
ATOM   933  C CB  B VAL A 1 118 ? 18.051  -11.663 -9.502  0.50 14.17 ? 118  VAL A CB  1 ? 
ATOM   934  C CG1 A VAL A 1 118 ? 17.974  -12.087 -8.043  0.50 10.79 ? 118  VAL A CG1 1 ? 
ATOM   935  C CG1 B VAL A 1 118 ? 16.882  -12.342 -10.185 0.50 15.09 ? 118  VAL A CG1 1 ? 
ATOM   936  C CG2 A VAL A 1 118 ? 17.408  -12.446 -10.475 0.50 11.53 ? 118  VAL A CG2 1 ? 
ATOM   937  C CG2 B VAL A 1 118 ? 19.340  -12.235 -10.015 0.50 14.62 ? 118  VAL A CG2 1 ? 
ATOM   938  N N   . GLU A 1 119 ? 20.240  -9.132  -9.559  1.00 12.32 ? 119  GLU A N   1 ? 
ATOM   939  C CA  . GLU A 1 119 ? 21.322  -8.306  -8.978  1.00 13.54 ? 119  GLU A CA  1 ? 
ATOM   940  C C   . GLU A 1 119 ? 20.731  -6.959  -8.569  1.00 12.33 ? 119  GLU A C   1 ? 
ATOM   941  O O   . GLU A 1 119 ? 21.024  -6.461  -7.473  1.00 12.95 ? 119  GLU A O   1 ? 
ATOM   942  C CB  . GLU A 1 119 ? 22.450  -8.116  -9.989  1.00 15.33 ? 119  GLU A CB  1 ? 
ATOM   943  C CG  . GLU A 1 119 ? 23.218  -9.392  -10.253 1.00 18.31 ? 119  GLU A CG  1 ? 
ATOM   944  C CD  . GLU A 1 119 ? 24.314  -9.253  -11.296 1.00 24.25 ? 119  GLU A CD  1 ? 
ATOM   945  O OE1 . GLU A 1 119 ? 25.159  -10.167 -11.385 1.00 27.67 ? 119  GLU A OE1 1 ? 
ATOM   946  O OE2 . GLU A 1 119 ? 24.323  -8.232  -12.019 1.00 28.34 ? 119  GLU A OE2 1 ? 
ATOM   947  N N   . ASP A 1 120 ? 19.896  -6.364  -9.418  1.00 11.55 ? 120  ASP A N   1 ? 
ATOM   948  C CA  . ASP A 1 120 ? 19.330  -5.020  -9.143  1.00 12.22 ? 120  ASP A CA  1 ? 
ATOM   949  C C   . ASP A 1 120 ? 18.284  -5.083  -8.018  1.00 11.69 ? 120  ASP A C   1 ? 
ATOM   950  O O   . ASP A 1 120 ? 18.267  -4.180  -7.180  1.00 11.55 ? 120  ASP A O   1 ? 
ATOM   951  C CB  . ASP A 1 120 ? 18.738  -4.404  -10.413 1.00 12.03 ? 120  ASP A CB  1 ? 
ATOM   952  C CG  . ASP A 1 120 ? 19.794  -3.933  -11.397 1.00 14.65 ? 120  ASP A CG  1 ? 
ATOM   953  O OD1 . ASP A 1 120 ? 20.985  -3.939  -11.035 1.00 16.88 ? 120  ASP A OD1 1 ? 
ATOM   954  O OD2 . ASP A 1 120 ? 19.416  -3.581  -12.503 1.00 15.48 ? 120  ASP A OD2 1 ? 
ATOM   955  N N   . SER A 1 121 ? 17.371  -6.044  -8.026  1.00 11.24 ? 121  SER A N   1 ? 
ATOM   956  C CA  . SER A 1 121 ? 16.335  -6.120  -6.968  1.00 11.03 ? 121  SER A CA  1 ? 
ATOM   957  C C   . SER A 1 121 ? 16.984  -6.359  -5.604  1.00 11.32 ? 121  SER A C   1 ? 
ATOM   958  O O   . SER A 1 121 ? 16.572  -5.721  -4.619  1.00 11.21 ? 121  SER A O   1 ? 
ATOM   959  C CB  . SER A 1 121 ? 15.310  -7.162  -7.298  1.00 12.06 ? 121  SER A CB  1 ? 
ATOM   960  O OG  . SER A 1 121 ? 15.914  -8.432  -7.462  1.00 13.90 ? 121  SER A OG  1 ? 
ATOM   961  N N   . THR A 1 122 ? 17.979  -7.237  -5.529  1.00 11.13 ? 122  THR A N   1 ? 
ATOM   962  C CA  . THR A 1 122 ? 18.670  -7.502  -4.249  1.00 13.04 ? 122  THR A CA  1 ? 
ATOM   963  C C   . THR A 1 122 ? 19.454  -6.255  -3.827  1.00 13.25 ? 122  THR A C   1 ? 
ATOM   964  O O   . THR A 1 122 ? 19.400  -5.903  -2.634  1.00 13.76 ? 122  THR A O   1 ? 
ATOM   965  C CB  . THR A 1 122 ? 19.547  -8.745  -4.299  1.00 13.49 ? 122  THR A CB  1 ? 
ATOM   966  O OG1 . THR A 1 122 ? 20.540  -8.573  -5.308  1.00 14.44 ? 122  THR A OG1 1 ? 
ATOM   967  C CG2 . THR A 1 122 ? 18.757  -10.004 -4.539  1.00 13.94 ? 122  THR A CG2 1 ? 
ATOM   968  N N   . ARG A 1 123 ? 20.077  -5.531  -4.764  1.00 13.50 ? 123  ARG A N   1 ? 
ATOM   969  C CA  . ARG A 1 123 ? 20.816  -4.288  -4.410  1.00 15.26 ? 123  ARG A CA  1 ? 
ATOM   970  C C   . ARG A 1 123 ? 19.855  -3.256  -3.827  1.00 14.18 ? 123  ARG A C   1 ? 
ATOM   971  O O   . ARG A 1 123 ? 20.208  -2.602  -2.837  1.00 14.15 ? 123  ARG A O   1 ? 
ATOM   972  C CB  . ARG A 1 123 ? 21.507  -3.715  -5.647  1.00 17.55 ? 123  ARG A CB  1 ? 
ATOM   973  C CG  . ARG A 1 123 ? 22.284  -2.439  -5.394  1.00 22.99 ? 123  ARG A CG  1 ? 
ATOM   974  C CD  . ARG A 1 123 ? 23.491  -2.673  -4.506  1.00 29.38 ? 123  ARG A CD  1 ? 
ATOM   975  N NE  . ARG A 1 123 ? 23.993  -1.449  -3.884  1.00 33.84 ? 123  ARG A NE  1 ? 
ATOM   976  C CZ  . ARG A 1 123 ? 23.702  -1.048  -2.646  1.00 37.25 ? 123  ARG A CZ  1 ? 
ATOM   977  N NH1 . ARG A 1 123 ? 22.915  -1.770  -1.862  1.00 35.16 ? 123  ARG A NH1 1 ? 
ATOM   978  N NH2 . ARG A 1 123 ? 24.234  0.071   -2.185  1.00 40.74 ? 123  ARG A NH2 1 ? 
ATOM   979  N N   . ALA A 1 124 ? 18.680  -3.075  -4.427  1.00 12.44 ? 124  ALA A N   1 ? 
ATOM   980  C CA  . ALA A 1 124 ? 17.705  -2.077  -3.977  1.00 13.07 ? 124  ALA A CA  1 ? 
ATOM   981  C C   . ALA A 1 124 ? 17.217  -2.448  -2.575  1.00 12.75 ? 124  ALA A C   1 ? 
ATOM   982  O O   . ALA A 1 124 ? 17.087  -1.563  -1.743  1.00 13.20 ? 124  ALA A O   1 ? 
ATOM   983  C CB  . ALA A 1 124 ? 16.550  -1.993  -4.944  1.00 13.29 ? 124  ALA A CB  1 ? 
ATOM   984  N N   . TYR A 1 125 ? 16.961  -3.720  -2.306  1.00 12.06 ? 125  TYR A N   1 ? 
ATOM   985  C CA  . TYR A 1 125 ? 16.504  -4.141  -0.955  1.00 12.46 ? 125  TYR A CA  1 ? 
ATOM   986  C C   . TYR A 1 125 ? 17.596  -3.837  0.073   1.00 13.07 ? 125  TYR A C   1 ? 
ATOM   987  O O   . TYR A 1 125 ? 17.272  -3.267  1.136   1.00 13.16 ? 125  TYR A O   1 ? 
ATOM   988  C CB  . TYR A 1 125 ? 16.177  -5.627  -0.958  1.00 11.96 ? 125  TYR A CB  1 ? 
ATOM   989  C CG  . TYR A 1 125 ? 15.606  -6.119  0.353   1.00 11.91 ? 125  TYR A CG  1 ? 
ATOM   990  C CD1 . TYR A 1 125 ? 16.432  -6.555  1.371   1.00 11.94 ? 125  TYR A CD1 1 ? 
ATOM   991  C CD2 . TYR A 1 125 ? 14.242  -6.187  0.553   1.00 12.41 ? 125  TYR A CD2 1 ? 
ATOM   992  C CE1 . TYR A 1 125 ? 15.908  -7.023  2.564   1.00 13.13 ? 125  TYR A CE1 1 ? 
ATOM   993  C CE2 . TYR A 1 125 ? 13.699  -6.675  1.734   1.00 13.65 ? 125  TYR A CE2 1 ? 
ATOM   994  C CZ  . TYR A 1 125 ? 14.537  -7.070  2.757   1.00 13.20 ? 125  TYR A CZ  1 ? 
ATOM   995  O OH  . TYR A 1 125 ? 14.033  -7.579  3.919   1.00 13.49 ? 125  TYR A OH  1 ? 
ATOM   996  N N   . ARG A 1 126 ? 18.840  -4.189  -0.244  1.00 14.12 ? 126  ARG A N   1 ? 
ATOM   997  C CA  . ARG A 1 126 ? 19.972  -3.935  0.689   1.00 15.73 ? 126  ARG A CA  1 ? 
ATOM   998  C C   . ARG A 1 126 ? 20.143  -2.427  0.880   1.00 15.65 ? 126  ARG A C   1 ? 
ATOM   999  O O   . ARG A 1 126 ? 20.468  -2.028  2.001   1.00 16.60 ? 126  ARG A O   1 ? 
ATOM   1000 C CB  . ARG A 1 126 ? 21.231  -4.628  0.179   1.00 17.69 ? 126  ARG A CB  1 ? 
ATOM   1001 C CG  . ARG A 1 126 ? 21.067  -6.134  0.184   1.00 21.91 ? 126  ARG A CG  1 ? 
ATOM   1002 C CD  . ARG A 1 126 ? 22.273  -6.853  -0.361  1.00 27.32 ? 126  ARG A CD  1 ? 
ATOM   1003 N NE  . ARG A 1 126 ? 23.216  -7.169  0.685   1.00 31.97 ? 126  ARG A NE  1 ? 
ATOM   1004 C CZ  . ARG A 1 126 ? 24.045  -8.206  0.666   1.00 36.01 ? 126  ARG A CZ  1 ? 
ATOM   1005 N NH1 . ARG A 1 126 ? 24.027  -9.069  -0.340  1.00 37.95 ? 126  ARG A NH1 1 ? 
ATOM   1006 N NH2 . ARG A 1 126 ? 24.881  -8.386  1.670   1.00 40.08 ? 126  ARG A NH2 1 ? 
ATOM   1007 N N   . TRP A 1 127 ? 19.952  -1.623  -0.168  1.00 14.15 ? 127  TRP A N   1 ? 
ATOM   1008 C CA  . TRP A 1 127 ? 19.996  -0.147  -0.063  1.00 15.58 ? 127  TRP A CA  1 ? 
ATOM   1009 C C   . TRP A 1 127 ? 18.916  0.343   0.901   1.00 15.68 ? 127  TRP A C   1 ? 
ATOM   1010 O O   . TRP A 1 127 ? 19.202  1.250   1.716   1.00 16.65 ? 127  TRP A O   1 ? 
ATOM   1011 C CB  . TRP A 1 127 ? 19.859  0.493   -1.446  1.00 15.75 ? 127  TRP A CB  1 ? 
ATOM   1012 C CG  . TRP A 1 127 ? 19.815  1.986   -1.401  1.00 18.11 ? 127  TRP A CG  1 ? 
ATOM   1013 C CD1 . TRP A 1 127 ? 20.879  2.828   -1.276  1.00 19.21 ? 127  TRP A CD1 1 ? 
ATOM   1014 C CD2 . TRP A 1 127 ? 18.642  2.811   -1.454  1.00 17.28 ? 127  TRP A CD2 1 ? 
ATOM   1015 N NE1 . TRP A 1 127 ? 20.449  4.120   -1.280  1.00 17.37 ? 127  TRP A NE1 1 ? 
ATOM   1016 C CE2 . TRP A 1 127 ? 19.082  4.151   -1.374  1.00 18.06 ? 127  TRP A CE2 1 ? 
ATOM   1017 C CE3 . TRP A 1 127 ? 17.267  2.563   -1.579  1.00 16.95 ? 127  TRP A CE3 1 ? 
ATOM   1018 C CZ2 . TRP A 1 127 ? 18.189  5.218   -1.402  1.00 19.06 ? 127  TRP A CZ2 1 ? 
ATOM   1019 C CZ3 . TRP A 1 127 ? 16.389  3.618   -1.594  1.00 18.39 ? 127  TRP A CZ3 1 ? 
ATOM   1020 C CH2 . TRP A 1 127 ? 16.846  4.937   -1.511  1.00 19.12 ? 127  TRP A CH2 1 ? 
ATOM   1021 N N   . LEU A 1 128 ? 17.701  -0.195  0.824   1.00 14.85 ? 128  LEU A N   1 ? 
ATOM   1022 C CA  . LEU A 1 128 ? 16.623  0.192   1.762   1.00 15.02 ? 128  LEU A CA  1 ? 
ATOM   1023 C C   . LEU A 1 128 ? 17.099  -0.074  3.194   1.00 16.01 ? 128  LEU A C   1 ? 
ATOM   1024 O O   . LEU A 1 128 ? 16.869  0.793   4.051   1.00 16.11 ? 128  LEU A O   1 ? 
ATOM   1025 C CB  . LEU A 1 128 ? 15.340  -0.577  1.452   1.00 14.55 ? 128  LEU A CB  1 ? 
ATOM   1026 C CG  . LEU A 1 128 ? 14.561  -0.095  0.230   1.00 14.90 ? 128  LEU A CG  1 ? 
ATOM   1027 C CD1 . LEU A 1 128 ? 13.495  -1.099  -0.153  1.00 15.03 ? 128  LEU A CD1 1 ? 
ATOM   1028 C CD2 . LEU A 1 128 ? 13.943  1.265   0.483   1.00 15.67 ? 128  LEU A CD2 1 ? 
ATOM   1029 N N   . LEU A 1 129 ? 17.708  -1.227  3.453   1.00 15.92 ? 129  LEU A N   1 ? 
ATOM   1030 C CA  . LEU A 1 129 ? 18.225  -1.557  4.817   1.00 16.91 ? 129  LEU A CA  1 ? 
ATOM   1031 C C   . LEU A 1 129 ? 19.304  -0.546  5.196   1.00 19.06 ? 129  LEU A C   1 ? 
ATOM   1032 O O   . LEU A 1 129 ? 19.260  -0.053  6.348   1.00 19.53 ? 129  LEU A O   1 ? 
ATOM   1033 C CB  . LEU A 1 129 ? 18.821  -2.963  4.868   1.00 17.55 ? 129  LEU A CB  1 ? 
ATOM   1034 C CG  . LEU A 1 129 ? 17.859  -4.109  4.595   1.00 19.34 ? 129  LEU A CG  1 ? 
ATOM   1035 C CD1 . LEU A 1 129 ? 18.583  -5.440  4.695   1.00 18.47 ? 129  LEU A CD1 1 ? 
ATOM   1036 C CD2 . LEU A 1 129 ? 16.696  -4.069  5.551   1.00 20.81 ? 129  LEU A CD2 1 ? 
ATOM   1037 N N   . GLU A 1 130 ? 20.235  -0.272  4.283   1.00 20.64 ? 130  GLU A N   1 ? 
ATOM   1038 C CA  . GLU A 1 130 ? 21.389  0.635   4.535   1.00 23.79 ? 130  GLU A CA  1 ? 
ATOM   1039 C C   . GLU A 1 130 ? 20.874  2.022   4.913   1.00 24.28 ? 130  GLU A C   1 ? 
ATOM   1040 O O   . GLU A 1 130 ? 21.554  2.708   5.710   1.00 25.72 ? 130  GLU A O   1 ? 
ATOM   1041 C CB  . GLU A 1 130 ? 22.272  0.818   3.302   1.00 27.70 ? 130  GLU A CB  1 ? 
ATOM   1042 C CG  . GLU A 1 130 ? 23.113  -0.382  2.937   1.00 34.45 ? 130  GLU A CG  1 ? 
ATOM   1043 C CD  . GLU A 1 130 ? 23.755  -0.276  1.554   1.00 39.60 ? 130  GLU A CD  1 ? 
ATOM   1044 O OE1 . GLU A 1 130 ? 23.950  0.870   1.072   1.00 44.68 ? 130  GLU A OE1 1 ? 
ATOM   1045 O OE2 . GLU A 1 130 ? 24.022  -1.338  0.942   1.00 44.40 ? 130  GLU A OE2 1 ? 
ATOM   1046 N N   . THR A 1 131 ? 19.741  2.445   4.355   1.00 21.70 ? 131  THR A N   1 ? 
ATOM   1047 C CA  . THR A 1 131 ? 19.216  3.823   4.506   1.00 22.63 ? 131  THR A CA  1 ? 
ATOM   1048 C C   . THR A 1 131 ? 18.151  3.866   5.601   1.00 23.96 ? 131  THR A C   1 ? 
ATOM   1049 O O   . THR A 1 131 ? 17.532  4.930   5.747   1.00 26.09 ? 131  THR A O   1 ? 
ATOM   1050 C CB  . THR A 1 131 ? 18.768  4.392   3.159   1.00 21.96 ? 131  THR A CB  1 ? 
ATOM   1051 O OG1 . THR A 1 131 ? 17.802  3.546   2.534   1.00 20.76 ? 131  THR A OG1 1 ? 
ATOM   1052 C CG2 . THR A 1 131 ? 19.953  4.564   2.235   1.00 23.54 ? 131  THR A CG2 1 ? 
ATOM   1053 N N   . GLY A 1 132 ? 17.935  2.754   6.312   1.00 23.01 ? 132  GLY A N   1 ? 
ATOM   1054 C CA  . GLY A 1 132 ? 17.243  2.743   7.618   1.00 23.16 ? 132  GLY A CA  1 ? 
ATOM   1055 C C   . GLY A 1 132 ? 15.866  2.100   7.624   1.00 23.32 ? 132  GLY A C   1 ? 
ATOM   1056 O O   . GLY A 1 132 ? 15.181  2.194   8.662   1.00 22.91 ? 132  GLY A O   1 ? 
ATOM   1057 N N   . SER A 1 133 ? 15.419  1.475   6.533   1.00 19.69 ? 133  SER A N   1 ? 
ATOM   1058 C CA  . SER A 1 133 ? 14.158  0.698   6.541   1.00 19.35 ? 133  SER A CA  1 ? 
ATOM   1059 C C   . SER A 1 133 ? 14.398  -0.571  7.357   1.00 19.29 ? 133  SER A C   1 ? 
ATOM   1060 O O   . SER A 1 133 ? 15.511  -1.117  7.329   1.00 19.91 ? 133  SER A O   1 ? 
ATOM   1061 C CB  . SER A 1 133 ? 13.690  0.368   5.132   1.00 20.55 ? 133  SER A CB  1 ? 
ATOM   1062 O OG  . SER A 1 133 ? 13.314  1.553   4.442   1.00 22.02 ? 133  SER A OG  1 ? 
ATOM   1063 N N   A ASP A 1 134 ? 13.369  -1.045  8.047   0.50 17.26 ? 134  ASP A N   1 ? 
ATOM   1064 N N   B ASP A 1 134 ? 13.379  -1.033  8.077   0.50 18.75 ? 134  ASP A N   1 ? 
ATOM   1065 C CA  A ASP A 1 134 ? 13.442  -2.264  8.885   0.50 16.81 ? 134  ASP A CA  1 ? 
ATOM   1066 C CA  B ASP A 1 134 ? 13.461  -2.262  8.904   0.50 19.17 ? 134  ASP A CA  1 ? 
ATOM   1067 C C   A ASP A 1 134 ? 12.642  -3.380  8.229   0.50 16.06 ? 134  ASP A C   1 ? 
ATOM   1068 C C   B ASP A 1 134 ? 12.649  -3.375  8.244   0.50 17.40 ? 134  ASP A C   1 ? 
ATOM   1069 O O   A ASP A 1 134 ? 11.488  -3.175  7.862   0.50 15.29 ? 134  ASP A O   1 ? 
ATOM   1070 O O   B ASP A 1 134 ? 11.493  -3.167  7.883   0.50 16.49 ? 134  ASP A O   1 ? 
ATOM   1071 C CB  A ASP A 1 134 ? 12.924  -1.976  10.291  0.50 17.32 ? 134  ASP A CB  1 ? 
ATOM   1072 C CB  B ASP A 1 134 ? 12.980  -2.023  10.338  0.50 21.70 ? 134  ASP A CB  1 ? 
ATOM   1073 C CG  A ASP A 1 134 ? 13.777  -0.913  10.946  0.50 18.17 ? 134  ASP A CG  1 ? 
ATOM   1074 C CG  B ASP A 1 134 ? 13.287  -3.206  11.241  0.50 24.63 ? 134  ASP A CG  1 ? 
ATOM   1075 O OD1 A ASP A 1 134 ? 15.008  -0.967  10.754  0.50 17.60 ? 134  ASP A OD1 1 ? 
ATOM   1076 O OD1 B ASP A 1 134 ? 12.593  -4.230  11.100  0.50 27.60 ? 134  ASP A OD1 1 ? 
ATOM   1077 O OD2 A ASP A 1 134 ? 13.200  -0.026  11.603  0.50 18.46 ? 134  ASP A OD2 1 ? 
ATOM   1078 O OD2 B ASP A 1 134 ? 14.259  -3.123  12.043  0.50 27.92 ? 134  ASP A OD2 1 ? 
ATOM   1079 N N   . PRO A 1 135 ? 13.217  -4.594  8.090   1.00 17.21 ? 135  PRO A N   1 ? 
ATOM   1080 C CA  . PRO A 1 135 ? 12.507  -5.710  7.461   1.00 15.89 ? 135  PRO A CA  1 ? 
ATOM   1081 C C   . PRO A 1 135 ? 11.096  -5.978  8.002   1.00 15.31 ? 135  PRO A C   1 ? 
ATOM   1082 O O   . PRO A 1 135 ? 10.221  -6.378  7.248   1.00 14.41 ? 135  PRO A O   1 ? 
ATOM   1083 C CB  . PRO A 1 135 ? 13.441  -6.901  7.731   1.00 17.61 ? 135  PRO A CB  1 ? 
ATOM   1084 C CG  . PRO A 1 135 ? 14.801  -6.278  7.770   1.00 18.84 ? 135  PRO A CG  1 ? 
ATOM   1085 C CD  . PRO A 1 135 ? 14.599  -4.939  8.446   1.00 18.62 ? 135  PRO A CD  1 ? 
ATOM   1086 N N   . LYS A 1 136 ? 10.863  -5.750  9.300   1.00 14.61 ? 136  LYS A N   1 ? 
ATOM   1087 C CA  . LYS A 1 136 ? 9.534   -6.047  9.883   1.00 16.03 ? 136  LYS A CA  1 ? 
ATOM   1088 C C   . LYS A 1 136 ? 8.487   -5.064  9.348   1.00 15.19 ? 136  LYS A C   1 ? 
ATOM   1089 O O   . LYS A 1 136 ? 7.303   -5.303  9.574   1.00 15.24 ? 136  LYS A O   1 ? 
ATOM   1090 C CB  . LYS A 1 136 ? 9.614   -6.030  11.411  1.00 18.77 ? 136  LYS A CB  1 ? 
ATOM   1091 C CG  . LYS A 1 136 ? 9.746   -4.656  12.035  1.00 22.68 ? 136  LYS A CG  1 ? 
ATOM   1092 C CD  . LYS A 1 136 ? 9.731   -4.683  13.568  1.00 27.69 ? 136  LYS A CD  1 ? 
ATOM   1093 C CE  . LYS A 1 136 ? 11.119  -4.590  14.159  1.00 32.19 ? 136  LYS A CE  1 ? 
ATOM   1094 N NZ  . LYS A 1 136 ? 11.111  -4.910  15.604  1.00 36.78 ? 136  LYS A NZ  1 ? 
ATOM   1095 N N   . ARG A 1 137 ? 8.925   -3.982  8.692   1.00 14.05 ? 137  ARG A N   1 ? 
ATOM   1096 C CA  . ARG A 1 137 ? 8.010   -2.969  8.113   1.00 14.37 ? 137  ARG A CA  1 ? 
ATOM   1097 C C   . ARG A 1 137 ? 8.172   -2.913  6.591   1.00 14.51 ? 137  ARG A C   1 ? 
ATOM   1098 O O   . ARG A 1 137 ? 7.786   -1.905  5.972   1.00 14.63 ? 137  ARG A O   1 ? 
ATOM   1099 C CB  . ARG A 1 137 ? 8.291   -1.605  8.750   1.00 16.08 ? 137  ARG A CB  1 ? 
ATOM   1100 C CG  . ARG A 1 137 ? 7.730   -1.480  10.156  1.00 18.61 ? 137  ARG A CG  1 ? 
ATOM   1101 C CD  . ARG A 1 137 ? 8.089   -0.109  10.702  1.00 19.34 ? 137  ARG A CD  1 ? 
ATOM   1102 N NE  . ARG A 1 137 ? 9.438   -0.119  11.217  1.00 22.13 ? 137  ARG A NE  1 ? 
ATOM   1103 C CZ  . ARG A 1 137 ? 9.774   -0.591  12.421  1.00 23.96 ? 137  ARG A CZ  1 ? 
ATOM   1104 N NH1 . ARG A 1 137 ? 8.843   -1.042  13.244  1.00 23.37 ? 137  ARG A NH1 1 ? 
ATOM   1105 N NH2 . ARG A 1 137 ? 11.034  -0.590  12.812  1.00 25.92 ? 137  ARG A NH2 1 ? 
ATOM   1106 N N   A MET A 1 138 ? 8.712   -3.973  5.997   0.50 12.45 ? 138  MET A N   1 ? 
ATOM   1107 N N   B MET A 1 138 ? 8.682   -3.985  5.997   0.50 14.75 ? 138  MET A N   1 ? 
ATOM   1108 C CA  A MET A 1 138 ? 8.978   -4.038  4.535   0.50 11.58 ? 138  MET A CA  1 ? 
ATOM   1109 C CA  B MET A 1 138 ? 8.929   -4.039  4.536   0.50 15.24 ? 138  MET A CA  1 ? 
ATOM   1110 C C   A MET A 1 138 ? 8.202   -5.208  3.917   0.50 11.45 ? 138  MET A C   1 ? 
ATOM   1111 C C   B MET A 1 138 ? 8.189   -5.219  3.915   0.50 13.41 ? 138  MET A C   1 ? 
ATOM   1112 O O   A MET A 1 138 ? 7.800   -6.159  4.627   0.50 11.27 ? 138  MET A O   1 ? 
ATOM   1113 O O   B MET A 1 138 ? 7.790   -6.169  4.622   0.50 12.92 ? 138  MET A O   1 ? 
ATOM   1114 C CB  A MET A 1 138 ? 10.474  -4.213  4.251   0.50 10.81 ? 138  MET A CB  1 ? 
ATOM   1115 C CB  B MET A 1 138 ? 10.425  -4.157  4.254   0.50 17.50 ? 138  MET A CB  1 ? 
ATOM   1116 C CG  A MET A 1 138 ? 11.325  -2.996  4.633   0.50 10.84 ? 138  MET A CG  1 ? 
ATOM   1117 C CG  B MET A 1 138 ? 11.158  -2.969  4.805   0.50 20.74 ? 138  MET A CG  1 ? 
ATOM   1118 S SD  A MET A 1 138 ? 13.092  -3.314  4.786   0.50 10.49 ? 138  MET A SD  1 ? 
ATOM   1119 S SD  B MET A 1 138 ? 12.673  -2.650  3.941   0.50 26.95 ? 138  MET A SD  1 ? 
ATOM   1120 C CE  A MET A 1 138 ? 13.551  -3.526  3.065   0.50 10.40 ? 138  MET A CE  1 ? 
ATOM   1121 C CE  B MET A 1 138 ? 13.706  -3.920  4.659   0.50 24.17 ? 138  MET A CE  1 ? 
ATOM   1122 N N   . ALA A 1 139 ? 8.046   -5.165  2.598   1.00 11.40 ? 139  ALA A N   1 ? 
ATOM   1123 C CA  . ALA A 1 139 ? 7.535   -6.286  1.802   1.00 11.26 ? 139  ALA A CA  1 ? 
ATOM   1124 C C   . ALA A 1 139 ? 8.134   -6.152  0.414   1.00 11.07 ? 139  ALA A C   1 ? 
ATOM   1125 O O   . ALA A 1 139 ? 8.600   -5.049  0.060   1.00 11.30 ? 139  ALA A O   1 ? 
ATOM   1126 C CB  . ALA A 1 139 ? 6.037   -6.267  1.747   1.00 12.06 ? 139  ALA A CB  1 ? 
ATOM   1127 N N   . ILE A 1 140 ? 8.113   -7.244  -0.335  1.00 10.34 ? 140  ILE A N   1 ? 
ATOM   1128 C CA  . ILE A 1 140 ? 8.496   -7.220  -1.772  1.00 10.43 ? 140  ILE A CA  1 ? 
ATOM   1129 C C   . ILE A 1 140 ? 7.262   -7.647  -2.542  1.00 10.72 ? 140  ILE A C   1 ? 
ATOM   1130 O O   . ILE A 1 140 ? 6.595   -8.603  -2.123  1.00 11.36 ? 140  ILE A O   1 ? 
ATOM   1131 C CB  . ILE A 1 140 ? 9.702   -8.114  -2.102  1.00 11.07 ? 140  ILE A CB  1 ? 
ATOM   1132 C CG1 . ILE A 1 140 ? 10.892  -7.777  -1.202  1.00 11.41 ? 140  ILE A CG1 1 ? 
ATOM   1133 C CG2 . ILE A 1 140 ? 10.087  -7.949  -3.570  1.00 11.51 ? 140  ILE A CG2 1 ? 
ATOM   1134 C CD1 . ILE A 1 140 ? 12.105  -8.651  -1.388  1.00 11.87 ? 140  ILE A CD1 1 ? 
ATOM   1135 N N   . ALA A 1 141 ? 6.931   -6.944  -3.616  1.00 10.99 ? 141  ALA A N   1 ? 
ATOM   1136 C CA  . ALA A 1 141 ? 5.748   -7.287  -4.421  1.00 10.41 ? 141  ALA A CA  1 ? 
ATOM   1137 C C   . ALA A 1 141 ? 6.083   -7.118  -5.900  1.00 10.07 ? 141  ALA A C   1 ? 
ATOM   1138 O O   . ALA A 1 141 ? 6.928   -6.286  -6.262  1.00 10.63 ? 141  ALA A O   1 ? 
ATOM   1139 C CB  . ALA A 1 141 ? 4.567   -6.429  -4.059  1.00 11.22 ? 141  ALA A CB  1 ? 
ATOM   1140 N N   . GLY A 1 142 ? 5.414   -7.883  -6.739  1.00 9.71  ? 142  GLY A N   1 ? 
ATOM   1141 C CA  . GLY A 1 142 ? 5.610   -7.718  -8.173  1.00 10.02 ? 142  GLY A CA  1 ? 
ATOM   1142 C C   . GLY A 1 142 ? 4.593   -8.467  -8.985  1.00 10.57 ? 142  GLY A C   1 ? 
ATOM   1143 O O   . GLY A 1 142 ? 4.011   -9.429  -8.480  1.00 10.75 ? 142  GLY A O   1 ? 
ATOM   1144 N N   . ASP A 1 143 ? 4.421   -8.049  -10.230 1.00 10.65 ? 143  ASP A N   1 ? 
ATOM   1145 C CA  . ASP A 1 143 ? 3.449   -8.665  -11.149 1.00 10.47 ? 143  ASP A CA  1 ? 
ATOM   1146 C C   . ASP A 1 143 ? 4.183   -9.426  -12.249 1.00 10.76 ? 143  ASP A C   1 ? 
ATOM   1147 O O   . ASP A 1 143 ? 5.197   -8.898  -12.774 1.00 11.24 ? 143  ASP A O   1 ? 
ATOM   1148 C CB  . ASP A 1 143 ? 2.512   -7.628  -11.767 1.00 10.85 ? 143  ASP A CB  1 ? 
ATOM   1149 C CG  . ASP A 1 143 ? 3.221   -6.525  -12.527 1.00 10.63 ? 143  ASP A CG  1 ? 
ATOM   1150 O OD1 . ASP A 1 143 ? 3.943   -5.733  -11.868 1.00 12.71 ? 143  ASP A OD1 1 ? 
ATOM   1151 O OD2 . ASP A 1 143 ? 3.118   -6.512  -13.784 1.00 11.97 ? 143  ASP A OD2 1 ? 
ATOM   1152 N N   . ALA A 1 144 ? 3.669   -10.602 -12.609 1.00 12.01 ? 144  ALA A N   1 ? 
ATOM   1153 C CA  . ALA A 1 144 ? 4.093   -11.311 -13.833 1.00 10.83 ? 144  ALA A CA  1 ? 
ATOM   1154 C C   . ALA A 1 144 ? 5.596   -11.624 -13.734 1.00 11.35 ? 144  ALA A C   1 ? 
ATOM   1155 O O   . ALA A 1 144 ? 5.985   -12.285 -12.784 1.00 10.93 ? 144  ALA A O   1 ? 
ATOM   1156 C CB  . ALA A 1 144 ? 3.707   -10.470 -15.029 1.00 12.49 ? 144  ALA A CB  1 ? 
ATOM   1157 N N   . ALA A 1 145 ? 6.449   -11.198 -14.673 1.00 10.32 ? 145  ALA A N   1 ? 
ATOM   1158 C CA  . ALA A 1 145 ? 7.912   -11.415 -14.511 1.00 10.51 ? 145  ALA A CA  1 ? 
ATOM   1159 C C   . ALA A 1 145 ? 8.382   -10.879 -13.157 1.00 10.72 ? 145  ALA A C   1 ? 
ATOM   1160 O O   . ALA A 1 145 ? 9.260   -11.480 -12.530 1.00 10.11 ? 145  ALA A O   1 ? 
ATOM   1161 C CB  . ALA A 1 145 ? 8.673   -10.759 -15.636 1.00 9.99  ? 145  ALA A CB  1 ? 
ATOM   1162 N N   . GLY A 1 146 ? 7.834   -9.749  -12.718 1.00 9.84  ? 146  GLY A N   1 ? 
ATOM   1163 C CA  . GLY A 1 146 ? 8.160   -9.138  -11.425 1.00 9.69  ? 146  GLY A CA  1 ? 
ATOM   1164 C C   . GLY A 1 146 ? 7.716   -10.005 -10.248 1.00 9.47  ? 146  GLY A C   1 ? 
ATOM   1165 O O   . GLY A 1 146 ? 8.312   -9.885  -9.162  1.00 9.89  ? 146  GLY A O   1 ? 
ATOM   1166 N N   . GLY A 1 147 ? 6.672   -10.814 -10.429 1.00 9.87  ? 147  GLY A N   1 ? 
ATOM   1167 C CA  . GLY A 1 147 ? 6.248   -11.783 -9.397  1.00 10.30 ? 147  GLY A CA  1 ? 
ATOM   1168 C C   . GLY A 1 147 ? 7.232   -12.925 -9.291  1.00 10.21 ? 147  GLY A C   1 ? 
ATOM   1169 O O   . GLY A 1 147 ? 7.572   -13.344 -8.173  1.00 11.01 ? 147  GLY A O   1 ? 
ATOM   1170 N N   . GLY A 1 148 ? 7.704   -13.435 -10.424 1.00 10.16 ? 148  GLY A N   1 ? 
ATOM   1171 C CA  . GLY A 1 148 ? 8.851   -14.356 -10.420 1.00 10.21 ? 148  GLY A CA  1 ? 
ATOM   1172 C C   . GLY A 1 148 ? 10.078  -13.717 -9.813  1.00 10.52 ? 148  GLY A C   1 ? 
ATOM   1173 O O   . GLY A 1 148 ? 10.767  -14.341 -8.972  1.00 10.37 ? 148  GLY A O   1 ? 
ATOM   1174 N N   . LEU A 1 149 ? 10.358  -12.461 -10.152 1.00 10.38 ? 149  LEU A N   1 ? 
ATOM   1175 C CA  . LEU A 1 149 ? 11.557  -11.764 -9.621  1.00 10.63 ? 149  LEU A CA  1 ? 
ATOM   1176 C C   . LEU A 1 149 ? 11.412  -11.588 -8.111  1.00 10.65 ? 149  LEU A C   1 ? 
ATOM   1177 O O   . LEU A 1 149 ? 12.424  -11.637 -7.415  1.00 11.31 ? 149  LEU A O   1 ? 
ATOM   1178 C CB  . LEU A 1 149 ? 11.721  -10.419 -10.331 1.00 10.80 ? 149  LEU A CB  1 ? 
ATOM   1179 C CG  . LEU A 1 149 ? 13.020  -9.681  -10.032 1.00 10.52 ? 149  LEU A CG  1 ? 
ATOM   1180 C CD1 . LEU A 1 149 ? 14.235  -10.526 -10.322 1.00 10.52 ? 149  LEU A CD1 1 ? 
ATOM   1181 C CD2 . LEU A 1 149 ? 13.107  -8.375  -10.815 1.00 10.76 ? 149  LEU A CD2 1 ? 
ATOM   1182 N N   . THR A 1 150 ? 10.203  -11.386 -7.602  1.00 9.72  ? 150  THR A N   1 ? 
ATOM   1183 C CA  . THR A 1 150 ? 9.967   -11.267 -6.135  1.00 10.02 ? 150  THR A CA  1 ? 
ATOM   1184 C C   . THR A 1 150 ? 10.460  -12.539 -5.439  1.00 10.13 ? 150  THR A C   1 ? 
ATOM   1185 O O   . THR A 1 150 ? 11.209  -12.442 -4.458  1.00 10.59 ? 150  THR A O   1 ? 
ATOM   1186 C CB  . THR A 1 150 ? 8.490   -11.005 -5.839  1.00 10.75 ? 150  THR A CB  1 ? 
ATOM   1187 O OG1 . THR A 1 150 ? 8.184   -9.690  -6.310  1.00 11.03 ? 150  THR A OG1 1 ? 
ATOM   1188 C CG2 . THR A 1 150 ? 8.141   -11.120 -4.374  1.00 11.18 ? 150  THR A CG2 1 ? 
ATOM   1189 N N   . VAL A 1 151 ? 10.086  -13.697 -5.973  1.00 10.20 ? 151  VAL A N   1 ? 
ATOM   1190 C CA  . VAL A 1 151 ? 10.487  -14.983 -5.337  1.00 10.44 ? 151  VAL A CA  1 ? 
ATOM   1191 C C   . VAL A 1 151 ? 12.000  -15.129 -5.455  1.00 10.35 ? 151  VAL A C   1 ? 
ATOM   1192 O O   . VAL A 1 151 ? 12.657  -15.476 -4.464  1.00 10.41 ? 151  VAL A O   1 ? 
ATOM   1193 C CB  . VAL A 1 151 ? 9.759   -16.173 -5.947  1.00 11.64 ? 151  VAL A CB  1 ? 
ATOM   1194 C CG1 . VAL A 1 151 ? 10.167  -17.477 -5.272  1.00 11.94 ? 151  VAL A CG1 1 ? 
ATOM   1195 C CG2 . VAL A 1 151 ? 8.260   -15.997 -5.870  1.00 11.35 ? 151  VAL A CG2 1 ? 
ATOM   1196 N N   . ALA A 1 152 ? 12.549  -14.893 -6.634  1.00 10.45 ? 152  ALA A N   1 ? 
ATOM   1197 C CA  . ALA A 1 152 ? 14.007  -15.025 -6.840  1.00 10.29 ? 152  ALA A CA  1 ? 
ATOM   1198 C C   . ALA A 1 152 ? 14.759  -14.065 -5.919  1.00 10.76 ? 152  ALA A C   1 ? 
ATOM   1199 O O   . ALA A 1 152 ? 15.800  -14.462 -5.372  1.00 11.13 ? 152  ALA A O   1 ? 
ATOM   1200 C CB  . ALA A 1 152 ? 14.347  -14.808 -8.284  1.00 10.97 ? 152  ALA A CB  1 ? 
ATOM   1201 N N   . THR A 1 153 ? 14.274  -12.842 -5.736  1.00 10.14 ? 153  THR A N   1 ? 
ATOM   1202 C CA  . THR A 1 153 ? 14.902  -11.835 -4.845  1.00 10.86 ? 153  THR A CA  1 ? 
ATOM   1203 C C   . THR A 1 153 ? 14.919  -12.366 -3.408  1.00 10.69 ? 153  THR A C   1 ? 
ATOM   1204 O O   . THR A 1 153 ? 15.964  -12.267 -2.736  1.00 11.53 ? 153  THR A O   1 ? 
ATOM   1205 C CB  . THR A 1 153 ? 14.183  -10.490 -4.925  1.00 12.05 ? 153  THR A CB  1 ? 
ATOM   1206 O OG1 . THR A 1 153 ? 14.229  -10.070 -6.286  1.00 11.48 ? 153  THR A OG1 1 ? 
ATOM   1207 C CG2 . THR A 1 153 ? 14.817  -9.434  -4.055  1.00 12.27 ? 153  THR A CG2 1 ? 
ATOM   1208 N N   . LEU A 1 154 ? 13.807  -12.922 -2.947  1.00 10.68 ? 154  LEU A N   1 ? 
ATOM   1209 C CA  . LEU A 1 154 ? 13.742  -13.478 -1.573  1.00 10.29 ? 154  LEU A CA  1 ? 
ATOM   1210 C C   . LEU A 1 154 ? 14.765  -14.604 -1.435  1.00 10.25 ? 154  LEU A C   1 ? 
ATOM   1211 O O   . LEU A 1 154 ? 15.452  -14.652 -0.409  1.00 11.98 ? 154  LEU A O   1 ? 
ATOM   1212 C CB  . LEU A 1 154 ? 12.329  -13.980 -1.283  1.00 10.66 ? 154  LEU A CB  1 ? 
ATOM   1213 C CG  . LEU A 1 154 ? 11.291  -12.869 -1.155  1.00 11.46 ? 154  LEU A CG  1 ? 
ATOM   1214 C CD1 . LEU A 1 154 ? 9.908   -13.465 -1.269  1.00 11.93 ? 154  LEU A CD1 1 ? 
ATOM   1215 C CD2 . LEU A 1 154 ? 11.495  -12.079 0.131   1.00 11.90 ? 154  LEU A CD2 1 ? 
ATOM   1216 N N   . VAL A 1 155 ? 14.821  -15.503 -2.397  1.00 10.37 ? 155  VAL A N   1 ? 
ATOM   1217 C CA  . VAL A 1 155 ? 15.786  -16.645 -2.342  1.00 11.03 ? 155  VAL A CA  1 ? 
ATOM   1218 C C   . VAL A 1 155 ? 17.210  -16.081 -2.291  1.00 11.84 ? 155  VAL A C   1 ? 
ATOM   1219 O O   . VAL A 1 155 ? 18.003  -16.512 -1.443  1.00 12.15 ? 155  VAL A O   1 ? 
ATOM   1220 C CB  . VAL A 1 155 ? 15.582  -17.575 -3.542  1.00 11.49 ? 155  VAL A CB  1 ? 
ATOM   1221 C CG1 . VAL A 1 155 ? 16.688  -18.600 -3.659  1.00 12.47 ? 155  VAL A CG1 1 ? 
ATOM   1222 C CG2 . VAL A 1 155 ? 14.250  -18.266 -3.469  1.00 11.74 ? 155  VAL A CG2 1 ? 
ATOM   1223 N N   . ALA A 1 156 ? 17.561  -15.157 -3.168  1.00 10.93 ? 156  ALA A N   1 ? 
ATOM   1224 C CA  . ALA A 1 156 ? 18.932  -14.596 -3.218  1.00 11.49 ? 156  ALA A CA  1 ? 
ATOM   1225 C C   . ALA A 1 156 ? 19.257  -13.887 -1.902  1.00 12.14 ? 156  ALA A C   1 ? 
ATOM   1226 O O   . ALA A 1 156 ? 20.382  -14.054 -1.400  1.00 13.70 ? 156  ALA A O   1 ? 
ATOM   1227 C CB  . ALA A 1 156 ? 19.065  -13.671 -4.396  1.00 12.41 ? 156  ALA A CB  1 ? 
ATOM   1228 N N   . LEU A 1 157 ? 18.345  -13.080 -1.359  1.00 12.02 ? 157  LEU A N   1 ? 
ATOM   1229 C CA  . LEU A 1 157 ? 18.560  -12.375 -0.079  1.00 11.87 ? 157  LEU A CA  1 ? 
ATOM   1230 C C   . LEU A 1 157 ? 18.772  -13.403 1.036   1.00 12.21 ? 157  LEU A C   1 ? 
ATOM   1231 O O   . LEU A 1 157 ? 19.716  -13.252 1.854   1.00 12.64 ? 157  LEU A O   1 ? 
ATOM   1232 C CB  . LEU A 1 157 ? 17.371  -11.477 0.254   1.00 11.81 ? 157  LEU A CB  1 ? 
ATOM   1233 C CG  . LEU A 1 157 ? 17.191  -10.271 -0.670  1.00 11.98 ? 157  LEU A CG  1 ? 
ATOM   1234 C CD1 . LEU A 1 157 ? 15.827  -9.663  -0.394  1.00 12.32 ? 157  LEU A CD1 1 ? 
ATOM   1235 C CD2 . LEU A 1 157 ? 18.294  -9.241  -0.470  1.00 12.43 ? 157  LEU A CD2 1 ? 
ATOM   1236 N N   . ARG A 1 158 ? 17.922  -14.423 1.094   1.00 12.05 ? 158  ARG A N   1 ? 
ATOM   1237 C CA  . ARG A 1 158 ? 18.021  -15.463 2.149   1.00 12.14 ? 158  ARG A CA  1 ? 
ATOM   1238 C C   . ARG A 1 158 ? 19.421  -16.082 2.090   1.00 12.51 ? 158  ARG A C   1 ? 
ATOM   1239 O O   . ARG A 1 158 ? 20.089  -16.215 3.144   1.00 13.87 ? 158  ARG A O   1 ? 
ATOM   1240 C CB  . ARG A 1 158 ? 16.955  -16.542 1.963   1.00 12.65 ? 158  ARG A CB  1 ? 
ATOM   1241 C CG  . ARG A 1 158 ? 16.919  -17.548 3.106   1.00 13.15 ? 158  ARG A CG  1 ? 
ATOM   1242 C CD  . ARG A 1 158 ? 16.209  -18.818 2.680   1.00 13.94 ? 158  ARG A CD  1 ? 
ATOM   1243 N NE  . ARG A 1 158 ? 16.879  -19.471 1.579   1.00 14.79 ? 158  ARG A NE  1 ? 
ATOM   1244 C CZ  . ARG A 1 158 ? 16.298  -20.043 0.565   1.00 16.55 ? 158  ARG A CZ  1 ? 
ATOM   1245 N NH1 . ARG A 1 158 ? 14.977  -20.015 0.515   1.00 18.46 ? 158  ARG A NH1 1 ? 
ATOM   1246 N NH2 . ARG A 1 158 ? 17.001  -20.536 -0.477  1.00 17.67 ? 158  ARG A NH2 1 ? 
ATOM   1247 N N   . ASP A 1 159 ? 19.865  -16.429 0.894   1.00 13.25 ? 159  ASP A N   1 ? 
ATOM   1248 C CA  . ASP A 1 159 ? 21.122  -17.186 0.674   1.00 13.61 ? 159  ASP A CA  1 ? 
ATOM   1249 C C   . ASP A 1 159 ? 22.313  -16.301 1.031   1.00 15.02 ? 159  ASP A C   1 ? 
ATOM   1250 O O   . ASP A 1 159 ? 23.380  -16.851 1.345   1.00 16.11 ? 159  ASP A O   1 ? 
ATOM   1251 C CB  . ASP A 1 159 ? 21.171  -17.708 -0.749  1.00 14.68 ? 159  ASP A CB  1 ? 
ATOM   1252 C CG  . ASP A 1 159 ? 20.193  -18.842 -1.001  1.00 16.37 ? 159  ASP A CG  1 ? 
ATOM   1253 O OD1 . ASP A 1 159 ? 19.738  -19.467 -0.010  1.00 16.69 ? 159  ASP A OD1 1 ? 
ATOM   1254 O OD2 . ASP A 1 159 ? 19.892  -19.092 -2.191  1.00 17.72 ? 159  ASP A OD2 1 ? 
ATOM   1255 N N   . ALA A 1 160 ? 22.148  -14.977 1.025   1.00 14.37 ? 160  ALA A N   1 ? 
ATOM   1256 C CA  . ALA A 1 160 ? 23.204  -14.000 1.378   1.00 14.79 ? 160  ALA A CA  1 ? 
ATOM   1257 C C   . ALA A 1 160 ? 23.132  -13.612 2.860   1.00 13.76 ? 160  ALA A C   1 ? 
ATOM   1258 O O   . ALA A 1 160 ? 23.864  -12.691 3.258   1.00 15.72 ? 160  ALA A O   1 ? 
ATOM   1259 C CB  . ALA A 1 160 ? 23.095  -12.785 0.492   1.00 15.93 ? 160  ALA A CB  1 ? 
ATOM   1260 N N   . GLY A 1 161 ? 22.294  -14.273 3.654   1.00 14.45 ? 161  GLY A N   1 ? 
ATOM   1261 C CA  . GLY A 1 161 ? 22.126  -13.985 5.094   1.00 14.55 ? 161  GLY A CA  1 ? 
ATOM   1262 C C   . GLY A 1 161 ? 21.502  -12.628 5.365   1.00 15.59 ? 161  GLY A C   1 ? 
ATOM   1263 O O   . GLY A 1 161 ? 21.738  -12.057 6.439   1.00 16.23 ? 161  GLY A O   1 ? 
ATOM   1264 N N   . VAL A 1 162 ? 20.757  -12.079 4.401   1.00 15.03 ? 162  VAL A N   1 ? 
ATOM   1265 C CA  . VAL A 1 162 ? 20.055  -10.785 4.577   1.00 14.29 ? 162  VAL A CA  1 ? 
ATOM   1266 C C   . VAL A 1 162 ? 18.731  -11.065 5.265   1.00 14.99 ? 162  VAL A C   1 ? 
ATOM   1267 O O   . VAL A 1 162 ? 18.032  -11.984 4.872   1.00 16.66 ? 162  VAL A O   1 ? 
ATOM   1268 C CB  . VAL A 1 162 ? 19.856  -10.061 3.236   1.00 15.06 ? 162  VAL A CB  1 ? 
ATOM   1269 C CG1 . VAL A 1 162 ? 19.189  -8.716  3.425   1.00 16.12 ? 162  VAL A CG1 1 ? 
ATOM   1270 C CG2 . VAL A 1 162 ? 21.158  -9.900  2.475   1.00 15.38 ? 162  VAL A CG2 1 ? 
ATOM   1271 N N   . PRO A 1 163 ? 18.324  -10.257 6.269   1.00 15.62 ? 163  PRO A N   1 ? 
ATOM   1272 C CA  . PRO A 1 163 ? 17.016  -10.446 6.883   1.00 15.84 ? 163  PRO A CA  1 ? 
ATOM   1273 C C   . PRO A 1 163 ? 15.878  -10.214 5.891   1.00 15.08 ? 163  PRO A C   1 ? 
ATOM   1274 O O   . PRO A 1 163 ? 15.849  -9.212  5.210   1.00 15.02 ? 163  PRO A O   1 ? 
ATOM   1275 C CB  . PRO A 1 163 ? 16.992  -9.428  8.022   1.00 17.05 ? 163  PRO A CB  1 ? 
ATOM   1276 C CG  . PRO A 1 163 ? 18.016  -8.414  7.655   1.00 18.57 ? 163  PRO A CG  1 ? 
ATOM   1277 C CD  . PRO A 1 163 ? 19.085  -9.170  6.898   1.00 17.85 ? 163  PRO A CD  1 ? 
ATOM   1278 N N   . LEU A 1 164 ? 14.971  -11.174 5.837   1.00 14.18 ? 164  LEU A N   1 ? 
ATOM   1279 C CA  . LEU A 1 164 ? 13.839  -11.169 4.897   1.00 13.83 ? 164  LEU A CA  1 ? 
ATOM   1280 C C   . LEU A 1 164 ? 12.731  -10.267 5.436   1.00 14.24 ? 164  LEU A C   1 ? 
ATOM   1281 O O   . LEU A 1 164 ? 12.606  -10.067 6.649   1.00 14.30 ? 164  LEU A O   1 ? 
ATOM   1282 C CB  . LEU A 1 164 ? 13.348  -12.593 4.690   1.00 14.67 ? 164  LEU A CB  1 ? 
ATOM   1283 C CG  . LEU A 1 164 ? 14.346  -13.533 4.036   1.00 14.68 ? 164  LEU A CG  1 ? 
ATOM   1284 C CD1 . LEU A 1 164 ? 13.683  -14.858 3.726   1.00 17.02 ? 164  LEU A CD1 1 ? 
ATOM   1285 C CD2 . LEU A 1 164 ? 14.902  -12.930 2.759   1.00 15.35 ? 164  LEU A CD2 1 ? 
ATOM   1286 N N   . PRO A 1 165 ? 11.892  -9.725  4.534   1.00 12.95 ? 165  PRO A N   1 ? 
ATOM   1287 C CA  . PRO A 1 165 ? 10.822  -8.805  4.923   1.00 12.86 ? 165  PRO A CA  1 ? 
ATOM   1288 C C   . PRO A 1 165 ? 9.653   -9.551  5.568   1.00 11.94 ? 165  PRO A C   1 ? 
ATOM   1289 O O   . PRO A 1 165 ? 9.652   -10.816 5.644   1.00 12.48 ? 165  PRO A O   1 ? 
ATOM   1290 C CB  . PRO A 1 165 ? 10.413  -8.155  3.585   1.00 12.91 ? 165  PRO A CB  1 ? 
ATOM   1291 C CG  . PRO A 1 165 ? 10.668  -9.269  2.584   1.00 12.51 ? 165  PRO A CG  1 ? 
ATOM   1292 C CD  . PRO A 1 165 ? 11.936  -9.939  3.077   1.00 13.00 ? 165  PRO A CD  1 ? 
ATOM   1293 N N   . ALA A 1 166 ? 8.661   -8.780  6.012   1.00 11.83 ? 166  ALA A N   1 ? 
ATOM   1294 C CA  . ALA A 1 166 ? 7.489   -9.309  6.738   1.00 12.77 ? 166  ALA A CA  1 ? 
ATOM   1295 C C   . ALA A 1 166 ? 6.625   -10.185 5.839   1.00 12.57 ? 166  ALA A C   1 ? 
ATOM   1296 O O   . ALA A 1 166 ? 5.979   -11.113 6.355   1.00 12.86 ? 166  ALA A O   1 ? 
ATOM   1297 C CB  . ALA A 1 166 ? 6.680   -8.180  7.296   1.00 14.42 ? 166  ALA A CB  1 ? 
ATOM   1298 N N   . ALA A 1 167 ? 6.579   -9.901  4.537   1.00 10.91 ? 167  ALA A N   1 ? 
ATOM   1299 C CA  . ALA A 1 167 ? 5.657   -10.588 3.626   1.00 11.64 ? 167  ALA A CA  1 ? 
ATOM   1300 C C   . ALA A 1 167 ? 6.048   -10.303 2.187   1.00 10.85 ? 167  ALA A C   1 ? 
ATOM   1301 O O   . ALA A 1 167 ? 6.898   -9.417  1.957   1.00 11.68 ? 167  ALA A O   1 ? 
ATOM   1302 C CB  . ALA A 1 167 ? 4.239   -10.163 3.897   1.00 13.29 ? 167  ALA A CB  1 ? 
ATOM   1303 N N   . ALA A 1 168 ? 5.465   -11.030 1.255   1.00 9.63  ? 168  ALA A N   1 ? 
ATOM   1304 C CA  . ALA A 1 168 ? 5.697   -10.779 -0.168  1.00 10.12 ? 168  ALA A CA  1 ? 
ATOM   1305 C C   . ALA A 1 168 ? 4.423   -11.069 -0.925  1.00 10.28 ? 168  ALA A C   1 ? 
ATOM   1306 O O   . ALA A 1 168 ? 3.560   -11.840 -0.454  1.00 10.36 ? 168  ALA A O   1 ? 
ATOM   1307 C CB  . ALA A 1 168 ? 6.842   -11.583 -0.693  1.00 10.26 ? 168  ALA A CB  1 ? 
ATOM   1308 N N   . VAL A 1 169 ? 4.303   -10.431 -2.086  1.00 10.26 ? 169  VAL A N   1 ? 
ATOM   1309 C CA  . VAL A 1 169 ? 3.066   -10.508 -2.895  1.00 10.51 ? 169  VAL A CA  1 ? 
ATOM   1310 C C   . VAL A 1 169 ? 3.456   -10.742 -4.348  1.00 10.47 ? 169  VAL A C   1 ? 
ATOM   1311 O O   . VAL A 1 169 ? 4.304   -10.003 -4.865  1.00 11.58 ? 169  VAL A O   1 ? 
ATOM   1312 C CB  . VAL A 1 169 ? 2.247   -9.215  -2.785  1.00 10.99 ? 169  VAL A CB  1 ? 
ATOM   1313 C CG1 . VAL A 1 169 ? 1.033   -9.301  -3.685  1.00 12.25 ? 169  VAL A CG1 1 ? 
ATOM   1314 C CG2 . VAL A 1 169 ? 1.850   -8.931  -1.349  1.00 11.87 ? 169  VAL A CG2 1 ? 
ATOM   1315 N N   . CYS A 1 170 ? 2.832   -11.715 -4.992  1.00 10.29 ? 170  CYS A N   1 ? 
ATOM   1316 C CA  . CYS A 1 170 ? 3.064   -12.091 -6.407  1.00 11.51 ? 170  CYS A CA  1 ? 
ATOM   1317 C C   . CYS A 1 170 ? 1.737   -11.967 -7.139  1.00 11.84 ? 170  CYS A C   1 ? 
ATOM   1318 O O   . CYS A 1 170 ? 0.774   -12.628 -6.729  1.00 12.16 ? 170  CYS A O   1 ? 
ATOM   1319 C CB  . CYS A 1 170 ? 3.563   -13.522 -6.541  1.00 11.67 ? 170  CYS A CB  1 ? 
ATOM   1320 S SG  . CYS A 1 170 ? 5.132   -13.831 -5.701  1.00 15.87 ? 170  CYS A SG  1 ? 
ATOM   1321 N N   . LEU A 1 171 ? 1.680   -11.138 -8.179  1.00 11.02 ? 171  LEU A N   1 ? 
ATOM   1322 C CA  . LEU A 1 171 ? 0.451   -10.965 -8.991  1.00 11.59 ? 171  LEU A CA  1 ? 
ATOM   1323 C C   . LEU A 1 171 ? 0.670   -11.693 -10.316 1.00 11.74 ? 171  LEU A C   1 ? 
ATOM   1324 O O   . LEU A 1 171 ? 1.514   -11.233 -11.104 1.00 12.16 ? 171  LEU A O   1 ? 
ATOM   1325 C CB  . LEU A 1 171 ? 0.182   -9.464  -9.191  1.00 12.20 ? 171  LEU A CB  1 ? 
ATOM   1326 C CG  . LEU A 1 171 ? 0.151   -8.587  -7.940  1.00 13.01 ? 171  LEU A CG  1 ? 
ATOM   1327 C CD1 . LEU A 1 171 ? -0.278  -7.167  -8.307  1.00 13.55 ? 171  LEU A CD1 1 ? 
ATOM   1328 C CD2 . LEU A 1 171 ? -0.735  -9.158  -6.846  1.00 13.96 ? 171  LEU A CD2 1 ? 
ATOM   1329 N N   . SER A 1 172 ? -0.022  -12.799 -10.564 1.00 11.56 ? 172  SER A N   1 ? 
ATOM   1330 C CA  . SER A 1 172 ? 0.101   -13.577 -11.819 1.00 12.43 ? 172  SER A CA  1 ? 
ATOM   1331 C C   . SER A 1 172 ? 1.574   -13.860 -12.101 1.00 11.49 ? 172  SER A C   1 ? 
ATOM   1332 O O   . SER A 1 172 ? 2.044   -13.578 -13.201 1.00 11.86 ? 172  SER A O   1 ? 
ATOM   1333 C CB  . SER A 1 172 ? -0.501  -12.851 -13.001 1.00 14.82 ? 172  SER A CB  1 ? 
ATOM   1334 O OG  . SER A 1 172 ? -1.832  -12.416 -12.764 1.00 17.93 ? 172  SER A OG  1 ? 
ATOM   1335 N N   . PRO A 1 173 ? 2.358   -14.423 -11.155 1.00 10.40 ? 173  PRO A N   1 ? 
ATOM   1336 C CA  . PRO A 1 173 ? 3.794   -14.584 -11.372 1.00 11.03 ? 173  PRO A CA  1 ? 
ATOM   1337 C C   . PRO A 1 173 ? 4.138   -15.512 -12.529 1.00 10.91 ? 173  PRO A C   1 ? 
ATOM   1338 O O   . PRO A 1 173 ? 3.461   -16.494 -12.773 1.00 12.89 ? 173  PRO A O   1 ? 
ATOM   1339 C CB  . PRO A 1 173 ? 4.302   -15.192 -10.052 1.00 10.72 ? 173  PRO A CB  1 ? 
ATOM   1340 C CG  . PRO A 1 173 ? 3.079   -15.860 -9.483  1.00 11.29 ? 173  PRO A CG  1 ? 
ATOM   1341 C CD  . PRO A 1 173 ? 1.959   -14.905 -9.821  1.00 11.22 ? 173  PRO A CD  1 ? 
ATOM   1342 N N   . TRP A 1 174 ? 5.233   -15.173 -13.201 1.00 10.60 ? 174  TRP A N   1 ? 
ATOM   1343 C CA  . TRP A 1 174 ? 5.838   -15.989 -14.269 1.00 11.19 ? 174  TRP A CA  1 ? 
ATOM   1344 C C   . TRP A 1 174 ? 7.067   -16.687 -13.680 1.00 11.96 ? 174  TRP A C   1 ? 
ATOM   1345 O O   . TRP A 1 174 ? 8.072   -16.007 -13.408 1.00 12.16 ? 174  TRP A O   1 ? 
ATOM   1346 C CB  . TRP A 1 174 ? 6.198   -15.130 -15.469 1.00 11.53 ? 174  TRP A CB  1 ? 
ATOM   1347 C CG  . TRP A 1 174 ? 6.733   -15.939 -16.603 1.00 11.59 ? 174  TRP A CG  1 ? 
ATOM   1348 C CD1 . TRP A 1 174 ? 6.426   -17.225 -16.940 1.00 12.16 ? 174  TRP A CD1 1 ? 
ATOM   1349 C CD2 . TRP A 1 174 ? 7.631   -15.463 -17.611 1.00 12.29 ? 174  TRP A CD2 1 ? 
ATOM   1350 N NE1 . TRP A 1 174 ? 7.081   -17.594 -18.079 1.00 12.26 ? 174  TRP A NE1 1 ? 
ATOM   1351 C CE2 . TRP A 1 174 ? 7.830   -16.528 -18.512 1.00 12.16 ? 174  TRP A CE2 1 ? 
ATOM   1352 C CE3 . TRP A 1 174 ? 8.311   -14.258 -17.814 1.00 12.24 ? 174  TRP A CE3 1 ? 
ATOM   1353 C CZ2 . TRP A 1 174 ? 8.680   -16.412 -19.606 1.00 12.58 ? 174  TRP A CZ2 1 ? 
ATOM   1354 C CZ3 . TRP A 1 174 ? 9.136   -14.137 -18.911 1.00 13.35 ? 174  TRP A CZ3 1 ? 
ATOM   1355 C CH2 . TRP A 1 174 ? 9.314   -15.201 -19.795 1.00 12.28 ? 174  TRP A CH2 1 ? 
ATOM   1356 N N   . VAL A 1 175 ? 6.968   -17.994 -13.441 1.00 12.57 ? 175  VAL A N   1 ? 
ATOM   1357 C CA  . VAL A 1 175 ? 8.054   -18.755 -12.763 1.00 13.28 ? 175  VAL A CA  1 ? 
ATOM   1358 C C   . VAL A 1 175 ? 8.510   -19.972 -13.573 1.00 13.07 ? 175  VAL A C   1 ? 
ATOM   1359 O O   . VAL A 1 175 ? 9.515   -20.547 -13.155 1.00 15.31 ? 175  VAL A O   1 ? 
ATOM   1360 C CB  . VAL A 1 175 ? 7.668   -19.168 -11.336 1.00 13.95 ? 175  VAL A CB  1 ? 
ATOM   1361 C CG1 . VAL A 1 175 ? 7.528   -17.952 -10.444 1.00 14.63 ? 175  VAL A CG1 1 ? 
ATOM   1362 C CG2 . VAL A 1 175 ? 6.438   -20.048 -11.298 1.00 15.45 ? 175  VAL A CG2 1 ? 
ATOM   1363 N N   . ASP A 1 176 ? 7.835   -20.307 -14.670 1.00 12.66 ? 176  ASP A N   1 ? 
ATOM   1364 C CA  . ASP A 1 176 ? 8.152   -21.425 -15.600 1.00 13.28 ? 176  ASP A CA  1 ? 
ATOM   1365 C C   . ASP A 1 176 ? 8.497   -20.831 -16.957 1.00 13.23 ? 176  ASP A C   1 ? 
ATOM   1366 O O   . ASP A 1 176 ? 7.573   -20.443 -17.696 1.00 14.35 ? 176  ASP A O   1 ? 
ATOM   1367 C CB  . ASP A 1 176 ? 6.965   -22.377 -15.726 1.00 14.43 ? 176  ASP A CB  1 ? 
ATOM   1368 C CG  . ASP A 1 176 ? 7.066   -23.393 -16.852 1.00 14.47 ? 176  ASP A CG  1 ? 
ATOM   1369 O OD1 . ASP A 1 176 ? 8.170   -23.569 -17.387 1.00 16.09 ? 176  ASP A OD1 1 ? 
ATOM   1370 O OD2 . ASP A 1 176 ? 6.016   -23.981 -17.177 1.00 15.99 ? 176  ASP A OD2 1 ? 
ATOM   1371 N N   . LEU A 1 177 ? 9.781   -20.701 -17.250 1.00 13.44 ? 177  LEU A N   1 ? 
ATOM   1372 C CA  . LEU A 1 177 ? 10.247  -20.020 -18.486 1.00 14.84 ? 177  LEU A CA  1 ? 
ATOM   1373 C C   . LEU A 1 177 ? 10.167  -20.974 -19.684 1.00 14.59 ? 177  LEU A C   1 ? 
ATOM   1374 O O   . LEU A 1 177 ? 10.558  -20.536 -20.781 1.00 15.92 ? 177  LEU A O   1 ? 
ATOM   1375 C CB  . LEU A 1 177 ? 11.669  -19.509 -18.289 1.00 15.51 ? 177  LEU A CB  1 ? 
ATOM   1376 C CG  . LEU A 1 177 ? 11.875  -18.522 -17.137 1.00 18.70 ? 177  LEU A CG  1 ? 
ATOM   1377 C CD1 . LEU A 1 177 ? 13.212  -17.817 -17.227 1.00 19.08 ? 177  LEU A CD1 1 ? 
ATOM   1378 C CD2 . LEU A 1 177 ? 10.752  -17.518 -16.957 1.00 19.54 ? 177  LEU A CD2 1 ? 
ATOM   1379 N N   . GLU A 1 178 ? 9.697   -22.215 -19.510 1.00 14.49 ? 178  GLU A N   1 ? 
ATOM   1380 C CA  . GLU A 1 178 ? 9.464   -23.166 -20.634 1.00 14.98 ? 178  GLU A CA  1 ? 
ATOM   1381 C C   . GLU A 1 178 ? 7.999   -23.196 -21.069 1.00 15.49 ? 178  GLU A C   1 ? 
ATOM   1382 O O   . GLU A 1 178 ? 7.725   -23.751 -22.147 1.00 16.56 ? 178  GLU A O   1 ? 
ATOM   1383 C CB  . GLU A 1 178 ? 9.901   -24.573 -20.234 1.00 16.56 ? 178  GLU A CB  1 ? 
ATOM   1384 C CG  . GLU A 1 178 ? 11.379  -24.672 -19.968 1.00 18.60 ? 178  GLU A CG  1 ? 
ATOM   1385 C CD  . GLU A 1 178 ? 11.825  -26.091 -19.675 1.00 22.43 ? 178  GLU A CD  1 ? 
ATOM   1386 O OE1 . GLU A 1 178 ? 11.365  -26.652 -18.668 1.00 22.37 ? 178  GLU A OE1 1 ? 
ATOM   1387 O OE2 . GLU A 1 178 ? 12.633  -26.620 -20.471 1.00 27.16 ? 178  GLU A OE2 1 ? 
ATOM   1388 N N   . GLY A 1 179 ? 7.063   -22.650 -20.295 1.00 16.02 ? 179  GLY A N   1 ? 
ATOM   1389 C CA  . GLY A 1 179 ? 5.629   -22.695 -20.641 1.00 16.57 ? 179  GLY A CA  1 ? 
ATOM   1390 C C   . GLY A 1 179 ? 5.127   -24.126 -20.804 1.00 17.76 ? 179  GLY A C   1 ? 
ATOM   1391 O O   . GLY A 1 179 ? 4.501   -24.432 -21.839 1.00 19.12 ? 179  GLY A O   1 ? 
ATOM   1392 N N   . ILE A 1 180 ? 5.348   -24.971 -19.802 1.00 16.97 ? 180  ILE A N   1 ? 
ATOM   1393 C CA  . ILE A 1 180 ? 4.935   -26.404 -19.841 1.00 18.46 ? 180  ILE A CA  1 ? 
ATOM   1394 C C   . ILE A 1 180 ? 3.810   -26.664 -18.835 1.00 19.13 ? 180  ILE A C   1 ? 
ATOM   1395 O O   . ILE A 1 180 ? 3.448   -27.849 -18.637 1.00 22.17 ? 180  ILE A O   1 ? 
ATOM   1396 C CB  . ILE A 1 180 ? 6.145   -27.329 -19.626 1.00 19.49 ? 180  ILE A CB  1 ? 
ATOM   1397 C CG1 . ILE A 1 180 ? 6.792   -27.120 -18.252 1.00 20.88 ? 180  ILE A CG1 1 ? 
ATOM   1398 C CG2 . ILE A 1 180 ? 7.124   -27.188 -20.787 1.00 21.27 ? 180  ILE A CG2 1 ? 
ATOM   1399 C CD1 . ILE A 1 180 ? 7.850   -28.138 -17.918 1.00 22.47 ? 180  ILE A CD1 1 ? 
ATOM   1400 N N   . GLY A 1 181 ? 3.268   -25.631 -18.187 1.00 17.55 ? 181  GLY A N   1 ? 
ATOM   1401 C CA  . GLY A 1 181 ? 2.076   -25.805 -17.343 1.00 17.43 ? 181  GLY A CA  1 ? 
ATOM   1402 C C   . GLY A 1 181 ? 0.878   -26.236 -18.170 1.00 17.87 ? 181  GLY A C   1 ? 
ATOM   1403 O O   . GLY A 1 181 ? 0.765   -25.810 -19.328 1.00 17.04 ? 181  GLY A O   1 ? 
ATOM   1404 N N   . GLU A 1 182 ? -0.031  -27.013 -17.591 1.00 18.73 ? 182  GLU A N   1 ? 
ATOM   1405 C CA  . GLU A 1 182 ? -1.251  -27.452 -18.321 1.00 19.96 ? 182  GLU A CA  1 ? 
ATOM   1406 C C   . GLU A 1 182 ? -2.055  -26.246 -18.839 1.00 19.12 ? 182  GLU A C   1 ? 
ATOM   1407 O O   . GLU A 1 182 ? -2.533  -26.304 -19.996 1.00 17.75 ? 182  GLU A O   1 ? 
ATOM   1408 C CB  . GLU A 1 182 ? -2.105  -28.361 -17.439 1.00 23.25 ? 182  GLU A CB  1 ? 
ATOM   1409 C CG  . GLU A 1 182 ? -3.396  -28.797 -18.104 1.00 28.35 ? 182  GLU A CG  1 ? 
ATOM   1410 C CD  . GLU A 1 182 ? -4.105  -29.937 -17.389 1.00 35.80 ? 182  GLU A CD  1 ? 
ATOM   1411 O OE1 . GLU A 1 182 ? -3.927  -30.053 -16.158 1.00 41.20 ? 182  GLU A OE1 1 ? 
ATOM   1412 O OE2 . GLU A 1 182 ? -4.816  -30.714 -18.068 1.00 40.08 ? 182  GLU A OE2 1 ? 
ATOM   1413 N N   . SER A 1 183 ? -2.203  -25.176 -18.046 1.00 16.74 ? 183  SER A N   1 ? 
ATOM   1414 C CA  . SER A 1 183 ? -3.003  -23.986 -18.437 1.00 15.63 ? 183  SER A CA  1 ? 
ATOM   1415 C C   . SER A 1 183 ? -2.409  -23.312 -19.680 1.00 14.73 ? 183  SER A C   1 ? 
ATOM   1416 O O   . SER A 1 183 ? -3.144  -22.554 -20.349 1.00 16.32 ? 183  SER A O   1 ? 
ATOM   1417 C CB  . SER A 1 183 ? -3.158  -23.013 -17.300 1.00 16.02 ? 183  SER A CB  1 ? 
ATOM   1418 O OG  . SER A 1 183 ? -1.889  -22.638 -16.780 1.00 15.32 ? 183  SER A OG  1 ? 
ATOM   1419 N N   . MET A 1 184 ? -1.121  -23.521 -19.977 1.00 15.15 ? 184  MET A N   1 ? 
ATOM   1420 C CA  . MET A 1 184 ? -0.510  -22.852 -21.157 1.00 17.10 ? 184  MET A CA  1 ? 
ATOM   1421 C C   . MET A 1 184 ? -1.203  -23.385 -22.417 1.00 19.11 ? 184  MET A C   1 ? 
ATOM   1422 O O   . MET A 1 184 ? -1.330  -22.624 -23.406 1.00 20.58 ? 184  MET A O   1 ? 
ATOM   1423 C CB  . MET A 1 184 ? 0.996   -23.102 -21.206 1.00 17.91 ? 184  MET A CB  1 ? 
ATOM   1424 C CG  . MET A 1 184 ? 1.723   -22.284 -22.243 1.00 18.70 ? 184  MET A CG  1 ? 
ATOM   1425 S SD  . MET A 1 184 ? 1.550   -20.482 -22.054 1.00 18.19 ? 184  MET A SD  1 ? 
ATOM   1426 C CE  . MET A 1 184 ? 1.972   -20.176 -20.335 1.00 17.83 ? 184  MET A CE  1 ? 
ATOM   1427 N N   . THR A 1 185 ? -1.744  -24.603 -22.329 1.00 20.46 ? 185  THR A N   1 ? 
ATOM   1428 C CA  . THR A 1 185 ? -2.632  -25.207 -23.367 1.00 21.84 ? 185  THR A CA  1 ? 
ATOM   1429 C C   . THR A 1 185 ? -4.105  -24.919 -23.072 1.00 21.68 ? 185  THR A C   1 ? 
ATOM   1430 O O   . THR A 1 185 ? -4.805  -24.386 -23.973 1.00 22.00 ? 185  THR A O   1 ? 
ATOM   1431 C CB  . THR A 1 185 ? -2.394  -26.713 -23.494 1.00 23.75 ? 185  THR A CB  1 ? 
ATOM   1432 O OG1 . THR A 1 185 ? -1.009  -26.865 -23.783 1.00 27.61 ? 185  THR A OG1 1 ? 
ATOM   1433 C CG2 . THR A 1 185 ? -3.225  -27.356 -24.582 1.00 27.29 ? 185  THR A CG2 1 ? 
ATOM   1434 N N   . THR A 1 186 ? -4.599  -25.264 -21.880 1.00 21.86 ? 186  THR A N   1 ? 
ATOM   1435 C CA  . THR A 1 186 ? -6.064  -25.307 -21.628 1.00 21.98 ? 186  THR A CA  1 ? 
ATOM   1436 C C   . THR A 1 186 ? -6.678  -23.907 -21.516 1.00 22.35 ? 186  THR A C   1 ? 
ATOM   1437 O O   . THR A 1 186 ? -7.903  -23.817 -21.666 1.00 25.44 ? 186  THR A O   1 ? 
ATOM   1438 C CB  . THR A 1 186 ? -6.399  -26.150 -20.398 1.00 23.03 ? 186  THR A CB  1 ? 
ATOM   1439 O OG1 . THR A 1 186 ? -5.740  -25.565 -19.277 1.00 21.88 ? 186  THR A OG1 1 ? 
ATOM   1440 C CG2 . THR A 1 186 ? -5.956  -27.588 -20.535 1.00 25.25 ? 186  THR A CG2 1 ? 
ATOM   1441 N N   . LYS A 1 187 ? -5.899  -22.856 -21.229 1.00 20.80 ? 187  LYS A N   1 ? 
ATOM   1442 C CA  . LYS A 1 187 ? -6.442  -21.486 -21.055 1.00 19.69 ? 187  LYS A CA  1 ? 
ATOM   1443 C C   . LYS A 1 187 ? -6.034  -20.593 -22.222 1.00 18.73 ? 187  LYS A C   1 ? 
ATOM   1444 O O   . LYS A 1 187 ? -6.382  -19.416 -22.169 1.00 18.47 ? 187  LYS A O   1 ? 
ATOM   1445 C CB  . LYS A 1 187 ? -5.987  -20.849 -19.740 1.00 19.83 ? 187  LYS A CB  1 ? 
ATOM   1446 C CG  . LYS A 1 187 ? -6.371  -21.625 -18.487 1.00 22.00 ? 187  LYS A CG  1 ? 
ATOM   1447 C CD  . LYS A 1 187 ? -7.842  -21.599 -18.219 1.00 24.43 ? 187  LYS A CD  1 ? 
ATOM   1448 C CE  . LYS A 1 187 ? -8.177  -22.335 -16.935 1.00 26.65 ? 187  LYS A CE  1 ? 
ATOM   1449 N NZ  . LYS A 1 187 ? -9.519  -21.953 -16.452 1.00 30.65 ? 187  LYS A NZ  1 ? 
ATOM   1450 N N   . ALA A 1 188 ? -5.384  -21.136 -23.243 1.00 19.64 ? 188  ALA A N   1 ? 
ATOM   1451 C CA  . ALA A 1 188 ? -4.927  -20.346 -24.412 1.00 21.30 ? 188  ALA A CA  1 ? 
ATOM   1452 C C   . ALA A 1 188 ? -6.116  -19.621 -25.072 1.00 23.47 ? 188  ALA A C   1 ? 
ATOM   1453 O O   . ALA A 1 188 ? -5.951  -18.478 -25.529 1.00 22.47 ? 188  ALA A O   1 ? 
ATOM   1454 C CB  . ALA A 1 188 ? -4.210  -21.247 -25.382 1.00 21.99 ? 188  ALA A CB  1 ? 
ATOM   1455 N N   . ALA A 1 189 ? -7.291  -20.246 -25.134 1.00 24.30 ? 189  ALA A N   1 ? 
ATOM   1456 C CA  . ALA A 1 189 ? -8.483  -19.658 -25.788 1.00 24.84 ? 189  ALA A CA  1 ? 
ATOM   1457 C C   . ALA A 1 189 ? -8.997  -18.425 -25.038 1.00 25.10 ? 189  ALA A C   1 ? 
ATOM   1458 O O   . ALA A 1 189 ? -9.480  -17.480 -25.718 1.00 28.32 ? 189  ALA A O   1 ? 
ATOM   1459 C CB  . ALA A 1 189 ? -9.565  -20.695 -25.909 1.00 25.84 ? 189  ALA A CB  1 ? 
ATOM   1460 N N   . VAL A 1 190 ? -8.875  -18.386 -23.703 1.00 22.29 ? 190  VAL A N   1 ? 
ATOM   1461 C CA  . VAL A 1 190 ? -9.521  -17.332 -22.865 1.00 21.83 ? 190  VAL A CA  1 ? 
ATOM   1462 C C   . VAL A 1 190 ? -8.509  -16.266 -22.424 1.00 20.42 ? 190  VAL A C   1 ? 
ATOM   1463 O O   . VAL A 1 190 ? -8.948  -15.296 -21.781 1.00 21.55 ? 190  VAL A O   1 ? 
ATOM   1464 C CB  . VAL A 1 190 ? -10.233 -17.922 -21.632 1.00 22.86 ? 190  VAL A CB  1 ? 
ATOM   1465 C CG1 . VAL A 1 190 ? -11.383 -18.813 -22.073 1.00 24.04 ? 190  VAL A CG1 1 ? 
ATOM   1466 C CG2 . VAL A 1 190 ? -9.286  -18.663 -20.687 1.00 22.67 ? 190  VAL A CG2 1 ? 
ATOM   1467 N N   . ASP A 1 191 ? -7.218  -16.445 -22.719 1.00 19.00 ? 191  ASP A N   1 ? 
ATOM   1468 C CA  . ASP A 1 191 ? -6.175  -15.468 -22.305 1.00 17.63 ? 191  ASP A CA  1 ? 
ATOM   1469 C C   . ASP A 1 191 ? -5.941  -14.497 -23.452 1.00 17.83 ? 191  ASP A C   1 ? 
ATOM   1470 O O   . ASP A 1 191 ? -5.398  -14.888 -24.473 1.00 20.22 ? 191  ASP A O   1 ? 
ATOM   1471 C CB  . ASP A 1 191 ? -4.884  -16.169 -21.893 1.00 16.21 ? 191  ASP A CB  1 ? 
ATOM   1472 C CG  . ASP A 1 191 ? -3.889  -15.234 -21.214 1.00 15.78 ? 191  ASP A CG  1 ? 
ATOM   1473 O OD1 . ASP A 1 191 ? -3.872  -14.005 -21.544 1.00 16.13 ? 191  ASP A OD1 1 ? 
ATOM   1474 O OD2 . ASP A 1 191 ? -3.107  -15.748 -20.350 1.00 15.91 ? 191  ASP A OD2 1 ? 
ATOM   1475 N N   . PRO A 1 192 ? -6.325  -13.211 -23.298 1.00 18.01 ? 192  PRO A N   1 ? 
ATOM   1476 C CA  . PRO A 1 192 ? -6.168  -12.239 -24.383 1.00 19.38 ? 192  PRO A CA  1 ? 
ATOM   1477 C C   . PRO A 1 192 ? -4.807  -11.542 -24.453 1.00 21.20 ? 192  PRO A C   1 ? 
ATOM   1478 O O   . PRO A 1 192 ? -4.640  -10.697 -25.315 1.00 21.44 ? 192  PRO A O   1 ? 
ATOM   1479 C CB  . PRO A 1 192 ? -7.254  -11.214 -24.026 1.00 19.67 ? 192  PRO A CB  1 ? 
ATOM   1480 C CG  . PRO A 1 192 ? -7.171  -11.167 -22.513 1.00 20.13 ? 192  PRO A CG  1 ? 
ATOM   1481 C CD  . PRO A 1 192 ? -6.995  -12.621 -22.121 1.00 18.77 ? 192  PRO A CD  1 ? 
ATOM   1482 N N   . MET A 1 193 ? -3.888  -11.864 -23.537 1.00 19.08 ? 193  MET A N   1 ? 
ATOM   1483 C CA  . MET A 1 193 ? -2.596  -11.153 -23.405 1.00 19.42 ? 193  MET A CA  1 ? 
ATOM   1484 C C   . MET A 1 193 ? -1.405  -12.098 -23.544 1.00 18.53 ? 193  MET A C   1 ? 
ATOM   1485 O O   . MET A 1 193 ? -0.451  -11.755 -24.260 1.00 20.19 ? 193  MET A O   1 ? 
ATOM   1486 C CB  . MET A 1 193 ? -2.495  -10.452 -22.054 1.00 21.96 ? 193  MET A CB  1 ? 
ATOM   1487 C CG  . MET A 1 193 ? -1.458  -9.365  -22.076 1.00 26.02 ? 193  MET A CG  1 ? 
ATOM   1488 S SD  . MET A 1 193 ? -1.073  -8.842  -20.420 1.00 31.75 ? 193  MET A SD  1 ? 
ATOM   1489 C CE  . MET A 1 193 ? -2.626  -8.133  -19.880 1.00 30.92 ? 193  MET A CE  1 ? 
ATOM   1490 N N   . VAL A 1 194 ? -1.424  -13.227 -22.842 1.00 15.28 ? 194  VAL A N   1 ? 
ATOM   1491 C CA  . VAL A 1 194 ? -0.240  -14.107 -22.683 1.00 16.13 ? 194  VAL A CA  1 ? 
ATOM   1492 C C   . VAL A 1 194 ? -0.479  -15.397 -23.448 1.00 17.07 ? 194  VAL A C   1 ? 
ATOM   1493 O O   . VAL A 1 194 ? -1.534  -16.042 -23.257 1.00 16.97 ? 194  VAL A O   1 ? 
ATOM   1494 C CB  . VAL A 1 194 ? 0.057   -14.406 -21.208 1.00 16.04 ? 194  VAL A CB  1 ? 
ATOM   1495 C CG1 . VAL A 1 194 ? 1.284   -15.288 -21.066 1.00 16.42 ? 194  VAL A CG1 1 ? 
ATOM   1496 C CG2 . VAL A 1 194 ? 0.226   -13.132 -20.424 1.00 17.16 ? 194  VAL A CG2 1 ? 
ATOM   1497 N N   . GLN A 1 195 ? 0.467   -15.736 -24.306 1.00 17.23 ? 195  GLN A N   1 ? 
ATOM   1498 C CA  . GLN A 1 195 ? 0.496   -17.048 -24.985 1.00 17.34 ? 195  GLN A CA  1 ? 
ATOM   1499 C C   . GLN A 1 195 ? 1.914   -17.597 -24.927 1.00 17.72 ? 195  GLN A C   1 ? 
ATOM   1500 O O   . GLN A 1 195 ? 2.860   -16.867 -24.597 1.00 17.29 ? 195  GLN A O   1 ? 
ATOM   1501 C CB  . GLN A 1 195 ? 0.013   -16.910 -26.427 1.00 19.03 ? 195  GLN A CB  1 ? 
ATOM   1502 C CG  . GLN A 1 195 ? -1.421  -16.423 -26.555 1.00 20.34 ? 195  GLN A CG  1 ? 
ATOM   1503 C CD  . GLN A 1 195 ? -2.445  -17.423 -26.078 1.00 21.55 ? 195  GLN A CD  1 ? 
ATOM   1504 O OE1 . GLN A 1 195 ? -2.253  -18.636 -26.140 1.00 26.95 ? 195  GLN A OE1 1 ? 
ATOM   1505 N NE2 . GLN A 1 195 ? -3.545  -16.912 -25.573 1.00 22.49 ? 195  GLN A NE2 1 ? 
ATOM   1506 N N   . ARG A 1 196 ? 2.079   -18.847 -25.311 1.00 16.26 ? 196  ARG A N   1 ? 
ATOM   1507 C CA  . ARG A 1 196 ? 3.374   -19.527 -25.165 1.00 17.35 ? 196  ARG A CA  1 ? 
ATOM   1508 C C   . ARG A 1 196 ? 4.417   -18.840 -26.047 1.00 17.51 ? 196  ARG A C   1 ? 
ATOM   1509 O O   . ARG A 1 196 ? 5.545   -18.634 -25.580 1.00 15.82 ? 196  ARG A O   1 ? 
ATOM   1510 C CB  . ARG A 1 196 ? 3.224   -21.013 -25.486 1.00 18.48 ? 196  ARG A CB  1 ? 
ATOM   1511 C CG  . ARG A 1 196 ? 4.428   -21.812 -25.039 1.00 20.05 ? 196  ARG A CG  1 ? 
ATOM   1512 C CD  . ARG A 1 196 ? 4.217   -23.311 -25.128 1.00 23.37 ? 196  ARG A CD  1 ? 
ATOM   1513 N NE  . ARG A 1 196 ? 5.344   -23.976 -24.514 1.00 24.23 ? 196  ARG A NE  1 ? 
ATOM   1514 C CZ  . ARG A 1 196 ? 6.260   -24.714 -25.132 1.00 28.31 ? 196  ARG A CZ  1 ? 
ATOM   1515 N NH1 . ARG A 1 196 ? 6.210   -24.913 -26.441 1.00 30.14 ? 196  ARG A NH1 1 ? 
ATOM   1516 N NH2 . ARG A 1 196 ? 7.240   -25.256 -24.426 1.00 32.44 ? 196  ARG A NH2 1 ? 
ATOM   1517 N N   . GLU A 1 197 ? 4.089   -18.490 -27.284 1.00 18.54 ? 197  GLU A N   1 ? 
ATOM   1518 C CA  . GLU A 1 197 ? 5.114   -18.003 -28.242 1.00 20.44 ? 197  GLU A CA  1 ? 
ATOM   1519 C C   . GLU A 1 197 ? 5.748   -16.706 -27.720 1.00 17.41 ? 197  GLU A C   1 ? 
ATOM   1520 O O   . GLU A 1 197 ? 6.962   -16.626 -27.655 1.00 16.05 ? 197  GLU A O   1 ? 
ATOM   1521 C CB  . GLU A 1 197 ? 4.526   -17.907 -29.657 1.00 24.87 ? 197  GLU A CB  1 ? 
ATOM   1522 C CG  . GLU A 1 197 ? 4.554   -19.250 -30.379 1.00 32.26 ? 197  GLU A CG  1 ? 
ATOM   1523 C CD  . GLU A 1 197 ? 4.300   -19.230 -31.886 1.00 40.95 ? 197  GLU A CD  1 ? 
ATOM   1524 O OE1 . GLU A 1 197 ? 5.166   -18.693 -32.628 1.00 47.08 ? 197  GLU A OE1 1 ? 
ATOM   1525 O OE2 . GLU A 1 197 ? 3.240   -19.765 -32.330 1.00 47.81 ? 197  GLU A OE2 1 ? 
ATOM   1526 N N   . PRO A 1 198 ? 4.992   -15.676 -27.309 1.00 18.10 ? 198  PRO A N   1 ? 
ATOM   1527 C CA  . PRO A 1 198 ? 5.608   -14.474 -26.754 1.00 18.27 ? 198  PRO A CA  1 ? 
ATOM   1528 C C   . PRO A 1 198 ? 6.397   -14.728 -25.462 1.00 17.85 ? 198  PRO A C   1 ? 
ATOM   1529 O O   . PRO A 1 198 ? 7.469   -14.144 -25.256 1.00 16.65 ? 198  PRO A O   1 ? 
ATOM   1530 C CB  . PRO A 1 198 ? 4.451   -13.508 -26.471 1.00 20.47 ? 198  PRO A CB  1 ? 
ATOM   1531 C CG  . PRO A 1 198 ? 3.262   -14.073 -27.229 1.00 22.26 ? 198  PRO A CG  1 ? 
ATOM   1532 C CD  . PRO A 1 198 ? 3.531   -15.538 -27.456 1.00 19.71 ? 198  PRO A CD  1 ? 
ATOM   1533 N N   . LEU A 1 199 ? 5.899   -15.605 -24.597 1.00 15.55 ? 199  LEU A N   1 ? 
ATOM   1534 C CA  . LEU A 1 199 ? 6.654   -15.945 -23.374 1.00 15.79 ? 199  LEU A CA  1 ? 
ATOM   1535 C C   . LEU A 1 199 ? 8.005   -16.534 -23.765 1.00 14.34 ? 199  LEU A C   1 ? 
ATOM   1536 O O   . LEU A 1 199 ? 8.995   -16.168 -23.132 1.00 14.13 ? 199  LEU A O   1 ? 
ATOM   1537 C CB  . LEU A 1 199 ? 5.870   -16.932 -22.512 1.00 17.68 ? 199  LEU A CB  1 ? 
ATOM   1538 C CG  . LEU A 1 199 ? 4.751   -16.313 -21.687 1.00 20.27 ? 199  LEU A CG  1 ? 
ATOM   1539 C CD1 . LEU A 1 199 ? 4.175   -17.370 -20.756 1.00 22.27 ? 199  LEU A CD1 1 ? 
ATOM   1540 C CD2 . LEU A 1 199 ? 5.193   -15.089 -20.897 1.00 21.56 ? 199  LEU A CD2 1 ? 
ATOM   1541 N N   . LEU A 1 200 ? 8.037   -17.478 -24.699 1.00 13.63 ? 200  LEU A N   1 ? 
ATOM   1542 C CA  . LEU A 1 200 ? 9.327   -18.112 -25.056 1.00 14.13 ? 200  LEU A CA  1 ? 
ATOM   1543 C C   . LEU A 1 200 ? 10.249  -17.074 -25.715 1.00 13.33 ? 200  LEU A C   1 ? 
ATOM   1544 O O   . LEU A 1 200 ? 11.458  -17.138 -25.485 1.00 13.22 ? 200  LEU A O   1 ? 
ATOM   1545 C CB  . LEU A 1 200 ? 9.076   -19.321 -25.958 1.00 16.03 ? 200  LEU A CB  1 ? 
ATOM   1546 C CG  . LEU A 1 200 ? 8.405   -20.526 -25.296 1.00 19.61 ? 200  LEU A CG  1 ? 
ATOM   1547 C CD1 . LEU A 1 200 ? 8.125   -21.589 -26.356 1.00 20.78 ? 200  LEU A CD1 1 ? 
ATOM   1548 C CD2 . LEU A 1 200 ? 9.265   -21.106 -24.172 1.00 20.84 ? 200  LEU A CD2 1 ? 
ATOM   1549 N N   . ARG A 1 201 ? 9.712   -16.123 -26.470 1.00 13.02 ? 201  ARG A N   1 ? 
ATOM   1550 C CA  . ARG A 1 201 ? 10.484  -15.016 -27.095 1.00 13.70 ? 201  ARG A CA  1 ? 
ATOM   1551 C C   . ARG A 1 201 ? 11.216  -14.222 -26.007 1.00 12.82 ? 201  ARG A C   1 ? 
ATOM   1552 O O   . ARG A 1 201 ? 12.428  -13.986 -26.104 1.00 12.15 ? 201  ARG A O   1 ? 
ATOM   1553 C CB  . ARG A 1 201 ? 9.507   -14.153 -27.894 1.00 15.45 ? 201  ARG A CB  1 ? 
ATOM   1554 C CG  . ARG A 1 201 ? 10.090  -12.925 -28.575 1.00 17.87 ? 201  ARG A CG  1 ? 
ATOM   1555 C CD  . ARG A 1 201 ? 8.973   -12.099 -29.188 1.00 21.60 ? 201  ARG A CD  1 ? 
ATOM   1556 N NE  . ARG A 1 201 ? 9.400   -10.865 -29.854 1.00 24.60 ? 201  ARG A NE  1 ? 
ATOM   1557 C CZ  . ARG A 1 201 ? 8.583   -9.841  -30.160 1.00 26.68 ? 201  ARG A CZ  1 ? 
ATOM   1558 N NH1 . ARG A 1 201 ? 7.302   -9.860  -29.806 1.00 28.60 ? 201  ARG A NH1 1 ? 
ATOM   1559 N NH2 . ARG A 1 201 ? 9.060   -8.767  -30.783 1.00 26.67 ? 201  ARG A NH2 1 ? 
ATOM   1560 N N   . MET A 1 202 ? 10.487  -13.827 -24.974 1.00 12.33 ? 202  MET A N   1 ? 
ATOM   1561 C CA  . MET A 1 202 ? 11.042  -13.020 -23.887 1.00 12.90 ? 202  MET A CA  1 ? 
ATOM   1562 C C   . MET A 1 202 ? 11.961  -13.877 -23.016 1.00 11.43 ? 202  MET A C   1 ? 
ATOM   1563 O O   . MET A 1 202 ? 13.019  -13.388 -22.597 1.00 11.67 ? 202  MET A O   1 ? 
ATOM   1564 C CB  . MET A 1 202 ? 9.892   -12.410 -23.087 1.00 13.85 ? 202  MET A CB  1 ? 
ATOM   1565 C CG  . MET A 1 202 ? 9.204   -11.346 -23.908 1.00 15.40 ? 202  MET A CG  1 ? 
ATOM   1566 S SD  . MET A 1 202 ? 7.922   -10.450 -23.061 1.00 18.69 ? 202  MET A SD  1 ? 
ATOM   1567 C CE  . MET A 1 202 ? 6.853   -11.786 -22.576 1.00 19.25 ? 202  MET A CE  1 ? 
ATOM   1568 N N   . ALA A 1 203 ? 11.600  -15.124 -22.756 1.00 11.53 ? 203  ALA A N   1 ? 
ATOM   1569 C CA  . ALA A 1 203 ? 12.467  -16.037 -21.977 1.00 11.28 ? 203  ALA A CA  1 ? 
ATOM   1570 C C   . ALA A 1 203 ? 13.827  -16.171 -22.664 1.00 12.46 ? 203  ALA A C   1 ? 
ATOM   1571 O O   . ALA A 1 203 ? 14.849  -16.179 -22.001 1.00 12.71 ? 203  ALA A O   1 ? 
ATOM   1572 C CB  . ALA A 1 203 ? 11.833  -17.381 -21.792 1.00 12.33 ? 203  ALA A CB  1 ? 
ATOM   1573 N N   . SER A 1 204 ? 13.840  -16.264 -23.989 1.00 11.62 ? 204  SER A N   1 ? 
ATOM   1574 C CA  . SER A 1 204 ? 15.107  -16.389 -24.750 1.00 12.54 ? 204  SER A CA  1 ? 
ATOM   1575 C C   . SER A 1 204 ? 15.971  -15.147 -24.523 1.00 11.75 ? 204  SER A C   1 ? 
ATOM   1576 O O   . SER A 1 204 ? 17.201  -15.267 -24.338 1.00 12.02 ? 204  SER A O   1 ? 
ATOM   1577 C CB  . SER A 1 204 ? 14.824  -16.597 -26.220 1.00 13.61 ? 204  SER A CB  1 ? 
ATOM   1578 O OG  . SER A 1 204 ? 15.985  -16.298 -27.018 1.00 15.16 ? 204  SER A OG  1 ? 
ATOM   1579 N N   . MET A 1 205 ? 15.368  -13.958 -24.571 1.00 11.56 ? 205  MET A N   1 ? 
ATOM   1580 C CA  . MET A 1 205 ? 16.074  -12.683 -24.355 1.00 11.92 ? 205  MET A CA  1 ? 
ATOM   1581 C C   . MET A 1 205 ? 16.664  -12.647 -22.941 1.00 11.72 ? 205  MET A C   1 ? 
ATOM   1582 O O   . MET A 1 205 ? 17.806  -12.204 -22.744 1.00 11.98 ? 205  MET A O   1 ? 
ATOM   1583 C CB  . MET A 1 205 ? 15.123  -11.506 -24.581 1.00 12.67 ? 205  MET A CB  1 ? 
ATOM   1584 C CG  . MET A 1 205 ? 14.702  -11.406 -26.012 1.00 12.81 ? 205  MET A CG  1 ? 
ATOM   1585 S SD  . MET A 1 205 ? 13.405  -10.188 -26.228 1.00 14.94 ? 205  MET A SD  1 ? 
ATOM   1586 C CE  . MET A 1 205 ? 13.128  -10.398 -27.988 1.00 15.91 ? 205  MET A CE  1 ? 
ATOM   1587 N N   . TYR A 1 206 ? 15.911  -13.105 -21.947 1.00 11.62 ? 206  TYR A N   1 ? 
ATOM   1588 C CA  . TYR A 1 206 ? 16.332  -13.049 -20.531 1.00 11.60 ? 206  TYR A CA  1 ? 
ATOM   1589 C C   . TYR A 1 206 ? 17.414  -14.096 -20.250 1.00 12.01 ? 206  TYR A C   1 ? 
ATOM   1590 O O   . TYR A 1 206 ? 18.380  -13.791 -19.541 1.00 12.28 ? 206  TYR A O   1 ? 
ATOM   1591 C CB  . TYR A 1 206 ? 15.099  -13.230 -19.650 1.00 10.89 ? 206  TYR A CB  1 ? 
ATOM   1592 C CG  . TYR A 1 206 ? 15.345  -13.063 -18.169 1.00 10.85 ? 206  TYR A CG  1 ? 
ATOM   1593 C CD1 . TYR A 1 206 ? 15.994  -11.953 -17.660 1.00 10.71 ? 206  TYR A CD1 1 ? 
ATOM   1594 C CD2 . TYR A 1 206 ? 14.917  -14.031 -17.279 1.00 11.39 ? 206  TYR A CD2 1 ? 
ATOM   1595 C CE1 . TYR A 1 206 ? 16.196  -11.774 -16.303 1.00 11.09 ? 206  TYR A CE1 1 ? 
ATOM   1596 C CE2 . TYR A 1 206 ? 15.117  -13.886 -15.911 1.00 11.53 ? 206  TYR A CE2 1 ? 
ATOM   1597 C CZ  . TYR A 1 206 ? 15.763  -12.756 -15.427 1.00 11.11 ? 206  TYR A CZ  1 ? 
ATOM   1598 O OH  . TYR A 1 206 ? 16.000  -12.579 -14.086 1.00 13.43 ? 206  TYR A OH  1 ? 
ATOM   1599 N N   . LEU A 1 207 ? 17.264  -15.297 -20.795 1.00 12.22 ? 207  LEU A N   1 ? 
ATOM   1600 C CA  . LEU A 1 207 ? 18.165  -16.436 -20.471 1.00 13.47 ? 207  LEU A CA  1 ? 
ATOM   1601 C C   . LEU A 1 207 ? 19.455  -16.347 -21.274 1.00 15.15 ? 207  LEU A C   1 ? 
ATOM   1602 O O   . LEU A 1 207 ? 20.480  -16.788 -20.756 1.00 15.28 ? 207  LEU A O   1 ? 
ATOM   1603 C CB  . LEU A 1 207 ? 17.466  -17.762 -20.754 1.00 14.04 ? 207  LEU A CB  1 ? 
ATOM   1604 C CG  . LEU A 1 207 ? 16.341  -18.100 -19.785 1.00 14.02 ? 207  LEU A CG  1 ? 
ATOM   1605 C CD1 . LEU A 1 207 ? 15.530  -19.253 -20.336 1.00 14.97 ? 207  LEU A CD1 1 ? 
ATOM   1606 C CD2 . LEU A 1 207 ? 16.910  -18.429 -18.416 1.00 13.72 ? 207  LEU A CD2 1 ? 
ATOM   1607 N N   . ALA A 1 208 ? 19.418  -15.852 -22.503 1.00 15.05 ? 208  ALA A N   1 ? 
ATOM   1608 C CA  . ALA A 1 208 ? 20.636  -15.770 -23.340 1.00 17.20 ? 208  ALA A CA  1 ? 
ATOM   1609 C C   . ALA A 1 208 ? 21.359  -17.128 -23.334 1.00 17.49 ? 208  ALA A C   1 ? 
ATOM   1610 O O   . ALA A 1 208 ? 22.583  -17.166 -23.067 1.00 20.12 ? 208  ALA A O   1 ? 
ATOM   1611 C CB  . ALA A 1 208 ? 21.490  -14.646 -22.820 1.00 17.93 ? 208  ALA A CB  1 ? 
ATOM   1612 N N   . GLY A 1 209 ? 20.618  -18.215 -23.538 1.00 17.63 ? 209  GLY A N   1 ? 
ATOM   1613 C CA  . GLY A 1 209 ? 21.198  -19.566 -23.682 1.00 18.52 ? 209  GLY A CA  1 ? 
ATOM   1614 C C   . GLY A 1 209 ? 21.412  -20.276 -22.355 1.00 18.61 ? 209  GLY A C   1 ? 
ATOM   1615 O O   . GLY A 1 209 ? 21.851  -21.442 -22.378 1.00 18.88 ? 209  GLY A O   1 ? 
ATOM   1616 N N   . GLN A 1 210 ? 21.129  -19.636 -21.214 1.00 15.21 ? 210  GLN A N   1 ? 
ATOM   1617 C CA  . GLN A 1 210 ? 21.233  -20.308 -19.893 1.00 16.61 ? 210  GLN A CA  1 ? 
ATOM   1618 C C   . GLN A 1 210 ? 20.104  -21.324 -19.767 1.00 16.15 ? 210  GLN A C   1 ? 
ATOM   1619 O O   . GLN A 1 210 ? 19.071  -21.182 -20.442 1.00 16.43 ? 210  GLN A O   1 ? 
ATOM   1620 C CB  . GLN A 1 210 ? 21.204  -19.288 -18.752 1.00 16.06 ? 210  GLN A CB  1 ? 
ATOM   1621 C CG  . GLN A 1 210 ? 22.429  -18.414 -18.709 1.00 17.07 ? 210  GLN A CG  1 ? 
ATOM   1622 C CD  . GLN A 1 210 ? 22.262  -17.290 -17.718 1.00 18.66 ? 210  GLN A CD  1 ? 
ATOM   1623 O OE1 . GLN A 1 210 ? 22.579  -17.433 -16.537 1.00 22.87 ? 210  GLN A OE1 1 ? 
ATOM   1624 N NE2 . GLN A 1 210 ? 21.727  -16.176 -18.185 1.00 17.08 ? 210  GLN A NE2 1 ? 
ATOM   1625 N N   . ASP A 1 211 ? 20.311  -22.328 -18.911 1.00 16.62 ? 211  ASP A N   1 ? 
ATOM   1626 C CA  . ASP A 1 211 ? 19.311  -23.375 -18.631 1.00 18.35 ? 211  ASP A CA  1 ? 
ATOM   1627 C C   . ASP A 1 211 ? 17.996  -22.694 -18.265 1.00 17.32 ? 211  ASP A C   1 ? 
ATOM   1628 O O   . ASP A 1 211 ? 17.988  -21.852 -17.372 1.00 17.42 ? 211  ASP A O   1 ? 
ATOM   1629 C CB  . ASP A 1 211 ? 19.815  -24.243 -17.482 1.00 20.42 ? 211  ASP A CB  1 ? 
ATOM   1630 C CG  . ASP A 1 211 ? 18.915  -25.397 -17.079 1.00 25.55 ? 211  ASP A CG  1 ? 
ATOM   1631 O OD1 . ASP A 1 211 ? 17.739  -25.448 -17.517 1.00 25.02 ? 211  ASP A OD1 1 ? 
ATOM   1632 O OD2 . ASP A 1 211 ? 19.416  -26.245 -16.310 1.00 32.03 ? 211  ASP A OD2 1 ? 
ATOM   1633 N N   . PRO A 1 212 ? 16.861  -23.012 -18.914 1.00 17.65 ? 212  PRO A N   1 ? 
ATOM   1634 C CA  . PRO A 1 212 ? 15.601  -22.364 -18.562 1.00 18.10 ? 212  PRO A CA  1 ? 
ATOM   1635 C C   . PRO A 1 212 ? 15.086  -22.768 -17.174 1.00 17.65 ? 212  PRO A C   1 ? 
ATOM   1636 O O   . PRO A 1 212 ? 14.148  -22.154 -16.709 1.00 17.92 ? 212  PRO A O   1 ? 
ATOM   1637 C CB  . PRO A 1 212 ? 14.618  -22.813 -19.651 1.00 19.70 ? 212  PRO A CB  1 ? 
ATOM   1638 C CG  . PRO A 1 212 ? 15.221  -24.080 -20.213 1.00 20.71 ? 212  PRO A CG  1 ? 
ATOM   1639 C CD  . PRO A 1 212 ? 16.718  -23.919 -20.069 1.00 19.01 ? 212  PRO A CD  1 ? 
ATOM   1640 N N   . ARG A 1 213 ? 15.713  -23.751 -16.523 1.00 16.17 ? 213  ARG A N   1 ? 
ATOM   1641 C CA  . ARG A 1 213 ? 15.376  -24.130 -15.129 1.00 17.85 ? 213  ARG A CA  1 ? 
ATOM   1642 C C   . ARG A 1 213 ? 16.377  -23.539 -14.133 1.00 17.60 ? 213  ARG A C   1 ? 
ATOM   1643 O O   . ARG A 1 213 ? 16.370  -23.949 -12.959 1.00 18.91 ? 213  ARG A O   1 ? 
ATOM   1644 C CB  . ARG A 1 213 ? 15.264  -25.649 -15.048 1.00 18.08 ? 213  ARG A CB  1 ? 
ATOM   1645 C CG  . ARG A 1 213 ? 14.170  -26.177 -15.958 1.00 19.66 ? 213  ARG A CG  1 ? 
ATOM   1646 C CD  . ARG A 1 213 ? 13.862  -27.622 -15.717 1.00 21.95 ? 213  ARG A CD  1 ? 
ATOM   1647 N NE  . ARG A 1 213 ? 12.788  -28.007 -16.602 1.00 21.91 ? 213  ARG A NE  1 ? 
ATOM   1648 C CZ  . ARG A 1 213 ? 11.991  -29.053 -16.415 1.00 26.42 ? 213  ARG A CZ  1 ? 
ATOM   1649 N NH1 . ARG A 1 213 ? 12.146  -29.856 -15.373 1.00 27.12 ? 213  ARG A NH1 1 ? 
ATOM   1650 N NH2 . ARG A 1 213 ? 11.058  -29.313 -17.306 1.00 27.81 ? 213  ARG A NH2 1 ? 
ATOM   1651 N N   . THR A 1 214 ? 17.229  -22.601 -14.561 1.00 16.19 ? 214  THR A N   1 ? 
ATOM   1652 C CA  . THR A 1 214 ? 18.135  -21.843 -13.674 1.00 16.76 ? 214  THR A CA  1 ? 
ATOM   1653 C C   . THR A 1 214 ? 17.299  -21.289 -12.523 1.00 16.62 ? 214  THR A C   1 ? 
ATOM   1654 O O   . THR A 1 214 ? 16.350  -20.552 -12.782 1.00 15.24 ? 214  THR A O   1 ? 
ATOM   1655 C CB  . THR A 1 214 ? 18.817  -20.701 -14.439 1.00 17.67 ? 214  THR A CB  1 ? 
ATOM   1656 O OG1 . THR A 1 214 ? 19.717  -21.249 -15.412 1.00 18.65 ? 214  THR A OG1 1 ? 
ATOM   1657 C CG2 . THR A 1 214 ? 19.579  -19.765 -13.537 1.00 17.55 ? 214  THR A CG2 1 ? 
ATOM   1658 N N   . PRO A 1 215 ? 17.561  -21.662 -11.254 1.00 15.67 ? 215  PRO A N   1 ? 
ATOM   1659 C CA  . PRO A 1 215 ? 16.622  -21.361 -10.172 1.00 15.27 ? 215  PRO A CA  1 ? 
ATOM   1660 C C   . PRO A 1 215 ? 16.306  -19.875 -9.922  1.00 14.89 ? 215  PRO A C   1 ? 
ATOM   1661 O O   . PRO A 1 215 ? 15.163  -19.562 -9.628  1.00 15.36 ? 215  PRO A O   1 ? 
ATOM   1662 C CB  . PRO A 1 215 ? 17.289  -21.946 -8.919  1.00 17.04 ? 215  PRO A CB  1 ? 
ATOM   1663 C CG  . PRO A 1 215 ? 18.200  -23.031 -9.467  1.00 18.48 ? 215  PRO A CG  1 ? 
ATOM   1664 C CD  . PRO A 1 215 ? 18.638  -22.573 -10.832 1.00 17.15 ? 215  PRO A CD  1 ? 
ATOM   1665 N N   . LEU A 1 216 ? 17.260  -18.962 -10.067 1.00 13.75 ? 216  LEU A N   1 ? 
ATOM   1666 C CA  . LEU A 1 216 ? 16.951  -17.526 -9.852  1.00 13.32 ? 216  LEU A CA  1 ? 
ATOM   1667 C C   . LEU A 1 216 ? 16.283  -16.928 -11.097 1.00 12.82 ? 216  LEU A C   1 ? 
ATOM   1668 O O   . LEU A 1 216 ? 15.803  -15.779 -10.972 1.00 14.09 ? 216  LEU A O   1 ? 
ATOM   1669 C CB  . LEU A 1 216 ? 18.203  -16.729 -9.477  1.00 14.11 ? 216  LEU A CB  1 ? 
ATOM   1670 C CG  . LEU A 1 216 ? 18.813  -17.074 -8.119  1.00 14.76 ? 216  LEU A CG  1 ? 
ATOM   1671 C CD1 . LEU A 1 216 ? 20.014  -16.184 -7.849  1.00 15.98 ? 216  LEU A CD1 1 ? 
ATOM   1672 C CD2 . LEU A 1 216 ? 17.780  -16.914 -7.023  1.00 15.65 ? 216  LEU A CD2 1 ? 
ATOM   1673 N N   . ALA A 1 217 ? 16.226  -17.633 -12.234 1.00 12.91 ? 217  ALA A N   1 ? 
ATOM   1674 C CA  . ALA A 1 217 ? 15.482  -17.143 -13.416 1.00 13.56 ? 217  ALA A CA  1 ? 
ATOM   1675 C C   . ALA A 1 217 ? 14.073  -17.734 -13.376 1.00 13.48 ? 217  ALA A C   1 ? 
ATOM   1676 O O   . ALA A 1 217 ? 13.121  -17.072 -13.817 1.00 13.63 ? 217  ALA A O   1 ? 
ATOM   1677 C CB  . ALA A 1 217 ? 16.197  -17.498 -14.691 1.00 14.04 ? 217  ALA A CB  1 ? 
ATOM   1678 N N   . ALA A 1 218 ? 13.965  -18.963 -12.871 1.00 13.64 ? 218  ALA A N   1 ? 
ATOM   1679 C CA  . ALA A 1 218 ? 12.743  -19.785 -12.910 1.00 13.98 ? 218  ALA A CA  1 ? 
ATOM   1680 C C   . ALA A 1 218 ? 12.540  -20.376 -11.527 1.00 14.05 ? 218  ALA A C   1 ? 
ATOM   1681 O O   . ALA A 1 218 ? 12.926  -21.505 -11.256 1.00 14.31 ? 218  ALA A O   1 ? 
ATOM   1682 C CB  . ALA A 1 218 ? 12.848  -20.858 -13.965 1.00 14.52 ? 218  ALA A CB  1 ? 
ATOM   1683 N N   . PRO A 1 219 ? 12.002  -19.589 -10.578 1.00 13.81 ? 219  PRO A N   1 ? 
ATOM   1684 C CA  . PRO A 1 219 ? 11.997  -20.009 -9.182  1.00 14.23 ? 219  PRO A CA  1 ? 
ATOM   1685 C C   . PRO A 1 219 ? 11.070  -21.176 -8.827  1.00 14.32 ? 219  PRO A C   1 ? 
ATOM   1686 O O   . PRO A 1 219 ? 11.116  -21.623 -7.695  1.00 14.15 ? 219  PRO A O   1 ? 
ATOM   1687 C CB  . PRO A 1 219 ? 11.596  -18.763 -8.381  1.00 15.77 ? 219  PRO A CB  1 ? 
ATOM   1688 C CG  . PRO A 1 219 ? 11.392  -17.655 -9.372  1.00 15.71 ? 219  PRO A CG  1 ? 
ATOM   1689 C CD  . PRO A 1 219 ? 11.650  -18.183 -10.760 1.00 14.35 ? 219  PRO A CD  1 ? 
ATOM   1690 N N   . LEU A 1 220 ? 10.341  -21.723 -9.803  1.00 14.31 ? 220  LEU A N   1 ? 
ATOM   1691 C CA  . LEU A 1 220 ? 9.699   -23.036 -9.634  1.00 16.88 ? 220  LEU A CA  1 ? 
ATOM   1692 C C   . LEU A 1 220 ? 10.771  -24.076 -9.299  1.00 16.00 ? 220  LEU A C   1 ? 
ATOM   1693 O O   . LEU A 1 220 ? 10.415  -25.087 -8.706  1.00 21.31 ? 220  LEU A O   1 ? 
ATOM   1694 C CB  . LEU A 1 220 ? 8.984   -23.391 -10.932 1.00 19.67 ? 220  LEU A CB  1 ? 
ATOM   1695 C CG  . LEU A 1 220 ? 8.174   -24.679 -10.891 1.00 22.32 ? 220  LEU A CG  1 ? 
ATOM   1696 C CD1 . LEU A 1 220 ? 7.170   -24.646 -9.741  1.00 25.02 ? 220  LEU A CD1 1 ? 
ATOM   1697 C CD2 . LEU A 1 220 ? 7.483   -24.865 -12.239 1.00 24.18 ? 220  LEU A CD2 1 ? 
ATOM   1698 N N   . TYR A 1 221 ? 12.039  -23.825 -9.639  1.00 14.31 ? 221  TYR A N   1 ? 
ATOM   1699 C CA  . TYR A 1 221 ? 13.148  -24.789 -9.416  1.00 16.10 ? 221  TYR A CA  1 ? 
ATOM   1700 C C   . TYR A 1 221 ? 14.064  -24.329 -8.286  1.00 16.11 ? 221  TYR A C   1 ? 
ATOM   1701 O O   . TYR A 1 221 ? 15.121  -24.978 -8.066  1.00 17.82 ? 221  TYR A O   1 ? 
ATOM   1702 C CB  . TYR A 1 221 ? 13.894  -25.012 -10.727 1.00 15.87 ? 221  TYR A CB  1 ? 
ATOM   1703 C CG  . TYR A 1 221 ? 12.960  -25.492 -11.799 1.00 17.33 ? 221  TYR A CG  1 ? 
ATOM   1704 C CD1 . TYR A 1 221 ? 12.479  -26.793 -11.777 1.00 19.37 ? 221  TYR A CD1 1 ? 
ATOM   1705 C CD2 . TYR A 1 221 ? 12.424  -24.636 -12.747 1.00 17.09 ? 221  TYR A CD2 1 ? 
ATOM   1706 C CE1 . TYR A 1 221 ? 11.573  -27.253 -12.716 1.00 19.79 ? 221  TYR A CE1 1 ? 
ATOM   1707 C CE2 . TYR A 1 221 ? 11.506  -25.073 -13.683 1.00 18.19 ? 221  TYR A CE2 1 ? 
ATOM   1708 C CZ  . TYR A 1 221 ? 11.086  -26.392 -13.685 1.00 19.94 ? 221  TYR A CZ  1 ? 
ATOM   1709 O OH  . TYR A 1 221 ? 10.177  -26.801 -14.618 1.00 21.92 ? 221  TYR A OH  1 ? 
ATOM   1710 N N   . ALA A 1 222 ? 13.700  -23.271 -7.567  1.00 14.45 ? 222  ALA A N   1 ? 
ATOM   1711 C CA  . ALA A 1 222 ? 14.517  -22.731 -6.466  1.00 14.41 ? 222  ALA A CA  1 ? 
ATOM   1712 C C   . ALA A 1 222 ? 14.147  -23.402 -5.147  1.00 14.25 ? 222  ALA A C   1 ? 
ATOM   1713 O O   . ALA A 1 222 ? 13.055  -23.968 -4.989  1.00 13.92 ? 222  ALA A O   1 ? 
ATOM   1714 C CB  . ALA A 1 222 ? 14.364  -21.231 -6.365  1.00 15.80 ? 222  ALA A CB  1 ? 
ATOM   1715 N N   . ASP A 1 223 ? 15.067  -23.321 -4.203  1.00 13.66 ? 223  ASP A N   1 ? 
ATOM   1716 C CA  . ASP A 1 223 ? 14.820  -23.750 -2.810  1.00 14.02 ? 223  ASP A CA  1 ? 
ATOM   1717 C C   . ASP A 1 223 ? 14.089  -22.631 -2.084  1.00 12.49 ? 223  ASP A C   1 ? 
ATOM   1718 O O   . ASP A 1 223 ? 14.669  -21.582 -1.930  1.00 12.86 ? 223  ASP A O   1 ? 
ATOM   1719 C CB  . ASP A 1 223 ? 16.159  -24.059 -2.146  1.00 14.49 ? 223  ASP A CB  1 ? 
ATOM   1720 C CG  . ASP A 1 223 ? 16.053  -24.711 -0.793  1.00 16.79 ? 223  ASP A CG  1 ? 
ATOM   1721 O OD1 . ASP A 1 223 ? 15.033  -24.550 -0.110  1.00 17.19 ? 223  ASP A OD1 1 ? 
ATOM   1722 O OD2 . ASP A 1 223 ? 17.015  -25.420 -0.449  1.00 18.27 ? 223  ASP A OD2 1 ? 
ATOM   1723 N N   . LEU A 1 224 ? 12.827  -22.845 -1.702  1.00 12.82 ? 224  LEU A N   1 ? 
ATOM   1724 C CA  . LEU A 1 224 ? 11.979  -21.756 -1.138  1.00 12.33 ? 224  LEU A CA  1 ? 
ATOM   1725 C C   . LEU A 1 224 ? 11.907  -21.809 0.395   1.00 12.79 ? 224  LEU A C   1 ? 
ATOM   1726 O O   . LEU A 1 224 ? 11.186  -21.023 0.976   1.00 13.32 ? 224  LEU A O   1 ? 
ATOM   1727 C CB  . LEU A 1 224 ? 10.576  -21.852 -1.750  1.00 12.24 ? 224  LEU A CB  1 ? 
ATOM   1728 C CG  . LEU A 1 224 ? 10.545  -21.796 -3.274  1.00 12.85 ? 224  LEU A CG  1 ? 
ATOM   1729 C CD1 . LEU A 1 224 ? 9.116   -21.752 -3.792  1.00 13.14 ? 224  LEU A CD1 1 ? 
ATOM   1730 C CD2 . LEU A 1 224 ? 11.284  -20.597 -3.814  1.00 13.26 ? 224  LEU A CD2 1 ? 
ATOM   1731 N N   . ARG A 1 225 ? 12.654  -22.701 1.045   1.00 13.47 ? 225  ARG A N   1 ? 
ATOM   1732 C CA  . ARG A 1 225 ? 12.583  -22.824 2.512   1.00 14.47 ? 225  ARG A CA  1 ? 
ATOM   1733 C C   . ARG A 1 225 ? 12.944  -21.492 3.169   1.00 13.75 ? 225  ARG A C   1 ? 
ATOM   1734 O O   . ARG A 1 225 ? 13.926  -20.837 2.754   1.00 15.41 ? 225  ARG A O   1 ? 
ATOM   1735 C CB  . ARG A 1 225 ? 13.457  -23.972 3.017   1.00 16.97 ? 225  ARG A CB  1 ? 
ATOM   1736 C CG  . ARG A 1 225 ? 13.156  -24.286 4.471   1.00 20.80 ? 225  ARG A CG  1 ? 
ATOM   1737 C CD  . ARG A 1 225 ? 13.357  -25.728 4.848   1.00 21.34 ? 225  ARG A CD  1 ? 
ATOM   1738 N NE  . ARG A 1 225 ? 12.604  -26.744 4.136   1.00 21.72 ? 225  ARG A NE  1 ? 
ATOM   1739 C CZ  . ARG A 1 225 ? 11.468  -27.277 4.552   1.00 21.50 ? 225  ARG A CZ  1 ? 
ATOM   1740 N NH1 . ARG A 1 225 ? 10.917  -28.245 3.845   1.00 27.13 ? 225  ARG A NH1 1 ? 
ATOM   1741 N NH2 . ARG A 1 225 ? 10.879  -26.826 5.640   1.00 22.38 ? 225  ARG A NH2 1 ? 
ATOM   1742 N N   . GLY A 1 226 ? 12.161  -21.077 4.157   1.00 14.15 ? 226  GLY A N   1 ? 
ATOM   1743 C CA  . GLY A 1 226 ? 12.481  -19.905 4.973   1.00 13.76 ? 226  GLY A CA  1 ? 
ATOM   1744 C C   . GLY A 1 226 ? 11.874  -18.615 4.442   1.00 13.60 ? 226  GLY A C   1 ? 
ATOM   1745 O O   . GLY A 1 226 ? 12.020  -17.577 5.130   1.00 15.60 ? 226  GLY A O   1 ? 
ATOM   1746 N N   . LEU A 1 227 ? 11.180  -18.662 3.314   1.00 13.19 ? 227  LEU A N   1 ? 
ATOM   1747 C CA  . LEU A 1 227 ? 10.542  -17.430 2.777   1.00 13.86 ? 227  LEU A CA  1 ? 
ATOM   1748 C C   . LEU A 1 227 ? 9.427   -16.976 3.704   1.00 13.73 ? 227  LEU A C   1 ? 
ATOM   1749 O O   . LEU A 1 227 ? 8.803   -17.776 4.405   1.00 13.99 ? 227  LEU A O   1 ? 
ATOM   1750 C CB  . LEU A 1 227 ? 10.018  -17.678 1.365   1.00 13.85 ? 227  LEU A CB  1 ? 
ATOM   1751 C CG  . LEU A 1 227 ? 10.944  -17.150 0.278   1.00 15.83 ? 227  LEU A CG  1 ? 
ATOM   1752 C CD1 . LEU A 1 227 ? 12.344  -17.715 0.447   1.00 16.45 ? 227  LEU A CD1 1 ? 
ATOM   1753 C CD2 . LEU A 1 227 ? 10.359  -17.422 -1.104  1.00 15.98 ? 227  LEU A CD2 1 ? 
ATOM   1754 N N   . PRO A 1 228 ? 9.143   -15.664 3.716   1.00 13.69 ? 228  PRO A N   1 ? 
ATOM   1755 C CA  . PRO A 1 228 ? 8.076   -15.116 4.541   1.00 13.59 ? 228  PRO A CA  1 ? 
ATOM   1756 C C   . PRO A 1 228 ? 6.718   -15.396 3.922   1.00 13.60 ? 228  PRO A C   1 ? 
ATOM   1757 O O   . PRO A 1 228 ? 6.629   -15.909 2.806   1.00 12.38 ? 228  PRO A O   1 ? 
ATOM   1758 C CB  . PRO A 1 228 ? 8.421   -13.624 4.581   1.00 14.33 ? 228  PRO A CB  1 ? 
ATOM   1759 C CG  . PRO A 1 228 ? 9.029   -13.367 3.243   1.00 14.55 ? 228  PRO A CG  1 ? 
ATOM   1760 C CD  . PRO A 1 228 ? 9.795   -14.627 2.899   1.00 14.32 ? 228  PRO A CD  1 ? 
ATOM   1761 N N   . PRO A 1 229 ? 5.630   -15.052 4.636   1.00 12.76 ? 229  PRO A N   1 ? 
ATOM   1762 C CA  . PRO A 1 229 ? 4.289   -15.286 4.118   1.00 12.75 ? 229  PRO A CA  1 ? 
ATOM   1763 C C   . PRO A 1 229 ? 4.095   -14.648 2.740   1.00 12.32 ? 229  PRO A C   1 ? 
ATOM   1764 O O   . PRO A 1 229 ? 4.509   -13.485 2.535   1.00 12.77 ? 229  PRO A O   1 ? 
ATOM   1765 C CB  . PRO A 1 229 ? 3.375   -14.632 5.139   1.00 13.49 ? 229  PRO A CB  1 ? 
ATOM   1766 C CG  . PRO A 1 229 ? 4.165   -14.705 6.414   1.00 14.34 ? 229  PRO A CG  1 ? 
ATOM   1767 C CD  . PRO A 1 229 ? 5.610   -14.516 6.003   1.00 14.17 ? 229  PRO A CD  1 ? 
ATOM   1768 N N   A LEU A 1 230 ? 3.544   -15.448 1.819   0.50 11.60 ? 230  LEU A N   1 ? 
ATOM   1769 N N   B LEU A 1 230 ? 3.438   -15.390 1.861   0.50 11.83 ? 230  LEU A N   1 ? 
ATOM   1770 C CA  A LEU A 1 230 ? 3.315   -15.072 0.402   0.50 11.47 ? 230  LEU A CA  1 ? 
ATOM   1771 C CA  B LEU A 1 230 ? 3.360   -15.079 0.419   0.50 11.93 ? 230  LEU A CA  1 ? 
ATOM   1772 C C   A LEU A 1 230 ? 1.807   -14.967 0.166   0.50 11.04 ? 230  LEU A C   1 ? 
ATOM   1773 C C   B LEU A 1 230 ? 1.896   -15.063 -0.029  0.50 11.36 ? 230  LEU A C   1 ? 
ATOM   1774 O O   A LEU A 1 230 ? 1.020   -15.812 0.693   0.50 11.26 ? 230  LEU A O   1 ? 
ATOM   1775 O O   B LEU A 1 230 ? 1.237   -16.125 0.048   0.50 11.75 ? 230  LEU A O   1 ? 
ATOM   1776 C CB  A LEU A 1 230 ? 3.915   -16.090 -0.577  0.50 11.58 ? 230  LEU A CB  1 ? 
ATOM   1777 C CB  B LEU A 1 230 ? 4.183   -16.159 -0.284  0.50 12.50 ? 230  LEU A CB  1 ? 
ATOM   1778 C CG  A LEU A 1 230 ? 5.390   -16.451 -0.408  0.50 11.84 ? 230  LEU A CG  1 ? 
ATOM   1779 C CG  B LEU A 1 230 ? 4.211   -16.092 -1.801  0.50 12.90 ? 230  LEU A CG  1 ? 
ATOM   1780 C CD1 A LEU A 1 230 ? 5.812   -17.468 -1.465  0.50 11.82 ? 230  LEU A CD1 1 ? 
ATOM   1781 C CD1 B LEU A 1 230 ? 4.758   -14.748 -2.261  0.50 13.85 ? 230  LEU A CD1 1 ? 
ATOM   1782 C CD2 A LEU A 1 230 ? 6.274   -15.211 -0.465  0.50 12.19 ? 230  LEU A CD2 1 ? 
ATOM   1783 C CD2 B LEU A 1 230 ? 5.027   -17.240 -2.368  0.50 13.47 ? 230  LEU A CD2 1 ? 
ATOM   1784 N N   . LEU A 1 231 ? 1.425   -13.929 -0.562  1.00 10.80 ? 231  LEU A N   1 ? 
ATOM   1785 C CA  . LEU A 1 231 ? 0.102   -13.827 -1.204  1.00 11.12 ? 231  LEU A CA  1 ? 
ATOM   1786 C C   . LEU A 1 231 ? 0.358   -13.990 -2.695  1.00 11.33 ? 231  LEU A C   1 ? 
ATOM   1787 O O   . LEU A 1 231 ? 1.115   -13.197 -3.259  1.00 11.66 ? 231  LEU A O   1 ? 
ATOM   1788 C CB  . LEU A 1 231 ? -0.551  -12.481 -0.902  1.00 12.00 ? 231  LEU A CB  1 ? 
ATOM   1789 C CG  . LEU A 1 231 ? -1.850  -12.216 -1.661  1.00 12.96 ? 231  LEU A CG  1 ? 
ATOM   1790 C CD1 . LEU A 1 231 ? -2.922  -13.242 -1.319  1.00 14.01 ? 231  LEU A CD1 1 ? 
ATOM   1791 C CD2 . LEU A 1 231 ? -2.343  -10.807 -1.386  1.00 12.88 ? 231  LEU A CD2 1 ? 
ATOM   1792 N N   . ILE A 1 232 ? -0.298  -14.943 -3.320  1.00 10.94 ? 232  ILE A N   1 ? 
ATOM   1793 C CA  . ILE A 1 232 ? -0.263  -15.128 -4.791  1.00 10.83 ? 232  ILE A CA  1 ? 
ATOM   1794 C C   . ILE A 1 232 ? -1.679  -14.845 -5.290  1.00 11.83 ? 232  ILE A C   1 ? 
ATOM   1795 O O   . ILE A 1 232 ? -2.568  -15.640 -4.969  1.00 11.80 ? 232  ILE A O   1 ? 
ATOM   1796 C CB  . ILE A 1 232 ? 0.201   -16.536 -5.182  1.00 11.19 ? 232  ILE A CB  1 ? 
ATOM   1797 C CG1 . ILE A 1 232 ? 1.551   -16.891 -4.561  1.00 12.39 ? 232  ILE A CG1 1 ? 
ATOM   1798 C CG2 . ILE A 1 232 ? 0.231   -16.648 -6.701  1.00 11.09 ? 232  ILE A CG2 1 ? 
ATOM   1799 C CD1 . ILE A 1 232 ? 1.862   -18.374 -4.597  1.00 13.44 ? 232  ILE A CD1 1 ? 
ATOM   1800 N N   . GLN A 1 233 ? -1.859  -13.807 -6.092  1.00 11.01 ? 233  GLN A N   1 ? 
ATOM   1801 C CA  . GLN A 1 233 ? -3.162  -13.517 -6.736  1.00 12.11 ? 233  GLN A CA  1 ? 
ATOM   1802 C C   . GLN A 1 233 ? -3.021  -13.863 -8.209  1.00 12.56 ? 233  GLN A C   1 ? 
ATOM   1803 O O   . GLN A 1 233 ? -2.027  -13.456 -8.813  1.00 13.96 ? 233  GLN A O   1 ? 
ATOM   1804 C CB  . GLN A 1 233 ? -3.570  -12.049 -6.644  1.00 12.56 ? 233  GLN A CB  1 ? 
ATOM   1805 C CG  . GLN A 1 233 ? -3.962  -11.605 -5.256  1.00 13.10 ? 233  GLN A CG  1 ? 
ATOM   1806 C CD  . GLN A 1 233 ? -4.486  -10.191 -5.220  1.00 13.41 ? 233  GLN A CD  1 ? 
ATOM   1807 O OE1 . GLN A 1 233 ? -4.139  -9.334  -6.038  1.00 13.31 ? 233  GLN A OE1 1 ? 
ATOM   1808 N NE2 . GLN A 1 233 ? -5.320  -9.920  -4.230  1.00 12.59 ? 233  GLN A NE2 1 ? 
ATOM   1809 N N   . VAL A 1 234 ? -3.956  -14.608 -8.767  1.00 12.11 ? 234  VAL A N   1 ? 
ATOM   1810 C CA  . VAL A 1 234 ? -3.878  -15.069 -10.171 1.00 12.02 ? 234  VAL A CA  1 ? 
ATOM   1811 C C   . VAL A 1 234 ? -5.291  -15.179 -10.721 1.00 13.43 ? 234  VAL A C   1 ? 
ATOM   1812 O O   . VAL A 1 234 ? -6.216  -15.394 -9.924  1.00 13.46 ? 234  VAL A O   1 ? 
ATOM   1813 C CB  . VAL A 1 234 ? -3.119  -16.403 -10.280 1.00 12.15 ? 234  VAL A CB  1 ? 
ATOM   1814 C CG1 . VAL A 1 234 ? -3.865  -17.508 -9.519  1.00 12.45 ? 234  VAL A CG1 1 ? 
ATOM   1815 C CG2 . VAL A 1 234 ? -2.845  -16.784 -11.728 1.00 12.25 ? 234  VAL A CG2 1 ? 
ATOM   1816 N N   . GLY A 1 235 ? -5.464  -14.920 -12.003 1.00 12.26 ? 235  GLY A N   1 ? 
ATOM   1817 C CA  . GLY A 1 235 ? -6.786  -15.045 -12.640 1.00 13.82 ? 235  GLY A CA  1 ? 
ATOM   1818 C C   . GLY A 1 235 ? -6.962  -16.421 -13.233 1.00 13.83 ? 235  GLY A C   1 ? 
ATOM   1819 O O   . GLY A 1 235 ? -5.993  -17.058 -13.673 1.00 14.83 ? 235  GLY A O   1 ? 
ATOM   1820 N N   . THR A 1 236 ? -8.197  -16.912 -13.323 1.00 15.95 ? 236  THR A N   1 ? 
ATOM   1821 C CA  . THR A 1 236 ? -8.423  -18.266 -13.875 1.00 16.84 ? 236  THR A CA  1 ? 
ATOM   1822 C C   . THR A 1 236 ? -8.457  -18.204 -15.408 1.00 16.09 ? 236  THR A C   1 ? 
ATOM   1823 O O   . THR A 1 236 ? -8.369  -19.282 -16.027 1.00 19.52 ? 236  THR A O   1 ? 
ATOM   1824 C CB  . THR A 1 236 ? -9.659  -18.939 -13.269 1.00 19.43 ? 236  THR A CB  1 ? 
ATOM   1825 O OG1 . THR A 1 236 ? -10.807 -18.253 -13.750 1.00 19.29 ? 236  THR A OG1 1 ? 
ATOM   1826 C CG2 . THR A 1 236 ? -9.654  -18.932 -11.757 1.00 20.73 ? 236  THR A CG2 1 ? 
ATOM   1827 N N   . ALA A 1 237 ? -8.548  -17.012 -16.004 1.00 16.67 ? 237  ALA A N   1 ? 
ATOM   1828 C CA  . ALA A 1 237 ? -8.484  -16.847 -17.481 1.00 17.14 ? 237  ALA A CA  1 ? 
ATOM   1829 C C   . ALA A 1 237 ? -7.055  -16.499 -17.892 1.00 18.12 ? 237  ALA A C   1 ? 
ATOM   1830 O O   . ALA A 1 237 ? -6.840  -15.518 -18.638 1.00 18.02 ? 237  ALA A O   1 ? 
ATOM   1831 C CB  . ALA A 1 237 ? -9.450  -15.806 -17.952 1.00 17.19 ? 237  ALA A CB  1 ? 
ATOM   1832 N N   . GLU A 1 238 ? -6.114  -17.307 -17.424 1.00 16.12 ? 238  GLU A N   1 ? 
ATOM   1833 C CA  . GLU A 1 238 ? -4.663  -17.059 -17.582 1.00 15.45 ? 238  GLU A CA  1 ? 
ATOM   1834 C C   . GLU A 1 238 ? -3.957  -18.334 -18.003 1.00 13.77 ? 238  GLU A C   1 ? 
ATOM   1835 O O   . GLU A 1 238 ? -4.037  -19.378 -17.282 1.00 14.27 ? 238  GLU A O   1 ? 
ATOM   1836 C CB  . GLU A 1 238 ? -4.035  -16.585 -16.273 1.00 14.44 ? 238  GLU A CB  1 ? 
ATOM   1837 C CG  . GLU A 1 238 ? -4.369  -15.167 -15.915 1.00 14.77 ? 238  GLU A CG  1 ? 
ATOM   1838 C CD  . GLU A 1 238 ? -3.284  -14.496 -15.096 1.00 14.76 ? 238  GLU A CD  1 ? 
ATOM   1839 O OE1 . GLU A 1 238 ? -2.151  -14.395 -15.641 1.00 15.83 ? 238  GLU A OE1 1 ? 
ATOM   1840 O OE2 . GLU A 1 238 ? -3.561  -14.057 -13.957 1.00 14.01 ? 238  GLU A OE2 1 ? 
ATOM   1841 N N   . THR A 1 239 ? -3.163  -18.257 -19.067 1.00 13.99 ? 239  THR A N   1 ? 
ATOM   1842 C CA  . THR A 1 239 ? -2.215  -19.333 -19.411 1.00 14.30 ? 239  THR A CA  1 ? 
ATOM   1843 C C   . THR A 1 239 ? -1.201  -19.475 -18.273 1.00 13.39 ? 239  THR A C   1 ? 
ATOM   1844 O O   . THR A 1 239 ? -0.713  -20.581 -18.108 1.00 14.36 ? 239  THR A O   1 ? 
ATOM   1845 C CB  . THR A 1 239 ? -1.518  -19.078 -20.744 1.00 15.67 ? 239  THR A CB  1 ? 
ATOM   1846 O OG1 . THR A 1 239 ? -0.963  -17.761 -20.728 1.00 15.35 ? 239  THR A OG1 1 ? 
ATOM   1847 C CG2 . THR A 1 239 ? -2.468  -19.235 -21.903 1.00 16.37 ? 239  THR A CG2 1 ? 
ATOM   1848 N N   . LEU A 1 240 ? -0.934  -18.415 -17.504 1.00 13.22 ? 240  LEU A N   1 ? 
ATOM   1849 C CA  . LEU A 1 240 ? 0.008   -18.530 -16.357 1.00 13.37 ? 240  LEU A CA  1 ? 
ATOM   1850 C C   . LEU A 1 240 ? -0.676  -19.034 -15.080 1.00 13.67 ? 240  LEU A C   1 ? 
ATOM   1851 O O   . LEU A 1 240 ? -0.016  -19.062 -14.035 1.00 12.49 ? 240  LEU A O   1 ? 
ATOM   1852 C CB  . LEU A 1 240 ? 0.697   -17.184 -16.135 1.00 14.04 ? 240  LEU A CB  1 ? 
ATOM   1853 C CG  . LEU A 1 240 ? 1.685   -16.821 -17.238 1.00 14.27 ? 240  LEU A CG  1 ? 
ATOM   1854 C CD1 . LEU A 1 240 ? 2.144   -15.384 -17.059 1.00 15.24 ? 240  LEU A CD1 1 ? 
ATOM   1855 C CD2 . LEU A 1 240 ? 2.878   -17.769 -17.262 1.00 15.73 ? 240  LEU A CD2 1 ? 
ATOM   1856 N N   . LEU A 1 241 ? -1.931  -19.488 -15.136 1.00 13.28 ? 241  LEU A N   1 ? 
ATOM   1857 C CA  . LEU A 1 241 ? -2.594  -19.983 -13.900 1.00 12.66 ? 241  LEU A CA  1 ? 
ATOM   1858 C C   . LEU A 1 241 ? -1.738  -21.060 -13.231 1.00 13.29 ? 241  LEU A C   1 ? 
ATOM   1859 O O   . LEU A 1 241 ? -1.513  -20.980 -11.992 1.00 12.38 ? 241  LEU A O   1 ? 
ATOM   1860 C CB  . LEU A 1 241 ? -3.984  -20.520 -14.250 1.00 14.11 ? 241  LEU A CB  1 ? 
ATOM   1861 C CG  . LEU A 1 241 ? -4.716  -21.207 -13.101 1.00 14.41 ? 241  LEU A CG  1 ? 
ATOM   1862 C CD1 . LEU A 1 241 ? -4.884  -20.320 -11.899 1.00 15.58 ? 241  LEU A CD1 1 ? 
ATOM   1863 C CD2 . LEU A 1 241 ? -6.081  -21.697 -13.595 1.00 15.95 ? 241  LEU A CD2 1 ? 
ATOM   1864 N N   . ASP A 1 242 ? -1.245  -22.023 -13.993 1.00 13.50 ? 242  ASP A N   1 ? 
ATOM   1865 C CA  . ASP A 1 242 ? -0.506  -23.153 -13.382 1.00 15.33 ? 242  ASP A CA  1 ? 
ATOM   1866 C C   . ASP A 1 242 ? 0.893   -22.724 -12.925 1.00 14.27 ? 242  ASP A C   1 ? 
ATOM   1867 O O   . ASP A 1 242 ? 1.467   -23.450 -12.086 1.00 13.93 ? 242  ASP A O   1 ? 
ATOM   1868 C CB  . ASP A 1 242 ? -0.444  -24.359 -14.309 1.00 17.32 ? 242  ASP A CB  1 ? 
ATOM   1869 C CG  . ASP A 1 242 ? -1.743  -25.137 -14.235 1.00 20.24 ? 242  ASP A CG  1 ? 
ATOM   1870 O OD1 . ASP A 1 242 ? -2.330  -25.201 -13.112 1.00 23.96 ? 242  ASP A OD1 1 ? 
ATOM   1871 O OD2 . ASP A 1 242 ? -2.163  -25.658 -15.277 1.00 20.61 ? 242  ASP A OD2 1 ? 
ATOM   1872 N N   . ASP A 1 243 ? 1.410   -21.567 -13.354 1.00 14.27 ? 243  ASP A N   1 ? 
ATOM   1873 C CA  . ASP A 1 243 ? 2.627   -21.011 -12.707 1.00 13.11 ? 243  ASP A CA  1 ? 
ATOM   1874 C C   . ASP A 1 243 ? 2.331   -20.724 -11.236 1.00 12.54 ? 243  ASP A C   1 ? 
ATOM   1875 O O   . ASP A 1 243 ? 3.169   -21.059 -10.376 1.00 12.58 ? 243  ASP A O   1 ? 
ATOM   1876 C CB  . ASP A 1 243 ? 3.144   -19.741 -13.370 1.00 13.39 ? 243  ASP A CB  1 ? 
ATOM   1877 C CG  . ASP A 1 243 ? 3.921   -20.026 -14.643 1.00 14.60 ? 243  ASP A CG  1 ? 
ATOM   1878 O OD1 . ASP A 1 243 ? 3.443   -20.833 -15.472 1.00 16.35 ? 243  ASP A OD1 1 ? 
ATOM   1879 O OD2 . ASP A 1 243 ? 5.024   -19.447 -14.795 1.00 13.85 ? 243  ASP A OD2 1 ? 
ATOM   1880 N N   . SER A 1 244 ? 1.199   -20.093 -10.947 1.00 12.04 ? 244  SER A N   1 ? 
ATOM   1881 C CA  . SER A 1 244 ? 0.806   -19.748 -9.559  1.00 11.67 ? 244  SER A CA  1 ? 
ATOM   1882 C C   . SER A 1 244 ? 0.528   -21.042 -8.777  1.00 12.66 ? 244  SER A C   1 ? 
ATOM   1883 O O   . SER A 1 244 ? 0.931   -21.133 -7.598  1.00 12.47 ? 244  SER A O   1 ? 
ATOM   1884 C CB  . SER A 1 244 ? -0.361  -18.818 -9.542  1.00 12.22 ? 244  SER A CB  1 ? 
ATOM   1885 O OG  . SER A 1 244 ? 0.049   -17.509 -9.888  1.00 12.13 ? 244  SER A OG  1 ? 
ATOM   1886 N N   . VAL A 1 245 ? -0.198  -21.977 -9.377  1.00 12.38 ? 245  VAL A N   1 ? 
ATOM   1887 C CA  . VAL A 1 245 ? -0.578  -23.231 -8.672  1.00 13.08 ? 245  VAL A CA  1 ? 
ATOM   1888 C C   . VAL A 1 245 ? 0.704   -23.985 -8.311  1.00 12.97 ? 245  VAL A C   1 ? 
ATOM   1889 O O   . VAL A 1 245 ? 0.840   -24.463 -7.161  1.00 12.86 ? 245  VAL A O   1 ? 
ATOM   1890 C CB  . VAL A 1 245 ? -1.533  -24.078 -9.533  1.00 14.98 ? 245  VAL A CB  1 ? 
ATOM   1891 C CG1 . VAL A 1 245 ? -1.794  -25.422 -8.888  1.00 17.45 ? 245  VAL A CG1 1 ? 
ATOM   1892 C CG2 . VAL A 1 245 ? -2.847  -23.369 -9.802  1.00 15.07 ? 245  VAL A CG2 1 ? 
ATOM   1893 N N   . ARG A 1 246 ? 1.619   -24.133 -9.255  1.00 12.53 ? 246  ARG A N   1 ? 
ATOM   1894 C CA  . ARG A 1 246 ? 2.886   -24.865 -9.012  1.00 12.72 ? 246  ARG A CA  1 ? 
ATOM   1895 C C   . ARG A 1 246 ? 3.755   -24.101 -8.013  1.00 12.46 ? 246  ARG A C   1 ? 
ATOM   1896 O O   . ARG A 1 246 ? 4.427   -24.759 -7.184  1.00 12.25 ? 246  ARG A O   1 ? 
ATOM   1897 C CB  . ARG A 1 246 ? 3.624   -25.128 -10.326 1.00 13.10 ? 246  ARG A CB  1 ? 
ATOM   1898 C CG  . ARG A 1 246 ? 2.979   -26.201 -11.179 1.00 14.66 ? 246  ARG A CG  1 ? 
ATOM   1899 C CD  . ARG A 1 246 ? 3.724   -26.334 -12.486 1.00 14.39 ? 246  ARG A CD  1 ? 
ATOM   1900 N NE  . ARG A 1 246 ? 3.527   -25.151 -13.331 1.00 15.20 ? 246  ARG A NE  1 ? 
ATOM   1901 C CZ  . ARG A 1 246 ? 4.143   -24.929 -14.486 1.00 15.52 ? 246  ARG A CZ  1 ? 
ATOM   1902 N NH1 . ARG A 1 246 ? 5.009   -25.807 -14.959 1.00 16.84 ? 246  ARG A NH1 1 ? 
ATOM   1903 N NH2 . ARG A 1 246 ? 3.903   -23.808 -15.162 1.00 16.10 ? 246  ARG A NH2 1 ? 
ATOM   1904 N N   . LEU A 1 247 ? 3.781   -22.780 -8.061  1.00 11.84 ? 247  LEU A N   1 ? 
ATOM   1905 C CA  . LEU A 1 247 ? 4.567   -22.007 -7.075  1.00 11.59 ? 247  LEU A CA  1 ? 
ATOM   1906 C C   . LEU A 1 247 ? 4.000   -22.267 -5.669  1.00 12.48 ? 247  LEU A C   1 ? 
ATOM   1907 O O   . LEU A 1 247 ? 4.794   -22.436 -4.719  1.00 12.08 ? 247  LEU A O   1 ? 
ATOM   1908 C CB  . LEU A 1 247 ? 4.526   -20.521 -7.443  1.00 12.55 ? 247  LEU A CB  1 ? 
ATOM   1909 C CG  . LEU A 1 247 ? 5.177   -19.584 -6.447  1.00 13.32 ? 247  LEU A CG  1 ? 
ATOM   1910 C CD1 . LEU A 1 247 ? 6.667   -19.866 -6.312  1.00 13.91 ? 247  LEU A CD1 1 ? 
ATOM   1911 C CD2 . LEU A 1 247 ? 4.927   -18.133 -6.838  1.00 12.75 ? 247  LEU A CD2 1 ? 
ATOM   1912 N N   . ALA A 1 248 ? 2.684   -22.204 -5.498  1.00 12.02 ? 248  ALA A N   1 ? 
ATOM   1913 C CA  . ALA A 1 248 ? 2.030   -22.440 -4.195  1.00 12.07 ? 248  ALA A CA  1 ? 
ATOM   1914 C C   . ALA A 1 248 ? 2.423   -23.840 -3.706  1.00 11.40 ? 248  ALA A C   1 ? 
ATOM   1915 O O   . ALA A 1 248 ? 2.800   -23.973 -2.535  1.00 11.88 ? 248  ALA A O   1 ? 
ATOM   1916 C CB  . ALA A 1 248 ? 0.528   -22.289 -4.320  1.00 12.54 ? 248  ALA A CB  1 ? 
ATOM   1917 N N   . GLU A 1 249 ? 2.341   -24.833 -4.578  1.00 12.08 ? 249  GLU A N   1 ? 
ATOM   1918 C CA  . GLU A 1 249 ? 2.694   -26.228 -4.195  1.00 12.78 ? 249  GLU A CA  1 ? 
ATOM   1919 C C   . GLU A 1 249 ? 4.143   -26.280 -3.701  1.00 12.98 ? 249  GLU A C   1 ? 
ATOM   1920 O O   . GLU A 1 249 ? 4.402   -26.822 -2.602  1.00 13.11 ? 249  GLU A O   1 ? 
ATOM   1921 C CB  . GLU A 1 249 ? 2.512   -27.164 -5.373  1.00 16.48 ? 249  GLU A CB  1 ? 
ATOM   1922 C CG  . GLU A 1 249 ? 2.946   -28.578 -5.106  1.00 20.14 ? 249  GLU A CG  1 ? 
ATOM   1923 C CD  . GLU A 1 249 ? 2.792   -29.457 -6.334  1.00 26.94 ? 249  GLU A CD  1 ? 
ATOM   1924 O OE1 . GLU A 1 249 ? 3.074   -28.985 -7.462  1.00 31.45 ? 249  GLU A OE1 1 ? 
ATOM   1925 O OE2 . GLU A 1 249 ? 2.351   -30.611 -6.163  1.00 34.85 ? 249  GLU A OE2 1 ? 
ATOM   1926 N N   . ARG A 1 250 ? 5.069   -25.694 -4.459  1.00 12.60 ? 250  ARG A N   1 ? 
ATOM   1927 C CA  . ARG A 1 250 ? 6.503   -25.739 -4.087  1.00 13.79 ? 250  ARG A CA  1 ? 
ATOM   1928 C C   . ARG A 1 250 ? 6.749   -24.984 -2.781  1.00 13.52 ? 250  ARG A C   1 ? 
ATOM   1929 O O   . ARG A 1 250 ? 7.473   -25.510 -1.883  1.00 13.47 ? 250  ARG A O   1 ? 
ATOM   1930 C CB  . ARG A 1 250 ? 7.335   -25.152 -5.222  1.00 15.23 ? 250  ARG A CB  1 ? 
ATOM   1931 C CG  . ARG A 1 250 ? 8.820   -25.305 -4.964  1.00 18.71 ? 250  ARG A CG  1 ? 
ATOM   1932 C CD  . ARG A 1 250 ? 9.628   -25.065 -6.194  1.00 21.01 ? 250  ARG A CD  1 ? 
ATOM   1933 N NE  . ARG A 1 250 ? 11.019  -25.449 -5.966  1.00 21.25 ? 250  ARG A NE  1 ? 
ATOM   1934 C CZ  . ARG A 1 250 ? 11.532  -26.668 -6.133  1.00 23.37 ? 250  ARG A CZ  1 ? 
ATOM   1935 N NH1 . ARG A 1 250 ? 10.780  -27.683 -6.524  1.00 25.79 ? 250  ARG A NH1 1 ? 
ATOM   1936 N NH2 . ARG A 1 250 ? 12.827  -26.856 -5.933  1.00 23.34 ? 250  ARG A NH2 1 ? 
ATOM   1937 N N   . ALA A 1 251 ? 6.151   -23.807 -2.629  1.00 12.29 ? 251  ALA A N   1 ? 
ATOM   1938 C CA  . ALA A 1 251 ? 6.364   -22.966 -1.437  1.00 12.05 ? 251  ALA A CA  1 ? 
ATOM   1939 C C   . ALA A 1 251 ? 5.797   -23.709 -0.215  1.00 12.33 ? 251  ALA A C   1 ? 
ATOM   1940 O O   . ALA A 1 251 ? 6.465   -23.753 0.806   1.00 12.82 ? 251  ALA A O   1 ? 
ATOM   1941 C CB  . ALA A 1 251 ? 5.769   -21.599 -1.638  1.00 12.64 ? 251  ALA A CB  1 ? 
ATOM   1942 N N   . ARG A 1 252 ? 4.585   -24.245 -0.308  1.00 12.86 ? 252  ARG A N   1 ? 
ATOM   1943 C CA  . ARG A 1 252 ? 3.973   -24.938 0.859   1.00 14.74 ? 252  ARG A CA  1 ? 
ATOM   1944 C C   . ARG A 1 252 ? 4.781   -26.172 1.213   1.00 14.53 ? 252  ARG A C   1 ? 
ATOM   1945 O O   . ARG A 1 252 ? 4.935   -26.406 2.434   1.00 15.03 ? 252  ARG A O   1 ? 
ATOM   1946 C CB  . ARG A 1 252 ? 2.527   -25.318 0.557   1.00 17.29 ? 252  ARG A CB  1 ? 
ATOM   1947 C CG  . ARG A 1 252 ? 1.573   -24.170 0.781   1.00 20.96 ? 252  ARG A CG  1 ? 
ATOM   1948 C CD  . ARG A 1 252 ? 1.462   -23.696 2.212   1.00 23.00 ? 252  ARG A CD  1 ? 
ATOM   1949 N NE  . ARG A 1 252 ? 1.237   -24.724 3.213   1.00 26.03 ? 252  ARG A NE  1 ? 
ATOM   1950 C CZ  . ARG A 1 252 ? 1.972   -24.952 4.315   1.00 29.35 ? 252  ARG A CZ  1 ? 
ATOM   1951 N NH1 . ARG A 1 252 ? 1.604   -25.934 5.127   1.00 30.72 ? 252  ARG A NH1 1 ? 
ATOM   1952 N NH2 . ARG A 1 252 ? 3.059   -24.238 4.614   1.00 26.78 ? 252  ARG A NH2 1 ? 
ATOM   1953 N N   . ALA A 1 253 ? 5.292   -26.897 0.217   1.00 14.09 ? 253  ALA A N   1 ? 
ATOM   1954 C CA  . ALA A 1 253 ? 6.141   -28.090 0.446   1.00 15.45 ? 253  ALA A CA  1 ? 
ATOM   1955 C C   . ALA A 1 253 ? 7.418   -27.691 1.194   1.00 15.95 ? 253  ALA A C   1 ? 
ATOM   1956 O O   . ALA A 1 253 ? 7.987   -28.570 1.902   1.00 17.74 ? 253  ALA A O   1 ? 
ATOM   1957 C CB  . ALA A 1 253 ? 6.470   -28.773 -0.846  1.00 16.54 ? 253  ALA A CB  1 ? 
ATOM   1958 N N   . ALA A 1 254 ? 7.879   -26.450 1.037   1.00 14.15 ? 254  ALA A N   1 ? 
ATOM   1959 C CA  . ALA A 1 254 ? 9.075   -25.890 1.703   1.00 14.17 ? 254  ALA A CA  1 ? 
ATOM   1960 C C   . ALA A 1 254 ? 8.723   -25.189 3.023   1.00 13.20 ? 254  ALA A C   1 ? 
ATOM   1961 O O   . ALA A 1 254 ? 9.591   -24.525 3.579   1.00 15.05 ? 254  ALA A O   1 ? 
ATOM   1962 C CB  . ALA A 1 254 ? 9.763   -24.917 0.773   1.00 14.75 ? 254  ALA A CB  1 ? 
ATOM   1963 N N   . GLY A 1 255 ? 7.484   -25.280 3.502   1.00 13.20 ? 255  GLY A N   1 ? 
ATOM   1964 C CA  . GLY A 1 255 ? 7.078   -24.763 4.810   1.00 14.20 ? 255  GLY A CA  1 ? 
ATOM   1965 C C   . GLY A 1 255 ? 6.696   -23.303 4.806   1.00 13.67 ? 255  GLY A C   1 ? 
ATOM   1966 O O   . GLY A 1 255 ? 6.536   -22.733 5.918   1.00 15.75 ? 255  GLY A O   1 ? 
ATOM   1967 N N   . VAL A 1 256 ? 6.527   -22.701 3.619   1.00 13.45 ? 256  VAL A N   1 ? 
ATOM   1968 C CA  . VAL A 1 256 ? 6.201   -21.254 3.541   1.00 13.33 ? 256  VAL A CA  1 ? 
ATOM   1969 C C   . VAL A 1 256 ? 4.707   -21.074 3.758   1.00 13.59 ? 256  VAL A C   1 ? 
ATOM   1970 O O   . VAL A 1 256 ? 3.925   -21.919 3.275   1.00 14.25 ? 256  VAL A O   1 ? 
ATOM   1971 C CB  . VAL A 1 256 ? 6.645   -20.696 2.180   1.00 13.65 ? 256  VAL A CB  1 ? 
ATOM   1972 C CG1 . VAL A 1 256 ? 6.249   -19.235 1.988   1.00 14.41 ? 256  VAL A CG1 1 ? 
ATOM   1973 C CG2 . VAL A 1 256 ? 8.140   -20.917 1.990   1.00 14.76 ? 256  VAL A CG2 1 ? 
ATOM   1974 N N   A GLN A 1 257 ? 4.331   -20.044 4.513   0.50 13.86 ? 257  GLN A N   1 ? 
ATOM   1975 N N   B GLN A 1 257 ? 4.312   -19.991 4.424   0.50 14.07 ? 257  GLN A N   1 ? 
ATOM   1976 C CA  A GLN A 1 257 ? 2.912   -19.632 4.609   0.50 14.07 ? 257  GLN A CA  1 ? 
ATOM   1977 C CA  B GLN A 1 257 ? 2.881   -19.648 4.656   0.50 14.47 ? 257  GLN A CA  1 ? 
ATOM   1978 C C   A GLN A 1 257 ? 2.569   -19.063 3.235   0.50 13.85 ? 257  GLN A C   1 ? 
ATOM   1979 C C   B GLN A 1 257 ? 2.285   -18.956 3.426   0.50 14.32 ? 257  GLN A C   1 ? 
ATOM   1980 O O   A GLN A 1 257 ? 3.278   -18.151 2.773   0.50 13.04 ? 257  GLN A O   1 ? 
ATOM   1981 O O   B GLN A 1 257 ? 2.232   -17.712 3.417   0.50 13.19 ? 257  GLN A O   1 ? 
ATOM   1982 C CB  A GLN A 1 257 ? 2.657   -18.677 5.769   0.50 15.14 ? 257  GLN A CB  1 ? 
ATOM   1983 C CB  B GLN A 1 257 ? 2.738   -18.767 5.891   0.50 15.81 ? 257  GLN A CB  1 ? 
ATOM   1984 C CG  A GLN A 1 257 ? 1.173   -18.526 6.076   0.50 17.19 ? 257  GLN A CG  1 ? 
ATOM   1985 C CG  B GLN A 1 257 ? 3.266   -19.423 7.159   0.50 18.01 ? 257  GLN A CG  1 ? 
ATOM   1986 C CD  A GLN A 1 257 ? 0.870   -17.439 7.077   0.50 19.36 ? 257  GLN A CD  1 ? 
ATOM   1987 C CD  B GLN A 1 257 ? 2.612   -20.758 7.402   0.50 20.67 ? 257  GLN A CD  1 ? 
ATOM   1988 O OE1 A GLN A 1 257 ? -0.088  -16.684 6.926   0.50 24.35 ? 257  GLN A OE1 1 ? 
ATOM   1989 O OE1 B GLN A 1 257 ? 1.393   -20.871 7.373   0.50 23.66 ? 257  GLN A OE1 1 ? 
ATOM   1990 N NE2 A GLN A 1 257 ? 1.689   -17.352 8.107   0.50 20.26 ? 257  GLN A NE2 1 ? 
ATOM   1991 N NE2 B GLN A 1 257 ? 3.423   -21.789 7.600   0.50 21.78 ? 257  GLN A NE2 1 ? 
ATOM   1992 N N   . VAL A 1 258 ? 1.662   -19.737 2.547   1.00 14.18 ? 258  VAL A N   1 ? 
ATOM   1993 C CA  . VAL A 1 258 ? 1.185   -19.321 1.205   1.00 14.65 ? 258  VAL A CA  1 ? 
ATOM   1994 C C   . VAL A 1 258 ? -0.314  -19.075 1.279   1.00 16.17 ? 258  VAL A C   1 ? 
ATOM   1995 O O   . VAL A 1 258 ? -1.058  -19.895 1.874   1.00 16.24 ? 258  VAL A O   1 ? 
ATOM   1996 C CB  . VAL A 1 258 ? 1.439   -20.398 0.136   1.00 19.30 ? 258  VAL A CB  1 ? 
ATOM   1997 C CG1 . VAL A 1 258 ? 0.924   -19.902 -1.222  1.00 18.14 ? 258  VAL A CG1 1 ? 
ATOM   1998 C CG2 . VAL A 1 258 ? 2.883   -20.798 0.064   1.00 20.24 ? 258  VAL A CG2 1 ? 
ATOM   1999 N N   . THR A 1 259 ? -0.757  -17.975 0.703   1.00 13.54 ? 259  THR A N   1 ? 
ATOM   2000 C CA  . THR A 1 259 ? -2.185  -17.767 0.390   1.00 13.75 ? 259  THR A CA  1 ? 
ATOM   2001 C C   . THR A 1 259 ? -2.271  -17.721 -1.134  1.00 14.84 ? 259  THR A C   1 ? 
ATOM   2002 O O   . THR A 1 259 ? -1.745  -16.747 -1.729  1.00 14.91 ? 259  THR A O   1 ? 
ATOM   2003 C CB  . THR A 1 259 ? -2.773  -16.538 1.063   1.00 15.28 ? 259  THR A CB  1 ? 
ATOM   2004 O OG1 . THR A 1 259 ? -2.677  -16.727 2.478   1.00 17.34 ? 259  THR A OG1 1 ? 
ATOM   2005 C CG2 . THR A 1 259 ? -4.219  -16.318 0.660   1.00 15.99 ? 259  THR A CG2 1 ? 
ATOM   2006 N N   . LEU A 1 260 ? -2.895  -18.724 -1.732  1.00 13.00 ? 260  LEU A N   1 ? 
ATOM   2007 C CA  . LEU A 1 260 ? -3.140  -18.715 -3.196  1.00 13.26 ? 260  LEU A CA  1 ? 
ATOM   2008 C C   . LEU A 1 260 ? -4.577  -18.273 -3.453  1.00 14.20 ? 260  LEU A C   1 ? 
ATOM   2009 O O   . LEU A 1 260 ? -5.498  -18.980 -3.010  1.00 14.86 ? 260  LEU A O   1 ? 
ATOM   2010 C CB  . LEU A 1 260 ? -2.893  -20.101 -3.778  1.00 14.28 ? 260  LEU A CB  1 ? 
ATOM   2011 C CG  . LEU A 1 260 ? -3.257  -20.235 -5.258  1.00 14.08 ? 260  LEU A CG  1 ? 
ATOM   2012 C CD1 . LEU A 1 260 ? -2.381  -19.335 -6.130  1.00 14.09 ? 260  LEU A CD1 1 ? 
ATOM   2013 C CD2 . LEU A 1 260 ? -3.174  -21.677 -5.701  1.00 14.99 ? 260  LEU A CD2 1 ? 
ATOM   2014 N N   . GLU A 1 261 ? -4.750  -17.145 -4.130  1.00 12.67 ? 261  GLU A N   1 ? 
ATOM   2015 C CA  . GLU A 1 261 ? -6.069  -16.552 -4.422  1.00 14.47 ? 261  GLU A CA  1 ? 
ATOM   2016 C C   . GLU A 1 261 ? -6.313  -16.605 -5.921  1.00 15.06 ? 261  GLU A C   1 ? 
ATOM   2017 O O   . GLU A 1 261 ? -5.858  -15.715 -6.643  1.00 15.65 ? 261  GLU A O   1 ? 
ATOM   2018 C CB  . GLU A 1 261 ? -6.093  -15.084 -4.046  1.00 17.52 ? 261  GLU A CB  1 ? 
ATOM   2019 C CG  . GLU A 1 261 ? -6.508  -14.780 -2.657  1.00 18.35 ? 261  GLU A CG  1 ? 
ATOM   2020 C CD  . GLU A 1 261 ? -6.725  -13.320 -2.364  1.00 17.11 ? 261  GLU A CD  1 ? 
ATOM   2021 O OE1 . GLU A 1 261 ? -6.653  -12.466 -3.286  1.00 16.25 ? 261  GLU A OE1 1 ? 
ATOM   2022 O OE2 . GLU A 1 261 ? -6.941  -13.030 -1.201  1.00 17.11 ? 261  GLU A OE2 1 ? 
ATOM   2023 N N   . PRO A 1 262 ? -7.074  -17.592 -6.422  1.00 14.57 ? 262  PRO A N   1 ? 
ATOM   2024 C CA  . PRO A 1 262 ? -7.507  -17.604 -7.822  1.00 15.27 ? 262  PRO A CA  1 ? 
ATOM   2025 C C   . PRO A 1 262 ? -8.800  -16.802 -8.018  1.00 17.06 ? 262  PRO A C   1 ? 
ATOM   2026 O O   . PRO A 1 262 ? -9.812  -17.118 -7.399  1.00 18.39 ? 262  PRO A O   1 ? 
ATOM   2027 C CB  . PRO A 1 262 ? -7.728  -19.077 -8.152  1.00 17.07 ? 262  PRO A CB  1 ? 
ATOM   2028 C CG  . PRO A 1 262 ? -7.698  -19.818 -6.798  1.00 18.80 ? 262  PRO A CG  1 ? 
ATOM   2029 C CD  . PRO A 1 262 ? -7.512  -18.797 -5.705  1.00 15.88 ? 262  PRO A CD  1 ? 
ATOM   2030 N N   . TRP A 1 263 ? -8.753  -15.766 -8.854  1.00 14.99 ? 263  TRP A N   1 ? 
ATOM   2031 C CA  . TRP A 1 263 ? -9.889  -14.854 -9.117  1.00 15.32 ? 263  TRP A CA  1 ? 
ATOM   2032 C C   . TRP A 1 263 ? -10.588 -15.306 -10.402 1.00 17.03 ? 263  TRP A C   1 ? 
ATOM   2033 O O   . TRP A 1 263 ? -10.003 -15.236 -11.483 1.00 16.11 ? 263  TRP A O   1 ? 
ATOM   2034 C CB  . TRP A 1 263 ? -9.407  -13.402 -9.178  1.00 15.02 ? 263  TRP A CB  1 ? 
ATOM   2035 C CG  . TRP A 1 263 ? -9.041  -12.819 -7.853  1.00 14.95 ? 263  TRP A CG  1 ? 
ATOM   2036 C CD1 . TRP A 1 263 ? -8.018  -13.174 -7.017  1.00 14.17 ? 263  TRP A CD1 1 ? 
ATOM   2037 C CD2 . TRP A 1 263 ? -9.740  -11.763 -7.191  1.00 14.37 ? 263  TRP A CD2 1 ? 
ATOM   2038 N NE1 . TRP A 1 263 ? -8.009  -12.359 -5.916  1.00 14.37 ? 263  TRP A NE1 1 ? 
ATOM   2039 C CE2 . TRP A 1 263 ? -9.054  -11.489 -5.990  1.00 14.50 ? 263  TRP A CE2 1 ? 
ATOM   2040 C CE3 . TRP A 1 263 ? -10.839 -10.971 -7.532  1.00 14.68 ? 263  TRP A CE3 1 ? 
ATOM   2041 C CZ2 . TRP A 1 263 ? -9.460  -10.498 -5.110  1.00 15.14 ? 263  TRP A CZ2 1 ? 
ATOM   2042 C CZ3 . TRP A 1 263 ? -11.239 -9.995  -6.659  1.00 15.35 ? 263  TRP A CZ3 1 ? 
ATOM   2043 C CH2 . TRP A 1 263 ? -10.533 -9.725  -5.482  1.00 14.98 ? 263  TRP A CH2 1 ? 
ATOM   2044 N N   . GLU A 1 264 ? -11.821 -15.784 -10.267 1.00 17.84 ? 264  GLU A N   1 ? 
ATOM   2045 C CA  . GLU A 1 264 ? -12.593 -16.363 -11.389 1.00 20.36 ? 264  GLU A CA  1 ? 
ATOM   2046 C C   . GLU A 1 264 ? -12.705 -15.359 -12.541 1.00 17.90 ? 264  GLU A C   1 ? 
ATOM   2047 O O   . GLU A 1 264 ? -13.077 -14.199 -12.326 1.00 18.52 ? 264  GLU A O   1 ? 
ATOM   2048 C CB  . GLU A 1 264 ? -13.978 -16.817 -10.920 1.00 24.33 ? 264  GLU A CB  1 ? 
ATOM   2049 C CG  . GLU A 1 264 ? -14.701 -17.634 -11.971 1.00 31.81 ? 264  GLU A CG  1 ? 
ATOM   2050 C CD  . GLU A 1 264 ? -15.483 -18.843 -11.479 1.00 40.19 ? 264  GLU A CD  1 ? 
ATOM   2051 O OE1 . GLU A 1 264 ? -16.334 -19.339 -12.255 1.00 47.46 ? 264  GLU A OE1 1 ? 
ATOM   2052 O OE2 . GLU A 1 264 ? -15.225 -19.300 -10.337 1.00 48.55 ? 264  GLU A OE2 1 ? 
ATOM   2053 N N   . ASP A 1 265 ? -12.283 -15.818 -13.708 1.00 18.40 ? 265  ASP A N   1 ? 
ATOM   2054 C CA  . ASP A 1 265 ? -12.427 -15.161 -15.034 1.00 19.23 ? 265  ASP A CA  1 ? 
ATOM   2055 C C   . ASP A 1 265 ? -11.460 -13.991 -15.182 1.00 17.89 ? 265  ASP A C   1 ? 
ATOM   2056 O O   . ASP A 1 265 ? -11.479 -13.382 -16.257 1.00 18.28 ? 265  ASP A O   1 ? 
ATOM   2057 C CB  . ASP A 1 265 ? -13.848 -14.645 -15.270 1.00 22.23 ? 265  ASP A CB  1 ? 
ATOM   2058 C CG  . ASP A 1 265 ? -14.889 -15.746 -15.321 1.00 26.51 ? 265  ASP A CG  1 ? 
ATOM   2059 O OD1 . ASP A 1 265 ? -14.609 -16.790 -15.938 1.00 28.93 ? 265  ASP A OD1 1 ? 
ATOM   2060 O OD2 . ASP A 1 265 ? -15.960 -15.542 -14.705 1.00 31.18 ? 265  ASP A OD2 1 ? 
ATOM   2061 N N   . MET A 1 266 ? -10.631 -13.675 -14.182 1.00 16.87 ? 266  MET A N   1 ? 
ATOM   2062 C CA  . MET A 1 266 ? -9.711  -12.522 -14.316 1.00 16.23 ? 266  MET A CA  1 ? 
ATOM   2063 C C   . MET A 1 266 ? -8.567  -12.859 -15.277 1.00 15.87 ? 266  MET A C   1 ? 
ATOM   2064 O O   . MET A 1 266 ? -8.172  -14.031 -15.424 1.00 15.57 ? 266  MET A O   1 ? 
ATOM   2065 C CB  . MET A 1 266 ? -9.157  -12.058 -12.964 1.00 16.24 ? 266  MET A CB  1 ? 
ATOM   2066 C CG  . MET A 1 266 ? -10.186 -11.370 -12.113 1.00 16.31 ? 266  MET A CG  1 ? 
ATOM   2067 S SD  . MET A 1 266 ? -10.943 -9.941  -12.954 1.00 18.70 ? 266  MET A SD  1 ? 
ATOM   2068 C CE  . MET A 1 266 ? -12.497 -10.646 -13.506 1.00 19.03 ? 266  MET A CE  1 ? 
ATOM   2069 N N   . ILE A 1 267 ? -8.067  -11.800 -15.922 1.00 15.99 ? 267  ILE A N   1 ? 
ATOM   2070 C CA  . ILE A 1 267 ? -6.974  -11.895 -16.914 1.00 15.25 ? 267  ILE A CA  1 ? 
ATOM   2071 C C   . ILE A 1 267 ? -5.666  -11.410 -16.273 1.00 14.07 ? 267  ILE A C   1 ? 
ATOM   2072 O O   . ILE A 1 267 ? -5.653  -10.886 -15.142 1.00 14.57 ? 267  ILE A O   1 ? 
ATOM   2073 C CB  . ILE A 1 267 ? -7.352  -11.123 -18.196 1.00 16.81 ? 267  ILE A CB  1 ? 
ATOM   2074 C CG1 . ILE A 1 267 ? -7.748  -9.657  -17.971 1.00 18.32 ? 267  ILE A CG1 1 ? 
ATOM   2075 C CG2 . ILE A 1 267 ? -8.463  -11.891 -18.883 1.00 17.11 ? 267  ILE A CG2 1 ? 
ATOM   2076 C CD1 . ILE A 1 267 ? -6.615  -8.711  -17.657 1.00 20.17 ? 267  ILE A CD1 1 ? 
ATOM   2077 N N   . HIS A 1 268 ? -4.592  -11.592 -17.006 1.00 14.73 ? 268  HIS A N   1 ? 
ATOM   2078 C CA  . HIS A 1 268 ? -3.216  -11.337 -16.521 1.00 14.07 ? 268  HIS A CA  1 ? 
ATOM   2079 C C   . HIS A 1 268 ? -3.076  -9.924  -15.961 1.00 14.42 ? 268  HIS A C   1 ? 
ATOM   2080 O O   . HIS A 1 268 ? -3.330  -8.930  -16.703 1.00 14.91 ? 268  HIS A O   1 ? 
ATOM   2081 C CB  . HIS A 1 268 ? -2.289  -11.564 -17.697 1.00 14.49 ? 268  HIS A CB  1 ? 
ATOM   2082 C CG  . HIS A 1 268 ? -0.858  -11.576 -17.341 1.00 15.86 ? 268  HIS A CG  1 ? 
ATOM   2083 N ND1 . HIS A 1 268 ? -0.352  -12.434 -16.405 1.00 17.28 ? 268  HIS A ND1 1 ? 
ATOM   2084 C CD2 . HIS A 1 268 ? 0.168   -10.830 -17.802 1.00 18.37 ? 268  HIS A CD2 1 ? 
ATOM   2085 C CE1 . HIS A 1 268 ? 0.966   -12.255 -16.338 1.00 18.64 ? 268  HIS A CE1 1 ? 
ATOM   2086 N NE2 . HIS A 1 268 ? 1.293   -11.313 -17.210 1.00 18.07 ? 268  HIS A NE2 1 ? 
ATOM   2087 N N   . VAL A 1 269 ? -2.632  -9.821  -14.709 1.00 13.38 ? 269  VAL A N   1 ? 
ATOM   2088 C CA  . VAL A 1 269 ? -2.393  -8.514  -14.036 1.00 13.93 ? 269  VAL A CA  1 ? 
ATOM   2089 C C   . VAL A 1 269 ? -3.624  -7.607  -14.229 1.00 13.30 ? 269  VAL A C   1 ? 
ATOM   2090 O O   . VAL A 1 269 ? -3.498  -6.397  -14.447 1.00 12.99 ? 269  VAL A O   1 ? 
ATOM   2091 C CB  . VAL A 1 269 ? -1.083  -7.852  -14.474 1.00 15.46 ? 269  VAL A CB  1 ? 
ATOM   2092 C CG1 . VAL A 1 269 ? -0.702  -6.791  -13.468 1.00 16.38 ? 269  VAL A CG1 1 ? 
ATOM   2093 C CG2 . VAL A 1 269 ? 0.041   -8.876  -14.621 1.00 16.01 ? 269  VAL A CG2 1 ? 
ATOM   2094 N N   . TRP A 1 270 ? -4.794  -8.174  -13.972 1.00 13.28 ? 270  TRP A N   1 ? 
ATOM   2095 C CA  . TRP A 1 270 ? -6.064  -7.412  -14.020 1.00 13.71 ? 270  TRP A CA  1 ? 
ATOM   2096 C C   . TRP A 1 270 ? -6.019  -6.234  -13.044 1.00 13.64 ? 270  TRP A C   1 ? 
ATOM   2097 O O   . TRP A 1 270 ? -6.723  -5.220  -13.267 1.00 13.67 ? 270  TRP A O   1 ? 
ATOM   2098 C CB  . TRP A 1 270 ? -7.231  -8.367  -13.754 1.00 13.97 ? 270  TRP A CB  1 ? 
ATOM   2099 C CG  . TRP A 1 270 ? -7.442  -8.715  -12.312 1.00 14.16 ? 270  TRP A CG  1 ? 
ATOM   2100 C CD1 . TRP A 1 270 ? -8.327  -8.114  -11.463 1.00 14.65 ? 270  TRP A CD1 1 ? 
ATOM   2101 C CD2 . TRP A 1 270 ? -6.835  -9.793  -11.569 1.00 14.25 ? 270  TRP A CD2 1 ? 
ATOM   2102 N NE1 . TRP A 1 270 ? -8.279  -8.718  -10.228 1.00 14.25 ? 270  TRP A NE1 1 ? 
ATOM   2103 C CE2 . TRP A 1 270 ? -7.387  -9.753  -10.273 1.00 13.77 ? 270  TRP A CE2 1 ? 
ATOM   2104 C CE3 . TRP A 1 270 ? -5.874  -10.772 -11.857 1.00 13.89 ? 270  TRP A CE3 1 ? 
ATOM   2105 C CZ2 . TRP A 1 270 ? -7.010  -10.651 -9.274  1.00 13.58 ? 270  TRP A CZ2 1 ? 
ATOM   2106 C CZ3 . TRP A 1 270 ? -5.511  -11.669 -10.868 1.00 13.80 ? 270  TRP A CZ3 1 ? 
ATOM   2107 C CH2 . TRP A 1 270 ? -6.095  -11.619 -9.606  1.00 13.72 ? 270  TRP A CH2 1 ? 
ATOM   2108 N N   . GLN A 1 271 ? -5.228  -6.319  -11.972 1.00 12.29 ? 271  GLN A N   1 ? 
ATOM   2109 C CA  . GLN A 1 271 ? -5.064  -5.221  -10.995 1.00 12.98 ? 271  GLN A CA  1 ? 
ATOM   2110 C C   . GLN A 1 271 ? -4.640  -3.918  -11.686 1.00 12.76 ? 271  GLN A C   1 ? 
ATOM   2111 O O   . GLN A 1 271 ? -5.002  -2.844  -11.195 1.00 13.76 ? 271  GLN A O   1 ? 
ATOM   2112 C CB  . GLN A 1 271 ? -4.049  -5.588  -9.910  1.00 13.18 ? 271  GLN A CB  1 ? 
ATOM   2113 C CG  . GLN A 1 271 ? -4.436  -6.856  -9.135  1.00 13.40 ? 271  GLN A CG  1 ? 
ATOM   2114 C CD  . GLN A 1 271 ? -3.867  -8.126  -9.713  1.00 13.56 ? 271  GLN A CD  1 ? 
ATOM   2115 O OE1 . GLN A 1 271 ? -3.530  -8.210  -10.895 1.00 13.89 ? 271  GLN A OE1 1 ? 
ATOM   2116 N NE2 . GLN A 1 271 ? -3.769  -9.171  -8.884  1.00 13.36 ? 271  GLN A NE2 1 ? 
ATOM   2117 N N   . ALA A 1 272 ? -3.874  -3.992  -12.774 1.00 12.91 ? 272  ALA A N   1 ? 
ATOM   2118 C CA  . ALA A 1 272 ? -3.366  -2.792  -13.475 1.00 14.42 ? 272  ALA A CA  1 ? 
ATOM   2119 C C   . ALA A 1 272 ? -4.525  -2.003  -14.092 1.00 14.73 ? 272  ALA A C   1 ? 
ATOM   2120 O O   . ALA A 1 272 ? -4.308  -0.832  -14.409 1.00 15.39 ? 272  ALA A O   1 ? 
ATOM   2121 C CB  . ALA A 1 272 ? -2.357  -3.186  -14.511 1.00 15.36 ? 272  ALA A CB  1 ? 
ATOM   2122 N N   . PHE A 1 273 ? -5.692  -2.626  -14.246 1.00 14.55 ? 273  PHE A N   1 ? 
ATOM   2123 C CA  . PHE A 1 273 ? -6.887  -2.003  -14.885 1.00 15.67 ? 273  PHE A CA  1 ? 
ATOM   2124 C C   . PHE A 1 273 ? -7.878  -1.502  -13.824 1.00 16.53 ? 273  PHE A C   1 ? 
ATOM   2125 O O   . PHE A 1 273 ? -9.039  -1.244  -14.194 1.00 16.99 ? 273  PHE A O   1 ? 
ATOM   2126 C CB  . PHE A 1 273 ? -7.509  -2.986  -15.877 1.00 16.71 ? 273  PHE A CB  1 ? 
ATOM   2127 C CG  . PHE A 1 273 ? -6.545  -3.421  -16.945 1.00 17.22 ? 273  PHE A CG  1 ? 
ATOM   2128 C CD1 . PHE A 1 273 ? -6.402  -2.680  -18.110 1.00 19.54 ? 273  PHE A CD1 1 ? 
ATOM   2129 C CD2 . PHE A 1 273 ? -5.762  -4.548  -16.784 1.00 18.63 ? 273  PHE A CD2 1 ? 
ATOM   2130 C CE1 . PHE A 1 273 ? -5.506  -3.073  -19.088 1.00 19.29 ? 273  PHE A CE1 1 ? 
ATOM   2131 C CE2 . PHE A 1 273 ? -4.870  -4.943  -17.769 1.00 20.60 ? 273  PHE A CE2 1 ? 
ATOM   2132 C CZ  . PHE A 1 273 ? -4.738  -4.196  -18.909 1.00 19.99 ? 273  PHE A CZ  1 ? 
ATOM   2133 N N   . ALA A 1 274 ? -7.454  -1.367  -12.563 1.00 16.27 ? 274  ALA A N   1 ? 
ATOM   2134 C CA  . ALA A 1 274 ? -8.320  -1.048  -11.406 1.00 17.31 ? 274  ALA A CA  1 ? 
ATOM   2135 C C   . ALA A 1 274 ? -9.081  0.265   -11.613 1.00 18.51 ? 274  ALA A C   1 ? 
ATOM   2136 O O   . ALA A 1 274 ? -10.143 0.387   -10.992 1.00 22.56 ? 274  ALA A O   1 ? 
ATOM   2137 C CB  . ALA A 1 274 ? -7.497  -0.967  -10.152 1.00 16.60 ? 274  ALA A CB  1 ? 
ATOM   2138 N N   . ALA A 1 275 ? -8.570  1.207   -12.409 1.00 20.62 ? 275  ALA A N   1 ? 
ATOM   2139 C CA  . ALA A 1 275 ? -9.274  2.480   -12.693 1.00 22.12 ? 275  ALA A CA  1 ? 
ATOM   2140 C C   . ALA A 1 275 ? -10.653 2.183   -13.286 1.00 23.98 ? 275  ALA A C   1 ? 
ATOM   2141 O O   . ALA A 1 275 ? -11.604 2.942   -12.954 1.00 27.52 ? 275  ALA A O   1 ? 
ATOM   2142 C CB  . ALA A 1 275 ? -8.454  3.342   -13.623 1.00 22.56 ? 275  ALA A CB  1 ? 
ATOM   2143 N N   . MET A 1 276 ? -10.772 1.152   -14.124 1.00 23.05 ? 276  MET A N   1 ? 
ATOM   2144 C CA  . MET A 1 276 ? -12.039 0.775   -14.798 1.00 26.91 ? 276  MET A CA  1 ? 
ATOM   2145 C C   . MET A 1 276 ? -12.609 -0.542  -14.280 1.00 27.27 ? 276  MET A C   1 ? 
ATOM   2146 O O   . MET A 1 276 ? -13.815 -0.740  -14.449 1.00 25.17 ? 276  MET A O   1 ? 
ATOM   2147 C CB  . MET A 1 276 ? -11.824 0.588   -16.298 1.00 32.18 ? 276  MET A CB  1 ? 
ATOM   2148 C CG  . MET A 1 276 ? -11.351 1.808   -17.019 1.00 38.57 ? 276  MET A CG  1 ? 
ATOM   2149 S SD  . MET A 1 276 ? -10.862 1.362   -18.710 1.00 48.00 ? 276  MET A SD  1 ? 
ATOM   2150 C CE  . MET A 1 276 ? -9.131  0.971   -18.455 1.00 47.05 ? 276  MET A CE  1 ? 
ATOM   2151 N N   . LEU A 1 277 ? -11.796 -1.447  -13.719 1.00 21.93 ? 277  LEU A N   1 ? 
ATOM   2152 C CA  . LEU A 1 277 ? -12.226 -2.842  -13.452 1.00 21.29 ? 277  LEU A CA  1 ? 
ATOM   2153 C C   . LEU A 1 277 ? -12.440 -3.048  -11.960 1.00 21.25 ? 277  LEU A C   1 ? 
ATOM   2154 O O   . LEU A 1 277 ? -11.486 -2.992  -11.187 1.00 19.75 ? 277  LEU A O   1 ? 
ATOM   2155 C CB  . LEU A 1 277 ? -11.143 -3.780  -13.979 1.00 20.12 ? 277  LEU A CB  1 ? 
ATOM   2156 C CG  . LEU A 1 277 ? -11.432 -5.270  -13.843 1.00 19.49 ? 277  LEU A CG  1 ? 
ATOM   2157 C CD1 . LEU A 1 277 ? -12.593 -5.713  -14.721 1.00 20.48 ? 277  LEU A CD1 1 ? 
ATOM   2158 C CD2 . LEU A 1 277 ? -10.203 -6.074  -14.197 1.00 18.48 ? 277  LEU A CD2 1 ? 
ATOM   2159 N N   . PRO A 1 278 ? -13.695 -3.203  -11.484 1.00 20.68 ? 278  PRO A N   1 ? 
ATOM   2160 C CA  . PRO A 1 278 ? -13.951 -3.321  -10.053 1.00 20.72 ? 278  PRO A CA  1 ? 
ATOM   2161 C C   . PRO A 1 278 ? -13.120 -4.415  -9.372  1.00 18.42 ? 278  PRO A C   1 ? 
ATOM   2162 O O   . PRO A 1 278 ? -12.632 -4.122  -8.283  1.00 18.50 ? 278  PRO A O   1 ? 
ATOM   2163 C CB  . PRO A 1 278 ? -15.455 -3.609  -9.995  1.00 21.63 ? 278  PRO A CB  1 ? 
ATOM   2164 C CG  . PRO A 1 278 ? -15.984 -2.857  -11.179 1.00 21.66 ? 278  PRO A CG  1 ? 
ATOM   2165 C CD  . PRO A 1 278 ? -14.945 -3.087  -12.257 1.00 22.20 ? 278  PRO A CD  1 ? 
ATOM   2166 N N   . GLU A 1 279 ? -12.971 -5.572  -10.010 1.00 18.44 ? 279  GLU A N   1 ? 
ATOM   2167 C CA  . GLU A 1 279 ? -12.185 -6.712  -9.454  1.00 17.88 ? 279  GLU A CA  1 ? 
ATOM   2168 C C   . GLU A 1 279 ? -10.725 -6.287  -9.322  1.00 17.03 ? 279  GLU A C   1 ? 
ATOM   2169 O O   . GLU A 1 279 ? -10.047 -6.859  -8.463  1.00 15.40 ? 279  GLU A O   1 ? 
ATOM   2170 C CB  . GLU A 1 279 ? -12.247 -7.960  -10.323 1.00 20.07 ? 279  GLU A CB  1 ? 
ATOM   2171 C CG  . GLU A 1 279 ? -13.609 -8.626  -10.363 1.00 21.99 ? 279  GLU A CG  1 ? 
ATOM   2172 C CD  . GLU A 1 279 ? -14.531 -8.124  -11.462 1.00 23.40 ? 279  GLU A CD  1 ? 
ATOM   2173 O OE1 . GLU A 1 279 ? -14.299 -6.987  -11.999 1.00 21.61 ? 279  GLU A OE1 1 ? 
ATOM   2174 O OE2 . GLU A 1 279 ? -15.510 -8.863  -11.738 1.00 25.28 ? 279  GLU A OE2 1 ? 
ATOM   2175 N N   . GLY A 1 280 ? -10.237 -5.365  -10.152 1.00 16.11 ? 280  GLY A N   1 ? 
ATOM   2176 C CA  . GLY A 1 280 ? -8.862  -4.857  -9.999  1.00 15.65 ? 280  GLY A CA  1 ? 
ATOM   2177 C C   . GLY A 1 280 ? -8.719  -4.089  -8.699  1.00 16.68 ? 280  GLY A C   1 ? 
ATOM   2178 O O   . GLY A 1 280 ? -7.767  -4.340  -7.949  1.00 16.58 ? 280  GLY A O   1 ? 
ATOM   2179 N N   . GLN A 1 281 ? -9.657  -3.179  -8.400  1.00 16.40 ? 281  GLN A N   1 ? 
ATOM   2180 C CA  . GLN A 1 281 ? -9.601  -2.404  -7.144  1.00 18.73 ? 281  GLN A CA  1 ? 
ATOM   2181 C C   . GLN A 1 281 ? -9.827  -3.371  -5.970  1.00 16.44 ? 281  GLN A C   1 ? 
ATOM   2182 O O   . GLN A 1 281 ? -9.145  -3.200  -4.959  1.00 17.24 ? 281  GLN A O   1 ? 
ATOM   2183 C CB  . GLN A 1 281 ? -10.563 -1.211  -7.144  1.00 22.47 ? 281  GLN A CB  1 ? 
ATOM   2184 C CG  . GLN A 1 281 ? -10.207 -0.145  -6.095  1.00 27.21 ? 281  GLN A CG  1 ? 
ATOM   2185 C CD  . GLN A 1 281 ? -8.738  0.214   -5.954  1.00 32.46 ? 281  GLN A CD  1 ? 
ATOM   2186 O OE1 . GLN A 1 281 ? -8.028  0.579   -6.909  1.00 35.19 ? 281  GLN A OE1 1 ? 
ATOM   2187 N NE2 . GLN A 1 281 ? -8.254  0.155   -4.722  1.00 33.70 ? 281  GLN A NE2 1 ? 
ATOM   2188 N N   . GLN A 1 282 ? -10.738 -4.336  -6.088  1.00 16.62 ? 282  GLN A N   1 ? 
ATOM   2189 C CA  . GLN A 1 282 ? -11.006 -5.307  -4.983  1.00 17.01 ? 282  GLN A CA  1 ? 
ATOM   2190 C C   . GLN A 1 282 ? -9.726  -6.092  -4.679  1.00 15.45 ? 282  GLN A C   1 ? 
ATOM   2191 O O   . GLN A 1 282 ? -9.410  -6.270  -3.487  1.00 15.07 ? 282  GLN A O   1 ? 
ATOM   2192 C CB  . GLN A 1 282 ? -12.131 -6.275  -5.335  1.00 18.47 ? 282  GLN A CB  1 ? 
ATOM   2193 C CG  . GLN A 1 282 ? -13.499 -5.614  -5.427  1.00 21.90 ? 282  GLN A CG  1 ? 
ATOM   2194 C CD  . GLN A 1 282 ? -14.443 -6.422  -6.286  1.00 23.70 ? 282  GLN A CD  1 ? 
ATOM   2195 O OE1 . GLN A 1 282 ? -14.359 -7.642  -6.382  1.00 26.67 ? 282  GLN A OE1 1 ? 
ATOM   2196 N NE2 . GLN A 1 282 ? -15.371 -5.744  -6.946  1.00 28.56 ? 282  GLN A NE2 1 ? 
ATOM   2197 N N   . ALA A 1 283 ? -9.010  -6.539  -5.715  1.00 14.63 ? 283  ALA A N   1 ? 
ATOM   2198 C CA  . ALA A 1 283 ? -7.767  -7.330  -5.526  1.00 13.43 ? 283  ALA A CA  1 ? 
ATOM   2199 C C   . ALA A 1 283 ? -6.708  -6.454  -4.853  1.00 13.39 ? 283  ALA A C   1 ? 
ATOM   2200 O O   . ALA A 1 283 ? -5.983  -6.933  -3.950  1.00 12.86 ? 283  ALA A O   1 ? 
ATOM   2201 C CB  . ALA A 1 283 ? -7.302  -7.917  -6.841  1.00 13.24 ? 283  ALA A CB  1 ? 
ATOM   2202 N N   . ILE A 1 284 ? -6.588  -5.183  -5.236  1.00 12.29 ? 284  ILE A N   1 ? 
ATOM   2203 C CA  . ILE A 1 284 ? -5.597  -4.267  -4.617  1.00 13.08 ? 284  ILE A CA  1 ? 
ATOM   2204 C C   . ILE A 1 284 ? -5.968  -4.031  -3.151  1.00 12.76 ? 284  ILE A C   1 ? 
ATOM   2205 O O   . ILE A 1 284 ? -5.071  -3.993  -2.314  1.00 13.54 ? 284  ILE A O   1 ? 
ATOM   2206 C CB  . ILE A 1 284 ? -5.447  -2.965  -5.421  1.00 13.60 ? 284  ILE A CB  1 ? 
ATOM   2207 C CG1 . ILE A 1 284 ? -4.865  -3.274  -6.808  1.00 14.59 ? 284  ILE A CG1 1 ? 
ATOM   2208 C CG2 . ILE A 1 284 ? -4.602  -1.978  -4.639  1.00 15.38 ? 284  ILE A CG2 1 ? 
ATOM   2209 C CD1 . ILE A 1 284 ? -4.849  -2.098  -7.759  1.00 15.28 ? 284  ILE A CD1 1 ? 
ATOM   2210 N N   . GLU A 1 285 ? -7.259  -3.882  -2.837  1.00 14.19 ? 285  GLU A N   1 ? 
ATOM   2211 C CA  . GLU A 1 285 ? -7.660  -3.724  -1.413  1.00 15.76 ? 285  GLU A CA  1 ? 
ATOM   2212 C C   . GLU A 1 285 ? -7.221  -4.965  -0.625  1.00 13.98 ? 285  GLU A C   1 ? 
ATOM   2213 O O   . GLU A 1 285 ? -6.715  -4.771  0.509   1.00 14.91 ? 285  GLU A O   1 ? 
ATOM   2214 C CB  . GLU A 1 285 ? -9.166  -3.456  -1.305  1.00 18.76 ? 285  GLU A CB  1 ? 
ATOM   2215 C CG  . GLU A 1 285 ? -9.525  -2.069  -1.812  1.00 23.31 ? 285  GLU A CG  1 ? 
ATOM   2216 C CD  . GLU A 1 285 ? -8.804  -0.886  -1.173  1.00 30.71 ? 285  GLU A CD  1 ? 
ATOM   2217 O OE1 . GLU A 1 285 ? -8.402  -0.973  0.017   1.00 37.71 ? 285  GLU A OE1 1 ? 
ATOM   2218 O OE2 . GLU A 1 285 ? -8.623  0.140   -1.876  1.00 40.55 ? 285  GLU A OE2 1 ? 
ATOM   2219 N N   . ARG A 1 286 ? -7.332  -6.148  -1.220  1.00 14.40 ? 286  ARG A N   1 ? 
ATOM   2220 C CA  . ARG A 1 286 ? -6.902  -7.423  -0.576  1.00 15.12 ? 286  ARG A CA  1 ? 
ATOM   2221 C C   . ARG A 1 286 ? -5.381  -7.393  -0.351  1.00 14.36 ? 286  ARG A C   1 ? 
ATOM   2222 O O   . ARG A 1 286 ? -4.921  -7.783  0.738   1.00 14.10 ? 286  ARG A O   1 ? 
ATOM   2223 C CB  . ARG A 1 286 ? -7.319  -8.620  -1.415  1.00 17.45 ? 286  ARG A CB  1 ? 
ATOM   2224 C CG  . ARG A 1 286 ? -6.861  -9.944  -0.848  1.00 20.40 ? 286  ARG A CG  1 ? 
ATOM   2225 C CD  . ARG A 1 286 ? -7.498  -10.291 0.504   1.00 23.35 ? 286  ARG A CD  1 ? 
ATOM   2226 N NE  . ARG A 1 286 ? -6.800  -11.471 0.959   1.00 25.09 ? 286  ARG A NE  1 ? 
ATOM   2227 C CZ  . ARG A 1 286 ? -6.096  -11.610 2.074   1.00 25.58 ? 286  ARG A CZ  1 ? 
ATOM   2228 N NH1 . ARG A 1 286 ? -6.060  -10.655 2.989   1.00 28.50 ? 286  ARG A NH1 1 ? 
ATOM   2229 N NH2 . ARG A 1 286 ? -5.491  -12.763 2.311   1.00 29.30 ? 286  ARG A NH2 1 ? 
ATOM   2230 N N   . ILE A 1 287 ? -4.610  -6.950  -1.343  1.00 13.28 ? 287  ILE A N   1 ? 
ATOM   2231 C CA  . ILE A 1 287 ? -3.140  -6.801  -1.171  1.00 12.67 ? 287  ILE A CA  1 ? 
ATOM   2232 C C   . ILE A 1 287 ? -2.856  -5.916  0.051   1.00 13.14 ? 287  ILE A C   1 ? 
ATOM   2233 O O   . ILE A 1 287 ? -1.998  -6.272  0.854   1.00 13.00 ? 287  ILE A O   1 ? 
ATOM   2234 C CB  . ILE A 1 287 ? -2.472  -6.236  -2.448  1.00 12.90 ? 287  ILE A CB  1 ? 
ATOM   2235 C CG1 . ILE A 1 287 ? -2.591  -7.205  -3.630  1.00 13.60 ? 287  ILE A CG1 1 ? 
ATOM   2236 C CG2 . ILE A 1 287 ? -1.041  -5.890  -2.154  1.00 13.31 ? 287  ILE A CG2 1 ? 
ATOM   2237 C CD1 . ILE A 1 287 ? -2.273  -6.562  -4.982  1.00 13.81 ? 287  ILE A CD1 1 ? 
ATOM   2238 N N   . GLY A 1 288 ? -3.512  -4.760  0.153   1.00 13.67 ? 288  GLY A N   1 ? 
ATOM   2239 C CA  . GLY A 1 288 ? -3.281  -3.843  1.276   1.00 13.79 ? 288  GLY A CA  1 ? 
ATOM   2240 C C   . GLY A 1 288 ? -3.635  -4.498  2.604   1.00 13.63 ? 288  GLY A C   1 ? 
ATOM   2241 O O   . GLY A 1 288 ? -2.870  -4.319  3.566   1.00 14.48 ? 288  GLY A O   1 ? 
ATOM   2242 N N   . GLU A 1 289 ? -4.744  -5.241  2.650   1.00 14.46 ? 289  GLU A N   1 ? 
ATOM   2243 C CA  . GLU A 1 289 ? -5.187  -5.922  3.895   1.00 16.20 ? 289  GLU A CA  1 ? 
ATOM   2244 C C   . GLU A 1 289 ? -4.109  -6.919  4.316   1.00 15.54 ? 289  GLU A C   1 ? 
ATOM   2245 O O   . GLU A 1 289 ? -3.748  -6.943  5.511   1.00 15.65 ? 289  GLU A O   1 ? 
ATOM   2246 C CB  . GLU A 1 289 ? -6.522  -6.620  3.666   1.00 19.68 ? 289  GLU A CB  1 ? 
ATOM   2247 C CG  . GLU A 1 289 ? -7.034  -7.396  4.869   1.00 25.29 ? 289  GLU A CG  1 ? 
ATOM   2248 C CD  . GLU A 1 289 ? -8.272  -8.260  4.659   1.00 33.20 ? 289  GLU A CD  1 ? 
ATOM   2249 O OE1 . GLU A 1 289 ? -8.613  -8.570  3.495   1.00 36.24 ? 289  GLU A OE1 1 ? 
ATOM   2250 O OE2 . GLU A 1 289 ? -8.887  -8.663  5.687   1.00 39.37 ? 289  GLU A OE2 1 ? 
ATOM   2251 N N   . PHE A 1 290 ? -3.609  -7.694  3.357   1.00 13.71 ? 290  PHE A N   1 ? 
ATOM   2252 C CA  . PHE A 1 290 ? -2.581  -8.732  3.583   1.00 13.06 ? 290  PHE A CA  1 ? 
ATOM   2253 C C   . PHE A 1 290 ? -1.324  -8.090  4.151   1.00 13.02 ? 290  PHE A C   1 ? 
ATOM   2254 O O   . PHE A 1 290 ? -0.787  -8.567  5.145   1.00 13.19 ? 290  PHE A O   1 ? 
ATOM   2255 C CB  . PHE A 1 290 ? -2.307  -9.490  2.290   1.00 13.43 ? 290  PHE A CB  1 ? 
ATOM   2256 C CG  . PHE A 1 290 ? -1.209  -10.509 2.401   1.00 12.36 ? 290  PHE A CG  1 ? 
ATOM   2257 C CD1 . PHE A 1 290 ? -1.445  -11.796 2.869   1.00 13.67 ? 290  PHE A CD1 1 ? 
ATOM   2258 C CD2 . PHE A 1 290 ? 0.062   -10.188 1.975   1.00 12.93 ? 290  PHE A CD2 1 ? 
ATOM   2259 C CE1 . PHE A 1 290 ? -0.416  -12.717 2.942   1.00 13.82 ? 290  PHE A CE1 1 ? 
ATOM   2260 C CE2 . PHE A 1 290 ? 1.095   -11.105 2.069   1.00 13.06 ? 290  PHE A CE2 1 ? 
ATOM   2261 C CZ  . PHE A 1 290 ? 0.854   -12.363 2.548   1.00 13.31 ? 290  PHE A CZ  1 ? 
ATOM   2262 N N   . LEU A 1 291 ? -0.846  -7.011  3.538   1.00 12.58 ? 291  LEU A N   1 ? 
ATOM   2263 C CA  . LEU A 1 291 ? 0.403   -6.375  3.999   1.00 12.57 ? 291  LEU A CA  1 ? 
ATOM   2264 C C   . LEU A 1 291 ? 0.199   -5.774  5.384   1.00 13.50 ? 291  LEU A C   1 ? 
ATOM   2265 O O   . LEU A 1 291 ? 1.063   -5.995  6.230   1.00 14.61 ? 291  LEU A O   1 ? 
ATOM   2266 C CB  . LEU A 1 291 ? 0.843   -5.313  2.999   1.00 13.52 ? 291  LEU A CB  1 ? 
ATOM   2267 C CG  . LEU A 1 291 ? 1.320   -5.892  1.672   1.00 13.57 ? 291  LEU A CG  1 ? 
ATOM   2268 C CD1 . LEU A 1 291 ? 1.603   -4.766  0.699   1.00 14.78 ? 291  LEU A CD1 1 ? 
ATOM   2269 C CD2 . LEU A 1 291 ? 2.519   -6.804  1.879   1.00 14.90 ? 291  LEU A CD2 1 ? 
ATOM   2270 N N   . ARG A 1 292 ? -0.901  -5.053  5.594   1.00 13.83 ? 292  ARG A N   1 ? 
ATOM   2271 C CA  . ARG A 1 292 ? -1.141  -4.417  6.916   1.00 15.84 ? 292  ARG A CA  1 ? 
ATOM   2272 C C   . ARG A 1 292 ? -1.246  -5.481  8.007   1.00 16.33 ? 292  ARG A C   1 ? 
ATOM   2273 O O   . ARG A 1 292 ? -0.733  -5.210  9.111   1.00 17.01 ? 292  ARG A O   1 ? 
ATOM   2274 C CB  . ARG A 1 292 ? -2.332  -3.472  6.846   1.00 16.78 ? 292  ARG A CB  1 ? 
ATOM   2275 C CG  . ARG A 1 292 ? -1.946  -2.187  6.139   1.00 18.21 ? 292  ARG A CG  1 ? 
ATOM   2276 C CD  . ARG A 1 292 ? -3.027  -1.128  6.117   1.00 21.78 ? 292  ARG A CD  1 ? 
ATOM   2277 N NE  . ARG A 1 292 ? -4.039  -1.448  5.128   1.00 22.25 ? 292  ARG A NE  1 ? 
ATOM   2278 C CZ  . ARG A 1 292 ? -5.193  -2.056  5.371   1.00 25.17 ? 292  ARG A CZ  1 ? 
ATOM   2279 N NH1 . ARG A 1 292 ? -5.513  -2.472  6.588   1.00 26.86 ? 292  ARG A NH1 1 ? 
ATOM   2280 N NH2 . ARG A 1 292 ? -6.026  -2.268  4.373   1.00 25.92 ? 292  ARG A NH2 1 ? 
ATOM   2281 N N   . GLN A 1 293 ? -1.849  -6.629  7.718   1.00 16.03 ? 293  GLN A N   1 ? 
ATOM   2282 C CA  . GLN A 1 293 ? -1.954  -7.743  8.700   1.00 18.58 ? 293  GLN A CA  1 ? 
ATOM   2283 C C   . GLN A 1 293 ? -0.553  -8.200  9.095   1.00 18.25 ? 293  GLN A C   1 ? 
ATOM   2284 O O   . GLN A 1 293 ? -0.309  -8.460  10.289  1.00 19.73 ? 293  GLN A O   1 ? 
ATOM   2285 C CB  . GLN A 1 293 ? -2.729  -8.916  8.112   1.00 22.86 ? 293  GLN A CB  1 ? 
ATOM   2286 C CG  . GLN A 1 293 ? -2.904  -10.073 9.091   1.00 30.58 ? 293  GLN A CG  1 ? 
ATOM   2287 C CD  . GLN A 1 293 ? -2.830  -11.411 8.398   1.00 36.67 ? 293  GLN A CD  1 ? 
ATOM   2288 O OE1 . GLN A 1 293 ? -3.395  -11.609 7.321   1.00 49.19 ? 293  GLN A OE1 1 ? 
ATOM   2289 N NE2 . GLN A 1 293 ? -2.121  -12.350 9.006   1.00 42.61 ? 293  GLN A NE2 1 ? 
ATOM   2290 N N   . HIS A 1 294 ? 0.362   -8.318  8.141   1.00 16.14 ? 294  HIS A N   1 ? 
ATOM   2291 C CA  . HIS A 1 294 ? 1.713   -8.862  8.416   1.00 15.38 ? 294  HIS A CA  1 ? 
ATOM   2292 C C   . HIS A 1 294 ? 2.636   -7.807  9.018   1.00 16.58 ? 294  HIS A C   1 ? 
ATOM   2293 O O   . HIS A 1 294 ? 3.678   -8.178  9.568   1.00 18.36 ? 294  HIS A O   1 ? 
ATOM   2294 C CB  . HIS A 1 294 ? 2.274   -9.536  7.166   1.00 16.07 ? 294  HIS A CB  1 ? 
ATOM   2295 C CG  . HIS A 1 294 ? 1.634   -10.850 6.909   1.00 16.50 ? 294  HIS A CG  1 ? 
ATOM   2296 N ND1 . HIS A 1 294 ? 1.880   -11.966 7.707   1.00 20.25 ? 294  HIS A ND1 1 ? 
ATOM   2297 C CD2 . HIS A 1 294 ? 0.693   -11.225 6.024   1.00 17.64 ? 294  HIS A CD2 1 ? 
ATOM   2298 C CE1 . HIS A 1 294 ? 1.152   -12.971 7.268   1.00 18.70 ? 294  HIS A CE1 1 ? 
ATOM   2299 N NE2 . HIS A 1 294 ? 0.414   -12.546 6.259   1.00 18.79 ? 294  HIS A NE2 1 ? 
ATOM   2300 N N   . TRP A 1 295 ? 2.283   -6.531  8.941   1.00 14.71 ? 295  TRP A N   1 ? 
ATOM   2301 C CA  . TRP A 1 295 ? 3.053   -5.439  9.571   1.00 15.87 ? 295  TRP A CA  1 ? 
ATOM   2302 C C   . TRP A 1 295 ? 2.571   -5.155  11.001  1.00 18.55 ? 295  TRP A C   1 ? 
ATOM   2303 O O   . TRP A 1 295 ? 3.335   -4.516  11.734  1.00 20.15 ? 295  TRP A O   1 ? 
ATOM   2304 C CB  . TRP A 1 295 ? 2.961   -4.186  8.715   1.00 15.13 ? 295  TRP A CB  1 ? 
ATOM   2305 C CG  . TRP A 1 295 ? 3.767   -4.261  7.457   1.00 14.68 ? 295  TRP A CG  1 ? 
ATOM   2306 C CD1 . TRP A 1 295 ? 4.949   -4.920  7.258   1.00 15.25 ? 295  TRP A CD1 1 ? 
ATOM   2307 C CD2 . TRP A 1 295 ? 3.506   -3.524  6.253   1.00 14.13 ? 295  TRP A CD2 1 ? 
ATOM   2308 N NE1 . TRP A 1 295 ? 5.394   -4.705  5.982   1.00 14.88 ? 295  TRP A NE1 1 ? 
ATOM   2309 C CE2 . TRP A 1 295 ? 4.535   -3.845  5.344   1.00 14.95 ? 295  TRP A CE2 1 ? 
ATOM   2310 C CE3 . TRP A 1 295 ? 2.479   -2.667  5.845   1.00 14.84 ? 295  TRP A CE3 1 ? 
ATOM   2311 C CZ2 . TRP A 1 295 ? 4.563   -3.316  4.058   1.00 15.40 ? 295  TRP A CZ2 1 ? 
ATOM   2312 C CZ3 . TRP A 1 295 ? 2.512   -2.148  4.569   1.00 15.08 ? 295  TRP A CZ3 1 ? 
ATOM   2313 C CH2 . TRP A 1 295 ? 3.549   -2.462  3.700   1.00 14.89 ? 295  TRP A CH2 1 ? 
ATOM   2314 N N   . GLN A 1 296 ? 1.350   -5.549  11.354  1.00 22.78 ? 296  GLN A N   1 ? 
ATOM   2315 C CA  . GLN A 1 296 ? 0.827   -5.421  12.752  1.00 31.75 ? 296  GLN A CA  1 ? 
ATOM   2316 C C   . GLN A 1 296 ? 1.806   -6.078  13.742  1.00 37.09 ? 296  GLN A C   1 ? 
ATOM   2317 O O   . GLN A 1 296 ? 2.208   -5.539  14.794  1.00 39.05 ? 296  GLN A O   1 ? 
ATOM   2318 C CB  . GLN A 1 296 ? -0.546  -6.079  12.887  1.00 39.46 ? 296  GLN A CB  1 ? 
ATOM   2319 C CG  . GLN A 1 296 ? -1.704  -5.177  12.495  1.00 45.97 ? 296  GLN A CG  1 ? 
ATOM   2320 C CD  . GLN A 1 296 ? -3.020  -5.831  12.842  1.00 54.95 ? 296  GLN A CD  1 ? 
ATOM   2321 O OE1 . GLN A 1 296 ? -3.365  -6.880  12.300  1.00 63.15 ? 296  GLN A OE1 1 ? 
ATOM   2322 N NE2 . GLN A 1 296 ? -3.759  -5.227  13.762  1.00 59.90 ? 296  GLN A NE2 1 ? 
ATOM   2323 O OXT . GLN A 1 296 ? 2.240   -7.209  13.520  1.00 39.39 ? 296  GLN A OXT 1 ? 
ATOM   2324 N N   . ALA B 1 2   ? 44.908  9.274   -36.172 1.00 32.42 ? 2    ALA B N   1 ? 
ATOM   2325 C CA  . ALA B 1 2   ? 44.440  9.781   -34.853 1.00 31.05 ? 2    ALA B CA  1 ? 
ATOM   2326 C C   . ALA B 1 2   ? 45.234  9.087   -33.743 1.00 30.03 ? 2    ALA B C   1 ? 
ATOM   2327 O O   . ALA B 1 2   ? 45.876  8.045   -34.027 1.00 29.29 ? 2    ALA B O   1 ? 
ATOM   2328 C CB  . ALA B 1 2   ? 42.952  9.549   -34.711 1.00 31.30 ? 2    ALA B CB  1 ? 
ATOM   2329 N N   . SER B 1 3   ? 45.231  9.660   -32.537 1.00 25.39 ? 3    SER B N   1 ? 
ATOM   2330 C CA  . SER B 1 3   ? 45.910  9.085   -31.348 1.00 26.13 ? 3    SER B CA  1 ? 
ATOM   2331 C C   . SER B 1 3   ? 45.428  7.637   -31.155 1.00 24.15 ? 3    SER B C   1 ? 
ATOM   2332 O O   . SER B 1 3   ? 44.304  7.308   -31.600 1.00 23.35 ? 3    SER B O   1 ? 
ATOM   2333 C CB  . SER B 1 3   ? 45.628  9.925   -30.130 1.00 25.46 ? 3    SER B CB  1 ? 
ATOM   2334 O OG  . SER B 1 3   ? 44.235  9.915   -29.845 1.00 26.15 ? 3    SER B OG  1 ? 
ATOM   2335 N N   . GLU B 1 4   ? 46.226  6.798   -30.494 1.00 24.93 ? 4    GLU B N   1 ? 
ATOM   2336 C CA  . GLU B 1 4   ? 45.811  5.412   -30.158 1.00 26.67 ? 4    GLU B CA  1 ? 
ATOM   2337 C C   . GLU B 1 4   ? 44.611  5.471   -29.209 1.00 22.95 ? 4    GLU B C   1 ? 
ATOM   2338 O O   . GLU B 1 4   ? 43.770  4.539   -29.253 1.00 23.51 ? 4    GLU B O   1 ? 
ATOM   2339 C CB  . GLU B 1 4   ? 46.945  4.601   -29.529 1.00 29.51 ? 4    GLU B CB  1 ? 
ATOM   2340 C CG  . GLU B 1 4   ? 46.623  3.112   -29.440 1.00 33.66 ? 4    GLU B CG  1 ? 
ATOM   2341 C CD  . GLU B 1 4   ? 46.461  2.385   -30.773 1.00 37.36 ? 4    GLU B CD  1 ? 
ATOM   2342 O OE1 . GLU B 1 4   ? 46.911  2.924   -31.805 1.00 41.04 ? 4    GLU B OE1 1 ? 
ATOM   2343 O OE2 . GLU B 1 4   ? 45.900  1.267   -30.782 1.00 40.67 ? 4    GLU B OE2 1 ? 
ATOM   2344 N N   . ALA B 1 5   ? 44.524  6.513   -28.380 1.00 21.07 ? 5    ALA B N   1 ? 
ATOM   2345 C CA  . ALA B 1 5   ? 43.408  6.729   -27.435 1.00 20.52 ? 5    ALA B CA  1 ? 
ATOM   2346 C C   . ALA B 1 5   ? 42.090  6.697   -28.210 1.00 20.20 ? 5    ALA B C   1 ? 
ATOM   2347 O O   . ALA B 1 5   ? 41.091  6.216   -27.678 1.00 18.10 ? 5    ALA B O   1 ? 
ATOM   2348 C CB  . ALA B 1 5   ? 43.566  8.043   -26.709 1.00 21.10 ? 5    ALA B CB  1 ? 
ATOM   2349 N N   . LEU B 1 6   ? 42.057  7.202   -29.446 1.00 18.89 ? 6    LEU B N   1 ? 
ATOM   2350 C CA  . LEU B 1 6   ? 40.768  7.244   -30.179 1.00 18.38 ? 6    LEU B CA  1 ? 
ATOM   2351 C C   . LEU B 1 6   ? 40.255  5.820   -30.402 1.00 18.34 ? 6    LEU B C   1 ? 
ATOM   2352 O O   . LEU B 1 6   ? 39.069  5.567   -30.160 1.00 17.54 ? 6    LEU B O   1 ? 
ATOM   2353 C CB  . LEU B 1 6   ? 40.914  7.988   -31.506 1.00 19.35 ? 6    LEU B CB  1 ? 
ATOM   2354 C CG  . LEU B 1 6   ? 39.652  7.963   -32.360 1.00 20.63 ? 6    LEU B CG  1 ? 
ATOM   2355 C CD1 . LEU B 1 6   ? 38.564  8.814   -31.730 1.00 20.36 ? 6    LEU B CD1 1 ? 
ATOM   2356 C CD2 . LEU B 1 6   ? 39.953  8.366   -33.780 1.00 23.72 ? 6    LEU B CD2 1 ? 
ATOM   2357 N N   A THR B 1 7   ? 41.097  4.896   -30.871 0.24 17.87 ? 7    THR B N   1 ? 
ATOM   2358 N N   B THR B 1 7   ? 41.114  4.932   -30.880 0.76 17.28 ? 7    THR B N   1 ? 
ATOM   2359 C CA  A THR B 1 7   ? 40.641  3.518   -31.214 0.24 18.34 ? 7    THR B CA  1 ? 
ATOM   2360 C CA  B THR B 1 7   ? 40.695  3.553   -31.230 0.76 19.08 ? 7    THR B CA  1 ? 
ATOM   2361 C C   A THR B 1 7   ? 40.112  2.857   -29.938 0.24 17.93 ? 7    THR B C   1 ? 
ATOM   2362 C C   B THR B 1 7   ? 40.158  2.868   -29.967 0.76 17.87 ? 7    THR B C   1 ? 
ATOM   2363 O O   A THR B 1 7   ? 39.071  2.143   -29.993 0.24 18.17 ? 7    THR B O   1 ? 
ATOM   2364 O O   B THR B 1 7   ? 39.143  2.162   -30.063 0.76 18.79 ? 7    THR B O   1 ? 
ATOM   2365 C CB  A THR B 1 7   ? 41.735  2.660   -31.864 0.24 19.06 ? 7    THR B CB  1 ? 
ATOM   2366 C CB  B THR B 1 7   ? 41.811  2.766   -31.919 0.76 21.70 ? 7    THR B CB  1 ? 
ATOM   2367 O OG1 A THR B 1 7   ? 42.801  2.466   -30.934 0.24 19.29 ? 7    THR B OG1 1 ? 
ATOM   2368 O OG1 B THR B 1 7   ? 42.253  3.505   -33.063 0.76 25.30 ? 7    THR B OG1 1 ? 
ATOM   2369 C CG2 A THR B 1 7   ? 42.276  3.254   -33.148 0.24 19.35 ? 7    THR B CG2 1 ? 
ATOM   2370 C CG2 B THR B 1 7   ? 41.325  1.399   -32.337 0.76 21.07 ? 7    THR B CG2 1 ? 
ATOM   2371 N N   . MET B 1 8   ? 40.801  3.084   -28.820 1.00 17.84 ? 8    MET B N   1 ? 
ATOM   2372 C CA  . MET B 1 8   ? 40.422  2.416   -27.559 1.00 17.97 ? 8    MET B CA  1 ? 
ATOM   2373 C C   . MET B 1 8   ? 39.116  3.034   -27.067 1.00 18.10 ? 8    MET B C   1 ? 
ATOM   2374 O O   . MET B 1 8   ? 38.260  2.277   -26.579 1.00 16.90 ? 8    MET B O   1 ? 
ATOM   2375 C CB  . MET B 1 8   ? 41.534  2.549   -26.529 1.00 19.69 ? 8    MET B CB  1 ? 
ATOM   2376 C CG  . MET B 1 8   ? 42.705  1.749   -26.972 1.00 20.07 ? 8    MET B CG  1 ? 
ATOM   2377 S SD  . MET B 1 8   ? 43.963  1.674   -25.699 1.00 26.39 ? 8    MET B SD  1 ? 
ATOM   2378 C CE  . MET B 1 8   ? 44.566  3.354   -25.787 1.00 26.26 ? 8    MET B CE  1 ? 
ATOM   2379 N N   . ILE B 1 9   ? 38.947  4.346   -27.200 1.00 17.16 ? 9    ILE B N   1 ? 
ATOM   2380 C CA  . ILE B 1 9   ? 37.675  4.997   -26.766 1.00 18.78 ? 9    ILE B CA  1 ? 
ATOM   2381 C C   . ILE B 1 9   ? 36.526  4.504   -27.651 1.00 18.22 ? 9    ILE B C   1 ? 
ATOM   2382 O O   . ILE B 1 9   ? 35.442  4.239   -27.103 1.00 20.28 ? 9    ILE B O   1 ? 
ATOM   2383 C CB  . ILE B 1 9   ? 37.775  6.534   -26.763 1.00 20.99 ? 9    ILE B CB  1 ? 
ATOM   2384 C CG1 . ILE B 1 9   ? 38.771  7.014   -25.714 1.00 23.51 ? 9    ILE B CG1 1 ? 
ATOM   2385 C CG2 . ILE B 1 9   ? 36.405  7.160   -26.515 1.00 21.90 ? 9    ILE B CG2 1 ? 
ATOM   2386 C CD1 . ILE B 1 9   ? 39.218  8.449   -25.909 1.00 25.76 ? 9    ILE B CD1 1 ? 
ATOM   2387 N N   . VAL B 1 10  ? 36.723  4.397   -28.964 1.00 17.66 ? 10   VAL B N   1 ? 
ATOM   2388 C CA  . VAL B 1 10  ? 35.678  3.870   -29.889 1.00 16.59 ? 10   VAL B CA  1 ? 
ATOM   2389 C C   . VAL B 1 10  ? 35.279  2.470   -29.431 1.00 17.20 ? 10   VAL B C   1 ? 
ATOM   2390 O O   . VAL B 1 10  ? 34.075  2.172   -29.348 1.00 18.08 ? 10   VAL B O   1 ? 
ATOM   2391 C CB  . VAL B 1 10  ? 36.165  3.864   -31.342 1.00 17.55 ? 10   VAL B CB  1 ? 
ATOM   2392 C CG1 . VAL B 1 10  ? 35.258  3.053   -32.260 1.00 17.47 ? 10   VAL B CG1 1 ? 
ATOM   2393 C CG2 . VAL B 1 10  ? 36.339  5.287   -31.851 1.00 17.93 ? 10   VAL B CG2 1 ? 
ATOM   2394 N N   . ASN B 1 11  ? 36.254  1.624   -29.133 1.00 16.69 ? 11   ASN B N   1 ? 
ATOM   2395 C CA  . ASN B 1 11  ? 35.985  0.241   -28.687 1.00 16.70 ? 11   ASN B CA  1 ? 
ATOM   2396 C C   . ASN B 1 11  ? 35.128  0.266   -27.410 1.00 16.98 ? 11   ASN B C   1 ? 
ATOM   2397 O O   . ASN B 1 11  ? 34.063  -0.407  -27.356 1.00 16.71 ? 11   ASN B O   1 ? 
ATOM   2398 C CB  . ASN B 1 11  ? 37.317  -0.482  -28.493 1.00 16.71 ? 11   ASN B CB  1 ? 
ATOM   2399 C CG  . ASN B 1 11  ? 37.138  -1.968  -28.334 1.00 18.76 ? 11   ASN B CG  1 ? 
ATOM   2400 O OD1 . ASN B 1 11  ? 36.180  -2.420  -27.727 1.00 19.17 ? 11   ASN B OD1 1 ? 
ATOM   2401 N ND2 . ASN B 1 11  ? 38.092  -2.725  -28.832 1.00 20.61 ? 11   ASN B ND2 1 ? 
ATOM   2402 N N   . LEU B 1 12  ? 35.522  1.054   -26.415 1.00 16.58 ? 12   LEU B N   1 ? 
ATOM   2403 C CA  . LEU B 1 12  ? 34.795  1.113   -25.130 1.00 17.58 ? 12   LEU B CA  1 ? 
ATOM   2404 C C   . LEU B 1 12  ? 33.372  1.631   -25.379 1.00 17.80 ? 12   LEU B C   1 ? 
ATOM   2405 O O   . LEU B 1 12  ? 32.420  1.098   -24.762 1.00 18.61 ? 12   LEU B O   1 ? 
ATOM   2406 C CB  . LEU B 1 12  ? 35.581  1.994   -24.157 1.00 18.14 ? 12   LEU B CB  1 ? 
ATOM   2407 C CG  . LEU B 1 12  ? 36.927  1.418   -23.691 1.00 20.29 ? 12   LEU B CG  1 ? 
ATOM   2408 C CD1 . LEU B 1 12  ? 37.693  2.458   -22.892 1.00 22.93 ? 12   LEU B CD1 1 ? 
ATOM   2409 C CD2 . LEU B 1 12  ? 36.751  0.159   -22.853 1.00 21.00 ? 12   LEU B CD2 1 ? 
ATOM   2410 N N   . LEU B 1 13  ? 33.197  2.645   -26.218 1.00 18.40 ? 13   LEU B N   1 ? 
ATOM   2411 C CA  . LEU B 1 13  ? 31.838  3.203   -26.484 1.00 18.46 ? 13   LEU B CA  1 ? 
ATOM   2412 C C   . LEU B 1 13  ? 30.961  2.175   -27.202 1.00 18.30 ? 13   LEU B C   1 ? 
ATOM   2413 O O   . LEU B 1 13  ? 29.758  2.114   -26.893 1.00 18.50 ? 13   LEU B O   1 ? 
ATOM   2414 C CB  . LEU B 1 13  ? 31.951  4.482   -27.306 1.00 19.45 ? 13   LEU B CB  1 ? 
ATOM   2415 C CG  . LEU B 1 13  ? 32.540  5.677   -26.573 1.00 22.15 ? 13   LEU B CG  1 ? 
ATOM   2416 C CD1 . LEU B 1 13  ? 32.745  6.811   -27.570 1.00 22.19 ? 13   LEU B CD1 1 ? 
ATOM   2417 C CD2 . LEU B 1 13  ? 31.656  6.108   -25.420 1.00 24.74 ? 13   LEU B CD2 1 ? 
ATOM   2418 N N   . ARG B 1 14  ? 31.512  1.381   -28.124 1.00 18.04 ? 14   ARG B N   1 ? 
ATOM   2419 C CA  . ARG B 1 14  ? 30.734  0.319   -28.819 1.00 17.22 ? 14   ARG B CA  1 ? 
ATOM   2420 C C   . ARG B 1 14  ? 30.202  -0.710  -27.811 1.00 17.38 ? 14   ARG B C   1 ? 
ATOM   2421 O O   . ARG B 1 14  ? 29.154  -1.327  -28.092 1.00 17.60 ? 14   ARG B O   1 ? 
ATOM   2422 C CB  . ARG B 1 14  ? 31.581  -0.357  -29.895 1.00 18.08 ? 14   ARG B CB  1 ? 
ATOM   2423 C CG  . ARG B 1 14  ? 31.869  0.541   -31.087 1.00 19.81 ? 14   ARG B CG  1 ? 
ATOM   2424 C CD  . ARG B 1 14  ? 32.766  -0.112  -32.113 1.00 21.37 ? 14   ARG B CD  1 ? 
ATOM   2425 N NE  . ARG B 1 14  ? 32.081  -1.162  -32.855 1.00 24.40 ? 14   ARG B NE  1 ? 
ATOM   2426 C CZ  . ARG B 1 14  ? 32.674  -2.209  -33.445 1.00 25.59 ? 14   ARG B CZ  1 ? 
ATOM   2427 N NH1 . ARG B 1 14  ? 33.989  -2.366  -33.417 1.00 27.79 ? 14   ARG B NH1 1 ? 
ATOM   2428 N NH2 . ARG B 1 14  ? 31.941  -3.092  -34.086 1.00 25.96 ? 14   ARG B NH2 1 ? 
ATOM   2429 N N   . SER B 1 15  ? 30.893  -0.912  -26.690 1.00 16.45 ? 15   SER B N   1 ? 
ATOM   2430 C CA  . SER B 1 15  ? 30.474  -1.819  -25.598 1.00 16.25 ? 15   SER B CA  1 ? 
ATOM   2431 C C   . SER B 1 15  ? 29.464  -1.145  -24.662 1.00 16.82 ? 15   SER B C   1 ? 
ATOM   2432 O O   . SER B 1 15  ? 28.528  -1.797  -24.266 1.00 18.25 ? 15   SER B O   1 ? 
ATOM   2433 C CB  . SER B 1 15  ? 31.680  -2.314  -24.824 1.00 16.06 ? 15   SER B CB  1 ? 
ATOM   2434 O OG  . SER B 1 15  ? 32.516  -3.107  -25.647 1.00 16.79 ? 15   SER B OG  1 ? 
ATOM   2435 N N   A GLN B 1 16  ? 29.691  0.116   -24.296 0.50 17.56 ? 16   GLN B N   1 ? 
ATOM   2436 N N   B GLN B 1 16  ? 29.666  0.136   -24.329 0.50 16.76 ? 16   GLN B N   1 ? 
ATOM   2437 C CA  A GLN B 1 16  ? 28.820  0.847   -23.340 0.50 18.86 ? 16   GLN B CA  1 ? 
ATOM   2438 C CA  B GLN B 1 16  ? 28.832  0.871   -23.333 0.50 17.54 ? 16   GLN B CA  1 ? 
ATOM   2439 C C   A GLN B 1 16  ? 27.464  1.155   -23.991 0.50 18.95 ? 16   GLN B C   1 ? 
ATOM   2440 C C   B GLN B 1 16  ? 27.483  1.251   -23.954 0.50 17.78 ? 16   GLN B C   1 ? 
ATOM   2441 O O   A GLN B 1 16  ? 26.430  0.910   -23.342 0.50 18.86 ? 16   GLN B O   1 ? 
ATOM   2442 O O   B GLN B 1 16  ? 26.489  1.232   -23.222 0.50 15.87 ? 16   GLN B O   1 ? 
ATOM   2443 C CB  A GLN B 1 16  ? 29.521  2.122   -22.876 0.50 21.14 ? 16   GLN B CB  1 ? 
ATOM   2444 C CB  B GLN B 1 16  ? 29.524  2.147   -22.840 0.50 19.19 ? 16   GLN B CB  1 ? 
ATOM   2445 C CG  A GLN B 1 16  ? 29.003  2.625   -21.546 0.50 23.14 ? 16   GLN B CG  1 ? 
ATOM   2446 C CG  B GLN B 1 16  ? 30.628  1.914   -21.815 0.50 19.93 ? 16   GLN B CG  1 ? 
ATOM   2447 C CD  A GLN B 1 16  ? 29.137  1.547   -20.504 0.50 24.01 ? 16   GLN B CD  1 ? 
ATOM   2448 C CD  B GLN B 1 16  ? 31.637  3.040   -21.743 0.50 22.74 ? 16   GLN B CD  1 ? 
ATOM   2449 O OE1 A GLN B 1 16  ? 28.184  0.849   -20.184 0.50 26.75 ? 16   GLN B OE1 1 ? 
ATOM   2450 O OE1 B GLN B 1 16  ? 32.028  3.497   -20.668 0.50 26.14 ? 16   GLN B OE1 1 ? 
ATOM   2451 N NE2 A GLN B 1 16  ? 30.351  1.353   -20.031 0.50 25.49 ? 16   GLN B NE2 1 ? 
ATOM   2452 N NE2 B GLN B 1 16  ? 32.102  3.484   -22.899 0.50 25.38 ? 16   GLN B NE2 1 ? 
ATOM   2453 N N   . ARG B 1 17  ? 27.474  1.685   -25.220 1.00 19.03 ? 17   ARG B N   1 ? 
ATOM   2454 C CA  . ARG B 1 17  ? 26.227  1.963   -25.987 1.00 18.81 ? 17   ARG B CA  1 ? 
ATOM   2455 C C   . ARG B 1 17  ? 25.175  2.647   -25.111 1.00 19.06 ? 17   ARG B C   1 ? 
ATOM   2456 O O   . ARG B 1 17  ? 24.070  2.139   -24.959 1.00 18.52 ? 17   ARG B O   1 ? 
ATOM   2457 C CB  . ARG B 1 17  ? 25.600  0.633   -26.436 1.00 20.57 ? 17   ARG B CB  1 ? 
ATOM   2458 C CG  . ARG B 1 17  ? 26.448  -0.266  -27.304 1.00 21.54 ? 17   ARG B CG  1 ? 
ATOM   2459 C CD  . ARG B 1 17  ? 25.637  -1.466  -27.752 1.00 19.37 ? 17   ARG B CD  1 ? 
ATOM   2460 N NE  . ARG B 1 17  ? 25.446  -2.545  -26.784 1.00 17.06 ? 17   ARG B NE  1 ? 
ATOM   2461 C CZ  . ARG B 1 17  ? 26.352  -3.478  -26.514 1.00 16.80 ? 17   ARG B CZ  1 ? 
ATOM   2462 N NH1 . ARG B 1 17  ? 27.548  -3.448  -27.082 1.00 16.06 ? 17   ARG B NH1 1 ? 
ATOM   2463 N NH2 . ARG B 1 17  ? 26.070  -4.461  -25.677 1.00 17.23 ? 17   ARG B NH2 1 ? 
ATOM   2464 N N   . PRO B 1 18  ? 25.424  3.817   -24.495 1.00 20.46 ? 18   PRO B N   1 ? 
ATOM   2465 C CA  . PRO B 1 18  ? 24.457  4.351   -23.539 1.00 20.56 ? 18   PRO B CA  1 ? 
ATOM   2466 C C   . PRO B 1 18  ? 23.091  4.721   -24.138 1.00 20.27 ? 18   PRO B C   1 ? 
ATOM   2467 O O   . PRO B 1 18  ? 22.123  4.619   -23.431 1.00 21.85 ? 18   PRO B O   1 ? 
ATOM   2468 C CB  . PRO B 1 18  ? 25.198  5.574   -22.973 1.00 22.58 ? 18   PRO B CB  1 ? 
ATOM   2469 C CG  . PRO B 1 18  ? 26.102  5.980   -24.100 1.00 21.42 ? 18   PRO B CG  1 ? 
ATOM   2470 C CD  . PRO B 1 18  ? 26.612  4.671   -24.670 1.00 22.77 ? 18   PRO B CD  1 ? 
ATOM   2471 N N   . LEU B 1 19  ? 23.006  5.047   -25.432 1.00 17.76 ? 19   LEU B N   1 ? 
ATOM   2472 C CA  . LEU B 1 19  ? 21.694  5.368   -26.067 1.00 18.80 ? 19   LEU B CA  1 ? 
ATOM   2473 C C   . LEU B 1 19  ? 20.878  4.107   -26.362 1.00 17.88 ? 19   LEU B C   1 ? 
ATOM   2474 O O   . LEU B 1 19  ? 19.684  4.259   -26.767 1.00 19.14 ? 19   LEU B O   1 ? 
ATOM   2475 C CB  . LEU B 1 19  ? 21.936  6.149   -27.363 1.00 19.83 ? 19   LEU B CB  1 ? 
ATOM   2476 C CG  . LEU B 1 19  ? 22.552  7.531   -27.197 1.00 21.58 ? 19   LEU B CG  1 ? 
ATOM   2477 C CD1 . LEU B 1 19  ? 22.510  8.259   -28.540 1.00 23.46 ? 19   LEU B CD1 1 ? 
ATOM   2478 C CD2 . LEU B 1 19  ? 21.839  8.350   -26.123 1.00 22.28 ? 19   LEU B CD2 1 ? 
ATOM   2479 N N   . GLN B 1 20  ? 21.442  2.918   -26.160 1.00 17.13 ? 20   GLN B N   1 ? 
ATOM   2480 C CA  . GLN B 1 20  ? 20.715  1.653   -26.447 1.00 17.10 ? 20   GLN B CA  1 ? 
ATOM   2481 C C   . GLN B 1 20  ? 20.244  1.014   -25.134 1.00 17.18 ? 20   GLN B C   1 ? 
ATOM   2482 O O   . GLN B 1 20  ? 19.683  -0.078  -25.202 1.00 17.74 ? 20   GLN B O   1 ? 
ATOM   2483 C CB  . GLN B 1 20  ? 21.591  0.690   -27.240 1.00 19.55 ? 20   GLN B CB  1 ? 
ATOM   2484 C CG  . GLN B 1 20  ? 21.890  1.182   -28.655 1.00 22.20 ? 20   GLN B CG  1 ? 
ATOM   2485 C CD  . GLN B 1 20  ? 22.647  0.145   -29.452 1.00 26.44 ? 20   GLN B CD  1 ? 
ATOM   2486 O OE1 . GLN B 1 20  ? 22.230  -1.008  -29.565 1.00 33.81 ? 20   GLN B OE1 1 ? 
ATOM   2487 N NE2 . GLN B 1 20  ? 23.780  0.541   -30.000 1.00 30.51 ? 20   GLN B NE2 1 ? 
ATOM   2488 N N   . GLU B 1 21  ? 20.380  1.691   -23.992 1.00 15.86 ? 21   GLU B N   1 ? 
ATOM   2489 C CA  . GLU B 1 21  ? 19.790  1.198   -22.713 1.00 15.95 ? 21   GLU B CA  1 ? 
ATOM   2490 C C   . GLU B 1 21  ? 18.266  1.125   -22.817 1.00 15.31 ? 21   GLU B C   1 ? 
ATOM   2491 O O   . GLU B 1 21  ? 17.596  1.865   -23.540 1.00 16.10 ? 21   GLU B O   1 ? 
ATOM   2492 C CB  . GLU B 1 21  ? 20.217  2.089   -21.560 1.00 15.85 ? 21   GLU B CB  1 ? 
ATOM   2493 C CG  . GLU B 1 21  ? 21.677  1.927   -21.205 1.00 17.66 ? 21   GLU B CG  1 ? 
ATOM   2494 C CD  . GLU B 1 21  ? 22.027  0.597   -20.541 1.00 20.49 ? 21   GLU B CD  1 ? 
ATOM   2495 O OE1 . GLU B 1 21  ? 21.123  -0.025  -19.957 1.00 23.31 ? 21   GLU B OE1 1 ? 
ATOM   2496 O OE2 . GLU B 1 21  ? 23.210  0.205   -20.581 1.00 24.35 ? 21   GLU B OE2 1 ? 
ATOM   2497 N N   . PRO B 1 22  ? 17.647  0.144   -22.129 1.00 15.23 ? 22   PRO B N   1 ? 
ATOM   2498 C CA  . PRO B 1 22  ? 16.251  -0.192  -22.409 1.00 15.75 ? 22   PRO B CA  1 ? 
ATOM   2499 C C   . PRO B 1 22  ? 15.199  0.795   -21.915 1.00 16.68 ? 22   PRO B C   1 ? 
ATOM   2500 O O   . PRO B 1 22  ? 14.108  0.763   -22.431 1.00 20.61 ? 22   PRO B O   1 ? 
ATOM   2501 C CB  . PRO B 1 22  ? 16.059  -1.561  -21.739 1.00 15.49 ? 22   PRO B CB  1 ? 
ATOM   2502 C CG  . PRO B 1 22  ? 17.165  -1.667  -20.749 1.00 15.98 ? 22   PRO B CG  1 ? 
ATOM   2503 C CD  . PRO B 1 22  ? 18.318  -0.843  -21.283 1.00 15.66 ? 22   PRO B CD  1 ? 
ATOM   2504 N N   . THR B 1 23  ? 15.540  1.652   -20.961 1.00 15.09 ? 23   THR B N   1 ? 
ATOM   2505 C CA  . THR B 1 23  ? 14.605  2.633   -20.368 1.00 16.02 ? 23   THR B CA  1 ? 
ATOM   2506 C C   . THR B 1 23  ? 15.296  3.985   -20.275 1.00 15.84 ? 23   THR B C   1 ? 
ATOM   2507 O O   . THR B 1 23  ? 16.521  4.013   -20.257 1.00 16.03 ? 23   THR B O   1 ? 
ATOM   2508 C CB  . THR B 1 23  ? 14.126  2.256   -18.959 1.00 16.73 ? 23   THR B CB  1 ? 
ATOM   2509 O OG1 . THR B 1 23  ? 15.230  2.371   -18.054 1.00 19.20 ? 23   THR B OG1 1 ? 
ATOM   2510 C CG2 . THR B 1 23  ? 13.508  0.875   -18.885 1.00 17.28 ? 23   THR B CG2 1 ? 
ATOM   2511 N N   . VAL B 1 24  ? 14.495  5.033   -20.170 1.00 16.09 ? 24   VAL B N   1 ? 
ATOM   2512 C CA  . VAL B 1 24  ? 15.005  6.421   -19.937 1.00 17.02 ? 24   VAL B CA  1 ? 
ATOM   2513 C C   . VAL B 1 24  ? 15.942  6.446   -18.720 1.00 16.52 ? 24   VAL B C   1 ? 
ATOM   2514 O O   . VAL B 1 24  ? 17.060  7.006   -18.815 1.00 15.83 ? 24   VAL B O   1 ? 
ATOM   2515 C CB  . VAL B 1 24  ? 13.809  7.366   -19.745 1.00 18.71 ? 24   VAL B CB  1 ? 
ATOM   2516 C CG1 . VAL B 1 24  ? 14.272  8.742   -19.287 1.00 20.89 ? 24   VAL B CG1 1 ? 
ATOM   2517 C CG2 . VAL B 1 24  ? 13.001  7.459   -21.028 1.00 21.10 ? 24   VAL B CG2 1 ? 
ATOM   2518 N N   . GLU B 1 25  ? 15.533  5.852   -17.598 1.00 16.66 ? 25   GLU B N   1 ? 
ATOM   2519 C CA  . GLU B 1 25  ? 16.348  5.939   -16.356 1.00 16.69 ? 25   GLU B CA  1 ? 
ATOM   2520 C C   . GLU B 1 25  ? 17.661  5.176   -16.550 1.00 15.69 ? 25   GLU B C   1 ? 
ATOM   2521 O O   . GLU B 1 25  ? 18.678  5.629   -16.032 1.00 15.50 ? 25   GLU B O   1 ? 
ATOM   2522 C CB  . GLU B 1 25  ? 15.582  5.430   -15.132 1.00 17.42 ? 25   GLU B CB  1 ? 
ATOM   2523 C CG  . GLU B 1 25  ? 14.365  6.260   -14.796 1.00 18.40 ? 25   GLU B CG  1 ? 
ATOM   2524 C CD  . GLU B 1 25  ? 13.132  6.032   -15.662 1.00 20.86 ? 25   GLU B CD  1 ? 
ATOM   2525 O OE1 . GLU B 1 25  ? 12.174  6.786   -15.438 1.00 24.35 ? 25   GLU B OE1 1 ? 
ATOM   2526 O OE2 . GLU B 1 25  ? 13.106  5.110   -16.562 1.00 20.70 ? 25   GLU B OE2 1 ? 
ATOM   2527 N N   . GLN B 1 26  ? 17.658  4.063   -17.287 1.00 15.94 ? 26   GLN B N   1 ? 
ATOM   2528 C CA  . GLN B 1 26  ? 18.914  3.314   -17.547 1.00 15.80 ? 26   GLN B CA  1 ? 
ATOM   2529 C C   . GLN B 1 26  ? 19.808  4.107   -18.508 1.00 16.03 ? 26   GLN B C   1 ? 
ATOM   2530 O O   . GLN B 1 26  ? 21.027  4.059   -18.333 1.00 17.65 ? 26   GLN B O   1 ? 
ATOM   2531 C CB  . GLN B 1 26  ? 18.620  1.877   -17.982 1.00 17.22 ? 26   GLN B CB  1 ? 
ATOM   2532 C CG  . GLN B 1 26  ? 18.078  1.081   -16.795 1.00 18.59 ? 26   GLN B CG  1 ? 
ATOM   2533 C CD  . GLN B 1 26  ? 17.659  -0.301  -17.206 1.00 19.86 ? 26   GLN B CD  1 ? 
ATOM   2534 O OE1 . GLN B 1 26  ? 18.495  -1.073  -17.659 1.00 21.49 ? 26   GLN B OE1 1 ? 
ATOM   2535 N NE2 . GLN B 1 26  ? 16.372  -0.627  -17.070 1.00 21.45 ? 26   GLN B NE2 1 ? 
ATOM   2536 N N   A MET B 1 27  ? 19.231  4.836   -19.460 0.50 16.84 ? 27   MET B N   1 ? 
ATOM   2537 N N   B MET B 1 27  ? 19.225  4.811   -19.479 0.50 15.93 ? 27   MET B N   1 ? 
ATOM   2538 C CA  A MET B 1 27  ? 20.031  5.705   -20.362 0.50 16.87 ? 27   MET B CA  1 ? 
ATOM   2539 C CA  B MET B 1 27  ? 19.990  5.710   -20.385 0.50 15.43 ? 27   MET B CA  1 ? 
ATOM   2540 C C   A MET B 1 27  ? 20.665  6.821   -19.533 0.50 15.45 ? 27   MET B C   1 ? 
ATOM   2541 C C   B MET B 1 27  ? 20.653  6.805   -19.543 0.50 14.66 ? 27   MET B C   1 ? 
ATOM   2542 O O   A MET B 1 27  ? 21.873  7.093   -19.724 0.50 15.73 ? 27   MET B O   1 ? 
ATOM   2543 O O   B MET B 1 27  ? 21.863  7.048   -19.760 0.50 14.95 ? 27   MET B O   1 ? 
ATOM   2544 C CB  A MET B 1 27  ? 19.168  6.300   -21.471 0.50 18.32 ? 27   MET B CB  1 ? 
ATOM   2545 C CB  B MET B 1 27  ? 19.086  6.361   -21.434 0.50 15.68 ? 27   MET B CB  1 ? 
ATOM   2546 C CG  A MET B 1 27  ? 18.930  5.340   -22.612 0.50 20.66 ? 27   MET B CG  1 ? 
ATOM   2547 C CG  B MET B 1 27  ? 18.454  5.377   -22.404 0.50 16.58 ? 27   MET B CG  1 ? 
ATOM   2548 S SD  A MET B 1 27  ? 18.336  6.192   -24.088 0.50 24.09 ? 27   MET B SD  1 ? 
ATOM   2549 S SD  B MET B 1 27  ? 17.199  6.149   -23.441 0.50 18.50 ? 27   MET B SD  1 ? 
ATOM   2550 C CE  A MET B 1 27  ? 16.601  5.753   -24.020 0.50 25.31 ? 27   MET B CE  1 ? 
ATOM   2551 C CE  B MET B 1 27  ? 18.184  7.334   -24.351 0.50 19.57 ? 27   MET B CE  1 ? 
ATOM   2552 N N   . ARG B 1 28  ? 19.891  7.438   -18.646 1.00 14.19 ? 28   ARG B N   1 ? 
ATOM   2553 C CA  . ARG B 1 28  ? 20.411  8.530   -17.782 1.00 15.04 ? 28   ARG B CA  1 ? 
ATOM   2554 C C   . ARG B 1 28  ? 21.566  7.984   -16.951 1.00 15.32 ? 28   ARG B C   1 ? 
ATOM   2555 O O   . ARG B 1 28  ? 22.632  8.636   -16.881 1.00 17.32 ? 28   ARG B O   1 ? 
ATOM   2556 C CB  . ARG B 1 28  ? 19.294  9.114   -16.925 1.00 14.56 ? 28   ARG B CB  1 ? 
ATOM   2557 C CG  . ARG B 1 28  ? 18.254  9.865   -17.737 1.00 15.29 ? 28   ARG B CG  1 ? 
ATOM   2558 C CD  . ARG B 1 28  ? 17.137  10.470  -16.918 1.00 14.72 ? 28   ARG B CD  1 ? 
ATOM   2559 N NE  . ARG B 1 28  ? 16.272  11.234  -17.803 1.00 14.52 ? 28   ARG B NE  1 ? 
ATOM   2560 C CZ  . ARG B 1 28  ? 14.988  11.495  -17.596 1.00 14.67 ? 28   ARG B CZ  1 ? 
ATOM   2561 N NH1 . ARG B 1 28  ? 14.381  11.089  -16.492 1.00 16.00 ? 28   ARG B NH1 1 ? 
ATOM   2562 N NH2 . ARG B 1 28  ? 14.307  12.188  -18.478 1.00 14.29 ? 28   ARG B NH2 1 ? 
ATOM   2563 N N   . ALA B 1 29  ? 21.377  6.827   -16.310 1.00 16.76 ? 29   ALA B N   1 ? 
ATOM   2564 C CA  . ALA B 1 29  ? 22.395  6.215   -15.426 1.00 18.35 ? 29   ALA B CA  1 ? 
ATOM   2565 C C   . ALA B 1 29  ? 23.626  5.811   -16.241 1.00 18.26 ? 29   ALA B C   1 ? 
ATOM   2566 O O   . ALA B 1 29  ? 24.746  5.949   -15.690 1.00 19.75 ? 29   ALA B O   1 ? 
ATOM   2567 C CB  . ALA B 1 29  ? 21.797  5.033   -14.689 1.00 17.92 ? 29   ALA B CB  1 ? 
ATOM   2568 N N   . GLY B 1 30  ? 23.455  5.344   -17.482 1.00 18.80 ? 30   GLY B N   1 ? 
ATOM   2569 C CA  . GLY B 1 30  ? 24.563  4.940   -18.373 1.00 18.48 ? 30   GLY B CA  1 ? 
ATOM   2570 C C   . GLY B 1 30  ? 25.460  6.133   -18.680 1.00 19.14 ? 30   GLY B C   1 ? 
ATOM   2571 O O   . GLY B 1 30  ? 26.719  6.010   -18.627 1.00 20.45 ? 30   GLY B O   1 ? 
ATOM   2572 N N   . LEU B 1 31  ? 24.870  7.288   -18.979 1.00 18.24 ? 31   LEU B N   1 ? 
ATOM   2573 C CA  . LEU B 1 31  ? 25.719  8.476   -19.249 1.00 17.51 ? 31   LEU B CA  1 ? 
ATOM   2574 C C   . LEU B 1 31  ? 26.414  8.938   -17.964 1.00 17.79 ? 31   LEU B C   1 ? 
ATOM   2575 O O   . LEU B 1 31  ? 27.559  9.384   -18.059 1.00 18.10 ? 31   LEU B O   1 ? 
ATOM   2576 C CB  . LEU B 1 31  ? 24.888  9.610   -19.839 1.00 17.29 ? 31   LEU B CB  1 ? 
ATOM   2577 C CG  . LEU B 1 31  ? 25.721  10.737  -20.456 1.00 18.61 ? 31   LEU B CG  1 ? 
ATOM   2578 C CD1 . LEU B 1 31  ? 26.604  10.223  -21.584 1.00 20.11 ? 31   LEU B CD1 1 ? 
ATOM   2579 C CD2 . LEU B 1 31  ? 24.804  11.846  -20.954 1.00 18.01 ? 31   LEU B CD2 1 ? 
ATOM   2580 N N   . GLU B 1 32  ? 25.751  8.884   -16.809 1.00 18.06 ? 32   GLU B N   1 ? 
ATOM   2581 C CA  . GLU B 1 32  ? 26.354  9.312   -15.519 1.00 20.44 ? 32   GLU B CA  1 ? 
ATOM   2582 C C   . GLU B 1 32  ? 27.570  8.412   -15.241 1.00 21.49 ? 32   GLU B C   1 ? 
ATOM   2583 O O   . GLU B 1 32  ? 28.635  8.933   -14.842 1.00 21.47 ? 32   GLU B O   1 ? 
ATOM   2584 C CB  . GLU B 1 32  ? 25.331  9.294   -14.380 1.00 20.99 ? 32   GLU B CB  1 ? 
ATOM   2585 C CG  . GLU B 1 32  ? 24.232  10.325  -14.507 1.00 23.41 ? 32   GLU B CG  1 ? 
ATOM   2586 C CD  . GLU B 1 32  ? 24.518  11.720  -13.981 1.00 27.98 ? 32   GLU B CD  1 ? 
ATOM   2587 O OE1 . GLU B 1 32  ? 23.576  12.561  -13.978 1.00 29.33 ? 32   GLU B OE1 1 ? 
ATOM   2588 O OE2 . GLU B 1 32  ? 25.668  11.963  -13.558 1.00 30.20 ? 32   GLU B OE2 1 ? 
ATOM   2589 N N   . ALA B 1 33  ? 27.446  7.114   -15.516 1.00 22.73 ? 33   ALA B N   1 ? 
ATOM   2590 C CA  . ALA B 1 33  ? 28.550  6.142   -15.331 1.00 23.44 ? 33   ALA B CA  1 ? 
ATOM   2591 C C   . ALA B 1 33  ? 29.735  6.516   -16.239 1.00 24.18 ? 33   ALA B C   1 ? 
ATOM   2592 O O   . ALA B 1 33  ? 30.899  6.506   -15.764 1.00 24.60 ? 33   ALA B O   1 ? 
ATOM   2593 C CB  . ALA B 1 33  ? 28.047  4.740   -15.586 1.00 24.76 ? 33   ALA B CB  1 ? 
ATOM   2594 N N   A MET B 1 34  ? 29.466  6.840   -17.506 0.50 23.73 ? 34   MET B N   1 ? 
ATOM   2595 N N   B MET B 1 34  ? 29.463  6.877   -17.492 0.50 25.13 ? 34   MET B N   1 ? 
ATOM   2596 C CA  A MET B 1 34  ? 30.493  7.242   -18.510 0.50 24.01 ? 34   MET B CA  1 ? 
ATOM   2597 C CA  B MET B 1 34  ? 30.511  7.250   -18.476 0.50 26.41 ? 34   MET B CA  1 ? 
ATOM   2598 C C   A MET B 1 34  ? 31.204  8.514   -18.010 0.50 24.69 ? 34   MET B C   1 ? 
ATOM   2599 C C   B MET B 1 34  ? 31.212  8.535   -18.041 0.50 26.15 ? 34   MET B C   1 ? 
ATOM   2600 O O   A MET B 1 34  ? 32.457  8.527   -17.971 0.50 24.14 ? 34   MET B O   1 ? 
ATOM   2601 O O   B MET B 1 34  ? 32.447  8.609   -18.212 0.50 25.57 ? 34   MET B O   1 ? 
ATOM   2602 C CB  A MET B 1 34  ? 29.843  7.465   -19.885 0.50 24.16 ? 34   MET B CB  1 ? 
ATOM   2603 C CB  B MET B 1 34  ? 29.914  7.488   -19.857 0.50 28.40 ? 34   MET B CB  1 ? 
ATOM   2604 C CG  A MET B 1 34  ? 30.808  7.633   -21.054 0.50 24.08 ? 34   MET B CG  1 ? 
ATOM   2605 C CG  B MET B 1 34  ? 29.441  6.240   -20.511 0.50 29.94 ? 34   MET B CG  1 ? 
ATOM   2606 S SD  A MET B 1 34  ? 29.995  7.730   -22.697 0.50 24.50 ? 34   MET B SD  1 ? 
ATOM   2607 S SD  B MET B 1 34  ? 28.776  6.686   -22.098 0.50 33.41 ? 34   MET B SD  1 ? 
ATOM   2608 C CE  A MET B 1 34  ? 29.484  6.023   -22.887 0.50 24.21 ? 34   MET B CE  1 ? 
ATOM   2609 C CE  B MET B 1 34  ? 30.105  7.720   -22.710 0.50 33.17 ? 34   MET B CE  1 ? 
ATOM   2610 N N   . ALA B 1 35  ? 30.447  9.520   -17.558 1.00 24.89 ? 35   ALA B N   1 ? 
ATOM   2611 C CA  . ALA B 1 35  ? 30.990  10.840  -17.158 1.00 25.52 ? 35   ALA B CA  1 ? 
ATOM   2612 C C   . ALA B 1 35  ? 31.942  10.694  -15.965 1.00 28.31 ? 35   ALA B C   1 ? 
ATOM   2613 O O   . ALA B 1 35  ? 32.963  11.390  -15.966 1.00 28.15 ? 35   ALA B O   1 ? 
ATOM   2614 C CB  . ALA B 1 35  ? 29.870  11.808  -16.851 1.00 24.54 ? 35   ALA B CB  1 ? 
ATOM   2615 N N   . GLN B 1 36  ? 31.631  9.822   -14.993 1.00 31.93 ? 36   GLN B N   1 ? 
ATOM   2616 C CA  . GLN B 1 36  ? 32.439  9.630   -13.751 1.00 34.59 ? 36   GLN B CA  1 ? 
ATOM   2617 C C   . GLN B 1 36  ? 33.851  9.136   -14.088 1.00 35.83 ? 36   GLN B C   1 ? 
ATOM   2618 O O   . GLN B 1 36  ? 34.715  9.193   -13.185 1.00 39.29 ? 36   GLN B O   1 ? 
ATOM   2619 C CB  . GLN B 1 36  ? 31.761  8.670   -12.769 1.00 39.87 ? 36   GLN B CB  1 ? 
ATOM   2620 C CG  . GLN B 1 36  ? 30.722  9.344   -11.877 1.00 45.50 ? 36   GLN B CG  1 ? 
ATOM   2621 C CD  . GLN B 1 36  ? 29.596  8.435   -11.432 1.00 54.59 ? 36   GLN B CD  1 ? 
ATOM   2622 O OE1 . GLN B 1 36  ? 29.395  7.340   -11.963 1.00 62.57 ? 36   GLN B OE1 1 ? 
ATOM   2623 N NE2 . GLN B 1 36  ? 28.829  8.890   -10.450 1.00 57.26 ? 36   GLN B NE2 1 ? 
ATOM   2624 N N   . MET B 1 37  ? 34.114  8.717   -15.330 1.00 33.14 ? 37   MET B N   1 ? 
ATOM   2625 C CA  . MET B 1 37  ? 35.465  8.269   -15.765 1.00 35.32 ? 37   MET B CA  1 ? 
ATOM   2626 C C   . MET B 1 37  ? 36.426  9.457   -15.933 1.00 37.06 ? 37   MET B C   1 ? 
ATOM   2627 O O   . MET B 1 37  ? 37.647  9.232   -15.829 1.00 40.27 ? 37   MET B O   1 ? 
ATOM   2628 C CB  . MET B 1 37  ? 35.359  7.496   -17.079 1.00 35.65 ? 37   MET B CB  1 ? 
ATOM   2629 C CG  . MET B 1 37  ? 34.627  6.160   -16.906 1.00 38.15 ? 37   MET B CG  1 ? 
ATOM   2630 S SD  . MET B 1 37  ? 35.366  5.054   -15.628 1.00 41.64 ? 37   MET B SD  1 ? 
ATOM   2631 C CE  . MET B 1 37  ? 37.047  4.926   -16.237 1.00 40.60 ? 37   MET B CE  1 ? 
ATOM   2632 N N   . SER B 1 38  ? 35.904  10.658  -16.206 1.00 36.52 ? 38   SER B N   1 ? 
ATOM   2633 C CA  . SER B 1 38  ? 36.678  11.921  -16.340 1.00 36.47 ? 38   SER B CA  1 ? 
ATOM   2634 C C   . SER B 1 38  ? 36.400  12.802  -15.126 1.00 41.68 ? 38   SER B C   1 ? 
ATOM   2635 O O   . SER B 1 38  ? 35.584  13.722  -15.200 1.00 45.99 ? 38   SER B O   1 ? 
ATOM   2636 C CB  . SER B 1 38  ? 36.344  12.633  -17.630 1.00 35.46 ? 38   SER B CB  1 ? 
ATOM   2637 O OG  . SER B 1 38  ? 37.168  13.776  -17.803 1.00 35.83 ? 38   SER B OG  1 ? 
ATOM   2638 N N   . PRO B 1 39  ? 37.119  12.593  -14.001 1.00 44.78 ? 39   PRO B N   1 ? 
ATOM   2639 C CA  . PRO B 1 39  ? 36.805  13.261  -12.738 1.00 47.25 ? 39   PRO B CA  1 ? 
ATOM   2640 C C   . PRO B 1 39  ? 37.377  14.688  -12.675 1.00 45.39 ? 39   PRO B C   1 ? 
ATOM   2641 O O   . PRO B 1 39  ? 38.425  14.906  -13.257 1.00 43.12 ? 39   PRO B O   1 ? 
ATOM   2642 C CB  . PRO B 1 39  ? 37.495  12.330  -11.731 1.00 47.97 ? 39   PRO B CB  1 ? 
ATOM   2643 C CG  . PRO B 1 39  ? 38.760  11.906  -12.454 1.00 47.15 ? 39   PRO B CG  1 ? 
ATOM   2644 C CD  . PRO B 1 39  ? 38.365  11.813  -13.916 1.00 47.96 ? 39   PRO B CD  1 ? 
ATOM   2645 N N   . LEU B 1 40  ? 36.681  15.608  -11.987 1.00 44.58 ? 40   LEU B N   1 ? 
ATOM   2646 C CA  . LEU B 1 40  ? 37.025  17.057  -11.921 1.00 41.29 ? 40   LEU B CA  1 ? 
ATOM   2647 C C   . LEU B 1 40  ? 38.439  17.253  -11.377 1.00 40.16 ? 40   LEU B C   1 ? 
ATOM   2648 O O   . LEU B 1 40  ? 38.804  16.645  -10.377 1.00 42.88 ? 40   LEU B O   1 ? 
ATOM   2649 C CB  . LEU B 1 40  ? 36.045  17.800  -11.007 1.00 42.00 ? 40   LEU B CB  1 ? 
ATOM   2650 C CG  . LEU B 1 40  ? 34.709  18.236  -11.605 1.00 41.25 ? 40   LEU B CG  1 ? 
ATOM   2651 C CD1 . LEU B 1 40  ? 34.063  19.287  -10.708 1.00 41.86 ? 40   LEU B CD1 1 ? 
ATOM   2652 C CD2 . LEU B 1 40  ? 34.847  18.764  -13.032 1.00 40.28 ? 40   LEU B CD2 1 ? 
ATOM   2653 N N   . PRO B 1 41  ? 39.256  18.137  -11.993 1.00 35.08 ? 41   PRO B N   1 ? 
ATOM   2654 C CA  . PRO B 1 41  ? 40.430  18.696  -11.330 1.00 33.45 ? 41   PRO B CA  1 ? 
ATOM   2655 C C   . PRO B 1 41  ? 40.063  19.362  -9.996  1.00 33.02 ? 41   PRO B C   1 ? 
ATOM   2656 O O   . PRO B 1 41  ? 38.957  19.863  -9.851  1.00 32.16 ? 41   PRO B O   1 ? 
ATOM   2657 C CB  . PRO B 1 41  ? 40.947  19.747  -12.324 1.00 34.81 ? 41   PRO B CB  1 ? 
ATOM   2658 C CG  . PRO B 1 41  ? 40.468  19.238  -13.664 1.00 35.14 ? 41   PRO B CG  1 ? 
ATOM   2659 C CD  . PRO B 1 41  ? 39.118  18.612  -13.377 1.00 34.82 ? 41   PRO B CD  1 ? 
ATOM   2660 N N   . ALA B 1 42  ? 41.019  19.384  -9.067  1.00 33.60 ? 42   ALA B N   1 ? 
ATOM   2661 C CA  . ALA B 1 42  ? 40.847  19.905  -7.694  1.00 33.12 ? 42   ALA B CA  1 ? 
ATOM   2662 C C   . ALA B 1 42  ? 40.555  21.414  -7.701  1.00 32.07 ? 42   ALA B C   1 ? 
ATOM   2663 O O   . ALA B 1 42  ? 39.925  21.887  -6.744  1.00 30.95 ? 42   ALA B O   1 ? 
ATOM   2664 C CB  . ALA B 1 42  ? 42.084  19.584  -6.880  1.00 34.16 ? 42   ALA B CB  1 ? 
ATOM   2665 N N   . ASP B 1 43  ? 40.979  22.153  -8.729  1.00 28.50 ? 43   ASP B N   1 ? 
ATOM   2666 C CA  . ASP B 1 43  ? 40.876  23.639  -8.747  1.00 26.49 ? 43   ASP B CA  1 ? 
ATOM   2667 C C   . ASP B 1 43  ? 39.514  24.080  -9.313  1.00 25.55 ? 43   ASP B C   1 ? 
ATOM   2668 O O   . ASP B 1 43  ? 39.255  25.303  -9.353  1.00 24.43 ? 43   ASP B O   1 ? 
ATOM   2669 C CB  . ASP B 1 43  ? 42.061  24.282  -9.472  1.00 27.49 ? 43   ASP B CB  1 ? 
ATOM   2670 C CG  . ASP B 1 43  ? 42.156  23.962  -10.953 1.00 28.00 ? 43   ASP B CG  1 ? 
ATOM   2671 O OD1 . ASP B 1 43  ? 41.413  23.076  -11.414 1.00 29.15 ? 43   ASP B OD1 1 ? 
ATOM   2672 O OD2 . ASP B 1 43  ? 42.973  24.602  -11.633 1.00 30.40 ? 43   ASP B OD2 1 ? 
ATOM   2673 N N   . VAL B 1 44  ? 38.643  23.144  -9.692  1.00 24.09 ? 44   VAL B N   1 ? 
ATOM   2674 C CA  . VAL B 1 44  ? 37.301  23.507  -10.238 1.00 23.29 ? 44   VAL B CA  1 ? 
ATOM   2675 C C   . VAL B 1 44  ? 36.384  23.834  -9.067  1.00 22.88 ? 44   VAL B C   1 ? 
ATOM   2676 O O   . VAL B 1 44  ? 36.298  23.008  -8.131  1.00 23.84 ? 44   VAL B O   1 ? 
ATOM   2677 C CB  . VAL B 1 44  ? 36.708  22.403  -11.129 1.00 21.95 ? 44   VAL B CB  1 ? 
ATOM   2678 C CG1 . VAL B 1 44  ? 35.329  22.787  -11.657 1.00 22.80 ? 44   VAL B CG1 1 ? 
ATOM   2679 C CG2 . VAL B 1 44  ? 37.646  22.081  -12.263 1.00 23.62 ? 44   VAL B CG2 1 ? 
ATOM   2680 N N   . GLU B 1 45  ? 35.706  24.980  -9.131  1.00 20.24 ? 45   GLU B N   1 ? 
ATOM   2681 C CA  . GLU B 1 45  ? 34.646  25.358  -8.173  1.00 22.67 ? 45   GLU B CA  1 ? 
ATOM   2682 C C   . GLU B 1 45  ? 33.298  25.285  -8.885  1.00 20.58 ? 45   GLU B C   1 ? 
ATOM   2683 O O   . GLU B 1 45  ? 33.108  25.950  -9.911  1.00 19.70 ? 45   GLU B O   1 ? 
ATOM   2684 C CB  . GLU B 1 45  ? 34.906  26.747  -7.596  1.00 27.42 ? 45   GLU B CB  1 ? 
ATOM   2685 C CG  . GLU B 1 45  ? 36.322  26.874  -7.070  1.00 33.44 ? 45   GLU B CG  1 ? 
ATOM   2686 C CD  . GLU B 1 45  ? 36.542  27.982  -6.055  1.00 41.43 ? 45   GLU B CD  1 ? 
ATOM   2687 O OE1 . GLU B 1 45  ? 36.029  29.109  -6.274  1.00 43.60 ? 45   GLU B OE1 1 ? 
ATOM   2688 O OE2 . GLU B 1 45  ? 37.234  27.710  -5.039  1.00 47.17 ? 45   GLU B OE2 1 ? 
ATOM   2689 N N   A LEU B 1 46  ? 32.428  24.407  -8.398  0.50 19.86 ? 46   LEU B N   1 ? 
ATOM   2690 N N   B LEU B 1 46  ? 32.337  24.626  -8.246  0.50 19.56 ? 46   LEU B N   1 ? 
ATOM   2691 C CA  A LEU B 1 46  ? 31.038  24.207  -8.874  0.50 19.90 ? 46   LEU B CA  1 ? 
ATOM   2692 C CA  B LEU B 1 46  ? 30.932  24.532  -8.707  0.50 19.74 ? 46   LEU B CA  1 ? 
ATOM   2693 C C   A LEU B 1 46  ? 30.124  24.729  -7.776  0.50 18.91 ? 46   LEU B C   1 ? 
ATOM   2694 C C   B LEU B 1 46  ? 30.018  25.075  -7.605  0.50 20.04 ? 46   LEU B C   1 ? 
ATOM   2695 O O   A LEU B 1 46  ? 30.319  24.296  -6.627  0.50 19.70 ? 46   LEU B O   1 ? 
ATOM   2696 O O   B LEU B 1 46  ? 30.238  24.713  -6.440  0.50 21.30 ? 46   LEU B O   1 ? 
ATOM   2697 C CB  A LEU B 1 46  ? 30.796  22.710  -9.097  0.50 21.67 ? 46   LEU B CB  1 ? 
ATOM   2698 C CB  B LEU B 1 46  ? 30.649  23.067  -9.048  0.50 20.63 ? 46   LEU B CB  1 ? 
ATOM   2699 C CG  A LEU B 1 46  ? 30.556  22.242  -10.533 0.50 22.24 ? 46   LEU B CG  1 ? 
ATOM   2700 C CG  B LEU B 1 46  ? 29.370  22.807  -9.831  0.50 20.14 ? 46   LEU B CG  1 ? 
ATOM   2701 C CD1 A LEU B 1 46  ? 29.293  22.861  -11.093 0.50 23.27 ? 46   LEU B CD1 1 ? 
ATOM   2702 C CD1 B LEU B 1 46  ? 29.519  21.602  -10.754 0.50 19.96 ? 46   LEU B CD1 1 ? 
ATOM   2703 C CD2 A LEU B 1 46  ? 31.748  22.527  -11.420 0.50 21.83 ? 46   LEU B CD2 1 ? 
ATOM   2704 C CD2 B LEU B 1 46  ? 28.197  22.615  -8.885  0.50 20.71 ? 46   LEU B CD2 1 ? 
ATOM   2705 N N   A THR B 1 47  ? 29.185  25.618  -8.091  0.50 17.87 ? 47   THR B N   1 ? 
ATOM   2706 N N   B THR B 1 47  ? 29.079  25.967  -7.934  0.50 19.81 ? 47   THR B N   1 ? 
ATOM   2707 C CA  A THR B 1 47  ? 28.164  26.036  -7.102  0.50 18.53 ? 47   THR B CA  1 ? 
ATOM   2708 C CA  B THR B 1 47  ? 28.077  26.477  -6.962  0.50 20.82 ? 47   THR B CA  1 ? 
ATOM   2709 C C   A THR B 1 47  ? 26.791  26.163  -7.763  0.50 18.11 ? 47   THR B C   1 ? 
ATOM   2710 C C   B THR B 1 47  ? 26.693  26.446  -7.620  0.50 20.00 ? 47   THR B C   1 ? 
ATOM   2711 O O   A THR B 1 47  ? 26.659  26.735  -8.852  0.50 17.28 ? 47   THR B O   1 ? 
ATOM   2712 O O   B THR B 1 47  ? 26.465  27.206  -8.599  0.50 19.96 ? 47   THR B O   1 ? 
ATOM   2713 C CB  A THR B 1 47  ? 28.567  27.280  -6.307  0.50 18.89 ? 47   THR B CB  1 ? 
ATOM   2714 C CB  B THR B 1 47  ? 28.501  27.826  -6.360  0.50 22.32 ? 47   THR B CB  1 ? 
ATOM   2715 O OG1 A THR B 1 47  ? 27.650  27.326  -5.208  0.50 18.37 ? 47   THR B OG1 1 ? 
ATOM   2716 O OG1 B THR B 1 47  ? 27.551  28.847  -6.656  0.50 25.10 ? 47   THR B OG1 1 ? 
ATOM   2717 C CG2 A THR B 1 47  ? 28.529  28.543  -7.132  0.50 17.66 ? 47   THR B CG2 1 ? 
ATOM   2718 C CG2 B THR B 1 47  ? 29.876  28.256  -6.810  0.50 20.98 ? 47   THR B CG2 1 ? 
ATOM   2719 N N   . THR B 1 48  ? 25.793  25.607  -7.095  1.00 19.16 ? 48   THR B N   1 ? 
ATOM   2720 C CA  . THR B 1 48  ? 24.403  25.551  -7.580  1.00 21.20 ? 48   THR B CA  1 ? 
ATOM   2721 C C   . THR B 1 48  ? 23.807  26.949  -7.448  1.00 22.13 ? 48   THR B C   1 ? 
ATOM   2722 O O   . THR B 1 48  ? 24.089  27.682  -6.467  1.00 20.63 ? 48   THR B O   1 ? 
ATOM   2723 C CB  . THR B 1 48  ? 23.607  24.434  -6.898  1.00 25.15 ? 48   THR B CB  1 ? 
ATOM   2724 O OG1 . THR B 1 48  ? 23.632  24.703  -5.504  1.00 26.10 ? 48   THR B OG1 1 ? 
ATOM   2725 C CG2 . THR B 1 48  ? 24.168  23.062  -7.202  1.00 25.70 ? 48   THR B CG2 1 ? 
ATOM   2726 N N   . VAL B 1 49  ? 22.971  27.306  -8.404  1.00 21.17 ? 49   VAL B N   1 ? 
ATOM   2727 C CA  . VAL B 1 49  ? 22.282  28.622  -8.452  1.00 20.75 ? 49   VAL B CA  1 ? 
ATOM   2728 C C   . VAL B 1 49  ? 20.898  28.452  -9.080  1.00 20.54 ? 49   VAL B C   1 ? 
ATOM   2729 O O   . VAL B 1 49  ? 20.716  27.522  -9.874  1.00 19.91 ? 49   VAL B O   1 ? 
ATOM   2730 C CB  . VAL B 1 49  ? 23.157  29.637  -9.204  1.00 23.04 ? 49   VAL B CB  1 ? 
ATOM   2731 C CG1 . VAL B 1 49  ? 23.314  29.274  -10.662 1.00 23.82 ? 49   VAL B CG1 1 ? 
ATOM   2732 C CG2 . VAL B 1 49  ? 22.659  31.058  -9.066  1.00 27.03 ? 49   VAL B CG2 1 ? 
ATOM   2733 N N   . ASP B 1 50  ? 19.959  29.300  -8.691  1.00 20.33 ? 50   ASP B N   1 ? 
ATOM   2734 C CA  . ASP B 1 50  ? 18.634  29.420  -9.335  1.00 19.99 ? 50   ASP B CA  1 ? 
ATOM   2735 C C   . ASP B 1 50  ? 18.788  30.484  -10.421 1.00 20.65 ? 50   ASP B C   1 ? 
ATOM   2736 O O   . ASP B 1 50  ? 18.872  31.675  -10.074 1.00 21.33 ? 50   ASP B O   1 ? 
ATOM   2737 C CB  . ASP B 1 50  ? 17.547  29.791  -8.328  1.00 22.36 ? 50   ASP B CB  1 ? 
ATOM   2738 C CG  . ASP B 1 50  ? 16.182  30.003  -8.957  1.00 26.78 ? 50   ASP B CG  1 ? 
ATOM   2739 O OD1 . ASP B 1 50  ? 15.993  29.565  -10.104 1.00 27.63 ? 50   ASP B OD1 1 ? 
ATOM   2740 O OD2 . ASP B 1 50  ? 15.306  30.592  -8.288  1.00 29.92 ? 50   ASP B OD2 1 ? 
ATOM   2741 N N   . ALA B 1 51  ? 18.898  30.058  -11.684 1.00 19.81 ? 51   ALA B N   1 ? 
ATOM   2742 C CA  . ALA B 1 51  ? 19.063  30.978  -12.834 1.00 20.84 ? 51   ALA B CA  1 ? 
ATOM   2743 C C   . ALA B 1 51  ? 17.684  31.402  -13.328 1.00 22.44 ? 51   ALA B C   1 ? 
ATOM   2744 O O   . ALA B 1 51  ? 17.254  30.957  -14.417 1.00 21.44 ? 51   ALA B O   1 ? 
ATOM   2745 C CB  . ALA B 1 51  ? 19.913  30.337  -13.901 1.00 20.88 ? 51   ALA B CB  1 ? 
ATOM   2746 N N   . GLY B 1 52  ? 17.004  32.239  -12.530 1.00 23.46 ? 52   GLY B N   1 ? 
ATOM   2747 C CA  . GLY B 1 52  ? 15.707  32.836  -12.886 1.00 24.41 ? 52   GLY B CA  1 ? 
ATOM   2748 C C   . GLY B 1 52  ? 14.611  31.799  -13.000 1.00 24.69 ? 52   GLY B C   1 ? 
ATOM   2749 O O   . GLY B 1 52  ? 13.746  31.998  -13.844 1.00 27.28 ? 52   GLY B O   1 ? 
ATOM   2750 N N   . GLY B 1 53  ? 14.646  30.745  -12.176 1.00 23.61 ? 53   GLY B N   1 ? 
ATOM   2751 C CA  . GLY B 1 53  ? 13.625  29.681  -12.149 1.00 23.28 ? 53   GLY B CA  1 ? 
ATOM   2752 C C   . GLY B 1 53  ? 14.108  28.403  -12.819 1.00 24.11 ? 53   GLY B C   1 ? 
ATOM   2753 O O   . GLY B 1 53  ? 13.357  27.423  -12.802 1.00 27.97 ? 53   GLY B O   1 ? 
ATOM   2754 N N   . VAL B 1 54  ? 15.332  28.395  -13.351 1.00 20.23 ? 54   VAL B N   1 ? 
ATOM   2755 C CA  . VAL B 1 54  ? 15.961  27.183  -13.935 1.00 19.94 ? 54   VAL B CA  1 ? 
ATOM   2756 C C   . VAL B 1 54  ? 17.138  26.807  -13.048 1.00 17.58 ? 54   VAL B C   1 ? 
ATOM   2757 O O   . VAL B 1 54  ? 18.015  27.628  -12.842 1.00 15.84 ? 54   VAL B O   1 ? 
ATOM   2758 C CB  . VAL B 1 54  ? 16.426  27.424  -15.378 1.00 20.87 ? 54   VAL B CB  1 ? 
ATOM   2759 C CG1 . VAL B 1 54  ? 17.053  26.161  -15.959 1.00 22.16 ? 54   VAL B CG1 1 ? 
ATOM   2760 C CG2 . VAL B 1 54  ? 15.285  27.938  -16.245 1.00 22.56 ? 54   VAL B CG2 1 ? 
ATOM   2761 N N   . PRO B 1 55  ? 17.213  25.579  -12.501 1.00 18.54 ? 55   PRO B N   1 ? 
ATOM   2762 C CA  . PRO B 1 55  ? 18.369  25.203  -11.710 1.00 17.82 ? 55   PRO B CA  1 ? 
ATOM   2763 C C   . PRO B 1 55  ? 19.622  25.167  -12.582 1.00 17.82 ? 55   PRO B C   1 ? 
ATOM   2764 O O   . PRO B 1 55  ? 19.593  24.715  -13.710 1.00 17.33 ? 55   PRO B O   1 ? 
ATOM   2765 C CB  . PRO B 1 55  ? 18.066  23.808  -11.163 1.00 19.51 ? 55   PRO B CB  1 ? 
ATOM   2766 C CG  . PRO B 1 55  ? 16.884  23.303  -11.956 1.00 21.15 ? 55   PRO B CG  1 ? 
ATOM   2767 C CD  . PRO B 1 55  ? 16.234  24.486  -12.630 1.00 19.41 ? 55   PRO B CD  1 ? 
ATOM   2768 N N   . GLY B 1 56  ? 20.725  25.619  -12.028 1.00 16.31 ? 56   GLY B N   1 ? 
ATOM   2769 C CA  . GLY B 1 56  ? 21.989  25.588  -12.751 1.00 17.59 ? 56   GLY B CA  1 ? 
ATOM   2770 C C   . GLY B 1 56  ? 23.140  25.519  -11.805 1.00 15.78 ? 56   GLY B C   1 ? 
ATOM   2771 O O   . GLY B 1 56  ? 22.923  25.344  -10.582 1.00 17.93 ? 56   GLY B O   1 ? 
ATOM   2772 N N   . ALA B 1 57  ? 24.328  25.598  -12.356 1.00 15.74 ? 57   ALA B N   1 ? 
ATOM   2773 C CA  . ALA B 1 57  ? 25.576  25.647  -11.585 1.00 14.76 ? 57   ALA B CA  1 ? 
ATOM   2774 C C   . ALA B 1 57  ? 26.526  26.581  -12.302 1.00 14.96 ? 57   ALA B C   1 ? 
ATOM   2775 O O   . ALA B 1 57  ? 26.718  26.448  -13.512 1.00 15.75 ? 57   ALA B O   1 ? 
ATOM   2776 C CB  . ALA B 1 57  ? 26.215  24.294  -11.395 1.00 15.88 ? 57   ALA B CB  1 ? 
ATOM   2777 N N   . TRP B 1 58  ? 27.181  27.424  -11.521 1.00 14.49 ? 58   TRP B N   1 ? 
ATOM   2778 C CA  . TRP B 1 58  ? 28.402  28.127  -11.961 1.00 14.62 ? 58   TRP B CA  1 ? 
ATOM   2779 C C   . TRP B 1 58  ? 29.543  27.128  -11.963 1.00 15.68 ? 58   TRP B C   1 ? 
ATOM   2780 O O   . TRP B 1 58  ? 29.766  26.439  -10.942 1.00 17.16 ? 58   TRP B O   1 ? 
ATOM   2781 C CB  . TRP B 1 58  ? 28.720  29.301  -11.046 1.00 14.93 ? 58   TRP B CB  1 ? 
ATOM   2782 C CG  . TRP B 1 58  ? 27.760  30.426  -11.159 1.00 16.13 ? 58   TRP B CG  1 ? 
ATOM   2783 C CD1 . TRP B 1 58  ? 26.965  30.919  -10.167 1.00 17.52 ? 58   TRP B CD1 1 ? 
ATOM   2784 C CD2 . TRP B 1 58  ? 27.593  31.288  -12.292 1.00 16.79 ? 58   TRP B CD2 1 ? 
ATOM   2785 N NE1 . TRP B 1 58  ? 26.250  31.978  -10.638 1.00 18.03 ? 58   TRP B NE1 1 ? 
ATOM   2786 C CE2 . TRP B 1 58  ? 26.637  32.247  -11.922 1.00 17.07 ? 58   TRP B CE2 1 ? 
ATOM   2787 C CE3 . TRP B 1 58  ? 28.144  31.320  -13.579 1.00 17.07 ? 58   TRP B CE3 1 ? 
ATOM   2788 C CZ2 . TRP B 1 58  ? 26.219  33.242  -12.805 1.00 18.63 ? 58   TRP B CZ2 1 ? 
ATOM   2789 C CZ3 . TRP B 1 58  ? 27.741  32.312  -14.448 1.00 17.13 ? 58   TRP B CZ3 1 ? 
ATOM   2790 C CH2 . TRP B 1 58  ? 26.766  33.236  -14.070 1.00 16.82 ? 58   TRP B CH2 1 ? 
ATOM   2791 N N   . VAL B 1 59  ? 30.278  27.086  -13.062 1.00 14.43 ? 59   VAL B N   1 ? 
ATOM   2792 C CA  . VAL B 1 59  ? 31.507  26.275  -13.178 1.00 15.68 ? 59   VAL B CA  1 ? 
ATOM   2793 C C   . VAL B 1 59  ? 32.645  27.259  -13.410 1.00 15.70 ? 59   VAL B C   1 ? 
ATOM   2794 O O   . VAL B 1 59  ? 32.607  27.997  -14.443 1.00 15.16 ? 59   VAL B O   1 ? 
ATOM   2795 C CB  . VAL B 1 59  ? 31.403  25.227  -14.299 1.00 16.88 ? 59   VAL B CB  1 ? 
ATOM   2796 C CG1 . VAL B 1 59  ? 32.678  24.412  -14.393 1.00 17.32 ? 59   VAL B CG1 1 ? 
ATOM   2797 C CG2 . VAL B 1 59  ? 30.174  24.336  -14.144 1.00 17.49 ? 59   VAL B CG2 1 ? 
ATOM   2798 N N   . ARG B 1 60  ? 33.586  27.303  -12.468 1.00 16.33 ? 60   ARG B N   1 ? 
ATOM   2799 C CA  . ARG B 1 60  ? 34.669  28.309  -12.457 1.00 17.12 ? 60   ARG B CA  1 ? 
ATOM   2800 C C   . ARG B 1 60  ? 36.001  27.630  -12.180 1.00 18.17 ? 60   ARG B C   1 ? 
ATOM   2801 O O   . ARG B 1 60  ? 36.055  26.614  -11.485 1.00 18.55 ? 60   ARG B O   1 ? 
ATOM   2802 C CB  . ARG B 1 60  ? 34.335  29.372  -11.403 1.00 18.43 ? 60   ARG B CB  1 ? 
ATOM   2803 C CG  . ARG B 1 60  ? 33.140  30.241  -11.765 1.00 19.05 ? 60   ARG B CG  1 ? 
ATOM   2804 C CD  . ARG B 1 60  ? 32.459  30.862  -10.567 1.00 22.03 ? 60   ARG B CD  1 ? 
ATOM   2805 N NE  . ARG B 1 60  ? 33.363  31.715  -9.801  1.00 22.06 ? 60   ARG B NE  1 ? 
ATOM   2806 C CZ  . ARG B 1 60  ? 33.967  31.382  -8.663  1.00 23.63 ? 60   ARG B CZ  1 ? 
ATOM   2807 N NH1 . ARG B 1 60  ? 33.760  30.202  -8.098  1.00 23.30 ? 60   ARG B NH1 1 ? 
ATOM   2808 N NH2 . ARG B 1 60  ? 34.773  32.255  -8.079  1.00 25.57 ? 60   ARG B NH2 1 ? 
ATOM   2809 N N   . VAL B 1 61  ? 37.055  28.182  -12.747 1.00 16.84 ? 61   VAL B N   1 ? 
ATOM   2810 C CA  . VAL B 1 61  ? 38.456  27.749  -12.540 1.00 19.26 ? 61   VAL B CA  1 ? 
ATOM   2811 C C   . VAL B 1 61  ? 39.250  28.998  -12.200 1.00 18.94 ? 61   VAL B C   1 ? 
ATOM   2812 O O   . VAL B 1 61  ? 38.757  30.114  -12.329 1.00 18.70 ? 61   VAL B O   1 ? 
ATOM   2813 C CB  . VAL B 1 61  ? 39.001  26.985  -13.761 1.00 19.70 ? 61   VAL B CB  1 ? 
ATOM   2814 C CG1 . VAL B 1 61  ? 38.234  25.686  -13.964 1.00 20.73 ? 61   VAL B CG1 1 ? 
ATOM   2815 C CG2 . VAL B 1 61  ? 38.971  27.819  -15.030 1.00 19.72 ? 61   VAL B CG2 1 ? 
ATOM   2816 N N   . PRO B 1 62  ? 40.489  28.852  -11.688 1.00 22.24 ? 62   PRO B N   1 ? 
ATOM   2817 C CA  . PRO B 1 62  ? 41.296  30.025  -11.349 1.00 24.74 ? 62   PRO B CA  1 ? 
ATOM   2818 C C   . PRO B 1 62  ? 41.433  31.013  -12.524 1.00 24.85 ? 62   PRO B C   1 ? 
ATOM   2819 O O   . PRO B 1 62  ? 41.400  32.193  -12.270 1.00 28.04 ? 62   PRO B O   1 ? 
ATOM   2820 C CB  . PRO B 1 62  ? 42.632  29.395  -10.952 1.00 25.64 ? 62   PRO B CB  1 ? 
ATOM   2821 C CG  . PRO B 1 62  ? 42.252  28.017  -10.426 1.00 24.38 ? 62   PRO B CG  1 ? 
ATOM   2822 C CD  . PRO B 1 62  ? 41.150  27.578  -11.366 1.00 24.31 ? 62   PRO B CD  1 ? 
ATOM   2823 N N   . GLU B 1 63  ? 41.492  30.496  -13.759 1.00 26.59 ? 63   GLU B N   1 ? 
ATOM   2824 C CA  . GLU B 1 63  ? 41.595  31.244  -15.041 1.00 26.73 ? 63   GLU B CA  1 ? 
ATOM   2825 C C   . GLU B 1 63  ? 40.306  32.025  -15.368 1.00 24.65 ? 63   GLU B C   1 ? 
ATOM   2826 O O   . GLU B 1 63  ? 40.351  32.853  -16.269 1.00 23.97 ? 63   GLU B O   1 ? 
ATOM   2827 C CB  . GLU B 1 63  ? 41.812  30.282  -16.219 1.00 28.94 ? 63   GLU B CB  1 ? 
ATOM   2828 C CG  . GLU B 1 63  ? 43.130  29.527  -16.243 1.00 31.66 ? 63   GLU B CG  1 ? 
ATOM   2829 C CD  . GLU B 1 63  ? 43.223  28.294  -15.353 1.00 34.81 ? 63   GLU B CD  1 ? 
ATOM   2830 O OE1 . GLU B 1 63  ? 42.378  28.147  -14.455 1.00 31.60 ? 63   GLU B OE1 1 ? 
ATOM   2831 O OE2 . GLU B 1 63  ? 44.165  27.502  -15.546 1.00 40.32 ? 63   GLU B OE2 1 ? 
ATOM   2832 N N   . SER B 1 64  ? 39.172  31.721  -14.738 1.00 21.18 ? 64   SER B N   1 ? 
ATOM   2833 C CA  . SER B 1 64  ? 37.864  32.332  -15.089 1.00 19.98 ? 64   SER B CA  1 ? 
ATOM   2834 C C   . SER B 1 64  ? 37.877  33.844  -14.879 1.00 22.01 ? 64   SER B C   1 ? 
ATOM   2835 O O   . SER B 1 64  ? 38.128  34.288  -13.747 1.00 25.31 ? 64   SER B O   1 ? 
ATOM   2836 C CB  . SER B 1 64  ? 36.728  31.734  -14.318 1.00 19.73 ? 64   SER B CB  1 ? 
ATOM   2837 O OG  . SER B 1 64  ? 36.556  30.390  -14.692 1.00 18.78 ? 64   SER B OG  1 ? 
ATOM   2838 N N   . ASP B 1 65  ? 37.559  34.597  -15.927 1.00 18.89 ? 65   ASP B N   1 ? 
ATOM   2839 C CA  . ASP B 1 65  ? 37.228  36.034  -15.838 1.00 19.65 ? 65   ASP B CA  1 ? 
ATOM   2840 C C   . ASP B 1 65  ? 35.717  36.158  -15.782 1.00 20.17 ? 65   ASP B C   1 ? 
ATOM   2841 O O   . ASP B 1 65  ? 35.033  35.882  -16.764 1.00 19.64 ? 65   ASP B O   1 ? 
ATOM   2842 C CB  . ASP B 1 65  ? 37.838  36.798  -17.011 1.00 20.33 ? 65   ASP B CB  1 ? 
ATOM   2843 C CG  . ASP B 1 65  ? 37.611  38.292  -16.981 1.00 24.18 ? 65   ASP B CG  1 ? 
ATOM   2844 O OD1 . ASP B 1 65  ? 36.733  38.749  -16.225 1.00 21.79 ? 65   ASP B OD1 1 ? 
ATOM   2845 O OD2 . ASP B 1 65  ? 38.279  38.974  -17.789 1.00 29.13 ? 65   ASP B OD2 1 ? 
ATOM   2846 N N   . PRO B 1 66  ? 35.126  36.578  -14.656 1.00 19.13 ? 66   PRO B N   1 ? 
ATOM   2847 C CA  . PRO B 1 66  ? 33.674  36.645  -14.534 1.00 19.14 ? 66   PRO B CA  1 ? 
ATOM   2848 C C   . PRO B 1 66  ? 33.000  37.703  -15.414 1.00 19.19 ? 66   PRO B C   1 ? 
ATOM   2849 O O   . PRO B 1 66  ? 31.786  37.661  -15.538 1.00 20.77 ? 66   PRO B O   1 ? 
ATOM   2850 C CB  . PRO B 1 66  ? 33.398  36.991  -13.064 1.00 21.92 ? 66   PRO B CB  1 ? 
ATOM   2851 C CG  . PRO B 1 66  ? 34.728  36.905  -12.379 1.00 22.09 ? 66   PRO B CG  1 ? 
ATOM   2852 C CD  . PRO B 1 66  ? 35.809  37.011  -13.432 1.00 21.21 ? 66   PRO B CD  1 ? 
ATOM   2853 N N   . ASP B 1 67  ? 33.771  38.562  -16.077 1.00 19.46 ? 67   ASP B N   1 ? 
ATOM   2854 C CA  . ASP B 1 67  ? 33.188  39.492  -17.078 1.00 21.30 ? 67   ASP B CA  1 ? 
ATOM   2855 C C   . ASP B 1 67  ? 32.684  38.714  -18.301 1.00 20.14 ? 67   ASP B C   1 ? 
ATOM   2856 O O   . ASP B 1 67  ? 31.858  39.278  -19.058 1.00 22.65 ? 67   ASP B O   1 ? 
ATOM   2857 C CB  . ASP B 1 67  ? 34.195  40.581  -17.431 1.00 23.16 ? 67   ASP B CB  1 ? 
ATOM   2858 C CG  . ASP B 1 67  ? 34.242  41.625  -16.325 1.00 26.94 ? 67   ASP B CG  1 ? 
ATOM   2859 O OD1 . ASP B 1 67  ? 33.146  42.125  -15.966 1.00 32.35 ? 67   ASP B OD1 1 ? 
ATOM   2860 O OD2 . ASP B 1 67  ? 35.345  41.879  -15.807 1.00 34.98 ? 67   ASP B OD2 1 ? 
ATOM   2861 N N   . ARG B 1 68  ? 33.187  37.503  -18.520 1.00 18.17 ? 68   ARG B N   1 ? 
ATOM   2862 C CA  . ARG B 1 68  ? 32.778  36.702  -19.702 1.00 17.71 ? 68   ARG B CA  1 ? 
ATOM   2863 C C   . ARG B 1 68  ? 32.000  35.495  -19.206 1.00 15.26 ? 68   ARG B C   1 ? 
ATOM   2864 O O   . ARG B 1 68  ? 32.424  34.846  -18.222 1.00 16.36 ? 68   ARG B O   1 ? 
ATOM   2865 C CB  . ARG B 1 68  ? 33.984  36.239  -20.509 1.00 19.84 ? 68   ARG B CB  1 ? 
ATOM   2866 C CG  . ARG B 1 68  ? 34.780  37.391  -21.099 1.00 23.46 ? 68   ARG B CG  1 ? 
ATOM   2867 C CD  . ARG B 1 68  ? 36.027  37.535  -20.269 1.00 26.79 ? 68   ARG B CD  1 ? 
ATOM   2868 N NE  . ARG B 1 68  ? 36.996  36.561  -20.750 1.00 28.80 ? 68   ARG B NE  1 ? 
ATOM   2869 C CZ  . ARG B 1 68  ? 37.791  36.744  -21.795 1.00 29.69 ? 68   ARG B CZ  1 ? 
ATOM   2870 N NH1 . ARG B 1 68  ? 38.628  35.785  -22.166 1.00 29.21 ? 68   ARG B NH1 1 ? 
ATOM   2871 N NH2 . ARG B 1 68  ? 37.730  37.875  -22.482 1.00 31.41 ? 68   ARG B NH2 1 ? 
ATOM   2872 N N   A VAL B 1 69  ? 30.889  35.174  -19.861 0.50 14.35 ? 69   VAL B N   1 ? 
ATOM   2873 N N   B VAL B 1 69  ? 30.938  35.159  -19.929 0.50 15.41 ? 69   VAL B N   1 ? 
ATOM   2874 C CA  A VAL B 1 69  ? 30.069  34.012  -19.412 0.50 13.35 ? 69   VAL B CA  1 ? 
ATOM   2875 C CA  B VAL B 1 69  ? 29.994  34.080  -19.534 0.50 15.19 ? 69   VAL B CA  1 ? 
ATOM   2876 C C   A VAL B 1 69  ? 29.580  33.231  -20.623 0.50 13.19 ? 69   VAL B C   1 ? 
ATOM   2877 C C   B VAL B 1 69  ? 29.733  33.214  -20.757 0.50 14.26 ? 69   VAL B C   1 ? 
ATOM   2878 O O   A VAL B 1 69  ? 29.020  33.864  -21.538 0.50 11.69 ? 69   VAL B O   1 ? 
ATOM   2879 O O   B VAL B 1 69  ? 29.565  33.750  -21.855 0.50 13.46 ? 69   VAL B O   1 ? 
ATOM   2880 C CB  A VAL B 1 69  ? 28.895  34.412  -18.502 0.50 13.22 ? 69   VAL B CB  1 ? 
ATOM   2881 C CB  B VAL B 1 69  ? 28.688  34.649  -18.956 0.50 16.24 ? 69   VAL B CB  1 ? 
ATOM   2882 C CG1 A VAL B 1 69  ? 27.907  35.347  -19.183 0.50 12.79 ? 69   VAL B CG1 1 ? 
ATOM   2883 C CG1 B VAL B 1 69  ? 27.678  33.565  -18.600 0.50 17.04 ? 69   VAL B CG1 1 ? 
ATOM   2884 C CG2 A VAL B 1 69  ? 28.185  33.171  -17.978 0.50 12.90 ? 69   VAL B CG2 1 ? 
ATOM   2885 C CG2 B VAL B 1 69  ? 28.971  35.490  -17.736 0.50 16.75 ? 69   VAL B CG2 1 ? 
ATOM   2886 N N   . VAL B 1 70  ? 29.741  31.905  -20.547 1.00 12.78 ? 70   VAL B N   1 ? 
ATOM   2887 C CA  . VAL B 1 70  ? 29.125  30.954  -21.499 1.00 12.98 ? 70   VAL B CA  1 ? 
ATOM   2888 C C   . VAL B 1 70  ? 27.915  30.325  -20.812 1.00 13.32 ? 70   VAL B C   1 ? 
ATOM   2889 O O   . VAL B 1 70  ? 28.085  29.760  -19.725 1.00 12.70 ? 70   VAL B O   1 ? 
ATOM   2890 C CB  . VAL B 1 70  ? 30.117  29.893  -21.952 1.00 14.02 ? 70   VAL B CB  1 ? 
ATOM   2891 C CG1 . VAL B 1 70  ? 29.402  28.838  -22.791 1.00 14.32 ? 70   VAL B CG1 1 ? 
ATOM   2892 C CG2 . VAL B 1 70  ? 31.268  30.507  -22.726 1.00 14.65 ? 70   VAL B CG2 1 ? 
ATOM   2893 N N   . LEU B 1 71  ? 26.739  30.455  -21.416 1.00 11.91 ? 71   LEU B N   1 ? 
ATOM   2894 C CA  . LEU B 1 71  ? 25.560  29.628  -21.061 1.00 11.90 ? 71   LEU B CA  1 ? 
ATOM   2895 C C   . LEU B 1 71  ? 25.726  28.299  -21.782 1.00 11.41 ? 71   LEU B C   1 ? 
ATOM   2896 O O   . LEU B 1 71  ? 25.745  28.288  -23.029 1.00 11.61 ? 71   LEU B O   1 ? 
ATOM   2897 C CB  . LEU B 1 71  ? 24.269  30.315  -21.483 1.00 12.16 ? 71   LEU B CB  1 ? 
ATOM   2898 C CG  . LEU B 1 71  ? 22.999  29.471  -21.358 1.00 13.26 ? 71   LEU B CG  1 ? 
ATOM   2899 C CD1 . LEU B 1 71  ? 22.744  29.047  -19.918 1.00 13.89 ? 71   LEU B CD1 1 ? 
ATOM   2900 C CD2 . LEU B 1 71  ? 21.819  30.228  -21.898 1.00 14.31 ? 71   LEU B CD2 1 ? 
ATOM   2901 N N   . TYR B 1 72  ? 25.905  27.218  -21.029 1.00 10.95 ? 72   TYR B N   1 ? 
ATOM   2902 C CA  . TYR B 1 72  ? 26.238  25.894  -21.589 1.00 11.66 ? 72   TYR B CA  1 ? 
ATOM   2903 C C   . TYR B 1 72  ? 24.979  25.020  -21.515 1.00 11.51 ? 72   TYR B C   1 ? 
ATOM   2904 O O   . TYR B 1 72  ? 24.403  24.838  -20.419 1.00 11.62 ? 72   TYR B O   1 ? 
ATOM   2905 C CB  . TYR B 1 72  ? 27.455  25.225  -20.934 1.00 12.12 ? 72   TYR B CB  1 ? 
ATOM   2906 C CG  . TYR B 1 72  ? 27.903  24.079  -21.794 1.00 12.46 ? 72   TYR B CG  1 ? 
ATOM   2907 C CD1 . TYR B 1 72  ? 27.260  22.848  -21.745 1.00 13.51 ? 72   TYR B CD1 1 ? 
ATOM   2908 C CD2 . TYR B 1 72  ? 28.809  24.291  -22.819 1.00 13.41 ? 72   TYR B CD2 1 ? 
ATOM   2909 C CE1 . TYR B 1 72  ? 27.596  21.836  -22.631 1.00 13.87 ? 72   TYR B CE1 1 ? 
ATOM   2910 C CE2 . TYR B 1 72  ? 29.157  23.288  -23.711 1.00 15.20 ? 72   TYR B CE2 1 ? 
ATOM   2911 C CZ  . TYR B 1 72  ? 28.542  22.055  -23.623 1.00 15.47 ? 72   TYR B CZ  1 ? 
ATOM   2912 O OH  . TYR B 1 72  ? 28.879  21.094  -24.547 1.00 17.23 ? 72   TYR B OH  1 ? 
ATOM   2913 N N   . LEU B 1 73  ? 24.611  24.457  -22.667 1.00 11.51 ? 73   LEU B N   1 ? 
ATOM   2914 C CA  . LEU B 1 73  ? 23.409  23.617  -22.876 1.00 11.63 ? 73   LEU B CA  1 ? 
ATOM   2915 C C   . LEU B 1 73  ? 23.855  22.195  -23.191 1.00 11.19 ? 73   LEU B C   1 ? 
ATOM   2916 O O   . LEU B 1 73  ? 24.355  21.943  -24.282 1.00 11.85 ? 73   LEU B O   1 ? 
ATOM   2917 C CB  . LEU B 1 73  ? 22.572  24.227  -24.000 1.00 12.04 ? 73   LEU B CB  1 ? 
ATOM   2918 C CG  . LEU B 1 73  ? 22.192  25.685  -23.769 1.00 12.75 ? 73   LEU B CG  1 ? 
ATOM   2919 C CD1 . LEU B 1 73  ? 21.367  26.229  -24.925 1.00 13.27 ? 73   LEU B CD1 1 ? 
ATOM   2920 C CD2 . LEU B 1 73  ? 21.451  25.860  -22.426 1.00 13.14 ? 73   LEU B CD2 1 ? 
ATOM   2921 N N   . HIS B 1 74  ? 23.712  21.288  -22.223 1.00 11.14 ? 74   HIS B N   1 ? 
ATOM   2922 C CA  . HIS B 1 74  ? 24.267  19.926  -22.348 1.00 11.31 ? 74   HIS B CA  1 ? 
ATOM   2923 C C   . HIS B 1 74  ? 23.482  19.122  -23.378 1.00 11.26 ? 74   HIS B C   1 ? 
ATOM   2924 O O   . HIS B 1 74  ? 22.281  19.405  -23.602 1.00 11.83 ? 74   HIS B O   1 ? 
ATOM   2925 C CB  . HIS B 1 74  ? 24.295  19.243  -20.981 1.00 11.88 ? 74   HIS B CB  1 ? 
ATOM   2926 C CG  . HIS B 1 74  ? 22.948  18.879  -20.449 1.00 11.93 ? 74   HIS B CG  1 ? 
ATOM   2927 N ND1 . HIS B 1 74  ? 22.248  17.747  -20.887 1.00 12.03 ? 74   HIS B ND1 1 ? 
ATOM   2928 C CD2 . HIS B 1 74  ? 22.192  19.427  -19.475 1.00 12.55 ? 74   HIS B CD2 1 ? 
ATOM   2929 C CE1 . HIS B 1 74  ? 21.104  17.673  -20.224 1.00 12.16 ? 74   HIS B CE1 1 ? 
ATOM   2930 N NE2 . HIS B 1 74  ? 21.050  18.657  -19.339 1.00 12.47 ? 74   HIS B NE2 1 ? 
ATOM   2931 N N   . GLY B 1 75  ? 24.143  18.099  -23.912 1.00 11.83 ? 75   GLY B N   1 ? 
ATOM   2932 C CA  . GLY B 1 75  ? 23.525  17.119  -24.805 1.00 12.31 ? 75   GLY B CA  1 ? 
ATOM   2933 C C   . GLY B 1 75  ? 22.892  15.967  -24.057 1.00 12.99 ? 75   GLY B C   1 ? 
ATOM   2934 O O   . GLY B 1 75  ? 22.877  15.957  -22.811 1.00 13.70 ? 75   GLY B O   1 ? 
ATOM   2935 N N   . GLY B 1 76  ? 22.374  15.013  -24.824 1.00 13.14 ? 76   GLY B N   1 ? 
ATOM   2936 C CA  . GLY B 1 76  ? 21.613  13.884  -24.261 1.00 12.90 ? 76   GLY B CA  1 ? 
ATOM   2937 C C   . GLY B 1 76  ? 20.257  13.708  -24.894 1.00 12.57 ? 76   GLY B C   1 ? 
ATOM   2938 O O   . GLY B 1 76  ? 19.367  13.159  -24.230 1.00 13.01 ? 76   GLY B O   1 ? 
ATOM   2939 N N   . GLY B 1 77  ? 20.080  14.123  -26.147 1.00 12.31 ? 77   GLY B N   1 ? 
ATOM   2940 C CA  . GLY B 1 77  ? 18.848  13.814  -26.898 1.00 11.88 ? 77   GLY B CA  1 ? 
ATOM   2941 C C   . GLY B 1 77  ? 17.609  14.491  -26.358 1.00 12.38 ? 77   GLY B C   1 ? 
ATOM   2942 O O   . GLY B 1 77  ? 16.514  14.079  -26.768 1.00 12.86 ? 77   GLY B O   1 ? 
ATOM   2943 N N   . TYR B 1 78  ? 17.752  15.517  -25.502 1.00 11.87 ? 78   TYR B N   1 ? 
ATOM   2944 C CA  . TYR B 1 78  ? 16.666  16.224  -24.792 1.00 11.93 ? 78   TYR B CA  1 ? 
ATOM   2945 C C   . TYR B 1 78  ? 16.040  15.303  -23.735 1.00 12.93 ? 78   TYR B C   1 ? 
ATOM   2946 O O   . TYR B 1 78  ? 14.987  15.686  -23.165 1.00 13.16 ? 78   TYR B O   1 ? 
ATOM   2947 C CB  . TYR B 1 78  ? 15.610  16.703  -25.781 1.00 12.42 ? 78   TYR B CB  1 ? 
ATOM   2948 C CG  . TYR B 1 78  ? 16.091  17.763  -26.745 1.00 12.82 ? 78   TYR B CG  1 ? 
ATOM   2949 C CD1 . TYR B 1 78  ? 16.299  19.058  -26.310 1.00 13.08 ? 78   TYR B CD1 1 ? 
ATOM   2950 C CD2 . TYR B 1 78  ? 16.301  17.484  -28.083 1.00 12.37 ? 78   TYR B CD2 1 ? 
ATOM   2951 C CE1 . TYR B 1 78  ? 16.722  20.053  -27.177 1.00 13.28 ? 78   TYR B CE1 1 ? 
ATOM   2952 C CE2 . TYR B 1 78  ? 16.702  18.473  -28.972 1.00 12.58 ? 78   TYR B CE2 1 ? 
ATOM   2953 C CZ  . TYR B 1 78  ? 16.925  19.765  -28.507 1.00 12.76 ? 78   TYR B CZ  1 ? 
ATOM   2954 O OH  . TYR B 1 78  ? 17.281  20.779  -29.368 1.00 14.15 ? 78   TYR B OH  1 ? 
ATOM   2955 N N   . VAL B 1 79  ? 16.674  14.155  -23.473 1.00 12.51 ? 79   VAL B N   1 ? 
ATOM   2956 C CA  . VAL B 1 79  ? 16.118  13.114  -22.559 1.00 13.33 ? 79   VAL B CA  1 ? 
ATOM   2957 C C   . VAL B 1 79  ? 17.085  12.807  -21.420 1.00 12.81 ? 79   VAL B C   1 ? 
ATOM   2958 O O   . VAL B 1 79  ? 16.590  12.492  -20.337 1.00 14.06 ? 79   VAL B O   1 ? 
ATOM   2959 C CB  . VAL B 1 79  ? 15.751  11.852  -23.355 1.00 14.33 ? 79   VAL B CB  1 ? 
ATOM   2960 C CG1 . VAL B 1 79  ? 15.343  10.700  -22.450 1.00 16.03 ? 79   VAL B CG1 1 ? 
ATOM   2961 C CG2 . VAL B 1 79  ? 14.626  12.147  -24.340 1.00 14.97 ? 79   VAL B CG2 1 ? 
ATOM   2962 N N   . ILE B 1 80  ? 18.401  12.857  -21.627 1.00 12.78 ? 80   ILE B N   1 ? 
ATOM   2963 C CA  . ILE B 1 80  ? 19.396  12.478  -20.588 1.00 12.76 ? 80   ILE B CA  1 ? 
ATOM   2964 C C   . ILE B 1 80  ? 20.402  13.628  -20.437 1.00 12.69 ? 80   ILE B C   1 ? 
ATOM   2965 O O   . ILE B 1 80  ? 20.276  14.668  -21.131 1.00 12.46 ? 80   ILE B O   1 ? 
ATOM   2966 C CB  . ILE B 1 80  ? 20.066  11.117  -20.900 1.00 12.62 ? 80   ILE B CB  1 ? 
ATOM   2967 C CG1 . ILE B 1 80  ? 21.096  11.207  -22.029 1.00 13.58 ? 80   ILE B CG1 1 ? 
ATOM   2968 C CG2 . ILE B 1 80  ? 18.994  10.086  -21.240 1.00 13.41 ? 80   ILE B CG2 1 ? 
ATOM   2969 C CD1 . ILE B 1 80  ? 21.766  9.917   -22.400 1.00 14.59 ? 80   ILE B CD1 1 ? 
ATOM   2970 N N   . GLY B 1 81  ? 21.368  13.429  -19.554 1.00 12.95 ? 81   GLY B N   1 ? 
ATOM   2971 C CA  . GLY B 1 81  ? 22.376  14.439  -19.248 1.00 14.24 ? 81   GLY B CA  1 ? 
ATOM   2972 C C   . GLY B 1 81  ? 22.000  15.258  -18.047 1.00 15.30 ? 81   GLY B C   1 ? 
ATOM   2973 O O   . GLY B 1 81  ? 20.815  15.317  -17.658 1.00 15.48 ? 81   GLY B O   1 ? 
ATOM   2974 N N   . SER B 1 82  ? 23.000  15.920  -17.467 1.00 15.03 ? 82   SER B N   1 ? 
ATOM   2975 C CA  . SER B 1 82  ? 22.814  16.677  -16.214 1.00 15.74 ? 82   SER B CA  1 ? 
ATOM   2976 C C   . SER B 1 82  ? 23.999  17.609  -16.012 1.00 15.48 ? 82   SER B C   1 ? 
ATOM   2977 O O   . SER B 1 82  ? 24.990  17.522  -16.763 1.00 16.53 ? 82   SER B O   1 ? 
ATOM   2978 C CB  . SER B 1 82  ? 22.668  15.743  -15.051 1.00 16.12 ? 82   SER B CB  1 ? 
ATOM   2979 O OG  . SER B 1 82  ? 23.893  15.103  -14.789 1.00 17.69 ? 82   SER B OG  1 ? 
ATOM   2980 N N   . ILE B 1 83  ? 23.943  18.392  -14.942 1.00 16.99 ? 83   ILE B N   1 ? 
ATOM   2981 C CA  . ILE B 1 83  ? 25.141  19.139  -14.467 1.00 17.07 ? 83   ILE B CA  1 ? 
ATOM   2982 C C   . ILE B 1 83  ? 26.280  18.152  -14.218 1.00 16.05 ? 83   ILE B C   1 ? 
ATOM   2983 O O   . ILE B 1 83  ? 27.408  18.475  -14.594 1.00 15.80 ? 83   ILE B O   1 ? 
ATOM   2984 C CB  . ILE B 1 83  ? 24.784  19.981  -13.226 1.00 18.29 ? 83   ILE B CB  1 ? 
ATOM   2985 C CG1 . ILE B 1 83  ? 23.838  21.119  -13.614 1.00 19.78 ? 83   ILE B CG1 1 ? 
ATOM   2986 C CG2 . ILE B 1 83  ? 26.044  20.478  -12.541 1.00 19.05 ? 83   ILE B CG2 1 ? 
ATOM   2987 C CD1 . ILE B 1 83  ? 23.110  21.760  -12.455 1.00 20.67 ? 83   ILE B CD1 1 ? 
ATOM   2988 N N   . ARG B 1 84  ? 26.025  16.969  -13.640 1.00 17.15 ? 84   ARG B N   1 ? 
ATOM   2989 C CA  . ARG B 1 84  ? 27.102  16.015  -13.320 1.00 19.27 ? 84   ARG B CA  1 ? 
ATOM   2990 C C   . ARG B 1 84  ? 27.731  15.470  -14.610 1.00 17.71 ? 84   ARG B C   1 ? 
ATOM   2991 O O   . ARG B 1 84  ? 28.969  15.284  -14.605 1.00 17.79 ? 84   ARG B O   1 ? 
ATOM   2992 C CB  . ARG B 1 84  ? 26.621  14.825  -12.481 1.00 23.69 ? 84   ARG B CB  1 ? 
ATOM   2993 C CG  . ARG B 1 84  ? 26.640  15.041  -10.977 1.00 32.74 ? 84   ARG B CG  1 ? 
ATOM   2994 C CD  . ARG B 1 84  ? 26.397  13.691  -10.320 1.00 38.71 ? 84   ARG B CD  1 ? 
ATOM   2995 N NE  . ARG B 1 84  ? 25.552  13.755  -9.134  1.00 47.75 ? 84   ARG B NE  1 ? 
ATOM   2996 C CZ  . ARG B 1 84  ? 25.114  12.692  -8.457  1.00 53.32 ? 84   ARG B CZ  1 ? 
ATOM   2997 N NH1 . ARG B 1 84  ? 25.437  11.467  -8.843  1.00 57.08 ? 84   ARG B NH1 1 ? 
ATOM   2998 N NH2 . ARG B 1 84  ? 24.352  12.859  -7.389  1.00 54.72 ? 84   ARG B NH2 1 ? 
ATOM   2999 N N   . THR B 1 85  ? 26.956  15.207  -15.679 1.00 14.98 ? 85   THR B N   1 ? 
ATOM   3000 C CA  . THR B 1 85  ? 27.544  14.585  -16.879 1.00 14.86 ? 85   THR B CA  1 ? 
ATOM   3001 C C   . THR B 1 85  ? 28.443  15.579  -17.609 1.00 14.58 ? 85   THR B C   1 ? 
ATOM   3002 O O   . THR B 1 85  ? 29.394  15.129  -18.229 1.00 14.16 ? 85   THR B O   1 ? 
ATOM   3003 C CB  . THR B 1 85  ? 26.490  13.986  -17.820 1.00 15.40 ? 85   THR B CB  1 ? 
ATOM   3004 O OG1 . THR B 1 85  ? 25.567  14.965  -18.284 1.00 14.17 ? 85   THR B OG1 1 ? 
ATOM   3005 C CG2 . THR B 1 85  ? 25.746  12.855  -17.139 1.00 16.15 ? 85   THR B CG2 1 ? 
ATOM   3006 N N   . HIS B 1 86  ? 28.127  16.870  -17.559 1.00 14.26 ? 86   HIS B N   1 ? 
ATOM   3007 C CA  . HIS B 1 86  ? 28.791  17.877  -18.425 1.00 14.10 ? 86   HIS B CA  1 ? 
ATOM   3008 C C   . HIS B 1 86  ? 29.666  18.864  -17.646 1.00 15.55 ? 86   HIS B C   1 ? 
ATOM   3009 O O   . HIS B 1 86  ? 30.267  19.733  -18.285 1.00 15.52 ? 86   HIS B O   1 ? 
ATOM   3010 C CB  . HIS B 1 86  ? 27.741  18.587  -19.264 1.00 13.60 ? 86   HIS B CB  1 ? 
ATOM   3011 C CG  . HIS B 1 86  ? 27.305  17.767  -20.425 1.00 14.09 ? 86   HIS B CG  1 ? 
ATOM   3012 N ND1 . HIS B 1 86  ? 26.514  16.627  -20.286 1.00 15.01 ? 86   HIS B ND1 1 ? 
ATOM   3013 C CD2 . HIS B 1 86  ? 27.538  17.928  -21.740 1.00 13.69 ? 86   HIS B CD2 1 ? 
ATOM   3014 C CE1 . HIS B 1 86  ? 26.277  16.129  -21.490 1.00 14.71 ? 86   HIS B CE1 1 ? 
ATOM   3015 N NE2 . HIS B 1 86  ? 26.909  16.905  -22.401 1.00 15.29 ? 86   HIS B NE2 1 ? 
ATOM   3016 N N   . ARG B 1 87  ? 29.779  18.736  -16.326 1.00 15.07 ? 87   ARG B N   1 ? 
ATOM   3017 C CA  . ARG B 1 87  ? 30.599  19.707  -15.564 1.00 16.34 ? 87   ARG B CA  1 ? 
ATOM   3018 C C   . ARG B 1 87  ? 32.065  19.624  -15.982 1.00 15.44 ? 87   ARG B C   1 ? 
ATOM   3019 O O   . ARG B 1 87  ? 32.714  20.678  -15.956 1.00 14.99 ? 87   ARG B O   1 ? 
ATOM   3020 C CB  . ARG B 1 87  ? 30.409  19.548  -14.059 1.00 18.29 ? 87   ARG B CB  1 ? 
ATOM   3021 C CG  . ARG B 1 87  ? 30.802  18.183  -13.543 1.00 19.84 ? 87   ARG B CG  1 ? 
ATOM   3022 C CD  . ARG B 1 87  ? 30.498  18.054  -12.086 1.00 23.43 ? 87   ARG B CD  1 ? 
ATOM   3023 N NE  . ARG B 1 87  ? 31.030  16.793  -11.611 1.00 26.10 ? 87   ARG B NE  1 ? 
ATOM   3024 C CZ  . ARG B 1 87  ? 30.750  16.271  -10.419 1.00 33.85 ? 87   ARG B CZ  1 ? 
ATOM   3025 N NH1 . ARG B 1 87  ? 29.906  16.881  -9.603  1.00 34.48 ? 87   ARG B NH1 1 ? 
ATOM   3026 N NH2 . ARG B 1 87  ? 31.303  15.128  -10.060 1.00 37.99 ? 87   ARG B NH2 1 ? 
ATOM   3027 N N   . ASP B 1 88  ? 32.587  18.467  -16.394 1.00 14.68 ? 88   ASP B N   1 ? 
ATOM   3028 C CA  . ASP B 1 88  ? 34.006  18.391  -16.811 1.00 16.79 ? 88   ASP B CA  1 ? 
ATOM   3029 C C   . ASP B 1 88  ? 34.191  19.137  -18.139 1.00 16.31 ? 88   ASP B C   1 ? 
ATOM   3030 O O   . ASP B 1 88  ? 35.178  19.908  -18.275 1.00 18.42 ? 88   ASP B O   1 ? 
ATOM   3031 C CB  . ASP B 1 88  ? 34.508  16.957  -16.922 1.00 18.55 ? 88   ASP B CB  1 ? 
ATOM   3032 C CG  . ASP B 1 88  ? 35.965  16.921  -17.323 1.00 20.84 ? 88   ASP B CG  1 ? 
ATOM   3033 O OD1 . ASP B 1 88  ? 36.772  17.481  -16.544 1.00 22.87 ? 88   ASP B OD1 1 ? 
ATOM   3034 O OD2 . ASP B 1 88  ? 36.269  16.392  -18.429 1.00 24.06 ? 88   ASP B OD2 1 ? 
ATOM   3035 N N   . LEU B 1 89  ? 33.308  18.923  -19.117 1.00 16.07 ? 89   LEU B N   1 ? 
ATOM   3036 C CA  . LEU B 1 89  ? 33.437  19.666  -20.389 1.00 17.29 ? 89   LEU B CA  1 ? 
ATOM   3037 C C   . LEU B 1 89  ? 33.312  21.160  -20.083 1.00 16.00 ? 89   LEU B C   1 ? 
ATOM   3038 O O   . LEU B 1 89  ? 34.080  21.975  -20.665 1.00 16.05 ? 89   LEU B O   1 ? 
ATOM   3039 C CB  . LEU B 1 89  ? 32.358  19.164  -21.352 1.00 18.86 ? 89   LEU B CB  1 ? 
ATOM   3040 C CG  . LEU B 1 89  ? 32.343  19.803  -22.733 1.00 20.30 ? 89   LEU B CG  1 ? 
ATOM   3041 C CD1 . LEU B 1 89  ? 33.729  19.814  -23.366 1.00 21.39 ? 89   LEU B CD1 1 ? 
ATOM   3042 C CD2 . LEU B 1 89  ? 31.353  19.042  -23.609 1.00 20.47 ? 89   LEU B CD2 1 ? 
ATOM   3043 N N   . ALA B 1 90  ? 32.382  21.544  -19.209 1.00 15.83 ? 90   ALA B N   1 ? 
ATOM   3044 C CA  . ALA B 1 90  ? 32.154  22.958  -18.846 1.00 15.47 ? 90   ALA B CA  1 ? 
ATOM   3045 C C   . ALA B 1 90  ? 33.451  23.550  -18.279 1.00 15.09 ? 90   ALA B C   1 ? 
ATOM   3046 O O   . ALA B 1 90  ? 33.795  24.703  -18.636 1.00 15.22 ? 90   ALA B O   1 ? 
ATOM   3047 C CB  . ALA B 1 90  ? 31.004  23.094  -17.876 1.00 16.02 ? 90   ALA B CB  1 ? 
ATOM   3048 N N   . GLN B 1 91  ? 34.138  22.853  -17.368 1.00 15.27 ? 91   GLN B N   1 ? 
ATOM   3049 C CA  . GLN B 1 91  ? 35.319  23.460  -16.700 1.00 16.07 ? 91   GLN B CA  1 ? 
ATOM   3050 C C   . GLN B 1 91  ? 36.450  23.577  -17.720 1.00 15.58 ? 91   GLN B C   1 ? 
ATOM   3051 O O   . GLN B 1 91  ? 37.164  24.597  -17.696 1.00 16.01 ? 91   GLN B O   1 ? 
ATOM   3052 C CB  . GLN B 1 91  ? 35.722  22.707  -15.430 1.00 17.02 ? 91   GLN B CB  1 ? 
ATOM   3053 C CG  . GLN B 1 91  ? 36.290  21.314  -15.636 1.00 17.59 ? 91   GLN B CG  1 ? 
ATOM   3054 C CD  . GLN B 1 91  ? 37.775  21.253  -15.895 1.00 19.28 ? 91   GLN B CD  1 ? 
ATOM   3055 O OE1 . GLN B 1 91  ? 38.519  22.234  -15.766 1.00 21.21 ? 91   GLN B OE1 1 ? 
ATOM   3056 N NE2 . GLN B 1 91  ? 38.226  20.079  -16.298 1.00 20.92 ? 91   GLN B NE2 1 ? 
ATOM   3057 N N   . ARG B 1 92  ? 36.573  22.630  -18.650 1.00 14.93 ? 92   ARG B N   1 ? 
ATOM   3058 C CA  . ARG B 1 92  ? 37.621  22.717  -19.701 1.00 15.68 ? 92   ARG B CA  1 ? 
ATOM   3059 C C   . ARG B 1 92  ? 37.360  23.935  -20.590 1.00 14.87 ? 92   ARG B C   1 ? 
ATOM   3060 O O   . ARG B 1 92  ? 38.332  24.607  -20.973 1.00 15.58 ? 92   ARG B O   1 ? 
ATOM   3061 C CB  . ARG B 1 92  ? 37.669  21.432  -20.519 1.00 16.18 ? 92   ARG B CB  1 ? 
ATOM   3062 C CG  . ARG B 1 92  ? 38.251  20.260  -19.747 1.00 18.09 ? 92   ARG B CG  1 ? 
ATOM   3063 C CD  . ARG B 1 92  ? 38.192  18.964  -20.512 1.00 19.64 ? 92   ARG B CD  1 ? 
ATOM   3064 N NE  . ARG B 1 92  ? 38.481  17.879  -19.596 1.00 22.68 ? 92   ARG B NE  1 ? 
ATOM   3065 C CZ  . ARG B 1 92  ? 39.697  17.532  -19.195 1.00 23.68 ? 92   ARG B CZ  1 ? 
ATOM   3066 N NH1 . ARG B 1 92  ? 40.774  18.072  -19.742 1.00 25.02 ? 92   ARG B NH1 1 ? 
ATOM   3067 N NH2 . ARG B 1 92  ? 39.832  16.580  -18.289 1.00 27.61 ? 92   ARG B NH2 1 ? 
ATOM   3068 N N   . ILE B 1 93  ? 36.103  24.208  -20.936 1.00 15.28 ? 93   ILE B N   1 ? 
ATOM   3069 C CA  . ILE B 1 93  ? 35.759  25.413  -21.744 1.00 15.59 ? 93   ILE B CA  1 ? 
ATOM   3070 C C   . ILE B 1 93  ? 36.045  26.667  -20.908 1.00 16.46 ? 93   ILE B C   1 ? 
ATOM   3071 O O   . ILE B 1 93  ? 36.652  27.621  -21.457 1.00 16.38 ? 93   ILE B O   1 ? 
ATOM   3072 C CB  . ILE B 1 93  ? 34.313  25.341  -22.260 1.00 16.24 ? 93   ILE B CB  1 ? 
ATOM   3073 C CG1 . ILE B 1 93  ? 34.195  24.219  -23.289 1.00 16.37 ? 93   ILE B CG1 1 ? 
ATOM   3074 C CG2 . ILE B 1 93  ? 33.877  26.686  -22.823 1.00 16.94 ? 93   ILE B CG2 1 ? 
ATOM   3075 C CD1 . ILE B 1 93  ? 32.762  23.853  -23.625 1.00 16.99 ? 93   ILE B CD1 1 ? 
ATOM   3076 N N   . ALA B 1 94  ? 35.648  26.684  -19.634 1.00 15.52 ? 94   ALA B N   1 ? 
ATOM   3077 C CA  . ALA B 1 94  ? 35.900  27.831  -18.728 1.00 16.91 ? 94   ALA B CA  1 ? 
ATOM   3078 C C   . ALA B 1 94  ? 37.403  28.152  -18.754 1.00 16.75 ? 94   ALA B C   1 ? 
ATOM   3079 O O   . ALA B 1 94  ? 37.795  29.348  -18.819 1.00 17.46 ? 94   ALA B O   1 ? 
ATOM   3080 C CB  . ALA B 1 94  ? 35.449  27.501  -17.334 1.00 15.74 ? 94   ALA B CB  1 ? 
ATOM   3081 N N   . ARG B 1 95  ? 38.220  27.116  -18.681 1.00 17.37 ? 95   ARG B N   1 ? 
ATOM   3082 C CA  . ARG B 1 95  ? 39.694  27.243  -18.601 1.00 18.31 ? 95   ARG B CA  1 ? 
ATOM   3083 C C   . ARG B 1 95  ? 40.244  27.781  -19.932 1.00 18.84 ? 95   ARG B C   1 ? 
ATOM   3084 O O   . ARG B 1 95  ? 41.104  28.691  -19.923 1.00 19.93 ? 95   ARG B O   1 ? 
ATOM   3085 C CB  . ARG B 1 95  ? 40.274  25.873  -18.248 1.00 20.68 ? 95   ARG B CB  1 ? 
ATOM   3086 C CG  . ARG B 1 95  ? 41.644  25.920  -17.605 1.00 23.87 ? 95   ARG B CG  1 ? 
ATOM   3087 C CD  . ARG B 1 95  ? 42.122  24.507  -17.299 1.00 25.83 ? 95   ARG B CD  1 ? 
ATOM   3088 N NE  . ARG B 1 95  ? 41.306  23.779  -16.322 1.00 25.48 ? 95   ARG B NE  1 ? 
ATOM   3089 C CZ  . ARG B 1 95  ? 41.455  23.874  -14.995 1.00 26.36 ? 95   ARG B CZ  1 ? 
ATOM   3090 N NH1 . ARG B 1 95  ? 40.698  23.155  -14.186 1.00 25.88 ? 95   ARG B NH1 1 ? 
ATOM   3091 N NH2 . ARG B 1 95  ? 42.333  24.716  -14.470 1.00 25.81 ? 95   ARG B NH2 1 ? 
ATOM   3092 N N   . ALA B 1 96  ? 39.770  27.256  -21.055 1.00 17.05 ? 96   ALA B N   1 ? 
ATOM   3093 C CA  . ALA B 1 96  ? 40.316  27.595  -22.389 1.00 17.08 ? 96   ALA B CA  1 ? 
ATOM   3094 C C   . ALA B 1 96  ? 39.867  28.996  -22.792 1.00 17.14 ? 96   ALA B C   1 ? 
ATOM   3095 O O   . ALA B 1 96  ? 40.673  29.714  -23.405 1.00 18.40 ? 96   ALA B O   1 ? 
ATOM   3096 C CB  . ALA B 1 96  ? 39.897  26.553  -23.403 1.00 16.66 ? 96   ALA B CB  1 ? 
ATOM   3097 N N   . ALA B 1 97  ? 38.619  29.372  -22.504 1.00 15.97 ? 97   ALA B N   1 ? 
ATOM   3098 C CA  . ALA B 1 97  ? 38.043  30.680  -22.885 1.00 16.51 ? 97   ALA B CA  1 ? 
ATOM   3099 C C   . ALA B 1 97  ? 38.315  31.741  -21.806 1.00 16.90 ? 97   ALA B C   1 ? 
ATOM   3100 O O   . ALA B 1 97  ? 38.028  32.925  -22.044 1.00 17.53 ? 97   ALA B O   1 ? 
ATOM   3101 C CB  . ALA B 1 97  ? 36.559  30.525  -23.125 1.00 17.01 ? 97   ALA B CB  1 ? 
ATOM   3102 N N   . ARG B 1 98  ? 38.830  31.320  -20.644 1.00 17.73 ? 98   ARG B N   1 ? 
ATOM   3103 C CA  . ARG B 1 98  ? 39.065  32.189  -19.460 1.00 20.61 ? 98   ARG B CA  1 ? 
ATOM   3104 C C   . ARG B 1 98  ? 37.773  32.919  -19.095 1.00 17.69 ? 98   ARG B C   1 ? 
ATOM   3105 O O   . ARG B 1 98  ? 37.748  34.148  -19.010 1.00 19.05 ? 98   ARG B O   1 ? 
ATOM   3106 C CB  . ARG B 1 98  ? 40.242  33.131  -19.740 1.00 24.07 ? 98   ARG B CB  1 ? 
ATOM   3107 C CG  . ARG B 1 98  ? 41.552  32.398  -19.973 1.00 29.05 ? 98   ARG B CG  1 ? 
ATOM   3108 C CD  . ARG B 1 98  ? 42.736  33.351  -20.035 1.00 36.93 ? 98   ARG B CD  1 ? 
ATOM   3109 N NE  . ARG B 1 98  ? 43.671  32.849  -21.033 1.00 44.50 ? 98   ARG B NE  1 ? 
ATOM   3110 C CZ  . ARG B 1 98  ? 43.836  33.327  -22.270 1.00 48.44 ? 98   ARG B CZ  1 ? 
ATOM   3111 N NH1 . ARG B 1 98  ? 44.716  32.753  -23.075 1.00 51.02 ? 98   ARG B NH1 1 ? 
ATOM   3112 N NH2 . ARG B 1 98  ? 43.181  34.400  -22.685 1.00 51.60 ? 98   ARG B NH2 1 ? 
ATOM   3113 N N   . CYS B 1 99  ? 36.708  32.164  -18.857 1.00 16.22 ? 99   CYS B N   1 ? 
ATOM   3114 C CA  . CYS B 1 99  ? 35.355  32.679  -18.566 1.00 15.89 ? 99   CYS B CA  1 ? 
ATOM   3115 C C   . CYS B 1 99  ? 34.717  31.843  -17.458 1.00 14.03 ? 99   CYS B C   1 ? 
ATOM   3116 O O   . CYS B 1 99  ? 35.309  30.825  -17.052 1.00 15.67 ? 99   CYS B O   1 ? 
ATOM   3117 C CB  . CYS B 1 99  ? 34.470  32.634  -19.800 1.00 15.86 ? 99   CYS B CB  1 ? 
ATOM   3118 S SG  . CYS B 1 99  ? 34.055  30.958  -20.344 1.00 17.39 ? 99   CYS B SG  1 ? 
ATOM   3119 N N   . ARG B 1 100 ? 33.569  32.292  -16.974 1.00 14.56 ? 100  ARG B N   1 ? 
ATOM   3120 C CA  . ARG B 1 100 ? 32.738  31.425  -16.115 1.00 14.39 ? 100  ARG B CA  1 ? 
ATOM   3121 C C   . ARG B 1 100 ? 31.644  30.817  -16.987 1.00 14.69 ? 100  ARG B C   1 ? 
ATOM   3122 O O   . ARG B 1 100 ? 31.291  31.386  -18.021 1.00 14.65 ? 100  ARG B O   1 ? 
ATOM   3123 C CB  . ARG B 1 100 ? 32.232  32.130  -14.862 1.00 15.65 ? 100  ARG B CB  1 ? 
ATOM   3124 C CG  . ARG B 1 100 ? 31.267  33.277  -15.064 1.00 16.30 ? 100  ARG B CG  1 ? 
ATOM   3125 C CD  . ARG B 1 100 ? 31.101  33.901  -13.672 1.00 18.48 ? 100  ARG B CD  1 ? 
ATOM   3126 N NE  . ARG B 1 100 ? 29.985  34.809  -13.585 1.00 21.68 ? 100  ARG B NE  1 ? 
ATOM   3127 C CZ  . ARG B 1 100 ? 29.396  35.172  -12.434 1.00 21.64 ? 100  ARG B CZ  1 ? 
ATOM   3128 N NH1 . ARG B 1 100 ? 29.852  34.759  -11.268 1.00 24.13 ? 100  ARG B NH1 1 ? 
ATOM   3129 N NH2 . ARG B 1 100 ? 28.362  35.978  -12.453 1.00 24.90 ? 100  ARG B NH2 1 ? 
ATOM   3130 N N   . VAL B 1 101 ? 31.221  29.628  -16.603 1.00 13.59 ? 101  VAL B N   1 ? 
ATOM   3131 C CA  . VAL B 1 101 ? 30.197  28.872  -17.363 1.00 12.84 ? 101  VAL B CA  1 ? 
ATOM   3132 C C   . VAL B 1 101 ? 28.980  28.710  -16.464 1.00 13.22 ? 101  VAL B C   1 ? 
ATOM   3133 O O   . VAL B 1 101 ? 29.136  28.262  -15.304 1.00 14.18 ? 101  VAL B O   1 ? 
ATOM   3134 C CB  . VAL B 1 101 ? 30.754  27.529  -17.848 1.00 13.04 ? 101  VAL B CB  1 ? 
ATOM   3135 C CG1 . VAL B 1 101 ? 29.659  26.711  -18.519 1.00 14.51 ? 101  VAL B CG1 1 ? 
ATOM   3136 C CG2 . VAL B 1 101 ? 31.943  27.705  -18.776 1.00 14.60 ? 101  VAL B CG2 1 ? 
ATOM   3137 N N   . LEU B 1 102 ? 27.818  29.041  -16.987 1.00 12.98 ? 102  LEU B N   1 ? 
ATOM   3138 C CA  . LEU B 1 102 ? 26.531  28.708  -16.339 1.00 12.84 ? 102  LEU B CA  1 ? 
ATOM   3139 C C   . LEU B 1 102 ? 26.014  27.440  -17.008 1.00 13.49 ? 102  LEU B C   1 ? 
ATOM   3140 O O   . LEU B 1 102 ? 25.620  27.498  -18.180 1.00 12.90 ? 102  LEU B O   1 ? 
ATOM   3141 C CB  . LEU B 1 102 ? 25.525  29.855  -16.457 1.00 14.25 ? 102  LEU B CB  1 ? 
ATOM   3142 C CG  . LEU B 1 102 ? 24.184  29.580  -15.790 1.00 14.72 ? 102  LEU B CG  1 ? 
ATOM   3143 C CD1 . LEU B 1 102 ? 24.345  29.452  -14.276 1.00 15.76 ? 102  LEU B CD1 1 ? 
ATOM   3144 C CD2 . LEU B 1 102 ? 23.180  30.659  -16.116 1.00 14.12 ? 102  LEU B CD2 1 ? 
ATOM   3145 N N   . LEU B 1 103 ? 25.995  26.348  -16.274 1.00 12.97 ? 103  LEU B N   1 ? 
ATOM   3146 C CA  . LEU B 1 103 ? 25.598  25.026  -16.798 1.00 13.90 ? 103  LEU B CA  1 ? 
ATOM   3147 C C   . LEU B 1 103 ? 24.200  24.753  -16.259 1.00 14.39 ? 103  LEU B C   1 ? 
ATOM   3148 O O   . LEU B 1 103 ? 24.071  24.604  -15.038 1.00 15.97 ? 103  LEU B O   1 ? 
ATOM   3149 C CB  . LEU B 1 103 ? 26.655  24.025  -16.337 1.00 15.73 ? 103  LEU B CB  1 ? 
ATOM   3150 C CG  . LEU B 1 103 ? 26.441  22.568  -16.717 1.00 16.75 ? 103  LEU B CG  1 ? 
ATOM   3151 C CD1 . LEU B 1 103 ? 26.423  22.411  -18.233 1.00 17.40 ? 103  LEU B CD1 1 ? 
ATOM   3152 C CD2 . LEU B 1 103 ? 27.564  21.729  -16.130 1.00 16.21 ? 103  LEU B CD2 1 ? 
ATOM   3153 N N   . ILE B 1 104 ? 23.178  24.727  -17.103 1.00 13.65 ? 104  ILE B N   1 ? 
ATOM   3154 C CA  . ILE B 1 104 ? 21.784  24.643  -16.591 1.00 13.67 ? 104  ILE B CA  1 ? 
ATOM   3155 C C   . ILE B 1 104 ? 21.248  23.215  -16.671 1.00 14.06 ? 104  ILE B C   1 ? 
ATOM   3156 O O   . ILE B 1 104 ? 21.552  22.453  -17.593 1.00 14.46 ? 104  ILE B O   1 ? 
ATOM   3157 C CB  . ILE B 1 104 ? 20.827  25.647  -17.245 1.00 14.48 ? 104  ILE B CB  1 ? 
ATOM   3158 C CG1 . ILE B 1 104 ? 20.712  25.481  -18.761 1.00 14.62 ? 104  ILE B CG1 1 ? 
ATOM   3159 C CG2 . ILE B 1 104 ? 21.251  27.068  -16.857 1.00 15.63 ? 104  ILE B CG2 1 ? 
ATOM   3160 C CD1 . ILE B 1 104 ? 19.537  26.217  -19.345 1.00 14.57 ? 104  ILE B CD1 1 ? 
ATOM   3161 N N   A ASP B 1 105 ? 20.407  22.906  -15.692 0.50 13.85 ? 105  ASP B N   1 ? 
ATOM   3162 N N   B ASP B 1 105 ? 20.443  22.842  -15.682 0.50 14.19 ? 105  ASP B N   1 ? 
ATOM   3163 C CA  A ASP B 1 105 ? 19.639  21.645  -15.611 0.50 14.91 ? 105  ASP B CA  1 ? 
ATOM   3164 C CA  B ASP B 1 105 ? 19.732  21.540  -15.635 0.50 15.51 ? 105  ASP B CA  1 ? 
ATOM   3165 C C   A ASP B 1 105 ? 18.275  21.915  -16.228 0.50 13.98 ? 105  ASP B C   1 ? 
ATOM   3166 C C   B ASP B 1 105 ? 18.340  21.783  -16.232 0.50 14.29 ? 105  ASP B C   1 ? 
ATOM   3167 O O   A ASP B 1 105 ? 17.278  22.091  -15.498 0.50 15.06 ? 105  ASP B O   1 ? 
ATOM   3168 O O   B ASP B 1 105 ? 17.370  21.756  -15.459 0.50 16.10 ? 105  ASP B O   1 ? 
ATOM   3169 C CB  A ASP B 1 105 ? 19.533  21.181  -14.164 0.50 16.36 ? 105  ASP B CB  1 ? 
ATOM   3170 C CB  B ASP B 1 105 ? 19.681  21.063  -14.177 0.50 17.29 ? 105  ASP B CB  1 ? 
ATOM   3171 C CG  A ASP B 1 105 ? 19.032  19.765  -14.049 0.50 17.36 ? 105  ASP B CG  1 ? 
ATOM   3172 C CG  B ASP B 1 105 ? 20.137  19.651  -13.832 0.50 18.94 ? 105  ASP B CG  1 ? 
ATOM   3173 O OD1 A ASP B 1 105 ? 19.183  19.013  -15.022 0.50 17.32 ? 105  ASP B OD1 1 ? 
ATOM   3174 O OD1 B ASP B 1 105 ? 20.822  18.982  -14.652 0.50 20.36 ? 105  ASP B OD1 1 ? 
ATOM   3175 O OD2 A ASP B 1 105 ? 18.538  19.426  -12.955 0.50 19.00 ? 105  ASP B OD2 1 ? 
ATOM   3176 O OD2 B ASP B 1 105 ? 19.798  19.227  -12.711 0.50 20.02 ? 105  ASP B OD2 1 ? 
ATOM   3177 N N   . TYR B 1 106 ? 18.237  22.046  -17.549 1.00 13.40 ? 106  TYR B N   1 ? 
ATOM   3178 C CA  . TYR B 1 106 ? 16.971  22.360  -18.238 1.00 13.33 ? 106  TYR B CA  1 ? 
ATOM   3179 C C   . TYR B 1 106 ? 16.060  21.125  -18.173 1.00 13.44 ? 106  TYR B C   1 ? 
ATOM   3180 O O   . TYR B 1 106 ? 16.516  19.960  -18.009 1.00 14.98 ? 106  TYR B O   1 ? 
ATOM   3181 C CB  . TYR B 1 106 ? 17.193  22.812  -19.679 1.00 13.18 ? 106  TYR B CB  1 ? 
ATOM   3182 C CG  . TYR B 1 106 ? 17.877  21.842  -20.596 1.00 13.32 ? 106  TYR B CG  1 ? 
ATOM   3183 C CD1 . TYR B 1 106 ? 17.159  20.859  -21.243 1.00 13.24 ? 106  TYR B CD1 1 ? 
ATOM   3184 C CD2 . TYR B 1 106 ? 19.237  21.938  -20.860 1.00 13.35 ? 106  TYR B CD2 1 ? 
ATOM   3185 C CE1 . TYR B 1 106 ? 17.778  19.966  -22.091 1.00 13.34 ? 106  TYR B CE1 1 ? 
ATOM   3186 C CE2 . TYR B 1 106 ? 19.877  21.042  -21.697 1.00 13.35 ? 106  TYR B CE2 1 ? 
ATOM   3187 C CZ  . TYR B 1 106 ? 19.138  20.054  -22.328 1.00 13.23 ? 106  TYR B CZ  1 ? 
ATOM   3188 O OH  . TYR B 1 106 ? 19.708  19.170  -23.199 1.00 13.34 ? 106  TYR B OH  1 ? 
ATOM   3189 N N   . ARG B 1 107 ? 14.767  21.382  -18.282 1.00 14.10 ? 107  ARG B N   1 ? 
ATOM   3190 C CA  . ARG B 1 107 ? 13.757  20.308  -18.161 1.00 14.86 ? 107  ARG B CA  1 ? 
ATOM   3191 C C   . ARG B 1 107 ? 13.920  19.312  -19.311 1.00 15.09 ? 107  ARG B C   1 ? 
ATOM   3192 O O   . ARG B 1 107 ? 14.102  19.736  -20.470 1.00 14.90 ? 107  ARG B O   1 ? 
ATOM   3193 C CB  . ARG B 1 107 ? 12.358  20.912  -18.138 1.00 15.81 ? 107  ARG B CB  1 ? 
ATOM   3194 C CG  . ARG B 1 107 ? 12.006  21.471  -16.769 1.00 16.45 ? 107  ARG B CG  1 ? 
ATOM   3195 C CD  . ARG B 1 107 ? 10.729  22.247  -16.820 1.00 17.71 ? 107  ARG B CD  1 ? 
ATOM   3196 N NE  . ARG B 1 107 ? 10.813  23.421  -17.675 1.00 17.37 ? 107  ARG B NE  1 ? 
ATOM   3197 C CZ  . ARG B 1 107 ? 9.780   24.067  -18.193 1.00 19.50 ? 107  ARG B CZ  1 ? 
ATOM   3198 N NH1 . ARG B 1 107 ? 8.549   23.644  -17.973 1.00 22.75 ? 107  ARG B NH1 1 ? 
ATOM   3199 N NH2 . ARG B 1 107 ? 9.964   25.137  -18.936 1.00 19.03 ? 107  ARG B NH2 1 ? 
ATOM   3200 N N   . LEU B 1 108 ? 13.813  18.029  -18.989 1.00 15.19 ? 108  LEU B N   1 ? 
ATOM   3201 C CA  . LEU B 1 108 ? 14.060  16.911  -19.931 1.00 14.84 ? 108  LEU B CA  1 ? 
ATOM   3202 C C   . LEU B 1 108 ? 12.748  16.200  -20.262 1.00 15.11 ? 108  LEU B C   1 ? 
ATOM   3203 O O   . LEU B 1 108 ? 11.826  16.150  -19.414 1.00 14.90 ? 108  LEU B O   1 ? 
ATOM   3204 C CB  . LEU B 1 108 ? 15.067  15.928  -19.336 1.00 16.04 ? 108  LEU B CB  1 ? 
ATOM   3205 C CG  . LEU B 1 108 ? 16.483  16.473  -19.100 1.00 16.82 ? 108  LEU B CG  1 ? 
ATOM   3206 C CD1 . LEU B 1 108 ? 17.287  15.486  -18.283 1.00 18.26 ? 108  LEU B CD1 1 ? 
ATOM   3207 C CD2 . LEU B 1 108 ? 17.185  16.818  -20.407 1.00 16.84 ? 108  LEU B CD2 1 ? 
ATOM   3208 N N   . ALA B 1 109 ? 12.689  15.673  -21.472 1.00 13.96 ? 109  ALA B N   1 ? 
ATOM   3209 C CA  . ALA B 1 109 ? 11.640  14.731  -21.922 1.00 14.34 ? 109  ALA B CA  1 ? 
ATOM   3210 C C   . ALA B 1 109 ? 12.000  13.350  -21.384 1.00 13.92 ? 109  ALA B C   1 ? 
ATOM   3211 O O   . ALA B 1 109 ? 13.173  13.055  -21.114 1.00 13.60 ? 109  ALA B O   1 ? 
ATOM   3212 C CB  . ALA B 1 109 ? 11.559  14.739  -23.426 1.00 14.52 ? 109  ALA B CB  1 ? 
ATOM   3213 N N   . PRO B 1 110 ? 11.031  12.421  -21.235 1.00 15.11 ? 110  PRO B N   1 ? 
ATOM   3214 C CA  . PRO B 1 110 ? 9.624   12.629  -21.595 1.00 16.25 ? 110  PRO B CA  1 ? 
ATOM   3215 C C   . PRO B 1 110 ? 8.755   13.350  -20.559 1.00 16.79 ? 110  PRO B C   1 ? 
ATOM   3216 O O   . PRO B 1 110 ? 7.610   13.652  -20.862 1.00 18.89 ? 110  PRO B O   1 ? 
ATOM   3217 C CB  . PRO B 1 110 ? 9.130   11.183  -21.750 1.00 16.78 ? 110  PRO B CB  1 ? 
ATOM   3218 C CG  . PRO B 1 110 ? 9.955   10.419  -20.758 1.00 16.13 ? 110  PRO B CG  1 ? 
ATOM   3219 C CD  . PRO B 1 110 ? 11.332  11.043  -20.833 1.00 16.40 ? 110  PRO B CD  1 ? 
ATOM   3220 N N   . GLU B 1 111 ? 9.291   13.619  -19.378 1.00 16.00 ? 111  GLU B N   1 ? 
ATOM   3221 C CA  . GLU B 1 111 ? 8.541   14.333  -18.306 1.00 17.70 ? 111  GLU B CA  1 ? 
ATOM   3222 C C   . GLU B 1 111 ? 8.091   15.699  -18.830 1.00 19.37 ? 111  GLU B C   1 ? 
ATOM   3223 O O   . GLU B 1 111 ? 6.945   16.122  -18.548 1.00 18.57 ? 111  GLU B O   1 ? 
ATOM   3224 C CB  . GLU B 1 111 ? 9.389   14.490  -17.053 1.00 19.33 ? 111  GLU B CB  1 ? 
ATOM   3225 C CG  . GLU B 1 111 ? 9.774   13.169  -16.402 1.00 20.66 ? 111  GLU B CG  1 ? 
ATOM   3226 C CD  . GLU B 1 111 ? 11.052  12.499  -16.892 1.00 22.73 ? 111  GLU B CD  1 ? 
ATOM   3227 O OE1 . GLU B 1 111 ? 11.475  11.540  -16.234 1.00 25.33 ? 111  GLU B OE1 1 ? 
ATOM   3228 O OE2 . GLU B 1 111 ? 11.590  12.898  -17.966 1.00 19.83 ? 111  GLU B OE2 1 ? 
ATOM   3229 N N   . HIS B 1 112 ? 8.973   16.402  -19.536 1.00 16.43 ? 112  HIS B N   1 ? 
ATOM   3230 C CA  . HIS B 1 112 ? 8.737   17.795  -20.002 1.00 16.09 ? 112  HIS B CA  1 ? 
ATOM   3231 C C   . HIS B 1 112 ? 9.090   17.873  -21.478 1.00 17.41 ? 112  HIS B C   1 ? 
ATOM   3232 O O   . HIS B 1 112 ? 10.244  18.109  -21.860 1.00 16.30 ? 112  HIS B O   1 ? 
ATOM   3233 C CB  . HIS B 1 112 ? 9.577   18.799  -19.196 1.00 16.64 ? 112  HIS B CB  1 ? 
ATOM   3234 C CG  . HIS B 1 112 ? 9.416   18.642  -17.726 1.00 18.67 ? 112  HIS B CG  1 ? 
ATOM   3235 N ND1 . HIS B 1 112 ? 8.261   19.041  -17.092 1.00 21.93 ? 112  HIS B ND1 1 ? 
ATOM   3236 C CD2 . HIS B 1 112 ? 10.216  18.108  -16.779 1.00 21.40 ? 112  HIS B CD2 1 ? 
ATOM   3237 C CE1 . HIS B 1 112 ? 8.369   18.766  -15.802 1.00 23.04 ? 112  HIS B CE1 1 ? 
ATOM   3238 N NE2 . HIS B 1 112 ? 9.549   18.197  -15.588 1.00 24.02 ? 112  HIS B NE2 1 ? 
ATOM   3239 N N   . PRO B 1 113 ? 8.116   17.636  -22.369 1.00 16.96 ? 113  PRO B N   1 ? 
ATOM   3240 C CA  . PRO B 1 113 ? 8.383   17.705  -23.805 1.00 16.91 ? 113  PRO B CA  1 ? 
ATOM   3241 C C   . PRO B 1 113 ? 8.702   19.124  -24.285 1.00 15.44 ? 113  PRO B C   1 ? 
ATOM   3242 O O   . PRO B 1 113 ? 8.463   20.088  -23.562 1.00 15.21 ? 113  PRO B O   1 ? 
ATOM   3243 C CB  . PRO B 1 113 ? 7.068   17.225  -24.449 1.00 18.41 ? 113  PRO B CB  1 ? 
ATOM   3244 C CG  . PRO B 1 113 ? 6.393   16.443  -23.340 1.00 18.70 ? 113  PRO B CG  1 ? 
ATOM   3245 C CD  . PRO B 1 113 ? 6.769   17.130  -22.048 1.00 17.64 ? 113  PRO B CD  1 ? 
ATOM   3246 N N   . HIS B 1 114 ? 9.222   19.207  -25.507 1.00 14.35 ? 114  HIS B N   1 ? 
ATOM   3247 C CA  . HIS B 1 114 ? 9.360   20.480  -26.247 1.00 14.14 ? 114  HIS B CA  1 ? 
ATOM   3248 C C   . HIS B 1 114 ? 8.062   21.257  -26.061 1.00 15.17 ? 114  HIS B C   1 ? 
ATOM   3249 O O   . HIS B 1 114 ? 6.967   20.677  -26.214 1.00 16.18 ? 114  HIS B O   1 ? 
ATOM   3250 C CB  . HIS B 1 114 ? 9.630   20.214  -27.733 1.00 14.20 ? 114  HIS B CB  1 ? 
ATOM   3251 C CG  . HIS B 1 114 ? 9.755   21.477  -28.508 1.00 15.33 ? 114  HIS B CG  1 ? 
ATOM   3252 N ND1 . HIS B 1 114 ? 10.919  22.236  -28.495 1.00 15.95 ? 114  HIS B ND1 1 ? 
ATOM   3253 C CD2 . HIS B 1 114 ? 8.845   22.195  -29.198 1.00 16.65 ? 114  HIS B CD2 1 ? 
ATOM   3254 C CE1 . HIS B 1 114 ? 10.736  23.327  -29.213 1.00 15.87 ? 114  HIS B CE1 1 ? 
ATOM   3255 N NE2 . HIS B 1 114 ? 9.463   23.322  -29.671 1.00 16.14 ? 114  HIS B NE2 1 ? 
ATOM   3256 N N   . PRO B 1 115 ? 8.069   22.571  -25.747 1.00 15.72 ? 115  PRO B N   1 ? 
ATOM   3257 C CA  . PRO B 1 115 ? 9.256   23.432  -25.734 1.00 15.18 ? 115  PRO B CA  1 ? 
ATOM   3258 C C   . PRO B 1 115 ? 9.883   23.718  -24.360 1.00 14.34 ? 115  PRO B C   1 ? 
ATOM   3259 O O   . PRO B 1 115 ? 10.530  24.736  -24.215 1.00 15.50 ? 115  PRO B O   1 ? 
ATOM   3260 C CB  . PRO B 1 115 ? 8.645   24.724  -26.301 1.00 16.48 ? 115  PRO B CB  1 ? 
ATOM   3261 C CG  . PRO B 1 115 ? 7.293   24.794  -25.654 1.00 17.03 ? 115  PRO B CG  1 ? 
ATOM   3262 C CD  . PRO B 1 115 ? 6.825   23.350  -25.599 1.00 16.77 ? 115  PRO B CD  1 ? 
ATOM   3263 N N   . ALA B 1 116 ? 9.732   22.831  -23.381 1.00 13.38 ? 116  ALA B N   1 ? 
ATOM   3264 C CA  . ALA B 1 116 ? 10.239  23.104  -22.019 1.00 14.10 ? 116  ALA B CA  1 ? 
ATOM   3265 C C   . ALA B 1 116 ? 11.733  23.458  -22.086 1.00 13.39 ? 116  ALA B C   1 ? 
ATOM   3266 O O   . ALA B 1 116 ? 12.158  24.409  -21.398 1.00 14.88 ? 116  ALA B O   1 ? 
ATOM   3267 C CB  . ALA B 1 116 ? 9.972   21.928  -21.115 1.00 14.97 ? 116  ALA B CB  1 ? 
ATOM   3268 N N   . ALA B 1 117 ? 12.555  22.698  -22.816 1.00 12.28 ? 117  ALA B N   1 ? 
ATOM   3269 C CA  . ALA B 1 117 ? 14.018  22.945  -22.839 1.00 12.43 ? 117  ALA B CA  1 ? 
ATOM   3270 C C   . ALA B 1 117 ? 14.297  24.386  -23.309 1.00 12.63 ? 117  ALA B C   1 ? 
ATOM   3271 O O   . ALA B 1 117 ? 15.196  25.033  -22.761 1.00 13.57 ? 117  ALA B O   1 ? 
ATOM   3272 C CB  . ALA B 1 117 ? 14.690  21.955  -23.736 1.00 13.09 ? 117  ALA B CB  1 ? 
ATOM   3273 N N   . VAL B 1 118 ? 13.603  24.838  -24.351 1.00 13.94 ? 118  VAL B N   1 ? 
ATOM   3274 C CA  . VAL B 1 118 ? 13.835  26.176  -24.974 1.00 14.22 ? 118  VAL B CA  1 ? 
ATOM   3275 C C   . VAL B 1 118 ? 13.294  27.273  -24.043 1.00 14.64 ? 118  VAL B C   1 ? 
ATOM   3276 O O   . VAL B 1 118 ? 13.910  28.360  -23.941 1.00 15.27 ? 118  VAL B O   1 ? 
ATOM   3277 C CB  . VAL B 1 118 ? 13.201  26.303  -26.371 1.00 16.48 ? 118  VAL B CB  1 ? 
ATOM   3278 C CG1 . VAL B 1 118 ? 13.664  27.589  -27.012 1.00 17.55 ? 118  VAL B CG1 1 ? 
ATOM   3279 C CG2 . VAL B 1 118 ? 13.508  25.129  -27.285 1.00 17.92 ? 118  VAL B CG2 1 ? 
ATOM   3280 N N   . GLU B 1 119 ? 12.189  27.015  -23.354 1.00 14.89 ? 119  GLU B N   1 ? 
ATOM   3281 C CA  . GLU B 1 119 ? 11.706  27.960  -22.316 1.00 15.86 ? 119  GLU B CA  1 ? 
ATOM   3282 C C   . GLU B 1 119 ? 12.797  28.152  -21.269 1.00 16.20 ? 119  GLU B C   1 ? 
ATOM   3283 O O   . GLU B 1 119 ? 13.035  29.294  -20.846 1.00 16.06 ? 119  GLU B O   1 ? 
ATOM   3284 C CB  . GLU B 1 119 ? 10.428  27.450  -21.665 1.00 17.86 ? 119  GLU B CB  1 ? 
ATOM   3285 C CG  . GLU B 1 119 ? 9.259   27.451  -22.622 1.00 19.44 ? 119  GLU B CG  1 ? 
ATOM   3286 C CD  . GLU B 1 119 ? 8.009   26.838  -22.016 1.00 24.89 ? 119  GLU B CD  1 ? 
ATOM   3287 O OE1 . GLU B 1 119 ? 6.946   26.945  -22.655 1.00 28.17 ? 119  GLU B OE1 1 ? 
ATOM   3288 O OE2 . GLU B 1 119 ? 8.105   26.261  -20.913 1.00 29.40 ? 119  GLU B OE2 1 ? 
ATOM   3289 N N   . ASP B 1 120 ? 13.432  27.061  -20.845 1.00 14.48 ? 120  ASP B N   1 ? 
ATOM   3290 C CA  . ASP B 1 120 ? 14.465  27.126  -19.782 1.00 14.51 ? 120  ASP B CA  1 ? 
ATOM   3291 C C   . ASP B 1 120 ? 15.735  27.820  -20.291 1.00 13.73 ? 120  ASP B C   1 ? 
ATOM   3292 O O   . ASP B 1 120 ? 16.299  28.640  -19.538 1.00 14.32 ? 120  ASP B O   1 ? 
ATOM   3293 C CB  . ASP B 1 120 ? 14.773  25.742  -19.231 1.00 14.68 ? 120  ASP B CB  1 ? 
ATOM   3294 C CG  . ASP B 1 120 ? 13.659  25.175  -18.371 1.00 17.22 ? 120  ASP B CG  1 ? 
ATOM   3295 O OD1 . ASP B 1 120 ? 12.704  25.924  -18.057 1.00 18.59 ? 120  ASP B OD1 1 ? 
ATOM   3296 O OD2 . ASP B 1 120 ? 13.743  23.987  -18.054 1.00 18.06 ? 120  ASP B OD2 1 ? 
ATOM   3297 N N   . SER B 1 121 ? 16.231  27.489  -21.484 1.00 12.76 ? 121  SER B N   1 ? 
ATOM   3298 C CA  . SER B 1 121 ? 17.480  28.099  -21.997 1.00 13.28 ? 121  SER B CA  1 ? 
ATOM   3299 C C   . SER B 1 121 ? 17.263  29.608  -22.193 1.00 13.48 ? 121  SER B C   1 ? 
ATOM   3300 O O   . SER B 1 121 ? 18.144  30.386  -21.804 1.00 13.05 ? 121  SER B O   1 ? 
ATOM   3301 C CB  . SER B 1 121 ? 17.933  27.420  -23.258 1.00 13.67 ? 121  SER B CB  1 ? 
ATOM   3302 O OG  . SER B 1 121 ? 16.921  27.452  -24.236 1.00 15.26 ? 121  SER B OG  1 ? 
ATOM   3303 N N   . THR B 1 122 ? 16.124  30.020  -22.736 1.00 14.89 ? 122  THR B N   1 ? 
ATOM   3304 C CA  . THR B 1 122 ? 15.868  31.459  -22.970 1.00 14.85 ? 122  THR B CA  1 ? 
ATOM   3305 C C   . THR B 1 122 ? 15.720  32.153  -21.613 1.00 15.41 ? 122  THR B C   1 ? 
ATOM   3306 O O   . THR B 1 122 ? 16.280  33.253  -21.473 1.00 16.46 ? 122  THR B O   1 ? 
ATOM   3307 C CB  . THR B 1 122 ? 14.667  31.702  -23.887 1.00 15.85 ? 122  THR B CB  1 ? 
ATOM   3308 O OG1 . THR B 1 122 ? 13.508  31.133  -23.287 1.00 17.60 ? 122  THR B OG1 1 ? 
ATOM   3309 C CG2 . THR B 1 122 ? 14.882  31.169  -25.287 1.00 15.32 ? 122  THR B CG2 1 ? 
ATOM   3310 N N   . ARG B 1 123 ? 15.073  31.533  -20.617 1.00 15.08 ? 123  ARG B N   1 ? 
ATOM   3311 C CA  . ARG B 1 123 ? 14.930  32.155  -19.279 1.00 16.45 ? 123  ARG B CA  1 ? 
ATOM   3312 C C   . ARG B 1 123 ? 16.311  32.371  -18.656 1.00 16.61 ? 123  ARG B C   1 ? 
ATOM   3313 O O   . ARG B 1 123 ? 16.559  33.440  -18.053 1.00 16.18 ? 123  ARG B O   1 ? 
ATOM   3314 C CB  . ARG B 1 123 ? 14.065  31.280  -18.370 1.00 19.50 ? 123  ARG B CB  1 ? 
ATOM   3315 C CG  . ARG B 1 123 ? 13.894  31.825  -16.959 1.00 24.43 ? 123  ARG B CG  1 ? 
ATOM   3316 C CD  . ARG B 1 123 ? 13.078  33.101  -16.943 1.00 29.74 ? 123  ARG B CD  1 ? 
ATOM   3317 N NE  . ARG B 1 123 ? 13.268  33.897  -15.727 1.00 36.49 ? 123  ARG B NE  1 ? 
ATOM   3318 C CZ  . ARG B 1 123 ? 14.053  34.966  -15.631 1.00 37.41 ? 123  ARG B CZ  1 ? 
ATOM   3319 N NH1 . ARG B 1 123 ? 14.723  35.404  -16.685 1.00 37.49 ? 123  ARG B NH1 1 ? 
ATOM   3320 N NH2 . ARG B 1 123 ? 14.139  35.621  -14.482 1.00 39.52 ? 123  ARG B NH2 1 ? 
ATOM   3321 N N   . ALA B 1 124 ? 17.195  31.379  -18.745 1.00 14.11 ? 124  ALA B N   1 ? 
ATOM   3322 C CA  . ALA B 1 124 ? 18.531  31.471  -18.135 1.00 14.18 ? 124  ALA B CA  1 ? 
ATOM   3323 C C   . ALA B 1 124 ? 19.310  32.612  -18.784 1.00 13.95 ? 124  ALA B C   1 ? 
ATOM   3324 O O   . ALA B 1 124 ? 19.970  33.367  -18.064 1.00 13.71 ? 124  ALA B O   1 ? 
ATOM   3325 C CB  . ALA B 1 124 ? 19.266  30.160  -18.207 1.00 13.98 ? 124  ALA B CB  1 ? 
ATOM   3326 N N   . TYR B 1 125 ? 19.248  32.734  -20.107 1.00 13.73 ? 125  TYR B N   1 ? 
ATOM   3327 C CA  . TYR B 1 125 ? 19.965  33.796  -20.833 1.00 14.02 ? 125  TYR B CA  1 ? 
ATOM   3328 C C   . TYR B 1 125 ? 19.445  35.157  -20.373 1.00 15.30 ? 125  TYR B C   1 ? 
ATOM   3329 O O   . TYR B 1 125 ? 20.267  36.066  -20.075 1.00 14.28 ? 125  TYR B O   1 ? 
ATOM   3330 C CB  . TYR B 1 125 ? 19.785  33.635  -22.338 1.00 14.45 ? 125  TYR B CB  1 ? 
ATOM   3331 C CG  . TYR B 1 125 ? 20.582  34.638  -23.132 1.00 14.23 ? 125  TYR B CG  1 ? 
ATOM   3332 C CD1 . TYR B 1 125 ? 21.892  34.406  -23.496 1.00 15.33 ? 125  TYR B CD1 1 ? 
ATOM   3333 C CD2 . TYR B 1 125 ? 20.002  35.843  -23.491 1.00 14.73 ? 125  TYR B CD2 1 ? 
ATOM   3334 C CE1 . TYR B 1 125 ? 22.613  35.333  -24.234 1.00 16.46 ? 125  TYR B CE1 1 ? 
ATOM   3335 C CE2 . TYR B 1 125 ? 20.701  36.771  -24.241 1.00 14.45 ? 125  TYR B CE2 1 ? 
ATOM   3336 C CZ  . TYR B 1 125 ? 22.017  36.543  -24.571 1.00 15.91 ? 125  TYR B CZ  1 ? 
ATOM   3337 O OH  . TYR B 1 125 ? 22.700  37.461  -25.316 1.00 17.55 ? 125  TYR B OH  1 ? 
ATOM   3338 N N   A ARG B 1 126 ? 18.126  35.313  -20.310 0.50 15.83 ? 126  ARG B N   1 ? 
ATOM   3339 N N   B ARG B 1 126 ? 18.117  35.303  -20.324 0.50 15.44 ? 126  ARG B N   1 ? 
ATOM   3340 C CA  A ARG B 1 126 ? 17.511  36.598  -19.893 0.50 17.07 ? 126  ARG B CA  1 ? 
ATOM   3341 C CA  B ARG B 1 126 ? 17.445  36.553  -19.875 0.50 16.40 ? 126  ARG B CA  1 ? 
ATOM   3342 C C   A ARG B 1 126 ? 17.876  36.893  -18.435 0.50 16.76 ? 126  ARG B C   1 ? 
ATOM   3343 C C   B ARG B 1 126 ? 17.883  36.882  -18.445 0.50 16.40 ? 126  ARG B C   1 ? 
ATOM   3344 O O   A ARG B 1 126 ? 18.078  38.070  -18.123 0.50 17.08 ? 126  ARG B O   1 ? 
ATOM   3345 O O   B ARG B 1 126 ? 18.140  38.061  -18.163 0.50 16.80 ? 126  ARG B O   1 ? 
ATOM   3346 C CB  A ARG B 1 126 ? 16.015  36.557  -20.177 0.50 18.84 ? 126  ARG B CB  1 ? 
ATOM   3347 C CB  B ARG B 1 126 ? 15.926  36.424  -19.972 0.50 17.72 ? 126  ARG B CB  1 ? 
ATOM   3348 C CG  A ARG B 1 126 ? 15.727  36.463  -21.668 0.50 21.59 ? 126  ARG B CG  1 ? 
ATOM   3349 C CG  B ARG B 1 126 ? 15.407  36.451  -21.399 0.50 19.55 ? 126  ARG B CG  1 ? 
ATOM   3350 C CD  A ARG B 1 126 ? 14.251  36.448  -21.998 0.50 24.82 ? 126  ARG B CD  1 ? 
ATOM   3351 C CD  B ARG B 1 126 ? 13.922  36.752  -21.470 0.50 20.97 ? 126  ARG B CD  1 ? 
ATOM   3352 N NE  A ARG B 1 126 ? 13.719  37.801  -21.973 0.50 28.14 ? 126  ARG B NE  1 ? 
ATOM   3353 N NE  B ARG B 1 126 ? 13.116  35.950  -20.569 0.50 22.80 ? 126  ARG B NE  1 ? 
ATOM   3354 C CZ  A ARG B 1 126 ? 12.621  38.196  -22.598 0.50 30.54 ? 126  ARG B CZ  1 ? 
ATOM   3355 C CZ  B ARG B 1 126 ? 12.671  34.725  -20.840 0.50 23.31 ? 126  ARG B CZ  1 ? 
ATOM   3356 N NH1 A ARG B 1 126 ? 11.922  37.346  -23.332 0.50 31.41 ? 126  ARG B NH1 1 ? 
ATOM   3357 N NH1 B ARG B 1 126 ? 12.969  34.149  -21.990 0.50 23.69 ? 126  ARG B NH1 1 ? 
ATOM   3358 N NH2 A ARG B 1 126 ? 12.244  39.456  -22.502 0.50 32.05 ? 126  ARG B NH2 1 ? 
ATOM   3359 N NH2 B ARG B 1 126 ? 11.930  34.080  -19.958 0.50 22.21 ? 126  ARG B NH2 1 ? 
ATOM   3360 N N   . TRP B 1 127 ? 17.962  35.876  -17.579 1.00 15.69 ? 127  TRP B N   1 ? 
ATOM   3361 C CA  . TRP B 1 127 ? 18.417  36.042  -16.170 1.00 15.91 ? 127  TRP B CA  1 ? 
ATOM   3362 C C   . TRP B 1 127 ? 19.855  36.580  -16.145 1.00 16.40 ? 127  TRP B C   1 ? 
ATOM   3363 O O   . TRP B 1 127 ? 20.159  37.498  -15.340 1.00 16.79 ? 127  TRP B O   1 ? 
ATOM   3364 C CB  . TRP B 1 127 ? 18.294  34.714  -15.411 1.00 17.26 ? 127  TRP B CB  1 ? 
ATOM   3365 C CG  . TRP B 1 127 ? 18.804  34.800  -14.009 1.00 17.21 ? 127  TRP B CG  1 ? 
ATOM   3366 C CD1 . TRP B 1 127 ? 18.179  35.371  -12.938 1.00 19.24 ? 127  TRP B CD1 1 ? 
ATOM   3367 C CD2 . TRP B 1 127 ? 20.082  34.350  -13.534 1.00 18.00 ? 127  TRP B CD2 1 ? 
ATOM   3368 N NE1 . TRP B 1 127 ? 18.964  35.268  -11.820 1.00 19.64 ? 127  TRP B NE1 1 ? 
ATOM   3369 C CE2 . TRP B 1 127 ? 20.134  34.638  -12.147 1.00 18.08 ? 127  TRP B CE2 1 ? 
ATOM   3370 C CE3 . TRP B 1 127 ? 21.167  33.700  -14.128 1.00 17.86 ? 127  TRP B CE3 1 ? 
ATOM   3371 C CZ2 . TRP B 1 127 ? 21.243  34.315  -11.365 1.00 19.07 ? 127  TRP B CZ2 1 ? 
ATOM   3372 C CZ3 . TRP B 1 127 ? 22.256  33.363  -13.349 1.00 19.08 ? 127  TRP B CZ3 1 ? 
ATOM   3373 C CH2 . TRP B 1 127 ? 22.280  33.652  -11.979 1.00 19.01 ? 127  TRP B CH2 1 ? 
ATOM   3374 N N   . LEU B 1 128 ? 20.738  36.060  -16.989 1.00 15.14 ? 128  LEU B N   1 ? 
ATOM   3375 C CA  . LEU B 1 128 ? 22.123  36.570  -17.067 1.00 15.29 ? 128  LEU B CA  1 ? 
ATOM   3376 C C   . LEU B 1 128 ? 22.083  38.067  -17.408 1.00 17.71 ? 128  LEU B C   1 ? 
ATOM   3377 O O   . LEU B 1 128 ? 22.832  38.843  -16.770 1.00 17.67 ? 128  LEU B O   1 ? 
ATOM   3378 C CB  . LEU B 1 128 ? 22.921  35.774  -18.098 1.00 15.16 ? 128  LEU B CB  1 ? 
ATOM   3379 C CG  . LEU B 1 128 ? 23.332  34.367  -17.660 1.00 15.29 ? 128  LEU B CG  1 ? 
ATOM   3380 C CD1 . LEU B 1 128 ? 23.898  33.595  -18.842 1.00 15.70 ? 128  LEU B CD1 1 ? 
ATOM   3381 C CD2 . LEU B 1 128 ? 24.371  34.399  -16.545 1.00 15.75 ? 128  LEU B CD2 1 ? 
ATOM   3382 N N   . LEU B 1 129 ? 21.266  38.464  -18.383 1.00 17.48 ? 129  LEU B N   1 ? 
ATOM   3383 C CA  . LEU B 1 129 ? 21.151  39.904  -18.761 1.00 19.03 ? 129  LEU B CA  1 ? 
ATOM   3384 C C   . LEU B 1 129 ? 20.605  40.695  -17.565 1.00 19.33 ? 129  LEU B C   1 ? 
ATOM   3385 O O   . LEU B 1 129 ? 21.094  41.816  -17.325 1.00 19.27 ? 129  LEU B O   1 ? 
ATOM   3386 C CB  . LEU B 1 129 ? 20.218  40.079  -19.962 1.00 18.88 ? 129  LEU B CB  1 ? 
ATOM   3387 C CG  . LEU B 1 129 ? 20.714  39.503  -21.283 1.00 20.30 ? 129  LEU B CG  1 ? 
ATOM   3388 C CD1 . LEU B 1 129 ? 19.752  39.863  -22.403 1.00 20.82 ? 129  LEU B CD1 1 ? 
ATOM   3389 C CD2 . LEU B 1 129 ? 22.100  39.984  -21.639 1.00 20.97 ? 129  LEU B CD2 1 ? 
ATOM   3390 N N   . GLU B 1 130 ? 19.596  40.173  -16.876 1.00 19.76 ? 130  GLU B N   1 ? 
ATOM   3391 C CA  . GLU B 1 130 ? 18.952  40.860  -15.718 1.00 23.15 ? 130  GLU B CA  1 ? 
ATOM   3392 C C   . GLU B 1 130 ? 19.991  41.109  -14.623 1.00 22.72 ? 130  GLU B C   1 ? 
ATOM   3393 O O   . GLU B 1 130 ? 19.850  42.139  -13.916 1.00 23.43 ? 130  GLU B O   1 ? 
ATOM   3394 C CB  . GLU B 1 130 ? 17.822  40.045  -15.098 1.00 27.07 ? 130  GLU B CB  1 ? 
ATOM   3395 C CG  . GLU B 1 130 ? 16.566  39.990  -15.939 1.00 34.04 ? 130  GLU B CG  1 ? 
ATOM   3396 C CD  . GLU B 1 130 ? 15.564  38.944  -15.472 1.00 39.48 ? 130  GLU B CD  1 ? 
ATOM   3397 O OE1 . GLU B 1 130 ? 15.560  38.639  -14.255 1.00 43.94 ? 130  GLU B OE1 1 ? 
ATOM   3398 O OE2 . GLU B 1 130 ? 14.800  38.420  -16.329 1.00 44.64 ? 130  GLU B OE2 1 ? 
ATOM   3399 N N   . THR B 1 131 ? 20.973  40.230  -14.465 1.00 19.41 ? 131  THR B N   1 ? 
ATOM   3400 C CA  . THR B 1 131 ? 21.963  40.317  -13.356 1.00 21.16 ? 131  THR B CA  1 ? 
ATOM   3401 C C   . THR B 1 131 ? 23.205  41.085  -13.834 1.00 22.19 ? 131  THR B C   1 ? 
ATOM   3402 O O   . THR B 1 131 ? 24.110  41.277  -13.020 1.00 27.19 ? 131  THR B O   1 ? 
ATOM   3403 C CB  . THR B 1 131 ? 22.237  38.940  -12.741 1.00 22.53 ? 131  THR B CB  1 ? 
ATOM   3404 O OG1 . THR B 1 131 ? 22.771  38.069  -13.742 1.00 25.41 ? 131  THR B OG1 1 ? 
ATOM   3405 C CG2 . THR B 1 131 ? 20.986  38.328  -12.148 1.00 22.31 ? 131  THR B CG2 1 ? 
ATOM   3406 N N   . GLY B 1 132 ? 23.219  41.571  -15.080 1.00 21.01 ? 132  GLY B N   1 ? 
ATOM   3407 C CA  . GLY B 1 132 ? 24.187  42.558  -15.581 1.00 21.54 ? 132  GLY B CA  1 ? 
ATOM   3408 C C   . GLY B 1 132 ? 25.191  42.008  -16.575 1.00 21.27 ? 132  GLY B C   1 ? 
ATOM   3409 O O   . GLY B 1 132 ? 26.131  42.747  -16.891 1.00 21.52 ? 132  GLY B O   1 ? 
ATOM   3410 N N   . SER B 1 133 ? 25.048  40.772  -17.082 1.00 19.76 ? 133  SER B N   1 ? 
ATOM   3411 C CA  . SER B 1 133 ? 25.984  40.229  -18.094 1.00 19.36 ? 133  SER B CA  1 ? 
ATOM   3412 C C   . SER B 1 133 ? 25.854  41.051  -19.377 1.00 19.03 ? 133  SER B C   1 ? 
ATOM   3413 O O   . SER B 1 133 ? 24.735  41.489  -19.682 1.00 21.71 ? 133  SER B O   1 ? 
ATOM   3414 C CB  . SER B 1 133 ? 25.757  38.762  -18.379 1.00 20.20 ? 133  SER B CB  1 ? 
ATOM   3415 O OG  . SER B 1 133 ? 25.953  37.999  -17.199 1.00 22.42 ? 133  SER B OG  1 ? 
ATOM   3416 N N   . ASP B 1 134 ? 26.960  41.266  -20.078 1.00 17.50 ? 134  ASP B N   1 ? 
ATOM   3417 C CA  . ASP B 1 134 ? 26.927  42.047  -21.337 1.00 21.16 ? 134  ASP B CA  1 ? 
ATOM   3418 C C   . ASP B 1 134 ? 26.996  41.117  -22.538 1.00 18.01 ? 134  ASP B C   1 ? 
ATOM   3419 O O   . ASP B 1 134 ? 27.921  40.322  -22.633 1.00 18.39 ? 134  ASP B O   1 ? 
ATOM   3420 C CB  . ASP B 1 134 ? 28.044  43.078  -21.391 1.00 24.20 ? 134  ASP B CB  1 ? 
ATOM   3421 C CG  . ASP B 1 134 ? 27.741  44.101  -22.470 1.00 29.15 ? 134  ASP B CG  1 ? 
ATOM   3422 O OD1 . ASP B 1 134 ? 27.833  43.744  -23.656 1.00 26.23 ? 134  ASP B OD1 1 ? 
ATOM   3423 O OD2 . ASP B 1 134 ? 27.303  45.222  -22.107 1.00 35.96 ? 134  ASP B OD2 1 ? 
ATOM   3424 N N   . PRO B 1 135 ? 26.055  41.239  -23.500 1.00 19.42 ? 135  PRO B N   1 ? 
ATOM   3425 C CA  . PRO B 1 135 ? 26.071  40.384  -24.697 1.00 18.51 ? 135  PRO B CA  1 ? 
ATOM   3426 C C   . PRO B 1 135 ? 27.412  40.326  -25.436 1.00 18.27 ? 135  PRO B C   1 ? 
ATOM   3427 O O   . PRO B 1 135 ? 27.778  39.272  -25.944 1.00 18.90 ? 135  PRO B O   1 ? 
ATOM   3428 C CB  . PRO B 1 135 ? 24.952  41.002  -25.548 1.00 19.24 ? 135  PRO B CB  1 ? 
ATOM   3429 C CG  . PRO B 1 135 ? 23.986  41.547  -24.537 1.00 19.93 ? 135  PRO B CG  1 ? 
ATOM   3430 C CD  . PRO B 1 135 ? 24.897  42.144  -23.483 1.00 19.67 ? 135  PRO B CD  1 ? 
ATOM   3431 N N   . LYS B 1 136 ? 28.173  41.433  -25.434 1.00 18.37 ? 136  LYS B N   1 ? 
ATOM   3432 C CA  . LYS B 1 136 ? 29.476  41.485  -26.131 1.00 19.03 ? 136  LYS B CA  1 ? 
ATOM   3433 C C   . LYS B 1 136 ? 30.490  40.562  -25.464 1.00 16.75 ? 136  LYS B C   1 ? 
ATOM   3434 O O   . LYS B 1 136 ? 31.529  40.303  -26.070 1.00 16.89 ? 136  LYS B O   1 ? 
ATOM   3435 C CB  . LYS B 1 136 ? 30.026  42.915  -26.132 1.00 21.80 ? 136  LYS B CB  1 ? 
ATOM   3436 C CG  . LYS B 1 136 ? 29.271  43.879  -27.021 1.00 24.59 ? 136  LYS B CG  1 ? 
ATOM   3437 C CD  . LYS B 1 136 ? 29.823  45.305  -26.923 1.00 26.81 ? 136  LYS B CD  1 ? 
ATOM   3438 C CE  . LYS B 1 136 ? 29.616  45.950  -25.572 1.00 28.68 ? 136  LYS B CE  1 ? 
ATOM   3439 N NZ  . LYS B 1 136 ? 28.176  46.074  -25.247 1.00 31.00 ? 136  LYS B NZ  1 ? 
ATOM   3440 N N   . ARG B 1 137 ? 30.214  40.109  -24.231 1.00 16.10 ? 137  ARG B N   1 ? 
ATOM   3441 C CA  . ARG B 1 137 ? 31.121  39.220  -23.479 1.00 17.89 ? 137  ARG B CA  1 ? 
ATOM   3442 C C   . ARG B 1 137 ? 30.384  37.934  -23.094 1.00 16.69 ? 137  ARG B C   1 ? 
ATOM   3443 O O   . ARG B 1 137 ? 30.789  37.252  -22.119 1.00 17.24 ? 137  ARG B O   1 ? 
ATOM   3444 C CB  . ARG B 1 137 ? 31.677  39.958  -22.263 1.00 20.53 ? 137  ARG B CB  1 ? 
ATOM   3445 C CG  . ARG B 1 137 ? 32.753  40.963  -22.658 1.00 24.24 ? 137  ARG B CG  1 ? 
ATOM   3446 C CD  . ARG B 1 137 ? 33.418  41.684  -21.503 1.00 30.37 ? 137  ARG B CD  1 ? 
ATOM   3447 N NE  . ARG B 1 137 ? 32.469  42.463  -20.732 1.00 36.56 ? 137  ARG B NE  1 ? 
ATOM   3448 C CZ  . ARG B 1 137 ? 32.006  43.661  -21.075 1.00 41.71 ? 137  ARG B CZ  1 ? 
ATOM   3449 N NH1 . ARG B 1 137 ? 32.383  44.237  -22.207 1.00 45.34 ? 137  ARG B NH1 1 ? 
ATOM   3450 N NH2 . ARG B 1 137 ? 31.122  44.259  -20.293 1.00 43.90 ? 137  ARG B NH2 1 ? 
ATOM   3451 N N   . MET B 1 138 ? 29.365  37.578  -23.865 1.00 15.23 ? 138  MET B N   1 ? 
ATOM   3452 C CA  . MET B 1 138 ? 28.599  36.333  -23.626 1.00 15.25 ? 138  MET B CA  1 ? 
ATOM   3453 C C   . MET B 1 138 ? 28.705  35.393  -24.828 1.00 15.53 ? 138  MET B C   1 ? 
ATOM   3454 O O   . MET B 1 138 ? 29.010  35.841  -25.945 1.00 14.78 ? 138  MET B O   1 ? 
ATOM   3455 C CB  . MET B 1 138 ? 27.127  36.639  -23.383 1.00 15.64 ? 138  MET B CB  1 ? 
ATOM   3456 C CG  . MET B 1 138 ? 26.841  37.402  -22.086 1.00 16.73 ? 138  MET B CG  1 ? 
ATOM   3457 S SD  . MET B 1 138 ? 25.160  38.062  -21.968 1.00 20.62 ? 138  MET B SD  1 ? 
ATOM   3458 C CE  . MET B 1 138 ? 24.250  36.580  -21.530 1.00 22.17 ? 138  MET B CE  1 ? 
ATOM   3459 N N   . ALA B 1 139 ? 28.427  34.112  -24.594 1.00 13.65 ? 139  ALA B N   1 ? 
ATOM   3460 C CA  . ALA B 1 139 ? 28.255  33.118  -25.663 1.00 13.40 ? 139  ALA B CA  1 ? 
ATOM   3461 C C   . ALA B 1 139 ? 27.281  32.062  -25.167 1.00 13.48 ? 139  ALA B C   1 ? 
ATOM   3462 O O   . ALA B 1 139 ? 27.083  31.954  -23.955 1.00 12.99 ? 139  ALA B O   1 ? 
ATOM   3463 C CB  . ALA B 1 139 ? 29.574  32.522  -26.065 1.00 14.64 ? 139  ALA B CB  1 ? 
ATOM   3464 N N   . ILE B 1 140 ? 26.640  31.379  -26.103 1.00 11.69 ? 140  ILE B N   1 ? 
ATOM   3465 C CA  . ILE B 1 140 ? 25.821  30.176  -25.807 1.00 12.06 ? 140  ILE B CA  1 ? 
ATOM   3466 C C   . ILE B 1 140 ? 26.520  29.016  -26.497 1.00 12.41 ? 140  ILE B C   1 ? 
ATOM   3467 O O   . ILE B 1 140 ? 26.957  29.158  -27.659 1.00 12.94 ? 140  ILE B O   1 ? 
ATOM   3468 C CB  . ILE B 1 140 ? 24.351  30.317  -26.247 1.00 11.88 ? 140  ILE B CB  1 ? 
ATOM   3469 C CG1 . ILE B 1 140 ? 23.695  31.575  -25.674 1.00 12.93 ? 140  ILE B CG1 1 ? 
ATOM   3470 C CG2 . ILE B 1 140 ? 23.566  29.076  -25.850 1.00 12.21 ? 140  ILE B CG2 1 ? 
ATOM   3471 C CD1 . ILE B 1 140 ? 22.255  31.819  -26.101 1.00 14.12 ? 140  ILE B CD1 1 ? 
ATOM   3472 N N   . ALA B 1 141 ? 26.735  27.922  -25.784 1.00 12.06 ? 141  ALA B N   1 ? 
ATOM   3473 C CA  . ALA B 1 141 ? 27.441  26.748  -26.326 1.00 11.84 ? 141  ALA B CA  1 ? 
ATOM   3474 C C   . ALA B 1 141 ? 26.688  25.497  -25.913 1.00 11.84 ? 141  ALA B C   1 ? 
ATOM   3475 O O   . ALA B 1 141 ? 26.048  25.479  -24.837 1.00 11.79 ? 141  ALA B O   1 ? 
ATOM   3476 C CB  . ALA B 1 141 ? 28.852  26.698  -25.833 1.00 12.04 ? 141  ALA B CB  1 ? 
ATOM   3477 N N   . GLY B 1 142 ? 26.770  24.478  -26.737 1.00 11.34 ? 142  GLY B N   1 ? 
ATOM   3478 C CA  . GLY B 1 142 ? 26.152  23.205  -26.350 1.00 11.39 ? 142  GLY B CA  1 ? 
ATOM   3479 C C   . GLY B 1 142 ? 26.552  22.084  -27.260 1.00 11.49 ? 142  GLY B C   1 ? 
ATOM   3480 O O   . GLY B 1 142 ? 26.991  22.326  -28.415 1.00 11.66 ? 142  GLY B O   1 ? 
ATOM   3481 N N   . ASP B 1 143 ? 26.394  20.863  -26.772 1.00 10.73 ? 143  ASP B N   1 ? 
ATOM   3482 C CA  . ASP B 1 143 ? 26.808  19.659  -27.514 1.00 11.98 ? 143  ASP B CA  1 ? 
ATOM   3483 C C   . ASP B 1 143 ? 25.553  18.886  -27.909 1.00 11.88 ? 143  ASP B C   1 ? 
ATOM   3484 O O   . ASP B 1 143 ? 24.647  18.741  -27.075 1.00 12.09 ? 143  ASP B O   1 ? 
ATOM   3485 C CB  . ASP B 1 143 ? 27.765  18.770  -26.715 1.00 12.39 ? 143  ASP B CB  1 ? 
ATOM   3486 C CG  . ASP B 1 143 ? 27.206  18.351  -25.381 1.00 13.19 ? 143  ASP B CG  1 ? 
ATOM   3487 O OD1 . ASP B 1 143 ? 26.988  19.232  -24.513 1.00 13.86 ? 143  ASP B OD1 1 ? 
ATOM   3488 O OD2 . ASP B 1 143 ? 26.940  17.124  -25.233 1.00 13.88 ? 143  ASP B OD2 1 ? 
ATOM   3489 N N   . ALA B 1 144 ? 25.531  18.376  -29.130 1.00 11.95 ? 144  ALA B N   1 ? 
ATOM   3490 C CA  . ALA B 1 144 ? 24.543  17.356  -29.561 1.00 12.49 ? 144  ALA B CA  1 ? 
ATOM   3491 C C   . ALA B 1 144 ? 23.136  17.958  -29.437 1.00 11.78 ? 144  ALA B C   1 ? 
ATOM   3492 O O   . ALA B 1 144 ? 22.887  19.003  -30.061 1.00 11.60 ? 144  ALA B O   1 ? 
ATOM   3493 C CB  . ALA B 1 144 ? 24.801  16.095  -28.780 1.00 13.31 ? 144  ALA B CB  1 ? 
ATOM   3494 N N   . ALA B 1 145 ? 22.192  17.380  -28.688 1.00 11.07 ? 145  ALA B N   1 ? 
ATOM   3495 C CA  . ALA B 1 145 ? 20.872  18.024  -28.485 1.00 11.33 ? 145  ALA B CA  1 ? 
ATOM   3496 C C   . ALA B 1 145 ? 21.065  19.469  -28.006 1.00 11.30 ? 145  ALA B C   1 ? 
ATOM   3497 O O   . ALA B 1 145 ? 20.281  20.361  -28.400 1.00 12.30 ? 145  ALA B O   1 ? 
ATOM   3498 C CB  . ALA B 1 145 ? 20.013  17.255  -27.509 1.00 11.92 ? 145  ALA B CB  1 ? 
ATOM   3499 N N   . GLY B 1 146 ? 22.050  19.709  -27.149 1.00 11.33 ? 146  GLY B N   1 ? 
ATOM   3500 C CA  . GLY B 1 146 ? 22.343  21.050  -26.626 1.00 11.42 ? 146  GLY B CA  1 ? 
ATOM   3501 C C   . GLY B 1 146 ? 22.883  21.986  -27.697 1.00 11.77 ? 146  GLY B C   1 ? 
ATOM   3502 O O   . GLY B 1 146 ? 22.716  23.206  -27.536 1.00 11.66 ? 146  GLY B O   1 ? 
ATOM   3503 N N   . GLY B 1 147 ? 23.499  21.442  -28.744 1.00 11.10 ? 147  GLY B N   1 ? 
ATOM   3504 C CA  . GLY B 1 147 ? 23.941  22.251  -29.895 1.00 11.64 ? 147  GLY B CA  1 ? 
ATOM   3505 C C   . GLY B 1 147 ? 22.741  22.673  -30.720 1.00 12.22 ? 147  GLY B C   1 ? 
ATOM   3506 O O   . GLY B 1 147 ? 22.667  23.842  -31.139 1.00 12.64 ? 147  GLY B O   1 ? 
ATOM   3507 N N   . GLY B 1 148 ? 21.777  21.773  -30.944 1.00 12.46 ? 148  GLY B N   1 ? 
ATOM   3508 C CA  . GLY B 1 148 ? 20.477  22.174  -31.500 1.00 12.65 ? 148  GLY B CA  1 ? 
ATOM   3509 C C   . GLY B 1 148 ? 19.778  23.176  -30.603 1.00 12.02 ? 148  GLY B C   1 ? 
ATOM   3510 O O   . GLY B 1 148 ? 19.226  24.173  -31.116 1.00 12.20 ? 148  GLY B O   1 ? 
ATOM   3511 N N   . LEU B 1 149 ? 19.806  22.969  -29.293 1.00 11.35 ? 149  LEU B N   1 ? 
ATOM   3512 C CA  . LEU B 1 149 ? 19.102  23.880  -28.358 1.00 11.10 ? 149  LEU B CA  1 ? 
ATOM   3513 C C   . LEU B 1 149 ? 19.757  25.269  -28.409 1.00 11.18 ? 149  LEU B C   1 ? 
ATOM   3514 O O   . LEU B 1 149 ? 19.048  26.270  -28.281 1.00 12.74 ? 149  LEU B O   1 ? 
ATOM   3515 C CB  . LEU B 1 149 ? 19.128  23.300  -26.946 1.00 11.71 ? 149  LEU B CB  1 ? 
ATOM   3516 C CG  . LEU B 1 149 ? 18.300  24.046  -25.901 1.00 12.65 ? 149  LEU B CG  1 ? 
ATOM   3517 C CD1 . LEU B 1 149 ? 16.854  24.185  -26.329 1.00 12.70 ? 149  LEU B CD1 1 ? 
ATOM   3518 C CD2 . LEU B 1 149 ? 18.350  23.328  -24.553 1.00 13.37 ? 149  LEU B CD2 1 ? 
ATOM   3519 N N   . THR B 1 150 ? 21.070  25.326  -28.611 1.00 12.01 ? 150  THR B N   1 ? 
ATOM   3520 C CA  . THR B 1 150 ? 21.795  26.612  -28.738 1.00 12.20 ? 150  THR B CA  1 ? 
ATOM   3521 C C   . THR B 1 150 ? 21.204  27.407  -29.898 1.00 11.89 ? 150  THR B C   1 ? 
ATOM   3522 O O   . THR B 1 150 ? 20.883  28.584  -29.720 1.00 11.77 ? 150  THR B O   1 ? 
ATOM   3523 C CB  . THR B 1 150 ? 23.290  26.365  -28.914 1.00 12.09 ? 150  THR B CB  1 ? 
ATOM   3524 O OG1 . THR B 1 150 ? 23.830  25.837  -27.691 1.00 12.43 ? 150  THR B OG1 1 ? 
ATOM   3525 C CG2 . THR B 1 150 ? 24.046  27.609  -29.338 1.00 13.79 ? 150  THR B CG2 1 ? 
ATOM   3526 N N   . VAL B 1 151 ? 21.055  26.762  -31.048 1.00 12.30 ? 151  VAL B N   1 ? 
ATOM   3527 C CA  . VAL B 1 151 ? 20.520  27.472  -32.242 1.00 12.32 ? 151  VAL B CA  1 ? 
ATOM   3528 C C   . VAL B 1 151 ? 19.077  27.890  -31.976 1.00 11.97 ? 151  VAL B C   1 ? 
ATOM   3529 O O   . VAL B 1 151 ? 18.732  29.050  -32.255 1.00 12.89 ? 151  VAL B O   1 ? 
ATOM   3530 C CB  . VAL B 1 151 ? 20.647  26.587  -33.486 1.00 12.87 ? 151  VAL B CB  1 ? 
ATOM   3531 C CG1 . VAL B 1 151 ? 20.077  27.295  -34.689 1.00 13.08 ? 151  VAL B CG1 1 ? 
ATOM   3532 C CG2 . VAL B 1 151 ? 22.096  26.200  -33.730 1.00 14.50 ? 151  VAL B CG2 1 ? 
ATOM   3533 N N   . ALA B 1 152 ? 18.238  26.982  -31.462 1.00 11.85 ? 152  ALA B N   1 ? 
ATOM   3534 C CA  . ALA B 1 152 ? 16.827  27.312  -31.194 1.00 12.18 ? 152  ALA B CA  1 ? 
ATOM   3535 C C   . ALA B 1 152 ? 16.738  28.477  -30.195 1.00 12.55 ? 152  ALA B C   1 ? 
ATOM   3536 O O   . ALA B 1 152 ? 15.878  29.341  -30.373 1.00 12.98 ? 152  ALA B O   1 ? 
ATOM   3537 C CB  . ALA B 1 152 ? 16.112  26.110  -30.659 1.00 13.03 ? 152  ALA B CB  1 ? 
ATOM   3538 N N   . THR B 1 153 ? 17.607  28.497  -29.173 1.00 11.59 ? 153  THR B N   1 ? 
ATOM   3539 C CA  . THR B 1 153 ? 17.598  29.558  -28.138 1.00 12.14 ? 153  THR B CA  1 ? 
ATOM   3540 C C   . THR B 1 153 ? 17.885  30.904  -28.817 1.00 11.97 ? 153  THR B C   1 ? 
ATOM   3541 O O   . THR B 1 153 ? 17.178  31.888  -28.519 1.00 12.18 ? 153  THR B O   1 ? 
ATOM   3542 C CB  . THR B 1 153 ? 18.606  29.255  -27.034 1.00 12.71 ? 153  THR B CB  1 ? 
ATOM   3543 O OG1 . THR B 1 153 ? 18.282  27.985  -26.460 1.00 15.02 ? 153  THR B OG1 1 ? 
ATOM   3544 C CG2 . THR B 1 153 ? 18.573  30.312  -25.957 1.00 12.78 ? 153  THR B CG2 1 ? 
ATOM   3545 N N   . LEU B 1 154 ? 18.880  30.939  -29.686 1.00 12.17 ? 154  LEU B N   1 ? 
ATOM   3546 C CA  . LEU B 1 154 ? 19.234  32.188  -30.398 1.00 12.72 ? 154  LEU B CA  1 ? 
ATOM   3547 C C   . LEU B 1 154 ? 18.053  32.662  -31.248 1.00 12.61 ? 154  LEU B C   1 ? 
ATOM   3548 O O   . LEU B 1 154 ? 17.751  33.870  -31.244 1.00 13.37 ? 154  LEU B O   1 ? 
ATOM   3549 C CB  . LEU B 1 154 ? 20.471  31.942  -31.254 1.00 12.99 ? 154  LEU B CB  1 ? 
ATOM   3550 C CG  . LEU B 1 154 ? 21.756  31.660  -30.485 1.00 13.67 ? 154  LEU B CG  1 ? 
ATOM   3551 C CD1 . LEU B 1 154 ? 22.799  31.090  -31.417 1.00 13.75 ? 154  LEU B CD1 1 ? 
ATOM   3552 C CD2 . LEU B 1 154 ? 22.267  32.923  -29.814 1.00 14.15 ? 154  LEU B CD2 1 ? 
ATOM   3553 N N   . VAL B 1 155 ? 17.416  31.755  -31.981 1.00 13.51 ? 155  VAL B N   1 ? 
ATOM   3554 C CA  . VAL B 1 155 ? 16.249  32.124  -32.823 1.00 14.37 ? 155  VAL B CA  1 ? 
ATOM   3555 C C   . VAL B 1 155 ? 15.143  32.701  -31.938 1.00 14.80 ? 155  VAL B C   1 ? 
ATOM   3556 O O   . VAL B 1 155 ? 14.599  33.794  -32.274 1.00 15.86 ? 155  VAL B O   1 ? 
ATOM   3557 C CB  . VAL B 1 155 ? 15.784  30.918  -33.653 1.00 13.99 ? 155  VAL B CB  1 ? 
ATOM   3558 C CG1 . VAL B 1 155 ? 14.435  31.204  -34.320 1.00 15.59 ? 155  VAL B CG1 1 ? 
ATOM   3559 C CG2 . VAL B 1 155 ? 16.854  30.550  -34.669 1.00 14.08 ? 155  VAL B CG2 1 ? 
ATOM   3560 N N   . ALA B 1 156 ? 14.788  32.020  -30.853 1.00 13.80 ? 156  ALA B N   1 ? 
ATOM   3561 C CA  . ALA B 1 156 ? 13.694  32.442  -29.965 1.00 14.97 ? 156  ALA B CA  1 ? 
ATOM   3562 C C   . ALA B 1 156 ? 14.060  33.803  -29.346 1.00 15.14 ? 156  ALA B C   1 ? 
ATOM   3563 O O   . ALA B 1 156 ? 13.180  34.687  -29.242 1.00 16.85 ? 156  ALA B O   1 ? 
ATOM   3564 C CB  . ALA B 1 156 ? 13.443  31.402  -28.905 1.00 15.07 ? 156  ALA B CB  1 ? 
ATOM   3565 N N   . LEU B 1 157 ? 15.299  33.971  -28.880 1.00 14.59 ? 157  LEU B N   1 ? 
ATOM   3566 C CA  . LEU B 1 157 ? 15.721  35.272  -28.275 1.00 14.85 ? 157  LEU B CA  1 ? 
ATOM   3567 C C   . LEU B 1 157 ? 15.595  36.384  -29.320 1.00 14.71 ? 157  LEU B C   1 ? 
ATOM   3568 O O   . LEU B 1 157 ? 15.076  37.474  -28.965 1.00 16.86 ? 157  LEU B O   1 ? 
ATOM   3569 C CB  . LEU B 1 157 ? 17.159  35.196  -27.771 1.00 15.20 ? 157  LEU B CB  1 ? 
ATOM   3570 C CG  . LEU B 1 157 ? 17.394  34.304  -26.550 1.00 14.98 ? 157  LEU B CG  1 ? 
ATOM   3571 C CD1 . LEU B 1 157 ? 18.888  34.096  -26.362 1.00 15.28 ? 157  LEU B CD1 1 ? 
ATOM   3572 C CD2 . LEU B 1 157 ? 16.758  34.903  -25.319 1.00 15.21 ? 157  LEU B CD2 1 ? 
ATOM   3573 N N   . ARG B 1 158 ? 16.093  36.170  -30.524 1.00 15.61 ? 158  ARG B N   1 ? 
ATOM   3574 C CA  . ARG B 1 158 ? 16.046  37.205  -31.584 1.00 17.91 ? 158  ARG B CA  1 ? 
ATOM   3575 C C   . ARG B 1 158 ? 14.587  37.589  -31.836 1.00 20.06 ? 158  ARG B C   1 ? 
ATOM   3576 O O   . ARG B 1 158 ? 14.285  38.802  -31.925 1.00 20.66 ? 158  ARG B O   1 ? 
ATOM   3577 C CB  . ARG B 1 158 ? 16.698  36.701  -32.864 1.00 20.21 ? 158  ARG B CB  1 ? 
ATOM   3578 C CG  . ARG B 1 158 ? 16.871  37.785  -33.921 1.00 25.09 ? 158  ARG B CG  1 ? 
ATOM   3579 C CD  . ARG B 1 158 ? 16.805  37.191  -35.322 1.00 26.87 ? 158  ARG B CD  1 ? 
ATOM   3580 N NE  . ARG B 1 158 ? 15.623  36.339  -35.482 1.00 29.96 ? 158  ARG B NE  1 ? 
ATOM   3581 C CZ  . ARG B 1 158 ? 15.604  35.114  -36.024 1.00 28.18 ? 158  ARG B CZ  1 ? 
ATOM   3582 N NH1 . ARG B 1 158 ? 16.694  34.574  -36.563 1.00 22.61 ? 158  ARG B NH1 1 ? 
ATOM   3583 N NH2 . ARG B 1 158 ? 14.460  34.457  -36.062 1.00 31.76 ? 158  ARG B NH2 1 ? 
ATOM   3584 N N   . ASP B 1 159 ? 13.693  36.607  -31.925 1.00 19.80 ? 159  ASP B N   1 ? 
ATOM   3585 C CA  . ASP B 1 159 ? 12.258  36.840  -32.238 1.00 23.62 ? 159  ASP B CA  1 ? 
ATOM   3586 C C   . ASP B 1 159 ? 11.601  37.659  -31.129 1.00 23.81 ? 159  ASP B C   1 ? 
ATOM   3587 O O   . ASP B 1 159 ? 10.647  38.401  -31.435 1.00 27.72 ? 159  ASP B O   1 ? 
ATOM   3588 C CB  . ASP B 1 159 ? 11.534  35.521  -32.470 1.00 25.75 ? 159  ASP B CB  1 ? 
ATOM   3589 C CG  . ASP B 1 159 ? 11.774  35.005  -33.866 1.00 31.63 ? 159  ASP B CG  1 ? 
ATOM   3590 O OD1 . ASP B 1 159 ? 12.316  35.785  -34.689 1.00 39.30 ? 159  ASP B OD1 1 ? 
ATOM   3591 O OD2 . ASP B 1 159 ? 11.431  33.847  -34.115 1.00 33.74 ? 159  ASP B OD2 1 ? 
ATOM   3592 N N   . ALA B 1 160 ? 12.119  37.570  -29.905 1.00 22.45 ? 160  ALA B N   1 ? 
ATOM   3593 C CA  . ALA B 1 160 ? 11.660  38.355  -28.742 1.00 22.43 ? 160  ALA B CA  1 ? 
ATOM   3594 C C   . ALA B 1 160 ? 12.383  39.720  -28.678 1.00 20.53 ? 160  ALA B C   1 ? 
ATOM   3595 O O   . ALA B 1 160 ? 12.101  40.468  -27.771 1.00 26.24 ? 160  ALA B O   1 ? 
ATOM   3596 C CB  . ALA B 1 160 ? 11.866  37.537  -27.493 1.00 21.62 ? 160  ALA B CB  1 ? 
ATOM   3597 N N   . GLY B 1 161 ? 13.289  40.028  -29.603 1.00 23.10 ? 161  GLY B N   1 ? 
ATOM   3598 C CA  . GLY B 1 161 ? 14.054  41.291  -29.654 1.00 23.62 ? 161  GLY B CA  1 ? 
ATOM   3599 C C   . GLY B 1 161 ? 15.149  41.357  -28.604 1.00 23.82 ? 161  GLY B C   1 ? 
ATOM   3600 O O   . GLY B 1 161 ? 15.682  42.460  -28.377 1.00 26.53 ? 161  GLY B O   1 ? 
ATOM   3601 N N   . VAL B 1 162 ? 15.501  40.233  -27.975 1.00 21.79 ? 162  VAL B N   1 ? 
ATOM   3602 C CA  . VAL B 1 162 ? 16.559  40.175  -26.925 1.00 20.82 ? 162  VAL B CA  1 ? 
ATOM   3603 C C   . VAL B 1 162 ? 17.919  40.201  -27.602 1.00 21.03 ? 162  VAL B C   1 ? 
ATOM   3604 O O   . VAL B 1 162 ? 18.159  39.442  -28.538 1.00 18.40 ? 162  VAL B O   1 ? 
ATOM   3605 C CB  . VAL B 1 162 ? 16.424  38.918  -26.050 1.00 19.96 ? 162  VAL B CB  1 ? 
ATOM   3606 C CG1 . VAL B 1 162 ? 17.499  38.865  -24.976 1.00 19.56 ? 162  VAL B CG1 1 ? 
ATOM   3607 C CG2 . VAL B 1 162 ? 15.045  38.794  -25.443 1.00 20.97 ? 162  VAL B CG2 1 ? 
ATOM   3608 N N   . PRO B 1 163 ? 18.873  41.043  -27.135 1.00 20.40 ? 163  PRO B N   1 ? 
ATOM   3609 C CA  . PRO B 1 163 ? 20.186  41.117  -27.750 1.00 21.65 ? 163  PRO B CA  1 ? 
ATOM   3610 C C   . PRO B 1 163 ? 20.897  39.765  -27.681 1.00 19.37 ? 163  PRO B C   1 ? 
ATOM   3611 O O   . PRO B 1 163 ? 20.976  39.168  -26.601 1.00 19.10 ? 163  PRO B O   1 ? 
ATOM   3612 C CB  . PRO B 1 163 ? 20.962  42.153  -26.920 1.00 22.06 ? 163  PRO B CB  1 ? 
ATOM   3613 C CG  . PRO B 1 163 ? 19.880  42.953  -26.241 1.00 24.71 ? 163  PRO B CG  1 ? 
ATOM   3614 C CD  . PRO B 1 163 ? 18.723  42.002  -26.027 1.00 22.60 ? 163  PRO B CD  1 ? 
ATOM   3615 N N   . LEU B 1 164 ? 21.402  39.318  -28.818 1.00 19.74 ? 164  LEU B N   1 ? 
ATOM   3616 C CA  . LEU B 1 164 ? 22.101  38.019  -28.920 1.00 18.72 ? 164  LEU B CA  1 ? 
ATOM   3617 C C   . LEU B 1 164 ? 23.534  38.181  -28.436 1.00 18.55 ? 164  LEU B C   1 ? 
ATOM   3618 O O   . LEU B 1 164 ? 24.084  39.281  -28.427 1.00 17.48 ? 164  LEU B O   1 ? 
ATOM   3619 C CB  . LEU B 1 164 ? 22.047  37.529  -30.366 1.00 19.47 ? 164  LEU B CB  1 ? 
ATOM   3620 C CG  . LEU B 1 164 ? 20.640  37.273  -30.891 1.00 18.64 ? 164  LEU B CG  1 ? 
ATOM   3621 C CD1 . LEU B 1 164 ? 20.692  36.607  -32.249 1.00 20.74 ? 164  LEU B CD1 1 ? 
ATOM   3622 C CD2 . LEU B 1 164 ? 19.832  36.432  -29.922 1.00 19.56 ? 164  LEU B CD2 1 ? 
ATOM   3623 N N   . PRO B 1 165 ? 24.178  37.074  -28.025 1.00 16.81 ? 165  PRO B N   1 ? 
ATOM   3624 C CA  . PRO B 1 165 ? 25.563  37.107  -27.571 1.00 16.25 ? 165  PRO B CA  1 ? 
ATOM   3625 C C   . PRO B 1 165 ? 26.552  37.301  -28.716 1.00 15.68 ? 165  PRO B C   1 ? 
ATOM   3626 O O   . PRO B 1 165 ? 26.154  37.321  -29.898 1.00 16.60 ? 165  PRO B O   1 ? 
ATOM   3627 C CB  . PRO B 1 165 ? 25.734  35.725  -26.925 1.00 16.79 ? 165  PRO B CB  1 ? 
ATOM   3628 C CG  . PRO B 1 165 ? 24.835  34.848  -27.737 1.00 16.41 ? 165  PRO B CG  1 ? 
ATOM   3629 C CD  . PRO B 1 165 ? 23.622  35.712  -27.964 1.00 16.36 ? 165  PRO B CD  1 ? 
ATOM   3630 N N   . ALA B 1 166 ? 27.828  37.417  -28.357 1.00 15.07 ? 166  ALA B N   1 ? 
ATOM   3631 C CA  . ALA B 1 166 ? 28.944  37.688  -29.282 1.00 15.33 ? 166  ALA B CA  1 ? 
ATOM   3632 C C   . ALA B 1 166 ? 29.144  36.530  -30.236 1.00 15.69 ? 166  ALA B C   1 ? 
ATOM   3633 O O   . ALA B 1 166 ? 29.671  36.742  -31.328 1.00 16.26 ? 166  ALA B O   1 ? 
ATOM   3634 C CB  . ALA B 1 166 ? 30.213  37.930  -28.519 1.00 15.86 ? 166  ALA B CB  1 ? 
ATOM   3635 N N   . ALA B 1 167 ? 28.842  35.310  -29.792 1.00 13.79 ? 167  ALA B N   1 ? 
ATOM   3636 C CA  . ALA B 1 167 ? 29.215  34.104  -30.540 1.00 13.27 ? 167  ALA B CA  1 ? 
ATOM   3637 C C   . ALA B 1 167 ? 28.442  32.933  -29.965 1.00 13.36 ? 167  ALA B C   1 ? 
ATOM   3638 O O   . ALA B 1 167 ? 27.864  33.029  -28.857 1.00 13.14 ? 167  ALA B O   1 ? 
ATOM   3639 C CB  . ALA B 1 167 ? 30.694  33.866  -30.518 1.00 14.48 ? 167  ALA B CB  1 ? 
ATOM   3640 N N   . ALA B 1 168 ? 28.400  31.866  -30.731 1.00 12.71 ? 168  ALA B N   1 ? 
ATOM   3641 C CA  . ALA B 1 168 ? 27.784  30.615  -30.247 1.00 13.14 ? 168  ALA B CA  1 ? 
ATOM   3642 C C   . ALA B 1 168 ? 28.602  29.455  -30.742 1.00 12.09 ? 168  ALA B C   1 ? 
ATOM   3643 O O   . ALA B 1 168 ? 29.331  29.571  -31.745 1.00 12.24 ? 168  ALA B O   1 ? 
ATOM   3644 C CB  . ALA B 1 168 ? 26.347  30.528  -30.645 1.00 14.24 ? 168  ALA B CB  1 ? 
ATOM   3645 N N   . VAL B 1 169 ? 28.498  28.338  -30.029 1.00 12.19 ? 169  VAL B N   1 ? 
ATOM   3646 C CA  . VAL B 1 169 ? 29.319  27.141  -30.299 1.00 12.44 ? 169  VAL B CA  1 ? 
ATOM   3647 C C   . VAL B 1 169 ? 28.414  25.917  -30.272 1.00 12.59 ? 169  VAL B C   1 ? 
ATOM   3648 O O   . VAL B 1 169 ? 27.676  25.760  -29.290 1.00 12.24 ? 169  VAL B O   1 ? 
ATOM   3649 C CB  . VAL B 1 169 ? 30.450  26.993  -29.272 1.00 12.93 ? 169  VAL B CB  1 ? 
ATOM   3650 C CG1 . VAL B 1 169 ? 31.210  25.723  -29.529 1.00 13.41 ? 169  VAL B CG1 1 ? 
ATOM   3651 C CG2 . VAL B 1 169 ? 31.384  28.202  -29.313 1.00 13.13 ? 169  VAL B CG2 1 ? 
ATOM   3652 N N   . CYS B 1 170 ? 28.506  25.082  -31.311 1.00 11.92 ? 170  CYS B N   1 ? 
ATOM   3653 C CA  . CYS B 1 170 ? 27.736  23.819  -31.435 1.00 13.38 ? 170  CYS B CA  1 ? 
ATOM   3654 C C   . CYS B 1 170 ? 28.717  22.675  -31.599 1.00 13.19 ? 170  CYS B C   1 ? 
ATOM   3655 O O   . CYS B 1 170 ? 29.525  22.703  -32.544 1.00 13.11 ? 170  CYS B O   1 ? 
ATOM   3656 C CB  . CYS B 1 170 ? 26.808  23.846  -32.642 1.00 14.02 ? 170  CYS B CB  1 ? 
ATOM   3657 S SG  . CYS B 1 170 ? 25.603  25.190  -32.575 1.00 17.46 ? 170  CYS B SG  1 ? 
ATOM   3658 N N   . LEU B 1 171 ? 28.689  21.700  -30.694 1.00 12.37 ? 171  LEU B N   1 ? 
ATOM   3659 C CA  . LEU B 1 171 ? 29.586  20.528  -30.741 1.00 12.68 ? 171  LEU B CA  1 ? 
ATOM   3660 C C   . LEU B 1 171 ? 28.746  19.324  -31.189 1.00 12.69 ? 171  LEU B C   1 ? 
ATOM   3661 O O   . LEU B 1 171 ? 27.864  18.898  -30.431 1.00 12.54 ? 171  LEU B O   1 ? 
ATOM   3662 C CB  . LEU B 1 171 ? 30.224  20.318  -29.362 1.00 13.68 ? 171  LEU B CB  1 ? 
ATOM   3663 C CG  . LEU B 1 171 ? 30.898  21.540  -28.731 1.00 13.85 ? 171  LEU B CG  1 ? 
ATOM   3664 C CD1 . LEU B 1 171 ? 31.585  21.123  -27.438 1.00 14.66 ? 171  LEU B CD1 1 ? 
ATOM   3665 C CD2 . LEU B 1 171 ? 31.894  22.214  -29.672 1.00 14.30 ? 171  LEU B CD2 1 ? 
ATOM   3666 N N   . SER B 1 172 ? 28.971  18.811  -32.395 1.00 12.48 ? 172  SER B N   1 ? 
ATOM   3667 C CA  . SER B 1 172 ? 28.195  17.672  -32.944 1.00 12.82 ? 172  SER B CA  1 ? 
ATOM   3668 C C   . SER B 1 172 ? 26.699  17.934  -32.802 1.00 12.84 ? 172  SER B C   1 ? 
ATOM   3669 O O   . SER B 1 172 ? 25.975  17.080  -32.281 1.00 12.27 ? 172  SER B O   1 ? 
ATOM   3670 C CB  . SER B 1 172 ? 28.528  16.363  -32.255 1.00 13.69 ? 172  SER B CB  1 ? 
ATOM   3671 O OG  . SER B 1 172 ? 29.933  16.123  -32.224 1.00 15.32 ? 172  SER B OG  1 ? 
ATOM   3672 N N   . PRO B 1 173 ? 26.164  19.088  -33.257 1.00 11.82 ? 173  PRO B N   1 ? 
ATOM   3673 C CA  . PRO B 1 173 ? 24.766  19.421  -33.020 1.00 12.09 ? 173  PRO B CA  1 ? 
ATOM   3674 C C   . PRO B 1 173 ? 23.786  18.434  -33.655 1.00 11.99 ? 173  PRO B C   1 ? 
ATOM   3675 O O   . PRO B 1 173 ? 24.032  17.934  -34.758 1.00 13.14 ? 173  PRO B O   1 ? 
ATOM   3676 C CB  . PRO B 1 173 ? 24.584  20.800  -33.670 1.00 11.87 ? 173  PRO B CB  1 ? 
ATOM   3677 C CG  . PRO B 1 173 ? 25.685  20.848  -34.703 1.00 12.46 ? 173  PRO B CG  1 ? 
ATOM   3678 C CD  . PRO B 1 173 ? 26.841  20.140  -34.027 1.00 12.52 ? 173  PRO B CD  1 ? 
ATOM   3679 N N   . TRP B 1 174 ? 22.681  18.229  -32.958 1.00 12.32 ? 174  TRP B N   1 ? 
ATOM   3680 C CA  . TRP B 1 174 ? 21.541  17.435  -33.456 1.00 12.88 ? 174  TRP B CA  1 ? 
ATOM   3681 C C   . TRP B 1 174 ? 20.418  18.410  -33.825 1.00 12.94 ? 174  TRP B C   1 ? 
ATOM   3682 O O   . TRP B 1 174 ? 19.815  19.000  -32.917 1.00 14.03 ? 174  TRP B O   1 ? 
ATOM   3683 C CB  . TRP B 1 174 ? 21.096  16.414  -32.416 1.00 13.09 ? 174  TRP B CB  1 ? 
ATOM   3684 C CG  . TRP B 1 174 ? 19.982  15.545  -32.902 1.00 12.93 ? 174  TRP B CG  1 ? 
ATOM   3685 C CD1 . TRP B 1 174 ? 19.768  15.095  -34.173 1.00 12.96 ? 174  TRP B CD1 1 ? 
ATOM   3686 C CD2 . TRP B 1 174 ? 18.943  14.978  -32.080 1.00 14.14 ? 174  TRP B CD2 1 ? 
ATOM   3687 N NE1 . TRP B 1 174 ? 18.658  14.288  -34.198 1.00 13.03 ? 174  TRP B NE1 1 ? 
ATOM   3688 C CE2 . TRP B 1 174 ? 18.148  14.188  -32.932 1.00 13.41 ? 174  TRP B CE2 1 ? 
ATOM   3689 C CE3 . TRP B 1 174 ? 18.627  15.050  -30.718 1.00 15.16 ? 174  TRP B CE3 1 ? 
ATOM   3690 C CZ2 . TRP B 1 174 ? 17.045  13.483  -32.453 1.00 13.78 ? 174  TRP B CZ2 1 ? 
ATOM   3691 C CZ3 . TRP B 1 174 ? 17.507  14.388  -30.255 1.00 14.42 ? 174  TRP B CZ3 1 ? 
ATOM   3692 C CH2 . TRP B 1 174 ? 16.742  13.593  -31.116 1.00 14.29 ? 174  TRP B CH2 1 ? 
ATOM   3693 N N   . VAL B 1 175 ? 20.187  18.601  -35.119 1.00 13.14 ? 175  VAL B N   1 ? 
ATOM   3694 C CA  . VAL B 1 175 ? 19.208  19.604  -35.630 1.00 13.48 ? 175  VAL B CA  1 ? 
ATOM   3695 C C   . VAL B 1 175 ? 18.168  18.985  -36.568 1.00 13.85 ? 175  VAL B C   1 ? 
ATOM   3696 O O   . VAL B 1 175 ? 17.224  19.722  -36.912 1.00 15.38 ? 175  VAL B O   1 ? 
ATOM   3697 C CB  . VAL B 1 175 ? 19.918  20.790  -36.305 1.00 14.41 ? 175  VAL B CB  1 ? 
ATOM   3698 C CG1 . VAL B 1 175 ? 20.712  21.587  -35.278 1.00 14.82 ? 175  VAL B CG1 1 ? 
ATOM   3699 C CG2 . VAL B 1 175 ? 20.773  20.356  -37.485 1.00 15.17 ? 175  VAL B CG2 1 ? 
ATOM   3700 N N   . ASP B 1 176 ? 18.310  17.710  -36.942 1.00 14.03 ? 176  ASP B N   1 ? 
ATOM   3701 C CA  . ASP B 1 176 ? 17.399  16.957  -37.842 1.00 14.64 ? 176  ASP B CA  1 ? 
ATOM   3702 C C   . ASP B 1 176 ? 16.790  15.817  -37.028 1.00 13.85 ? 176  ASP B C   1 ? 
ATOM   3703 O O   . ASP B 1 176 ? 17.477  14.808  -36.816 1.00 15.92 ? 176  ASP B O   1 ? 
ATOM   3704 C CB  . ASP B 1 176 ? 18.163  16.405  -39.053 1.00 14.42 ? 176  ASP B CB  1 ? 
ATOM   3705 C CG  . ASP B 1 176 ? 17.375  15.394  -39.872 1.00 15.64 ? 176  ASP B CG  1 ? 
ATOM   3706 O OD1 . ASP B 1 176 ? 16.128  15.308  -39.681 1.00 17.13 ? 176  ASP B OD1 1 ? 
ATOM   3707 O OD2 . ASP B 1 176 ? 18.022  14.700  -40.682 1.00 16.49 ? 176  ASP B OD2 1 ? 
ATOM   3708 N N   . LEU B 1 177 ? 15.565  15.984  -36.549 1.00 15.00 ? 177  LEU B N   1 ? 
ATOM   3709 C CA  . LEU B 1 177 ? 14.953  14.989  -35.622 1.00 14.86 ? 177  LEU B CA  1 ? 
ATOM   3710 C C   . LEU B 1 177 ? 14.363  13.812  -36.411 1.00 16.07 ? 177  LEU B C   1 ? 
ATOM   3711 O O   . LEU B 1 177 ? 13.813  12.920  -35.757 1.00 16.91 ? 177  LEU B O   1 ? 
ATOM   3712 C CB  . LEU B 1 177 ? 13.876  15.659  -34.771 1.00 16.07 ? 177  LEU B CB  1 ? 
ATOM   3713 C CG  . LEU B 1 177 ? 14.330  16.812  -33.889 1.00 18.63 ? 177  LEU B CG  1 ? 
ATOM   3714 C CD1 . LEU B 1 177 ? 13.223  17.256  -32.957 1.00 20.04 ? 177  LEU B CD1 1 ? 
ATOM   3715 C CD2 . LEU B 1 177 ? 15.541  16.446  -33.096 1.00 20.92 ? 177  LEU B CD2 1 ? 
ATOM   3716 N N   . GLU B 1 178 ? 14.481  13.807  -37.741 1.00 15.29 ? 178  GLU B N   1 ? 
ATOM   3717 C CA  . GLU B 1 178 ? 14.018  12.686  -38.602 1.00 16.63 ? 178  GLU B CA  1 ? 
ATOM   3718 C C   . GLU B 1 178 ? 15.178  11.766  -38.989 1.00 16.13 ? 178  GLU B C   1 ? 
ATOM   3719 O O   . GLU B 1 178 ? 14.906  10.670  -39.509 1.00 16.03 ? 178  GLU B O   1 ? 
ATOM   3720 C CB  . GLU B 1 178 ? 13.345  13.224  -39.854 1.00 18.29 ? 178  GLU B CB  1 ? 
ATOM   3721 C CG  . GLU B 1 178 ? 12.088  14.010  -39.565 1.00 20.75 ? 178  GLU B CG  1 ? 
ATOM   3722 C CD  . GLU B 1 178 ? 11.395  14.483  -40.831 1.00 23.89 ? 178  GLU B CD  1 ? 
ATOM   3723 O OE1 . GLU B 1 178 ? 12.021  15.221  -41.636 1.00 27.09 ? 178  GLU B OE1 1 ? 
ATOM   3724 O OE2 . GLU B 1 178 ? 10.238  14.081  -41.032 1.00 29.68 ? 178  GLU B OE2 1 ? 
ATOM   3725 N N   . GLY B 1 179 ? 16.438  12.178  -38.798 1.00 15.94 ? 179  GLY B N   1 ? 
ATOM   3726 C CA  . GLY B 1 179 ? 17.591  11.334  -39.140 1.00 16.27 ? 179  GLY B CA  1 ? 
ATOM   3727 C C   . GLY B 1 179 ? 17.643  11.007  -40.623 1.00 16.11 ? 179  GLY B C   1 ? 
ATOM   3728 O O   . GLY B 1 179 ? 17.797  9.804   -40.974 1.00 17.23 ? 179  GLY B O   1 ? 
ATOM   3729 N N   . ILE B 1 180 ? 17.522  12.014  -41.489 1.00 16.60 ? 180  ILE B N   1 ? 
ATOM   3730 C CA  . ILE B 1 180 ? 17.466  11.786  -42.963 1.00 17.99 ? 180  ILE B CA  1 ? 
ATOM   3731 C C   . ILE B 1 180 ? 18.735  12.304  -43.644 1.00 18.21 ? 180  ILE B C   1 ? 
ATOM   3732 O O   . ILE B 1 180 ? 18.773  12.301  -44.888 1.00 18.68 ? 180  ILE B O   1 ? 
ATOM   3733 C CB  . ILE B 1 180 ? 16.190  12.397  -43.568 1.00 19.31 ? 180  ILE B CB  1 ? 
ATOM   3734 C CG1 . ILE B 1 180 ? 16.124  13.910  -43.353 1.00 19.13 ? 180  ILE B CG1 1 ? 
ATOM   3735 C CG2 . ILE B 1 180 ? 14.964  11.690  -43.033 1.00 20.79 ? 180  ILE B CG2 1 ? 
ATOM   3736 C CD1 . ILE B 1 180 ? 15.028  14.601  -44.126 1.00 21.43 ? 180  ILE B CD1 1 ? 
ATOM   3737 N N   . GLY B 1 181 ? 19.749  12.717  -42.885 1.00 17.20 ? 181  GLY B N   1 ? 
ATOM   3738 C CA  . GLY B 1 181 ? 21.053  13.071  -43.471 1.00 16.84 ? 181  GLY B CA  1 ? 
ATOM   3739 C C   . GLY B 1 181 ? 21.705  11.856  -44.114 1.00 17.68 ? 181  GLY B C   1 ? 
ATOM   3740 O O   . GLY B 1 181 ? 21.532  10.738  -43.613 1.00 16.99 ? 181  GLY B O   1 ? 
ATOM   3741 N N   . GLU B 1 182 ? 22.493  12.063  -45.171 1.00 18.67 ? 182  GLU B N   1 ? 
ATOM   3742 C CA  . GLU B 1 182 ? 23.175  10.943  -45.863 1.00 21.93 ? 182  GLU B CA  1 ? 
ATOM   3743 C C   . GLU B 1 182 ? 24.084  10.199  -44.878 1.00 19.53 ? 182  GLU B C   1 ? 
ATOM   3744 O O   . GLU B 1 182 ? 24.105  8.981   -44.905 1.00 18.81 ? 182  GLU B O   1 ? 
ATOM   3745 C CB  . GLU B 1 182 ? 23.954  11.463  -47.070 1.00 25.37 ? 182  GLU B CB  1 ? 
ATOM   3746 C CG  . GLU B 1 182 ? 24.700  10.365  -47.796 1.00 31.04 ? 182  GLU B CG  1 ? 
ATOM   3747 C CD  . GLU B 1 182 ? 25.417  10.811  -49.055 1.00 36.01 ? 182  GLU B CD  1 ? 
ATOM   3748 O OE1 . GLU B 1 182 ? 25.755  12.016  -49.149 1.00 41.61 ? 182  GLU B OE1 1 ? 
ATOM   3749 O OE2 . GLU B 1 182 ? 25.643  9.951   -49.940 1.00 41.71 ? 182  GLU B OE2 1 ? 
ATOM   3750 N N   . SER B 1 183 ? 24.806  10.903  -44.000 1.00 18.38 ? 183  SER B N   1 ? 
ATOM   3751 C CA  . SER B 1 183 ? 25.759  10.285  -43.047 1.00 16.57 ? 183  SER B CA  1 ? 
ATOM   3752 C C   . SER B 1 183 ? 25.044  9.360   -42.058 1.00 15.04 ? 183  SER B C   1 ? 
ATOM   3753 O O   . SER B 1 183 ? 25.706  8.499   -41.467 1.00 16.57 ? 183  SER B O   1 ? 
ATOM   3754 C CB  . SER B 1 183 ? 26.597  11.319  -42.332 1.00 16.72 ? 183  SER B CB  1 ? 
ATOM   3755 O OG  . SER B 1 183 ? 25.772  12.236  -41.651 1.00 16.60 ? 183  SER B OG  1 ? 
ATOM   3756 N N   . MET B 1 184 ? 23.738  9.514   -41.843 1.00 16.45 ? 184  MET B N   1 ? 
ATOM   3757 C CA  . MET B 1 184 ? 22.992  8.631   -40.913 1.00 19.14 ? 184  MET B CA  1 ? 
ATOM   3758 C C   . MET B 1 184 ? 23.042  7.197   -41.480 1.00 18.03 ? 184  MET B C   1 ? 
ATOM   3759 O O   . MET B 1 184 ? 23.013  6.249   -40.702 1.00 18.88 ? 184  MET B O   1 ? 
ATOM   3760 C CB  . MET B 1 184 ? 21.550  9.119   -40.752 1.00 18.91 ? 184  MET B CB  1 ? 
ATOM   3761 C CG  . MET B 1 184 ? 20.785  8.473   -39.623 1.00 20.46 ? 184  MET B CG  1 ? 
ATOM   3762 S SD  . MET B 1 184 ? 21.577  8.594   -37.991 1.00 19.69 ? 184  MET B SD  1 ? 
ATOM   3763 C CE  . MET B 1 184 ? 21.809  10.362  -37.783 1.00 17.98 ? 184  MET B CE  1 ? 
ATOM   3764 N N   . THR B 1 185 ? 23.187  7.082   -42.801 1.00 20.01 ? 185  THR B N   1 ? 
ATOM   3765 C CA  . THR B 1 185 ? 23.493  5.821   -43.534 1.00 21.94 ? 185  THR B CA  1 ? 
ATOM   3766 C C   . THR B 1 185 ? 25.009  5.664   -43.751 1.00 22.40 ? 185  THR B C   1 ? 
ATOM   3767 O O   . THR B 1 185 ? 25.534  4.608   -43.363 1.00 28.03 ? 185  THR B O   1 ? 
ATOM   3768 C CB  . THR B 1 185 ? 22.723  5.775   -44.857 1.00 24.25 ? 185  THR B CB  1 ? 
ATOM   3769 O OG1 . THR B 1 185 ? 21.338  5.918   -44.531 1.00 23.92 ? 185  THR B OG1 1 ? 
ATOM   3770 C CG2 . THR B 1 185 ? 22.961  4.490   -45.624 1.00 26.93 ? 185  THR B CG2 1 ? 
ATOM   3771 N N   . THR B 1 186 ? 25.688  6.617   -44.392 1.00 24.37 ? 186  THR B N   1 ? 
ATOM   3772 C CA  . THR B 1 186 ? 27.064  6.423   -44.946 1.00 24.55 ? 186  THR B CA  1 ? 
ATOM   3773 C C   . THR B 1 186 ? 28.141  6.445   -43.858 1.00 25.54 ? 186  THR B C   1 ? 
ATOM   3774 O O   . THR B 1 186 ? 29.234  5.938   -44.145 1.00 25.14 ? 186  THR B O   1 ? 
ATOM   3775 C CB  . THR B 1 186 ? 27.431  7.434   -46.034 1.00 26.94 ? 186  THR B CB  1 ? 
ATOM   3776 O OG1 . THR B 1 186 ? 27.452  8.749   -45.479 1.00 28.69 ? 186  THR B OG1 1 ? 
ATOM   3777 C CG2 . THR B 1 186 ? 26.494  7.372   -47.219 1.00 27.66 ? 186  THR B CG2 1 ? 
ATOM   3778 N N   . LYS B 1 187 ? 27.877  6.990   -42.662 1.00 22.96 ? 187  LYS B N   1 ? 
ATOM   3779 C CA  . LYS B 1 187 ? 28.864  6.966   -41.547 1.00 23.52 ? 187  LYS B CA  1 ? 
ATOM   3780 C C   . LYS B 1 187 ? 28.411  5.996   -40.457 1.00 21.18 ? 187  LYS B C   1 ? 
ATOM   3781 O O   . LYS B 1 187 ? 29.044  5.968   -39.406 1.00 22.34 ? 187  LYS B O   1 ? 
ATOM   3782 C CB  . LYS B 1 187 ? 29.062  8.358   -40.936 1.00 23.77 ? 187  LYS B CB  1 ? 
ATOM   3783 C CG  . LYS B 1 187 ? 29.633  9.396   -41.890 1.00 25.93 ? 187  LYS B CG  1 ? 
ATOM   3784 C CD  . LYS B 1 187 ? 31.053  9.079   -42.308 1.00 27.93 ? 187  LYS B CD  1 ? 
ATOM   3785 C CE  . LYS B 1 187 ? 31.612  10.122  -43.254 1.00 32.39 ? 187  LYS B CE  1 ? 
ATOM   3786 N NZ  . LYS B 1 187 ? 33.093  10.142  -43.243 1.00 33.15 ? 187  LYS B NZ  1 ? 
ATOM   3787 N N   . ALA B 1 188 ? 27.341  5.249   -40.674 1.00 22.02 ? 188  ALA B N   1 ? 
ATOM   3788 C CA  . ALA B 1 188 ? 26.793  4.333   -39.642 1.00 20.75 ? 188  ALA B CA  1 ? 
ATOM   3789 C C   . ALA B 1 188 ? 27.833  3.290   -39.219 1.00 24.26 ? 188  ALA B C   1 ? 
ATOM   3790 O O   . ALA B 1 188 ? 27.793  2.894   -38.037 1.00 24.75 ? 188  ALA B O   1 ? 
ATOM   3791 C CB  . ALA B 1 188 ? 25.559  3.665   -40.152 1.00 23.28 ? 188  ALA B CB  1 ? 
ATOM   3792 N N   . ALA B 1 189 ? 28.694  2.822   -40.137 1.00 24.04 ? 189  ALA B N   1 ? 
ATOM   3793 C CA  . ALA B 1 189 ? 29.687  1.758   -39.846 1.00 24.02 ? 189  ALA B CA  1 ? 
ATOM   3794 C C   . ALA B 1 189 ? 30.908  2.333   -39.111 1.00 24.30 ? 189  ALA B C   1 ? 
ATOM   3795 O O   . ALA B 1 189 ? 31.782  1.519   -38.744 1.00 25.36 ? 189  ALA B O   1 ? 
ATOM   3796 C CB  . ALA B 1 189 ? 30.090  1.013   -41.119 1.00 24.79 ? 189  ALA B CB  1 ? 
ATOM   3797 N N   . VAL B 1 190 ? 31.040  3.651   -38.909 1.00 22.71 ? 190  VAL B N   1 ? 
ATOM   3798 C CA  . VAL B 1 190 ? 32.190  4.227   -38.152 1.00 22.29 ? 190  VAL B CA  1 ? 
ATOM   3799 C C   . VAL B 1 190 ? 31.727  4.984   -36.903 1.00 23.01 ? 190  VAL B C   1 ? 
ATOM   3800 O O   . VAL B 1 190 ? 32.618  5.434   -36.163 1.00 25.91 ? 190  VAL B O   1 ? 
ATOM   3801 C CB  . VAL B 1 190 ? 33.087  5.093   -39.054 1.00 23.58 ? 190  VAL B CB  1 ? 
ATOM   3802 C CG1 . VAL B 1 190 ? 33.709  4.239   -40.162 1.00 25.90 ? 190  VAL B CG1 1 ? 
ATOM   3803 C CG2 . VAL B 1 190 ? 32.332  6.281   -39.643 1.00 22.56 ? 190  VAL B CG2 1 ? 
ATOM   3804 N N   . ASP B 1 191 ? 30.428  5.083   -36.615 1.00 22.06 ? 191  ASP B N   1 ? 
ATOM   3805 C CA  . ASP B 1 191 ? 29.933  5.850   -35.427 1.00 21.92 ? 191  ASP B CA  1 ? 
ATOM   3806 C C   . ASP B 1 191 ? 29.655  4.891   -34.280 1.00 22.24 ? 191  ASP B C   1 ? 
ATOM   3807 O O   . ASP B 1 191 ? 28.756  4.056   -34.378 1.00 24.27 ? 191  ASP B O   1 ? 
ATOM   3808 C CB  . ASP B 1 191 ? 28.645  6.625   -35.719 1.00 20.77 ? 191  ASP B CB  1 ? 
ATOM   3809 C CG  . ASP B 1 191 ? 28.242  7.626   -34.632 1.00 19.04 ? 191  ASP B CG  1 ? 
ATOM   3810 O OD1 . ASP B 1 191 ? 28.445  7.352   -33.428 1.00 18.83 ? 191  ASP B OD1 1 ? 
ATOM   3811 O OD2 . ASP B 1 191 ? 27.707  8.681   -35.003 1.00 18.08 ? 191  ASP B OD2 1 ? 
ATOM   3812 N N   . PRO B 1 192 ? 30.410  4.948   -33.157 1.00 21.98 ? 192  PRO B N   1 ? 
ATOM   3813 C CA  . PRO B 1 192 ? 30.176  4.024   -32.050 1.00 22.68 ? 192  PRO B CA  1 ? 
ATOM   3814 C C   . PRO B 1 192 ? 29.077  4.364   -31.035 1.00 23.73 ? 192  PRO B C   1 ? 
ATOM   3815 O O   . PRO B 1 192 ? 28.871  3.589   -30.125 1.00 27.22 ? 192  PRO B O   1 ? 
ATOM   3816 C CB  . PRO B 1 192 ? 31.518  4.115   -31.300 1.00 23.02 ? 192  PRO B CB  1 ? 
ATOM   3817 C CG  . PRO B 1 192 ? 31.880  5.563   -31.442 1.00 23.27 ? 192  PRO B CG  1 ? 
ATOM   3818 C CD  . PRO B 1 192 ? 31.529  5.863   -32.890 1.00 22.47 ? 192  PRO B CD  1 ? 
ATOM   3819 N N   A MET B 1 193 ? 28.416  5.510   -31.193 0.50 23.08 ? 193  MET B N   1 ? 
ATOM   3820 N N   B MET B 1 193 ? 28.405  5.518   -31.156 0.50 23.68 ? 193  MET B N   1 ? 
ATOM   3821 C CA  A MET B 1 193 ? 27.544  6.098   -30.142 0.50 22.36 ? 193  MET B CA  1 ? 
ATOM   3822 C CA  B MET B 1 193 ? 27.492  6.005   -30.082 0.50 23.25 ? 193  MET B CA  1 ? 
ATOM   3823 C C   A MET B 1 193 ? 26.136  6.392   -30.675 0.50 21.38 ? 193  MET B C   1 ? 
ATOM   3824 C C   B MET B 1 193 ? 26.157  6.578   -30.587 0.50 21.13 ? 193  MET B C   1 ? 
ATOM   3825 O O   A MET B 1 193 ? 25.155  6.093   -29.970 0.50 23.64 ? 193  MET B O   1 ? 
ATOM   3826 O O   B MET B 1 193 ? 25.264  6.709   -29.736 0.50 19.24 ? 193  MET B O   1 ? 
ATOM   3827 C CB  A MET B 1 193 ? 28.128  7.413   -29.630 0.50 24.66 ? 193  MET B CB  1 ? 
ATOM   3828 C CB  B MET B 1 193 ? 28.156  7.088   -29.233 0.50 27.73 ? 193  MET B CB  1 ? 
ATOM   3829 C CG  A MET B 1 193 ? 27.589  7.762   -28.288 0.50 27.18 ? 193  MET B CG  1 ? 
ATOM   3830 C CG  B MET B 1 193 ? 27.504  7.219   -27.876 0.50 31.01 ? 193  MET B CG  1 ? 
ATOM   3831 S SD  A MET B 1 193 ? 28.180  9.340   -27.688 0.50 30.24 ? 193  MET B SD  1 ? 
ATOM   3832 S SD  B MET B 1 193 ? 28.697  7.643   -26.604 0.50 36.52 ? 193  MET B SD  1 ? 
ATOM   3833 C CE  A MET B 1 193 ? 29.958  9.117   -27.714 0.50 25.41 ? 193  MET B CE  1 ? 
ATOM   3834 C CE  B MET B 1 193 ? 29.618  8.929   -27.450 0.50 30.50 ? 193  MET B CE  1 ? 
ATOM   3835 N N   . VAL B 1 194 ? 26.049  7.022   -31.843 1.00 18.45 ? 194  VAL B N   1 ? 
ATOM   3836 C CA  . VAL B 1 194 ? 24.780  7.578   -32.376 1.00 18.41 ? 194  VAL B CA  1 ? 
ATOM   3837 C C   . VAL B 1 194 ? 24.366  6.760   -33.588 1.00 17.25 ? 194  VAL B C   1 ? 
ATOM   3838 O O   . VAL B 1 194 ? 25.161  6.613   -34.525 1.00 18.42 ? 194  VAL B O   1 ? 
ATOM   3839 C CB  . VAL B 1 194 ? 24.897  9.062   -32.739 1.00 16.97 ? 194  VAL B CB  1 ? 
ATOM   3840 C CG1 . VAL B 1 194 ? 23.561  9.587   -33.263 1.00 17.14 ? 194  VAL B CG1 1 ? 
ATOM   3841 C CG2 . VAL B 1 194 ? 25.346  9.865   -31.535 1.00 18.64 ? 194  VAL B CG2 1 ? 
ATOM   3842 N N   . GLN B 1 195 ? 23.134  6.251   -33.544 1.00 18.29 ? 195  GLN B N   1 ? 
ATOM   3843 C CA  . GLN B 1 195 ? 22.501  5.604   -34.713 1.00 18.39 ? 195  GLN B CA  1 ? 
ATOM   3844 C C   . GLN B 1 195 ? 21.048  6.083   -34.791 1.00 17.11 ? 195  GLN B C   1 ? 
ATOM   3845 O O   . GLN B 1 195 ? 20.498  6.667   -33.800 1.00 16.90 ? 195  GLN B O   1 ? 
ATOM   3846 C CB  . GLN B 1 195 ? 22.613  4.081   -34.628 1.00 21.28 ? 195  GLN B CB  1 ? 
ATOM   3847 C CG  . GLN B 1 195 ? 24.050  3.560   -34.585 1.00 22.95 ? 195  GLN B CG  1 ? 
ATOM   3848 C CD  . GLN B 1 195 ? 24.810  3.678   -35.891 1.00 25.62 ? 195  GLN B CD  1 ? 
ATOM   3849 O OE1 . GLN B 1 195 ? 24.238  3.656   -36.984 1.00 27.09 ? 195  GLN B OE1 1 ? 
ATOM   3850 N NE2 . GLN B 1 195 ? 26.128  3.796   -35.804 1.00 27.31 ? 195  GLN B NE2 1 ? 
ATOM   3851 N N   . ARG B 1 196 ? 20.420  5.816   -35.922 1.00 16.11 ? 196  ARG B N   1 ? 
ATOM   3852 C CA  . ARG B 1 196 ? 19.107  6.408   -36.244 1.00 16.94 ? 196  ARG B CA  1 ? 
ATOM   3853 C C   . ARG B 1 196 ? 18.050  5.968   -35.224 1.00 16.91 ? 196  ARG B C   1 ? 
ATOM   3854 O O   . ARG B 1 196 ? 17.236  6.810   -34.816 1.00 16.60 ? 196  ARG B O   1 ? 
ATOM   3855 C CB  . ARG B 1 196 ? 18.687  6.011   -37.660 1.00 17.55 ? 196  ARG B CB  1 ? 
ATOM   3856 C CG  . ARG B 1 196 ? 17.541  6.859   -38.177 1.00 19.19 ? 196  ARG B CG  1 ? 
ATOM   3857 C CD  . ARG B 1 196 ? 17.286  6.641   -39.648 1.00 20.82 ? 196  ARG B CD  1 ? 
ATOM   3858 N NE  . ARG B 1 196 ? 16.280  7.600   -40.083 1.00 23.71 ? 196  ARG B NE  1 ? 
ATOM   3859 C CZ  . ARG B 1 196 ? 15.050  7.317   -40.498 1.00 26.83 ? 196  ARG B CZ  1 ? 
ATOM   3860 N NH1 . ARG B 1 196 ? 14.610  6.065   -40.536 1.00 30.01 ? 196  ARG B NH1 1 ? 
ATOM   3861 N NH2 . ARG B 1 196 ? 14.263  8.300   -40.898 1.00 27.65 ? 196  ARG B NH2 1 ? 
ATOM   3862 N N   . GLU B 1 197 ? 18.003  4.686   -34.847 1.00 18.89 ? 197  GLU B N   1 ? 
ATOM   3863 C CA  . GLU B 1 197 ? 16.841  4.199   -34.064 1.00 21.32 ? 197  GLU B CA  1 ? 
ATOM   3864 C C   . GLU B 1 197 ? 16.788  4.889   -32.704 1.00 19.89 ? 197  GLU B C   1 ? 
ATOM   3865 O O   . GLU B 1 197 ? 15.736  5.400   -32.337 1.00 16.78 ? 197  GLU B O   1 ? 
ATOM   3866 C CB  . GLU B 1 197 ? 16.799  2.675   -34.001 1.00 25.96 ? 197  GLU B CB  1 ? 
ATOM   3867 C CG  . GLU B 1 197 ? 16.206  2.058   -35.266 1.00 32.30 ? 197  GLU B CG  1 ? 
ATOM   3868 C CD  . GLU B 1 197 ? 15.062  2.805   -35.949 1.00 38.78 ? 197  GLU B CD  1 ? 
ATOM   3869 O OE1 . GLU B 1 197 ? 13.994  3.012   -35.308 1.00 44.09 ? 197  GLU B OE1 1 ? 
ATOM   3870 O OE2 . GLU B 1 197 ? 15.229  3.173   -37.136 1.00 45.69 ? 197  GLU B OE2 1 ? 
ATOM   3871 N N   . PRO B 1 198 ? 17.887  4.972   -31.923 1.00 19.74 ? 198  PRO B N   1 ? 
ATOM   3872 C CA  . PRO B 1 198 ? 17.837  5.702   -30.658 1.00 19.59 ? 198  PRO B CA  1 ? 
ATOM   3873 C C   . PRO B 1 198 ? 17.539  7.196   -30.833 1.00 18.21 ? 198  PRO B C   1 ? 
ATOM   3874 O O   . PRO B 1 198 ? 16.828  7.754   -30.027 1.00 18.55 ? 198  PRO B O   1 ? 
ATOM   3875 C CB  . PRO B 1 198 ? 19.232  5.491   -30.034 1.00 21.16 ? 198  PRO B CB  1 ? 
ATOM   3876 C CG  . PRO B 1 198 ? 19.791  4.283   -30.753 1.00 23.18 ? 198  PRO B CG  1 ? 
ATOM   3877 C CD  . PRO B 1 198 ? 19.164  4.272   -32.131 1.00 22.78 ? 198  PRO B CD  1 ? 
ATOM   3878 N N   . LEU B 1 199 ? 18.081  7.835   -31.870 1.00 17.90 ? 199  LEU B N   1 ? 
ATOM   3879 C CA  . LEU B 1 199 ? 17.722  9.252   -32.152 1.00 18.48 ? 199  LEU B CA  1 ? 
ATOM   3880 C C   . LEU B 1 199 ? 16.215  9.394   -32.347 1.00 17.84 ? 199  LEU B C   1 ? 
ATOM   3881 O O   . LEU B 1 199 ? 15.627  10.343  -31.815 1.00 16.99 ? 199  LEU B O   1 ? 
ATOM   3882 C CB  . LEU B 1 199 ? 18.447  9.744   -33.401 1.00 19.97 ? 199  LEU B CB  1 ? 
ATOM   3883 C CG  . LEU B 1 199 ? 19.905  10.121  -33.221 1.00 22.67 ? 199  LEU B CG  1 ? 
ATOM   3884 C CD1 . LEU B 1 199 ? 20.407  10.798  -34.483 1.00 22.81 ? 199  LEU B CD1 1 ? 
ATOM   3885 C CD2 . LEU B 1 199 ? 20.135  11.023  -32.011 1.00 22.40 ? 199  LEU B CD2 1 ? 
ATOM   3886 N N   . LEU B 1 200 ? 15.595  8.515   -33.131 1.00 17.15 ? 200  LEU B N   1 ? 
ATOM   3887 C CA  . LEU B 1 200 ? 14.138  8.634   -33.389 1.00 16.54 ? 200  LEU B CA  1 ? 
ATOM   3888 C C   . LEU B 1 200 ? 13.367  8.409   -32.077 1.00 15.87 ? 200  LEU B C   1 ? 
ATOM   3889 O O   . LEU B 1 200 ? 12.354  9.073   -31.863 1.00 15.37 ? 200  LEU B O   1 ? 
ATOM   3890 C CB  . LEU B 1 200 ? 13.729  7.645   -34.482 1.00 18.10 ? 200  LEU B CB  1 ? 
ATOM   3891 C CG  . LEU B 1 200 ? 14.208  7.991   -35.891 1.00 19.17 ? 200  LEU B CG  1 ? 
ATOM   3892 C CD1 . LEU B 1 200 ? 13.810  6.902   -36.878 1.00 21.56 ? 200  LEU B CD1 1 ? 
ATOM   3893 C CD2 . LEU B 1 200 ? 13.659  9.326   -36.349 1.00 21.20 ? 200  LEU B CD2 1 ? 
ATOM   3894 N N   A ARG B 1 201 ? 13.843  7.493   -31.236 0.50 16.09 ? 201  ARG B N   1 ? 
ATOM   3895 N N   B ARG B 1 201 ? 13.814  7.477   -31.230 0.50 15.87 ? 201  ARG B N   1 ? 
ATOM   3896 C CA  A ARG B 1 201 ? 13.241  7.199   -29.911 0.50 17.56 ? 201  ARG B CA  1 ? 
ATOM   3897 C CA  B ARG B 1 201 ? 13.189  7.207   -29.904 0.50 17.26 ? 201  ARG B CA  1 ? 
ATOM   3898 C C   A ARG B 1 201 ? 13.241  8.467   -29.055 0.50 16.89 ? 201  ARG B C   1 ? 
ATOM   3899 C C   B ARG B 1 201 ? 13.224  8.494   -29.069 0.50 16.65 ? 201  ARG B C   1 ? 
ATOM   3900 O O   A ARG B 1 201 ? 12.213  8.793   -28.475 0.50 17.82 ? 201  ARG B O   1 ? 
ATOM   3901 O O   B ARG B 1 201 ? 12.188  8.885   -28.543 0.50 17.51 ? 201  ARG B O   1 ? 
ATOM   3902 C CB  A ARG B 1 201 ? 14.028  6.075   -29.236 0.50 19.10 ? 201  ARG B CB  1 ? 
ATOM   3903 C CB  B ARG B 1 201 ? 13.888  6.017   -29.235 0.50 18.45 ? 201  ARG B CB  1 ? 
ATOM   3904 C CG  A ARG B 1 201 ? 13.213  5.246   -28.255 0.50 20.99 ? 201  ARG B CG  1 ? 
ATOM   3905 C CG  B ARG B 1 201 ? 13.550  5.781   -27.770 0.50 20.44 ? 201  ARG B CG  1 ? 
ATOM   3906 C CD  A ARG B 1 201 ? 13.492  3.763   -28.478 0.50 22.42 ? 201  ARG B CD  1 ? 
ATOM   3907 C CD  B ARG B 1 201 ? 14.001  4.395   -27.311 0.50 21.90 ? 201  ARG B CD  1 ? 
ATOM   3908 N NE  A ARG B 1 201 ? 14.914  3.426   -28.512 0.50 22.66 ? 201  ARG B NE  1 ? 
ATOM   3909 N NE  B ARG B 1 201 ? 15.120  4.408   -26.376 0.50 24.30 ? 201  ARG B NE  1 ? 
ATOM   3910 C CZ  A ARG B 1 201 ? 15.524  2.766   -29.501 0.50 24.21 ? 201  ARG B CZ  1 ? 
ATOM   3911 C CZ  B ARG B 1 201 ? 16.356  3.993   -26.647 0.50 24.88 ? 201  ARG B CZ  1 ? 
ATOM   3912 N NH1 A ARG B 1 201 ? 14.844  2.373   -30.565 0.50 23.62 ? 201  ARG B NH1 1 ? 
ATOM   3913 N NH1 B ARG B 1 201 ? 16.670  3.506   -27.836 0.50 25.99 ? 201  ARG B NH1 1 ? 
ATOM   3914 N NH2 A ARG B 1 201 ? 16.815  2.500   -29.421 0.50 26.46 ? 201  ARG B NH2 1 ? 
ATOM   3915 N NH2 B ARG B 1 201 ? 17.279  4.047   -25.707 0.50 26.44 ? 201  ARG B NH2 1 ? 
ATOM   3916 N N   . MET B 1 202 ? 14.372  9.163   -28.999 1.00 15.98 ? 202  MET B N   1 ? 
ATOM   3917 C CA  . MET B 1 202 ? 14.501  10.394  -28.185 1.00 16.10 ? 202  MET B CA  1 ? 
ATOM   3918 C C   . MET B 1 202 ? 13.703  11.529  -28.825 1.00 14.57 ? 202  MET B C   1 ? 
ATOM   3919 O O   . MET B 1 202 ? 13.009  12.242  -28.084 1.00 15.28 ? 202  MET B O   1 ? 
ATOM   3920 C CB  . MET B 1 202 ? 15.969  10.748  -28.021 1.00 16.90 ? 202  MET B CB  1 ? 
ATOM   3921 C CG  . MET B 1 202 ? 16.669  9.733   -27.133 1.00 19.02 ? 202  MET B CG  1 ? 
ATOM   3922 S SD  . MET B 1 202 ? 18.399  10.089  -26.777 1.00 22.25 ? 202  MET B SD  1 ? 
ATOM   3923 C CE  . MET B 1 202 ? 19.041  10.225  -28.434 1.00 24.56 ? 202  MET B CE  1 ? 
ATOM   3924 N N   . ALA B 1 203 ? 13.725  11.659  -30.156 1.00 14.37 ? 203  ALA B N   1 ? 
ATOM   3925 C CA  . ALA B 1 203 ? 12.919  12.680  -30.860 1.00 14.59 ? 203  ALA B CA  1 ? 
ATOM   3926 C C   . ALA B 1 203 ? 11.442  12.498  -30.503 1.00 14.69 ? 203  ALA B C   1 ? 
ATOM   3927 O O   . ALA B 1 203 ? 10.739  13.475  -30.246 1.00 15.70 ? 203  ALA B O   1 ? 
ATOM   3928 C CB  . ALA B 1 203 ? 13.137  12.603  -32.340 1.00 14.22 ? 203  ALA B CB  1 ? 
ATOM   3929 N N   . SER B 1 204 ? 10.970  11.250  -30.476 1.00 15.63 ? 204  SER B N   1 ? 
ATOM   3930 C CA  . SER B 1 204 ? 9.544   10.964  -30.189 1.00 17.23 ? 204  SER B CA  1 ? 
ATOM   3931 C C   . SER B 1 204 ? 9.184   11.465  -28.782 1.00 17.54 ? 204  SER B C   1 ? 
ATOM   3932 O O   . SER B 1 204 ? 8.090   12.048  -28.601 1.00 19.35 ? 204  SER B O   1 ? 
ATOM   3933 C CB  . SER B 1 204 ? 9.272   9.502   -30.329 1.00 19.80 ? 204  SER B CB  1 ? 
ATOM   3934 O OG  . SER B 1 204 ? 7.917   9.258   -30.006 1.00 23.18 ? 204  SER B OG  1 ? 
ATOM   3935 N N   . MET B 1 205 ? 10.077  11.237  -27.821 1.00 16.59 ? 205  MET B N   1 ? 
ATOM   3936 C CA  . MET B 1 205 ? 9.851   11.642  -26.413 1.00 17.69 ? 205  MET B CA  1 ? 
ATOM   3937 C C   . MET B 1 205 ? 9.837   13.171  -26.301 1.00 17.03 ? 205  MET B C   1 ? 
ATOM   3938 O O   . MET B 1 205 ? 8.976   13.716  -25.616 1.00 17.04 ? 205  MET B O   1 ? 
ATOM   3939 C CB  . MET B 1 205 ? 10.913  11.029  -25.505 1.00 20.29 ? 205  MET B CB  1 ? 
ATOM   3940 C CG  . MET B 1 205 ? 10.704  9.553   -25.393 1.00 22.00 ? 205  MET B CG  1 ? 
ATOM   3941 S SD  . MET B 1 205 ? 11.687  8.896   -24.078 1.00 27.10 ? 205  MET B SD  1 ? 
ATOM   3942 C CE  . MET B 1 205 ? 13.201  8.509   -24.928 1.00 26.69 ? 205  MET B CE  1 ? 
ATOM   3943 N N   . TYR B 1 206 ? 10.739  13.843  -27.005 1.00 15.65 ? 206  TYR B N   1 ? 
ATOM   3944 C CA  . TYR B 1 206 ? 10.861  15.321  -26.963 1.00 15.76 ? 206  TYR B CA  1 ? 
ATOM   3945 C C   . TYR B 1 206 ? 9.664   15.970  -27.668 1.00 16.11 ? 206  TYR B C   1 ? 
ATOM   3946 O O   . TYR B 1 206 ? 9.132   16.980  -27.181 1.00 15.63 ? 206  TYR B O   1 ? 
ATOM   3947 C CB  . TYR B 1 206 ? 12.185  15.728  -27.610 1.00 14.66 ? 206  TYR B CB  1 ? 
ATOM   3948 C CG  . TYR B 1 206 ? 12.500  17.200  -27.553 1.00 14.44 ? 206  TYR B CG  1 ? 
ATOM   3949 C CD1 . TYR B 1 206 ? 12.422  17.900  -26.367 1.00 14.27 ? 206  TYR B CD1 1 ? 
ATOM   3950 C CD2 . TYR B 1 206 ? 12.881  17.887  -28.696 1.00 14.16 ? 206  TYR B CD2 1 ? 
ATOM   3951 C CE1 . TYR B 1 206 ? 12.744  19.245  -26.299 1.00 14.42 ? 206  TYR B CE1 1 ? 
ATOM   3952 C CE2 . TYR B 1 206 ? 13.209  19.235  -28.645 1.00 14.31 ? 206  TYR B CE2 1 ? 
ATOM   3953 C CZ  . TYR B 1 206 ? 13.128  19.916  -27.444 1.00 14.87 ? 206  TYR B CZ  1 ? 
ATOM   3954 O OH  . TYR B 1 206 ? 13.416  21.260  -27.351 1.00 16.20 ? 206  TYR B OH  1 ? 
ATOM   3955 N N   . LEU B 1 207 ? 9.234   15.406  -28.802 1.00 15.98 ? 207  LEU B N   1 ? 
ATOM   3956 C CA  . LEU B 1 207 ? 8.167   16.017  -29.627 1.00 16.33 ? 207  LEU B CA  1 ? 
ATOM   3957 C C   . LEU B 1 207 ? 6.778   15.733  -29.050 1.00 17.87 ? 207  LEU B C   1 ? 
ATOM   3958 O O   . LEU B 1 207 ? 5.928   16.597  -29.187 1.00 19.21 ? 207  LEU B O   1 ? 
ATOM   3959 C CB  . LEU B 1 207 ? 8.281   15.505  -31.059 1.00 16.93 ? 207  LEU B CB  1 ? 
ATOM   3960 C CG  . LEU B 1 207 ? 9.487   16.046  -31.828 1.00 17.49 ? 207  LEU B CG  1 ? 
ATOM   3961 C CD1 . LEU B 1 207 ? 9.692   15.264  -33.107 1.00 17.82 ? 207  LEU B CD1 1 ? 
ATOM   3962 C CD2 . LEU B 1 207 ? 9.355   17.538  -32.105 1.00 18.21 ? 207  LEU B CD2 1 ? 
ATOM   3963 N N   . ALA B 1 208 ? 6.561   14.579  -28.437 1.00 19.34 ? 208  ALA B N   1 ? 
ATOM   3964 C CA  . ALA B 1 208 ? 5.241   14.231  -27.863 1.00 21.24 ? 208  ALA B CA  1 ? 
ATOM   3965 C C   . ALA B 1 208 ? 4.147   14.530  -28.903 1.00 22.78 ? 208  ALA B C   1 ? 
ATOM   3966 O O   . ALA B 1 208 ? 3.155   15.213  -28.571 1.00 23.85 ? 208  ALA B O   1 ? 
ATOM   3967 C CB  . ALA B 1 208 ? 5.042   15.012  -26.591 1.00 21.54 ? 208  ALA B CB  1 ? 
ATOM   3968 N N   . GLY B 1 209 ? 4.345   14.064  -30.133 1.00 21.66 ? 209  GLY B N   1 ? 
ATOM   3969 C CA  . GLY B 1 209 ? 3.348   14.157  -31.219 1.00 22.66 ? 209  GLY B CA  1 ? 
ATOM   3970 C C   . GLY B 1 209 ? 3.500   15.396  -32.075 1.00 22.78 ? 209  GLY B C   1 ? 
ATOM   3971 O O   . GLY B 1 209 ? 2.781   15.496  -33.084 1.00 23.89 ? 209  GLY B O   1 ? 
ATOM   3972 N N   . GLN B 1 210 ? 4.360   16.350  -31.705 1.00 21.14 ? 210  GLN B N   1 ? 
ATOM   3973 C CA  . GLN B 1 210 ? 4.574   17.581  -32.508 1.00 19.94 ? 210  GLN B CA  1 ? 
ATOM   3974 C C   . GLN B 1 210 ? 5.312   17.250  -33.807 1.00 19.30 ? 210  GLN B C   1 ? 
ATOM   3975 O O   . GLN B 1 210 ? 5.993   16.230  -33.891 1.00 19.24 ? 210  GLN B O   1 ? 
ATOM   3976 C CB  . GLN B 1 210 ? 5.300   18.639  -31.671 1.00 19.25 ? 210  GLN B CB  1 ? 
ATOM   3977 C CG  . GLN B 1 210 ? 4.443   19.178  -30.539 1.00 19.74 ? 210  GLN B CG  1 ? 
ATOM   3978 C CD  . GLN B 1 210 ? 5.234   20.077  -29.626 1.00 22.02 ? 210  GLN B CD  1 ? 
ATOM   3979 O OE1 . GLN B 1 210 ? 5.311   21.288  -29.838 1.00 23.02 ? 210  GLN B OE1 1 ? 
ATOM   3980 N NE2 . GLN B 1 210 ? 5.819   19.476  -28.604 1.00 22.14 ? 210  GLN B NE2 1 ? 
ATOM   3981 N N   . ASP B 1 211 ? 5.117   18.072  -34.827 1.00 19.75 ? 211  ASP B N   1 ? 
ATOM   3982 C CA  . ASP B 1 211 ? 5.759   17.937  -36.156 1.00 21.54 ? 211  ASP B CA  1 ? 
ATOM   3983 C C   . ASP B 1 211 ? 7.266   17.834  -35.950 1.00 19.81 ? 211  ASP B C   1 ? 
ATOM   3984 O O   . ASP B 1 211 ? 7.829   18.689  -35.273 1.00 18.01 ? 211  ASP B O   1 ? 
ATOM   3985 C CB  . ASP B 1 211 ? 5.437   19.175  -36.990 1.00 24.59 ? 211  ASP B CB  1 ? 
ATOM   3986 C CG  . ASP B 1 211 ? 5.978   19.206  -38.409 1.00 30.89 ? 211  ASP B CG  1 ? 
ATOM   3987 O OD1 . ASP B 1 211 ? 6.913   18.440  -38.738 1.00 33.48 ? 211  ASP B OD1 1 ? 
ATOM   3988 O OD2 . ASP B 1 211 ? 5.442   20.013  -39.190 1.00 39.86 ? 211  ASP B OD2 1 ? 
ATOM   3989 N N   . PRO B 1 212 ? 7.970   16.820  -36.491 1.00 21.18 ? 212  PRO B N   1 ? 
ATOM   3990 C CA  . PRO B 1 212 ? 9.419   16.737  -36.312 1.00 20.77 ? 212  PRO B CA  1 ? 
ATOM   3991 C C   . PRO B 1 212 ? 10.197  17.878  -36.985 1.00 19.93 ? 212  PRO B C   1 ? 
ATOM   3992 O O   . PRO B 1 212 ? 11.371  18.007  -36.706 1.00 20.91 ? 212  PRO B O   1 ? 
ATOM   3993 C CB  . PRO B 1 212 ? 9.804   15.376  -36.902 1.00 22.33 ? 212  PRO B CB  1 ? 
ATOM   3994 C CG  . PRO B 1 212 ? 8.696   15.063  -37.879 1.00 23.14 ? 212  PRO B CG  1 ? 
ATOM   3995 C CD  . PRO B 1 212 ? 7.451   15.675  -37.254 1.00 22.89 ? 212  PRO B CD  1 ? 
ATOM   3996 N N   . ARG B 1 213 ? 9.552   18.693  -37.816 1.00 18.65 ? 213  ARG B N   1 ? 
ATOM   3997 C CA  . ARG B 1 213 ? 10.216  19.893  -38.405 1.00 19.31 ? 213  ARG B CA  1 ? 
ATOM   3998 C C   . ARG B 1 213 ? 9.787   21.179  -37.684 1.00 17.93 ? 213  ARG B C   1 ? 
ATOM   3999 O O   . ARG B 1 213 ? 10.089  22.260  -38.209 1.00 17.21 ? 213  ARG B O   1 ? 
ATOM   4000 C CB  . ARG B 1 213 ? 9.941   19.936  -39.905 1.00 21.75 ? 213  ARG B CB  1 ? 
ATOM   4001 C CG  . ARG B 1 213 ? 10.467  18.703  -40.623 1.00 23.74 ? 213  ARG B CG  1 ? 
ATOM   4002 C CD  . ARG B 1 213 ? 10.626  18.930  -42.106 1.00 26.95 ? 213  ARG B CD  1 ? 
ATOM   4003 N NE  . ARG B 1 213 ? 11.138  17.714  -42.709 1.00 29.47 ? 213  ARG B NE  1 ? 
ATOM   4004 C CZ  . ARG B 1 213 ? 11.644  17.614  -43.931 1.00 34.23 ? 213  ARG B CZ  1 ? 
ATOM   4005 N NH1 . ARG B 1 213 ? 11.747  18.679  -44.707 1.00 34.18 ? 213  ARG B NH1 1 ? 
ATOM   4006 N NH2 . ARG B 1 213 ? 12.083  16.442  -44.359 1.00 35.41 ? 213  ARG B NH2 1 ? 
ATOM   4007 N N   . THR B 1 214 ? 9.177   21.077  -36.502 1.00 17.11 ? 214  THR B N   1 ? 
ATOM   4008 C CA  . THR B 1 214 ? 8.878   22.233  -35.614 1.00 17.78 ? 214  THR B CA  1 ? 
ATOM   4009 C C   . THR B 1 214 ? 10.170  23.029  -35.447 1.00 16.81 ? 214  THR B C   1 ? 
ATOM   4010 O O   . THR B 1 214 ? 11.158  22.475  -34.981 1.00 16.62 ? 214  THR B O   1 ? 
ATOM   4011 C CB  . THR B 1 214 ? 8.392   21.745  -34.242 1.00 18.96 ? 214  THR B CB  1 ? 
ATOM   4012 O OG1 . THR B 1 214 ? 7.120   21.119  -34.409 1.00 19.82 ? 214  THR B OG1 1 ? 
ATOM   4013 C CG2 . THR B 1 214 ? 8.267   22.860  -33.230 1.00 20.66 ? 214  THR B CG2 1 ? 
ATOM   4014 N N   . PRO B 1 215 ? 10.245  24.300  -35.886 1.00 16.45 ? 215  PRO B N   1 ? 
ATOM   4015 C CA  . PRO B 1 215 ? 11.548  24.964  -36.006 1.00 17.20 ? 215  PRO B CA  1 ? 
ATOM   4016 C C   . PRO B 1 215 ? 12.357  25.098  -34.713 1.00 16.23 ? 215  PRO B C   1 ? 
ATOM   4017 O O   . PRO B 1 215 ? 13.581  24.998  -34.797 1.00 16.62 ? 215  PRO B O   1 ? 
ATOM   4018 C CB  . PRO B 1 215 ? 11.203  26.350  -36.569 1.00 19.51 ? 215  PRO B CB  1 ? 
ATOM   4019 C CG  . PRO B 1 215 ? 9.889   26.139  -37.287 1.00 20.64 ? 215  PRO B CG  1 ? 
ATOM   4020 C CD  . PRO B 1 215 ? 9.157   25.085  -36.479 1.00 18.51 ? 215  PRO B CD  1 ? 
ATOM   4021 N N   . LEU B 1 216 ? 11.720  25.323  -33.562 1.00 14.81 ? 216  LEU B N   1 ? 
ATOM   4022 C CA  . LEU B 1 216 ? 12.483  25.469  -32.296 1.00 15.00 ? 216  LEU B CA  1 ? 
ATOM   4023 C C   . LEU B 1 216 ? 12.858  24.091  -31.741 1.00 14.51 ? 216  LEU B C   1 ? 
ATOM   4024 O O   . LEU B 1 216 ? 13.661  24.053  -30.812 1.00 15.28 ? 216  LEU B O   1 ? 
ATOM   4025 C CB  . LEU B 1 216 ? 11.704  26.314  -31.291 1.00 16.12 ? 216  LEU B CB  1 ? 
ATOM   4026 C CG  . LEU B 1 216 ? 11.516  27.777  -31.694 1.00 17.18 ? 216  LEU B CG  1 ? 
ATOM   4027 C CD1 . LEU B 1 216 ? 10.755  28.537  -30.630 1.00 19.34 ? 216  LEU B CD1 1 ? 
ATOM   4028 C CD2 . LEU B 1 216 ? 12.855  28.463  -31.948 1.00 19.38 ? 216  LEU B CD2 1 ? 
ATOM   4029 N N   . ALA B 1 217 ? 12.353  22.982  -32.302 1.00 13.97 ? 217  ALA B N   1 ? 
ATOM   4030 C CA  . ALA B 1 217 ? 12.800  21.628  -31.926 1.00 14.76 ? 217  ALA B CA  1 ? 
ATOM   4031 C C   . ALA B 1 217 ? 13.878  21.149  -32.909 1.00 14.51 ? 217  ALA B C   1 ? 
ATOM   4032 O O   . ALA B 1 217 ? 14.802  20.405  -32.507 1.00 14.99 ? 217  ALA B O   1 ? 
ATOM   4033 C CB  . ALA B 1 217 ? 11.623  20.693  -31.855 1.00 15.16 ? 217  ALA B CB  1 ? 
ATOM   4034 N N   . ALA B 1 218 ? 13.747  21.542  -34.170 1.00 14.33 ? 218  ALA B N   1 ? 
ATOM   4035 C CA  . ALA B 1 218 ? 14.588  21.088  -35.294 1.00 14.71 ? 218  ALA B CA  1 ? 
ATOM   4036 C C   . ALA B 1 218 ? 15.058  22.302  -36.075 1.00 14.46 ? 218  ALA B C   1 ? 
ATOM   4037 O O   . ALA B 1 218 ? 14.464  22.694  -37.068 1.00 15.14 ? 218  ALA B O   1 ? 
ATOM   4038 C CB  . ALA B 1 218 ? 13.804  20.142  -36.179 1.00 15.12 ? 218  ALA B CB  1 ? 
ATOM   4039 N N   . PRO B 1 219 ? 16.093  23.014  -35.582 1.00 14.61 ? 219  PRO B N   1 ? 
ATOM   4040 C CA  . PRO B 1 219 ? 16.371  24.356  -36.096 1.00 15.08 ? 219  PRO B CA  1 ? 
ATOM   4041 C C   . PRO B 1 219 ? 17.026  24.385  -37.482 1.00 16.47 ? 219  PRO B C   1 ? 
ATOM   4042 O O   . PRO B 1 219 ? 17.208  25.471  -37.991 1.00 16.17 ? 219  PRO B O   1 ? 
ATOM   4043 C CB  . PRO B 1 219 ? 17.237  25.023  -35.021 1.00 15.78 ? 219  PRO B CB  1 ? 
ATOM   4044 C CG  . PRO B 1 219 ? 17.700  23.921  -34.124 1.00 16.32 ? 219  PRO B CG  1 ? 
ATOM   4045 C CD  . PRO B 1 219 ? 16.807  22.718  -34.332 1.00 15.26 ? 219  PRO B CD  1 ? 
ATOM   4046 N N   . LEU B 1 220 ? 17.254  23.231  -38.104 1.00 17.62 ? 220  LEU B N   1 ? 
ATOM   4047 C CA  . LEU B 1 220 ? 17.498  23.168  -39.561 1.00 19.98 ? 220  LEU B CA  1 ? 
ATOM   4048 C C   . LEU B 1 220 ? 16.366  23.887  -40.296 1.00 20.60 ? 220  LEU B C   1 ? 
ATOM   4049 O O   . LEU B 1 220 ? 16.625  24.422  -41.388 1.00 23.07 ? 220  LEU B O   1 ? 
ATOM   4050 C CB  . LEU B 1 220 ? 17.571  21.707  -39.995 1.00 22.81 ? 220  LEU B CB  1 ? 
ATOM   4051 C CG  . LEU B 1 220 ? 18.413  21.419  -41.222 1.00 27.46 ? 220  LEU B CG  1 ? 
ATOM   4052 C CD1 . LEU B 1 220 ? 19.817  22.000  -41.052 1.00 27.66 ? 220  LEU B CD1 1 ? 
ATOM   4053 C CD2 . LEU B 1 220 ? 18.475  19.914  -41.432 1.00 26.47 ? 220  LEU B CD2 1 ? 
ATOM   4054 N N   . TYR B 1 221 ? 15.166  23.938  -39.706 1.00 16.72 ? 221  TYR B N   1 ? 
ATOM   4055 C CA  . TYR B 1 221 ? 13.955  24.488  -40.365 1.00 16.98 ? 221  TYR B CA  1 ? 
ATOM   4056 C C   . TYR B 1 221 ? 13.597  25.860  -39.797 1.00 16.61 ? 221  TYR B C   1 ? 
ATOM   4057 O O   . TYR B 1 221 ? 12.548  26.407  -40.160 1.00 18.56 ? 221  TYR B O   1 ? 
ATOM   4058 C CB  . TYR B 1 221 ? 12.810  23.489  -40.245 1.00 17.61 ? 221  TYR B CB  1 ? 
ATOM   4059 C CG  . TYR B 1 221 ? 13.215  22.171  -40.833 1.00 18.95 ? 221  TYR B CG  1 ? 
ATOM   4060 C CD1 . TYR B 1 221 ? 13.390  22.036  -42.202 1.00 20.48 ? 221  TYR B CD1 1 ? 
ATOM   4061 C CD2 . TYR B 1 221 ? 13.543  21.100  -40.027 1.00 18.74 ? 221  TYR B CD2 1 ? 
ATOM   4062 C CE1 . TYR B 1 221 ? 13.848  20.857  -42.762 1.00 22.13 ? 221  TYR B CE1 1 ? 
ATOM   4063 C CE2 . TYR B 1 221 ? 13.969  19.902  -40.573 1.00 19.23 ? 221  TYR B CE2 1 ? 
ATOM   4064 C CZ  . TYR B 1 221 ? 14.128  19.782  -41.945 1.00 20.79 ? 221  TYR B CZ  1 ? 
ATOM   4065 O OH  . TYR B 1 221 ? 14.559  18.610  -42.502 1.00 21.91 ? 221  TYR B OH  1 ? 
ATOM   4066 N N   . ALA B 1 222 ? 14.456  26.426  -38.953 1.00 15.65 ? 222  ALA B N   1 ? 
ATOM   4067 C CA  . ALA B 1 222 ? 14.225  27.749  -38.351 1.00 14.99 ? 222  ALA B CA  1 ? 
ATOM   4068 C C   . ALA B 1 222 ? 14.760  28.860  -39.261 1.00 13.92 ? 222  ALA B C   1 ? 
ATOM   4069 O O   . ALA B 1 222 ? 15.629  28.615  -40.137 1.00 14.45 ? 222  ALA B O   1 ? 
ATOM   4070 C CB  . ALA B 1 222 ? 14.841  27.814  -36.969 1.00 14.08 ? 222  ALA B CB  1 ? 
ATOM   4071 N N   . ASP B 1 223 ? 14.299  30.069  -38.989 1.00 14.89 ? 223  ASP B N   1 ? 
ATOM   4072 C CA  . ASP B 1 223 ? 14.863  31.309  -39.564 1.00 15.01 ? 223  ASP B CA  1 ? 
ATOM   4073 C C   . ASP B 1 223 ? 16.153  31.652  -38.825 1.00 14.62 ? 223  ASP B C   1 ? 
ATOM   4074 O O   . ASP B 1 223 ? 16.055  32.121  -37.675 1.00 15.24 ? 223  ASP B O   1 ? 
ATOM   4075 C CB  . ASP B 1 223 ? 13.849  32.438  -39.436 1.00 16.19 ? 223  ASP B CB  1 ? 
ATOM   4076 C CG  . ASP B 1 223 ? 14.281  33.735  -40.085 1.00 17.46 ? 223  ASP B CG  1 ? 
ATOM   4077 O OD1 . ASP B 1 223 ? 15.370  33.761  -40.702 1.00 18.94 ? 223  ASP B OD1 1 ? 
ATOM   4078 O OD2 . ASP B 1 223 ? 13.526  34.684  -39.982 1.00 21.00 ? 223  ASP B OD2 1 ? 
ATOM   4079 N N   . LEU B 1 224 ? 17.308  31.481  -39.469 1.00 14.12 ? 224  LEU B N   1 ? 
ATOM   4080 C CA  . LEU B 1 224 ? 18.615  31.668  -38.799 1.00 13.67 ? 224  LEU B CA  1 ? 
ATOM   4081 C C   . LEU B 1 224 ? 19.168  33.069  -39.052 1.00 15.14 ? 224  LEU B C   1 ? 
ATOM   4082 O O   . LEU B 1 224 ? 20.280  33.347  -38.598 1.00 15.27 ? 224  LEU B O   1 ? 
ATOM   4083 C CB  . LEU B 1 224 ? 19.559  30.586  -39.303 1.00 14.28 ? 224  LEU B CB  1 ? 
ATOM   4084 C CG  . LEU B 1 224 ? 19.083  29.150  -39.072 1.00 14.33 ? 224  LEU B CG  1 ? 
ATOM   4085 C CD1 . LEU B 1 224 ? 20.160  28.148  -39.486 1.00 16.34 ? 224  LEU B CD1 1 ? 
ATOM   4086 C CD2 . LEU B 1 224 ? 18.697  28.940  -37.611 1.00 15.57 ? 224  LEU B CD2 1 ? 
ATOM   4087 N N   . ARG B 1 225 ? 18.466  33.918  -39.791 1.00 14.80 ? 225  ARG B N   1 ? 
ATOM   4088 C CA  . ARG B 1 225 ? 19.000  35.252  -40.147 1.00 15.44 ? 225  ARG B CA  1 ? 
ATOM   4089 C C   . ARG B 1 225 ? 19.269  36.030  -38.856 1.00 15.97 ? 225  ARG B C   1 ? 
ATOM   4090 O O   . ARG B 1 225 ? 18.429  36.024  -37.929 1.00 15.85 ? 225  ARG B O   1 ? 
ATOM   4091 C CB  . ARG B 1 225 ? 18.058  35.958  -41.123 1.00 14.90 ? 225  ARG B CB  1 ? 
ATOM   4092 C CG  . ARG B 1 225 ? 17.923  35.262  -42.479 1.00 15.02 ? 225  ARG B CG  1 ? 
ATOM   4093 C CD  . ARG B 1 225 ? 16.852  35.863  -43.358 1.00 14.32 ? 225  ARG B CD  1 ? 
ATOM   4094 N NE  . ARG B 1 225 ? 15.541  35.732  -42.733 1.00 15.22 ? 225  ARG B NE  1 ? 
ATOM   4095 C CZ  . ARG B 1 225 ? 14.449  36.385  -43.114 1.00 14.91 ? 225  ARG B CZ  1 ? 
ATOM   4096 N NH1 . ARG B 1 225 ? 13.322  36.204  -42.444 1.00 17.08 ? 225  ARG B NH1 1 ? 
ATOM   4097 N NH2 . ARG B 1 225 ? 14.487  37.188  -44.159 1.00 15.49 ? 225  ARG B NH2 1 ? 
ATOM   4098 N N   . GLY B 1 226 ? 20.452  36.640  -38.776 1.00 16.61 ? 226  GLY B N   1 ? 
ATOM   4099 C CA  . GLY B 1 226 ? 20.770  37.570  -37.684 1.00 17.19 ? 226  GLY B CA  1 ? 
ATOM   4100 C C   . GLY B 1 226 ? 21.549  36.898  -36.572 1.00 16.29 ? 226  GLY B C   1 ? 
ATOM   4101 O O   . GLY B 1 226 ? 21.945  37.601  -35.613 1.00 16.31 ? 226  GLY B O   1 ? 
ATOM   4102 N N   . LEU B 1 227 ? 21.749  35.588  -36.648 1.00 15.36 ? 227  LEU B N   1 ? 
ATOM   4103 C CA  . LEU B 1 227 ? 22.483  34.880  -35.579 1.00 15.99 ? 227  LEU B CA  1 ? 
ATOM   4104 C C   . LEU B 1 227 ? 23.937  35.315  -35.581 1.00 15.57 ? 227  LEU B C   1 ? 
ATOM   4105 O O   . LEU B 1 227 ? 24.510  35.709  -36.602 1.00 15.51 ? 227  LEU B O   1 ? 
ATOM   4106 C CB  . LEU B 1 227 ? 22.350  33.372  -35.740 1.00 15.70 ? 227  LEU B CB  1 ? 
ATOM   4107 C CG  . LEU B 1 227 ? 21.269  32.752  -34.862 1.00 17.27 ? 227  LEU B CG  1 ? 
ATOM   4108 C CD1 . LEU B 1 227 ? 19.920  33.418  -35.076 1.00 17.49 ? 227  LEU B CD1 1 ? 
ATOM   4109 C CD2 . LEU B 1 227 ? 21.209  31.248  -35.079 1.00 18.22 ? 227  LEU B CD2 1 ? 
ATOM   4110 N N   . PRO B 1 228 ? 24.575  35.271  -34.394 1.00 15.61 ? 228  PRO B N   1 ? 
ATOM   4111 C CA  . PRO B 1 228 ? 25.967  35.677  -34.272 1.00 15.09 ? 228  PRO B CA  1 ? 
ATOM   4112 C C   . PRO B 1 228 ? 26.895  34.612  -34.829 1.00 14.28 ? 228  PRO B C   1 ? 
ATOM   4113 O O   . PRO B 1 228 ? 26.460  33.504  -35.174 1.00 15.99 ? 228  PRO B O   1 ? 
ATOM   4114 C CB  . PRO B 1 228 ? 26.135  35.819  -32.760 1.00 15.87 ? 228  PRO B CB  1 ? 
ATOM   4115 C CG  . PRO B 1 228 ? 25.199  34.786  -32.187 1.00 14.98 ? 228  PRO B CG  1 ? 
ATOM   4116 C CD  . PRO B 1 228 ? 24.014  34.778  -33.126 1.00 14.82 ? 228  PRO B CD  1 ? 
ATOM   4117 N N   . PRO B 1 229 ? 28.207  34.914  -34.928 1.00 14.36 ? 229  PRO B N   1 ? 
ATOM   4118 C CA  . PRO B 1 229 ? 29.172  33.960  -35.433 1.00 14.36 ? 229  PRO B CA  1 ? 
ATOM   4119 C C   . PRO B 1 229 ? 29.109  32.624  -34.690 1.00 14.09 ? 229  PRO B C   1 ? 
ATOM   4120 O O   . PRO B 1 229 ? 29.029  32.604  -33.461 1.00 13.30 ? 229  PRO B O   1 ? 
ATOM   4121 C CB  . PRO B 1 229 ? 30.512  34.634  -35.197 1.00 15.20 ? 229  PRO B CB  1 ? 
ATOM   4122 C CG  . PRO B 1 229 ? 30.179  36.089  -35.254 1.00 16.18 ? 229  PRO B CG  1 ? 
ATOM   4123 C CD  . PRO B 1 229 ? 28.808  36.224  -34.628 1.00 15.43 ? 229  PRO B CD  1 ? 
ATOM   4124 N N   A LEU B 1 230 ? 29.063  31.541  -35.470 0.50 13.89 ? 230  LEU B N   1 ? 
ATOM   4125 N N   B LEU B 1 230 ? 29.189  31.543  -35.450 0.50 14.54 ? 230  LEU B N   1 ? 
ATOM   4126 C CA  A LEU B 1 230 ? 28.923  30.147  -34.987 0.50 13.18 ? 230  LEU B CA  1 ? 
ATOM   4127 C CA  B LEU B 1 230 ? 28.900  30.173  -34.976 0.50 14.08 ? 230  LEU B CA  1 ? 
ATOM   4128 C C   A LEU B 1 230 ? 30.220  29.396  -35.256 0.50 13.20 ? 230  LEU B C   1 ? 
ATOM   4129 C C   B LEU B 1 230 ? 30.090  29.264  -35.291 0.50 13.71 ? 230  LEU B C   1 ? 
ATOM   4130 O O   A LEU B 1 230 ? 30.800  29.559  -36.341 0.50 14.23 ? 230  LEU B O   1 ? 
ATOM   4131 O O   B LEU B 1 230 ? 30.460  29.137  -36.477 0.50 13.76 ? 230  LEU B O   1 ? 
ATOM   4132 C CB  A LEU B 1 230 ? 27.783  29.408  -35.690 0.50 13.23 ? 230  LEU B CB  1 ? 
ATOM   4133 C CB  B LEU B 1 230 ? 27.611  29.720  -35.666 0.50 14.93 ? 230  LEU B CB  1 ? 
ATOM   4134 C CG  A LEU B 1 230 ? 26.404  30.052  -35.662 0.50 13.16 ? 230  LEU B CG  1 ? 
ATOM   4135 C CG  B LEU B 1 230 ? 27.238  28.258  -35.463 0.50 15.70 ? 230  LEU B CG  1 ? 
ATOM   4136 C CD1 A LEU B 1 230 ? 25.401  29.126  -36.342 0.50 13.15 ? 230  LEU B CD1 1 ? 
ATOM   4137 C CD1 B LEU B 1 230 ? 26.975  27.961  -34.001 0.50 16.37 ? 230  LEU B CD1 1 ? 
ATOM   4138 C CD2 A LEU B 1 230 ? 25.947  30.383  -34.254 0.50 13.75 ? 230  LEU B CD2 1 ? 
ATOM   4139 C CD2 B LEU B 1 230 ? 26.038  27.886  -36.322 0.50 16.27 ? 230  LEU B CD2 1 ? 
ATOM   4140 N N   . LEU B 1 231 ? 30.653  28.627  -34.264 1.00 12.44 ? 231  LEU B N   1 ? 
ATOM   4141 C CA  . LEU B 1 231 ? 31.658  27.569  -34.428 1.00 12.65 ? 231  LEU B CA  1 ? 
ATOM   4142 C C   . LEU B 1 231 ? 30.898  26.266  -34.372 1.00 12.99 ? 231  LEU B C   1 ? 
ATOM   4143 O O   . LEU B 1 231 ? 30.218  26.032  -33.365 1.00 13.56 ? 231  LEU B O   1 ? 
ATOM   4144 C CB  . LEU B 1 231 ? 32.686  27.632  -33.303 1.00 13.44 ? 231  LEU B CB  1 ? 
ATOM   4145 C CG  . LEU B 1 231 ? 33.677  26.479  -33.263 1.00 13.14 ? 231  LEU B CG  1 ? 
ATOM   4146 C CD1 . LEU B 1 231 ? 34.520  26.415  -34.522 1.00 13.99 ? 231  LEU B CD1 1 ? 
ATOM   4147 C CD2 . LEU B 1 231 ? 34.555  26.574  -32.032 1.00 13.87 ? 231  LEU B CD2 1 ? 
ATOM   4148 N N   . ILE B 1 232 ? 31.023  25.441  -35.399 1.00 12.05 ? 232  ILE B N   1 ? 
ATOM   4149 C CA  . ILE B 1 232 ? 30.462  24.070  -35.408 1.00 12.93 ? 232  ILE B CA  1 ? 
ATOM   4150 C C   . ILE B 1 232 ? 31.635  23.121  -35.476 1.00 13.46 ? 232  ILE B C   1 ? 
ATOM   4151 O O   . ILE B 1 232 ? 32.375  23.147  -36.471 1.00 13.32 ? 232  ILE B O   1 ? 
ATOM   4152 C CB  . ILE B 1 232 ? 29.500  23.835  -36.581 1.00 12.34 ? 232  ILE B CB  1 ? 
ATOM   4153 C CG1 . ILE B 1 232 ? 28.374  24.869  -36.614 1.00 13.28 ? 232  ILE B CG1 1 ? 
ATOM   4154 C CG2 . ILE B 1 232 ? 28.968  22.407  -36.536 1.00 13.06 ? 232  ILE B CG2 1 ? 
ATOM   4155 C CD1 . ILE B 1 232 ? 27.544  24.884  -37.890 1.00 13.91 ? 232  ILE B CD1 1 ? 
ATOM   4156 N N   . GLN B 1 233 ? 31.833  22.330  -34.432 1.00 12.62 ? 233  GLN B N   1 ? 
ATOM   4157 C CA  . GLN B 1 233 ? 32.856  21.272  -34.416 1.00 13.15 ? 233  GLN B CA  1 ? 
ATOM   4158 C C   . GLN B 1 233 ? 32.122  19.950  -34.515 1.00 13.86 ? 233  GLN B C   1 ? 
ATOM   4159 O O   . GLN B 1 233 ? 31.097  19.771  -33.824 1.00 15.23 ? 233  GLN B O   1 ? 
ATOM   4160 C CB  . GLN B 1 233 ? 33.723  21.293  -33.160 1.00 13.21 ? 233  GLN B CB  1 ? 
ATOM   4161 C CG  . GLN B 1 233 ? 34.693  22.458  -33.095 1.00 14.27 ? 233  GLN B CG  1 ? 
ATOM   4162 C CD  . GLN B 1 233 ? 35.643  22.353  -31.920 1.00 14.92 ? 233  GLN B CD  1 ? 
ATOM   4163 O OE1 . GLN B 1 233 ? 35.329  21.734  -30.904 1.00 14.38 ? 233  GLN B OE1 1 ? 
ATOM   4164 N NE2 . GLN B 1 233 ? 36.801  22.991  -32.028 1.00 15.74 ? 233  GLN B NE2 1 ? 
ATOM   4165 N N   . VAL B 1 234 ? 32.563  19.086  -35.409 1.00 12.79 ? 234  VAL B N   1 ? 
ATOM   4166 C CA  . VAL B 1 234 ? 31.894  17.782  -35.653 1.00 13.41 ? 234  VAL B CA  1 ? 
ATOM   4167 C C   . VAL B 1 234 ? 32.968  16.780  -36.056 1.00 13.57 ? 234  VAL B C   1 ? 
ATOM   4168 O O   . VAL B 1 234 ? 34.000  17.185  -36.609 1.00 13.60 ? 234  VAL B O   1 ? 
ATOM   4169 C CB  . VAL B 1 234 ? 30.788  17.926  -36.719 1.00 13.09 ? 234  VAL B CB  1 ? 
ATOM   4170 C CG1 . VAL B 1 234 ? 31.370  18.335  -38.062 1.00 12.50 ? 234  VAL B CG1 1 ? 
ATOM   4171 C CG2 . VAL B 1 234 ? 29.962  16.658  -36.857 1.00 13.93 ? 234  VAL B CG2 1 ? 
ATOM   4172 N N   . GLY B 1 235 ? 32.774  15.523  -35.713 1.00 13.77 ? 235  GLY B N   1 ? 
ATOM   4173 C CA  . GLY B 1 235 ? 33.711  14.480  -36.143 1.00 14.17 ? 235  GLY B CA  1 ? 
ATOM   4174 C C   . GLY B 1 235 ? 33.329  13.893  -37.490 1.00 16.91 ? 235  GLY B C   1 ? 
ATOM   4175 O O   . GLY B 1 235 ? 32.126  13.799  -37.780 1.00 16.40 ? 235  GLY B O   1 ? 
ATOM   4176 N N   . THR B 1 236 ? 34.289  13.445  -38.297 1.00 16.45 ? 236  THR B N   1 ? 
ATOM   4177 C CA  . THR B 1 236 ? 33.938  12.856  -39.622 1.00 16.76 ? 236  THR B CA  1 ? 
ATOM   4178 C C   . THR B 1 236 ? 33.449  11.418  -39.448 1.00 17.71 ? 236  THR B C   1 ? 
ATOM   4179 O O   . THR B 1 236 ? 32.853  10.880  -40.402 1.00 19.27 ? 236  THR B O   1 ? 
ATOM   4180 C CB  . THR B 1 236 ? 35.096  12.947  -40.619 1.00 17.69 ? 236  THR B CB  1 ? 
ATOM   4181 O OG1 . THR B 1 236 ? 36.135  12.076  -40.169 1.00 19.15 ? 236  THR B OG1 1 ? 
ATOM   4182 C CG2 . THR B 1 236 ? 35.610  14.357  -40.803 1.00 18.17 ? 236  THR B CG2 1 ? 
ATOM   4183 N N   . ALA B 1 237 ? 33.623  10.825  -38.270 1.00 16.76 ? 237  ALA B N   1 ? 
ATOM   4184 C CA  . ALA B 1 237 ? 33.117  9.473   -37.943 1.00 17.11 ? 237  ALA B CA  1 ? 
ATOM   4185 C C   . ALA B 1 237 ? 31.802  9.608   -37.172 1.00 18.21 ? 237  ALA B C   1 ? 
ATOM   4186 O O   . ALA B 1 237 ? 31.673  9.023   -36.053 1.00 23.01 ? 237  ALA B O   1 ? 
ATOM   4187 C CB  . ALA B 1 237 ? 34.170  8.727   -37.163 1.00 17.20 ? 237  ALA B CB  1 ? 
ATOM   4188 N N   . GLU B 1 238 ? 30.905  10.442  -37.677 1.00 16.70 ? 238  GLU B N   1 ? 
ATOM   4189 C CA  . GLU B 1 238 ? 29.602  10.716  -37.017 1.00 15.79 ? 238  GLU B CA  1 ? 
ATOM   4190 C C   . GLU B 1 238 ? 28.448  10.531  -37.991 1.00 14.98 ? 238  GLU B C   1 ? 
ATOM   4191 O O   . GLU B 1 238 ? 28.447  11.141  -39.076 1.00 16.03 ? 238  GLU B O   1 ? 
ATOM   4192 C CB  . GLU B 1 238 ? 29.562  12.149  -36.492 1.00 14.70 ? 238  GLU B CB  1 ? 
ATOM   4193 C CG  . GLU B 1 238 ? 30.392  12.350  -35.254 1.00 15.70 ? 238  GLU B CG  1 ? 
ATOM   4194 C CD  . GLU B 1 238 ? 29.849  13.466  -34.385 1.00 15.41 ? 238  GLU B CD  1 ? 
ATOM   4195 O OE1 . GLU B 1 238 ? 28.691  13.310  -33.892 1.00 15.45 ? 238  GLU B OE1 1 ? 
ATOM   4196 O OE2 . GLU B 1 238 ? 30.565  14.473  -34.199 1.00 15.61 ? 238  GLU B OE2 1 ? 
ATOM   4197 N N   . THR B 1 239 ? 27.437  9.792   -37.563 1.00 14.57 ? 239  THR B N   1 ? 
ATOM   4198 C CA  . THR B 1 239 ? 26.143  9.787   -38.271 1.00 14.62 ? 239  THR B CA  1 ? 
ATOM   4199 C C   . THR B 1 239 ? 25.556  11.195  -38.266 1.00 14.82 ? 239  THR B C   1 ? 
ATOM   4200 O O   . THR B 1 239 ? 24.840  11.504  -39.208 1.00 14.54 ? 239  THR B O   1 ? 
ATOM   4201 C CB  . THR B 1 239 ? 25.157  8.788   -37.672 1.00 15.61 ? 239  THR B CB  1 ? 
ATOM   4202 O OG1 . THR B 1 239 ? 25.033  9.016   -36.275 1.00 14.41 ? 239  THR B OG1 1 ? 
ATOM   4203 C CG2 . THR B 1 239 ? 25.564  7.354   -37.942 1.00 16.62 ? 239  THR B CG2 1 ? 
ATOM   4204 N N   . LEU B 1 240 ? 25.855  12.024  -37.262 1.00 14.25 ? 240  LEU B N   1 ? 
ATOM   4205 C CA  . LEU B 1 240 ? 25.372  13.430  -37.242 1.00 13.52 ? 240  LEU B CA  1 ? 
ATOM   4206 C C   . LEU B 1 240 ? 26.261  14.376  -38.064 1.00 13.78 ? 240  LEU B C   1 ? 
ATOM   4207 O O   . LEU B 1 240 ? 26.001  15.589  -38.040 1.00 13.34 ? 240  LEU B O   1 ? 
ATOM   4208 C CB  . LEU B 1 240 ? 25.246  13.908  -35.793 1.00 14.08 ? 240  LEU B CB  1 ? 
ATOM   4209 C CG  . LEU B 1 240 ? 24.135  13.232  -34.993 1.00 14.59 ? 240  LEU B CG  1 ? 
ATOM   4210 C CD1 . LEU B 1 240 ? 24.208  13.621  -33.529 1.00 15.18 ? 240  LEU B CD1 1 ? 
ATOM   4211 C CD2 . LEU B 1 240 ? 22.758  13.588  -35.564 1.00 14.97 ? 240  LEU B CD2 1 ? 
ATOM   4212 N N   . LEU B 1 241 ? 27.226  13.882  -38.842 1.00 13.37 ? 241  LEU B N   1 ? 
ATOM   4213 C CA  . LEU B 1 241 ? 28.078  14.774  -39.665 1.00 13.64 ? 241  LEU B CA  1 ? 
ATOM   4214 C C   . LEU B 1 241 ? 27.200  15.654  -40.552 1.00 13.60 ? 241  LEU B C   1 ? 
ATOM   4215 O O   . LEU B 1 241 ? 27.419  16.854  -40.597 1.00 13.82 ? 241  LEU B O   1 ? 
ATOM   4216 C CB  . LEU B 1 241 ? 29.050  13.950  -40.513 1.00 14.09 ? 241  LEU B CB  1 ? 
ATOM   4217 C CG  . LEU B 1 241 ? 29.858  14.761  -41.524 1.00 14.74 ? 241  LEU B CG  1 ? 
ATOM   4218 C CD1 . LEU B 1 241 ? 30.683  15.832  -40.824 1.00 15.64 ? 241  LEU B CD1 1 ? 
ATOM   4219 C CD2 . LEU B 1 241 ? 30.755  13.861  -42.346 1.00 16.41 ? 241  LEU B CD2 1 ? 
ATOM   4220 N N   . ASP B 1 242 ? 26.191  15.086  -41.214 1.00 15.00 ? 242  ASP B N   1 ? 
ATOM   4221 C CA  . ASP B 1 242 ? 25.369  15.885  -42.150 1.00 15.91 ? 242  ASP B CA  1 ? 
ATOM   4222 C C   . ASP B 1 242 ? 24.427  16.838  -41.403 1.00 15.37 ? 242  ASP B C   1 ? 
ATOM   4223 O O   . ASP B 1 242 ? 23.973  17.780  -42.027 1.00 15.23 ? 242  ASP B O   1 ? 
ATOM   4224 C CB  . ASP B 1 242 ? 24.647  15.000  -43.154 1.00 17.66 ? 242  ASP B CB  1 ? 
ATOM   4225 C CG  . ASP B 1 242 ? 25.584  14.652  -44.297 1.00 21.95 ? 242  ASP B CG  1 ? 
ATOM   4226 O OD1 . ASP B 1 242 ? 26.416  15.529  -44.676 1.00 24.46 ? 242  ASP B OD1 1 ? 
ATOM   4227 O OD2 . ASP B 1 242 ? 25.517  13.513  -44.781 1.00 25.57 ? 242  ASP B OD2 1 ? 
ATOM   4228 N N   . ASP B 1 243 ? 24.176  16.651  -40.107 1.00 14.33 ? 243  ASP B N   1 ? 
ATOM   4229 C CA  . ASP B 1 243 ? 23.464  17.689  -39.321 1.00 14.26 ? 243  ASP B CA  1 ? 
ATOM   4230 C C   . ASP B 1 243 ? 24.318  18.960  -39.317 1.00 13.74 ? 243  ASP B C   1 ? 
ATOM   4231 O O   . ASP B 1 243 ? 23.753  20.038  -39.494 1.00 13.68 ? 243  ASP B O   1 ? 
ATOM   4232 C CB  . ASP B 1 243 ? 23.157  17.265  -37.884 1.00 14.17 ? 243  ASP B CB  1 ? 
ATOM   4233 C CG  . ASP B 1 243 ? 21.948  16.361  -37.789 1.00 15.57 ? 243  ASP B CG  1 ? 
ATOM   4234 O OD1 . ASP B 1 243 ? 21.903  15.377  -38.585 1.00 16.17 ? 243  ASP B OD1 1 ? 
ATOM   4235 O OD2 . ASP B 1 243 ? 21.094  16.607  -36.924 1.00 14.39 ? 243  ASP B OD2 1 ? 
ATOM   4236 N N   . SER B 1 244 ? 25.633  18.825  -39.094 1.00 12.29 ? 244  SER B N   1 ? 
ATOM   4237 C CA  . SER B 1 244 ? 26.568  19.968  -39.054 1.00 12.92 ? 244  SER B CA  1 ? 
ATOM   4238 C C   . SER B 1 244 ? 26.691  20.568  -40.452 1.00 12.81 ? 244  SER B C   1 ? 
ATOM   4239 O O   . SER B 1 244 ? 26.675  21.795  -40.563 1.00 13.96 ? 244  SER B O   1 ? 
ATOM   4240 C CB  . SER B 1 244 ? 27.898  19.570  -38.504 1.00 12.70 ? 244  SER B CB  1 ? 
ATOM   4241 O OG  . SER B 1 244 ? 27.801  19.435  -37.084 1.00 12.78 ? 244  SER B OG  1 ? 
ATOM   4242 N N   . VAL B 1 245 ? 26.824  19.731  -41.473 1.00 13.08 ? 245  VAL B N   1 ? 
ATOM   4243 C CA  . VAL B 1 245 ? 27.013  20.233  -42.858 1.00 13.98 ? 245  VAL B CA  1 ? 
ATOM   4244 C C   . VAL B 1 245 ? 25.758  21.019  -43.245 1.00 13.29 ? 245  VAL B C   1 ? 
ATOM   4245 O O   . VAL B 1 245 ? 25.884  22.125  -43.793 1.00 14.31 ? 245  VAL B O   1 ? 
ATOM   4246 C CB  . VAL B 1 245 ? 27.289  19.071  -43.825 1.00 15.41 ? 245  VAL B CB  1 ? 
ATOM   4247 C CG1 . VAL B 1 245 ? 27.218  19.510  -45.285 1.00 16.43 ? 245  VAL B CG1 1 ? 
ATOM   4248 C CG2 . VAL B 1 245 ? 28.628  18.410  -43.525 1.00 16.42 ? 245  VAL B CG2 1 ? 
ATOM   4249 N N   . ARG B 1 246 ? 24.576  20.461  -42.994 1.00 13.19 ? 246  ARG B N   1 ? 
ATOM   4250 C CA  . ARG B 1 246 ? 23.315  21.135  -43.364 1.00 13.38 ? 246  ARG B CA  1 ? 
ATOM   4251 C C   . ARG B 1 246 ? 23.128  22.391  -42.510 1.00 13.44 ? 246  ARG B C   1 ? 
ATOM   4252 O O   . ARG B 1 246 ? 22.645  23.414  -43.034 1.00 14.08 ? 246  ARG B O   1 ? 
ATOM   4253 C CB  . ARG B 1 246 ? 22.119  20.189  -43.247 1.00 14.52 ? 246  ARG B CB  1 ? 
ATOM   4254 C CG  . ARG B 1 246 ? 22.098  19.136  -44.341 1.00 14.77 ? 246  ARG B CG  1 ? 
ATOM   4255 C CD  . ARG B 1 246 ? 20.986  18.144  -44.095 1.00 15.30 ? 246  ARG B CD  1 ? 
ATOM   4256 N NE  . ARG B 1 246 ? 21.216  17.333  -42.925 1.00 15.50 ? 246  ARG B NE  1 ? 
ATOM   4257 C CZ  . ARG B 1 246 ? 20.343  16.486  -42.401 1.00 15.93 ? 246  ARG B CZ  1 ? 
ATOM   4258 N NH1 . ARG B 1 246 ? 19.134  16.383  -42.928 1.00 15.99 ? 246  ARG B NH1 1 ? 
ATOM   4259 N NH2 . ARG B 1 246 ? 20.655  15.786  -41.324 1.00 14.92 ? 246  ARG B NH2 1 ? 
ATOM   4260 N N   . LEU B 1 247 ? 23.491  22.359  -41.233 1.00 12.21 ? 247  LEU B N   1 ? 
ATOM   4261 C CA  . LEU B 1 247 ? 23.373  23.568  -40.392 1.00 12.54 ? 247  LEU B CA  1 ? 
ATOM   4262 C C   . LEU B 1 247 ? 24.265  24.673  -40.966 1.00 12.53 ? 247  LEU B C   1 ? 
ATOM   4263 O O   . LEU B 1 247 ? 23.800  25.811  -41.040 1.00 13.36 ? 247  LEU B O   1 ? 
ATOM   4264 C CB  . LEU B 1 247 ? 23.728  23.235  -38.946 1.00 13.00 ? 247  LEU B CB  1 ? 
ATOM   4265 C CG  . LEU B 1 247 ? 23.678  24.419  -37.989 1.00 13.61 ? 247  LEU B CG  1 ? 
ATOM   4266 C CD1 . LEU B 1 247 ? 22.299  25.058  -37.930 1.00 13.71 ? 247  LEU B CD1 1 ? 
ATOM   4267 C CD2 . LEU B 1 247 ? 24.094  23.955  -36.589 1.00 13.67 ? 247  LEU B CD2 1 ? 
ATOM   4268 N N   . ALA B 1 248 ? 25.519  24.356  -41.299 1.00 13.25 ? 248  ALA B N   1 ? 
ATOM   4269 C CA  . ALA B 1 248 ? 26.464  25.351  -41.844 1.00 13.34 ? 248  ALA B CA  1 ? 
ATOM   4270 C C   . ALA B 1 248 ? 25.885  25.919  -43.144 1.00 14.28 ? 248  ALA B C   1 ? 
ATOM   4271 O O   . ALA B 1 248 ? 25.906  27.129  -43.304 1.00 13.84 ? 248  ALA B O   1 ? 
ATOM   4272 C CB  . ALA B 1 248 ? 27.809  24.734  -42.051 1.00 13.95 ? 248  ALA B CB  1 ? 
ATOM   4273 N N   A GLU B 1 249 ? 25.365  25.063  -44.030 0.50 14.13 ? 249  GLU B N   1 ? 
ATOM   4274 N N   B GLU B 1 249 ? 25.387  25.040  -44.020 0.50 13.98 ? 249  GLU B N   1 ? 
ATOM   4275 C CA  A GLU B 1 249 ? 24.766  25.511  -45.319 0.50 15.29 ? 249  GLU B CA  1 ? 
ATOM   4276 C CA  B GLU B 1 249 ? 24.749  25.400  -45.316 0.50 15.13 ? 249  GLU B CA  1 ? 
ATOM   4277 C C   A GLU B 1 249 ? 23.618  26.474  -45.029 0.50 15.15 ? 249  GLU B C   1 ? 
ATOM   4278 C C   B GLU B 1 249 ? 23.619  26.406  -45.070 0.50 14.98 ? 249  GLU B C   1 ? 
ATOM   4279 O O   A GLU B 1 249 ? 23.576  27.567  -45.614 0.50 15.30 ? 249  GLU B O   1 ? 
ATOM   4280 O O   B GLU B 1 249 ? 23.623  27.470  -45.720 0.50 15.02 ? 249  GLU B O   1 ? 
ATOM   4281 C CB  A GLU B 1 249 ? 24.197  24.350  -46.142 0.50 16.35 ? 249  GLU B CB  1 ? 
ATOM   4282 C CB  B GLU B 1 249 ? 24.229  24.132  -46.000 0.50 15.97 ? 249  GLU B CB  1 ? 
ATOM   4283 C CG  A GLU B 1 249 ? 23.502  24.803  -47.428 0.50 18.55 ? 249  GLU B CG  1 ? 
ATOM   4284 C CG  B GLU B 1 249 ? 23.338  24.388  -47.198 0.50 17.95 ? 249  GLU B CG  1 ? 
ATOM   4285 C CD  A GLU B 1 249 ? 22.032  25.208  -47.332 0.50 20.87 ? 249  GLU B CD  1 ? 
ATOM   4286 C CD  B GLU B 1 249 ? 22.421  23.224  -47.543 0.50 20.08 ? 249  GLU B CD  1 ? 
ATOM   4287 O OE1 A GLU B 1 249 ? 21.615  26.182  -48.019 0.50 23.57 ? 249  GLU B OE1 1 ? 
ATOM   4288 O OE1 B GLU B 1 249 ? 22.180  22.376  -46.656 0.50 22.57 ? 249  GLU B OE1 1 ? 
ATOM   4289 O OE2 A GLU B 1 249 ? 21.282  24.524  -46.604 0.50 22.41 ? 249  GLU B OE2 1 ? 
ATOM   4290 O OE2 B GLU B 1 249 ? 21.939  23.174  -48.690 0.50 23.08 ? 249  GLU B OE2 1 ? 
ATOM   4291 N N   . ARG B 1 250 ? 22.696  26.079  -44.160 1.00 15.47 ? 250  ARG B N   1 ? 
ATOM   4292 C CA  . ARG B 1 250 ? 21.491  26.889  -43.897 1.00 16.52 ? 250  ARG B CA  1 ? 
ATOM   4293 C C   . ARG B 1 250 ? 21.885  28.197  -43.211 1.00 15.35 ? 250  ARG B C   1 ? 
ATOM   4294 O O   . ARG B 1 250 ? 21.343  29.253  -43.563 1.00 15.18 ? 250  ARG B O   1 ? 
ATOM   4295 C CB  . ARG B 1 250 ? 20.509  26.082  -43.053 1.00 19.69 ? 250  ARG B CB  1 ? 
ATOM   4296 C CG  . ARG B 1 250 ? 19.788  25.036  -43.892 1.00 25.54 ? 250  ARG B CG  1 ? 
ATOM   4297 C CD  . ARG B 1 250 ? 18.556  25.628  -44.551 1.00 31.31 ? 250  ARG B CD  1 ? 
ATOM   4298 N NE  . ARG B 1 250 ? 17.657  26.018  -43.469 1.00 37.03 ? 250  ARG B NE  1 ? 
ATOM   4299 C CZ  . ARG B 1 250 ? 16.607  26.834  -43.558 1.00 38.15 ? 250  ARG B CZ  1 ? 
ATOM   4300 N NH1 . ARG B 1 250 ? 16.279  27.396  -44.712 1.00 41.08 ? 250  ARG B NH1 1 ? 
ATOM   4301 N NH2 . ARG B 1 250 ? 15.897  27.093  -42.468 1.00 34.64 ? 250  ARG B NH2 1 ? 
ATOM   4302 N N   . ALA B 1 251 ? 22.804  28.146  -42.254 1.00 13.51 ? 251  ALA B N   1 ? 
ATOM   4303 C CA  . ALA B 1 251 ? 23.229  29.344  -41.519 1.00 13.02 ? 251  ALA B CA  1 ? 
ATOM   4304 C C   . ALA B 1 251 ? 23.951  30.291  -42.494 1.00 12.32 ? 251  ALA B C   1 ? 
ATOM   4305 O O   . ALA B 1 251 ? 23.641  31.468  -42.480 1.00 12.01 ? 251  ALA B O   1 ? 
ATOM   4306 C CB  . ALA B 1 251 ? 24.075  28.945  -40.335 1.00 13.65 ? 251  ALA B CB  1 ? 
ATOM   4307 N N   . ARG B 1 252 ? 24.858  29.789  -43.317 1.00 12.47 ? 252  ARG B N   1 ? 
ATOM   4308 C CA  . ARG B 1 252 ? 25.544  30.656  -44.315 1.00 13.35 ? 252  ARG B CA  1 ? 
ATOM   4309 C C   . ARG B 1 252 ? 24.518  31.247  -45.284 1.00 13.80 ? 252  ARG B C   1 ? 
ATOM   4310 O O   . ARG B 1 252 ? 24.664  32.437  -45.637 1.00 14.24 ? 252  ARG B O   1 ? 
ATOM   4311 C CB  . ARG B 1 252 ? 26.625  29.877  -45.039 1.00 13.52 ? 252  ARG B CB  1 ? 
ATOM   4312 C CG  . ARG B 1 252 ? 27.814  29.582  -44.130 1.00 14.04 ? 252  ARG B CG  1 ? 
ATOM   4313 C CD  . ARG B 1 252 ? 28.768  28.596  -44.729 1.00 14.00 ? 252  ARG B CD  1 ? 
ATOM   4314 N NE  . ARG B 1 252 ? 30.032  28.617  -43.978 1.00 14.27 ? 252  ARG B NE  1 ? 
ATOM   4315 C CZ  . ARG B 1 252 ? 30.899  27.611  -43.926 1.00 14.56 ? 252  ARG B CZ  1 ? 
ATOM   4316 N NH1 . ARG B 1 252 ? 30.726  26.488  -44.602 1.00 14.79 ? 252  ARG B NH1 1 ? 
ATOM   4317 N NH2 . ARG B 1 252 ? 31.997  27.757  -43.207 1.00 16.17 ? 252  ARG B NH2 1 ? 
ATOM   4318 N N   . ALA B 1 253 ? 23.497  30.479  -45.684 1.00 13.77 ? 253  ALA B N   1 ? 
ATOM   4319 C CA  . ALA B 1 253 ? 22.446  30.976  -46.600 1.00 14.11 ? 253  ALA B CA  1 ? 
ATOM   4320 C C   . ALA B 1 253 ? 21.619  32.078  -45.933 1.00 14.10 ? 253  ALA B C   1 ? 
ATOM   4321 O O   . ALA B 1 253 ? 20.994  32.858  -46.654 1.00 14.46 ? 253  ALA B O   1 ? 
ATOM   4322 C CB  . ALA B 1 253 ? 21.584  29.838  -47.080 1.00 14.64 ? 253  ALA B CB  1 ? 
ATOM   4323 N N   . ALA B 1 254 ? 21.597  32.122  -44.598 1.00 13.01 ? 254  ALA B N   1 ? 
ATOM   4324 C CA  . ALA B 1 254 ? 20.898  33.145  -43.795 1.00 13.39 ? 254  ALA B CA  1 ? 
ATOM   4325 C C   . ALA B 1 254 ? 21.841  34.294  -43.413 1.00 13.60 ? 254  ALA B C   1 ? 
ATOM   4326 O O   . ALA B 1 254 ? 21.436  35.150  -42.632 1.00 15.31 ? 254  ALA B O   1 ? 
ATOM   4327 C CB  . ALA B 1 254 ? 20.341  32.493  -42.562 1.00 13.27 ? 254  ALA B CB  1 ? 
ATOM   4328 N N   . GLY B 1 255 ? 23.084  34.288  -43.888 1.00 13.83 ? 255  GLY B N   1 ? 
ATOM   4329 C CA  . GLY B 1 255 ? 24.048  35.390  -43.660 1.00 14.09 ? 255  GLY B CA  1 ? 
ATOM   4330 C C   . GLY B 1 255 ? 24.821  35.282  -42.355 1.00 15.74 ? 255  GLY B C   1 ? 
ATOM   4331 O O   . GLY B 1 255 ? 25.425  36.286  -41.923 1.00 17.34 ? 255  GLY B O   1 ? 
ATOM   4332 N N   . VAL B 1 256 ? 24.779  34.131  -41.706 1.00 14.67 ? 256  VAL B N   1 ? 
ATOM   4333 C CA  . VAL B 1 256 ? 25.541  33.902  -40.447 1.00 15.12 ? 256  VAL B CA  1 ? 
ATOM   4334 C C   . VAL B 1 256 ? 26.985  33.537  -40.798 1.00 14.23 ? 256  VAL B C   1 ? 
ATOM   4335 O O   . VAL B 1 256 ? 27.205  32.742  -41.735 1.00 14.27 ? 256  VAL B O   1 ? 
ATOM   4336 C CB  . VAL B 1 256 ? 24.873  32.778  -39.635 1.00 14.82 ? 256  VAL B CB  1 ? 
ATOM   4337 C CG1 . VAL B 1 256 ? 25.628  32.493  -38.345 1.00 15.79 ? 256  VAL B CG1 1 ? 
ATOM   4338 C CG2 . VAL B 1 256 ? 23.412  33.102  -39.371 1.00 16.12 ? 256  VAL B CG2 1 ? 
ATOM   4339 N N   . GLN B 1 257 ? 27.938  34.081  -40.045 1.00 15.27 ? 257  GLN B N   1 ? 
ATOM   4340 C CA  . GLN B 1 257 ? 29.375  33.757  -40.160 1.00 16.71 ? 257  GLN B CA  1 ? 
ATOM   4341 C C   . GLN B 1 257 ? 29.603  32.413  -39.485 1.00 15.67 ? 257  GLN B C   1 ? 
ATOM   4342 O O   . GLN B 1 257 ? 29.417  32.347  -38.268 1.00 17.79 ? 257  GLN B O   1 ? 
ATOM   4343 C CB  . GLN B 1 257 ? 30.252  34.832  -39.514 1.00 19.44 ? 257  GLN B CB  1 ? 
ATOM   4344 C CG  . GLN B 1 257 ? 31.740  34.503  -39.498 1.00 25.51 ? 257  GLN B CG  1 ? 
ATOM   4345 C CD  . GLN B 1 257 ? 32.556  35.384  -38.569 1.00 31.20 ? 257  GLN B CD  1 ? 
ATOM   4346 O OE1 . GLN B 1 257 ? 33.423  34.918  -37.813 1.00 35.17 ? 257  GLN B OE1 1 ? 
ATOM   4347 N NE2 . GLN B 1 257 ? 32.264  36.674  -38.596 1.00 32.62 ? 257  GLN B NE2 1 ? 
ATOM   4348 N N   . VAL B 1 258 ? 29.896  31.378  -40.241 1.00 14.61 ? 258  VAL B N   1 ? 
ATOM   4349 C CA  . VAL B 1 258 ? 30.045  30.006  -39.702 1.00 14.16 ? 258  VAL B CA  1 ? 
ATOM   4350 C C   . VAL B 1 258 ? 31.490  29.567  -39.855 1.00 15.54 ? 258  VAL B C   1 ? 
ATOM   4351 O O   . VAL B 1 258 ? 32.076  29.673  -40.965 1.00 15.44 ? 258  VAL B O   1 ? 
ATOM   4352 C CB  . VAL B 1 258 ? 29.092  29.012  -40.385 1.00 14.65 ? 258  VAL B CB  1 ? 
ATOM   4353 C CG1 . VAL B 1 258 ? 29.325  27.609  -39.852 1.00 14.27 ? 258  VAL B CG1 1 ? 
ATOM   4354 C CG2 . VAL B 1 258 ? 27.650  29.467  -40.241 1.00 14.98 ? 258  VAL B CG2 1 ? 
ATOM   4355 N N   . THR B 1 259 ? 32.029  28.988  -38.798 1.00 13.68 ? 259  THR B N   1 ? 
ATOM   4356 C CA  . THR B 1 259 ? 33.296  28.243  -38.856 1.00 14.07 ? 259  THR B CA  1 ? 
ATOM   4357 C C   . THR B 1 259 ? 32.962  26.771  -38.659 1.00 14.74 ? 259  THR B C   1 ? 
ATOM   4358 O O   . THR B 1 259 ? 32.484  26.416  -37.581 1.00 15.15 ? 259  THR B O   1 ? 
ATOM   4359 C CB  . THR B 1 259 ? 34.283  28.783  -37.828 1.00 14.60 ? 259  THR B CB  1 ? 
ATOM   4360 O OG1 . THR B 1 259 ? 34.536  30.173  -38.083 1.00 15.38 ? 259  THR B OG1 1 ? 
ATOM   4361 C CG2 . THR B 1 259 ? 35.578  28.006  -37.841 1.00 15.51 ? 259  THR B CG2 1 ? 
ATOM   4362 N N   . LEU B 1 260 ? 33.078  25.978  -39.708 1.00 13.88 ? 260  LEU B N   1 ? 
ATOM   4363 C CA  . LEU B 1 260 ? 32.685  24.555  -39.675 1.00 14.11 ? 260  LEU B CA  1 ? 
ATOM   4364 C C   . LEU B 1 260 ? 33.972  23.747  -39.635 1.00 14.55 ? 260  LEU B C   1 ? 
ATOM   4365 O O   . LEU B 1 260 ? 34.745  23.807  -40.604 1.00 16.02 ? 260  LEU B O   1 ? 
ATOM   4366 C CB  . LEU B 1 260 ? 31.817  24.200  -40.884 1.00 14.46 ? 260  LEU B CB  1 ? 
ATOM   4367 C CG  . LEU B 1 260 ? 31.544  22.708  -41.052 1.00 14.87 ? 260  LEU B CG  1 ? 
ATOM   4368 C CD1 . LEU B 1 260 ? 30.716  22.192  -39.896 1.00 16.02 ? 260  LEU B CD1 1 ? 
ATOM   4369 C CD2 . LEU B 1 260 ? 30.811  22.427  -42.347 1.00 16.26 ? 260  LEU B CD2 1 ? 
ATOM   4370 N N   . GLU B 1 261 ? 34.206  23.023  -38.546 1.00 13.84 ? 261  GLU B N   1 ? 
ATOM   4371 C CA  . GLU B 1 261 ? 35.442  22.240  -38.351 1.00 14.65 ? 261  GLU B CA  1 ? 
ATOM   4372 C C   . GLU B 1 261 ? 35.091  20.767  -38.286 1.00 15.70 ? 261  GLU B C   1 ? 
ATOM   4373 O O   . GLU B 1 261 ? 34.690  20.270  -37.229 1.00 14.50 ? 261  GLU B O   1 ? 
ATOM   4374 C CB  . GLU B 1 261 ? 36.168  22.610  -37.062 1.00 15.86 ? 261  GLU B CB  1 ? 
ATOM   4375 C CG  . GLU B 1 261 ? 36.655  24.019  -37.058 1.00 17.07 ? 261  GLU B CG  1 ? 
ATOM   4376 C CD  . GLU B 1 261 ? 37.526  24.382  -35.870 1.00 17.66 ? 261  GLU B CD  1 ? 
ATOM   4377 O OE1 . GLU B 1 261 ? 37.619  23.571  -34.900 1.00 17.07 ? 261  GLU B OE1 1 ? 
ATOM   4378 O OE2 . GLU B 1 261 ? 38.093  25.506  -35.920 1.00 19.67 ? 261  GLU B OE2 1 ? 
ATOM   4379 N N   . PRO B 1 262 ? 35.213  20.013  -39.401 1.00 15.80 ? 262  PRO B N   1 ? 
ATOM   4380 C CA  . PRO B 1 262 ? 35.082  18.560  -39.364 1.00 15.81 ? 262  PRO B CA  1 ? 
ATOM   4381 C C   . PRO B 1 262 ? 36.433  17.940  -39.014 1.00 18.17 ? 262  PRO B C   1 ? 
ATOM   4382 O O   . PRO B 1 262 ? 37.352  17.932  -39.860 1.00 19.38 ? 262  PRO B O   1 ? 
ATOM   4383 C CB  . PRO B 1 262 ? 34.607  18.155  -40.762 1.00 17.34 ? 262  PRO B CB  1 ? 
ATOM   4384 C CG  . PRO B 1 262 ? 34.491  19.455  -41.503 1.00 17.88 ? 262  PRO B CG  1 ? 
ATOM   4385 C CD  . PRO B 1 262 ? 35.355  20.470  -40.784 1.00 17.00 ? 262  PRO B CD  1 ? 
ATOM   4386 N N   . TRP B 1 263 ? 36.542  17.432  -37.797 1.00 15.47 ? 263  TRP B N   1 ? 
ATOM   4387 C CA  . TRP B 1 263 ? 37.788  16.848  -37.267 1.00 15.88 ? 263  TRP B CA  1 ? 
ATOM   4388 C C   . TRP B 1 263 ? 37.885  15.388  -37.731 1.00 17.46 ? 263  TRP B C   1 ? 
ATOM   4389 O O   . TRP B 1 263 ? 37.019  14.556  -37.387 1.00 16.17 ? 263  TRP B O   1 ? 
ATOM   4390 C CB  . TRP B 1 263 ? 37.838  17.009  -35.749 1.00 15.46 ? 263  TRP B CB  1 ? 
ATOM   4391 C CG  . TRP B 1 263 ? 38.138  18.397  -35.283 1.00 15.91 ? 263  TRP B CG  1 ? 
ATOM   4392 C CD1 . TRP B 1 263 ? 37.407  19.534  -35.471 1.00 15.97 ? 263  TRP B CD1 1 ? 
ATOM   4393 C CD2 . TRP B 1 263 ? 39.261  18.788  -34.483 1.00 15.33 ? 263  TRP B CD2 1 ? 
ATOM   4394 N NE1 . TRP B 1 263 ? 38.017  20.607  -34.872 1.00 16.23 ? 263  TRP B NE1 1 ? 
ATOM   4395 C CE2 . TRP B 1 263 ? 39.150  20.171  -34.239 1.00 16.38 ? 263  TRP B CE2 1 ? 
ATOM   4396 C CE3 . TRP B 1 263 ? 40.329  18.083  -33.919 1.00 16.56 ? 263  TRP B CE3 1 ? 
ATOM   4397 C CZ2 . TRP B 1 263 ? 40.103  20.877  -33.507 1.00 16.76 ? 263  TRP B CZ2 1 ? 
ATOM   4398 C CZ3 . TRP B 1 263 ? 41.265  18.784  -33.188 1.00 16.69 ? 263  TRP B CZ3 1 ? 
ATOM   4399 C CH2 . TRP B 1 263 ? 41.154  20.153  -32.990 1.00 17.87 ? 263  TRP B CH2 1 ? 
ATOM   4400 N N   . GLU B 1 264 ? 38.921  15.082  -38.508 1.00 19.84 ? 264  GLU B N   1 ? 
ATOM   4401 C CA  . GLU B 1 264 ? 39.073  13.767  -39.166 1.00 21.03 ? 264  GLU B CA  1 ? 
ATOM   4402 C C   . GLU B 1 264 ? 39.105  12.669  -38.105 1.00 18.69 ? 264  GLU B C   1 ? 
ATOM   4403 O O   . GLU B 1 264 ? 39.862  12.786  -37.121 1.00 19.64 ? 264  GLU B O   1 ? 
ATOM   4404 C CB  . GLU B 1 264 ? 40.336  13.744  -40.029 1.00 26.43 ? 264  GLU B CB  1 ? 
ATOM   4405 C CG  . GLU B 1 264 ? 40.433  12.489  -40.875 1.00 32.08 ? 264  GLU B CG  1 ? 
ATOM   4406 C CD  . GLU B 1 264 ? 41.595  12.427  -41.853 1.00 39.02 ? 264  GLU B CD  1 ? 
ATOM   4407 O OE1 . GLU B 1 264 ? 41.828  11.326  -42.413 1.00 45.86 ? 264  GLU B OE1 1 ? 
ATOM   4408 O OE2 . GLU B 1 264 ? 42.274  13.465  -42.061 1.00 45.56 ? 264  GLU B OE2 1 ? 
ATOM   4409 N N   . ASP B 1 265 ? 38.248  11.679  -38.297 1.00 17.81 ? 265  ASP B N   1 ? 
ATOM   4410 C CA  . ASP B 1 265 ? 38.169  10.411  -37.541 1.00 19.25 ? 265  ASP B CA  1 ? 
ATOM   4411 C C   . ASP B 1 265 ? 37.527  10.631  -36.168 1.00 17.22 ? 265  ASP B C   1 ? 
ATOM   4412 O O   . ASP B 1 265 ? 37.336  9.648   -35.458 1.00 17.75 ? 265  ASP B O   1 ? 
ATOM   4413 C CB  . ASP B 1 265 ? 39.535  9.737   -37.397 1.00 21.71 ? 265  ASP B CB  1 ? 
ATOM   4414 C CG  . ASP B 1 265 ? 40.132  9.303   -38.723 1.00 26.49 ? 265  ASP B CG  1 ? 
ATOM   4415 O OD1 . ASP B 1 265 ? 39.380  8.760   -39.551 1.00 26.57 ? 265  ASP B OD1 1 ? 
ATOM   4416 O OD2 . ASP B 1 265 ? 41.338  9.552   -38.929 1.00 32.10 ? 265  ASP B OD2 1 ? 
ATOM   4417 N N   . MET B 1 266 ? 37.178  11.864  -35.797 1.00 16.41 ? 266  MET B N   1 ? 
ATOM   4418 C CA  . MET B 1 266 ? 36.631  12.082  -34.432 1.00 16.64 ? 266  MET B CA  1 ? 
ATOM   4419 C C   . MET B 1 266 ? 35.183  11.592  -34.351 1.00 16.70 ? 266  MET B C   1 ? 
ATOM   4420 O O   . MET B 1 266 ? 34.456  11.498  -35.359 1.00 16.45 ? 266  MET B O   1 ? 
ATOM   4421 C CB  . MET B 1 266 ? 36.732  13.534  -33.983 1.00 16.55 ? 266  MET B CB  1 ? 
ATOM   4422 C CG  . MET B 1 266 ? 38.158  13.973  -33.704 1.00 16.81 ? 266  MET B CG  1 ? 
ATOM   4423 S SD  . MET B 1 266 ? 38.963  12.947  -32.466 1.00 19.12 ? 266  MET B SD  1 ? 
ATOM   4424 C CE  . MET B 1 266 ? 40.036  11.986  -33.530 1.00 19.48 ? 266  MET B CE  1 ? 
ATOM   4425 N N   . ILE B 1 267 ? 34.796  11.258  -33.132 1.00 16.71 ? 267  ILE B N   1 ? 
ATOM   4426 C CA  . ILE B 1 267 ? 33.474  10.669  -32.811 1.00 17.20 ? 267  ILE B CA  1 ? 
ATOM   4427 C C   . ILE B 1 267 ? 32.646  11.703  -32.047 1.00 16.12 ? 267  ILE B C   1 ? 
ATOM   4428 O O   . ILE B 1 267 ? 33.129  12.806  -31.709 1.00 14.29 ? 267  ILE B O   1 ? 
ATOM   4429 C CB  . ILE B 1 267 ? 33.664  9.337   -32.058 1.00 20.56 ? 267  ILE B CB  1 ? 
ATOM   4430 C CG1 . ILE B 1 267 ? 34.541  9.460   -30.803 1.00 23.62 ? 267  ILE B CG1 1 ? 
ATOM   4431 C CG2 . ILE B 1 267 ? 34.232  8.304   -33.013 1.00 21.02 ? 267  ILE B CG2 1 ? 
ATOM   4432 C CD1 . ILE B 1 267 ? 33.886  10.094  -29.621 1.00 27.83 ? 267  ILE B CD1 1 ? 
ATOM   4433 N N   . HIS B 1 268 ? 31.397  11.346  -31.810 1.00 15.33 ? 268  HIS B N   1 ? 
ATOM   4434 C CA  . HIS B 1 268 ? 30.372  12.220  -31.202 1.00 14.57 ? 268  HIS B CA  1 ? 
ATOM   4435 C C   . HIS B 1 268 ? 30.858  12.840  -29.892 1.00 14.80 ? 268  HIS B C   1 ? 
ATOM   4436 O O   . HIS B 1 268 ? 31.180  12.104  -28.958 1.00 14.90 ? 268  HIS B O   1 ? 
ATOM   4437 C CB  . HIS B 1 268 ? 29.117  11.387  -31.002 1.00 13.87 ? 268  HIS B CB  1 ? 
ATOM   4438 C CG  . HIS B 1 268 ? 27.926  12.184  -30.627 1.00 14.40 ? 268  HIS B CG  1 ? 
ATOM   4439 N ND1 . HIS B 1 268 ? 27.462  13.211  -31.402 1.00 14.08 ? 268  HIS B ND1 1 ? 
ATOM   4440 C CD2 . HIS B 1 268 ? 27.139  12.126  -29.533 1.00 15.07 ? 268  HIS B CD2 1 ? 
ATOM   4441 C CE1 . HIS B 1 268 ? 26.374  13.710  -30.833 1.00 15.02 ? 268  HIS B CE1 1 ? 
ATOM   4442 N NE2 . HIS B 1 268 ? 26.163  13.067  -29.696 1.00 13.94 ? 268  HIS B NE2 1 ? 
ATOM   4443 N N   . VAL B 1 269 ? 30.880  14.171  -29.833 1.00 14.25 ? 269  VAL B N   1 ? 
ATOM   4444 C CA  . VAL B 1 269 ? 31.285  14.963  -28.639 1.00 13.99 ? 269  VAL B CA  1 ? 
ATOM   4445 C C   . VAL B 1 269 ? 32.605  14.396  -28.098 1.00 13.66 ? 269  VAL B C   1 ? 
ATOM   4446 O O   . VAL B 1 269 ? 32.775  14.246  -26.902 1.00 14.00 ? 269  VAL B O   1 ? 
ATOM   4447 C CB  . VAL B 1 269 ? 30.174  15.048  -27.578 1.00 14.31 ? 269  VAL B CB  1 ? 
ATOM   4448 C CG1 . VAL B 1 269 ? 30.464  16.198  -26.612 1.00 13.88 ? 269  VAL B CG1 1 ? 
ATOM   4449 C CG2 . VAL B 1 269 ? 28.799  15.224  -28.203 1.00 14.69 ? 269  VAL B CG2 1 ? 
ATOM   4450 N N   . TRP B 1 270 ? 33.572  14.203  -28.986 1.00 13.40 ? 270  TRP B N   1 ? 
ATOM   4451 C CA  . TRP B 1 270 ? 34.917  13.698  -28.610 1.00 13.07 ? 270  TRP B CA  1 ? 
ATOM   4452 C C   . TRP B 1 270 ? 35.567  14.645  -27.587 1.00 13.55 ? 270  TRP B C   1 ? 
ATOM   4453 O O   . TRP B 1 270 ? 36.411  14.179  -26.803 1.00 13.59 ? 270  TRP B O   1 ? 
ATOM   4454 C CB  . TRP B 1 270 ? 35.800  13.501  -29.838 1.00 12.92 ? 270  TRP B CB  1 ? 
ATOM   4455 C CG  . TRP B 1 270 ? 36.407  14.742  -30.404 1.00 13.02 ? 270  TRP B CG  1 ? 
ATOM   4456 C CD1 . TRP B 1 270 ? 37.662  15.220  -30.155 1.00 13.13 ? 270  TRP B CD1 1 ? 
ATOM   4457 C CD2 . TRP B 1 270 ? 35.810  15.660  -31.343 1.00 12.45 ? 270  TRP B CD2 1 ? 
ATOM   4458 N NE1 . TRP B 1 270 ? 37.879  16.369  -30.863 1.00 13.47 ? 270  TRP B NE1 1 ? 
ATOM   4459 C CE2 . TRP B 1 270 ? 36.760  16.664  -31.602 1.00 13.23 ? 270  TRP B CE2 1 ? 
ATOM   4460 C CE3 . TRP B 1 270 ? 34.573  15.731  -31.992 1.00 13.05 ? 270  TRP B CE3 1 ? 
ATOM   4461 C CZ2 . TRP B 1 270 ? 36.502  17.712  -32.491 1.00 13.45 ? 270  TRP B CZ2 1 ? 
ATOM   4462 C CZ3 . TRP B 1 270 ? 34.316  16.770  -32.853 1.00 13.14 ? 270  TRP B CZ3 1 ? 
ATOM   4463 C CH2 . TRP B 1 270 ? 35.290  17.723  -33.132 1.00 13.04 ? 270  TRP B CH2 1 ? 
ATOM   4464 N N   . GLN B 1 271 ? 35.183  15.916  -27.580 1.00 13.37 ? 271  GLN B N   1 ? 
ATOM   4465 C CA  . GLN B 1 271 ? 35.694  16.912  -26.599 1.00 13.76 ? 271  GLN B CA  1 ? 
ATOM   4466 C C   . GLN B 1 271 ? 35.457  16.422  -25.163 1.00 13.93 ? 271  GLN B C   1 ? 
ATOM   4467 O O   . GLN B 1 271 ? 36.259  16.767  -24.274 1.00 14.70 ? 271  GLN B O   1 ? 
ATOM   4468 C CB  . GLN B 1 271 ? 35.037  18.269  -26.833 1.00 13.86 ? 271  GLN B CB  1 ? 
ATOM   4469 C CG  . GLN B 1 271 ? 35.261  18.823  -28.234 1.00 14.33 ? 271  GLN B CG  1 ? 
ATOM   4470 C CD  . GLN B 1 271 ? 34.159  18.466  -29.200 1.00 14.39 ? 271  GLN B CD  1 ? 
ATOM   4471 O OE1 . GLN B 1 271 ? 33.427  17.503  -29.001 1.00 13.37 ? 271  GLN B OE1 1 ? 
ATOM   4472 N NE2 . GLN B 1 271 ? 33.989  19.277  -30.231 1.00 14.20 ? 271  GLN B NE2 1 ? 
ATOM   4473 N N   . ALA B 1 272 ? 34.375  15.687  -24.899 1.00 13.90 ? 272  ALA B N   1 ? 
ATOM   4474 C CA  . ALA B 1 272 ? 34.040  15.202  -23.544 1.00 14.26 ? 272  ALA B CA  1 ? 
ATOM   4475 C C   . ALA B 1 272 ? 35.093  14.194  -23.067 1.00 15.54 ? 272  ALA B C   1 ? 
ATOM   4476 O O   . ALA B 1 272 ? 35.146  13.945  -21.861 1.00 16.80 ? 272  ALA B O   1 ? 
ATOM   4477 C CB  . ALA B 1 272 ? 32.662  14.595  -23.538 1.00 14.68 ? 272  ALA B CB  1 ? 
ATOM   4478 N N   . PHE B 1 273 ? 35.898  13.636  -23.971 1.00 14.91 ? 273  PHE B N   1 ? 
ATOM   4479 C CA  . PHE B 1 273 ? 36.936  12.638  -23.641 1.00 15.67 ? 273  PHE B CA  1 ? 
ATOM   4480 C C   . PHE B 1 273 ? 38.322  13.283  -23.517 1.00 16.57 ? 273  PHE B C   1 ? 
ATOM   4481 O O   . PHE B 1 273 ? 39.293  12.542  -23.522 1.00 18.09 ? 273  PHE B O   1 ? 
ATOM   4482 C CB  . PHE B 1 273 ? 36.916  11.502  -24.670 1.00 16.54 ? 273  PHE B CB  1 ? 
ATOM   4483 C CG  . PHE B 1 273 ? 35.601  10.779  -24.717 1.00 17.51 ? 273  PHE B CG  1 ? 
ATOM   4484 C CD1 . PHE B 1 273 ? 35.344  9.723   -23.868 1.00 20.64 ? 273  PHE B CD1 1 ? 
ATOM   4485 C CD2 . PHE B 1 273 ? 34.598  11.210  -25.571 1.00 19.33 ? 273  PHE B CD2 1 ? 
ATOM   4486 C CE1 . PHE B 1 273 ? 34.112  9.087   -23.896 1.00 21.32 ? 273  PHE B CE1 1 ? 
ATOM   4487 C CE2 . PHE B 1 273 ? 33.372  10.565  -25.611 1.00 19.56 ? 273  PHE B CE2 1 ? 
ATOM   4488 C CZ  . PHE B 1 273 ? 33.134  9.515   -24.762 1.00 21.07 ? 273  PHE B CZ  1 ? 
ATOM   4489 N N   . ALA B 1 274 ? 38.412  14.603  -23.395 1.00 17.18 ? 274  ALA B N   1 ? 
ATOM   4490 C CA  . ALA B 1 274 ? 39.682  15.359  -23.417 1.00 18.51 ? 274  ALA B CA  1 ? 
ATOM   4491 C C   . ALA B 1 274 ? 40.651  14.888  -22.329 1.00 19.31 ? 274  ALA B C   1 ? 
ATOM   4492 O O   . ALA B 1 274 ? 41.852  15.061  -22.558 1.00 20.70 ? 274  ALA B O   1 ? 
ATOM   4493 C CB  . ALA B 1 274 ? 39.411  16.825  -23.270 1.00 19.32 ? 274  ALA B CB  1 ? 
ATOM   4494 N N   . ALA B 1 275 ? 40.173  14.352  -21.206 1.00 20.38 ? 275  ALA B N   1 ? 
ATOM   4495 C CA  . ALA B 1 275 ? 41.086  13.818  -20.156 1.00 23.78 ? 275  ALA B CA  1 ? 
ATOM   4496 C C   . ALA B 1 275 ? 42.002  12.736  -20.748 1.00 26.56 ? 275  ALA B C   1 ? 
ATOM   4497 O O   . ALA B 1 275 ? 43.196  12.679  -20.354 1.00 27.22 ? 275  ALA B O   1 ? 
ATOM   4498 C CB  . ALA B 1 275 ? 40.323  13.298  -18.975 1.00 23.30 ? 275  ALA B CB  1 ? 
ATOM   4499 N N   A MET B 1 276 ? 41.487  11.911  -21.668 0.50 24.97 ? 276  MET B N   1 ? 
ATOM   4500 N N   B MET B 1 276 ? 41.463  11.908  -21.657 0.50 25.48 ? 276  MET B N   1 ? 
ATOM   4501 C CA  A MET B 1 276 ? 42.211  10.724  -22.203 0.50 25.27 ? 276  MET B CA  1 ? 
ATOM   4502 C CA  B MET B 1 276 ? 42.136  10.705  -22.222 0.50 26.02 ? 276  MET B CA  1 ? 
ATOM   4503 C C   A MET B 1 276 ? 42.418  10.812  -23.722 0.50 23.73 ? 276  MET B C   1 ? 
ATOM   4504 C C   B MET B 1 276 ? 42.570  10.967  -23.674 0.50 24.51 ? 276  MET B C   1 ? 
ATOM   4505 O O   A MET B 1 276 ? 43.084  9.907   -24.245 0.50 23.53 ? 276  MET B O   1 ? 
ATOM   4506 O O   B MET B 1 276 ? 43.622  10.442  -24.079 0.50 25.41 ? 276  MET B O   1 ? 
ATOM   4507 C CB  A MET B 1 276 ? 41.478  9.418   -21.867 0.50 26.34 ? 276  MET B CB  1 ? 
ATOM   4508 C CB  B MET B 1 276 ? 41.201  9.489   -22.182 0.50 27.31 ? 276  MET B CB  1 ? 
ATOM   4509 C CG  A MET B 1 276 ? 40.016  9.393   -22.263 0.50 28.09 ? 276  MET B CG  1 ? 
ATOM   4510 C CG  B MET B 1 276 ? 40.380  9.366   -20.894 0.50 29.95 ? 276  MET B CG  1 ? 
ATOM   4511 S SD  A MET B 1 276 ? 39.224  7.831   -21.802 0.50 34.98 ? 276  MET B SD  1 ? 
ATOM   4512 S SD  B MET B 1 276 ? 38.770  10.215  -20.986 0.50 33.07 ? 276  MET B SD  1 ? 
ATOM   4513 C CE  A MET B 1 276 ? 38.852  8.106   -20.071 0.50 32.03 ? 276  MET B CE  1 ? 
ATOM   4514 C CE  B MET B 1 276 ? 38.025  9.697   -19.441 0.50 32.39 ? 276  MET B CE  1 ? 
ATOM   4515 N N   . LEU B 1 277 ? 41.823  11.792  -24.419 1.00 22.13 ? 277  LEU B N   1 ? 
ATOM   4516 C CA  . LEU B 1 277 ? 41.934  11.905  -25.898 1.00 21.30 ? 277  LEU B CA  1 ? 
ATOM   4517 C C   . LEU B 1 277 ? 42.593  13.230  -26.272 1.00 21.42 ? 277  LEU B C   1 ? 
ATOM   4518 O O   . LEU B 1 277 ? 41.998  14.297  -26.090 1.00 20.15 ? 277  LEU B O   1 ? 
ATOM   4519 C CB  . LEU B 1 277 ? 40.531  11.820  -26.504 1.00 20.81 ? 277  LEU B CB  1 ? 
ATOM   4520 C CG  . LEU B 1 277 ? 40.461  11.839  -28.024 1.00 20.21 ? 277  LEU B CG  1 ? 
ATOM   4521 C CD1 . LEU B 1 277 ? 41.111  10.578  -28.606 1.00 21.75 ? 277  LEU B CD1 1 ? 
ATOM   4522 C CD2 . LEU B 1 277 ? 39.010  11.957  -28.456 1.00 18.77 ? 277  LEU B CD2 1 ? 
ATOM   4523 N N   . PRO B 1 278 ? 43.846  13.216  -26.773 1.00 22.59 ? 278  PRO B N   1 ? 
ATOM   4524 C CA  . PRO B 1 278 ? 44.535  14.464  -27.114 1.00 23.62 ? 278  PRO B CA  1 ? 
ATOM   4525 C C   . PRO B 1 278 ? 43.729  15.398  -28.036 1.00 22.28 ? 278  PRO B C   1 ? 
ATOM   4526 O O   . PRO B 1 278 ? 43.717  16.601  -27.779 1.00 21.41 ? 278  PRO B O   1 ? 
ATOM   4527 C CB  . PRO B 1 278 ? 45.835  14.001  -27.779 1.00 25.23 ? 278  PRO B CB  1 ? 
ATOM   4528 C CG  . PRO B 1 278 ? 46.076  12.609  -27.216 1.00 25.46 ? 278  PRO B CG  1 ? 
ATOM   4529 C CD  . PRO B 1 278 ? 44.706  12.028  -26.934 1.00 24.31 ? 278  PRO B CD  1 ? 
ATOM   4530 N N   . GLU B 1 279 ? 43.048  14.829  -29.039 1.00 21.13 ? 279  GLU B N   1 ? 
ATOM   4531 C CA  . GLU B 1 279 ? 42.236  15.613  -30.008 1.00 20.27 ? 279  GLU B CA  1 ? 
ATOM   4532 C C   . GLU B 1 279 ? 41.078  16.300  -29.279 1.00 18.33 ? 279  GLU B C   1 ? 
ATOM   4533 O O   . GLU B 1 279 ? 40.629  17.344  -29.766 1.00 17.72 ? 279  GLU B O   1 ? 
ATOM   4534 C CB  . GLU B 1 279 ? 41.673  14.720  -31.112 1.00 21.94 ? 279  GLU B CB  1 ? 
ATOM   4535 C CG  . GLU B 1 279 ? 42.741  14.161  -32.041 1.00 24.21 ? 279  GLU B CG  1 ? 
ATOM   4536 C CD  . GLU B 1 279 ? 43.345  12.813  -31.670 1.00 25.54 ? 279  GLU B CD  1 ? 
ATOM   4537 O OE1 . GLU B 1 279 ? 43.270  12.408  -30.493 1.00 24.22 ? 279  GLU B OE1 1 ? 
ATOM   4538 O OE2 . GLU B 1 279 ? 43.914  12.172  -32.577 1.00 28.55 ? 279  GLU B OE2 1 ? 
ATOM   4539 N N   . GLY B 1 280 ? 40.597  15.718  -28.182 1.00 16.26 ? 280  GLY B N   1 ? 
ATOM   4540 C CA  . GLY B 1 280 ? 39.548  16.351  -27.361 1.00 16.60 ? 280  GLY B CA  1 ? 
ATOM   4541 C C   . GLY B 1 280 ? 40.051  17.653  -26.765 1.00 17.08 ? 280  GLY B C   1 ? 
ATOM   4542 O O   . GLY B 1 280 ? 39.351  18.688  -26.869 1.00 16.79 ? 280  GLY B O   1 ? 
ATOM   4543 N N   . GLN B 1 281 ? 41.244  17.615  -26.174 1.00 18.40 ? 281  GLN B N   1 ? 
ATOM   4544 C CA  . GLN B 1 281 ? 41.810  18.830  -25.532 1.00 19.03 ? 281  GLN B CA  1 ? 
ATOM   4545 C C   . GLN B 1 281 ? 42.165  19.829  -26.642 1.00 18.23 ? 281  GLN B C   1 ? 
ATOM   4546 O O   . GLN B 1 281 ? 41.910  21.027  -26.446 1.00 19.82 ? 281  GLN B O   1 ? 
ATOM   4547 C CB  . GLN B 1 281 ? 42.976  18.477  -24.610 1.00 22.70 ? 281  GLN B CB  1 ? 
ATOM   4548 C CG  . GLN B 1 281 ? 43.359  19.600  -23.635 1.00 24.61 ? 281  GLN B CG  1 ? 
ATOM   4549 C CD  . GLN B 1 281 ? 42.227  20.349  -22.954 1.00 26.58 ? 281  GLN B CD  1 ? 
ATOM   4550 O OE1 . GLN B 1 281 ? 41.334  19.786  -22.315 1.00 31.34 ? 281  GLN B OE1 1 ? 
ATOM   4551 N NE2 . GLN B 1 281 ? 42.262  21.670  -23.052 1.00 28.86 ? 281  GLN B NE2 1 ? 
ATOM   4552 N N   . GLN B 1 282 ? 42.691  19.381  -27.771 1.00 17.37 ? 282  GLN B N   1 ? 
ATOM   4553 C CA  . GLN B 1 282 ? 43.018  20.294  -28.900 1.00 18.18 ? 282  GLN B CA  1 ? 
ATOM   4554 C C   . GLN B 1 282 ? 41.751  21.031  -29.373 1.00 18.44 ? 282  GLN B C   1 ? 
ATOM   4555 O O   . GLN B 1 282 ? 41.800  22.260  -29.630 1.00 17.08 ? 282  GLN B O   1 ? 
ATOM   4556 C CB  . GLN B 1 282 ? 43.636  19.536  -30.067 1.00 20.59 ? 282  GLN B CB  1 ? 
ATOM   4557 C CG  . GLN B 1 282 ? 45.009  18.942  -29.769 1.00 21.22 ? 282  GLN B CG  1 ? 
ATOM   4558 C CD  . GLN B 1 282 ? 45.316  17.806  -30.718 1.00 24.17 ? 282  GLN B CD  1 ? 
ATOM   4559 O OE1 . GLN B 1 282 ? 44.861  17.789  -31.866 1.00 27.29 ? 282  GLN B OE1 1 ? 
ATOM   4560 N NE2 . GLN B 1 282 ? 46.095  16.836  -30.252 1.00 27.11 ? 282  GLN B NE2 1 ? 
ATOM   4561 N N   . ALA B 1 283 ? 40.627  20.315  -29.512 1.00 16.80 ? 283  ALA B N   1 ? 
ATOM   4562 C CA  . ALA B 1 283 ? 39.367  20.940  -29.973 1.00 16.00 ? 283  ALA B CA  1 ? 
ATOM   4563 C C   . ALA B 1 283 ? 38.867  21.949  -28.930 1.00 15.87 ? 283  ALA B C   1 ? 
ATOM   4564 O O   . ALA B 1 283 ? 38.375  23.015  -29.326 1.00 14.94 ? 283  ALA B O   1 ? 
ATOM   4565 C CB  . ALA B 1 283 ? 38.328  19.887  -30.267 1.00 16.40 ? 283  ALA B CB  1 ? 
ATOM   4566 N N   . ILE B 1 284 ? 39.002  21.644  -27.634 1.00 14.69 ? 284  ILE B N   1 ? 
ATOM   4567 C CA  . ILE B 1 284 ? 38.569  22.586  -26.572 1.00 15.35 ? 284  ILE B CA  1 ? 
ATOM   4568 C C   . ILE B 1 284 ? 39.448  23.837  -26.621 1.00 15.75 ? 284  ILE B C   1 ? 
ATOM   4569 O O   . ILE B 1 284 ? 38.911  24.940  -26.451 1.00 14.99 ? 284  ILE B O   1 ? 
ATOM   4570 C CB  . ILE B 1 284 ? 38.569  21.914  -25.192 1.00 15.87 ? 284  ILE B CB  1 ? 
ATOM   4571 C CG1 . ILE B 1 284 ? 37.474  20.845  -25.143 1.00 15.64 ? 284  ILE B CG1 1 ? 
ATOM   4572 C CG2 . ILE B 1 284 ? 38.368  22.959  -24.094 1.00 17.37 ? 284  ILE B CG2 1 ? 
ATOM   4573 C CD1 . ILE B 1 284 ? 37.486  19.975  -23.920 1.00 16.33 ? 284  ILE B CD1 1 ? 
ATOM   4574 N N   A GLU B 1 285 ? 40.756  23.684  -26.850 0.50 16.96 ? 285  GLU B N   1 ? 
ATOM   4575 N N   B GLU B 1 285 ? 40.752  23.688  -26.850 0.50 16.99 ? 285  GLU B N   1 ? 
ATOM   4576 C CA  A GLU B 1 285 ? 41.647  24.867  -26.991 0.50 18.96 ? 285  GLU B CA  1 ? 
ATOM   4577 C CA  B GLU B 1 285 ? 41.640  24.875  -26.985 0.50 19.01 ? 285  GLU B CA  1 ? 
ATOM   4578 C C   A GLU B 1 285 ? 41.131  25.739  -28.146 0.50 17.68 ? 285  GLU B C   1 ? 
ATOM   4579 C C   B GLU B 1 285 ? 41.144  25.741  -28.154 0.50 17.70 ? 285  GLU B C   1 ? 
ATOM   4580 O O   A GLU B 1 285 ? 41.089  26.976  -27.984 0.50 18.00 ? 285  GLU B O   1 ? 
ATOM   4581 O O   B GLU B 1 285 ? 41.118  26.981  -28.018 0.50 18.00 ? 285  GLU B O   1 ? 
ATOM   4582 C CB  A GLU B 1 285 ? 43.099  24.437  -27.181 0.50 20.84 ? 285  GLU B CB  1 ? 
ATOM   4583 C CB  B GLU B 1 285 ? 43.092  24.435  -27.134 0.50 20.92 ? 285  GLU B CB  1 ? 
ATOM   4584 C CG  A GLU B 1 285 ? 43.690  23.791  -25.948 0.50 22.97 ? 285  GLU B CG  1 ? 
ATOM   4585 C CG  B GLU B 1 285 ? 43.670  23.859  -25.858 0.50 23.25 ? 285  GLU B CG  1 ? 
ATOM   4586 C CD  A GLU B 1 285 ? 43.729  24.689  -24.726 0.50 24.75 ? 285  GLU B CD  1 ? 
ATOM   4587 C CD  B GLU B 1 285 ? 45.162  23.596  -25.949 0.50 24.88 ? 285  GLU B CD  1 ? 
ATOM   4588 O OE1 A GLU B 1 285 ? 43.816  24.147  -23.600 0.50 27.29 ? 285  GLU B OE1 1 ? 
ATOM   4589 O OE1 B GLU B 1 285 ? 45.775  24.073  -26.923 0.50 28.80 ? 285  GLU B OE1 1 ? 
ATOM   4590 O OE2 A GLU B 1 285 ? 43.688  25.933  -24.903 0.50 26.92 ? 285  GLU B OE2 1 ? 
ATOM   4591 O OE2 B GLU B 1 285 ? 45.701  22.910  -25.060 0.50 27.93 ? 285  GLU B OE2 1 ? 
ATOM   4592 N N   . ARG B 1 286 ? 40.689  25.116  -29.241 1.00 17.64 ? 286  ARG B N   1 ? 
ATOM   4593 C CA  . ARG B 1 286 ? 40.121  25.846  -30.406 1.00 18.17 ? 286  ARG B CA  1 ? 
ATOM   4594 C C   . ARG B 1 286 ? 38.826  26.578  -30.010 1.00 16.04 ? 286  ARG B C   1 ? 
ATOM   4595 O O   . ARG B 1 286 ? 38.625  27.735  -30.386 1.00 16.56 ? 286  ARG B O   1 ? 
ATOM   4596 C CB  . ARG B 1 286 ? 39.871  24.897  -31.582 1.00 21.35 ? 286  ARG B CB  1 ? 
ATOM   4597 C CG  . ARG B 1 286 ? 40.824  25.046  -32.762 1.00 24.39 ? 286  ARG B CG  1 ? 
ATOM   4598 C CD  . ARG B 1 286 ? 40.917  26.472  -33.297 1.00 24.53 ? 286  ARG B CD  1 ? 
ATOM   4599 N NE  . ARG B 1 286 ? 39.756  26.857  -34.092 1.00 23.62 ? 286  ARG B NE  1 ? 
ATOM   4600 C CZ  . ARG B 1 286 ? 39.296  28.089  -34.261 1.00 24.36 ? 286  ARG B CZ  1 ? 
ATOM   4601 N NH1 . ARG B 1 286 ? 39.884  29.144  -33.700 1.00 25.15 ? 286  ARG B NH1 1 ? 
ATOM   4602 N NH2 . ARG B 1 286 ? 38.243  28.276  -35.034 1.00 24.47 ? 286  ARG B NH2 1 ? 
ATOM   4603 N N   . ILE B 1 287 ? 37.948  25.937  -29.243 1.00 15.66 ? 287  ILE B N   1 ? 
ATOM   4604 C CA  . ILE B 1 287 ? 36.726  26.601  -28.731 1.00 14.26 ? 287  ILE B CA  1 ? 
ATOM   4605 C C   . ILE B 1 287 ? 37.131  27.865  -27.961 1.00 14.08 ? 287  ILE B C   1 ? 
ATOM   4606 O O   . ILE B 1 287 ? 36.511  28.910  -28.170 1.00 15.17 ? 287  ILE B O   1 ? 
ATOM   4607 C CB  . ILE B 1 287 ? 35.888  25.645  -27.854 1.00 13.88 ? 287  ILE B CB  1 ? 
ATOM   4608 C CG1 . ILE B 1 287 ? 35.348  24.456  -28.663 1.00 14.08 ? 287  ILE B CG1 1 ? 
ATOM   4609 C CG2 . ILE B 1 287 ? 34.781  26.428  -27.197 1.00 14.67 ? 287  ILE B CG2 1 ? 
ATOM   4610 C CD1 . ILE B 1 287 ? 34.767  23.345  -27.792 1.00 14.42 ? 287  ILE B CD1 1 ? 
ATOM   4611 N N   . GLY B 1 288 ? 38.107  27.759  -27.056 1.00 15.15 ? 288  GLY B N   1 ? 
ATOM   4612 C CA  . GLY B 1 288 ? 38.542  28.915  -26.248 1.00 15.52 ? 288  GLY B CA  1 ? 
ATOM   4613 C C   . GLY B 1 288 ? 39.082  30.020  -27.136 1.00 15.50 ? 288  GLY B C   1 ? 
ATOM   4614 O O   . GLY B 1 288 ? 38.757  31.202  -26.900 1.00 16.58 ? 288  GLY B O   1 ? 
ATOM   4615 N N   . GLU B 1 289 ? 39.858  29.660  -28.145 1.00 17.22 ? 289  GLU B N   1 ? 
ATOM   4616 C CA  . GLU B 1 289 ? 40.455  30.645  -29.088 1.00 18.62 ? 289  GLU B CA  1 ? 
ATOM   4617 C C   . GLU B 1 289 ? 39.340  31.371  -29.840 1.00 18.10 ? 289  GLU B C   1 ? 
ATOM   4618 O O   . GLU B 1 289 ? 39.378  32.596  -29.966 1.00 18.89 ? 289  GLU B O   1 ? 
ATOM   4619 C CB  . GLU B 1 289 ? 41.412  29.920  -30.029 1.00 21.33 ? 289  GLU B CB  1 ? 
ATOM   4620 C CG  . GLU B 1 289 ? 42.097  30.833  -31.017 1.00 26.09 ? 289  GLU B CG  1 ? 
ATOM   4621 C CD  . GLU B 1 289 ? 43.043  30.080  -31.942 1.00 30.79 ? 289  GLU B CD  1 ? 
ATOM   4622 O OE1 . GLU B 1 289 ? 42.596  29.099  -32.603 1.00 29.76 ? 289  GLU B OE1 1 ? 
ATOM   4623 O OE2 . GLU B 1 289 ? 44.238  30.451  -31.982 1.00 38.19 ? 289  GLU B OE2 1 ? 
ATOM   4624 N N   . PHE B 1 290 ? 38.348  30.625  -30.324 1.00 16.65 ? 290  PHE B N   1 ? 
ATOM   4625 C CA  . PHE B 1 290 ? 37.189  31.181  -31.056 1.00 16.17 ? 290  PHE B CA  1 ? 
ATOM   4626 C C   . PHE B 1 290 ? 36.446  32.177  -30.166 1.00 15.69 ? 290  PHE B C   1 ? 
ATOM   4627 O O   . PHE B 1 290 ? 36.096  33.287  -30.609 1.00 16.12 ? 290  PHE B O   1 ? 
ATOM   4628 C CB  . PHE B 1 290 ? 36.264  30.048  -31.518 1.00 15.25 ? 290  PHE B CB  1 ? 
ATOM   4629 C CG  . PHE B 1 290 ? 34.987  30.510  -32.162 1.00 15.65 ? 290  PHE B CG  1 ? 
ATOM   4630 C CD1 . PHE B 1 290 ? 34.950  30.826  -33.513 1.00 17.60 ? 290  PHE B CD1 1 ? 
ATOM   4631 C CD2 . PHE B 1 290 ? 33.807  30.584  -31.430 1.00 15.91 ? 290  PHE B CD2 1 ? 
ATOM   4632 C CE1 . PHE B 1 290 ? 33.771  31.249  -34.106 1.00 17.40 ? 290  PHE B CE1 1 ? 
ATOM   4633 C CE2 . PHE B 1 290 ? 32.637  31.033  -32.022 1.00 16.72 ? 290  PHE B CE2 1 ? 
ATOM   4634 C CZ  . PHE B 1 290 ? 32.624  31.373  -33.359 1.00 17.14 ? 290  PHE B CZ  1 ? 
ATOM   4635 N N   . LEU B 1 291 ? 36.151  31.802  -28.919 1.00 14.44 ? 291  LEU B N   1 ? 
ATOM   4636 C CA  . LEU B 1 291 ? 35.384  32.695  -28.030 1.00 15.19 ? 291  LEU B CA  1 ? 
ATOM   4637 C C   . LEU B 1 291 ? 36.204  33.941  -27.710 1.00 17.20 ? 291  LEU B C   1 ? 
ATOM   4638 O O   . LEU B 1 291 ? 35.644  35.012  -27.808 1.00 18.11 ? 291  LEU B O   1 ? 
ATOM   4639 C CB  . LEU B 1 291 ? 34.999  31.952  -26.757 1.00 15.86 ? 291  LEU B CB  1 ? 
ATOM   4640 C CG  . LEU B 1 291 ? 33.964  30.855  -26.975 1.00 16.15 ? 291  LEU B CG  1 ? 
ATOM   4641 C CD1 . LEU B 1 291 ? 33.757  30.100  -25.676 1.00 16.27 ? 291  LEU B CD1 1 ? 
ATOM   4642 C CD2 . LEU B 1 291 ? 32.661  31.424  -27.492 1.00 16.47 ? 291  LEU B CD2 1 ? 
ATOM   4643 N N   . ARG B 1 292 ? 37.479  33.771  -27.389 1.00 18.32 ? 292  ARG B N   1 ? 
ATOM   4644 C CA  . ARG B 1 292 ? 38.343  34.925  -27.032 1.00 20.14 ? 292  ARG B CA  1 ? 
ATOM   4645 C C   . ARG B 1 292 ? 38.442  35.875  -28.221 1.00 20.91 ? 292  ARG B C   1 ? 
ATOM   4646 O O   . ARG B 1 292 ? 38.408  37.101  -27.968 1.00 22.76 ? 292  ARG B O   1 ? 
ATOM   4647 C CB  . ARG B 1 292 ? 39.669  34.452  -26.461 1.00 21.76 ? 292  ARG B CB  1 ? 
ATOM   4648 C CG  . ARG B 1 292 ? 39.470  33.948  -25.038 1.00 23.35 ? 292  ARG B CG  1 ? 
ATOM   4649 C CD  . ARG B 1 292 ? 40.747  33.631  -24.314 1.00 26.67 ? 292  ARG B CD  1 ? 
ATOM   4650 N NE  . ARG B 1 292 ? 41.238  32.334  -24.727 1.00 28.74 ? 292  ARG B NE  1 ? 
ATOM   4651 C CZ  . ARG B 1 292 ? 42.170  32.127  -25.657 1.00 29.12 ? 292  ARG B CZ  1 ? 
ATOM   4652 N NH1 . ARG B 1 292 ? 42.763  33.144  -26.265 1.00 30.80 ? 292  ARG B NH1 1 ? 
ATOM   4653 N NH2 . ARG B 1 292 ? 42.528  30.895  -25.956 1.00 29.24 ? 292  ARG B NH2 1 ? 
ATOM   4654 N N   A GLN B 1 293 ? 38.539  35.357  -29.448 0.50 21.67 ? 293  GLN B N   1 ? 
ATOM   4655 N N   B GLN B 1 293 ? 38.500  35.323  -29.440 0.50 21.16 ? 293  GLN B N   1 ? 
ATOM   4656 C CA  A GLN B 1 293 ? 38.575  36.195  -30.681 0.50 23.81 ? 293  GLN B CA  1 ? 
ATOM   4657 C CA  B GLN B 1 293 ? 38.580  36.068  -30.731 0.50 23.10 ? 293  GLN B CA  1 ? 
ATOM   4658 C C   A GLN B 1 293 ? 37.327  37.085  -30.729 0.50 22.60 ? 293  GLN B C   1 ? 
ATOM   4659 C C   B GLN B 1 293 ? 37.325  36.916  -30.974 0.50 22.94 ? 293  GLN B C   1 ? 
ATOM   4660 O O   A GLN B 1 293 ? 37.444  38.296  -31.019 0.50 20.27 ? 293  GLN B O   1 ? 
ATOM   4661 O O   B GLN B 1 293 ? 37.451  37.920  -31.705 0.50 24.08 ? 293  GLN B O   1 ? 
ATOM   4662 C CB  A GLN B 1 293 ? 38.642  35.337  -31.944 0.50 26.65 ? 293  GLN B CB  1 ? 
ATOM   4663 C CB  B GLN B 1 293 ? 38.785  35.106  -31.900 0.50 24.59 ? 293  GLN B CB  1 ? 
ATOM   4664 C CG  A GLN B 1 293 ? 38.756  36.156  -33.220 0.50 29.88 ? 293  GLN B CG  1 ? 
ATOM   4665 C CG  B GLN B 1 293 ? 40.245  34.767  -32.152 0.50 26.52 ? 293  GLN B CG  1 ? 
ATOM   4666 C CD  A GLN B 1 293 ? 37.902  35.630  -34.348 0.50 32.38 ? 293  GLN B CD  1 ? 
ATOM   4667 C CD  B GLN B 1 293 ? 40.418  33.639  -33.138 0.50 27.04 ? 293  GLN B CD  1 ? 
ATOM   4668 O OE1 A GLN B 1 293 ? 37.726  34.426  -34.531 0.50 36.59 ? 293  GLN B OE1 1 ? 
ATOM   4669 O OE1 B GLN B 1 293 ? 39.459  32.992  -33.554 0.50 33.71 ? 293  GLN B OE1 1 ? 
ATOM   4670 N NE2 A GLN B 1 293 ? 37.353  36.551  -35.115 0.50 34.45 ? 293  GLN B NE2 1 ? 
ATOM   4671 N NE2 B GLN B 1 293 ? 41.657  33.391  -33.522 0.50 26.24 ? 293  GLN B NE2 1 ? 
ATOM   4672 N N   . HIS B 1 294 ? 36.160  36.518  -30.441 1.00 21.95 ? 294  HIS B N   1 ? 
ATOM   4673 C CA  . HIS B 1 294 ? 34.873  37.225  -30.630 1.00 21.58 ? 294  HIS B CA  1 ? 
ATOM   4674 C C   . HIS B 1 294 ? 34.553  38.124  -29.441 1.00 23.35 ? 294  HIS B C   1 ? 
ATOM   4675 O O   . HIS B 1 294 ? 33.656  38.961  -29.597 1.00 24.85 ? 294  HIS B O   1 ? 
ATOM   4676 C CB  . HIS B 1 294 ? 33.745  36.232  -30.940 1.00 21.63 ? 294  HIS B CB  1 ? 
ATOM   4677 C CG  . HIS B 1 294 ? 33.814  35.764  -32.345 1.00 21.17 ? 294  HIS B CG  1 ? 
ATOM   4678 N ND1 . HIS B 1 294 ? 34.474  34.617  -32.704 1.00 22.46 ? 294  HIS B ND1 1 ? 
ATOM   4679 C CD2 . HIS B 1 294 ? 33.435  36.356  -33.498 1.00 21.28 ? 294  HIS B CD2 1 ? 
ATOM   4680 C CE1 . HIS B 1 294 ? 34.421  34.471  -34.018 1.00 21.45 ? 294  HIS B CE1 1 ? 
ATOM   4681 N NE2 . HIS B 1 294 ? 33.807  35.525  -34.518 1.00 22.57 ? 294  HIS B NE2 1 ? 
ATOM   4682 N N   . TRP B 1 295 ? 35.240  37.956  -28.311 1.00 23.27 ? 295  TRP B N   1 ? 
ATOM   4683 C CA  . TRP B 1 295 ? 35.054  38.802  -27.107 1.00 26.01 ? 295  TRP B CA  1 ? 
ATOM   4684 C C   . TRP B 1 295 ? 35.979  40.025  -27.164 1.00 33.40 ? 295  TRP B C   1 ? 
ATOM   4685 O O   . TRP B 1 295 ? 37.070  39.927  -27.738 1.00 34.72 ? 295  TRP B O   1 ? 
ATOM   4686 C CB  . TRP B 1 295 ? 35.267  37.980  -25.835 1.00 21.60 ? 295  TRP B CB  1 ? 
ATOM   4687 C CG  . TRP B 1 295 ? 34.122  37.055  -25.553 1.00 19.45 ? 295  TRP B CG  1 ? 
ATOM   4688 C CD1 . TRP B 1 295 ? 32.822  37.183  -25.944 1.00 19.00 ? 295  TRP B CD1 1 ? 
ATOM   4689 C CD2 . TRP B 1 295 ? 34.176  35.873  -24.744 1.00 17.74 ? 295  TRP B CD2 1 ? 
ATOM   4690 N NE1 . TRP B 1 295 ? 32.066  36.160  -25.444 1.00 19.93 ? 295  TRP B NE1 1 ? 
ATOM   4691 C CE2 . TRP B 1 295 ? 32.878  35.320  -24.733 1.00 17.36 ? 295  TRP B CE2 1 ? 
ATOM   4692 C CE3 . TRP B 1 295 ? 35.211  35.196  -24.092 1.00 18.35 ? 295  TRP B CE3 1 ? 
ATOM   4693 C CZ2 . TRP B 1 295 ? 32.589  34.153  -24.028 1.00 16.52 ? 295  TRP B CZ2 1 ? 
ATOM   4694 C CZ3 . TRP B 1 295 ? 34.922  34.038  -23.407 1.00 16.77 ? 295  TRP B CZ3 1 ? 
ATOM   4695 C CH2 . TRP B 1 295 ? 33.623  33.541  -23.362 1.00 16.31 ? 295  TRP B CH2 1 ? 
ATOM   4696 N N   . GLN B 1 296 ? 35.510  41.123  -26.584 1.00 43.90 ? 296  GLN B N   1 ? 
ATOM   4697 C CA  . GLN B 1 296 ? 36.170  42.451  -26.574 1.00 56.24 ? 296  GLN B CA  1 ? 
ATOM   4698 C C   . GLN B 1 296 ? 35.299  43.372  -25.713 1.00 63.24 ? 296  GLN B C   1 ? 
ATOM   4699 O O   . GLN B 1 296 ? 34.155  43.002  -25.399 1.00 63.31 ? 296  GLN B O   1 ? 
ATOM   4700 C CB  . GLN B 1 296 ? 36.324  42.981  -28.002 1.00 62.64 ? 296  GLN B CB  1 ? 
ATOM   4701 C CG  . GLN B 1 296 ? 37.626  43.725  -28.248 1.00 66.24 ? 296  GLN B CG  1 ? 
ATOM   4702 C CD  . GLN B 1 296 ? 37.705  44.213  -29.673 1.00 70.16 ? 296  GLN B CD  1 ? 
ATOM   4703 O OE1 . GLN B 1 296 ? 36.869  44.992  -30.129 1.00 69.76 ? 296  GLN B OE1 1 ? 
ATOM   4704 N NE2 . GLN B 1 296 ? 38.715  43.754  -30.394 1.00 71.90 ? 296  GLN B NE2 1 ? 
ATOM   4705 O OXT . GLN B 1 296 ? 35.715  44.463  -25.331 1.00 67.96 ? 296  GLN B OXT 1 ? 
HETATM 4706 C C   . FMT C 2 .   ? 16.262  8.905   -0.787  1.00 46.11 ? 1301 FMT A C   1 ? 
HETATM 4707 O O1  . FMT C 2 .   ? 15.681  8.034   -0.169  1.00 38.75 ? 1301 FMT A O1  1 ? 
HETATM 4708 O O2  . FMT C 2 .   ? 17.551  8.946   -1.001  1.00 46.31 ? 1301 FMT A O2  1 ? 
HETATM 4709 C C   . FMT D 2 .   ? 8.446   15.283  -6.495  1.00 63.43 ? 1302 FMT A C   1 ? 
HETATM 4710 O O1  . FMT D 2 .   ? 7.508   15.186  -7.259  1.00 61.64 ? 1302 FMT A O1  1 ? 
HETATM 4711 O O2  . FMT D 2 .   ? 8.576   14.610  -5.390  1.00 63.09 ? 1302 FMT A O2  1 ? 
HETATM 4712 C C   . FMT E 2 .   ? 11.293  14.292  -8.345  1.00 52.71 ? 1303 FMT A C   1 ? 
HETATM 4713 O O1  . FMT E 2 .   ? 10.189  14.192  -8.840  1.00 54.72 ? 1303 FMT A O1  1 ? 
HETATM 4714 O O2  . FMT E 2 .   ? 12.255  13.432  -8.492  1.00 46.49 ? 1303 FMT A O2  1 ? 
HETATM 4715 C C   . FMT F 2 .   ? 24.435  -7.197  -18.893 1.00 40.03 ? 1304 FMT A C   1 ? 
HETATM 4716 O O1  . FMT F 2 .   ? 24.157  -6.649  -17.843 1.00 42.84 ? 1304 FMT A O1  1 ? 
HETATM 4717 O O2  . FMT F 2 .   ? 24.771  -6.594  -19.996 1.00 44.24 ? 1304 FMT A O2  1 ? 
HETATM 4718 C C   . FMT G 2 .   ? -1.794  -2.187  10.191  1.00 35.19 ? 1305 FMT A C   1 ? 
HETATM 4719 O O1  . FMT G 2 .   ? -0.659  -2.607  10.296  1.00 30.90 ? 1305 FMT A O1  1 ? 
HETATM 4720 O O2  . FMT G 2 .   ? -2.112  -0.965  9.857   1.00 36.29 ? 1305 FMT A O2  1 ? 
HETATM 4721 C C   . FMT H 2 .   ? 12.460  -9.643  -31.400 1.00 26.26 ? 1306 FMT A C   1 ? 
HETATM 4722 O O1  . FMT H 2 .   ? 11.807  -8.717  -31.840 1.00 29.66 ? 1306 FMT A O1  1 ? 
HETATM 4723 O O2  . FMT H 2 .   ? 11.972  -10.813 -31.129 1.00 22.71 ? 1306 FMT A O2  1 ? 
HETATM 4724 C C   . ACT I 3 .   ? 4.884   -10.841 -18.036 1.00 23.33 ? 1307 ACT A C   1 ? 
HETATM 4725 O O   . ACT I 3 .   ? 4.980   -11.958 -18.641 1.00 30.91 ? 1307 ACT A O   1 ? 
HETATM 4726 O OXT . ACT I 3 .   ? 5.775   -10.341 -17.339 1.00 16.49 ? 1307 ACT A OXT 1 ? 
HETATM 4727 C CH3 . ACT I 3 .   ? 3.614   -10.042 -18.163 1.00 21.89 ? 1307 ACT A CH3 1 ? 
HETATM 4728 C C   . FMT J 2 .   ? 9.636   10.080  -0.718  1.00 49.67 ? 1308 FMT A C   1 ? 
HETATM 4729 O O1  . FMT J 2 .   ? 9.498   9.232   0.139   1.00 48.26 ? 1308 FMT A O1  1 ? 
HETATM 4730 O O2  . FMT J 2 .   ? 10.783  10.512  -1.166  1.00 50.39 ? 1308 FMT A O2  1 ? 
HETATM 4731 C C   . FMT K 2 .   ? 4.003   -3.351  14.510  1.00 46.55 ? 1309 FMT A C   1 ? 
HETATM 4732 O O1  . FMT K 2 .   ? 3.298   -2.510  13.986  1.00 45.26 ? 1309 FMT A O1  1 ? 
HETATM 4733 O O2  . FMT K 2 .   ? 4.194   -3.478  15.797  1.00 43.93 ? 1309 FMT A O2  1 ? 
HETATM 4734 C C   . FMT L 2 .   ? -7.392  -13.638 5.297   1.00 47.60 ? 1310 FMT A C   1 ? 
HETATM 4735 O O1  . FMT L 2 .   ? -7.162  -14.110 6.392   1.00 46.03 ? 1310 FMT A O1  1 ? 
HETATM 4736 O O2  . FMT L 2 .   ? -8.331  -12.776 5.035   1.00 48.89 ? 1310 FMT A O2  1 ? 
HETATM 4737 C C   . FMT M 2 .   ? -7.235  -23.442 -9.771  1.00 52.53 ? 1311 FMT A C   1 ? 
HETATM 4738 O O1  . FMT M 2 .   ? -6.701  -22.708 -8.964  1.00 51.68 ? 1311 FMT A O1  1 ? 
HETATM 4739 O O2  . FMT M 2 .   ? -6.633  -24.400 -10.420 1.00 48.15 ? 1311 FMT A O2  1 ? 
HETATM 4740 C C   . FMT N 2 .   ? 6.284   10.942  -18.419 1.00 50.03 ? 1312 FMT A C   1 ? 
HETATM 4741 O O1  . FMT N 2 .   ? 5.242   10.377  -18.682 1.00 50.87 ? 1312 FMT A O1  1 ? 
HETATM 4742 O O2  . FMT N 2 .   ? 7.026   10.689  -17.381 1.00 47.79 ? 1312 FMT A O2  1 ? 
HETATM 4743 C C   . FMT O 2 .   ? 11.486  -21.753 7.769   1.00 40.39 ? 1313 FMT A C   1 ? 
HETATM 4744 O O1  . FMT O 2 .   ? 11.547  -22.969 7.794   1.00 43.59 ? 1313 FMT A O1  1 ? 
HETATM 4745 O O2  . FMT O 2 .   ? 12.091  -20.912 8.572   1.00 36.04 ? 1313 FMT A O2  1 ? 
HETATM 4746 C C   . FMT P 2 .   ? 25.410  -24.284 -26.162 1.00 38.15 ? 1314 FMT A C   1 ? 
HETATM 4747 O O1  . FMT P 2 .   ? 25.334  -25.491 -26.234 1.00 31.97 ? 1314 FMT A O1  1 ? 
HETATM 4748 O O2  . FMT P 2 .   ? 26.197  -23.630 -25.365 1.00 44.68 ? 1314 FMT A O2  1 ? 
HETATM 4749 O OXT . RXH Q 4 .   ? 25.993  10.822  -26.387 1.00 32.11 ? 1301 RXH B OXT 1 ? 
HETATM 4750 O O   . RXH Q 4 .   ? 24.766  11.787  -24.837 1.00 28.26 ? 1301 RXH B O   1 ? 
HETATM 4751 C C01 . RXH Q 4 .   ? 25.056  9.764   -26.296 1.00 35.83 ? 1301 RXH B C01 1 ? 
HETATM 4752 C C1  . RXH Q 4 .   ? 31.382  12.171  -20.979 1.00 22.33 ? 1301 RXH B C1  1 ? 
HETATM 4753 C C2  . RXH Q 4 .   ? 30.453  13.055  -20.502 1.00 22.18 ? 1301 RXH B C2  1 ? 
HETATM 4754 O O2  . RXH Q 4 .   ? 32.476  11.865  -20.143 1.00 23.31 ? 1301 RXH B O2  1 ? 
HETATM 4755 C C3  . RXH Q 4 .   ? 29.349  13.405  -21.258 1.00 20.68 ? 1301 RXH B C3  1 ? 
HETATM 4756 C C4  . RXH Q 4 .   ? 29.152  12.912  -22.540 1.00 21.13 ? 1301 RXH B C4  1 ? 
HETATM 4757 C C5  . RXH Q 4 .   ? 30.096  11.985  -23.032 1.00 21.28 ? 1301 RXH B C5  1 ? 
HETATM 4758 C C6  . RXH Q 4 .   ? 31.195  11.630  -22.252 1.00 21.28 ? 1301 RXH B C6  1 ? 
HETATM 4759 C C7  . RXH Q 4 .   ? 28.040  13.248  -23.303 1.00 21.45 ? 1301 RXH B C7  1 ? 
HETATM 4760 C C8  . RXH Q 4 .   ? 27.857  12.696  -24.560 1.00 23.68 ? 1301 RXH B C8  1 ? 
HETATM 4761 C C10 . RXH Q 4 .   ? 25.885  14.281  -25.090 1.00 28.46 ? 1301 RXH B C10 1 ? 
HETATM 4762 C C11 . RXH Q 4 .   ? 28.806  11.800  -25.045 1.00 23.14 ? 1301 RXH B C11 1 ? 
HETATM 4763 C C12 . RXH Q 4 .   ? 33.462  11.015  -20.649 1.00 24.14 ? 1301 RXH B C12 1 ? 
HETATM 4764 C C13 . RXH Q 4 .   ? 29.921  11.436  -24.308 1.00 22.58 ? 1301 RXH B C13 1 ? 
HETATM 4765 C C14 . RXH Q 4 .   ? 26.685  13.036  -25.480 1.00 26.87 ? 1301 RXH B C14 1 ? 
HETATM 4766 C C15 . RXH Q 4 .   ? 25.735  11.849  -25.505 1.00 29.48 ? 1301 RXH B C15 1 ? 
HETATM 4767 C C   . FMT R 2 .   ? 33.930  6.142   -21.797 1.00 46.81 ? 1302 FMT B C   1 ? 
HETATM 4768 O O1  . FMT R 2 .   ? 34.078  5.265   -22.626 1.00 47.68 ? 1302 FMT B O1  1 ? 
HETATM 4769 O O2  . FMT R 2 .   ? 34.471  6.160   -20.618 1.00 38.41 ? 1302 FMT B O2  1 ? 
HETATM 4770 C C   . ACT S 3 .   ? 22.697  13.612  -28.237 1.00 21.66 ? 1303 ACT B C   1 ? 
HETATM 4771 O O   . ACT S 3 .   ? 22.032  12.953  -29.107 1.00 30.27 ? 1303 ACT B O   1 ? 
HETATM 4772 O OXT . ACT S 3 .   ? 22.309  14.652  -27.670 1.00 16.76 ? 1303 ACT B OXT 1 ? 
HETATM 4773 C CH3 . ACT S 3 .   ? 24.078  13.161  -27.907 1.00 19.21 ? 1303 ACT B CH3 1 ? 
HETATM 4774 O O   . HOH T 5 .   ? 0.541   -5.923  -30.649 1.00 30.15 ? 1401 HOH A O   1 ? 
HETATM 4775 O O   . HOH T 5 .   ? 11.240  -8.814  -34.360 1.00 25.19 ? 1402 HOH A O   1 ? 
HETATM 4776 O O   . HOH T 5 .   ? -0.516  -3.568  -31.260 1.00 40.75 ? 1403 HOH A O   1 ? 
HETATM 4777 O O   . HOH T 5 .   ? 24.508  -6.287  -22.600 1.00 36.14 ? 1404 HOH A O   1 ? 
HETATM 4778 O O   . HOH T 5 .   ? 24.757  -10.502 2.573   1.00 34.21 ? 1405 HOH A O   1 ? 
HETATM 4779 O O   . HOH T 5 .   ? 18.272  -1.221  -26.668 1.00 14.27 ? 1406 HOH A O   1 ? 
HETATM 4780 O O   . HOH T 5 .   ? -2.071  -20.275 3.924   1.00 33.35 ? 1407 HOH A O   1 ? 
HETATM 4781 O O   . HOH T 5 .   ? 17.829  7.212   6.265   1.00 36.02 ? 1408 HOH A O   1 ? 
HETATM 4782 O O   . HOH T 5 .   ? -2.998  10.201  -19.562 1.00 44.45 ? 1409 HOH A O   1 ? 
HETATM 4783 O O   . HOH T 5 .   ? 14.238  3.945   9.943   1.00 30.92 ? 1410 HOH A O   1 ? 
HETATM 4784 O O   . HOH T 5 .   ? -7.167  1.934   -1.334  1.00 35.41 ? 1411 HOH A O   1 ? 
HETATM 4785 O O   . HOH T 5 .   ? 21.903  -23.357 -23.796 1.00 32.86 ? 1412 HOH A O   1 ? 
HETATM 4786 O O   . HOH T 5 .   ? -4.674  -11.345 5.263   1.00 35.34 ? 1413 HOH A O   1 ? 
HETATM 4787 O O   . HOH T 5 .   ? -4.988  5.623   -12.352 1.00 41.20 ? 1414 HOH A O   1 ? 
HETATM 4788 O O   . HOH T 5 .   ? -8.360  -13.083 2.593   1.00 84.72 ? 1415 HOH A O   1 ? 
HETATM 4789 O O   . HOH T 5 .   ? 0.358   16.032  -8.449  1.00 54.60 ? 1416 HOH A O   1 ? 
HETATM 4790 O O   . HOH T 5 .   ? -5.847  -3.910  13.801  1.00 41.26 ? 1417 HOH A O   1 ? 
HETATM 4791 O O   . HOH T 5 .   ? 7.393   -29.885 3.906   1.00 37.41 ? 1418 HOH A O   1 ? 
HETATM 4792 O O   . HOH T 5 .   ? -7.227  -1.105  -29.753 1.00 33.65 ? 1419 HOH A O   1 ? 
HETATM 4793 O O   . HOH T 5 .   ? -17.868 -9.180  -18.120 1.00 43.89 ? 1420 HOH A O   1 ? 
HETATM 4794 O O   . HOH T 5 .   ? -5.414  -15.808 5.846   1.00 40.30 ? 1421 HOH A O   1 ? 
HETATM 4795 O O   . HOH T 5 .   ? -0.170  14.353  -1.965  1.00 38.26 ? 1422 HOH A O   1 ? 
HETATM 4796 O O   . HOH T 5 .   ? 16.691  -27.701 -17.813 1.00 37.42 ? 1423 HOH A O   1 ? 
HETATM 4797 O O   . HOH T 5 .   ? 1.014   -9.447  12.171  1.00 33.62 ? 1424 HOH A O   1 ? 
HETATM 4798 O O   . HOH T 5 .   ? 16.572  0.972   10.495  1.00 26.41 ? 1425 HOH A O   1 ? 
HETATM 4799 O O   . HOH T 5 .   ? 11.692  2.933   5.762   1.00 39.46 ? 1426 HOH A O   1 ? 
HETATM 4800 O O   . HOH T 5 .   ? -21.915 -0.864  -20.130 1.00 42.29 ? 1427 HOH A O   1 ? 
HETATM 4801 O O   . HOH T 5 .   ? -6.251  11.439  3.005   1.00 42.90 ? 1428 HOH A O   1 ? 
HETATM 4802 O O   . HOH T 5 .   ? 19.084  -21.398 -2.862  1.00 22.87 ? 1429 HOH A O   1 ? 
HETATM 4803 O O   . HOH T 5 .   ? -5.780  12.949  -1.353  1.00 38.82 ? 1430 HOH A O   1 ? 
HETATM 4804 O O   . HOH T 5 .   ? 2.609   -29.873 -9.804  1.00 41.88 ? 1431 HOH A O   1 ? 
HETATM 4805 O O   . HOH T 5 .   ? 9.139   9.578   -16.490 1.00 30.83 ? 1432 HOH A O   1 ? 
HETATM 4806 O O   . HOH T 5 .   ? 12.927  -13.160 -30.791 1.00 17.15 ? 1433 HOH A O   1 ? 
HETATM 4807 O O   . HOH T 5 .   ? -15.876 -10.958 -10.306 1.00 30.25 ? 1434 HOH A O   1 ? 
HETATM 4808 O O   . HOH T 5 .   ? 14.493  2.192   11.611  1.00 45.64 ? 1435 HOH A O   1 ? 
HETATM 4809 O O   . HOH T 5 .   ? -1.284  -14.794 5.663   1.00 37.01 ? 1436 HOH A O   1 ? 
HETATM 4810 O O   . HOH T 5 .   ? 17.197  -26.140 -11.898 1.00 27.85 ? 1437 HOH A O   1 ? 
HETATM 4811 O O   . HOH T 5 .   ? 25.130  4.857   -8.300  1.00 49.47 ? 1438 HOH A O   1 ? 
HETATM 4812 O O   . HOH T 5 .   ? 8.082   16.518  -2.823  1.00 65.19 ? 1439 HOH A O   1 ? 
HETATM 4813 O O   . HOH T 5 .   ? 17.717  -0.520  8.530   1.00 35.02 ? 1440 HOH A O   1 ? 
HETATM 4814 O O   . HOH T 5 .   ? 10.483  2.346   -27.433 1.00 35.00 ? 1441 HOH A O   1 ? 
HETATM 4815 O O   . HOH T 5 .   ? -13.144 -16.923 -18.070 1.00 40.21 ? 1442 HOH A O   1 ? 
HETATM 4816 O O   . HOH T 5 .   ? 9.909   -2.321  -10.631 1.00 14.27 ? 1443 HOH A O   1 ? 
HETATM 4817 O O   . HOH T 5 .   ? 1.487   9.750   6.335   1.00 33.61 ? 1444 HOH A O   1 ? 
HETATM 4818 O O   . HOH T 5 .   ? 20.452  -17.897 -4.424  1.00 25.95 ? 1445 HOH A O   1 ? 
HETATM 4819 O O   . HOH T 5 .   ? 14.667  -27.938 -19.546 1.00 39.69 ? 1446 HOH A O   1 ? 
HETATM 4820 O O   . HOH T 5 .   ? 16.835  0.652   -26.210 1.00 27.49 ? 1447 HOH A O   1 ? 
HETATM 4821 O O   . HOH T 5 .   ? -3.282  12.956  5.271   1.00 34.99 ? 1448 HOH A O   1 ? 
HETATM 4822 O O   . HOH T 5 .   ? 10.231  -25.251 -16.708 1.00 16.73 ? 1449 HOH A O   1 ? 
HETATM 4823 O O   . HOH T 5 .   ? -19.779 -9.556  -21.844 1.00 37.91 ? 1450 HOH A O   1 ? 
HETATM 4824 O O   . HOH T 5 .   ? 5.913   -4.141  11.733  1.00 33.79 ? 1451 HOH A O   1 ? 
HETATM 4825 O O   . HOH T 5 .   ? -3.979  7.251   7.821   1.00 26.18 ? 1452 HOH A O   1 ? 
HETATM 4826 O O   . HOH T 5 .   ? 25.193  -12.337 -9.933  1.00 38.39 ? 1453 HOH A O   1 ? 
HETATM 4827 O O   . HOH T 5 .   ? -11.165 -6.598  -1.560  1.00 26.09 ? 1454 HOH A O   1 ? 
HETATM 4828 O O   . HOH T 5 .   ? 5.902   9.839   -21.168 1.00 45.28 ? 1455 HOH A O   1 ? 
HETATM 4829 O O   . HOH T 5 .   ? 3.119   -3.608  -26.041 1.00 24.96 ? 1456 HOH A O   1 ? 
HETATM 4830 O O   . HOH T 5 .   ? 12.981  -1.746  -15.444 1.00 14.27 ? 1457 HOH A O   1 ? 
HETATM 4831 O O   . HOH T 5 .   ? 5.879   -11.777 8.896   1.00 31.86 ? 1458 HOH A O   1 ? 
HETATM 4832 O O   . HOH T 5 .   ? -2.356  -10.758 -10.793 1.00 23.33 ? 1459 HOH A O   1 ? 
HETATM 4833 O O   . HOH T 5 .   ? -0.004  -16.324 3.462   1.00 21.46 ? 1460 HOH A O   1 ? 
HETATM 4834 O O   . HOH T 5 .   ? 6.718   -20.491 7.286   1.00 24.66 ? 1461 HOH A O   1 ? 
HETATM 4835 O O   . HOH T 5 .   ? 20.770  7.596   -3.193  1.00 34.22 ? 1462 HOH A O   1 ? 
HETATM 4836 O O   . HOH T 5 .   ? -10.567 -3.392  -32.226 1.00 35.61 ? 1463 HOH A O   1 ? 
HETATM 4837 O O   . HOH T 5 .   ? -15.882 -9.548  -7.386  1.00 41.21 ? 1464 HOH A O   1 ? 
HETATM 4838 O O   . HOH T 5 .   ? -24.035 -0.811  -17.099 1.00 33.72 ? 1465 HOH A O   1 ? 
HETATM 4839 O O   . HOH T 5 .   ? 10.502  -12.375 7.604   1.00 30.75 ? 1466 HOH A O   1 ? 
HETATM 4840 O O   . HOH T 5 .   ? 10.808  -15.729 -13.095 1.00 12.96 ? 1467 HOH A O   1 ? 
HETATM 4841 O O   . HOH T 5 .   ? 24.292  -13.465 -17.948 1.00 27.23 ? 1468 HOH A O   1 ? 
HETATM 4842 O O   . HOH T 5 .   ? 9.869   -19.486 8.356   1.00 31.24 ? 1469 HOH A O   1 ? 
HETATM 4843 O O   . HOH T 5 .   ? 14.426  -13.679 -12.258 1.00 15.01 ? 1470 HOH A O   1 ? 
HETATM 4844 O O   . HOH T 5 .   ? 0.745   -16.952 -12.385 1.00 12.97 ? 1471 HOH A O   1 ? 
HETATM 4845 O O   . HOH T 5 .   ? 2.859   -26.170 -22.986 1.00 30.19 ? 1472 HOH A O   1 ? 
HETATM 4846 O O   . HOH T 5 .   ? 11.180  -0.585  -33.592 1.00 37.02 ? 1473 HOH A O   1 ? 
HETATM 4847 O O   . HOH T 5 .   ? -4.427  -27.042 -15.050 1.00 37.08 ? 1474 HOH A O   1 ? 
HETATM 4848 O O   . HOH T 5 .   ? 8.483   -28.662 -13.739 1.00 32.88 ? 1475 HOH A O   1 ? 
HETATM 4849 O O   . HOH T 5 .   ? 0.776   3.571   10.381  1.00 29.85 ? 1476 HOH A O   1 ? 
HETATM 4850 O O   . HOH T 5 .   ? -5.185  -6.338  7.677   1.00 32.63 ? 1477 HOH A O   1 ? 
HETATM 4851 O O   . HOH T 5 .   ? -7.042  -2.372  1.841   1.00 27.20 ? 1478 HOH A O   1 ? 
HETATM 4852 O O   . HOH T 5 .   ? -12.433 -14.023 -18.669 1.00 25.67 ? 1479 HOH A O   1 ? 
HETATM 4853 O O   . HOH T 5 .   ? 18.117  -18.508 -24.446 1.00 26.37 ? 1480 HOH A O   1 ? 
HETATM 4854 O O   . HOH T 5 .   ? 22.256  -20.407 -15.548 1.00 42.82 ? 1481 HOH A O   1 ? 
HETATM 4855 O O   . HOH T 5 .   ? -0.590  -0.781  -27.036 1.00 37.99 ? 1482 HOH A O   1 ? 
HETATM 4856 O O   . HOH T 5 .   ? 12.905  2.178   -24.591 1.00 36.11 ? 1483 HOH A O   1 ? 
HETATM 4857 O O   . HOH T 5 .   ? 1.156   -2.687  -28.105 1.00 28.87 ? 1484 HOH A O   1 ? 
HETATM 4858 O O   . HOH T 5 .   ? 26.166  -7.284  -13.727 1.00 40.51 ? 1485 HOH A O   1 ? 
HETATM 4859 O O   . HOH T 5 .   ? -4.363  -14.189 -26.855 1.00 32.24 ? 1486 HOH A O   1 ? 
HETATM 4860 O O   . HOH T 5 .   ? 1.305   -32.140 -8.114  1.00 39.14 ? 1487 HOH A O   1 ? 
HETATM 4861 O O   . HOH T 5 .   ? 17.893  -8.886  -16.394 1.00 13.31 ? 1488 HOH A O   1 ? 
HETATM 4862 O O   . HOH T 5 .   ? 0.743   -27.091 -21.701 1.00 24.41 ? 1489 HOH A O   1 ? 
HETATM 4863 O O   . HOH T 5 .   ? 23.285  -7.129  -6.163  1.00 30.85 ? 1490 HOH A O   1 ? 
HETATM 4864 O O   . HOH T 5 .   ? -1.256  6.861   -24.597 1.00 34.34 ? 1491 HOH A O   1 ? 
HETATM 4865 O O   . HOH T 5 .   ? -8.282  -1.326  -31.965 1.00 52.04 ? 1492 HOH A O   1 ? 
HETATM 4866 O O   . HOH T 5 .   ? 5.102   14.079  -7.786  1.00 36.30 ? 1493 HOH A O   1 ? 
HETATM 4867 O O   . HOH T 5 .   ? 10.890  -15.736 6.751   1.00 40.66 ? 1494 HOH A O   1 ? 
HETATM 4868 O O   . HOH T 5 .   ? 2.838   0.149   14.110  1.00 37.57 ? 1495 HOH A O   1 ? 
HETATM 4869 O O   . HOH T 5 .   ? -11.121 -13.802 -21.187 1.00 32.30 ? 1496 HOH A O   1 ? 
HETATM 4870 O O   . HOH T 5 .   ? 4.646   -11.099 -33.284 1.00 52.24 ? 1497 HOH A O   1 ? 
HETATM 4871 O O   . HOH T 5 .   ? -0.513  -20.452 -25.145 1.00 21.11 ? 1498 HOH A O   1 ? 
HETATM 4872 O O   . HOH T 5 .   ? -6.223  -27.079 -17.088 1.00 38.84 ? 1499 HOH A O   1 ? 
HETATM 4873 O O   . HOH T 5 .   ? 11.546  -22.803 -16.349 1.00 16.31 ? 1500 HOH A O   1 ? 
HETATM 4874 O O   . HOH T 5 .   ? 9.007   -19.986 5.953   1.00 18.45 ? 1501 HOH A O   1 ? 
HETATM 4875 O O   . HOH T 5 .   ? 4.101   0.098   -30.349 1.00 28.06 ? 1502 HOH A O   1 ? 
HETATM 4876 O O   . HOH T 5 .   ? 23.565  -9.649  -17.413 1.00 24.74 ? 1503 HOH A O   1 ? 
HETATM 4877 O O   . HOH T 5 .   ? -7.245  -24.085 -6.696  1.00 37.19 ? 1504 HOH A O   1 ? 
HETATM 4878 O O   . HOH T 5 .   ? 6.800   -11.045 -26.771 1.00 41.18 ? 1505 HOH A O   1 ? 
HETATM 4879 O O   . HOH T 5 .   ? 11.559  -30.218 2.098   1.00 38.66 ? 1506 HOH A O   1 ? 
HETATM 4880 O O   . HOH T 5 .   ? 12.101  3.361   8.733   1.00 27.19 ? 1507 HOH A O   1 ? 
HETATM 4881 O O   . HOH T 5 .   ? 15.360  -8.131  -16.809 1.00 27.96 ? 1508 HOH A O   1 ? 
HETATM 4882 O O   . HOH T 5 .   ? -15.128 -19.374 -15.283 1.00 41.87 ? 1509 HOH A O   1 ? 
HETATM 4883 O O   . HOH T 5 .   ? -3.761  -14.701 3.927   1.00 26.28 ? 1510 HOH A O   1 ? 
HETATM 4884 O O   . HOH T 5 .   ? -10.958 -18.357 -27.825 1.00 49.94 ? 1511 HOH A O   1 ? 
HETATM 4885 O O   . HOH T 5 .   ? 24.567  -21.302 -22.324 1.00 41.07 ? 1512 HOH A O   1 ? 
HETATM 4886 O O   . HOH T 5 .   ? 13.408  -25.820 -22.954 1.00 30.39 ? 1513 HOH A O   1 ? 
HETATM 4887 O O   . HOH T 5 .   ? 6.261   -1.889  13.051  1.00 40.05 ? 1514 HOH A O   1 ? 
HETATM 4888 O O   . HOH T 5 .   ? -5.795  1.840   -3.858  1.00 23.34 ? 1515 HOH A O   1 ? 
HETATM 4889 O O   . HOH T 5 .   ? -9.802  -23.107 -13.999 1.00 38.70 ? 1516 HOH A O   1 ? 
HETATM 4890 O O   . HOH T 5 .   ? -6.135  -11.154 -30.748 1.00 45.91 ? 1517 HOH A O   1 ? 
HETATM 4891 O O   . HOH T 5 .   ? -0.363  -9.718  -26.072 1.00 23.45 ? 1518 HOH A O   1 ? 
HETATM 4892 O O   . HOH T 5 .   ? 1.238   -21.966 -16.611 1.00 16.39 ? 1519 HOH A O   1 ? 
HETATM 4893 O O   . HOH T 5 .   ? 10.003  -22.521 5.384   1.00 15.81 ? 1520 HOH A O   1 ? 
HETATM 4894 O O   . HOH T 5 .   ? 13.787  -0.577  14.211  1.00 46.97 ? 1521 HOH A O   1 ? 
HETATM 4895 O O   . HOH T 5 .   ? 6.149   -7.436  10.835  1.00 21.78 ? 1522 HOH A O   1 ? 
HETATM 4896 O O   . HOH T 5 .   ? 9.635   -27.162 -2.187  1.00 21.93 ? 1523 HOH A O   1 ? 
HETATM 4897 O O   . HOH T 5 .   ? 13.761  -14.297 -28.476 1.00 15.99 ? 1524 HOH A O   1 ? 
HETATM 4898 O O   . HOH T 5 .   ? -5.037  -25.197 -12.696 1.00 39.90 ? 1525 HOH A O   1 ? 
HETATM 4899 O O   . HOH T 5 .   ? 15.090  3.427   3.527   1.00 27.45 ? 1526 HOH A O   1 ? 
HETATM 4900 O O   . HOH T 5 .   ? -2.416  1.127   -14.024 1.00 18.60 ? 1527 HOH A O   1 ? 
HETATM 4901 O O   . HOH T 5 .   ? -5.084  -13.349 -19.167 1.00 17.01 ? 1528 HOH A O   1 ? 
HETATM 4902 O O   . HOH T 5 .   ? 9.874   6.004   -22.123 1.00 48.21 ? 1529 HOH A O   1 ? 
HETATM 4903 O O   . HOH T 5 .   ? 17.488  -18.577 -26.671 1.00 21.30 ? 1530 HOH A O   1 ? 
HETATM 4904 O O   . HOH T 5 .   ? -4.538  5.548   1.707   1.00 30.46 ? 1531 HOH A O   1 ? 
HETATM 4905 O O   . HOH T 5 .   ? 0.346   13.369  -9.060  1.00 33.88 ? 1532 HOH A O   1 ? 
HETATM 4906 O O   . HOH T 5 .   ? 22.491  -14.491 -3.118  1.00 23.38 ? 1533 HOH A O   1 ? 
HETATM 4907 O O   . HOH T 5 .   ? 13.764  -10.816 9.036   1.00 26.65 ? 1534 HOH A O   1 ? 
HETATM 4908 O O   . HOH T 5 .   ? 10.515  -0.724  -21.068 1.00 21.82 ? 1535 HOH A O   1 ? 
HETATM 4909 O O   . HOH T 5 .   ? 11.145  0.888   8.770   1.00 24.79 ? 1536 HOH A O   1 ? 
HETATM 4910 O O   . HOH T 5 .   ? -15.002 -10.153 -26.029 1.00 33.05 ? 1537 HOH A O   1 ? 
HETATM 4911 O O   . HOH T 5 .   ? 4.833   -20.716 -17.928 1.00 15.39 ? 1538 HOH A O   1 ? 
HETATM 4912 O O   . HOH T 5 .   ? 5.093   1.551   10.897  1.00 36.70 ? 1539 HOH A O   1 ? 
HETATM 4913 O O   . HOH T 5 .   ? 7.808   10.660  -3.323  1.00 28.85 ? 1540 HOH A O   1 ? 
HETATM 4914 O O   . HOH T 5 .   ? -16.869 -17.033 -17.519 1.00 49.53 ? 1541 HOH A O   1 ? 
HETATM 4915 O O   . HOH T 5 .   ? 27.901  -9.788  -11.317 1.00 40.76 ? 1542 HOH A O   1 ? 
HETATM 4916 O O   . HOH T 5 .   ? -12.945 -12.458 -26.166 1.00 36.19 ? 1543 HOH A O   1 ? 
HETATM 4917 O O   . HOH T 5 .   ? -1.420  -15.541 -18.161 1.00 14.05 ? 1544 HOH A O   1 ? 
HETATM 4918 O O   . HOH T 5 .   ? 24.463  -18.869 -21.947 1.00 40.59 ? 1545 HOH A O   1 ? 
HETATM 4919 O O   . HOH T 5 .   ? 21.419  -17.480 -11.701 1.00 19.14 ? 1546 HOH A O   1 ? 
HETATM 4920 O O   . HOH T 5 .   ? 14.267  7.122   -11.515 1.00 31.67 ? 1547 HOH A O   1 ? 
HETATM 4921 O O   . HOH T 5 .   ? -12.883 0.109   -10.644 1.00 34.43 ? 1548 HOH A O   1 ? 
HETATM 4922 O O   . HOH T 5 .   ? -16.569 -14.108 -12.407 1.00 43.44 ? 1549 HOH A O   1 ? 
HETATM 4923 O O   . HOH T 5 .   ? 12.471  6.134   11.040  1.00 36.25 ? 1550 HOH A O   1 ? 
HETATM 4924 O O   . HOH T 5 .   ? 17.960  -20.880 -22.969 1.00 24.96 ? 1551 HOH A O   1 ? 
HETATM 4925 O O   . HOH T 5 .   ? 22.963  -3.699  -9.095  1.00 39.87 ? 1552 HOH A O   1 ? 
HETATM 4926 O O   . HOH T 5 .   ? 2.897   -28.859 -1.447  1.00 25.84 ? 1553 HOH A O   1 ? 
HETATM 4927 O O   . HOH T 5 .   ? -3.540  -4.338  16.395  1.00 40.47 ? 1554 HOH A O   1 ? 
HETATM 4928 O O   . HOH T 5 .   ? 4.598   5.157   -26.087 1.00 27.26 ? 1555 HOH A O   1 ? 
HETATM 4929 O O   . HOH T 5 .   ? 3.225   -22.841 -18.326 1.00 17.96 ? 1556 HOH A O   1 ? 
HETATM 4930 O O   . HOH T 5 .   ? 12.756  -19.539 -24.888 1.00 20.86 ? 1557 HOH A O   1 ? 
HETATM 4931 O O   . HOH T 5 .   ? -6.808  -16.154 -26.883 1.00 31.63 ? 1558 HOH A O   1 ? 
HETATM 4932 O O   . HOH T 5 .   ? 8.630   -17.984 -29.442 1.00 24.63 ? 1559 HOH A O   1 ? 
HETATM 4933 O O   . HOH T 5 .   ? 19.975  -11.593 -24.400 1.00 25.74 ? 1560 HOH A O   1 ? 
HETATM 4934 O O   . HOH T 5 .   ? 3.499   -29.701 -20.736 1.00 51.81 ? 1561 HOH A O   1 ? 
HETATM 4935 O O   . HOH T 5 .   ? 0.220   0.807   6.856   1.00 21.99 ? 1562 HOH A O   1 ? 
HETATM 4936 O O   . HOH T 5 .   ? 16.221  6.017   1.701   1.00 36.09 ? 1563 HOH A O   1 ? 
HETATM 4937 O O   . HOH T 5 .   ? -14.306 -9.297  -4.119  1.00 30.88 ? 1564 HOH A O   1 ? 
HETATM 4938 O O   . HOH T 5 .   ? 3.497   -0.769  -32.953 1.00 36.62 ? 1565 HOH A O   1 ? 
HETATM 4939 O O   . HOH T 5 .   ? 3.455   -12.062 10.026  1.00 40.85 ? 1566 HOH A O   1 ? 
HETATM 4940 O O   . HOH T 5 .   ? 7.574   -23.447 8.425   1.00 49.42 ? 1567 HOH A O   1 ? 
HETATM 4941 O O   . HOH T 5 .   ? 22.193  -26.642 -16.194 1.00 47.46 ? 1568 HOH A O   1 ? 
HETATM 4942 O O   . HOH T 5 .   ? 12.595  -21.164 -22.611 1.00 20.51 ? 1569 HOH A O   1 ? 
HETATM 4943 O O   . HOH T 5 .   ? 2.537   10.646  2.858   1.00 30.94 ? 1570 HOH A O   1 ? 
HETATM 4944 O O   . HOH T 5 .   ? -6.219  1.189   -13.997 1.00 21.77 ? 1571 HOH A O   1 ? 
HETATM 4945 O O   . HOH T 5 .   ? 22.848  -9.087  -23.936 1.00 17.15 ? 1572 HOH A O   1 ? 
HETATM 4946 O O   . HOH T 5 .   ? 24.702  -8.367  -22.184 1.00 24.14 ? 1573 HOH A O   1 ? 
HETATM 4947 O O   . HOH T 5 .   ? 5.732   -28.439 -14.262 1.00 22.88 ? 1574 HOH A O   1 ? 
HETATM 4948 O O   . HOH T 5 .   ? 22.225  -3.464  3.677   1.00 31.96 ? 1575 HOH A O   1 ? 
HETATM 4949 O O   . HOH T 5 .   ? 5.354   -27.362 -7.848  1.00 21.68 ? 1576 HOH A O   1 ? 
HETATM 4950 O O   . HOH T 5 .   ? 13.924  -27.573 1.779   1.00 40.71 ? 1577 HOH A O   1 ? 
HETATM 4951 O O   . HOH T 5 .   ? 14.008  -30.065 -13.256 1.00 36.84 ? 1578 HOH A O   1 ? 
HETATM 4952 O O   . HOH T 5 .   ? -1.498  5.843   7.604   1.00 22.09 ? 1579 HOH A O   1 ? 
HETATM 4953 O O   . HOH T 5 .   ? 0.292   0.796   -13.562 1.00 16.85 ? 1580 HOH A O   1 ? 
HETATM 4954 O O   . HOH T 5 .   ? 13.459  -6.450  -31.411 1.00 21.74 ? 1581 HOH A O   1 ? 
HETATM 4955 O O   . HOH T 5 .   ? 11.701  4.122   -20.779 1.00 26.97 ? 1582 HOH A O   1 ? 
HETATM 4956 O O   . HOH T 5 .   ? 9.817   -6.990  -17.211 1.00 10.52 ? 1583 HOH A O   1 ? 
HETATM 4957 O O   . HOH T 5 .   ? 22.855  -22.411 -17.644 1.00 29.16 ? 1584 HOH A O   1 ? 
HETATM 4958 O O   . HOH T 5 .   ? 19.112  -0.790  -12.979 1.00 25.71 ? 1585 HOH A O   1 ? 
HETATM 4959 O O   . HOH T 5 .   ? 22.234  -1.546  -11.942 1.00 35.75 ? 1586 HOH A O   1 ? 
HETATM 4960 O O   . HOH T 5 .   ? 9.816   -27.780 -9.420  1.00 26.97 ? 1587 HOH A O   1 ? 
HETATM 4961 O O   . HOH T 5 .   ? 24.904  0.935   -11.427 1.00 48.33 ? 1588 HOH A O   1 ? 
HETATM 4962 O O   . HOH T 5 .   ? 2.295   6.285   -17.743 1.00 29.49 ? 1589 HOH A O   1 ? 
HETATM 4963 O O   . HOH T 5 .   ? 6.280   -18.205 5.677   1.00 17.37 ? 1590 HOH A O   1 ? 
HETATM 4964 O O   . HOH T 5 .   ? 0.773   -16.286 -29.844 1.00 36.04 ? 1591 HOH A O   1 ? 
HETATM 4965 O O   . HOH T 5 .   ? -11.084 -6.662  -30.109 1.00 44.15 ? 1592 HOH A O   1 ? 
HETATM 4966 O O   . HOH T 5 .   ? 5.647   -12.245 -29.614 1.00 31.35 ? 1593 HOH A O   1 ? 
HETATM 4967 O O   . HOH T 5 .   ? 1.735   -19.353 -28.683 1.00 24.02 ? 1594 HOH A O   1 ? 
HETATM 4968 O O   . HOH T 5 .   ? 22.138  -24.154 -21.479 1.00 40.17 ? 1595 HOH A O   1 ? 
HETATM 4969 O O   . HOH T 5 .   ? 21.178  4.475   -10.563 1.00 34.80 ? 1596 HOH A O   1 ? 
HETATM 4970 O O   . HOH T 5 .   ? -5.988  5.797   -7.338  1.00 28.18 ? 1597 HOH A O   1 ? 
HETATM 4971 O O   . HOH T 5 .   ? 16.529  7.282   4.425   1.00 50.93 ? 1598 HOH A O   1 ? 
HETATM 4972 O O   . HOH T 5 .   ? -20.473 -4.364  -14.082 1.00 47.14 ? 1599 HOH A O   1 ? 
HETATM 4973 O O   . HOH T 5 .   ? 14.483  -17.226 6.585   1.00 32.46 ? 1600 HOH A O   1 ? 
HETATM 4974 O O   . HOH T 5 .   ? -9.771  -7.440  -32.398 1.00 50.36 ? 1601 HOH A O   1 ? 
HETATM 4975 O O   . HOH T 5 .   ? 1.271   3.880   -14.684 1.00 14.77 ? 1602 HOH A O   1 ? 
HETATM 4976 O O   . HOH T 5 .   ? -6.800  7.901   -0.690  1.00 39.99 ? 1603 HOH A O   1 ? 
HETATM 4977 O O   . HOH T 5 .   ? -3.725  8.141   0.766   1.00 25.63 ? 1604 HOH A O   1 ? 
HETATM 4978 O O   . HOH T 5 .   ? -1.092  2.827   -15.754 1.00 20.64 ? 1605 HOH A O   1 ? 
HETATM 4979 O O   . HOH T 5 .   ? 7.472   -0.589  -21.518 1.00 14.00 ? 1606 HOH A O   1 ? 
HETATM 4980 O O   . HOH T 5 .   ? 11.870  -25.495 -2.479  1.00 20.03 ? 1607 HOH A O   1 ? 
HETATM 4981 O O   . HOH T 5 .   ? -7.420  -23.349 -24.767 1.00 29.35 ? 1608 HOH A O   1 ? 
HETATM 4982 O O   . HOH T 5 .   ? 6.746   -19.304 -35.019 1.00 61.36 ? 1609 HOH A O   1 ? 
HETATM 4983 O O   . HOH T 5 .   ? -6.511  13.648  -9.317  1.00 51.24 ? 1610 HOH A O   1 ? 
HETATM 4984 O O   . HOH T 5 .   ? 1.814   15.723  -6.323  1.00 46.06 ? 1611 HOH A O   1 ? 
HETATM 4985 O O   . HOH T 5 .   ? 18.900  -14.759 5.400   1.00 20.29 ? 1612 HOH A O   1 ? 
HETATM 4986 O O   . HOH T 5 .   ? -9.611  -26.110 -22.364 1.00 48.15 ? 1613 HOH A O   1 ? 
HETATM 4987 O O   . HOH T 5 .   ? 22.319  2.188   -12.960 1.00 39.74 ? 1614 HOH A O   1 ? 
HETATM 4988 O O   . HOH T 5 .   ? 21.934  6.547   -0.492  1.00 36.73 ? 1615 HOH A O   1 ? 
HETATM 4989 O O   . HOH T 5 .   ? -13.024 -12.534 -9.880  1.00 32.07 ? 1616 HOH A O   1 ? 
HETATM 4990 O O   . HOH T 5 .   ? -0.164  -30.147 -4.673  1.00 44.48 ? 1617 HOH A O   1 ? 
HETATM 4991 O O   . HOH T 5 .   ? 20.941  1.006   8.547   1.00 49.93 ? 1618 HOH A O   1 ? 
HETATM 4992 O O   . HOH T 5 .   ? 16.023  -4.246  -27.502 1.00 36.23 ? 1619 HOH A O   1 ? 
HETATM 4993 O O   . HOH T 5 .   ? 24.655  -9.569  -14.648 1.00 33.49 ? 1620 HOH A O   1 ? 
HETATM 4994 O O   . HOH T 5 .   ? 10.939  -29.039 -20.834 1.00 44.91 ? 1621 HOH A O   1 ? 
HETATM 4995 O O   . HOH T 5 .   ? 4.664   -29.537 -16.506 1.00 45.43 ? 1622 HOH A O   1 ? 
HETATM 4996 O O   . HOH T 5 .   ? 7.924   -28.021 -7.309  1.00 36.56 ? 1623 HOH A O   1 ? 
HETATM 4997 O O   . HOH T 5 .   ? 15.236  -13.527 7.652   1.00 21.37 ? 1624 HOH A O   1 ? 
HETATM 4998 O O   . HOH T 5 .   ? -6.477  13.088  5.633   1.00 57.62 ? 1625 HOH A O   1 ? 
HETATM 4999 O O   . HOH T 5 .   ? 0.421   -27.868 -8.271  1.00 37.07 ? 1626 HOH A O   1 ? 
HETATM 5000 O O   . HOH T 5 .   ? -10.289 2.208   -8.620  1.00 38.28 ? 1627 HOH A O   1 ? 
HETATM 5001 O O   . HOH T 5 .   ? 13.709  -3.028  -30.879 1.00 20.21 ? 1628 HOH A O   1 ? 
HETATM 5002 O O   . HOH T 5 .   ? 19.119  9.703   -5.010  1.00 35.49 ? 1629 HOH A O   1 ? 
HETATM 5003 O O   . HOH T 5 .   ? -12.310 -14.177 -23.499 1.00 44.49 ? 1630 HOH A O   1 ? 
HETATM 5004 O O   . HOH T 5 .   ? 17.781  8.118   -10.328 1.00 37.16 ? 1631 HOH A O   1 ? 
HETATM 5005 O O   . HOH T 5 .   ? 17.705  -22.136 -5.032  1.00 18.68 ? 1632 HOH A O   1 ? 
HETATM 5006 O O   . HOH T 5 .   ? 20.225  -19.521 -10.174 1.00 18.81 ? 1633 HOH A O   1 ? 
HETATM 5007 O O   . HOH T 5 .   ? -17.663 -7.512  -27.250 1.00 18.97 ? 1634 HOH A O   1 ? 
HETATM 5008 O O   . HOH T 5 .   ? -6.794  10.828  -5.114  1.00 44.33 ? 1635 HOH A O   1 ? 
HETATM 5009 O O   . HOH T 5 .   ? 19.700  -12.183 8.681   1.00 32.03 ? 1636 HOH A O   1 ? 
HETATM 5010 O O   . HOH T 5 .   ? 10.730  -9.412  8.940   1.00 32.69 ? 1637 HOH A O   1 ? 
HETATM 5011 O O   . HOH T 5 .   ? 0.367   -11.951 10.696  1.00 56.50 ? 1638 HOH A O   1 ? 
HETATM 5012 O O   . HOH T 5 .   ? -15.372 -2.763  -6.362  1.00 40.86 ? 1639 HOH A O   1 ? 
HETATM 5013 O O   . HOH T 5 .   ? -10.014 -12.719 2.502   1.00 32.41 ? 1640 HOH A O   1 ? 
HETATM 5014 O O   . HOH T 5 .   ? 0.734   -28.136 -14.860 1.00 24.80 ? 1641 HOH A O   1 ? 
HETATM 5015 O O   . HOH T 5 .   ? 13.582  8.455   2.059   1.00 43.55 ? 1642 HOH A O   1 ? 
HETATM 5016 O O   . HOH T 5 .   ? 9.324   0.336   -12.698 1.00 44.08 ? 1643 HOH A O   1 ? 
HETATM 5017 O O   . HOH T 5 .   ? 13.785  -18.385 8.937   1.00 35.93 ? 1644 HOH A O   1 ? 
HETATM 5018 O O   . HOH T 5 .   ? -8.306  -3.626  5.931   1.00 48.81 ? 1645 HOH A O   1 ? 
HETATM 5019 O O   . HOH T 5 .   ? -1.626  -18.466 4.938   1.00 45.93 ? 1646 HOH A O   1 ? 
HETATM 5020 O O   . HOH T 5 .   ? 23.466  3.578   -11.472 1.00 58.43 ? 1647 HOH A O   1 ? 
HETATM 5021 O O   . HOH T 5 .   ? -15.328 -12.989 -10.582 1.00 45.56 ? 1648 HOH A O   1 ? 
HETATM 5022 O O   . HOH T 5 .   ? -0.088  -21.607 4.287   1.00 24.42 ? 1649 HOH A O   1 ? 
HETATM 5023 O O   . HOH T 5 .   ? 14.083  6.047   3.141   1.00 47.78 ? 1650 HOH A O   1 ? 
HETATM 5024 O O   . HOH T 5 .   ? -19.143 -19.205 -10.937 1.00 47.10 ? 1651 HOH A O   1 ? 
HETATM 5025 O O   . HOH T 5 .   ? 1.243   -0.582  -31.954 1.00 44.87 ? 1652 HOH A O   1 ? 
HETATM 5026 O O   . HOH T 5 .   ? 5.691   -28.164 4.889   1.00 47.13 ? 1653 HOH A O   1 ? 
HETATM 5027 O O   . HOH T 5 .   ? 22.703  -6.182  3.600   1.00 43.31 ? 1654 HOH A O   1 ? 
HETATM 5028 O O   . HOH T 5 .   ? 26.550  -10.830 -1.086  1.00 31.58 ? 1655 HOH A O   1 ? 
HETATM 5029 O O   . HOH T 5 .   ? 7.419   5.114   -25.140 1.00 40.63 ? 1656 HOH A O   1 ? 
HETATM 5030 O O   . HOH T 5 .   ? 3.329   12.642  1.402   1.00 54.12 ? 1657 HOH A O   1 ? 
HETATM 5031 O O   . HOH T 5 .   ? -18.316 -11.016 -23.654 1.00 33.12 ? 1658 HOH A O   1 ? 
HETATM 5032 O O   . HOH T 5 .   ? 0.692   6.696   -14.640 1.00 28.41 ? 1659 HOH A O   1 ? 
HETATM 5033 O O   . HOH T 5 .   ? 24.469  -21.016 -24.718 1.00 38.51 ? 1660 HOH A O   1 ? 
HETATM 5034 O O   . HOH T 5 .   ? 24.242  -23.623 -22.831 1.00 53.89 ? 1661 HOH A O   1 ? 
HETATM 5035 O O   . HOH T 5 .   ? 8.034   -28.284 5.837   1.00 35.04 ? 1662 HOH A O   1 ? 
HETATM 5036 O O   . HOH T 5 .   ? 27.913  -8.949  2.561   1.00 47.84 ? 1663 HOH A O   1 ? 
HETATM 5037 O O   . HOH T 5 .   ? -21.222 -13.319 -14.308 1.00 42.05 ? 1664 HOH A O   1 ? 
HETATM 5038 O O   . HOH T 5 .   ? 21.548  -11.172 -2.222  1.00 33.87 ? 1665 HOH A O   1 ? 
HETATM 5039 O O   . HOH T 5 .   ? 24.225  -4.720  -1.777  1.00 43.83 ? 1666 HOH A O   1 ? 
HETATM 5040 O O   . HOH T 5 .   ? -5.904  13.078  -6.141  1.00 41.86 ? 1667 HOH A O   1 ? 
HETATM 5041 O O   . HOH T 5 .   ? 10.324  -28.990 -0.296  1.00 29.91 ? 1668 HOH A O   1 ? 
HETATM 5042 O O   . HOH T 5 .   ? 5.450   -6.737  13.646  1.00 40.51 ? 1669 HOH A O   1 ? 
HETATM 5043 O O   . HOH T 5 .   ? 27.855  -7.583  -20.255 1.00 39.84 ? 1670 HOH A O   1 ? 
HETATM 5044 O O   . HOH T 5 .   ? 14.675  12.391  -12.839 1.00 41.73 ? 1671 HOH A O   1 ? 
HETATM 5045 O O   . HOH T 5 .   ? 24.411  -3.845  -22.427 1.00 40.43 ? 1672 HOH A O   1 ? 
HETATM 5046 O O   . HOH T 5 .   ? -18.025 -2.675  -14.427 1.00 37.45 ? 1673 HOH A O   1 ? 
HETATM 5047 O O   . HOH T 5 .   ? 11.544  -18.456 -28.541 1.00 30.05 ? 1674 HOH A O   1 ? 
HETATM 5048 O O   . HOH T 5 .   ? -15.194 -11.098 -22.886 1.00 48.29 ? 1675 HOH A O   1 ? 
HETATM 5049 O O   . HOH T 5 .   ? -11.514 -19.124 -17.132 1.00 39.28 ? 1676 HOH A O   1 ? 
HETATM 5050 O O   . HOH T 5 .   ? 25.946  2.721   -6.586  1.00 46.57 ? 1677 HOH A O   1 ? 
HETATM 5051 O O   . HOH T 5 .   ? 22.984  -7.372  -3.369  1.00 47.99 ? 1678 HOH A O   1 ? 
HETATM 5052 O O   . HOH T 5 .   ? -4.329  -19.414 -28.664 1.00 48.67 ? 1679 HOH A O   1 ? 
HETATM 5053 O O   . HOH T 5 .   ? 8.148   -12.798 8.377   1.00 46.70 ? 1680 HOH A O   1 ? 
HETATM 5054 O O   . HOH T 5 .   ? -12.481 -8.855  -29.687 1.00 37.13 ? 1681 HOH A O   1 ? 
HETATM 5055 O O   . HOH T 5 .   ? 14.957  -19.324 -28.271 1.00 30.68 ? 1682 HOH A O   1 ? 
HETATM 5056 O O   . HOH T 5 .   ? 16.381  5.267   9.718   1.00 48.82 ? 1683 HOH A O   1 ? 
HETATM 5057 O O   . HOH T 5 .   ? 24.321  -5.391  -7.677  1.00 40.03 ? 1684 HOH A O   1 ? 
HETATM 5058 O O   . HOH T 5 .   ? 9.040   -10.799 -33.749 1.00 39.89 ? 1685 HOH A O   1 ? 
HETATM 5059 O O   . HOH T 5 .   ? 26.319  -9.350  -8.176  1.00 50.55 ? 1686 HOH A O   1 ? 
HETATM 5060 O O   . HOH T 5 .   ? -10.000 -25.103 -19.163 1.00 49.96 ? 1687 HOH A O   1 ? 
HETATM 5061 O O   . HOH T 5 .   ? 8.379   -26.224 8.071   1.00 34.91 ? 1688 HOH A O   1 ? 
HETATM 5062 O O   . HOH T 5 .   ? -1.758  -23.946 4.939   1.00 32.41 ? 1689 HOH A O   1 ? 
HETATM 5063 O O   . HOH T 5 .   ? -4.988  -16.033 -28.691 1.00 46.58 ? 1690 HOH A O   1 ? 
HETATM 5064 O O   . HOH T 5 .   ? 0.109   -29.512 -21.676 1.00 41.72 ? 1691 HOH A O   1 ? 
HETATM 5065 O O   . HOH T 5 .   ? 19.351  -23.017 -24.395 1.00 38.48 ? 1692 HOH A O   1 ? 
HETATM 5066 O O   . HOH T 5 .   ? 20.124  7.361   5.274   1.00 47.81 ? 1693 HOH A O   1 ? 
HETATM 5067 O O   . HOH T 5 .   ? -3.850  16.848  -4.801  1.00 45.37 ? 1694 HOH A O   1 ? 
HETATM 5068 O O   . HOH T 5 .   ? 11.902  -33.303 -14.188 1.00 62.82 ? 1695 HOH A O   1 ? 
HETATM 5069 O O   . HOH T 5 .   ? 18.012  2.798   10.901  1.00 43.22 ? 1696 HOH A O   1 ? 
HETATM 5070 O O   . HOH T 5 .   ? 0.378   -21.092 -27.653 1.00 65.99 ? 1697 HOH A O   1 ? 
HETATM 5071 O O   . HOH T 5 .   ? 20.020  -24.629 -22.132 1.00 39.96 ? 1698 HOH A O   1 ? 
HETATM 5072 O O   . HOH T 5 .   ? 2.767   2.261   -29.569 1.00 48.01 ? 1699 HOH A O   1 ? 
HETATM 5073 O O   . HOH T 5 .   ? -17.178 -13.284 -17.351 1.00 50.95 ? 1700 HOH A O   1 ? 
HETATM 5074 O O   . HOH T 5 .   ? 12.645  -8.430  11.103  1.00 51.07 ? 1701 HOH A O   1 ? 
HETATM 5075 O O   . HOH T 5 .   ? -2.309  -20.309 7.882   1.00 39.20 ? 1702 HOH A O   1 ? 
HETATM 5076 O O   . HOH T 5 .   ? 5.842   2.092   -34.858 1.00 46.95 ? 1703 HOH A O   1 ? 
HETATM 5077 O O   . HOH T 5 .   ? -7.468  8.180   -5.794  1.00 39.66 ? 1704 HOH A O   1 ? 
HETATM 5078 O O   . HOH T 5 .   ? 9.053   -29.319 -3.557  1.00 45.67 ? 1705 HOH A O   1 ? 
HETATM 5079 O O   . HOH T 5 .   ? -5.711  9.985   0.519   1.00 43.38 ? 1706 HOH A O   1 ? 
HETATM 5080 O O   . HOH T 5 .   ? -10.624 4.460   -8.665  1.00 49.92 ? 1707 HOH A O   1 ? 
HETATM 5081 O O   . HOH T 5 .   ? -5.888  5.946   6.972   1.00 40.77 ? 1708 HOH A O   1 ? 
HETATM 5082 O O   . HOH T 5 .   ? 0.890   18.404  -6.964  1.00 51.06 ? 1709 HOH A O   1 ? 
HETATM 5083 O O   . HOH T 5 .   ? -6.979  -4.213  15.636  1.00 46.70 ? 1710 HOH A O   1 ? 
HETATM 5084 O O   . HOH T 5 .   ? -1.637  -7.363  16.213  1.00 59.90 ? 1711 HOH A O   1 ? 
HETATM 5085 O O   . HOH T 5 .   ? 25.792  -15.173 -16.235 1.00 49.99 ? 1712 HOH A O   1 ? 
HETATM 5086 O O   . HOH T 5 .   ? -8.417  -27.970 -10.208 1.00 38.12 ? 1713 HOH A O   1 ? 
HETATM 5087 O O   . HOH T 5 .   ? 6.731   -29.499 -4.462  1.00 49.62 ? 1714 HOH A O   1 ? 
HETATM 5088 O O   . HOH T 5 .   ? 12.903  -20.449 -27.294 1.00 35.06 ? 1715 HOH A O   1 ? 
HETATM 5089 O O   . HOH T 5 .   ? -6.879  -27.861 -24.362 1.00 45.74 ? 1716 HOH A O   1 ? 
HETATM 5090 O O   . HOH T 5 .   ? 23.216  -18.957 -12.808 1.00 38.61 ? 1717 HOH A O   1 ? 
HETATM 5091 O O   . HOH T 5 .   ? -24.343 -0.290  -14.088 1.00 45.43 ? 1718 HOH A O   1 ? 
HETATM 5092 O O   . HOH T 5 .   ? 5.828   -28.413 -10.482 1.00 46.42 ? 1719 HOH A O   1 ? 
HETATM 5093 O O   . HOH T 5 .   ? 9.855   -27.834 -26.327 1.00 41.01 ? 1720 HOH A O   1 ? 
HETATM 5094 O O   . HOH T 5 .   ? -5.695  -27.614 -13.200 1.00 38.17 ? 1721 HOH A O   1 ? 
HETATM 5095 O O   . HOH T 5 .   ? 24.489  -14.277 -20.644 1.00 35.36 ? 1722 HOH A O   1 ? 
HETATM 5096 O O   . HOH T 5 .   ? -0.935  3.279   8.609   1.00 30.27 ? 1723 HOH A O   1 ? 
HETATM 5097 O O   . HOH T 5 .   ? -8.326  -18.000 -29.733 1.00 41.05 ? 1724 HOH A O   1 ? 
HETATM 5098 O O   . HOH T 5 .   ? 21.856  -12.248 -7.103  1.00 44.38 ? 1725 HOH A O   1 ? 
HETATM 5099 O O   . HOH T 5 .   ? 10.527  1.434   -33.048 1.00 43.25 ? 1726 HOH A O   1 ? 
HETATM 5100 O O   . HOH T 5 .   ? 25.648  -10.586 -21.302 1.00 35.32 ? 1727 HOH A O   1 ? 
HETATM 5101 O O   . HOH T 5 .   ? 19.755  6.766   -11.159 1.00 38.67 ? 1728 HOH A O   1 ? 
HETATM 5102 O O   . HOH T 5 .   ? 26.156  2.905   -9.731  1.00 47.28 ? 1729 HOH A O   1 ? 
HETATM 5103 O O   . HOH T 5 .   ? 15.350  -22.152 -22.912 1.00 34.67 ? 1730 HOH A O   1 ? 
HETATM 5104 O O   . HOH T 5 .   ? -13.946 0.038   -7.939  1.00 43.32 ? 1731 HOH A O   1 ? 
HETATM 5105 O O   . HOH T 5 .   ? 11.932  -23.547 -23.674 1.00 34.95 ? 1732 HOH A O   1 ? 
HETATM 5106 O O   . HOH T 5 .   ? 6.270   -17.467 8.265   1.00 37.50 ? 1733 HOH A O   1 ? 
HETATM 5107 O O   . HOH T 5 .   ? 8.658   -15.091 8.069   1.00 35.91 ? 1734 HOH A O   1 ? 
HETATM 5108 O O   . HOH T 5 .   ? 7.931   -9.817  10.251  1.00 41.79 ? 1735 HOH A O   1 ? 
HETATM 5109 O O   . HOH T 5 .   ? -18.163 -19.477 -16.461 1.00 58.14 ? 1736 HOH A O   1 ? 
HETATM 5110 O O   . HOH T 5 .   ? 3.971   -11.348 13.360  1.00 48.97 ? 1737 HOH A O   1 ? 
HETATM 5111 O O   . HOH T 5 .   ? -8.510  -30.038 -20.596 1.00 49.86 ? 1738 HOH A O   1 ? 
HETATM 5112 O O   . HOH T 5 .   ? 15.199  -7.931  10.829  1.00 46.18 ? 1739 HOH A O   1 ? 
HETATM 5113 O O   . HOH T 5 .   ? -21.756 -0.566  -13.238 1.00 45.44 ? 1740 HOH A O   1 ? 
HETATM 5114 O O   . HOH T 5 .   ? 25.343  -11.186 -18.735 1.00 35.46 ? 1741 HOH A O   1 ? 
HETATM 5115 O O   . HOH T 5 .   ? -2.096  16.557  -2.372  1.00 47.92 ? 1742 HOH A O   1 ? 
HETATM 5116 O O   . HOH T 5 .   ? -5.949  15.245  4.371   1.00 53.19 ? 1743 HOH A O   1 ? 
HETATM 5117 O O   . HOH T 5 .   ? 22.767  -13.454 -9.129  1.00 37.09 ? 1744 HOH A O   1 ? 
HETATM 5118 O O   . HOH T 5 .   ? 10.463  5.043   -26.241 1.00 46.07 ? 1745 HOH A O   1 ? 
HETATM 5119 O O   . HOH T 5 .   ? 6.111   2.421   -31.535 1.00 45.57 ? 1746 HOH A O   1 ? 
HETATM 5120 O O   . HOH T 5 .   ? 23.135  -15.857 -10.079 1.00 29.93 ? 1747 HOH A O   1 ? 
HETATM 5121 O O   . HOH T 5 .   ? 4.615   -29.866 -11.907 1.00 46.63 ? 1748 HOH A O   1 ? 
HETATM 5122 O O   . HOH T 5 .   ? -14.837 -13.231 -19.693 1.00 38.17 ? 1749 HOH A O   1 ? 
HETATM 5123 O O   . HOH T 5 .   ? 6.798   -30.962 -20.832 1.00 44.87 ? 1750 HOH A O   1 ? 
HETATM 5124 O O   . HOH T 5 .   ? -13.558 -6.681  4.391   1.00 61.15 ? 1751 HOH A O   1 ? 
HETATM 5125 O O   . HOH T 5 .   ? -10.374 8.288   -6.202  1.00 53.63 ? 1752 HOH A O   1 ? 
HETATM 5126 O O   . HOH T 5 .   ? -1.283  -23.877 -30.552 1.00 50.76 ? 1753 HOH A O   1 ? 
HETATM 5127 O O   . HOH T 5 .   ? 6.256   -31.814 -12.459 1.00 50.33 ? 1754 HOH A O   1 ? 
HETATM 5128 O O   . HOH T 5 .   ? -14.822 -5.673  0.571   1.00 49.61 ? 1755 HOH A O   1 ? 
HETATM 5129 O O   . HOH T 5 .   ? -17.177 -22.724 -20.732 1.00 52.96 ? 1756 HOH A O   1 ? 
HETATM 5130 O O   . HOH T 5 .   ? -5.593  20.923  -0.380  1.00 58.19 ? 1757 HOH A O   1 ? 
HETATM 5131 O O   . HOH U 5 .   ? 25.314  28.293  -4.695  1.00 28.05 ? 1401 HOH B O   1 ? 
HETATM 5132 O O   . HOH U 5 .   ? 24.721  38.425  -14.857 1.00 36.36 ? 1402 HOH B O   1 ? 
HETATM 5133 O O   . HOH U 5 .   ? 39.487  34.263  -11.900 1.00 37.84 ? 1403 HOH B O   1 ? 
HETATM 5134 O O   . HOH U 5 .   ? 33.756  0.384   -38.454 1.00 29.70 ? 1404 HOH B O   1 ? 
HETATM 5135 O O   . HOH U 5 .   ? 24.562  0.922   -18.833 1.00 29.07 ? 1405 HOH B O   1 ? 
HETATM 5136 O O   . HOH U 5 .   ? 36.506  38.699  -34.767 1.00 49.23 ? 1406 HOH B O   1 ? 
HETATM 5137 O O   . HOH U 5 .   ? 23.040  26.924  -4.482  1.00 26.83 ? 1407 HOH B O   1 ? 
HETATM 5138 O O   . HOH U 5 .   ? 38.195  41.361  -17.753 1.00 45.36 ? 1408 HOH B O   1 ? 
HETATM 5139 O O   . HOH U 5 .   ? 38.356  20.778  -5.324  1.00 39.67 ? 1409 HOH B O   1 ? 
HETATM 5140 O O   . HOH U 5 .   ? 31.125  23.698  -4.444  1.00 32.35 ? 1410 HOH B O   1 ? 
HETATM 5141 O O   . HOH U 5 .   ? 6.636   28.348  -24.589 1.00 37.66 ? 1411 HOH B O   1 ? 
HETATM 5142 O O   . HOH U 5 .   ? 40.099  26.852  -7.650  1.00 31.99 ? 1412 HOH B O   1 ? 
HETATM 5143 O O   . HOH U 5 .   ? 18.122  17.144  -12.141 1.00 36.72 ? 1413 HOH B O   1 ? 
HETATM 5144 O O   . HOH U 5 .   ? 41.669  34.918  -16.556 1.00 38.68 ? 1414 HOH B O   1 ? 
HETATM 5145 O O   . HOH U 5 .   ? 11.117  31.878  -32.647 1.00 46.34 ? 1415 HOH B O   1 ? 
HETATM 5146 O O   . HOH U 5 .   ? 5.790   12.979  -22.404 1.00 30.14 ? 1416 HOH B O   1 ? 
HETATM 5147 O O   . HOH U 5 .   ? 19.442  16.566  -15.340 1.00 24.12 ? 1417 HOH B O   1 ? 
HETATM 5148 O O   . HOH U 5 .   ? 11.329  34.692  -38.808 1.00 30.55 ? 1418 HOH B O   1 ? 
HETATM 5149 O O   . HOH U 5 .   ? 42.996  25.207  -21.487 1.00 32.21 ? 1419 HOH B O   1 ? 
HETATM 5150 O O   . HOH U 5 .   ? 43.664  28.310  -34.727 1.00 49.04 ? 1420 HOH B O   1 ? 
HETATM 5151 O O   . HOH U 5 .   ? 6.334   25.061  -19.608 1.00 48.61 ? 1421 HOH B O   1 ? 
HETATM 5152 O O   . HOH U 5 .   ? 45.541  8.970   -23.412 1.00 37.58 ? 1422 HOH B O   1 ? 
HETATM 5153 O O   . HOH U 5 .   ? 24.216  38.183  -40.781 1.00 22.62 ? 1423 HOH B O   1 ? 
HETATM 5154 O O   . HOH U 5 .   ? 42.256  28.384  -26.014 1.00 27.77 ? 1424 HOH B O   1 ? 
HETATM 5155 O O   . HOH U 5 .   ? 12.985  31.259  -9.046  1.00 41.12 ? 1425 HOH B O   1 ? 
HETATM 5156 O O   . HOH U 5 .   ? 11.208  11.019  -13.771 1.00 37.82 ? 1426 HOH B O   1 ? 
HETATM 5157 O O   . HOH U 5 .   ? 35.120  5.180   -35.825 1.00 36.33 ? 1427 HOH B O   1 ? 
HETATM 5158 O O   . HOH U 5 .   ? 9.999   39.531  -33.616 1.00 47.63 ? 1428 HOH B O   1 ? 
HETATM 5159 O O   . HOH U 5 .   ? 28.555  26.025  -3.203  1.00 39.29 ? 1429 HOH B O   1 ? 
HETATM 5160 O O   . HOH U 5 .   ? 22.919  43.159  -19.008 1.00 32.30 ? 1430 HOH B O   1 ? 
HETATM 5161 O O   . HOH U 5 .   ? 24.836  2.817   -29.495 1.00 50.00 ? 1431 HOH B O   1 ? 
HETATM 5162 O O   . HOH U 5 .   ? 19.027  18.833  -17.576 1.00 16.19 ? 1432 HOH B O   1 ? 
HETATM 5163 O O   . HOH U 5 .   ? 28.772  15.397  -45.711 1.00 40.38 ? 1433 HOH B O   1 ? 
HETATM 5164 O O   . HOH U 5 .   ? 19.656  20.549  -10.503 1.00 40.40 ? 1434 HOH B O   1 ? 
HETATM 5165 O O   . HOH U 5 .   ? 43.542  29.539  -20.022 1.00 42.43 ? 1435 HOH B O   1 ? 
HETATM 5166 O O   . HOH U 5 .   ? 37.485  13.914  -20.367 1.00 22.99 ? 1436 HOH B O   1 ? 
HETATM 5167 O O   . HOH U 5 .   ? 45.152  16.560  -34.125 1.00 44.22 ? 1437 HOH B O   1 ? 
HETATM 5168 O O   . HOH U 5 .   ? 37.282  23.132  -5.738  1.00 41.48 ? 1438 HOH B O   1 ? 
HETATM 5169 O O   . HOH U 5 .   ? 24.141  36.081  -12.800 1.00 36.49 ? 1439 HOH B O   1 ? 
HETATM 5170 O O   . HOH U 5 .   ? 31.616  17.836  -31.232 1.00 20.65 ? 1440 HOH B O   1 ? 
HETATM 5171 O O   . HOH U 5 .   ? 11.958  32.919  -36.492 1.00 36.95 ? 1441 HOH B O   1 ? 
HETATM 5172 O O   . HOH U 5 .   ? 14.064  16.595  -40.759 1.00 19.71 ? 1442 HOH B O   1 ? 
HETATM 5173 O O   . HOH U 5 .   ? 6.999   12.480  -24.432 1.00 31.35 ? 1443 HOH B O   1 ? 
HETATM 5174 O O   . HOH U 5 .   ? 15.574  18.592  -44.912 1.00 39.21 ? 1444 HOH B O   1 ? 
HETATM 5175 O O   . HOH U 5 .   ? 23.105  27.412  -49.797 1.00 20.07 ? 1445 HOH B O   1 ? 
HETATM 5176 O O   . HOH U 5 .   ? 37.653  42.983  -15.178 1.00 47.28 ? 1446 HOH B O   1 ? 
HETATM 5177 O O   . HOH U 5 .   ? 24.657  0.043   -32.441 1.00 41.25 ? 1447 HOH B O   1 ? 
HETATM 5178 O O   . HOH U 5 .   ? 27.767  18.416  -9.814  1.00 44.98 ? 1448 HOH B O   1 ? 
HETATM 5179 O O   . HOH U 5 .   ? 6.451   20.807  -22.005 1.00 26.09 ? 1449 HOH B O   1 ? 
HETATM 5180 O O   . HOH U 5 .   ? 23.136  22.543  -19.718 1.00 14.55 ? 1450 HOH B O   1 ? 
HETATM 5181 O O   . HOH U 5 .   ? 21.948  37.360  -41.258 1.00 17.34 ? 1451 HOH B O   1 ? 
HETATM 5182 O O   . HOH U 5 .   ? 12.657  8.613   -13.564 1.00 36.59 ? 1452 HOH B O   1 ? 
HETATM 5183 O O   . HOH U 5 .   ? 29.565  39.139  -32.480 1.00 30.79 ? 1453 HOH B O   1 ? 
HETATM 5184 O O   . HOH U 5 .   ? 26.462  13.797  -47.299 1.00 46.13 ? 1454 HOH B O   1 ? 
HETATM 5185 O O   . HOH U 5 .   ? 18.130  7.959   -42.870 1.00 27.02 ? 1455 HOH B O   1 ? 
HETATM 5186 O O   . HOH U 5 .   ? 11.288  31.295  -21.097 1.00 24.81 ? 1456 HOH B O   1 ? 
HETATM 5187 O O   . HOH U 5 .   ? 20.962  32.897  -49.322 1.00 24.22 ? 1457 HOH B O   1 ? 
HETATM 5188 O O   . HOH U 5 .   ? 35.037  -2.356  -25.179 1.00 16.48 ? 1458 HOH B O   1 ? 
HETATM 5189 O O   . HOH U 5 .   ? 15.022  44.277  -26.532 1.00 37.55 ? 1459 HOH B O   1 ? 
HETATM 5190 O O   . HOH U 5 .   ? 13.290  4.491   -33.196 1.00 28.98 ? 1460 HOH B O   1 ? 
HETATM 5191 O O   . HOH U 5 .   ? 23.145  13.593  -40.145 1.00 17.68 ? 1461 HOH B O   1 ? 
HETATM 5192 O O   . HOH U 5 .   ? 17.682  10.538  -46.580 1.00 44.53 ? 1462 HOH B O   1 ? 
HETATM 5193 O O   . HOH U 5 .   ? 26.519  17.367  -35.965 1.00 13.73 ? 1463 HOH B O   1 ? 
HETATM 5194 O O   . HOH U 5 .   ? 11.412  27.152  -10.981 1.00 53.27 ? 1464 HOH B O   1 ? 
HETATM 5195 O O   . HOH U 5 .   ? 41.294  14.692  -35.895 1.00 34.33 ? 1465 HOH B O   1 ? 
HETATM 5196 O O   . HOH U 5 .   ? 15.070  22.444  -29.108 1.00 14.41 ? 1466 HOH B O   1 ? 
HETATM 5197 O O   . HOH U 5 .   ? 28.300  11.266  -13.548 1.00 37.35 ? 1467 HOH B O   1 ? 
HETATM 5198 O O   . HOH U 5 .   ? 25.173  5.268   -13.121 1.00 31.30 ? 1468 HOH B O   1 ? 
HETATM 5199 O O   . HOH U 5 .   ? 15.377  45.034  -29.115 1.00 55.65 ? 1469 HOH B O   1 ? 
HETATM 5200 O O   . HOH U 5 .   ? 11.877  2.831   -15.812 1.00 20.84 ? 1470 HOH B O   1 ? 
HETATM 5201 O O   . HOH U 5 .   ? 37.243  7.039   -36.137 1.00 24.87 ? 1471 HOH B O   1 ? 
HETATM 5202 O O   . HOH U 5 .   ? 24.987  4.674   -27.682 1.00 24.52 ? 1472 HOH B O   1 ? 
HETATM 5203 O O   . HOH U 5 .   ? 14.914  21.210  -14.486 1.00 33.18 ? 1473 HOH B O   1 ? 
HETATM 5204 O O   . HOH U 5 .   ? 22.206  4.996   -38.157 1.00 19.75 ? 1474 HOH B O   1 ? 
HETATM 5205 O O   . HOH U 5 .   ? 30.876  5.332   -46.204 1.00 34.40 ? 1475 HOH B O   1 ? 
HETATM 5206 O O   . HOH U 5 .   ? 17.508  20.216  -32.008 1.00 14.68 ? 1476 HOH B O   1 ? 
HETATM 5207 O O   . HOH U 5 .   ? 34.025  15.066  -19.662 1.00 20.78 ? 1477 HOH B O   1 ? 
HETATM 5208 O O   . HOH U 5 .   ? 22.582  1.985   -17.529 1.00 26.81 ? 1478 HOH B O   1 ? 
HETATM 5209 O O   . HOH U 5 .   ? 11.244  12.065  -35.565 1.00 23.80 ? 1479 HOH B O   1 ? 
HETATM 5210 O O   . HOH U 5 .   ? 27.598  3.570   -19.435 1.00 35.41 ? 1480 HOH B O   1 ? 
HETATM 5211 O O   . HOH U 5 .   ? 37.925  17.504  -42.485 1.00 39.21 ? 1481 HOH B O   1 ? 
HETATM 5212 O O   . HOH U 5 .   ? 7.653   8.466   -27.416 1.00 34.88 ? 1482 HOH B O   1 ? 
HETATM 5213 O O   . HOH U 5 .   ? 18.750  29.423  -44.371 1.00 24.91 ? 1483 HOH B O   1 ? 
HETATM 5214 O O   . HOH U 5 .   ? 4.486   22.449  -32.158 1.00 44.17 ? 1484 HOH B O   1 ? 
HETATM 5215 O O   . HOH U 5 .   ? 16.521  40.095  -19.067 1.00 31.46 ? 1485 HOH B O   1 ? 
HETATM 5216 O O   . HOH U 5 .   ? 20.313  8.462   -44.486 1.00 24.06 ? 1486 HOH B O   1 ? 
HETATM 5217 O O   . HOH U 5 .   ? 28.726  33.275  -43.933 1.00 19.37 ? 1487 HOH B O   1 ? 
HETATM 5218 O O   . HOH U 5 .   ? 15.561  26.877  -9.971  1.00 36.10 ? 1488 HOH B O   1 ? 
HETATM 5219 O O   . HOH U 5 .   ? 9.931   26.202  -40.905 1.00 39.85 ? 1489 HOH B O   1 ? 
HETATM 5220 O O   . HOH U 5 .   ? 38.764  26.721  -38.271 1.00 25.30 ? 1490 HOH B O   1 ? 
HETATM 5221 O O   . HOH U 5 .   ? 38.195  0.791   -32.226 1.00 27.63 ? 1491 HOH B O   1 ? 
HETATM 5222 O O   . HOH U 5 .   ? 8.938   12.008  -39.819 1.00 33.43 ? 1492 HOH B O   1 ? 
HETATM 5223 O O   . HOH U 5 .   ? 11.512  1.514   -22.027 1.00 27.97 ? 1493 HOH B O   1 ? 
HETATM 5224 O O   . HOH U 5 .   ? 32.501  31.865  -37.401 1.00 18.17 ? 1494 HOH B O   1 ? 
HETATM 5225 O O   . HOH U 5 .   ? 37.216  7.163   -39.064 1.00 36.73 ? 1495 HOH B O   1 ? 
HETATM 5226 O O   . HOH U 5 .   ? 26.922  11.259  -34.545 1.00 16.56 ? 1496 HOH B O   1 ? 
HETATM 5227 O O   . HOH U 5 .   ? 38.206  32.143  -10.582 1.00 32.32 ? 1497 HOH B O   1 ? 
HETATM 5228 O O   . HOH U 5 .   ? 21.114  11.969  -15.010 1.00 25.01 ? 1498 HOH B O   1 ? 
HETATM 5229 O O   . HOH U 5 .   ? 13.714  17.336  -38.053 1.00 18.50 ? 1499 HOH B O   1 ? 
HETATM 5230 O O   . HOH U 5 .   ? 12.100  25.984  -15.382 1.00 37.38 ? 1500 HOH B O   1 ? 
HETATM 5231 O O   . HOH U 5 .   ? 25.104  40.797  -30.475 1.00 45.55 ? 1501 HOH B O   1 ? 
HETATM 5232 O O   . HOH U 5 .   ? 10.492  34.164  -29.037 1.00 27.17 ? 1502 HOH B O   1 ? 
HETATM 5233 O O   . HOH U 5 .   ? 14.341  18.598  -22.960 1.00 23.33 ? 1503 HOH B O   1 ? 
HETATM 5234 O O   . HOH U 5 .   ? 9.132   23.617  -40.399 1.00 29.44 ? 1504 HOH B O   1 ? 
HETATM 5235 O O   . HOH U 5 .   ? 12.019  19.837  -23.052 1.00 17.16 ? 1505 HOH B O   1 ? 
HETATM 5236 O O   . HOH U 5 .   ? 44.934  19.896  -33.637 1.00 46.25 ? 1506 HOH B O   1 ? 
HETATM 5237 O O   . HOH U 5 .   ? 27.037  1.580   -30.575 1.00 30.31 ? 1507 HOH B O   1 ? 
HETATM 5238 O O   . HOH U 5 .   ? 23.992  37.309  -38.791 1.00 22.83 ? 1508 HOH B O   1 ? 
HETATM 5239 O O   . HOH U 5 .   ? 40.838  23.447  -20.923 1.00 21.06 ? 1509 HOH B O   1 ? 
HETATM 5240 O O   . HOH U 5 .   ? 6.322   13.511  -33.515 1.00 33.70 ? 1510 HOH B O   1 ? 
HETATM 5241 O O   . HOH U 5 .   ? 17.449  43.934  -29.919 1.00 38.14 ? 1511 HOH B O   1 ? 
HETATM 5242 O O   . HOH U 5 .   ? 30.556  9.150   -33.408 1.00 23.61 ? 1512 HOH B O   1 ? 
HETATM 5243 O O   . HOH U 5 .   ? 18.706  7.263   -13.786 1.00 22.62 ? 1513 HOH B O   1 ? 
HETATM 5244 O O   . HOH U 5 .   ? 6.245   12.146  -30.794 1.00 26.70 ? 1514 HOH B O   1 ? 
HETATM 5245 O O   . HOH U 5 .   ? 4.316   21.025  -25.451 1.00 38.66 ? 1515 HOH B O   1 ? 
HETATM 5246 O O   . HOH U 5 .   ? 43.897  23.625  -30.846 1.00 27.21 ? 1516 HOH B O   1 ? 
HETATM 5247 O O   . HOH U 5 .   ? 25.027  28.296  -47.977 1.00 16.34 ? 1517 HOH B O   1 ? 
HETATM 5248 O O   . HOH U 5 .   ? 19.837  13.660  -37.754 1.00 15.80 ? 1518 HOH B O   1 ? 
HETATM 5249 O O   . HOH U 5 .   ? 26.403  38.212  -40.160 1.00 35.37 ? 1519 HOH B O   1 ? 
HETATM 5250 O O   . HOH U 5 .   ? 24.194  38.397  -34.145 1.00 26.47 ? 1520 HOH B O   1 ? 
HETATM 5251 O O   . HOH U 5 .   ? 27.430  0.138   -37.646 1.00 38.50 ? 1521 HOH B O   1 ? 
HETATM 5252 O O   . HOH U 5 .   ? 19.745  25.705  -7.967  1.00 41.23 ? 1522 HOH B O   1 ? 
HETATM 5253 O O   . HOH U 5 .   ? 34.433  23.075  -43.305 1.00 18.87 ? 1523 HOH B O   1 ? 
HETATM 5254 O O   . HOH U 5 .   ? 44.563  26.858  -12.831 1.00 45.87 ? 1524 HOH B O   1 ? 
HETATM 5255 O O   . HOH U 5 .   ? 36.996  20.323  -7.612  1.00 30.15 ? 1525 HOH B O   1 ? 
HETATM 5256 O O   . HOH U 5 .   ? 29.071  39.272  -19.504 1.00 36.46 ? 1526 HOH B O   1 ? 
HETATM 5257 O O   . HOH U 5 .   ? 25.265  39.247  -31.764 1.00 26.34 ? 1527 HOH B O   1 ? 
HETATM 5258 O O   . HOH U 5 .   ? 43.354  30.005  -22.557 1.00 41.98 ? 1528 HOH B O   1 ? 
HETATM 5259 O O   . HOH U 5 .   ? 10.043  7.105   -27.796 1.00 31.91 ? 1529 HOH B O   1 ? 
HETATM 5260 O O   . HOH U 5 .   ? 43.552  18.574  -10.043 1.00 42.69 ? 1530 HOH B O   1 ? 
HETATM 5261 O O   . HOH U 5 .   ? 7.880   25.386  -30.795 1.00 20.80 ? 1531 HOH B O   1 ? 
HETATM 5262 O O   . HOH U 5 .   ? 27.035  33.979  -45.813 1.00 24.09 ? 1532 HOH B O   1 ? 
HETATM 5263 O O   . HOH U 5 .   ? 23.911  41.826  -29.666 1.00 33.75 ? 1533 HOH B O   1 ? 
HETATM 5264 O O   . HOH U 5 .   ? 19.253  13.083  -16.871 1.00 21.19 ? 1534 HOH B O   1 ? 
HETATM 5265 O O   . HOH U 5 .   ? 31.999  41.171  -28.731 1.00 25.99 ? 1535 HOH B O   1 ? 
HETATM 5266 O O   . HOH U 5 .   ? 20.522  12.640  -40.154 1.00 16.52 ? 1536 HOH B O   1 ? 
HETATM 5267 O O   . HOH U 5 .   ? 28.743  38.347  -16.794 1.00 40.73 ? 1537 HOH B O   1 ? 
HETATM 5268 O O   . HOH U 5 .   ? 43.999  22.098  -12.512 1.00 49.61 ? 1538 HOH B O   1 ? 
HETATM 5269 O O   . HOH U 5 .   ? 17.987  17.227  -45.394 1.00 25.10 ? 1539 HOH B O   1 ? 
HETATM 5270 O O   . HOH U 5 .   ? 26.022  -1.933  -22.917 1.00 35.27 ? 1540 HOH B O   1 ? 
HETATM 5271 O O   . HOH U 5 .   ? 23.464  -0.178  -23.408 1.00 33.12 ? 1541 HOH B O   1 ? 
HETATM 5272 O O   . HOH U 5 .   ? 10.585  9.965   -33.919 1.00 24.40 ? 1542 HOH B O   1 ? 
HETATM 5273 O O   . HOH U 5 .   ? 27.966  23.119  -45.479 1.00 19.85 ? 1543 HOH B O   1 ? 
HETATM 5274 O O   . HOH U 5 .   ? 27.845  -0.839  -30.587 1.00 20.18 ? 1544 HOH B O   1 ? 
HETATM 5275 O O   . HOH U 5 .   ? 43.723  13.505  -35.100 1.00 47.66 ? 1545 HOH B O   1 ? 
HETATM 5276 O O   . HOH U 5 .   ? 12.403  40.696  -32.957 1.00 33.02 ? 1546 HOH B O   1 ? 
HETATM 5277 O O   . HOH U 5 .   ? 27.038  35.947  -37.924 1.00 20.39 ? 1547 HOH B O   1 ? 
HETATM 5278 O O   . HOH U 5 .   ? 21.153  -0.217  -17.017 1.00 31.85 ? 1548 HOH B O   1 ? 
HETATM 5279 O O   . HOH U 5 .   ? 44.996  0.024   -33.201 1.00 44.18 ? 1549 HOH B O   1 ? 
HETATM 5280 O O   . HOH U 5 .   ? 28.368  36.235  -15.475 1.00 37.16 ? 1550 HOH B O   1 ? 
HETATM 5281 O O   . HOH U 5 .   ? 32.804  13.834  -17.460 1.00 23.14 ? 1551 HOH B O   1 ? 
HETATM 5282 O O   . HOH U 5 .   ? 19.587  16.298  -23.439 1.00 13.28 ? 1552 HOH B O   1 ? 
HETATM 5283 O O   . HOH U 5 .   ? 28.601  25.611  -46.323 1.00 17.65 ? 1553 HOH B O   1 ? 
HETATM 5284 O O   . HOH U 5 .   ? 31.758  16.477  -19.150 1.00 17.73 ? 1554 HOH B O   1 ? 
HETATM 5285 O O   . HOH U 5 .   ? 35.781  9.374   -41.083 1.00 38.62 ? 1555 HOH B O   1 ? 
HETATM 5286 O O   . HOH U 5 .   ? 15.229  10.020  -13.960 1.00 25.97 ? 1556 HOH B O   1 ? 
HETATM 5287 O O   . HOH U 5 .   ? 33.168  22.924  -6.046  1.00 31.07 ? 1557 HOH B O   1 ? 
HETATM 5288 O O   . HOH U 5 .   ? 3.288   20.251  -34.388 1.00 32.48 ? 1558 HOH B O   1 ? 
HETATM 5289 O O   . HOH U 5 .   ? 13.674  17.235  -16.225 1.00 24.60 ? 1559 HOH B O   1 ? 
HETATM 5290 O O   . HOH U 5 .   ? 28.840  -4.537  -23.435 1.00 23.34 ? 1560 HOH B O   1 ? 
HETATM 5291 O O   . HOH U 5 .   ? 24.665  33.974  -9.295  1.00 26.18 ? 1561 HOH B O   1 ? 
HETATM 5292 O O   . HOH U 5 .   ? 44.348  14.274  -23.766 1.00 36.49 ? 1562 HOH B O   1 ? 
HETATM 5293 O O   . HOH U 5 .   ? 22.211  11.396  -17.607 1.00 17.55 ? 1563 HOH B O   1 ? 
HETATM 5294 O O   . HOH U 5 .   ? 29.539  -5.244  -26.017 1.00 19.51 ? 1564 HOH B O   1 ? 
HETATM 5295 O O   . HOH U 5 .   ? 23.677  -5.808  -24.790 1.00 19.16 ? 1565 HOH B O   1 ? 
HETATM 5296 O O   . HOH U 5 .   ? 1.385   13.145  -34.025 1.00 50.86 ? 1566 HOH B O   1 ? 
HETATM 5297 O O   . HOH U 5 .   ? 19.510  2.322   -35.566 1.00 28.85 ? 1567 HOH B O   1 ? 
HETATM 5298 O O   . HOH U 5 .   ? 22.855  -2.807  -25.495 1.00 26.73 ? 1568 HOH B O   1 ? 
HETATM 5299 O O   . HOH U 5 .   ? 12.055  9.803   -39.751 1.00 35.32 ? 1569 HOH B O   1 ? 
HETATM 5300 O O   . HOH U 5 .   ? 21.343  23.119  -9.552  1.00 38.63 ? 1570 HOH B O   1 ? 
HETATM 5301 O O   . HOH U 5 .   ? 31.657  28.285  -8.743  1.00 21.91 ? 1571 HOH B O   1 ? 
HETATM 5302 O O   . HOH U 5 .   ? 29.199  -0.738  -33.030 1.00 24.75 ? 1572 HOH B O   1 ? 
HETATM 5303 O O   . HOH U 5 .   ? 46.978  7.704   -27.342 1.00 31.09 ? 1573 HOH B O   1 ? 
HETATM 5304 O O   . HOH U 5 .   ? 35.746  17.259  -21.441 1.00 43.46 ? 1574 HOH B O   1 ? 
HETATM 5305 O O   . HOH U 5 .   ? 31.536  15.684  -15.941 1.00 17.88 ? 1575 HOH B O   1 ? 
HETATM 5306 O O   . HOH U 5 .   ? 45.507  14.479  -20.231 1.00 51.80 ? 1576 HOH B O   1 ? 
HETATM 5307 O O   . HOH U 5 .   ? 25.366  26.615  -3.481  1.00 37.22 ? 1577 HOH B O   1 ? 
HETATM 5308 O O   . HOH U 5 .   ? 30.440  13.023  -13.406 1.00 39.02 ? 1578 HOH B O   1 ? 
HETATM 5309 O O   . HOH U 5 .   ? 13.078  14.781  -16.240 1.00 33.98 ? 1579 HOH B O   1 ? 
HETATM 5310 O O   . HOH U 5 .   ? 21.546  40.736  -31.408 1.00 39.53 ? 1580 HOH B O   1 ? 
HETATM 5311 O O   . HOH U 5 .   ? 31.168  5.172   -13.138 1.00 46.16 ? 1581 HOH B O   1 ? 
HETATM 5312 O O   . HOH U 5 .   ? 27.538  1.454   -33.671 1.00 37.43 ? 1582 HOH B O   1 ? 
HETATM 5313 O O   . HOH U 5 .   ? 41.010  17.138  -38.934 1.00 33.27 ? 1583 HOH B O   1 ? 
HETATM 5314 O O   . HOH U 5 .   ? 13.657  24.169  -15.096 1.00 37.13 ? 1584 HOH B O   1 ? 
HETATM 5315 O O   . HOH U 5 .   ? 17.264  30.165  -42.131 1.00 22.37 ? 1585 HOH B O   1 ? 
HETATM 5316 O O   . HOH U 5 .   ? 36.697  40.592  -21.832 1.00 46.38 ? 1586 HOH B O   1 ? 
HETATM 5317 O O   . HOH U 5 .   ? 41.157  20.204  -16.846 1.00 30.00 ? 1587 HOH B O   1 ? 
HETATM 5318 O O   . HOH U 5 .   ? 30.645  31.426  -43.137 1.00 18.26 ? 1588 HOH B O   1 ? 
HETATM 5319 O O   . HOH U 5 .   ? 46.354  17.625  -26.788 1.00 45.30 ? 1589 HOH B O   1 ? 
HETATM 5320 O O   . HOH U 5 .   ? 36.104  -0.955  -31.822 1.00 28.04 ? 1590 HOH B O   1 ? 
HETATM 5321 O O   . HOH U 5 .   ? 48.626  0.624   -29.680 1.00 60.30 ? 1591 HOH B O   1 ? 
HETATM 5322 O O   . HOH U 5 .   ? 12.033  30.291  -37.017 1.00 20.44 ? 1592 HOH B O   1 ? 
HETATM 5323 O O   . HOH U 5 .   ? 26.613  24.421  -4.450  1.00 32.81 ? 1593 HOH B O   1 ? 
HETATM 5324 O O   . HOH U 5 .   ? 18.162  36.357  -9.123  1.00 33.68 ? 1594 HOH B O   1 ? 
HETATM 5325 O O   . HOH U 5 .   ? 8.355   28.358  -18.752 1.00 45.52 ? 1595 HOH B O   1 ? 
HETATM 5326 O O   . HOH U 5 .   ? 46.254  28.539  -33.176 1.00 57.44 ? 1596 HOH B O   1 ? 
HETATM 5327 O O   . HOH U 5 .   ? 11.441  28.660  -17.802 1.00 43.60 ? 1597 HOH B O   1 ? 
HETATM 5328 O O   . HOH U 5 .   ? 1.916   17.151  -35.464 1.00 42.03 ? 1598 HOH B O   1 ? 
HETATM 5329 O O   . HOH U 5 .   ? 15.907  32.179  -43.247 1.00 23.05 ? 1599 HOH B O   1 ? 
HETATM 5330 O O   . HOH U 5 .   ? 23.194  3.095   -31.565 1.00 40.92 ? 1600 HOH B O   1 ? 
HETATM 5331 O O   . HOH U 5 .   ? 13.147  25.849  -10.190 1.00 42.13 ? 1601 HOH B O   1 ? 
HETATM 5332 O O   . HOH U 5 .   ? 24.993  17.374  -46.667 1.00 45.09 ? 1602 HOH B O   1 ? 
HETATM 5333 O O   . HOH U 5 .   ? 7.388   22.215  -15.519 1.00 38.47 ? 1603 HOH B O   1 ? 
HETATM 5334 O O   . HOH U 5 .   ? 8.793   26.205  -33.285 1.00 22.11 ? 1604 HOH B O   1 ? 
HETATM 5335 O O   . HOH U 5 .   ? 25.327  2.440   -20.603 1.00 28.37 ? 1605 HOH B O   1 ? 
HETATM 5336 O O   . HOH U 5 .   ? 4.220   16.379  -19.988 1.00 47.25 ? 1606 HOH B O   1 ? 
HETATM 5337 O O   . HOH U 5 .   ? 23.559  16.520  -11.827 1.00 30.87 ? 1607 HOH B O   1 ? 
HETATM 5338 O O   . HOH U 5 .   ? 16.209  23.348  -44.270 1.00 39.58 ? 1608 HOH B O   1 ? 
HETATM 5339 O O   . HOH U 5 .   ? 22.732  25.152  -2.566  1.00 42.80 ? 1609 HOH B O   1 ? 
HETATM 5340 O O   . HOH U 5 .   ? 25.350  3.705   -31.966 1.00 43.94 ? 1610 HOH B O   1 ? 
HETATM 5341 O O   . HOH U 5 .   ? 33.013  15.438  -13.626 1.00 32.80 ? 1611 HOH B O   1 ? 
HETATM 5342 O O   . HOH U 5 .   ? 37.267  25.679  -40.637 1.00 24.52 ? 1612 HOH B O   1 ? 
HETATM 5343 O O   . HOH U 5 .   ? 20.408  -2.782  -27.704 1.00 32.20 ? 1613 HOH B O   1 ? 
HETATM 5344 O O   . HOH U 5 .   ? 25.299  44.932  -19.678 1.00 50.42 ? 1614 HOH B O   1 ? 
HETATM 5345 O O   . HOH U 5 .   ? 35.728  32.969  -36.508 1.00 32.87 ? 1615 HOH B O   1 ? 
HETATM 5346 O O   . HOH U 5 .   ? 35.802  41.061  -30.603 1.00 44.49 ? 1616 HOH B O   1 ? 
HETATM 5347 O O   . HOH U 5 .   ? 16.111  18.126  -15.454 1.00 33.60 ? 1617 HOH B O   1 ? 
HETATM 5348 O O   . HOH U 5 .   ? 37.534  29.072  -9.074  1.00 44.23 ? 1618 HOH B O   1 ? 
HETATM 5349 O O   . HOH U 5 .   ? 6.237   23.843  -21.800 1.00 39.02 ? 1619 HOH B O   1 ? 
HETATM 5350 O O   . HOH U 5 .   ? 16.364  33.587  -9.590  1.00 33.93 ? 1620 HOH B O   1 ? 
HETATM 5351 O O   . HOH U 5 .   ? 35.043  7.530   -10.463 1.00 52.23 ? 1621 HOH B O   1 ? 
HETATM 5352 O O   . HOH U 5 .   ? 26.872  40.846  -28.724 1.00 28.30 ? 1622 HOH B O   1 ? 
HETATM 5353 O O   . HOH U 5 .   ? 28.277  37.520  -41.106 1.00 44.52 ? 1623 HOH B O   1 ? 
HETATM 5354 O O   . HOH U 5 .   ? 12.183  33.089  -11.193 1.00 41.32 ? 1624 HOH B O   1 ? 
HETATM 5355 O O   . HOH U 5 .   ? 15.648  40.431  -21.807 1.00 44.32 ? 1625 HOH B O   1 ? 
HETATM 5356 O O   . HOH U 5 .   ? 6.186   20.321  -19.281 1.00 39.90 ? 1626 HOH B O   1 ? 
HETATM 5357 O O   . HOH U 5 .   ? 21.353  2.124   -37.300 1.00 35.67 ? 1627 HOH B O   1 ? 
HETATM 5358 O O   . HOH U 5 .   ? 33.998  21.115  -6.613  1.00 54.07 ? 1628 HOH B O   1 ? 
HETATM 5359 O O   . HOH U 5 .   ? 34.115  13.197  -44.212 1.00 36.24 ? 1629 HOH B O   1 ? 
HETATM 5360 O O   . HOH U 5 .   ? 10.746  6.185   -32.504 1.00 47.85 ? 1630 HOH B O   1 ? 
HETATM 5361 O O   . HOH U 5 .   ? 43.701  26.503  -30.755 1.00 42.71 ? 1631 HOH B O   1 ? 
HETATM 5362 O O   . HOH U 5 .   ? 18.925  -0.480  -29.078 1.00 46.66 ? 1632 HOH B O   1 ? 
HETATM 5363 O O   . HOH U 5 .   ? 26.392  1.704   -17.440 1.00 32.49 ? 1633 HOH B O   1 ? 
HETATM 5364 O O   . HOH U 5 .   ? 40.840  23.422  -35.989 1.00 46.66 ? 1634 HOH B O   1 ? 
HETATM 5365 O O   . HOH U 5 .   ? 46.594  20.859  -27.717 1.00 49.68 ? 1635 HOH B O   1 ? 
HETATM 5366 O O   . HOH U 5 .   ? 43.268  21.140  -15.195 1.00 49.14 ? 1636 HOH B O   1 ? 
HETATM 5367 O O   . HOH U 5 .   ? 48.802  18.657  -31.329 1.00 38.09 ? 1637 HOH B O   1 ? 
HETATM 5368 O O   . HOH U 5 .   ? 24.532  2.445   -15.684 1.00 36.33 ? 1638 HOH B O   1 ? 
HETATM 5369 O O   . HOH U 5 .   ? 5.403   24.468  -31.340 1.00 44.60 ? 1639 HOH B O   1 ? 
HETATM 5370 O O   . HOH U 5 .   ? 8.481   36.107  -29.863 1.00 47.71 ? 1640 HOH B O   1 ? 
HETATM 5371 O O   . HOH U 5 .   ? 41.584  21.486  -19.190 1.00 45.20 ? 1641 HOH B O   1 ? 
HETATM 5372 O O   . HOH U 5 .   ? 29.465  -0.410  -36.771 1.00 29.58 ? 1642 HOH B O   1 ? 
HETATM 5373 O O   . HOH U 5 .   ? 12.650  34.357  -25.685 1.00 41.37 ? 1643 HOH B O   1 ? 
HETATM 5374 O O   . HOH U 5 .   ? 38.347  23.641  -40.862 1.00 41.53 ? 1644 HOH B O   1 ? 
HETATM 5375 O O   . HOH U 5 .   ? 20.755  9.228   -13.643 1.00 39.33 ? 1645 HOH B O   1 ? 
HETATM 5376 O O   . HOH U 5 .   ? 12.545  24.148  -11.396 1.00 43.15 ? 1646 HOH B O   1 ? 
HETATM 5377 O O   . HOH U 5 .   ? 2.882   17.683  -37.977 1.00 63.85 ? 1647 HOH B O   1 ? 
HETATM 5378 O O   . HOH U 5 .   ? 41.340  30.165  -36.912 1.00 41.35 ? 1648 HOH B O   1 ? 
HETATM 5379 O O   . HOH U 5 .   ? 9.423   5.916   -30.217 1.00 42.57 ? 1649 HOH B O   1 ? 
HETATM 5380 O O   . HOH U 5 .   ? 42.869  23.871  -5.709  1.00 47.14 ? 1650 HOH B O   1 ? 
HETATM 5381 O O   . HOH U 5 .   ? 8.666   32.060  -35.857 1.00 47.83 ? 1651 HOH B O   1 ? 
HETATM 5382 O O   . HOH U 5 .   ? 22.498  40.453  -37.954 1.00 44.92 ? 1652 HOH B O   1 ? 
HETATM 5383 O O   . HOH U 5 .   ? 9.593   24.919  -14.481 1.00 49.53 ? 1653 HOH B O   1 ? 
HETATM 5384 O O   . HOH U 5 .   ? 21.386  1.531   -32.701 1.00 35.46 ? 1654 HOH B O   1 ? 
HETATM 5385 O O   . HOH U 5 .   ? 17.189  13.639  -15.081 1.00 28.66 ? 1655 HOH B O   1 ? 
HETATM 5386 O O   . HOH U 5 .   ? 8.701   21.353  -13.729 1.00 42.41 ? 1656 HOH B O   1 ? 
HETATM 5387 O O   . HOH U 5 .   ? 29.132  36.096  -43.002 1.00 40.39 ? 1657 HOH B O   1 ? 
HETATM 5388 O O   . HOH U 5 .   ? 2.266   22.894  -31.381 1.00 45.60 ? 1658 HOH B O   1 ? 
HETATM 5389 O O   . HOH U 5 .   ? 15.521  42.704  -24.605 1.00 40.43 ? 1659 HOH B O   1 ? 
HETATM 5390 O O   . HOH U 5 .   ? 38.899  21.321  -39.106 1.00 42.06 ? 1660 HOH B O   1 ? 
HETATM 5391 O O   . HOH U 5 .   ? 32.211  33.227  -42.669 1.00 29.41 ? 1661 HOH B O   1 ? 
HETATM 5392 O O   . HOH U 5 .   ? 36.677  12.375  -43.950 1.00 41.75 ? 1662 HOH B O   1 ? 
HETATM 5393 O O   . HOH U 5 .   ? 13.083  19.029  -14.356 1.00 40.70 ? 1663 HOH B O   1 ? 
HETATM 5394 O O   . HOH U 5 .   ? 39.894  37.666  -14.272 1.00 37.78 ? 1664 HOH B O   1 ? 
HETATM 5395 O O   . HOH U 5 .   ? 35.250  22.998  -4.410  1.00 49.85 ? 1665 HOH B O   1 ? 
HETATM 5396 O O   . HOH U 5 .   ? 18.250  15.475  -13.723 1.00 40.43 ? 1666 HOH B O   1 ? 
HETATM 5397 O O   . HOH U 5 .   ? 21.706  -3.577  -26.608 1.00 47.85 ? 1667 HOH B O   1 ? 
HETATM 5398 O O   . HOH U 5 .   ? 17.445  26.185  -8.254  1.00 42.68 ? 1668 HOH B O   1 ? 
HETATM 5399 O O   . HOH U 5 .   ? 10.732  30.035  -34.662 1.00 36.99 ? 1669 HOH B O   1 ? 
HETATM 5400 O O   . HOH U 5 .   ? 27.118  22.135  -5.723  1.00 55.51 ? 1670 HOH B O   1 ? 
HETATM 5401 O O   . HOH U 5 .   ? 16.290  13.802  -47.591 1.00 50.62 ? 1671 HOH B O   1 ? 
HETATM 5402 O O   . HOH U 5 .   ? 39.051  5.093   -34.803 1.00 47.10 ? 1672 HOH B O   1 ? 
HETATM 5403 O O   . HOH U 5 .   ? 21.758  10.320  -49.145 1.00 50.27 ? 1673 HOH B O   1 ? 
HETATM 5404 O O   . HOH U 5 .   ? 33.849  1.741   -35.289 1.00 34.02 ? 1674 HOH B O   1 ? 
HETATM 5405 O O   . HOH U 5 .   ? 45.671  23.930  -16.528 1.00 45.32 ? 1675 HOH B O   1 ? 
HETATM 5406 O O   . HOH U 5 .   ? 10.951  30.634  -41.129 1.00 48.64 ? 1676 HOH B O   1 ? 
HETATM 5407 O O   . HOH U 5 .   ? 9.835   32.379  -30.715 1.00 42.59 ? 1677 HOH B O   1 ? 
HETATM 5408 O O   . HOH U 5 .   ? 24.797  2.627   -13.392 1.00 47.77 ? 1678 HOH B O   1 ? 
HETATM 5409 O O   . HOH U 5 .   ? 0.648   12.411  -30.102 1.00 40.69 ? 1679 HOH B O   1 ? 
HETATM 5410 O O   . HOH U 5 .   ? 20.041  16.729  -9.526  1.00 49.69 ? 1680 HOH B O   1 ? 
HETATM 5411 O O   . HOH U 5 .   ? 46.052  16.217  -24.474 1.00 45.76 ? 1681 HOH B O   1 ? 
HETATM 5412 O O   . HOH U 5 .   ? 35.312  7.669   -40.864 1.00 44.60 ? 1682 HOH B O   1 ? 
HETATM 5413 O O   . HOH U 5 .   ? 38.186  32.402  -5.123  1.00 36.22 ? 1683 HOH B O   1 ? 
HETATM 5414 O O   . HOH U 5 .   ? 48.798  19.835  -29.350 1.00 50.73 ? 1684 HOH B O   1 ? 
HETATM 5415 O O   . HOH U 5 .   ? 11.147  21.194  -13.187 1.00 45.94 ? 1685 HOH B O   1 ? 
HETATM 5416 O O   . HOH U 5 .   ? 44.608  21.426  -17.290 1.00 46.27 ? 1686 HOH B O   1 ? 
HETATM 5417 O O   . HOH U 5 .   ? 20.234  25.044  -3.035  1.00 51.30 ? 1687 HOH B O   1 ? 
HETATM 5418 O O   . HOH U 5 .   ? 35.974  2.966   -36.820 1.00 41.40 ? 1688 HOH B O   1 ? 
HETATM 5419 O O   . HOH U 5 .   ? 11.709  44.273  -29.546 1.00 44.99 ? 1689 HOH B O   1 ? 
HETATM 5420 O O   . HOH U 5 .   ? 15.774  16.208  -12.778 1.00 56.89 ? 1690 HOH B O   1 ? 
HETATM 5421 O O   . HOH U 5 .   ? 10.081  29.942  -38.397 1.00 46.93 ? 1691 HOH B O   1 ? 
HETATM 5422 O O   . HOH U 5 .   ? 3.157   23.028  -26.588 1.00 49.12 ? 1692 HOH B O   1 ? 
HETATM 5423 O O   . HOH U 5 .   ? 27.384  40.135  -32.874 1.00 46.38 ? 1693 HOH B O   1 ? 
HETATM 5424 O O   . HOH U 5 .   ? 38.381  2.313   -34.511 1.00 41.14 ? 1694 HOH B O   1 ? 
HETATM 5425 O O   . HOH U 5 .   ? 10.357  10.928  -38.042 1.00 33.20 ? 1695 HOH B O   1 ? 
HETATM 5426 O O   . HOH U 5 .   ? 28.989  41.256  -30.205 1.00 38.64 ? 1696 HOH B O   1 ? 
HETATM 5427 O O   . HOH U 5 .   ? 8.370   12.557  -35.409 1.00 37.86 ? 1697 HOH B O   1 ? 
HETATM 5428 O O   . HOH U 5 .   ? 42.593  26.640  -6.773  1.00 42.77 ? 1698 HOH B O   1 ? 
HETATM 5429 O O   . HOH U 5 .   ? 20.044  2.652   -39.051 1.00 42.50 ? 1699 HOH B O   1 ? 
HETATM 5430 O O   . HOH U 5 .   ? 6.169   25.722  -34.488 1.00 39.42 ? 1700 HOH B O   1 ? 
HETATM 5431 O O   . HOH U 5 .   ? 6.942   9.779   -24.621 1.00 37.85 ? 1701 HOH B O   1 ? 
HETATM 5432 O O   . HOH U 5 .   ? 13.276  22.706  -13.431 1.00 35.46 ? 1702 HOH B O   1 ? 
HETATM 5433 O O   . HOH U 5 .   ? 26.545  39.559  -35.245 1.00 46.97 ? 1703 HOH B O   1 ? 
HETATM 5434 O O   . HOH U 5 .   ? 8.387   28.193  -26.812 1.00 49.08 ? 1704 HOH B O   1 ? 
HETATM 5435 O O   . HOH U 5 .   ? -0.222  14.276  -36.311 1.00 49.77 ? 1705 HOH B O   1 ? 
HETATM 5436 O O   . HOH U 5 .   ? 7.511   27.449  -28.906 1.00 36.38 ? 1706 HOH B O   1 ? 
HETATM 5437 O O   . HOH U 5 .   ? 8.770   28.918  -33.912 1.00 32.79 ? 1707 HOH B O   1 ? 
HETATM 5438 O O   . HOH U 5 .   ? 9.911   7.547   -35.565 1.00 41.47 ? 1708 HOH B O   1 ? 
HETATM 5439 O O   . HOH U 5 .   ? 16.535  8.122   -12.589 1.00 40.97 ? 1709 HOH B O   1 ? 
HETATM 5440 O O   . HOH U 5 .   ? 31.148  16.432  -45.480 1.00 37.24 ? 1710 HOH B O   1 ? 
HETATM 5441 O O   . HOH U 5 .   ? 20.513  26.242  -52.786 1.00 45.96 ? 1711 HOH B O   1 ? 
HETATM 5442 O O   . HOH U 5 .   ? 4.051   14.312  -38.034 1.00 46.28 ? 1712 HOH B O   1 ? 
HETATM 5443 O O   . HOH U 5 .   ? 2.578   16.215  -23.784 1.00 38.06 ? 1713 HOH B O   1 ? 
HETATM 5444 O O   . HOH U 5 .   ? 14.268  45.914  -24.643 1.00 49.14 ? 1714 HOH B O   1 ? 
HETATM 5445 O O   . HOH U 5 .   ? 32.326  17.912  -43.699 1.00 40.96 ? 1715 HOH B O   1 ? 
HETATM 5446 O O   . HOH U 5 .   ? 1.967   19.935  -20.948 1.00 47.39 ? 1716 HOH B O   1 ? 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   2   ALA ALA A . n 
A 1 3   SER 3   3   3   SER SER A . n 
A 1 4   GLU 4   4   4   GLU GLU A . n 
A 1 5   ALA 5   5   5   ALA ALA A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   THR 7   7   7   THR THR A . n 
A 1 8   MET 8   8   8   MET MET A . n 
A 1 9   ILE 9   9   9   ILE ILE A . n 
A 1 10  VAL 10  10  10  VAL VAL A . n 
A 1 11  ASN 11  11  11  ASN ASN A . n 
A 1 12  LEU 12  12  12  LEU LEU A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  SER 15  15  15  SER SER A . n 
A 1 16  GLN 16  16  16  GLN GLN A . n 
A 1 17  ARG 17  17  17  ARG ARG A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  LEU 19  19  19  LEU LEU A . n 
A 1 20  GLN 20  20  20  GLN GLN A . n 
A 1 21  GLU 21  21  21  GLU GLU A . n 
A 1 22  PRO 22  22  22  PRO PRO A . n 
A 1 23  THR 23  23  23  THR THR A . n 
A 1 24  VAL 24  24  24  VAL VAL A . n 
A 1 25  GLU 25  25  25  GLU GLU A . n 
A 1 26  GLN 26  26  26  GLN GLN A . n 
A 1 27  MET 27  27  27  MET MET A . n 
A 1 28  ARG 28  28  28  ARG ARG A . n 
A 1 29  ALA 29  29  29  ALA ALA A . n 
A 1 30  GLY 30  30  30  GLY GLY A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  GLU 32  32  32  GLU GLU A . n 
A 1 33  ALA 33  33  33  ALA ALA A . n 
A 1 34  MET 34  34  34  MET MET A . n 
A 1 35  ALA 35  35  35  ALA ALA A . n 
A 1 36  GLN 36  36  36  GLN GLN A . n 
A 1 37  MET 37  37  37  MET MET A . n 
A 1 38  SER 38  38  38  SER SER A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  LEU 40  40  40  LEU LEU A . n 
A 1 41  PRO 41  41  41  PRO PRO A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  ASP 43  43  43  ASP ASP A . n 
A 1 44  VAL 44  44  44  VAL VAL A . n 
A 1 45  GLU 45  45  45  GLU GLU A . n 
A 1 46  LEU 46  46  46  LEU LEU A . n 
A 1 47  THR 47  47  47  THR THR A . n 
A 1 48  THR 48  48  48  THR THR A . n 
A 1 49  VAL 49  49  49  VAL VAL A . n 
A 1 50  ASP 50  50  50  ASP ASP A . n 
A 1 51  ALA 51  51  51  ALA ALA A . n 
A 1 52  GLY 52  52  52  GLY GLY A . n 
A 1 53  GLY 53  53  53  GLY GLY A . n 
A 1 54  VAL 54  54  54  VAL VAL A . n 
A 1 55  PRO 55  55  55  PRO PRO A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  TRP 58  58  58  TRP TRP A . n 
A 1 59  VAL 59  59  59  VAL VAL A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  VAL 61  61  61  VAL VAL A . n 
A 1 62  PRO 62  62  62  PRO PRO A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  SER 64  64  64  SER SER A . n 
A 1 65  ASP 65  65  65  ASP ASP A . n 
A 1 66  PRO 66  66  66  PRO PRO A . n 
A 1 67  ASP 67  67  67  ASP ASP A . n 
A 1 68  ARG 68  68  68  ARG ARG A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  VAL 70  70  70  VAL VAL A . n 
A 1 71  LEU 71  71  71  LEU LEU A . n 
A 1 72  TYR 72  72  72  TYR TYR A . n 
A 1 73  LEU 73  73  73  LEU LEU A . n 
A 1 74  HIS 74  74  74  HIS HIS A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  GLY 77  77  77  GLY GLY A . n 
A 1 78  TYR 78  78  78  TYR TYR A . n 
A 1 79  VAL 79  79  79  VAL VAL A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  GLY 81  81  81  GLY GLY A . n 
A 1 82  SER 82  82  82  SER SER A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  ARG 84  84  84  ARG ARG A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  HIS 86  86  86  HIS HIS A . n 
A 1 87  ARG 87  87  87  ARG ARG A . n 
A 1 88  ASP 88  88  88  ASP ASP A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  GLN 91  91  91  GLN GLN A . n 
A 1 92  ARG 92  92  92  ARG ARG A . n 
A 1 93  ILE 93  93  93  ILE ILE A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ARG 95  95  95  ARG ARG A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  ALA 97  97  97  ALA ALA A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  CYS 99  99  99  CYS CYS A . n 
A 1 100 ARG 100 100 100 ARG ARG A . n 
A 1 101 VAL 101 101 101 VAL VAL A . n 
A 1 102 LEU 102 102 102 LEU LEU A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 ILE 104 104 104 ILE ILE A . n 
A 1 105 ASP 105 105 105 ASP ASP A . n 
A 1 106 TYR 106 106 106 TYR TYR A . n 
A 1 107 ARG 107 107 107 ARG ARG A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 PRO 110 110 110 PRO PRO A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 HIS 112 112 112 HIS HIS A . n 
A 1 113 PRO 113 113 113 PRO PRO A . n 
A 1 114 HIS 114 114 114 HIS HIS A . n 
A 1 115 PRO 115 115 115 PRO PRO A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 ALA 117 117 117 ALA ALA A . n 
A 1 118 VAL 118 118 118 VAL VAL A . n 
A 1 119 GLU 119 119 119 GLU GLU A . n 
A 1 120 ASP 120 120 120 ASP ASP A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 THR 122 122 122 THR THR A . n 
A 1 123 ARG 123 123 123 ARG ARG A . n 
A 1 124 ALA 124 124 124 ALA ALA A . n 
A 1 125 TYR 125 125 125 TYR TYR A . n 
A 1 126 ARG 126 126 126 ARG ARG A . n 
A 1 127 TRP 127 127 127 TRP TRP A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 GLU 130 130 130 GLU GLU A . n 
A 1 131 THR 131 131 131 THR THR A . n 
A 1 132 GLY 132 132 132 GLY GLY A . n 
A 1 133 SER 133 133 133 SER SER A . n 
A 1 134 ASP 134 134 134 ASP ASP A . n 
A 1 135 PRO 135 135 135 PRO PRO A . n 
A 1 136 LYS 136 136 136 LYS LYS A . n 
A 1 137 ARG 137 137 137 ARG ARG A . n 
A 1 138 MET 138 138 138 MET MET A . n 
A 1 139 ALA 139 139 139 ALA ALA A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 ALA 141 141 141 ALA ALA A . n 
A 1 142 GLY 142 142 142 GLY GLY A . n 
A 1 143 ASP 143 143 143 ASP ASP A . n 
A 1 144 ALA 144 144 144 ALA ALA A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 GLY 147 147 147 GLY GLY A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 THR 150 150 150 THR THR A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 ALA 152 152 152 ALA ALA A . n 
A 1 153 THR 153 153 153 THR THR A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 VAL 155 155 155 VAL VAL A . n 
A 1 156 ALA 156 156 156 ALA ALA A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 ARG 158 158 158 ARG ARG A . n 
A 1 159 ASP 159 159 159 ASP ASP A . n 
A 1 160 ALA 160 160 160 ALA ALA A . n 
A 1 161 GLY 161 161 161 GLY GLY A . n 
A 1 162 VAL 162 162 162 VAL VAL A . n 
A 1 163 PRO 163 163 163 PRO PRO A . n 
A 1 164 LEU 164 164 164 LEU LEU A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 ALA 167 167 167 ALA ALA A . n 
A 1 168 ALA 168 168 168 ALA ALA A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 CYS 170 170 170 CYS CYS A . n 
A 1 171 LEU 171 171 171 LEU LEU A . n 
A 1 172 SER 172 172 172 SER SER A . n 
A 1 173 PRO 173 173 173 PRO PRO A . n 
A 1 174 TRP 174 174 174 TRP TRP A . n 
A 1 175 VAL 175 175 175 VAL VAL A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ILE 180 180 180 ILE ILE A . n 
A 1 181 GLY 181 181 181 GLY GLY A . n 
A 1 182 GLU 182 182 182 GLU GLU A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 MET 184 184 184 MET MET A . n 
A 1 185 THR 185 185 185 THR THR A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 LYS 187 187 187 LYS LYS A . n 
A 1 188 ALA 188 188 188 ALA ALA A . n 
A 1 189 ALA 189 189 189 ALA ALA A . n 
A 1 190 VAL 190 190 190 VAL VAL A . n 
A 1 191 ASP 191 191 191 ASP ASP A . n 
A 1 192 PRO 192 192 192 PRO PRO A . n 
A 1 193 MET 193 193 193 MET MET A . n 
A 1 194 VAL 194 194 194 VAL VAL A . n 
A 1 195 GLN 195 195 195 GLN GLN A . n 
A 1 196 ARG 196 196 196 ARG ARG A . n 
A 1 197 GLU 197 197 197 GLU GLU A . n 
A 1 198 PRO 198 198 198 PRO PRO A . n 
A 1 199 LEU 199 199 199 LEU LEU A . n 
A 1 200 LEU 200 200 200 LEU LEU A . n 
A 1 201 ARG 201 201 201 ARG ARG A . n 
A 1 202 MET 202 202 202 MET MET A . n 
A 1 203 ALA 203 203 203 ALA ALA A . n 
A 1 204 SER 204 204 204 SER SER A . n 
A 1 205 MET 205 205 205 MET MET A . n 
A 1 206 TYR 206 206 206 TYR TYR A . n 
A 1 207 LEU 207 207 207 LEU LEU A . n 
A 1 208 ALA 208 208 208 ALA ALA A . n 
A 1 209 GLY 209 209 209 GLY GLY A . n 
A 1 210 GLN 210 210 210 GLN GLN A . n 
A 1 211 ASP 211 211 211 ASP ASP A . n 
A 1 212 PRO 212 212 212 PRO PRO A . n 
A 1 213 ARG 213 213 213 ARG ARG A . n 
A 1 214 THR 214 214 214 THR THR A . n 
A 1 215 PRO 215 215 215 PRO PRO A . n 
A 1 216 LEU 216 216 216 LEU LEU A . n 
A 1 217 ALA 217 217 217 ALA ALA A . n 
A 1 218 ALA 218 218 218 ALA ALA A . n 
A 1 219 PRO 219 219 219 PRO PRO A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 TYR 221 221 221 TYR TYR A . n 
A 1 222 ALA 222 222 222 ALA ALA A . n 
A 1 223 ASP 223 223 223 ASP ASP A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 ARG 225 225 225 ARG ARG A . n 
A 1 226 GLY 226 226 226 GLY GLY A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 PRO 228 228 228 PRO PRO A . n 
A 1 229 PRO 229 229 229 PRO PRO A . n 
A 1 230 LEU 230 230 230 LEU LEU A . n 
A 1 231 LEU 231 231 231 LEU LEU A . n 
A 1 232 ILE 232 232 232 ILE ILE A . n 
A 1 233 GLN 233 233 233 GLN GLN A . n 
A 1 234 VAL 234 234 234 VAL VAL A . n 
A 1 235 GLY 235 235 235 GLY GLY A . n 
A 1 236 THR 236 236 236 THR THR A . n 
A 1 237 ALA 237 237 237 ALA ALA A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 THR 239 239 239 THR THR A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 ASP 242 242 242 ASP ASP A . n 
A 1 243 ASP 243 243 243 ASP ASP A . n 
A 1 244 SER 244 244 244 SER SER A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 ARG 246 246 246 ARG ARG A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 ALA 248 248 248 ALA ALA A . n 
A 1 249 GLU 249 249 249 GLU GLU A . n 
A 1 250 ARG 250 250 250 ARG ARG A . n 
A 1 251 ALA 251 251 251 ALA ALA A . n 
A 1 252 ARG 252 252 252 ARG ARG A . n 
A 1 253 ALA 253 253 253 ALA ALA A . n 
A 1 254 ALA 254 254 254 ALA ALA A . n 
A 1 255 GLY 255 255 255 GLY GLY A . n 
A 1 256 VAL 256 256 256 VAL VAL A . n 
A 1 257 GLN 257 257 257 GLN GLN A . n 
A 1 258 VAL 258 258 258 VAL VAL A . n 
A 1 259 THR 259 259 259 THR THR A . n 
A 1 260 LEU 260 260 260 LEU LEU A . n 
A 1 261 GLU 261 261 261 GLU GLU A . n 
A 1 262 PRO 262 262 262 PRO PRO A . n 
A 1 263 TRP 263 263 263 TRP TRP A . n 
A 1 264 GLU 264 264 264 GLU GLU A . n 
A 1 265 ASP 265 265 265 ASP ASP A . n 
A 1 266 MET 266 266 266 MET MET A . n 
A 1 267 ILE 267 267 267 ILE ILE A . n 
A 1 268 HIS 268 268 268 HIS HIS A . n 
A 1 269 VAL 269 269 269 VAL VAL A . n 
A 1 270 TRP 270 270 270 TRP TRP A . n 
A 1 271 GLN 271 271 271 GLN GLN A . n 
A 1 272 ALA 272 272 272 ALA ALA A . n 
A 1 273 PHE 273 273 273 PHE PHE A . n 
A 1 274 ALA 274 274 274 ALA ALA A . n 
A 1 275 ALA 275 275 275 ALA ALA A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 PRO 278 278 278 PRO PRO A . n 
A 1 279 GLU 279 279 279 GLU GLU A . n 
A 1 280 GLY 280 280 280 GLY GLY A . n 
A 1 281 GLN 281 281 281 GLN GLN A . n 
A 1 282 GLN 282 282 282 GLN GLN A . n 
A 1 283 ALA 283 283 283 ALA ALA A . n 
A 1 284 ILE 284 284 284 ILE ILE A . n 
A 1 285 GLU 285 285 285 GLU GLU A . n 
A 1 286 ARG 286 286 286 ARG ARG A . n 
A 1 287 ILE 287 287 287 ILE ILE A . n 
A 1 288 GLY 288 288 288 GLY GLY A . n 
A 1 289 GLU 289 289 289 GLU GLU A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 ARG 292 292 292 ARG ARG A . n 
A 1 293 GLN 293 293 293 GLN GLN A . n 
A 1 294 HIS 294 294 294 HIS HIS A . n 
A 1 295 TRP 295 295 295 TRP TRP A . n 
A 1 296 GLN 296 296 296 GLN GLN A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ALA 2   2   2   ALA ALA B . n 
B 1 3   SER 3   3   3   SER SER B . n 
B 1 4   GLU 4   4   4   GLU GLU B . n 
B 1 5   ALA 5   5   5   ALA ALA B . n 
B 1 6   LEU 6   6   6   LEU LEU B . n 
B 1 7   THR 7   7   7   THR THR B . n 
B 1 8   MET 8   8   8   MET MET B . n 
B 1 9   ILE 9   9   9   ILE ILE B . n 
B 1 10  VAL 10  10  10  VAL VAL B . n 
B 1 11  ASN 11  11  11  ASN ASN B . n 
B 1 12  LEU 12  12  12  LEU LEU B . n 
B 1 13  LEU 13  13  13  LEU LEU B . n 
B 1 14  ARG 14  14  14  ARG ARG B . n 
B 1 15  SER 15  15  15  SER SER B . n 
B 1 16  GLN 16  16  16  GLN GLN B . n 
B 1 17  ARG 17  17  17  ARG ARG B . n 
B 1 18  PRO 18  18  18  PRO PRO B . n 
B 1 19  LEU 19  19  19  LEU LEU B . n 
B 1 20  GLN 20  20  20  GLN GLN B . n 
B 1 21  GLU 21  21  21  GLU GLU B . n 
B 1 22  PRO 22  22  22  PRO PRO B . n 
B 1 23  THR 23  23  23  THR THR B . n 
B 1 24  VAL 24  24  24  VAL VAL B . n 
B 1 25  GLU 25  25  25  GLU GLU B . n 
B 1 26  GLN 26  26  26  GLN GLN B . n 
B 1 27  MET 27  27  27  MET MET B . n 
B 1 28  ARG 28  28  28  ARG ARG B . n 
B 1 29  ALA 29  29  29  ALA ALA B . n 
B 1 30  GLY 30  30  30  GLY GLY B . n 
B 1 31  LEU 31  31  31  LEU LEU B . n 
B 1 32  GLU 32  32  32  GLU GLU B . n 
B 1 33  ALA 33  33  33  ALA ALA B . n 
B 1 34  MET 34  34  34  MET MET B . n 
B 1 35  ALA 35  35  35  ALA ALA B . n 
B 1 36  GLN 36  36  36  GLN GLN B . n 
B 1 37  MET 37  37  37  MET MET B . n 
B 1 38  SER 38  38  38  SER SER B . n 
B 1 39  PRO 39  39  39  PRO PRO B . n 
B 1 40  LEU 40  40  40  LEU LEU B . n 
B 1 41  PRO 41  41  41  PRO PRO B . n 
B 1 42  ALA 42  42  42  ALA ALA B . n 
B 1 43  ASP 43  43  43  ASP ASP B . n 
B 1 44  VAL 44  44  44  VAL VAL B . n 
B 1 45  GLU 45  45  45  GLU GLU B . n 
B 1 46  LEU 46  46  46  LEU LEU B . n 
B 1 47  THR 47  47  47  THR THR B . n 
B 1 48  THR 48  48  48  THR THR B . n 
B 1 49  VAL 49  49  49  VAL VAL B . n 
B 1 50  ASP 50  50  50  ASP ASP B . n 
B 1 51  ALA 51  51  51  ALA ALA B . n 
B 1 52  GLY 52  52  52  GLY GLY B . n 
B 1 53  GLY 53  53  53  GLY GLY B . n 
B 1 54  VAL 54  54  54  VAL VAL B . n 
B 1 55  PRO 55  55  55  PRO PRO B . n 
B 1 56  GLY 56  56  56  GLY GLY B . n 
B 1 57  ALA 57  57  57  ALA ALA B . n 
B 1 58  TRP 58  58  58  TRP TRP B . n 
B 1 59  VAL 59  59  59  VAL VAL B . n 
B 1 60  ARG 60  60  60  ARG ARG B . n 
B 1 61  VAL 61  61  61  VAL VAL B . n 
B 1 62  PRO 62  62  62  PRO PRO B . n 
B 1 63  GLU 63  63  63  GLU GLU B . n 
B 1 64  SER 64  64  64  SER SER B . n 
B 1 65  ASP 65  65  65  ASP ASP B . n 
B 1 66  PRO 66  66  66  PRO PRO B . n 
B 1 67  ASP 67  67  67  ASP ASP B . n 
B 1 68  ARG 68  68  68  ARG ARG B . n 
B 1 69  VAL 69  69  69  VAL VAL B . n 
B 1 70  VAL 70  70  70  VAL VAL B . n 
B 1 71  LEU 71  71  71  LEU LEU B . n 
B 1 72  TYR 72  72  72  TYR TYR B . n 
B 1 73  LEU 73  73  73  LEU LEU B . n 
B 1 74  HIS 74  74  74  HIS HIS B . n 
B 1 75  GLY 75  75  75  GLY GLY B . n 
B 1 76  GLY 76  76  76  GLY GLY B . n 
B 1 77  GLY 77  77  77  GLY GLY B . n 
B 1 78  TYR 78  78  78  TYR TYR B . n 
B 1 79  VAL 79  79  79  VAL VAL B . n 
B 1 80  ILE 80  80  80  ILE ILE B . n 
B 1 81  GLY 81  81  81  GLY GLY B . n 
B 1 82  SER 82  82  82  SER SER B . n 
B 1 83  ILE 83  83  83  ILE ILE B . n 
B 1 84  ARG 84  84  84  ARG ARG B . n 
B 1 85  THR 85  85  85  THR THR B . n 
B 1 86  HIS 86  86  86  HIS HIS B . n 
B 1 87  ARG 87  87  87  ARG ARG B . n 
B 1 88  ASP 88  88  88  ASP ASP B . n 
B 1 89  LEU 89  89  89  LEU LEU B . n 
B 1 90  ALA 90  90  90  ALA ALA B . n 
B 1 91  GLN 91  91  91  GLN GLN B . n 
B 1 92  ARG 92  92  92  ARG ARG B . n 
B 1 93  ILE 93  93  93  ILE ILE B . n 
B 1 94  ALA 94  94  94  ALA ALA B . n 
B 1 95  ARG 95  95  95  ARG ARG B . n 
B 1 96  ALA 96  96  96  ALA ALA B . n 
B 1 97  ALA 97  97  97  ALA ALA B . n 
B 1 98  ARG 98  98  98  ARG ARG B . n 
B 1 99  CYS 99  99  99  CYS CYS B . n 
B 1 100 ARG 100 100 100 ARG ARG B . n 
B 1 101 VAL 101 101 101 VAL VAL B . n 
B 1 102 LEU 102 102 102 LEU LEU B . n 
B 1 103 LEU 103 103 103 LEU LEU B . n 
B 1 104 ILE 104 104 104 ILE ILE B . n 
B 1 105 ASP 105 105 105 ASP ASP B . n 
B 1 106 TYR 106 106 106 TYR TYR B . n 
B 1 107 ARG 107 107 107 ARG ARG B . n 
B 1 108 LEU 108 108 108 LEU LEU B . n 
B 1 109 ALA 109 109 109 ALA ALA B . n 
B 1 110 PRO 110 110 110 PRO PRO B . n 
B 1 111 GLU 111 111 111 GLU GLU B . n 
B 1 112 HIS 112 112 112 HIS HIS B . n 
B 1 113 PRO 113 113 113 PRO PRO B . n 
B 1 114 HIS 114 114 114 HIS HIS B . n 
B 1 115 PRO 115 115 115 PRO PRO B . n 
B 1 116 ALA 116 116 116 ALA ALA B . n 
B 1 117 ALA 117 117 117 ALA ALA B . n 
B 1 118 VAL 118 118 118 VAL VAL B . n 
B 1 119 GLU 119 119 119 GLU GLU B . n 
B 1 120 ASP 120 120 120 ASP ASP B . n 
B 1 121 SER 121 121 121 SER SER B . n 
B 1 122 THR 122 122 122 THR THR B . n 
B 1 123 ARG 123 123 123 ARG ARG B . n 
B 1 124 ALA 124 124 124 ALA ALA B . n 
B 1 125 TYR 125 125 125 TYR TYR B . n 
B 1 126 ARG 126 126 126 ARG ARG B . n 
B 1 127 TRP 127 127 127 TRP TRP B . n 
B 1 128 LEU 128 128 128 LEU LEU B . n 
B 1 129 LEU 129 129 129 LEU LEU B . n 
B 1 130 GLU 130 130 130 GLU GLU B . n 
B 1 131 THR 131 131 131 THR THR B . n 
B 1 132 GLY 132 132 132 GLY GLY B . n 
B 1 133 SER 133 133 133 SER SER B . n 
B 1 134 ASP 134 134 134 ASP ASP B . n 
B 1 135 PRO 135 135 135 PRO PRO B . n 
B 1 136 LYS 136 136 136 LYS LYS B . n 
B 1 137 ARG 137 137 137 ARG ARG B . n 
B 1 138 MET 138 138 138 MET MET B . n 
B 1 139 ALA 139 139 139 ALA ALA B . n 
B 1 140 ILE 140 140 140 ILE ILE B . n 
B 1 141 ALA 141 141 141 ALA ALA B . n 
B 1 142 GLY 142 142 142 GLY GLY B . n 
B 1 143 ASP 143 143 143 ASP ASP B . n 
B 1 144 ALA 144 144 144 ALA ALA B . n 
B 1 145 ALA 145 145 145 ALA ALA B . n 
B 1 146 GLY 146 146 146 GLY GLY B . n 
B 1 147 GLY 147 147 147 GLY GLY B . n 
B 1 148 GLY 148 148 148 GLY GLY B . n 
B 1 149 LEU 149 149 149 LEU LEU B . n 
B 1 150 THR 150 150 150 THR THR B . n 
B 1 151 VAL 151 151 151 VAL VAL B . n 
B 1 152 ALA 152 152 152 ALA ALA B . n 
B 1 153 THR 153 153 153 THR THR B . n 
B 1 154 LEU 154 154 154 LEU LEU B . n 
B 1 155 VAL 155 155 155 VAL VAL B . n 
B 1 156 ALA 156 156 156 ALA ALA B . n 
B 1 157 LEU 157 157 157 LEU LEU B . n 
B 1 158 ARG 158 158 158 ARG ARG B . n 
B 1 159 ASP 159 159 159 ASP ASP B . n 
B 1 160 ALA 160 160 160 ALA ALA B . n 
B 1 161 GLY 161 161 161 GLY GLY B . n 
B 1 162 VAL 162 162 162 VAL VAL B . n 
B 1 163 PRO 163 163 163 PRO PRO B . n 
B 1 164 LEU 164 164 164 LEU LEU B . n 
B 1 165 PRO 165 165 165 PRO PRO B . n 
B 1 166 ALA 166 166 166 ALA ALA B . n 
B 1 167 ALA 167 167 167 ALA ALA B . n 
B 1 168 ALA 168 168 168 ALA ALA B . n 
B 1 169 VAL 169 169 169 VAL VAL B . n 
B 1 170 CYS 170 170 170 CYS CYS B . n 
B 1 171 LEU 171 171 171 LEU LEU B . n 
B 1 172 SER 172 172 172 SER SER B . n 
B 1 173 PRO 173 173 173 PRO PRO B . n 
B 1 174 TRP 174 174 174 TRP TRP B . n 
B 1 175 VAL 175 175 175 VAL VAL B . n 
B 1 176 ASP 176 176 176 ASP ASP B . n 
B 1 177 LEU 177 177 177 LEU LEU B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 GLY 179 179 179 GLY GLY B . n 
B 1 180 ILE 180 180 180 ILE ILE B . n 
B 1 181 GLY 181 181 181 GLY GLY B . n 
B 1 182 GLU 182 182 182 GLU GLU B . n 
B 1 183 SER 183 183 183 SER SER B . n 
B 1 184 MET 184 184 184 MET MET B . n 
B 1 185 THR 185 185 185 THR THR B . n 
B 1 186 THR 186 186 186 THR THR B . n 
B 1 187 LYS 187 187 187 LYS LYS B . n 
B 1 188 ALA 188 188 188 ALA ALA B . n 
B 1 189 ALA 189 189 189 ALA ALA B . n 
B 1 190 VAL 190 190 190 VAL VAL B . n 
B 1 191 ASP 191 191 191 ASP ASP B . n 
B 1 192 PRO 192 192 192 PRO PRO B . n 
B 1 193 MET 193 193 193 MET MET B . n 
B 1 194 VAL 194 194 194 VAL VAL B . n 
B 1 195 GLN 195 195 195 GLN GLN B . n 
B 1 196 ARG 196 196 196 ARG ARG B . n 
B 1 197 GLU 197 197 197 GLU GLU B . n 
B 1 198 PRO 198 198 198 PRO PRO B . n 
B 1 199 LEU 199 199 199 LEU LEU B . n 
B 1 200 LEU 200 200 200 LEU LEU B . n 
B 1 201 ARG 201 201 201 ARG ARG B . n 
B 1 202 MET 202 202 202 MET MET B . n 
B 1 203 ALA 203 203 203 ALA ALA B . n 
B 1 204 SER 204 204 204 SER SER B . n 
B 1 205 MET 205 205 205 MET MET B . n 
B 1 206 TYR 206 206 206 TYR TYR B . n 
B 1 207 LEU 207 207 207 LEU LEU B . n 
B 1 208 ALA 208 208 208 ALA ALA B . n 
B 1 209 GLY 209 209 209 GLY GLY B . n 
B 1 210 GLN 210 210 210 GLN GLN B . n 
B 1 211 ASP 211 211 211 ASP ASP B . n 
B 1 212 PRO 212 212 212 PRO PRO B . n 
B 1 213 ARG 213 213 213 ARG ARG B . n 
B 1 214 THR 214 214 214 THR THR B . n 
B 1 215 PRO 215 215 215 PRO PRO B . n 
B 1 216 LEU 216 216 216 LEU LEU B . n 
B 1 217 ALA 217 217 217 ALA ALA B . n 
B 1 218 ALA 218 218 218 ALA ALA B . n 
B 1 219 PRO 219 219 219 PRO PRO B . n 
B 1 220 LEU 220 220 220 LEU LEU B . n 
B 1 221 TYR 221 221 221 TYR TYR B . n 
B 1 222 ALA 222 222 222 ALA ALA B . n 
B 1 223 ASP 223 223 223 ASP ASP B . n 
B 1 224 LEU 224 224 224 LEU LEU B . n 
B 1 225 ARG 225 225 225 ARG ARG B . n 
B 1 226 GLY 226 226 226 GLY GLY B . n 
B 1 227 LEU 227 227 227 LEU LEU B . n 
B 1 228 PRO 228 228 228 PRO PRO B . n 
B 1 229 PRO 229 229 229 PRO PRO B . n 
B 1 230 LEU 230 230 230 LEU LEU B . n 
B 1 231 LEU 231 231 231 LEU LEU B . n 
B 1 232 ILE 232 232 232 ILE ILE B . n 
B 1 233 GLN 233 233 233 GLN GLN B . n 
B 1 234 VAL 234 234 234 VAL VAL B . n 
B 1 235 GLY 235 235 235 GLY GLY B . n 
B 1 236 THR 236 236 236 THR THR B . n 
B 1 237 ALA 237 237 237 ALA ALA B . n 
B 1 238 GLU 238 238 238 GLU GLU B . n 
B 1 239 THR 239 239 239 THR THR B . n 
B 1 240 LEU 240 240 240 LEU LEU B . n 
B 1 241 LEU 241 241 241 LEU LEU B . n 
B 1 242 ASP 242 242 242 ASP ASP B . n 
B 1 243 ASP 243 243 243 ASP ASP B . n 
B 1 244 SER 244 244 244 SER SER B . n 
B 1 245 VAL 245 245 245 VAL VAL B . n 
B 1 246 ARG 246 246 246 ARG ARG B . n 
B 1 247 LEU 247 247 247 LEU LEU B . n 
B 1 248 ALA 248 248 248 ALA ALA B . n 
B 1 249 GLU 249 249 249 GLU GLU B . n 
B 1 250 ARG 250 250 250 ARG ARG B . n 
B 1 251 ALA 251 251 251 ALA ALA B . n 
B 1 252 ARG 252 252 252 ARG ARG B . n 
B 1 253 ALA 253 253 253 ALA ALA B . n 
B 1 254 ALA 254 254 254 ALA ALA B . n 
B 1 255 GLY 255 255 255 GLY GLY B . n 
B 1 256 VAL 256 256 256 VAL VAL B . n 
B 1 257 GLN 257 257 257 GLN GLN B . n 
B 1 258 VAL 258 258 258 VAL VAL B . n 
B 1 259 THR 259 259 259 THR THR B . n 
B 1 260 LEU 260 260 260 LEU LEU B . n 
B 1 261 GLU 261 261 261 GLU GLU B . n 
B 1 262 PRO 262 262 262 PRO PRO B . n 
B 1 263 TRP 263 263 263 TRP TRP B . n 
B 1 264 GLU 264 264 264 GLU GLU B . n 
B 1 265 ASP 265 265 265 ASP ASP B . n 
B 1 266 MET 266 266 266 MET MET B . n 
B 1 267 ILE 267 267 267 ILE ILE B . n 
B 1 268 HIS 268 268 268 HIS HIS B . n 
B 1 269 VAL 269 269 269 VAL VAL B . n 
B 1 270 TRP 270 270 270 TRP TRP B . n 
B 1 271 GLN 271 271 271 GLN GLN B . n 
B 1 272 ALA 272 272 272 ALA ALA B . n 
B 1 273 PHE 273 273 273 PHE PHE B . n 
B 1 274 ALA 274 274 274 ALA ALA B . n 
B 1 275 ALA 275 275 275 ALA ALA B . n 
B 1 276 MET 276 276 276 MET MET B . n 
B 1 277 LEU 277 277 277 LEU LEU B . n 
B 1 278 PRO 278 278 278 PRO PRO B . n 
B 1 279 GLU 279 279 279 GLU GLU B . n 
B 1 280 GLY 280 280 280 GLY GLY B . n 
B 1 281 GLN 281 281 281 GLN GLN B . n 
B 1 282 GLN 282 282 282 GLN GLN B . n 
B 1 283 ALA 283 283 283 ALA ALA B . n 
B 1 284 ILE 284 284 284 ILE ILE B . n 
B 1 285 GLU 285 285 285 GLU GLU B . n 
B 1 286 ARG 286 286 286 ARG ARG B . n 
B 1 287 ILE 287 287 287 ILE ILE B . n 
B 1 288 GLY 288 288 288 GLY GLY B . n 
B 1 289 GLU 289 289 289 GLU GLU B . n 
B 1 290 PHE 290 290 290 PHE PHE B . n 
B 1 291 LEU 291 291 291 LEU LEU B . n 
B 1 292 ARG 292 292 292 ARG ARG B . n 
B 1 293 GLN 293 293 293 GLN GLN B . n 
B 1 294 HIS 294 294 294 HIS HIS B . n 
B 1 295 TRP 295 295 295 TRP TRP B . n 
B 1 296 GLN 296 296 296 GLN GLN B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 FMT 1   1301 1301 FMT FMT A . 
D 2 FMT 1   1302 1401 FMT FMT A . 
E 2 FMT 1   1303 1501 FMT FMT A . 
F 2 FMT 1   1304 1601 FMT FMT A . 
G 2 FMT 1   1305 1801 FMT FMT A . 
H 2 FMT 1   1306 1901 FMT FMT A . 
I 3 ACT 1   1307 2101 ACT ACT A . 
J 2 FMT 1   1308 2201 FMT FMT A . 
K 2 FMT 1   1309 2301 FMT FMT A . 
L 2 FMT 1   1310 2401 FMT FMT A . 
M 2 FMT 1   1311 2501 FMT FMT A . 
N 2 FMT 1   1312 1501 FMT FMT A . 
O 2 FMT 1   1313 601  FMT FMT A . 
P 2 FMT 1   1314 801  FMT FMT A . 
Q 4 RXH 1   1301 1301 RXH NPM B . 
R 2 FMT 1   1302 1601 FMT FMT B . 
S 3 ACT 1   1303 1901 ACT ACT B . 
T 5 HOH 1   1401 271  HOH HOH A . 
T 5 HOH 2   1402 263  HOH HOH A . 
T 5 HOH 3   1403 191  HOH HOH A . 
T 5 HOH 4   1404 279  HOH HOH A . 
T 5 HOH 5   1405 276  HOH HOH A . 
T 5 HOH 6   1406 5    HOH HOH A . 
T 5 HOH 7   1407 227  HOH HOH A . 
T 5 HOH 8   1408 281  HOH HOH A . 
T 5 HOH 9   1409 190  HOH HOH A . 
T 5 HOH 10  1410 178  HOH HOH A . 
T 5 HOH 11  1411 283  HOH HOH A . 
T 5 HOH 12  1412 196  HOH HOH A . 
T 5 HOH 13  1413 172  HOH HOH A . 
T 5 HOH 14  1414 59   HOH HOH A . 
T 5 HOH 15  1415 105  HOH HOH A . 
T 5 HOH 16  1416 72   HOH HOH A . 
T 5 HOH 17  1417 152  HOH HOH A . 
T 5 HOH 18  1418 248  HOH HOH A . 
T 5 HOH 19  1419 198  HOH HOH A . 
T 5 HOH 20  1420 24   HOH HOH A . 
T 5 HOH 21  1421 106  HOH HOH A . 
T 5 HOH 22  1422 378  HOH HOH A . 
T 5 HOH 23  1423 362  HOH HOH A . 
T 5 HOH 24  1424 330  HOH HOH A . 
T 5 HOH 25  1425 158  HOH HOH A . 
T 5 HOH 26  1426 332  HOH HOH A . 
T 5 HOH 27  1427 257  HOH HOH A . 
T 5 HOH 28  1428 66   HOH HOH A . 
T 5 HOH 29  1429 126  HOH HOH A . 
T 5 HOH 30  1430 64   HOH HOH A . 
T 5 HOH 31  1431 297  HOH HOH A . 
T 5 HOH 32  1432 239  HOH HOH A . 
T 5 HOH 33  1433 28   HOH HOH A . 
T 5 HOH 34  1434 200  HOH HOH A . 
T 5 HOH 35  1435 465  HOH HOH A . 
T 5 HOH 36  1436 345  HOH HOH A . 
T 5 HOH 37  1437 223  HOH HOH A . 
T 5 HOH 38  1438 339  HOH HOH A . 
T 5 HOH 39  1439 73   HOH HOH A . 
T 5 HOH 40  1440 301  HOH HOH A . 
T 5 HOH 41  1441 254  HOH HOH A . 
T 5 HOH 42  1442 118  HOH HOH A . 
T 5 HOH 43  1443 9    HOH HOH A . 
T 5 HOH 44  1444 424  HOH HOH A . 
T 5 HOH 45  1445 167  HOH HOH A . 
T 5 HOH 46  1446 413  HOH HOH A . 
T 5 HOH 47  1447 120  HOH HOH A . 
T 5 HOH 48  1448 207  HOH HOH A . 
T 5 HOH 49  1449 10   HOH HOH A . 
T 5 HOH 50  1450 335  HOH HOH A . 
T 5 HOH 51  1451 333  HOH HOH A . 
T 5 HOH 52  1452 140  HOH HOH A . 
T 5 HOH 53  1453 326  HOH HOH A . 
T 5 HOH 54  1454 275  HOH HOH A . 
T 5 HOH 55  1455 235  HOH HOH A . 
T 5 HOH 56  1456 157  HOH HOH A . 
T 5 HOH 57  1457 3    HOH HOH A . 
T 5 HOH 58  1458 397  HOH HOH A . 
T 5 HOH 59  1459 81   HOH HOH A . 
T 5 HOH 60  1460 110  HOH HOH A . 
T 5 HOH 61  1461 116  HOH HOH A . 
T 5 HOH 62  1462 45   HOH HOH A . 
T 5 HOH 63  1463 427  HOH HOH A . 
T 5 HOH 64  1464 197  HOH HOH A . 
T 5 HOH 65  1465 211  HOH HOH A . 
T 5 HOH 66  1466 215  HOH HOH A . 
T 5 HOH 67  1467 12   HOH HOH A . 
T 5 HOH 68  1468 163  HOH HOH A . 
T 5 HOH 69  1469 151  HOH HOH A . 
T 5 HOH 70  1470 19   HOH HOH A . 
T 5 HOH 71  1471 2    HOH HOH A . 
T 5 HOH 72  1472 249  HOH HOH A . 
T 5 HOH 73  1473 343  HOH HOH A . 
T 5 HOH 74  1474 270  HOH HOH A . 
T 5 HOH 75  1475 238  HOH HOH A . 
T 5 HOH 76  1476 188  HOH HOH A . 
T 5 HOH 77  1477 270  HOH HOH A . 
T 5 HOH 78  1478 147  HOH HOH A . 
T 5 HOH 79  1479 122  HOH HOH A . 
T 5 HOH 80  1480 79   HOH HOH A . 
T 5 HOH 81  1481 497  HOH HOH A . 
T 5 HOH 82  1482 470  HOH HOH A . 
T 5 HOH 83  1483 6    HOH HOH A . 
T 5 HOH 84  1484 173  HOH HOH A . 
T 5 HOH 85  1485 284  HOH HOH A . 
T 5 HOH 86  1486 225  HOH HOH A . 
T 5 HOH 87  1487 101  HOH HOH A . 
T 5 HOH 88  1488 6    HOH HOH A . 
T 5 HOH 89  1489 130  HOH HOH A . 
T 5 HOH 90  1490 216  HOH HOH A . 
T 5 HOH 91  1491 264  HOH HOH A . 
T 5 HOH 92  1492 212  HOH HOH A . 
T 5 HOH 93  1493 334  HOH HOH A . 
T 5 HOH 94  1494 363  HOH HOH A . 
T 5 HOH 95  1495 511  HOH HOH A . 
T 5 HOH 96  1496 226  HOH HOH A . 
T 5 HOH 97  1497 293  HOH HOH A . 
T 5 HOH 98  1498 84   HOH HOH A . 
T 5 HOH 99  1499 328  HOH HOH A . 
T 5 HOH 100 1500 29   HOH HOH A . 
T 5 HOH 101 1501 38   HOH HOH A . 
T 5 HOH 102 1502 109  HOH HOH A . 
T 5 HOH 103 1503 89   HOH HOH A . 
T 5 HOH 104 1504 466  HOH HOH A . 
T 5 HOH 105 1505 522  HOH HOH A . 
T 5 HOH 106 1506 441  HOH HOH A . 
T 5 HOH 107 1507 148  HOH HOH A . 
T 5 HOH 108 1508 194  HOH HOH A . 
T 5 HOH 109 1509 182  HOH HOH A . 
T 5 HOH 110 1510 159  HOH HOH A . 
T 5 HOH 111 1511 189  HOH HOH A . 
T 5 HOH 112 1512 432  HOH HOH A . 
T 5 HOH 113 1513 255  HOH HOH A . 
T 5 HOH 114 1514 250  HOH HOH A . 
T 5 HOH 115 1515 87   HOH HOH A . 
T 5 HOH 116 1516 453  HOH HOH A . 
T 5 HOH 117 1517 26   HOH HOH A . 
T 5 HOH 118 1518 74   HOH HOH A . 
T 5 HOH 119 1519 35   HOH HOH A . 
T 5 HOH 120 1520 22   HOH HOH A . 
T 5 HOH 121 1521 19   HOH HOH A . 
T 5 HOH 122 1522 100  HOH HOH A . 
T 5 HOH 123 1523 93   HOH HOH A . 
T 5 HOH 124 1524 36   HOH HOH A . 
T 5 HOH 125 1525 107  HOH HOH A . 
T 5 HOH 126 1526 177  HOH HOH A . 
T 5 HOH 127 1527 48   HOH HOH A . 
T 5 HOH 128 1528 34   HOH HOH A . 
T 5 HOH 129 1529 282  HOH HOH A . 
T 5 HOH 130 1530 92   HOH HOH A . 
T 5 HOH 131 1531 232  HOH HOH A . 
T 5 HOH 132 1532 471  HOH HOH A . 
T 5 HOH 133 1533 86   HOH HOH A . 
T 5 HOH 134 1534 190  HOH HOH A . 
T 5 HOH 135 1535 108  HOH HOH A . 
T 5 HOH 136 1536 263  HOH HOH A . 
T 5 HOH 137 1537 165  HOH HOH A . 
T 5 HOH 138 1538 25   HOH HOH A . 
T 5 HOH 139 1539 256  HOH HOH A . 
T 5 HOH 140 1540 111  HOH HOH A . 
T 5 HOH 141 1541 119  HOH HOH A . 
T 5 HOH 142 1542 314  HOH HOH A . 
T 5 HOH 143 1543 469  HOH HOH A . 
T 5 HOH 144 1544 11   HOH HOH A . 
T 5 HOH 145 1545 348  HOH HOH A . 
T 5 HOH 146 1546 78   HOH HOH A . 
T 5 HOH 147 1547 344  HOH HOH A . 
T 5 HOH 148 1548 439  HOH HOH A . 
T 5 HOH 149 1549 486  HOH HOH A . 
T 5 HOH 150 1550 169  HOH HOH A . 
T 5 HOH 151 1551 168  HOH HOH A . 
T 5 HOH 152 1552 267  HOH HOH A . 
T 5 HOH 153 1553 132  HOH HOH A . 
T 5 HOH 154 1554 385  HOH HOH A . 
T 5 HOH 155 1555 235  HOH HOH A . 
T 5 HOH 156 1556 45   HOH HOH A . 
T 5 HOH 157 1557 91   HOH HOH A . 
T 5 HOH 158 1558 350  HOH HOH A . 
T 5 HOH 159 1559 77   HOH HOH A . 
T 5 HOH 160 1560 121  HOH HOH A . 
T 5 HOH 161 1561 241  HOH HOH A . 
T 5 HOH 162 1562 68   HOH HOH A . 
T 5 HOH 163 1563 299  HOH HOH A . 
T 5 HOH 164 1564 245  HOH HOH A . 
T 5 HOH 165 1565 457  HOH HOH A . 
T 5 HOH 166 1566 255  HOH HOH A . 
T 5 HOH 167 1567 290  HOH HOH A . 
T 5 HOH 168 1568 204  HOH HOH A . 
T 5 HOH 169 1569 95   HOH HOH A . 
T 5 HOH 170 1570 237  HOH HOH A . 
T 5 HOH 171 1571 58   HOH HOH A . 
T 5 HOH 172 1572 24   HOH HOH A . 
T 5 HOH 173 1573 156  HOH HOH A . 
T 5 HOH 174 1574 139  HOH HOH A . 
T 5 HOH 175 1575 394  HOH HOH A . 
T 5 HOH 176 1576 101  HOH HOH A . 
T 5 HOH 177 1577 508  HOH HOH A . 
T 5 HOH 178 1578 201  HOH HOH A . 
T 5 HOH 179 1579 262  HOH HOH A . 
T 5 HOH 180 1580 17   HOH HOH A . 
T 5 HOH 181 1581 70   HOH HOH A . 
T 5 HOH 182 1582 261  HOH HOH A . 
T 5 HOH 183 1583 1    HOH HOH A . 
T 5 HOH 184 1584 175  HOH HOH A . 
T 5 HOH 185 1585 192  HOH HOH A . 
T 5 HOH 186 1586 496  HOH HOH A . 
T 5 HOH 187 1587 183  HOH HOH A . 
T 5 HOH 188 1588 340  HOH HOH A . 
T 5 HOH 189 1589 243  HOH HOH A . 
T 5 HOH 190 1590 30   HOH HOH A . 
T 5 HOH 191 1591 285  HOH HOH A . 
T 5 HOH 192 1592 541  HOH HOH A . 
T 5 HOH 193 1593 288  HOH HOH A . 
T 5 HOH 194 1594 127  HOH HOH A . 
T 5 HOH 195 1595 259  HOH HOH A . 
T 5 HOH 196 1596 189  HOH HOH A . 
T 5 HOH 197 1597 251  HOH HOH A . 
T 5 HOH 198 1598 49   HOH HOH A . 
T 5 HOH 199 1599 234  HOH HOH A . 
T 5 HOH 200 1600 341  HOH HOH A . 
T 5 HOH 201 1601 442  HOH HOH A . 
T 5 HOH 202 1602 26   HOH HOH A . 
T 5 HOH 203 1603 421  HOH HOH A . 
T 5 HOH 204 1604 176  HOH HOH A . 
T 5 HOH 205 1605 133  HOH HOH A . 
T 5 HOH 206 1606 14   HOH HOH A . 
T 5 HOH 207 1607 62   HOH HOH A . 
T 5 HOH 208 1608 242  HOH HOH A . 
T 5 HOH 209 1609 22   HOH HOH A . 
T 5 HOH 210 1610 194  HOH HOH A . 
T 5 HOH 211 1611 192  HOH HOH A . 
T 5 HOH 212 1612 60   HOH HOH A . 
T 5 HOH 213 1613 185  HOH HOH A . 
T 5 HOH 214 1614 374  HOH HOH A . 
T 5 HOH 215 1615 44   HOH HOH A . 
T 5 HOH 216 1616 482  HOH HOH A . 
T 5 HOH 217 1617 485  HOH HOH A . 
T 5 HOH 218 1618 430  HOH HOH A . 
T 5 HOH 219 1619 316  HOH HOH A . 
T 5 HOH 220 1620 234  HOH HOH A . 
T 5 HOH 221 1621 495  HOH HOH A . 
T 5 HOH 222 1622 505  HOH HOH A . 
T 5 HOH 223 1623 302  HOH HOH A . 
T 5 HOH 224 1624 85   HOH HOH A . 
T 5 HOH 225 1625 137  HOH HOH A . 
T 5 HOH 226 1626 429  HOH HOH A . 
T 5 HOH 227 1627 61   HOH HOH A . 
T 5 HOH 228 1628 80   HOH HOH A . 
T 5 HOH 229 1629 262  HOH HOH A . 
T 5 HOH 230 1630 188  HOH HOH A . 
T 5 HOH 231 1631 43   HOH HOH A . 
T 5 HOH 232 1632 43   HOH HOH A . 
T 5 HOH 233 1633 37   HOH HOH A . 
T 5 HOH 234 1634 40   HOH HOH A . 
T 5 HOH 235 1635 479  HOH HOH A . 
T 5 HOH 236 1636 214  HOH HOH A . 
T 5 HOH 237 1637 237  HOH HOH A . 
T 5 HOH 238 1638 89   HOH HOH A . 
T 5 HOH 239 1639 82   HOH HOH A . 
T 5 HOH 240 1640 327  HOH HOH A . 
T 5 HOH 241 1641 164  HOH HOH A . 
T 5 HOH 242 1642 48   HOH HOH A . 
T 5 HOH 243 1643 170  HOH HOH A . 
T 5 HOH 244 1644 412  HOH HOH A . 
T 5 HOH 245 1645 120  HOH HOH A . 
T 5 HOH 246 1646 398  HOH HOH A . 
T 5 HOH 247 1647 407  HOH HOH A . 
T 5 HOH 248 1648 525  HOH HOH A . 
T 5 HOH 249 1649 55   HOH HOH A . 
T 5 HOH 250 1650 134  HOH HOH A . 
T 5 HOH 251 1651 57   HOH HOH A . 
T 5 HOH 252 1652 422  HOH HOH A . 
T 5 HOH 253 1653 268  HOH HOH A . 
T 5 HOH 254 1654 492  HOH HOH A . 
T 5 HOH 255 1655 383  HOH HOH A . 
T 5 HOH 256 1656 513  HOH HOH A . 
T 5 HOH 257 1657 75   HOH HOH A . 
T 5 HOH 258 1658 533  HOH HOH A . 
T 5 HOH 259 1659 315  HOH HOH A . 
T 5 HOH 260 1660 419  HOH HOH A . 
T 5 HOH 261 1661 447  HOH HOH A . 
T 5 HOH 262 1662 342  HOH HOH A . 
T 5 HOH 263 1663 102  HOH HOH A . 
T 5 HOH 264 1664 181  HOH HOH A . 
T 5 HOH 265 1665 85   HOH HOH A . 
T 5 HOH 266 1666 252  HOH HOH A . 
T 5 HOH 267 1667 460  HOH HOH A . 
T 5 HOH 268 1668 309  HOH HOH A . 
T 5 HOH 269 1669 87   HOH HOH A . 
T 5 HOH 270 1670 499  HOH HOH A . 
T 5 HOH 271 1671 376  HOH HOH A . 
T 5 HOH 272 1672 395  HOH HOH A . 
T 5 HOH 273 1673 561  HOH HOH A . 
T 5 HOH 274 1674 346  HOH HOH A . 
T 5 HOH 275 1675 467  HOH HOH A . 
T 5 HOH 276 1676 117  HOH HOH A . 
T 5 HOH 277 1677 199  HOH HOH A . 
T 5 HOH 278 1678 253  HOH HOH A . 
T 5 HOH 279 1679 112  HOH HOH A . 
T 5 HOH 280 1680 493  HOH HOH A . 
T 5 HOH 281 1681 540  HOH HOH A . 
T 5 HOH 282 1682 520  HOH HOH A . 
T 5 HOH 283 1683 50   HOH HOH A . 
T 5 HOH 284 1684 258  HOH HOH A . 
T 5 HOH 285 1685 21   HOH HOH A . 
T 5 HOH 286 1686 503  HOH HOH A . 
T 5 HOH 287 1687 186  HOH HOH A . 
T 5 HOH 288 1688 291  HOH HOH A . 
T 5 HOH 289 1689 266  HOH HOH A . 
T 5 HOH 290 1690 443  HOH HOH A . 
T 5 HOH 291 1691 94   HOH HOH A . 
T 5 HOH 292 1692 317  HOH HOH A . 
T 5 HOH 293 1693 484  HOH HOH A . 
T 5 HOH 294 1694 70   HOH HOH A . 
T 5 HOH 295 1695 96   HOH HOH A . 
T 5 HOH 296 1696 51   HOH HOH A . 
T 5 HOH 297 1697 324  HOH HOH A . 
T 5 HOH 298 1698 461  HOH HOH A . 
T 5 HOH 299 1699 34   HOH HOH A . 
T 5 HOH 300 1700 178  HOH HOH A . 
T 5 HOH 301 1701 54   HOH HOH A . 
T 5 HOH 302 1702 289  HOH HOH A . 
T 5 HOH 303 1703 30   HOH HOH A . 
T 5 HOH 304 1704 63   HOH HOH A . 
T 5 HOH 305 1705 104  HOH HOH A . 
T 5 HOH 306 1706 65   HOH HOH A . 
T 5 HOH 307 1707 195  HOH HOH A . 
T 5 HOH 308 1708 459  HOH HOH A . 
T 5 HOH 309 1709 193  HOH HOH A . 
T 5 HOH 310 1710 91   HOH HOH A . 
T 5 HOH 311 1711 203  HOH HOH A . 
T 5 HOH 312 1712 180  HOH HOH A . 
T 5 HOH 313 1713 53   HOH HOH A . 
T 5 HOH 314 1714 103  HOH HOH A . 
T 5 HOH 315 1715 307  HOH HOH A . 
T 5 HOH 316 1716 110  HOH HOH A . 
T 5 HOH 317 1717 349  HOH HOH A . 
T 5 HOH 318 1718 213  HOH HOH A . 
T 5 HOH 319 1719 359  HOH HOH A . 
T 5 HOH 320 1720 162  HOH HOH A . 
T 5 HOH 321 1721 108  HOH HOH A . 
T 5 HOH 322 1722 264  HOH HOH A . 
T 5 HOH 323 1723 259  HOH HOH A . 
T 5 HOH 324 1724 187  HOH HOH A . 
T 5 HOH 325 1725 402  HOH HOH A . 
T 5 HOH 326 1726 420  HOH HOH A . 
T 5 HOH 327 1727 352  HOH HOH A . 
T 5 HOH 328 1728 437  HOH HOH A . 
T 5 HOH 329 1729 78   HOH HOH A . 
T 5 HOH 330 1730 209  HOH HOH A . 
T 5 HOH 331 1731 81   HOH HOH A . 
T 5 HOH 332 1732 292  HOH HOH A . 
T 5 HOH 333 1733 379  HOH HOH A . 
T 5 HOH 334 1734 488  HOH HOH A . 
T 5 HOH 335 1735 337  HOH HOH A . 
T 5 HOH 336 1736 198  HOH HOH A . 
T 5 HOH 337 1737 90   HOH HOH A . 
T 5 HOH 338 1738 109  HOH HOH A . 
T 5 HOH 339 1739 201  HOH HOH A . 
T 5 HOH 340 1740 77   HOH HOH A . 
T 5 HOH 341 1741 390  HOH HOH A . 
T 5 HOH 342 1742 236  HOH HOH A . 
T 5 HOH 343 1743 67   HOH HOH A . 
T 5 HOH 344 1744 277  HOH HOH A . 
T 5 HOH 345 1745 5    HOH HOH A . 
T 5 HOH 346 1746 29   HOH HOH A . 
T 5 HOH 347 1747 213  HOH HOH A . 
T 5 HOH 348 1748 113  HOH HOH A . 
T 5 HOH 349 1749 25   HOH HOH A . 
T 5 HOH 350 1750 95   HOH HOH A . 
T 5 HOH 351 1751 84   HOH HOH A . 
T 5 HOH 352 1752 68   HOH HOH A . 
T 5 HOH 353 1753 111  HOH HOH A . 
T 5 HOH 354 1754 97   HOH HOH A . 
T 5 HOH 355 1755 83   HOH HOH A . 
T 5 HOH 356 1756 161  HOH HOH A . 
T 5 HOH 357 1757 69   HOH HOH A . 
U 5 HOH 1   1401 119  HOH HOH B . 
U 5 HOH 2   1402 195  HOH HOH B . 
U 5 HOH 3   1403 438  HOH HOH B . 
U 5 HOH 4   1404 300  HOH HOH B . 
U 5 HOH 5   1405 164  HOH HOH B . 
U 5 HOH 6   1406 14   HOH HOH B . 
U 5 HOH 7   1407 103  HOH HOH B . 
U 5 HOH 8   1408 17   HOH HOH B . 
U 5 HOH 9   1409 9    HOH HOH B . 
U 5 HOH 10  1410 280  HOH HOH B . 
U 5 HOH 11  1411 310  HOH HOH B . 
U 5 HOH 12  1412 268  HOH HOH B . 
U 5 HOH 13  1413 530  HOH HOH B . 
U 5 HOH 14  1414 502  HOH HOH B . 
U 5 HOH 15  1415 143  HOH HOH B . 
U 5 HOH 16  1416 338  HOH HOH B . 
U 5 HOH 17  1417 67   HOH HOH B . 
U 5 HOH 18  1418 272  HOH HOH B . 
U 5 HOH 19  1419 208  HOH HOH B . 
U 5 HOH 20  1420 211  HOH HOH B . 
U 5 HOH 21  1421 487  HOH HOH B . 
U 5 HOH 22  1422 228  HOH HOH B . 
U 5 HOH 23  1423 179  HOH HOH B . 
U 5 HOH 24  1424 193  HOH HOH B . 
U 5 HOH 25  1425 139  HOH HOH B . 
U 5 HOH 26  1426 311  HOH HOH B . 
U 5 HOH 27  1427 553  HOH HOH B . 
U 5 HOH 28  1428 247  HOH HOH B . 
U 5 HOH 29  1429 135  HOH HOH B . 
U 5 HOH 30  1430 137  HOH HOH B . 
U 5 HOH 31  1431 275  HOH HOH B . 
U 5 HOH 32  1432 15   HOH HOH B . 
U 5 HOH 33  1433 308  HOH HOH B . 
U 5 HOH 34  1434 241  HOH HOH B . 
U 5 HOH 35  1435 436  HOH HOH B . 
U 5 HOH 36  1436 53   HOH HOH B . 
U 5 HOH 37  1437 426  HOH HOH B . 
U 5 HOH 38  1438 446  HOH HOH B . 
U 5 HOH 39  1439 448  HOH HOH B . 
U 5 HOH 40  1440 97   HOH HOH B . 
U 5 HOH 41  1441 400  HOH HOH B . 
U 5 HOH 42  1442 64   HOH HOH B . 
U 5 HOH 43  1443 329  HOH HOH B . 
U 5 HOH 44  1444 269  HOH HOH B . 
U 5 HOH 45  1445 63   HOH HOH B . 
U 5 HOH 46  1446 18   HOH HOH B . 
U 5 HOH 47  1447 370  HOH HOH B . 
U 5 HOH 48  1448 303  HOH HOH B . 
U 5 HOH 49  1449 131  HOH HOH B . 
U 5 HOH 50  1450 18   HOH HOH B . 
U 5 HOH 51  1451 42   HOH HOH B . 
U 5 HOH 52  1452 452  HOH HOH B . 
U 5 HOH 53  1453 417  HOH HOH B . 
U 5 HOH 54  1454 158  HOH HOH B . 
U 5 HOH 55  1455 229  HOH HOH B . 
U 5 HOH 56  1456 152  HOH HOH B . 
U 5 HOH 57  1457 171  HOH HOH B . 
U 5 HOH 58  1458 20   HOH HOH B . 
U 5 HOH 59  1459 431  HOH HOH B . 
U 5 HOH 60  1460 174  HOH HOH B . 
U 5 HOH 61  1461 75   HOH HOH B . 
U 5 HOH 62  1462 322  HOH HOH B . 
U 5 HOH 63  1463 4    HOH HOH B . 
U 5 HOH 64  1464 215  HOH HOH B . 
U 5 HOH 65  1465 321  HOH HOH B . 
U 5 HOH 66  1466 7    HOH HOH B . 
U 5 HOH 67  1467 127  HOH HOH B . 
U 5 HOH 68  1468 273  HOH HOH B . 
U 5 HOH 69  1469 155  HOH HOH B . 
U 5 HOH 70  1470 102  HOH HOH B . 
U 5 HOH 71  1471 125  HOH HOH B . 
U 5 HOH 72  1472 542  HOH HOH B . 
U 5 HOH 73  1473 219  HOH HOH B . 
U 5 HOH 74  1474 46   HOH HOH B . 
U 5 HOH 75  1475 274  HOH HOH B . 
U 5 HOH 76  1476 16   HOH HOH B . 
U 5 HOH 77  1477 82   HOH HOH B . 
U 5 HOH 78  1478 128  HOH HOH B . 
U 5 HOH 79  1479 144  HOH HOH B . 
U 5 HOH 80  1480 434  HOH HOH B . 
U 5 HOH 81  1481 271  HOH HOH B . 
U 5 HOH 82  1482 396  HOH HOH B . 
U 5 HOH 83  1483 96   HOH HOH B . 
U 5 HOH 84  1484 225  HOH HOH B . 
U 5 HOH 85  1485 172  HOH HOH B . 
U 5 HOH 86  1486 134  HOH HOH B . 
U 5 HOH 87  1487 73   HOH HOH B . 
U 5 HOH 88  1488 418  HOH HOH B . 
U 5 HOH 89  1489 160  HOH HOH B . 
U 5 HOH 90  1490 210  HOH HOH B . 
U 5 HOH 91  1491 146  HOH HOH B . 
U 5 HOH 92  1492 260  HOH HOH B . 
U 5 HOH 93  1493 154  HOH HOH B . 
U 5 HOH 94  1494 33   HOH HOH B . 
U 5 HOH 95  1495 353  HOH HOH B . 
U 5 HOH 96  1496 32   HOH HOH B . 
U 5 HOH 97  1497 205  HOH HOH B . 
U 5 HOH 98  1498 161  HOH HOH B . 
U 5 HOH 99  1499 57   HOH HOH B . 
U 5 HOH 100 1500 458  HOH HOH B . 
U 5 HOH 101 1501 278  HOH HOH B . 
U 5 HOH 102 1502 142  HOH HOH B . 
U 5 HOH 103 1503 236  HOH HOH B . 
U 5 HOH 104 1504 276  HOH HOH B . 
U 5 HOH 105 1505 27   HOH HOH B . 
U 5 HOH 106 1506 208  HOH HOH B . 
U 5 HOH 107 1507 369  HOH HOH B . 
U 5 HOH 108 1508 138  HOH HOH B . 
U 5 HOH 109 1509 51   HOH HOH B . 
U 5 HOH 110 1510 197  HOH HOH B . 
U 5 HOH 111 1511 464  HOH HOH B . 
U 5 HOH 112 1512 118  HOH HOH B . 
U 5 HOH 113 1513 94   HOH HOH B . 
U 5 HOH 114 1514 202  HOH HOH B . 
U 5 HOH 115 1515 233  HOH HOH B . 
U 5 HOH 116 1516 143  HOH HOH B . 
U 5 HOH 117 1517 49   HOH HOH B . 
U 5 HOH 118 1518 31   HOH HOH B . 
U 5 HOH 119 1519 521  HOH HOH B . 
U 5 HOH 120 1520 181  HOH HOH B . 
U 5 HOH 121 1521 174  HOH HOH B . 
U 5 HOH 122 1522 450  HOH HOH B . 
U 5 HOH 123 1523 86   HOH HOH B . 
U 5 HOH 124 1524 11   HOH HOH B . 
U 5 HOH 125 1525 141  HOH HOH B . 
U 5 HOH 126 1526 149  HOH HOH B . 
U 5 HOH 127 1527 230  HOH HOH B . 
U 5 HOH 128 1528 265  HOH HOH B . 
U 5 HOH 129 1529 206  HOH HOH B . 
U 5 HOH 130 1530 71   HOH HOH B . 
U 5 HOH 131 1531 72   HOH HOH B . 
U 5 HOH 132 1532 83   HOH HOH B . 
U 5 HOH 133 1533 454  HOH HOH B . 
U 5 HOH 134 1534 112  HOH HOH B . 
U 5 HOH 135 1535 149  HOH HOH B . 
U 5 HOH 136 1536 39   HOH HOH B . 
U 5 HOH 137 1537 287  HOH HOH B . 
U 5 HOH 138 1538 313  HOH HOH B . 
U 5 HOH 139 1539 145  HOH HOH B . 
U 5 HOH 140 1540 221  HOH HOH B . 
U 5 HOH 141 1541 391  HOH HOH B . 
U 5 HOH 142 1542 129  HOH HOH B . 
U 5 HOH 143 1543 76   HOH HOH B . 
U 5 HOH 144 1544 124  HOH HOH B . 
U 5 HOH 145 1545 242  HOH HOH B . 
U 5 HOH 146 1546 480  HOH HOH B . 
U 5 HOH 147 1547 104  HOH HOH B . 
U 5 HOH 148 1548 279  HOH HOH B . 
U 5 HOH 149 1549 123  HOH HOH B . 
U 5 HOH 150 1550 278  HOH HOH B . 
U 5 HOH 151 1551 98   HOH HOH B . 
U 5 HOH 152 1552 8    HOH HOH B . 
U 5 HOH 153 1553 69   HOH HOH B . 
U 5 HOH 154 1554 44   HOH HOH B . 
U 5 HOH 155 1555 212  HOH HOH B . 
U 5 HOH 156 1556 246  HOH HOH B . 
U 5 HOH 157 1557 325  HOH HOH B . 
U 5 HOH 158 1558 240  HOH HOH B . 
U 5 HOH 159 1559 99   HOH HOH B . 
U 5 HOH 160 1560 106  HOH HOH B . 
U 5 HOH 161 1561 105  HOH HOH B . 
U 5 HOH 162 1562 463  HOH HOH B . 
U 5 HOH 163 1563 54   HOH HOH B . 
U 5 HOH 164 1564 52   HOH HOH B . 
U 5 HOH 165 1565 61   HOH HOH B . 
U 5 HOH 166 1566 509  HOH HOH B . 
U 5 HOH 167 1567 182  HOH HOH B . 
U 5 HOH 168 1568 204  HOH HOH B . 
U 5 HOH 169 1569 354  HOH HOH B . 
U 5 HOH 170 1570 500  HOH HOH B . 
U 5 HOH 171 1571 65   HOH HOH B . 
U 5 HOH 172 1572 243  HOH HOH B . 
U 5 HOH 173 1573 518  HOH HOH B . 
U 5 HOH 174 1574 171  HOH HOH B . 
U 5 HOH 175 1575 41   HOH HOH B . 
U 5 HOH 176 1576 37   HOH HOH B . 
U 5 HOH 177 1577 399  HOH HOH B . 
U 5 HOH 178 1578 244  HOH HOH B . 
U 5 HOH 179 1579 187  HOH HOH B . 
U 5 HOH 180 1580 256  HOH HOH B . 
U 5 HOH 181 1581 128  HOH HOH B . 
U 5 HOH 182 1582 185  HOH HOH B . 
U 5 HOH 183 1583 228  HOH HOH B . 
U 5 HOH 184 1584 411  HOH HOH B . 
U 5 HOH 185 1585 71   HOH HOH B . 
U 5 HOH 186 1586 220  HOH HOH B . 
U 5 HOH 187 1587 306  HOH HOH B . 
U 5 HOH 188 1588 21   HOH HOH B . 
U 5 HOH 189 1589 501  HOH HOH B . 
U 5 HOH 190 1590 319  HOH HOH B . 
U 5 HOH 191 1591 121  HOH HOH B . 
U 5 HOH 192 1592 50   HOH HOH B . 
U 5 HOH 193 1593 244  HOH HOH B . 
U 5 HOH 194 1594 356  HOH HOH B . 
U 5 HOH 195 1595 323  HOH HOH B . 
U 5 HOH 196 1596 210  HOH HOH B . 
U 5 HOH 197 1597 474  HOH HOH B . 
U 5 HOH 198 1598 226  HOH HOH B . 
U 5 HOH 199 1599 117  HOH HOH B . 
U 5 HOH 200 1600 546  HOH HOH B . 
U 5 HOH 201 1601 214  HOH HOH B . 
U 5 HOH 202 1602 506  HOH HOH B . 
U 5 HOH 203 1603 38   HOH HOH B . 
U 5 HOH 204 1604 56   HOH HOH B . 
U 5 HOH 205 1605 203  HOH HOH B . 
U 5 HOH 206 1606 35   HOH HOH B . 
U 5 HOH 207 1607 273  HOH HOH B . 
U 5 HOH 208 1608 401  HOH HOH B . 
U 5 HOH 209 1609 472  HOH HOH B . 
U 5 HOH 210 1610 277  HOH HOH B . 
U 5 HOH 211 1611 403  HOH HOH B . 
U 5 HOH 212 1612 169  HOH HOH B . 
U 5 HOH 213 1613 286  HOH HOH B . 
U 5 HOH 214 1614 473  HOH HOH B . 
U 5 HOH 215 1615 20   HOH HOH B . 
U 5 HOH 216 1616 451  HOH HOH B . 
U 5 HOH 217 1617 318  HOH HOH B . 
U 5 HOH 218 1618 131  HOH HOH B . 
U 5 HOH 219 1619 455  HOH HOH B . 
U 5 HOH 220 1620 562  HOH HOH B . 
U 5 HOH 221 1621 196  HOH HOH B . 
U 5 HOH 222 1622 381  HOH HOH B . 
U 5 HOH 223 1623 125  HOH HOH B . 
U 5 HOH 224 1624 140  HOH HOH B . 
U 5 HOH 225 1625 358  HOH HOH B . 
U 5 HOH 226 1626 266  HOH HOH B . 
U 5 HOH 227 1627 550  HOH HOH B . 
U 5 HOH 228 1628 368  HOH HOH B . 
U 5 HOH 229 1629 528  HOH HOH B . 
U 5 HOH 230 1630 33   HOH HOH B . 
U 5 HOH 231 1631 209  HOH HOH B . 
U 5 HOH 232 1632 483  HOH HOH B . 
U 5 HOH 233 1633 162  HOH HOH B . 
U 5 HOH 234 1634 512  HOH HOH B . 
U 5 HOH 235 1635 146  HOH HOH B . 
U 5 HOH 236 1636 231  HOH HOH B . 
U 5 HOH 237 1637 23   HOH HOH B . 
U 5 HOH 238 1638 247  HOH HOH B . 
U 5 HOH 239 1639 224  HOH HOH B . 
U 5 HOH 240 1640 246  HOH HOH B . 
U 5 HOH 241 1641 428  HOH HOH B . 
U 5 HOH 242 1642 257  HOH HOH B . 
U 5 HOH 243 1643 141  HOH HOH B . 
U 5 HOH 244 1644 372  HOH HOH B . 
U 5 HOH 245 1645 364  HOH HOH B . 
U 5 HOH 246 1646 425  HOH HOH B . 
U 5 HOH 247 1647 218  HOH HOH B . 
U 5 HOH 248 1648 507  HOH HOH B . 
U 5 HOH 249 1649 475  HOH HOH B . 
U 5 HOH 250 1650 10   HOH HOH B . 
U 5 HOH 251 1651 248  HOH HOH B . 
U 5 HOH 252 1652 126  HOH HOH B . 
U 5 HOH 253 1653 148  HOH HOH B . 
U 5 HOH 254 1654 462  HOH HOH B . 
U 5 HOH 255 1655 231  HOH HOH B . 
U 5 HOH 256 1656 39   HOH HOH B . 
U 5 HOH 257 1657 444  HOH HOH B . 
U 5 HOH 258 1658 145  HOH HOH B . 
U 5 HOH 259 1659 156  HOH HOH B . 
U 5 HOH 260 1660 498  HOH HOH B . 
U 5 HOH 261 1661 166  HOH HOH B . 
U 5 HOH 262 1662 114  HOH HOH B . 
U 5 HOH 263 1663 41   HOH HOH B . 
U 5 HOH 264 1664 559  HOH HOH B . 
U 5 HOH 265 1665 132  HOH HOH B . 
U 5 HOH 266 1666 298  HOH HOH B . 
U 5 HOH 267 1667 531  HOH HOH B . 
U 5 HOH 268 1668 136  HOH HOH B . 
U 5 HOH 269 1669 440  HOH HOH B . 
U 5 HOH 270 1670 365  HOH HOH B . 
U 5 HOH 271 1671 249  HOH HOH B . 
U 5 HOH 272 1672 375  HOH HOH B . 
U 5 HOH 273 1673 159  HOH HOH B . 
U 5 HOH 274 1674 552  HOH HOH B . 
U 5 HOH 275 1675 230  HOH HOH B . 
U 5 HOH 276 1676 304  HOH HOH B . 
U 5 HOH 277 1677 142  HOH HOH B . 
U 5 HOH 278 1678 389  HOH HOH B . 
U 5 HOH 279 1679 4    HOH HOH B . 
U 5 HOH 280 1680 217  HOH HOH B . 
U 5 HOH 281 1681 468  HOH HOH B . 
U 5 HOH 282 1682 250  HOH HOH B . 
U 5 HOH 283 1683 47   HOH HOH B . 
U 5 HOH 284 1684 222  HOH HOH B . 
U 5 HOH 285 1685 40   HOH HOH B . 
U 5 HOH 286 1686 130  HOH HOH B . 
U 5 HOH 287 1687 138  HOH HOH B . 
U 5 HOH 288 1688 481  HOH HOH B . 
U 5 HOH 289 1689 154  HOH HOH B . 
U 5 HOH 290 1690 216  HOH HOH B . 
U 5 HOH 291 1691 144  HOH HOH B . 
U 5 HOH 292 1692 221  HOH HOH B . 
U 5 HOH 293 1693 549  HOH HOH B . 
U 5 HOH 294 1694 551  HOH HOH B . 
U 5 HOH 295 1695 252  HOH HOH B . 
U 5 HOH 296 1696 393  HOH HOH B . 
U 5 HOH 297 1697 227  HOH HOH B . 
U 5 HOH 298 1698 478  HOH HOH B . 
U 5 HOH 299 1699 351  HOH HOH B . 
U 5 HOH 300 1700 361  HOH HOH B . 
U 5 HOH 301 1701 357  HOH HOH B . 
U 5 HOH 302 1702 331  HOH HOH B . 
U 5 HOH 303 1703 548  HOH HOH B . 
U 5 HOH 304 1704 151  HOH HOH B . 
U 5 HOH 305 1705 206  HOH HOH B . 
U 5 HOH 306 1706 150  HOH HOH B . 
U 5 HOH 307 1707 347  HOH HOH B . 
U 5 HOH 308 1708 31   HOH HOH B . 
U 5 HOH 309 1709 423  HOH HOH B . 
U 5 HOH 310 1710 360  HOH HOH B . 
U 5 HOH 311 1711 179  HOH HOH B . 
U 5 HOH 312 1712 207  HOH HOH B . 
U 5 HOH 313 1713 3    HOH HOH B . 
U 5 HOH 314 1714 157  HOH HOH B . 
U 5 HOH 315 1715 491  HOH HOH B . 
U 5 HOH 316 1716 36   HOH HOH B . 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,E,F,G,H,I,J,K,L,M,N,O,P,T 
2 1 B,Q,R,S,U                       
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2021-03-03 
2 'Structure model' 2 0 2021-03-17 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references'     
2 2 'Structure model' 'Non-polymer description' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' chem_comp 
2 2 'Structure model' citation  
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_chem_comp.formula'                
2 2 'Structure model' '_citation.journal_volume'          
3 2 'Structure model' '_citation.page_first'              
4 2 'Structure model' '_citation.page_last'               
5 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
6 2 'Structure model' '_citation.title'                   
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0267 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_pdbx_entry_details.entry_id                 7ATD 
_pdbx_entry_details.nonpolymer_details       ? 
_pdbx_entry_details.sequence_details         ? 
_pdbx_entry_details.compound_details         ? 
_pdbx_entry_details.source_details           ? 
_pdbx_entry_details.has_ligand_of_interest   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O A HOH 1415 ? ? O A HOH 1640 ? ? 1.70 
2  1 O B HOH 1501 ? ? O B HOH 1533 ? ? 1.77 
3  1 O B HOH 1568 ? ? O B HOH 1667 ? ? 1.78 
4  1 O B HOH 1555 ? ? O B HOH 1682 ? ? 1.78 
5  1 O B HOH 1613 ? ? O B HOH 1667 ? ? 1.88 
6  1 O B HOH 1501 ? ? O B HOH 1527 ? ? 2.02 
7  1 O B HOH 1557 ? ? O B HOH 1628 ? ? 2.07 
8  1 O B HOH 1401 ? ? O B HOH 1577 ? ? 2.07 
9  1 O A HOH 1407 ? ? O A HOH 1646 ? ? 2.12 
10 1 O A HOH 1434 ? ? O A HOH 1648 ? ? 2.12 
11 1 O A HOH 1404 ? ? O A HOH 1573 ? ? 2.13 
12 1 O B HOH 1601 ? ? O B HOH 1646 ? ? 2.17 
13 1 O A ARG 17   ? ? O A HOH 1401 ? ? 2.17 
14 1 O A HOH 1417 ? ? O A HOH 1710 ? ? 2.18 
15 1 O B HOH 1423 ? ? O B HOH 1508 ? ? 2.18 
16 1 O A HOH 1473 ? ? O A HOH 1726 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    B 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1404 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1546 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   3_644 
_pdbx_validate_symm_contact.dist              2.06 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 144 ? ? 60.83  -123.25 
2 1 PRO A 219 ? ? -69.87 0.05    
3 1 ALA A 237 ? ? -95.80 51.42   
4 1 ASP A 265 ? ? 74.58  -0.24   
5 1 ALA B 144 ? ? 61.24  -122.88 
6 1 ALA B 237 ? ? -98.30 47.49   
7 1 ASP B 265 ? ? 75.92  -2.51   
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1752 ? 6.30 . 
2 1 O ? A HOH 1753 ? 6.37 . 
3 1 O ? A HOH 1754 ? 6.56 . 
4 1 O ? A HOH 1755 ? 6.79 . 
5 1 O ? A HOH 1756 ? 8.05 . 
6 1 O ? A HOH 1757 ? 9.65 . 
7 1 O ? B HOH 1716 ? 6.71 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 1 ? A MET 1 
2 1 Y 1 B MET 1 ? B MET 1 
# 
_pdbx_audit_support.funding_organization   'Spanish Ministry of Economy and Competitiveness' 
_pdbx_audit_support.country                Spain 
_pdbx_audit_support.grant_number           BFU2017-90030-P 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        RXH 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   RXH 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'FORMIC ACID'           FMT 
3 'ACETATE ION'           ACT 
4 'Naproxen Methyl Ester' RXH 
5 water                   HOH 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
