data_2GXB
# 
_entry.id   2GXB 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.281 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
PDB   2GXB         
NDB   PR0210       
RCSB  RCSB037662   
WWPDB D_1000037662 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.db_id 
_pdbx_database_related.details 
_pdbx_database_related.content_type 
PDB 1QBJ 'Za/Z-DNA complex'    unspecified 
PDB 1XMK 'Zb domain'           unspecified 
PDB 1QJP 'NMR structure of Za' unspecified 
# 
_pdbx_database_status.entry_id                        2GXB 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.recvd_initial_deposition_date   2006-05-08 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.status_code_cs                  ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
'Athanasiadis, A.' 1 
'Placido, D.'      2 
'Rich, A.'         3 
# 
loop_
_citation.id 
_citation.title 
_citation.journal_abbrev 
_citation.journal_volume 
_citation.page_first 
_citation.page_last 
_citation.year 
_citation.journal_id_ASTM 
_citation.country 
_citation.journal_id_ISSN 
_citation.journal_id_CSD 
_citation.book_publisher 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_DOI 
primary 'A Left-Handed RNA Double Helix Bound by the Zalpha Domain of the RNA-Editing Enzyme ADAR1.'           Structure 15  395  
404  2007 STRUE6 UK 0969-2126 2005 ? 17437712 10.1016/j.str.2007.03.001 
1       'Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.' Science   284 1841 
1845 1999 SCIEAS US 0036-8075 0038 ? ?        ?                         
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
primary 'Placido, D.'      1 
primary 'Brown, B.A.'      2 
primary 'Lowenhaupt, K.'   3 
primary 'Rich, A.'         4 
primary 'Athanasiadis, A.' 5 
# 
_cell.entry_id           2GXB 
_cell.length_a           73.603 
_cell.length_b           92.776 
_cell.length_c           50.229 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              16 
_cell.pdbx_unique_axis   ? 
_cell.length_a_esd       ? 
_cell.length_b_esd       ? 
_cell.length_c_esd       ? 
_cell.angle_alpha_esd    ? 
_cell.angle_beta_esd     ? 
_cell.angle_gamma_esd    ? 
# 
_symmetry.entry_id                         2GXB 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     syn "5'-R(P*(DU)P*CP*GP*CP*GP*CP*G)-3'"                2196.372 2   ?       ? ?           ? 
2 polymer     man 'Double-stranded RNA-specific adenosine deaminase' 7315.534 2   3.5.4.- ? 'Za Domain' ? 
3 non-polymer syn 'SODIUM ION'                                       22.990   3   ?       ? ?           ? 
4 water       nat water                                              18.015   157 ?       ? ?           ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        
'DRADA, 136 kDa double-stranded RNA-binding protein, P136, K88DSRBP, Interferon-inducible protein 4, IFI-4 protein' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 polyribonucleotide no no '(DU)CGCGCG'                                                       UCGCGCG E,F ? 
2 'polypeptide(L)'   no no SHMEQRILKFLEELGEGKATTAHDLSGKLGTPKKEINRVLYSLAKKGKLQKEAGTPPLWKIAVSTQ 
SHMEQRILKFLEELGEGKATTAHDLSGKLGTPKKEINRVLYSLAKKGKLQKEAGTPPLWKIAVSTQ A,B ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  DU  n 
1 2  C   n 
1 3  G   n 
1 4  C   n 
1 5  G   n 
1 6  C   n 
1 7  G   n 
2 1  SER n 
2 2  HIS n 
2 3  MET n 
2 4  GLU n 
2 5  GLN n 
2 6  ARG n 
2 7  ILE n 
2 8  LEU n 
2 9  LYS n 
2 10 PHE n 
2 11 LEU n 
2 12 GLU n 
2 13 GLU n 
2 14 LEU n 
2 15 GLY n 
2 16 GLU n 
2 17 GLY n 
2 18 LYS n 
2 19 ALA n 
2 20 THR n 
2 21 THR n 
2 22 ALA n 
2 23 HIS n 
2 24 ASP n 
2 25 LEU n 
2 26 SER n 
2 27 GLY n 
2 28 LYS n 
2 29 LEU n 
2 30 GLY n 
2 31 THR n 
2 32 PRO n 
2 33 LYS n 
2 34 LYS n 
2 35 GLU n 
2 36 ILE n 
2 37 ASN n 
2 38 ARG n 
2 39 VAL n 
2 40 LEU n 
2 41 TYR n 
2 42 SER n 
2 43 LEU n 
2 44 ALA n 
2 45 LYS n 
2 46 LYS n 
2 47 GLY n 
2 48 LYS n 
2 49 LEU n 
2 50 GLN n 
2 51 LYS n 
2 52 GLU n 
2 53 ALA n 
2 54 GLY n 
2 55 THR n 
2 56 PRO n 
2 57 PRO n 
2 58 LEU n 
2 59 TRP n 
2 60 LYS n 
2 61 ILE n 
2 62 ALA n 
2 63 VAL n 
2 64 SER n 
2 65 THR n 
2 66 GLN n 
# 
_entity_src_gen.entity_id                          2 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      ? 
_entity_src_gen.pdbx_beg_seq_num                   ? 
_entity_src_gen.pdbx_end_seq_num                   ? 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     Homo 
_entity_src_gen.pdbx_gene_src_gene                 'ADAR, ADAR1, DSRAD, IFI4' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     511693 
_entity_src_gen.host_org_genus                     Escherichia 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   'Escherichia coli' 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               BL21 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       PET28 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
_struct_ref.pdbx_db_isoform 
1 UNP DSRAD_HUMAN P55265 2 EQRILKFLEELGEGKATTAHDLSGKLGTPKKEINRVLYSLAKKGKLQKEAGTPPLWKIAVSTQ 140 ? 
2 PDB 2GXB        2GXB   1 ?                                                               ?   ? 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 2GXB A 4 ? 66 ? P55265 140 ? 202 ? 140 202 
2 1 2GXB B 4 ? 66 ? P55265 140 ? 202 ? 140 202 
3 2 2GXB E 1 ? 7  ? 2GXB   0   ? 6   ? 0   6   
4 2 2GXB F 1 ? 7  ? 2GXB   0   ? 6   ? 0   6   
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 2GXB SER A 1 ? UNP P55265 ? ? 'CLONING ARTIFACT' 137 1 
1 2GXB HIS A 2 ? UNP P55265 ? ? 'CLONING ARTIFACT' 138 2 
1 2GXB MET A 3 ? UNP P55265 ? ? 'CLONING ARTIFACT' 139 3 
2 2GXB SER B 1 ? UNP P55265 ? ? 'CLONING ARTIFACT' 137 4 
2 2GXB HIS B 2 ? UNP P55265 ? ? 'CLONING ARTIFACT' 138 5 
2 2GXB MET B 3 ? UNP P55265 ? ? 'CLONING ARTIFACT' 139 6 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                            ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                           ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                         ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                    ? 'C4 H7 N O4'      133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"        ? 'C9 H14 N3 O8 P'  323.197 
DU  'DNA linking'       y "2'-DEOXYURIDINE-5'-MONOPHOSPHATE" ? 'C9 H13 N2 O8 P'  308.182 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE"       ? 'C10 H14 N5 O8 P' 363.221 
GLN 'L-peptide linking' y GLUTAMINE                          ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                    ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                            ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                          ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                              ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                         ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                            ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                             ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                         ? 'C5 H11 N O2 S'   149.211 
NA  non-polymer         . 'SODIUM ION'                       ? 'Na 1'            22.990  
PHE 'L-peptide linking' y PHENYLALANINE                      ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                            ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                             ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                          ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                         ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                           ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                             ? 'C5 H11 N O2'     117.146 
# 
_exptl.entry_id          2GXB 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.25 
_exptl_crystal.density_percent_sol   45.41 
_exptl_crystal.description           ? 
_exptl_crystal.F_000                 ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.temp            292 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pH              3.6 
_exptl_crystal_grow.pdbx_details    '40% PEG600, 100mM Sodium Acetate, pH 3.6, VAPOR DIFFUSION, HANGING DROP, temperature 292K' 
_exptl_crystal_grow.pdbx_pH_range   . 
# 
loop_
_exptl_crystal_grow_comp.crystal_id 
_exptl_crystal_grow_comp.id 
_exptl_crystal_grow_comp.sol_id 
_exptl_crystal_grow_comp.name 
_exptl_crystal_grow_comp.conc 
_exptl_crystal_grow_comp.volume 
_exptl_crystal_grow_comp.details 
1 1 1 PEG600           ? ? ? 
1 2 1 'Sodium Acetate' ? ? ? 
1 3 1 H2O              ? ? ? 
1 4 2 PEG600           ? ? ? 
1 5 2 'Sodium Acetate' ? ? ? 
1 6 2 H2O              ? ? ? 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.ambient_temp_details   ? 
_diffrn.crystal_id             1 
# 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.detector               CCD 
_diffrn_detector.type                   'ADSC QUANTUM 315' 
_diffrn_detector.pdbx_collection_date   2005-10-21 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'APS BEAMLINE 19-ID' 
_diffrn_source.pdbx_synchrotron_site       APS 
_diffrn_source.pdbx_synchrotron_beamline   19-ID 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_wavelength_list        0.97 
# 
_reflns.entry_id                     2GXB 
_reflns.observed_criterion_sigma_I   0 
_reflns.observed_criterion_sigma_F   0 
_reflns.d_resolution_low             25.00 
_reflns.d_resolution_high            2.25 
_reflns.number_obs                   7511 
_reflns.number_all                   ? 
_reflns.percent_possible_obs         90.7 
_reflns.pdbx_Rmerge_I_obs            ? 
_reflns.pdbx_Rsym_value              0.075 
_reflns.pdbx_netI_over_sigmaI        ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_redundancy              5.1 
_reflns.R_free_details               ? 
_reflns.pdbx_chi_squared             ? 
_reflns.pdbx_scaling_rejects         ? 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
# 
_reflns_shell.d_res_high             2.25 
_reflns_shell.d_res_low              2.308 
_reflns_shell.percent_possible_all   92.5 
_reflns_shell.Rmerge_I_obs           ? 
_reflns_shell.pdbx_Rsym_value        0.197 
_reflns_shell.meanI_over_sigI_obs    ? 
_reflns_shell.pdbx_redundancy        5.1 
_reflns_shell.percent_possible_obs   ? 
_reflns_shell.number_unique_all      ? 
_reflns_shell.number_measured_all    ? 
_reflns_shell.number_measured_obs    ? 
_reflns_shell.number_unique_obs      ? 
_reflns_shell.pdbx_chi_squared       ? 
_reflns_shell.pdbx_diffrn_id         ? 
_reflns_shell.pdbx_ordinal           1 
# 
_refine.entry_id                                 2GXB 
_refine.ls_number_reflns_obs                     6769 
_refine.ls_number_reflns_all                     7499 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             25.00 
_refine.ls_d_res_high                            2.25 
_refine.ls_percent_reflns_obs                    88.47 
_refine.ls_R_factor_obs                          0.19908 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19436 
_refine.ls_R_factor_R_free                       0.24392 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 9.7 
_refine.ls_number_reflns_R_free                  730 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.936 
_refine.correlation_coeff_Fo_to_Fc_free          0.889 
_refine.B_iso_mean                               19.895 
_refine.aniso_B[1][1]                            -0.93 
_refine.aniso_B[2][2]                            -1.01 
_refine.aniso_B[3][3]                            1.95 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            0.00 
_refine.solvent_model_details                    'BABINET MODEL WITH MASK' 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      'PDB entry: 1QBJ' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             Isotropic 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.522 
_refine.pdbx_overall_ESU_R_Free                  0.270 
_refine.overall_SU_ML                            0.161 
_refine.overall_SU_B                             6.377 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        968 
_refine_hist.pdbx_number_atoms_nucleic_acid   277 
_refine_hist.pdbx_number_atoms_ligand         3 
_refine_hist.number_atoms_solvent             157 
_refine_hist.number_atoms_total               1405 
_refine_hist.d_res_high                       2.25 
_refine_hist.d_res_low                        25.00 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.007  0.022  ? 1291 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.000  0.020  ? 1055 'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.198  2.272  ? 1792 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            2.783  3.000  ? 2512 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       4.848  5.000  ? 123  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       38.482 24.848 ? 33   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       18.361 15.000 ? 205  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       25.514 15.000 ? 4    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.053  0.200  ? 213  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.003  0.020  ? 1170 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 167  'X-RAY DIFFRACTION' ? 
r_nbd_refined                0.210  0.200  ? 264  'X-RAY DIFFRACTION' ? 
r_nbd_other                  0.209  0.200  ? 911  'X-RAY DIFFRACTION' ? 
r_nbtor_refined              0.185  0.200  ? 537  'X-RAY DIFFRACTION' ? 
r_nbtor_other                0.099  0.200  ? 590  'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        0.188  0.200  ? 94   'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          0.094  0.200  ? 4    'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       0.256  0.200  ? 23   'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         0.233  0.200  ? 50   'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     0.101  0.200  ? 5    'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_mcbond_it                  0.705  1.500  ? 617  'X-RAY DIFFRACTION' ? 
r_mcbond_other               0.025  1.500  ? 260  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 1.360  2.000  ? 983  'X-RAY DIFFRACTION' ? 
r_scbond_it                  1.868  3.000  ? 731  'X-RAY DIFFRACTION' ? 
r_scangle_it                 2.985  4.500  ? 809  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?    'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       2.250 
_refine_ls_shell.d_res_low                        2.308 
_refine_ls_shell.number_reflns_R_work             501 
_refine_ls_shell.R_factor_R_work                  0.216 
_refine_ls_shell.percent_reflns_obs               90.91 
_refine_ls_shell.R_factor_R_free                  0.364 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             59 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
# 
_struct.entry_id                  2GXB 
_struct.title                     'Crystal Structure of The Za Domain bound to Z-RNA' 
_struct.pdbx_descriptor           'Double-stranded RNA-specific adenosine deaminase/RNA Complex' 
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        2GXB 
_struct_keywords.pdbx_keywords   hydrolase/RNA 
_struct_keywords.text            'Z-RNA, Za, ADAR1, RNA editing, PROTEIN-RNA complex, hydrolase-RNA COMPLEX' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 4 ? 
I N N 4 ? 
J N N 4 ? 
K N N 4 ? 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 1 SER C 1  ? GLY C 15 ? SER A 137 GLY A 151 1 ? 15 
HELX_P HELX_P2 2 THR C 21 ? GLY C 30 ? THR A 157 GLY A 166 1 ? 10 
HELX_P HELX_P3 3 PRO C 32 ? LYS C 46 ? PRO A 168 LYS A 182 1 ? 15 
HELX_P HELX_P4 4 MET D 3  ? LEU D 14 ? MET B 139 LEU B 150 1 ? 12 
HELX_P HELX_P5 5 THR D 21 ? GLY D 30 ? THR B 157 GLY B 166 1 ? 10 
HELX_P HELX_P6 6 PRO D 32 ? LYS D 46 ? PRO B 168 LYS B 182 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
metalc1  metalc ? ? G NA  .  NA  ? ? ? 1_555 B C   4 OP1   ? ? B NA  203 F C   3   1_555 ? ? ? ? ? ? ?            2.552 ? 
metalc2  metalc ? ? E NA  .  NA  ? ? ? 1_555 A C   6 "O2'" ? ? E NA  162 E C   5   1_555 ? ? ? ? ? ? ?            2.355 ? 
metalc3  metalc ? ? E NA  .  NA  ? ? ? 1_555 H HOH . O     ? ? E NA  162 E HOH 61  1_555 ? ? ? ? ? ? ?            2.244 ? 
metalc4  metalc ? ? E NA  .  NA  ? ? ? 1_555 B C   4 "O2'" ? ? E NA  162 F C   3   1_555 ? ? ? ? ? ? ?            2.452 ? 
metalc5  metalc ? ? F NA  .  NA  ? ? ? 1_555 B C   6 "O2'" ? ? F NA  163 F C   5   1_555 ? ? ? ? ? ? ?            2.368 ? 
metalc6  metalc ? ? F NA  .  NA  ? ? ? 1_555 A C   4 "O2'" ? ? F NA  163 E C   3   1_555 ? ? ? ? ? ? ?            2.355 ? 
metalc7  metalc ? ? F NA  .  NA  ? ? ? 1_555 B C   6 O2    ? ? F NA  163 F C   5   1_555 ? ? ? ? ? ? ?            2.469 ? 
metalc8  metalc ? ? A C   4  O2  ? ? ? 1_555 F NA  . NA    ? ? E C   3   F NA  163 1_555 ? ? ? ? ? ? ?            2.797 ? 
metalc9  metalc ? ? A C   6  O2  ? ? ? 1_555 E NA  . NA    ? ? E C   5   E NA  162 1_555 ? ? ? ? ? ? ?            2.648 ? 
metalc10 metalc ? ? B C   4  O2  ? ? ? 1_555 E NA  . NA    ? ? F C   3   E NA  162 1_555 ? ? ? ? ? ? ?            2.628 ? 
metalc11 metalc ? ? D ASN 37 OD1 ? ? ? 1_555 G NA  . NA    ? ? B ASN 173 B NA  203 1_555 ? ? ? ? ? ? ?            2.880 ? 
metalc12 metalc ? ? G NA  .  NA  ? ? ? 1_555 K HOH . O     ? ? B NA  203 B HOH 211 1_555 ? ? ? ? ? ? ?            2.777 ? 
metalc13 metalc ? ? F NA  .  NA  ? ? ? 1_555 I HOH . O     ? ? F NA  163 F HOH 189 1_555 ? ? ? ? ? ? ?            2.739 ? 
hydrog1  hydrog ? ? A C   2  N3  ? ? ? 1_555 B G   7 N1    ? ? E C   1   F G   6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog2  hydrog ? ? A C   2  N4  ? ? ? 1_555 B G   7 O6    ? ? E C   1   F G   6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog3  hydrog ? ? A C   2  O2  ? ? ? 1_555 B G   7 N2    ? ? E C   1   F G   6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog4  hydrog ? ? A G   3  N1  ? ? ? 1_555 B C   6 N3    ? ? E G   2   F C   5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog5  hydrog ? ? A G   3  N2  ? ? ? 1_555 B C   6 O2    ? ? E G   2   F C   5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog6  hydrog ? ? A G   3  O6  ? ? ? 1_555 B C   6 N4    ? ? E G   2   F C   5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog7  hydrog ? ? A C   4  N3  ? ? ? 1_555 B G   5 N1    ? ? E C   3   F G   4   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog8  hydrog ? ? A C   4  N4  ? ? ? 1_555 B G   5 O6    ? ? E C   3   F G   4   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog9  hydrog ? ? A C   4  O2  ? ? ? 1_555 B G   5 N2    ? ? E C   3   F G   4   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog10 hydrog ? ? A G   5  N1  ? ? ? 1_555 B C   4 N3    ? ? E G   4   F C   3   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog11 hydrog ? ? A G   5  N2  ? ? ? 1_555 B C   4 O2    ? ? E G   4   F C   3   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog12 hydrog ? ? A G   5  O6  ? ? ? 1_555 B C   4 N4    ? ? E G   4   F C   3   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog13 hydrog ? ? A C   6  N3  ? ? ? 1_555 B G   3 N1    ? ? E C   5   F G   2   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog14 hydrog ? ? A C   6  N4  ? ? ? 1_555 B G   3 O6    ? ? E C   5   F G   2   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog15 hydrog ? ? A C   6  O2  ? ? ? 1_555 B G   3 N2    ? ? E C   5   F G   2   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog16 hydrog ? ? A G   7  N1  ? ? ? 1_555 B C   2 N3    ? ? E G   6   F C   1   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog17 hydrog ? ? A G   7  N2  ? ? ? 1_555 B C   2 O2    ? ? E G   6   F C   1   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
hydrog18 hydrog ? ? A G   7  O6  ? ? ? 1_555 B C   2 N4    ? ? E G   6   F C   1   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
metalc ? ? 
hydrog ? ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 THR 55 C . ? THR 191 A PRO 56 C ? PRO 192 A 1 2.84   
2 THR 55 D . ? THR 191 B PRO 56 D ? PRO 192 B 1 -10.34 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
A ? 2 ? 
B ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
A 1 2 ? anti-parallel 
B 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
A 1 LEU C 49 ? GLU C 52 ? LEU A 185 GLU A 188 
A 2 LEU C 58 ? ILE C 61 ? LEU A 194 ILE A 197 
B 1 LEU D 49 ? LYS D 51 ? LEU B 185 LYS B 187 
B 2 TRP D 59 ? ILE D 61 ? TRP B 195 ILE B 197 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
A 1 2 N GLU C 52 ? N GLU A 188 O LEU C 58 ? O LEU A 194 
B 1 2 N GLN D 50 ? N GLN B 186 O LYS D 60 ? O LYS B 196 
# 
loop_
_struct_site.id 
_struct_site.pdbx_evidence_code 
_struct_site.pdbx_auth_asym_id 
_struct_site.pdbx_auth_comp_id 
_struct_site.pdbx_auth_seq_id 
_struct_site.pdbx_auth_ins_code 
_struct_site.pdbx_num_residues 
_struct_site.details 
AC1 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NA B 203' 
AC2 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NA E 162' 
AC3 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NA F 163' 
# 
loop_
_struct_site_gen.id 
_struct_site_gen.site_id 
_struct_site_gen.pdbx_num_res 
_struct_site_gen.label_comp_id 
_struct_site_gen.label_asym_id 
_struct_site_gen.label_seq_id 
_struct_site_gen.pdbx_auth_ins_code 
_struct_site_gen.auth_comp_id 
_struct_site_gen.auth_asym_id 
_struct_site_gen.auth_seq_id 
_struct_site_gen.label_atom_id 
_struct_site_gen.label_alt_id 
_struct_site_gen.symmetry 
_struct_site_gen.details 
1  AC1 4 ASN D 37 ? ASN B 173 . ? 1_555 ? 
2  AC1 4 TRP D 59 ? TRP B 195 . ? 1_555 ? 
3  AC1 4 HOH K .  ? HOH B 211 . ? 1_555 ? 
4  AC1 4 C   B 4  ? C   F 3   . ? 1_555 ? 
5  AC2 3 C   A 6  ? C   E 5   . ? 1_555 ? 
6  AC2 3 HOH H .  ? HOH E 61  . ? 1_555 ? 
7  AC2 3 C   B 4  ? C   F 3   . ? 1_555 ? 
8  AC3 3 C   A 4  ? C   E 3   . ? 1_555 ? 
9  AC3 3 C   B 6  ? C   F 5   . ? 1_555 ? 
10 AC3 3 HOH I .  ? HOH F 189 . ? 1_555 ? 
# 
_atom_sites.entry_id                    2GXB 
_atom_sites.fract_transf_matrix[1][1]   0.013586 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010779 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019909 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
N  
NA 
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    P  P     . DU  A 1 1  ? 38.132 4.559   31.727 1.00 58.52 ? 0   DU  E P     1 
ATOM   2    O  OP1   . DU  A 1 1  ? 38.129 5.214   33.061 1.00 57.95 ? 0   DU  E OP1   1 
ATOM   3    O  OP2   . DU  A 1 1  ? 39.406 4.184   31.059 1.00 58.50 ? 0   DU  E OP2   1 
ATOM   4    O  "O5'" . DU  A 1 1  ? 37.167 3.282   31.775 1.00 53.85 ? 0   DU  E "O5'" 1 
ATOM   5    C  "C5'" . DU  A 1 1  ? 37.564 1.946   31.380 1.00 50.41 ? 0   DU  E "C5'" 1 
ATOM   6    C  "C4'" . DU  A 1 1  ? 37.274 1.016   32.548 1.00 46.14 ? 0   DU  E "C4'" 1 
ATOM   7    O  "O4'" . DU  A 1 1  ? 36.249 0.026   32.312 1.00 43.68 ? 0   DU  E "O4'" 1 
ATOM   8    C  "C3'" . DU  A 1 1  ? 38.422 0.148   33.033 1.00 41.99 ? 0   DU  E "C3'" 1 
ATOM   9    O  "O3'" . DU  A 1 1  ? 39.051 0.922   33.998 1.00 36.49 ? 0   DU  E "O3'" 1 
ATOM   10   C  "C2'" . DU  A 1 1  ? 37.755 -1.101  33.615 1.00 41.86 ? 0   DU  E "C2'" 1 
ATOM   11   C  "C1'" . DU  A 1 1  ? 36.300 -0.657  33.544 1.00 42.06 ? 0   DU  E "C1'" 1 
ATOM   12   N  N1    . DU  A 1 1  ? 35.257 -1.707  33.614 1.00 41.54 ? 0   DU  E N1    1 
ATOM   13   C  C2    . DU  A 1 1  ? 34.530 -1.798  34.786 1.00 40.77 ? 0   DU  E C2    1 
ATOM   14   O  O2    . DU  A 1 1  ? 34.720 -1.074  35.750 1.00 38.15 ? 0   DU  E O2    1 
ATOM   15   N  N3    . DU  A 1 1  ? 33.574 -2.786  34.795 1.00 41.99 ? 0   DU  E N3    1 
ATOM   16   C  C4    . DU  A 1 1  ? 33.273 -3.659  33.765 1.00 42.16 ? 0   DU  E C4    1 
ATOM   17   O  O4    . DU  A 1 1  ? 32.380 -4.486  33.936 1.00 42.80 ? 0   DU  E O4    1 
ATOM   18   C  C5    . DU  A 1 1  ? 34.070 -3.500  32.567 1.00 40.99 ? 0   DU  E C5    1 
ATOM   19   C  C6    . DU  A 1 1  ? 35.013 -2.545  32.536 1.00 41.34 ? 0   DU  E C6    1 
ATOM   20   P  P     . C   A 1 2  ? 40.396 1.673   33.656 1.00 32.63 ? 1   C   E P     1 
ATOM   21   O  OP1   . C   A 1 2  ? 40.400 2.936   34.428 1.00 35.14 ? 1   C   E OP1   1 
ATOM   22   O  OP2   . C   A 1 2  ? 40.717 1.674   32.212 1.00 33.33 ? 1   C   E OP2   1 
ATOM   23   O  "O5'" . C   A 1 2  ? 41.345 0.585   34.321 1.00 28.02 ? 1   C   E "O5'" 1 
ATOM   24   C  "C5'" . C   A 1 2  ? 42.738 0.713   34.333 1.00 24.52 ? 1   C   E "C5'" 1 
ATOM   25   C  "C4'" . C   A 1 2  ? 43.210 0.046   35.602 1.00 23.50 ? 1   C   E "C4'" 1 
ATOM   26   O  "O4'" . C   A 1 2  ? 42.806 0.883   36.709 1.00 21.72 ? 1   C   E "O4'" 1 
ATOM   27   C  "C3'" . C   A 1 2  ? 42.624 -1.334  35.879 1.00 22.67 ? 1   C   E "C3'" 1 
ATOM   28   O  "O3'" . C   A 1 2  ? 43.640 -2.211  36.334 1.00 20.43 ? 1   C   E "O3'" 1 
ATOM   29   C  "C2'" . C   A 1 2  ? 41.589 -1.070  36.966 1.00 22.63 ? 1   C   E "C2'" 1 
ATOM   30   O  "O2'" . C   A 1 2  ? 41.396 -2.185  37.811 1.00 22.28 ? 1   C   E "O2'" 1 
ATOM   31   C  "C1'" . C   A 1 2  ? 42.229 0.091   37.719 1.00 20.95 ? 1   C   E "C1'" 1 
ATOM   32   N  N1    . C   A 1 2  ? 41.288 0.954   38.525 1.00 21.07 ? 1   C   E N1    1 
ATOM   33   C  C2    . C   A 1 2  ? 41.264 0.872   39.932 1.00 19.53 ? 1   C   E C2    1 
ATOM   34   O  O2    . C   A 1 2  ? 42.005 0.092   40.536 1.00 19.20 ? 1   C   E O2    1 
ATOM   35   N  N3    . C   A 1 2  ? 40.408 1.662   40.618 1.00 18.78 ? 1   C   E N3    1 
ATOM   36   C  C4    . C   A 1 2  ? 39.597 2.509   39.988 1.00 17.83 ? 1   C   E C4    1 
ATOM   37   N  N4    . C   A 1 2  ? 38.784 3.256   40.740 1.00 15.01 ? 1   C   E N4    1 
ATOM   38   C  C5    . C   A 1 2  ? 39.606 2.615   38.564 1.00 19.17 ? 1   C   E C5    1 
ATOM   39   C  C6    . C   A 1 2  ? 40.457 1.831   37.883 1.00 19.30 ? 1   C   E C6    1 
ATOM   40   P  P     . G   A 1 3  ? 44.364 -3.283  35.388 1.00 19.77 ? 2   G   E P     1 
ATOM   41   O  OP1   . G   A 1 3  ? 43.378 -3.953  34.521 1.00 18.93 ? 2   G   E OP1   1 
ATOM   42   O  OP2   . G   A 1 3  ? 45.213 -4.077  36.315 1.00 18.20 ? 2   G   E OP2   1 
ATOM   43   O  "O5'" . G   A 1 3  ? 45.348 -2.397  34.494 1.00 18.26 ? 2   G   E "O5'" 1 
ATOM   44   C  "C5'" . G   A 1 3  ? 46.487 -1.803  35.104 1.00 16.15 ? 2   G   E "C5'" 1 
ATOM   45   C  "C4'" . G   A 1 3  ? 47.135 -0.777  34.203 1.00 16.12 ? 2   G   E "C4'" 1 
ATOM   46   O  "O4'" . G   A 1 3  ? 46.130 0.154   33.739 1.00 17.79 ? 2   G   E "O4'" 1 
ATOM   47   C  "C3'" . G   A 1 3  ? 48.203 0.086   34.871 1.00 16.16 ? 2   G   E "C3'" 1 
ATOM   48   O  "O3'" . G   A 1 3  ? 49.473 -0.528  34.824 1.00 13.23 ? 2   G   E "O3'" 1 
ATOM   49   C  "C2'" . G   A 1 3  ? 48.168 1.362   34.028 1.00 15.81 ? 2   G   E "C2'" 1 
ATOM   50   O  "O2'" . G   A 1 3  ? 49.065 1.297   32.938 1.00 12.31 ? 2   G   E "O2'" 1 
ATOM   51   C  "C1'" . G   A 1 3  ? 46.720 1.423   33.536 1.00 18.08 ? 2   G   E "C1'" 1 
ATOM   52   N  N9    . G   A 1 3  ? 45.845 2.381   34.204 1.00 20.20 ? 2   G   E N9    1 
ATOM   53   C  C8    . G   A 1 3  ? 45.185 3.427   33.588 1.00 20.90 ? 2   G   E C8    1 
ATOM   54   N  N7    . G   A 1 3  ? 44.455 4.134   34.402 1.00 20.85 ? 2   G   E N7    1 
ATOM   55   C  C5    . G   A 1 3  ? 44.624 3.522   35.636 1.00 20.27 ? 2   G   E C5    1 
ATOM   56   C  C6    . G   A 1 3  ? 44.065 3.854   36.900 1.00 20.24 ? 2   G   E C6    1 
ATOM   57   O  O6    . G   A 1 3  ? 43.288 4.780   37.177 1.00 20.09 ? 2   G   E O6    1 
ATOM   58   N  N1    . G   A 1 3  ? 44.493 2.982   37.904 1.00 18.24 ? 2   G   E N1    1 
ATOM   59   C  C2    . G   A 1 3  ? 45.353 1.928   37.704 1.00 18.19 ? 2   G   E C2    1 
ATOM   60   N  N2    . G   A 1 3  ? 45.640 1.216   38.796 1.00 19.17 ? 2   G   E N2    1 
ATOM   61   N  N3    . G   A 1 3  ? 45.888 1.601   36.528 1.00 18.79 ? 2   G   E N3    1 
ATOM   62   C  C4    . G   A 1 3  ? 45.483 2.438   35.536 1.00 20.02 ? 2   G   E C4    1 
ATOM   63   P  P     . C   A 1 4  ? 50.204 -1.112  36.112 1.00 16.27 ? 3   C   E P     1 
ATOM   64   O  OP1   . C   A 1 4  ? 51.444 -1.786  35.651 1.00 17.24 ? 3   C   E OP1   1 
ATOM   65   O  OP2   . C   A 1 4  ? 49.196 -1.864  36.896 1.00 15.31 ? 3   C   E OP2   1 
ATOM   66   O  "O5'" . C   A 1 4  ? 50.602 0.235   36.899 1.00 15.20 ? 3   C   E "O5'" 1 
ATOM   67   C  "C5'" . C   A 1 4  ? 51.772 0.358   37.677 1.00 14.34 ? 3   C   E "C5'" 1 
ATOM   68   C  "C4'" . C   A 1 4  ? 51.436 0.800   39.093 1.00 16.42 ? 3   C   E "C4'" 1 
ATOM   69   O  "O4'" . C   A 1 4  ? 50.859 2.128   39.088 1.00 16.71 ? 3   C   E "O4'" 1 
ATOM   70   C  "C3'" . C   A 1 4  ? 50.413 -0.029  39.857 1.00 15.84 ? 3   C   E "C3'" 1 
ATOM   71   O  "O3'" . C   A 1 4  ? 50.744 0.003   41.234 1.00 17.94 ? 3   C   E "O3'" 1 
ATOM   72   C  "C2'" . C   A 1 4  ? 49.119 0.727   39.601 1.00 15.82 ? 3   C   E "C2'" 1 
ATOM   73   O  "O2'" . C   A 1 4  ? 48.073 0.428   40.514 1.00 13.39 ? 3   C   E "O2'" 1 
ATOM   74   C  "C1'" . C   A 1 4  ? 49.617 2.149   39.758 1.00 14.39 ? 3   C   E "C1'" 1 
ATOM   75   N  N1    . C   A 1 4  ? 48.752 3.198   39.131 1.00 15.65 ? 3   C   E N1    1 
ATOM   76   C  C2    . C   A 1 4  ? 47.899 4.000   39.912 1.00 15.92 ? 3   C   E C2    1 
ATOM   77   O  O2    . C   A 1 4  ? 47.837 3.854   41.149 1.00 15.14 ? 3   C   E O2    1 
ATOM   78   N  N3    . C   A 1 4  ? 47.144 4.938   39.287 1.00 14.40 ? 3   C   E N3    1 
ATOM   79   C  C4    . C   A 1 4  ? 47.209 5.113   37.974 1.00 15.78 ? 3   C   E C4    1 
ATOM   80   N  N4    . C   A 1 4  ? 46.432 6.055   37.440 1.00 13.62 ? 3   C   E N4    1 
ATOM   81   C  C5    . C   A 1 4  ? 48.063 4.314   37.162 1.00 15.88 ? 3   C   E C5    1 
ATOM   82   C  C6    . C   A 1 4  ? 48.811 3.385   37.775 1.00 15.55 ? 3   C   E C6    1 
ATOM   83   P  P     . G   A 1 5  ? 51.532 -1.141  42.008 1.00 15.57 ? 4   G   E P     1 
ATOM   84   O  OP1   . G   A 1 5  ? 51.112 -2.487  41.540 1.00 14.03 ? 4   G   E OP1   1 
ATOM   85   O  OP2   . G   A 1 5  ? 51.339 -0.772  43.427 1.00 17.19 ? 4   G   E OP2   1 
ATOM   86   O  "O5'" . G   A 1 5  ? 53.052 -0.916  41.591 1.00 16.70 ? 4   G   E "O5'" 1 
ATOM   87   C  "C5'" . G   A 1 5  ? 53.734 0.281   41.942 1.00 17.34 ? 4   G   E "C5'" 1 
ATOM   88   C  "C4'" . G   A 1 5  ? 55.057 0.327   41.218 1.00 17.19 ? 4   G   E "C4'" 1 
ATOM   89   O  "O4'" . G   A 1 5  ? 54.828 0.333   39.786 1.00 16.33 ? 4   G   E "O4'" 1 
ATOM   90   C  "C3'" . G   A 1 5  ? 55.887 1.562   41.532 1.00 18.56 ? 4   G   E "C3'" 1 
ATOM   91   O  "O3'" . G   A 1 5  ? 56.875 1.239   42.484 1.00 20.20 ? 4   G   E "O3'" 1 
ATOM   92   C  "C2'" . G   A 1 5  ? 56.589 1.876   40.227 1.00 17.19 ? 4   G   E "C2'" 1 
ATOM   93   O  "O2'" . G   A 1 5  ? 57.872 1.275   40.245 1.00 16.37 ? 4   G   E "O2'" 1 
ATOM   94   C  "C1'" . G   A 1 5  ? 55.712 1.248   39.149 1.00 16.27 ? 4   G   E "C1'" 1 
ATOM   95   N  N9    . G   A 1 5  ? 54.934 2.203   38.354 1.00 15.57 ? 4   G   E N9    1 
ATOM   96   C  C8    . G   A 1 5  ? 55.009 2.358   36.989 1.00 16.57 ? 4   G   E C8    1 
ATOM   97   N  N7    . G   A 1 5  ? 54.207 3.266   36.511 1.00 16.76 ? 4   G   E N7    1 
ATOM   98   C  C5    . G   A 1 5  ? 53.548 3.751   37.635 1.00 15.66 ? 4   G   E C5    1 
ATOM   99   C  C6    . G   A 1 5  ? 52.554 4.758   37.749 1.00 14.66 ? 4   G   E C6    1 
ATOM   100  O  O6    . G   A 1 5  ? 52.026 5.446   36.863 1.00 13.45 ? 4   G   E O6    1 
ATOM   101  N  N1    . G   A 1 5  ? 52.159 4.941   39.069 1.00 14.71 ? 4   G   E N1    1 
ATOM   102  C  C2    . G   A 1 5  ? 52.647 4.251   40.145 1.00 14.44 ? 4   G   E C2    1 
ATOM   103  N  N2    . G   A 1 5  ? 52.125 4.580   41.325 1.00 15.20 ? 4   G   E N2    1 
ATOM   104  N  N3    . G   A 1 5  ? 53.574 3.305   40.058 1.00 18.03 ? 4   G   E N3    1 
ATOM   105  C  C4    . G   A 1 5  ? 53.986 3.106   38.778 1.00 16.81 ? 4   G   E C4    1 
ATOM   106  P  P     . C   A 1 6  ? 57.043 2.036   43.842 1.00 25.26 ? 5   C   E P     1 
ATOM   107  O  OP1   . C   A 1 6  ? 58.373 1.682   44.383 1.00 23.32 ? 5   C   E OP1   1 
ATOM   108  O  OP2   . C   A 1 6  ? 55.830 1.751   44.631 1.00 28.64 ? 5   C   E OP2   1 
ATOM   109  O  "O5'" . C   A 1 6  ? 57.019 3.592   43.502 1.00 22.77 ? 5   C   E "O5'" 1 
ATOM   110  C  "C5'" . C   A 1 6  ? 57.489 4.453   44.540 1.00 23.25 ? 5   C   E "C5'" 1 
ATOM   111  C  "C4'" . C   A 1 6  ? 56.577 5.633   44.762 1.00 21.28 ? 5   C   E "C4'" 1 
ATOM   112  O  "O4'" . C   A 1 6  ? 56.490 6.373   43.522 1.00 21.70 ? 5   C   E "O4'" 1 
ATOM   113  C  "C3'" . C   A 1 6  ? 55.155 5.285   45.157 1.00 21.44 ? 5   C   E "C3'" 1 
ATOM   114  O  "O3'" . C   A 1 6  ? 54.643 6.217   46.096 1.00 28.60 ? 5   C   E "O3'" 1 
ATOM   115  C  "C2'" . C   A 1 6  ? 54.407 5.403   43.844 1.00 20.82 ? 5   C   E "C2'" 1 
ATOM   116  O  "O2'" . C   A 1 6  ? 53.034 5.666   44.040 1.00 19.06 ? 5   C   E "O2'" 1 
ATOM   117  C  "C1'" . C   A 1 6  ? 55.128 6.583   43.204 1.00 19.32 ? 5   C   E "C1'" 1 
ATOM   118  N  N1    . C   A 1 6  ? 55.028 6.705   41.708 1.00 19.56 ? 5   C   E N1    1 
ATOM   119  C  C2    . C   A 1 6  ? 54.087 7.565   41.123 1.00 19.54 ? 5   C   E C2    1 
ATOM   120  O  O2    . C   A 1 6  ? 53.321 8.221   41.840 1.00 23.26 ? 5   C   E O2    1 
ATOM   121  N  N3    . C   A 1 6  ? 54.029 7.662   39.777 1.00 18.69 ? 5   C   E N3    1 
ATOM   122  C  C4    . C   A 1 6  ? 54.864 6.952   39.006 1.00 19.60 ? 5   C   E C4    1 
ATOM   123  N  N4    . C   A 1 6  ? 54.767 7.084   37.675 1.00 18.11 ? 5   C   E N4    1 
ATOM   124  C  C5    . C   A 1 6  ? 55.822 6.069   39.580 1.00 17.88 ? 5   C   E C5    1 
ATOM   125  C  C6    . C   A 1 6  ? 55.868 5.972   40.912 1.00 17.51 ? 5   C   E C6    1 
ATOM   126  P  P     . G   A 1 7  ? 54.536 5.911   47.664 1.00 32.09 ? 6   G   E P     1 
ATOM   127  O  OP1   . G   A 1 7  ? 54.169 4.492   47.875 1.00 32.75 ? 6   G   E OP1   1 
ATOM   128  O  OP2   . G   A 1 7  ? 53.680 6.954   48.266 1.00 34.71 ? 6   G   E OP2   1 
ATOM   129  O  "O5'" . G   A 1 7  ? 56.048 6.153   48.130 1.00 32.79 ? 6   G   E "O5'" 1 
ATOM   130  C  "C5'" . G   A 1 7  ? 56.706 7.389   47.932 1.00 32.30 ? 6   G   E "C5'" 1 
ATOM   131  C  "C4'" . G   A 1 7  ? 58.168 7.277   48.341 1.00 32.86 ? 6   G   E "C4'" 1 
ATOM   132  O  "O4'" . G   A 1 7  ? 58.864 6.354   47.467 1.00 32.50 ? 6   G   E "O4'" 1 
ATOM   133  C  "C3'" . G   A 1 7  ? 58.922 8.601   48.274 1.00 34.10 ? 6   G   E "C3'" 1 
ATOM   134  O  "O3'" . G   A 1 7  ? 58.970 9.212   49.579 1.00 34.83 ? 6   G   E "O3'" 1 
ATOM   135  C  "C2'" . G   A 1 7  ? 60.303 8.240   47.722 1.00 33.55 ? 6   G   E "C2'" 1 
ATOM   136  O  "O2'" . G   A 1 7  ? 61.283 8.192   48.739 1.00 35.46 ? 6   G   E "O2'" 1 
ATOM   137  C  "C1'" . G   A 1 7  ? 60.130 6.864   47.074 1.00 31.91 ? 6   G   E "C1'" 1 
ATOM   138  N  N9    . G   A 1 7  ? 60.172 6.816   45.608 1.00 30.26 ? 6   G   E N9    1 
ATOM   139  C  C8    . G   A 1 7  ? 60.985 6.007   44.850 1.00 30.78 ? 6   G   E C8    1 
ATOM   140  N  N7    . G   A 1 7  ? 60.820 6.134   43.563 1.00 29.23 ? 6   G   E N7    1 
ATOM   141  C  C5    . G   A 1 7  ? 59.826 7.094   43.450 1.00 29.66 ? 6   G   E C5    1 
ATOM   142  C  C6    . G   A 1 7  ? 59.221 7.644   42.288 1.00 30.60 ? 6   G   E C6    1 
ATOM   143  O  O6    . G   A 1 7  ? 59.452 7.384   41.097 1.00 30.26 ? 6   G   E O6    1 
ATOM   144  N  N1    . G   A 1 7  ? 58.248 8.596   42.598 1.00 30.63 ? 6   G   E N1    1 
ATOM   145  C  C2    . G   A 1 7  ? 57.904 8.965   43.877 1.00 31.39 ? 6   G   E C2    1 
ATOM   146  N  N2    . G   A 1 7  ? 56.937 9.891   43.957 1.00 30.97 ? 6   G   E N2    1 
ATOM   147  N  N3    . G   A 1 7  ? 58.459 8.453   44.984 1.00 30.24 ? 6   G   E N3    1 
ATOM   148  C  C4    . G   A 1 7  ? 59.413 7.525   44.698 1.00 30.17 ? 6   G   E C4    1 
ATOM   149  P  P     . C   B 1 2  ? 54.797 14.784  35.321 1.00 32.14 ? 1   C   F P     1 
ATOM   150  O  OP1   . C   B 1 2  ? 54.367 16.191  35.211 1.00 31.81 ? 1   C   F OP1   1 
ATOM   151  O  OP2   . C   B 1 2  ? 54.332 13.774  34.338 1.00 29.76 ? 1   C   F OP2   1 
ATOM   152  O  "O5'" . C   B 1 2  ? 54.325 14.265  36.754 1.00 29.40 ? 1   C   F "O5'" 1 
ATOM   153  C  "C5'" . C   B 1 2  ? 52.995 14.391  37.211 1.00 24.37 ? 1   C   F "C5'" 1 
ATOM   154  C  "C4'" . C   B 1 2  ? 52.961 13.981  38.674 1.00 23.16 ? 1   C   F "C4'" 1 
ATOM   155  O  "O4'" . C   B 1 2  ? 53.465 12.629  38.786 1.00 20.42 ? 1   C   F "O4'" 1 
ATOM   156  C  "C3'" . C   B 1 2  ? 53.828 14.838  39.593 1.00 21.17 ? 1   C   F "C3'" 1 
ATOM   157  O  "O3'" . C   B 1 2  ? 53.221 15.022  40.873 1.00 19.14 ? 1   C   F "O3'" 1 
ATOM   158  C  "C2'" . C   B 1 2  ? 55.105 14.020  39.694 1.00 21.43 ? 1   C   F "C2'" 1 
ATOM   159  O  "O2'" . C   B 1 2  ? 55.846 14.342  40.855 1.00 23.25 ? 1   C   F "O2'" 1 
ATOM   160  C  "C1'" . C   B 1 2  ? 54.502 12.620  39.736 1.00 20.47 ? 1   C   F "C1'" 1 
ATOM   161  N  N1    . C   B 1 2  ? 55.438 11.521  39.393 1.00 19.84 ? 1   C   F N1    1 
ATOM   162  C  C2    . C   B 1 2  ? 55.950 10.723  40.417 1.00 20.17 ? 1   C   F C2    1 
ATOM   163  O  O2    . C   B 1 2  ? 55.629 10.945  41.591 1.00 22.02 ? 1   C   F O2    1 
ATOM   164  N  N3    . C   B 1 2  ? 56.806 9.727   40.101 1.00 19.80 ? 1   C   F N3    1 
ATOM   165  C  C4    . C   B 1 2  ? 57.147 9.499   38.839 1.00 21.28 ? 1   C   F C4    1 
ATOM   166  N  N4    . C   B 1 2  ? 57.994 8.490   38.614 1.00 22.47 ? 1   C   F N4    1 
ATOM   167  C  C5    . C   B 1 2  ? 56.632 10.296  37.770 1.00 21.51 ? 1   C   F C5    1 
ATOM   168  C  C6    . C   B 1 2  ? 55.785 11.285  38.090 1.00 20.20 ? 1   C   F C6    1 
ATOM   169  P  P     . G   B 1 3  ? 52.262 16.277  41.192 1.00 17.46 ? 2   G   F P     1 
ATOM   170  O  OP1   . G   B 1 3  ? 52.828 17.492  40.578 1.00 21.32 ? 2   G   F OP1   1 
ATOM   171  O  OP2   . G   B 1 3  ? 52.014 16.260  42.654 1.00 18.88 ? 2   G   F OP2   1 
ATOM   172  O  "O5'" . G   B 1 3  ? 50.943 15.902  40.366 1.00 15.90 ? 2   G   F "O5'" 1 
ATOM   173  C  "C5'" . G   B 1 3  ? 50.073 14.863  40.809 1.00 16.20 ? 2   G   F "C5'" 1 
ATOM   174  C  "C4'" . G   B 1 3  ? 49.034 14.559  39.748 1.00 15.88 ? 2   G   F "C4'" 1 
ATOM   175  O  "O4'" . G   B 1 3  ? 49.718 14.293  38.506 1.00 16.92 ? 2   G   F "O4'" 1 
ATOM   176  C  "C3'" . G   B 1 3  ? 48.157 13.334  39.985 1.00 16.21 ? 2   G   F "C3'" 1 
ATOM   177  O  "O3'" . G   B 1 3  ? 46.998 13.641  40.793 1.00 16.18 ? 2   G   F "O3'" 1 
ATOM   178  C  "C2'" . G   B 1 3  ? 47.772 12.935  38.565 1.00 15.66 ? 2   G   F "C2'" 1 
ATOM   179  O  "O2'" . G   B 1 3  ? 46.569 13.532  38.134 1.00 16.01 ? 2   G   F "O2'" 1 
ATOM   180  C  "C1'" . G   B 1 3  ? 48.921 13.451  37.704 1.00 17.38 ? 2   G   F "C1'" 1 
ATOM   181  N  N9    . G   B 1 3  ? 49.794 12.413  37.178 1.00 17.66 ? 2   G   F N9    1 
ATOM   182  C  C8    . G   B 1 3  ? 49.990 12.108  35.860 1.00 17.59 ? 2   G   F C8    1 
ATOM   183  N  N7    . G   B 1 3  ? 50.837 11.151  35.681 1.00 19.22 ? 2   G   F N7    1 
ATOM   184  C  C5    . G   B 1 3  ? 51.219 10.786  36.965 1.00 19.32 ? 2   G   F C5    1 
ATOM   185  C  C6    . G   B 1 3  ? 52.116 9.785   37.399 1.00 18.69 ? 2   G   F C6    1 
ATOM   186  O  O6    . G   B 1 3  ? 52.780 8.997   36.713 1.00 18.58 ? 2   G   F O6    1 
ATOM   187  N  N1    . G   B 1 3  ? 52.216 9.748   38.787 1.00 18.37 ? 2   G   F N1    1 
ATOM   188  C  C2    . G   B 1 3  ? 51.537 10.564  39.658 1.00 17.20 ? 2   G   F C2    1 
ATOM   189  N  N2    . G   B 1 3  ? 51.777 10.365  40.963 1.00 17.15 ? 2   G   F N2    1 
ATOM   190  N  N3    . G   B 1 3  ? 50.695 11.510  39.266 1.00 18.01 ? 2   G   F N3    1 
ATOM   191  C  C4    . G   B 1 3  ? 50.583 11.555  37.907 1.00 19.39 ? 2   G   F C4    1 
ATOM   192  P  P     . C   B 1 4  ? 46.841 13.103  42.303 1.00 15.58 ? 3   C   F P     1 
ATOM   193  O  OP1   . C   B 1 4  ? 45.603 13.720  42.850 1.00 11.79 ? 3   C   F OP1   1 
ATOM   194  O  OP2   . C   B 1 4  ? 48.142 13.285  42.984 1.00 11.01 ? 3   C   F OP2   1 
ATOM   195  O  "O5'" . C   B 1 4  ? 46.587 11.532  42.103 1.00 13.47 ? 3   C   F "O5'" 1 
ATOM   196  C  "C5'" . C   B 1 4  ? 45.790 10.788  43.019 1.00 12.50 ? 3   C   F "C5'" 1 
ATOM   197  C  "C4'" . C   B 1 4  ? 46.535 9.583   43.561 1.00 11.55 ? 3   C   F "C4'" 1 
ATOM   198  O  "O4'" . C   B 1 4  ? 46.844 8.707   42.456 1.00 11.94 ? 3   C   F "O4'" 1 
ATOM   199  C  "C3'" . C   B 1 4  ? 47.867 9.874   44.239 1.00 14.02 ? 3   C   F "C3'" 1 
ATOM   200  O  "O3'" . C   B 1 4  ? 48.148 8.951   45.291 1.00 12.11 ? 3   C   F "O3'" 1 
ATOM   201  C  "C2'" . C   B 1 4  ? 48.844 9.696   43.085 1.00 13.87 ? 3   C   F "C2'" 1 
ATOM   202  O  "O2'" . C   B 1 4  ? 50.175 9.488   43.507 1.00 15.64 ? 3   C   F "O2'" 1 
ATOM   203  C  "C1'" . C   B 1 4  ? 48.235 8.463   42.439 1.00 13.40 ? 3   C   F "C1'" 1 
ATOM   204  N  N1    . C   B 1 4  ? 48.666 8.205   41.038 1.00 13.62 ? 3   C   F N1    1 
ATOM   205  C  C2    . C   B 1 4  ? 49.633 7.216   40.773 1.00 13.47 ? 3   C   F C2    1 
ATOM   206  O  O2    . C   B 1 4  ? 50.150 6.578   41.705 1.00 12.18 ? 3   C   F O2    1 
ATOM   207  N  N3    . C   B 1 4  ? 49.996 6.992   39.488 1.00 12.78 ? 3   C   F N3    1 
ATOM   208  C  C4    . C   B 1 4  ? 49.466 7.695   38.494 1.00 12.02 ? 3   C   F C4    1 
ATOM   209  N  N4    . C   B 1 4  ? 49.886 7.413   37.259 1.00 13.67 ? 3   C   F N4    1 
ATOM   210  C  C5    . C   B 1 4  ? 48.480 8.701   38.735 1.00 13.34 ? 3   C   F C5    1 
ATOM   211  C  C6    . C   B 1 4  ? 48.116 8.926   40.012 1.00 13.40 ? 3   C   F C6    1 
ATOM   212  P  P     . G   B 1 5  ? 47.844 9.309   46.821 1.00 14.45 ? 4   G   F P     1 
ATOM   213  O  OP1   . G   B 1 5  ? 48.149 10.730  47.056 1.00 10.12 ? 4   G   F OP1   1 
ATOM   214  O  OP2   . G   B 1 5  ? 48.518 8.273   47.634 1.00 16.70 ? 4   G   F OP2   1 
ATOM   215  O  "O5'" . G   B 1 5  ? 46.262 9.075   46.994 1.00 13.53 ? 4   G   F "O5'" 1 
ATOM   216  C  "C5'" . G   B 1 5  ? 45.627 7.840   46.690 1.00 14.74 ? 4   G   F "C5'" 1 
ATOM   217  C  "C4'" . G   B 1 5  ? 44.124 8.041   46.589 1.00 15.78 ? 4   G   F "C4'" 1 
ATOM   218  O  "O4'" . G   B 1 5  ? 43.835 8.967   45.514 1.00 16.83 ? 4   G   F "O4'" 1 
ATOM   219  C  "C3'" . G   B 1 5  ? 43.313 6.789   46.302 1.00 17.34 ? 4   G   F "C3'" 1 
ATOM   220  O  "O3'" . G   B 1 5  ? 42.878 6.162   47.517 1.00 20.81 ? 4   G   F "O3'" 1 
ATOM   221  C  "C2'" . G   B 1 5  ? 42.112 7.322   45.525 1.00 16.61 ? 4   G   F "C2'" 1 
ATOM   222  O  "O2'" . G   B 1 5  ? 41.010 7.588   46.383 1.00 15.07 ? 4   G   F "O2'" 1 
ATOM   223  C  "C1'" . G   B 1 5  ? 42.621 8.614   44.885 1.00 17.05 ? 4   G   F "C1'" 1 
ATOM   224  N  N9    . G   B 1 5  ? 42.898 8.534   43.457 1.00 16.13 ? 4   G   F N9    1 
ATOM   225  C  C8    . G   B 1 5  ? 42.310 9.296   42.477 1.00 16.35 ? 4   G   F C8    1 
ATOM   226  N  N7    . G   B 1 5  ? 42.744 9.041   41.275 1.00 15.55 ? 4   G   F N7    1 
ATOM   227  C  C5    . G   B 1 5  ? 43.688 8.043   41.469 1.00 17.33 ? 4   G   F C5    1 
ATOM   228  C  C6    . G   B 1 5  ? 44.500 7.368   40.529 1.00 17.37 ? 4   G   F C6    1 
ATOM   229  O  O6    . G   B 1 5  ? 44.530 7.523   39.308 1.00 18.20 ? 4   G   F O6    1 
ATOM   230  N  N1    . G   B 1 5  ? 45.323 6.416   41.122 1.00 16.10 ? 4   G   F N1    1 
ATOM   231  C  C2    . G   B 1 5  ? 45.370 6.153   42.470 1.00 16.94 ? 4   G   F C2    1 
ATOM   232  N  N2    . G   B 1 5  ? 46.242 5.206   42.859 1.00 16.48 ? 4   G   F N2    1 
ATOM   233  N  N3    . G   B 1 5  ? 44.624 6.790   43.369 1.00 16.36 ? 4   G   F N3    1 
ATOM   234  C  C4    . G   B 1 5  ? 43.805 7.718   42.808 1.00 16.76 ? 4   G   F C4    1 
ATOM   235  P  P     . C   B 1 6  ? 43.366 4.722   47.978 1.00 23.78 ? 5   C   F P     1 
ATOM   236  O  OP1   . C   B 1 6  ? 42.754 4.445   49.303 1.00 23.75 ? 5   C   F OP1   1 
ATOM   237  O  OP2   . C   B 1 6  ? 44.843 4.654   47.838 1.00 26.36 ? 5   C   F OP2   1 
ATOM   238  O  "O5'" . C   B 1 6  ? 42.725 3.767   46.883 1.00 19.56 ? 5   C   F "O5'" 1 
ATOM   239  C  "C5'" . C   B 1 6  ? 42.564 2.399   47.227 1.00 18.28 ? 5   C   F "C5'" 1 
ATOM   240  C  "C4'" . C   B 1 6  ? 43.119 1.488   46.152 1.00 17.77 ? 5   C   F "C4'" 1 
ATOM   241  O  "O4'" . C   B 1 6  ? 42.610 1.877   44.855 1.00 16.72 ? 5   C   F "O4'" 1 
ATOM   242  C  "C3'" . C   B 1 6  ? 44.631 1.499   46.011 1.00 18.16 ? 5   C   F "C3'" 1 
ATOM   243  O  "O3'" . C   B 1 6  ? 45.092 0.188   45.646 1.00 20.88 ? 5   C   F "O3'" 1 
ATOM   244  C  "C2'" . C   B 1 6  ? 44.821 2.504   44.889 1.00 16.65 ? 5   C   F "C2'" 1 
ATOM   245  O  "O2'" . C   B 1 6  ? 46.107 2.420   44.309 1.00 14.34 ? 5   C   F "O2'" 1 
ATOM   246  C  "C1'" . C   B 1 6  ? 43.697 2.031   43.971 1.00 16.61 ? 5   C   F "C1'" 1 
ATOM   247  N  N1    . C   B 1 6  ? 43.291 2.923   42.826 1.00 16.75 ? 5   C   F N1    1 
ATOM   248  C  C2    . C   B 1 6  ? 43.874 2.734   41.565 1.00 17.09 ? 5   C   F C2    1 
ATOM   249  O  O2    . C   B 1 6  ? 44.733 1.852   41.404 1.00 15.09 ? 5   C   F O2    1 
ATOM   250  N  N3    . C   B 1 6  ? 43.496 3.548   40.545 1.00 17.39 ? 5   C   F N3    1 
ATOM   251  C  C4    . C   B 1 6  ? 42.572 4.496   40.718 1.00 18.91 ? 5   C   F C4    1 
ATOM   252  N  N4    . C   B 1 6  ? 42.245 5.253   39.660 1.00 17.55 ? 5   C   F N4    1 
ATOM   253  C  C5    . C   B 1 6  ? 41.963 4.704   41.992 1.00 17.63 ? 5   C   F C5    1 
ATOM   254  C  C6    . C   B 1 6  ? 42.343 3.902   43.001 1.00 17.74 ? 5   C   F C6    1 
ATOM   255  P  P     . G   B 1 7  ? 45.589 -0.859  46.751 1.00 23.70 ? 6   G   F P     1 
ATOM   256  O  OP1   . G   B 1 7  ? 46.806 -0.331  47.406 1.00 20.65 ? 6   G   F OP1   1 
ATOM   257  O  OP2   . G   B 1 7  ? 45.612 -2.180  46.061 1.00 21.96 ? 6   G   F OP2   1 
ATOM   258  O  "O5'" . G   B 1 7  ? 44.398 -0.838  47.833 1.00 22.67 ? 6   G   F "O5'" 1 
ATOM   259  C  "C5'" . G   B 1 7  ? 43.352 -1.807  47.729 1.00 21.58 ? 6   G   F "C5'" 1 
ATOM   260  C  "C4'" . G   B 1 7  ? 42.326 -1.662  48.839 1.00 21.61 ? 6   G   F "C4'" 1 
ATOM   261  O  "O4'" . G   B 1 7  ? 41.551 -0.458  48.616 1.00 21.16 ? 6   G   F "O4'" 1 
ATOM   262  C  "C3'" . G   B 1 7  ? 41.293 -2.784  48.883 1.00 20.91 ? 6   G   F "C3'" 1 
ATOM   263  O  "O3'" . G   B 1 7  ? 40.678 -2.879  50.159 1.00 22.60 ? 6   G   F "O3'" 1 
ATOM   264  C  "C2'" . G   B 1 7  ? 40.300 -2.312  47.842 1.00 20.85 ? 6   G   F "C2'" 1 
ATOM   265  O  "O2'" . G   B 1 7  ? 39.035 -2.916  47.970 1.00 21.33 ? 6   G   F "O2'" 1 
ATOM   266  C  "C1'" . G   B 1 7  ? 40.231 -0.839  48.241 1.00 21.64 ? 6   G   F "C1'" 1 
ATOM   267  N  N9    . G   B 1 7  ? 39.749 0.093   47.230 1.00 20.07 ? 6   G   F N9    1 
ATOM   268  C  C8    . G   B 1 7  ? 38.880 1.123   47.496 1.00 22.00 ? 6   G   F C8    1 
ATOM   269  N  N7    . G   B 1 7  ? 38.583 1.840   46.455 1.00 21.72 ? 6   G   F N7    1 
ATOM   270  C  C5    . G   B 1 7  ? 39.305 1.249   45.434 1.00 19.23 ? 6   G   F C5    1 
ATOM   271  C  C6    . G   B 1 7  ? 39.382 1.611   44.080 1.00 18.62 ? 6   G   F C6    1 
ATOM   272  O  O6    . G   B 1 7  ? 38.795 2.542   43.527 1.00 19.27 ? 6   G   F O6    1 
ATOM   273  N  N1    . G   B 1 7  ? 40.216 0.769   43.342 1.00 18.91 ? 6   G   F N1    1 
ATOM   274  C  C2    . G   B 1 7  ? 40.903 -0.296  43.876 1.00 17.89 ? 6   G   F C2    1 
ATOM   275  N  N2    . G   B 1 7  ? 41.661 -0.992  43.021 1.00 19.54 ? 6   G   F N2    1 
ATOM   276  N  N3    . G   B 1 7  ? 40.847 -0.646  45.156 1.00 19.45 ? 6   G   F N3    1 
ATOM   277  C  C4    . G   B 1 7  ? 40.035 0.170   45.885 1.00 19.89 ? 6   G   F C4    1 
ATOM   278  N  N     . SER C 2 1  ? 70.214 -8.493  40.914 1.00 29.09 ? 137 SER A N     1 
ATOM   279  C  CA    . SER C 2 1  ? 69.265 -8.447  42.076 1.00 28.68 ? 137 SER A CA    1 
ATOM   280  C  C     . SER C 2 1  ? 68.557 -9.793  42.285 1.00 28.70 ? 137 SER A C     1 
ATOM   281  O  O     . SER C 2 1  ? 68.203 -10.483 41.333 1.00 28.09 ? 137 SER A O     1 
ATOM   282  C  CB    . SER C 2 1  ? 68.252 -7.303  41.896 1.00 29.01 ? 137 SER A CB    1 
ATOM   283  O  OG    . SER C 2 1  ? 66.991 -7.560  42.497 1.00 28.12 ? 137 SER A OG    1 
ATOM   284  N  N     . HIS C 2 2  ? 68.364 -10.155 43.548 1.00 28.55 ? 138 HIS A N     1 
ATOM   285  C  CA    . HIS C 2 2  ? 67.682 -11.395 43.913 1.00 28.86 ? 138 HIS A CA    1 
ATOM   286  C  C     . HIS C 2 2  ? 66.304 -11.507 43.245 1.00 27.58 ? 138 HIS A C     1 
ATOM   287  O  O     . HIS C 2 2  ? 65.982 -12.532 42.635 1.00 27.42 ? 138 HIS A O     1 
ATOM   288  C  CB    . HIS C 2 2  ? 67.549 -11.475 45.438 1.00 29.27 ? 138 HIS A CB    1 
ATOM   289  C  CG    . HIS C 2 2  ? 66.824 -12.688 45.927 1.00 32.31 ? 138 HIS A CG    1 
ATOM   290  N  ND1   . HIS C 2 2  ? 67.370 -13.955 45.873 1.00 36.99 ? 138 HIS A ND1   1 
ATOM   291  C  CD2   . HIS C 2 2  ? 65.603 -12.829 46.498 1.00 35.19 ? 138 HIS A CD2   1 
ATOM   292  C  CE1   . HIS C 2 2  ? 66.511 -14.824 46.376 1.00 37.90 ? 138 HIS A CE1   1 
ATOM   293  N  NE2   . HIS C 2 2  ? 65.432 -14.167 46.767 1.00 37.05 ? 138 HIS A NE2   1 
ATOM   294  N  N     . MET C 2 3  ? 65.513 -10.441 43.353 1.00 26.18 ? 139 MET A N     1 
ATOM   295  C  CA    . MET C 2 3  ? 64.151 -10.410 42.803 1.00 25.01 ? 139 MET A CA    1 
ATOM   296  C  C     . MET C 2 3  ? 64.144 -10.423 41.275 1.00 23.79 ? 139 MET A C     1 
ATOM   297  O  O     . MET C 2 3  ? 63.326 -11.110 40.665 1.00 22.40 ? 139 MET A O     1 
ATOM   298  C  CB    . MET C 2 3  ? 63.405 -9.175  43.314 1.00 25.18 ? 139 MET A CB    1 
ATOM   299  C  CG    . MET C 2 3  ? 61.915 -9.126  42.958 1.00 26.17 ? 139 MET A CG    1 
ATOM   300  S  SD    . MET C 2 3  ? 61.004 -10.640 43.323 1.00 26.78 ? 139 MET A SD    1 
ATOM   301  C  CE    . MET C 2 3  ? 61.335 -10.848 45.072 1.00 25.74 ? 139 MET A CE    1 
ATOM   302  N  N     . GLU C 2 4  ? 65.046 -9.650  40.673 1.00 22.68 ? 140 GLU A N     1 
ATOM   303  C  CA    . GLU C 2 4  ? 65.199 -9.625  39.220 1.00 22.99 ? 140 GLU A CA    1 
ATOM   304  C  C     . GLU C 2 4  ? 65.398 -11.030 38.675 1.00 22.17 ? 140 GLU A C     1 
ATOM   305  O  O     . GLU C 2 4  ? 64.757 -11.418 37.697 1.00 21.41 ? 140 GLU A O     1 
ATOM   306  C  CB    . GLU C 2 4  ? 66.385 -8.749  38.800 1.00 23.23 ? 140 GLU A CB    1 
ATOM   307  C  CG    . GLU C 2 4  ? 66.121 -7.253  38.899 1.00 25.78 ? 140 GLU A CG    1 
ATOM   308  C  CD    . GLU C 2 4  ? 67.368 -6.418  38.641 1.00 27.77 ? 140 GLU A CD    1 
ATOM   309  O  OE1   . GLU C 2 4  ? 68.241 -6.847  37.862 1.00 30.39 ? 140 GLU A OE1   1 
ATOM   310  O  OE2   . GLU C 2 4  ? 67.477 -5.330  39.234 1.00 32.43 ? 140 GLU A OE2   1 
ATOM   311  N  N     . GLN C 2 5  ? 66.292 -11.779 39.317 1.00 21.90 ? 141 GLN A N     1 
ATOM   312  C  CA    . GLN C 2 5  ? 66.574 -13.158 38.928 1.00 21.96 ? 141 GLN A CA    1 
ATOM   313  C  C     . GLN C 2 5  ? 65.367 -14.075 39.064 1.00 20.67 ? 141 GLN A C     1 
ATOM   314  O  O     . GLN C 2 5  ? 65.121 -14.902 38.185 1.00 21.19 ? 141 GLN A O     1 
ATOM   315  C  CB    . GLN C 2 5  ? 67.755 -13.726 39.716 1.00 22.76 ? 141 GLN A CB    1 
ATOM   316  C  CG    . GLN C 2 5  ? 69.035 -13.763 38.903 1.00 26.65 ? 141 GLN A CG    1 
ATOM   317  C  CD    . GLN C 2 5  ? 69.427 -12.399 38.385 1.00 29.10 ? 141 GLN A CD    1 
ATOM   318  O  OE1   . GLN C 2 5  ? 69.430 -12.150 37.173 1.00 29.23 ? 141 GLN A OE1   1 
ATOM   319  N  NE2   . GLN C 2 5  ? 69.754 -11.499 39.304 1.00 31.70 ? 141 GLN A NE2   1 
ATOM   320  N  N     . ARG C 2 6  ? 64.618 -13.935 40.151 1.00 18.90 ? 142 ARG A N     1 
ATOM   321  C  CA    . ARG C 2 6  ? 63.412 -14.727 40.328 1.00 18.13 ? 142 ARG A CA    1 
ATOM   322  C  C     . ARG C 2 6  ? 62.412 -14.476 39.206 1.00 17.29 ? 142 ARG A C     1 
ATOM   323  O  O     . ARG C 2 6  ? 61.851 -15.418 38.645 1.00 16.35 ? 142 ARG A O     1 
ATOM   324  C  CB    . ARG C 2 6  ? 62.759 -14.422 41.668 1.00 18.13 ? 142 ARG A CB    1 
ATOM   325  C  CG    . ARG C 2 6  ? 63.572 -14.880 42.862 1.00 18.45 ? 142 ARG A CG    1 
ATOM   326  C  CD    . ARG C 2 6  ? 62.765 -14.734 44.121 1.00 19.56 ? 142 ARG A CD    1 
ATOM   327  N  NE    . ARG C 2 6  ? 61.763 -15.787 44.214 1.00 19.96 ? 142 ARG A NE    1 
ATOM   328  C  CZ    . ARG C 2 6  ? 60.640 -15.715 44.921 1.00 21.04 ? 142 ARG A CZ    1 
ATOM   329  N  NH1   . ARG C 2 6  ? 60.330 -14.626 45.613 1.00 21.89 ? 142 ARG A NH1   1 
ATOM   330  N  NH2   . ARG C 2 6  ? 59.816 -16.753 44.921 1.00 22.99 ? 142 ARG A NH2   1 
ATOM   331  N  N     . ILE C 2 7  ? 62.213 -13.204 38.871 1.00 16.87 ? 143 ILE A N     1 
ATOM   332  C  CA    . ILE C 2 7  ? 61.228 -12.814 37.864 1.00 16.91 ? 143 ILE A CA    1 
ATOM   333  C  C     . ILE C 2 7  ? 61.672 -13.313 36.484 1.00 17.26 ? 143 ILE A C     1 
ATOM   334  O  O     . ILE C 2 7  ? 60.894 -13.940 35.755 1.00 17.26 ? 143 ILE A O     1 
ATOM   335  C  CB    . ILE C 2 7  ? 60.986 -11.266 37.880 1.00 17.27 ? 143 ILE A CB    1 
ATOM   336  C  CG1   . ILE C 2 7  ? 60.312 -10.854 39.201 1.00 17.81 ? 143 ILE A CG1   1 
ATOM   337  C  CG2   . ILE C 2 7  ? 60.118 -10.827 36.707 1.00 17.23 ? 143 ILE A CG2   1 
ATOM   338  C  CD1   . ILE C 2 7  ? 60.108 -9.361  39.379 1.00 18.40 ? 143 ILE A CD1   1 
ATOM   339  N  N     . LEU C 2 8  ? 62.931 -13.054 36.143 1.00 17.09 ? 144 LEU A N     1 
ATOM   340  C  CA    . LEU C 2 8  ? 63.473 -13.467 34.853 1.00 17.00 ? 144 LEU A CA    1 
ATOM   341  C  C     . LEU C 2 8  ? 63.414 -14.992 34.698 1.00 16.57 ? 144 LEU A C     1 
ATOM   342  O  O     . LEU C 2 8  ? 63.056 -15.498 33.637 1.00 17.03 ? 144 LEU A O     1 
ATOM   343  C  CB    . LEU C 2 8  ? 64.909 -12.943 34.687 1.00 17.45 ? 144 LEU A CB    1 
ATOM   344  C  CG    . LEU C 2 8  ? 65.038 -11.415 34.551 1.00 17.63 ? 144 LEU A CG    1 
ATOM   345  C  CD1   . LEU C 2 8  ? 66.468 -10.945 34.796 1.00 18.69 ? 144 LEU A CD1   1 
ATOM   346  C  CD2   . LEU C 2 8  ? 64.551 -10.927 33.204 1.00 18.89 ? 144 LEU A CD2   1 
ATOM   347  N  N     . LYS C 2 9  ? 63.749 -15.714 35.765 1.00 16.04 ? 145 LYS A N     1 
ATOM   348  C  CA    . LYS C 2 9  ? 63.676 -17.174 35.771 1.00 15.98 ? 145 LYS A CA    1 
ATOM   349  C  C     . LYS C 2 9  ? 62.237 -17.692 35.583 1.00 15.54 ? 145 LYS A C     1 
ATOM   350  O  O     . LYS C 2 9  ? 62.009 -18.621 34.812 1.00 14.82 ? 145 LYS A O     1 
ATOM   351  C  CB    . LYS C 2 9  ? 64.277 -17.734 37.060 1.00 15.96 ? 145 LYS A CB    1 
ATOM   352  C  CG    . LYS C 2 9  ? 64.311 -19.261 37.131 1.00 18.28 ? 145 LYS A CG    1 
ATOM   353  C  CD    . LYS C 2 9  ? 65.144 -19.734 38.316 1.00 19.18 ? 145 LYS A CD    1 
ATOM   354  C  CE    . LYS C 2 9  ? 65.474 -21.207 38.217 1.00 20.21 ? 145 LYS A CE    1 
ATOM   355  N  NZ    . LYS C 2 9  ? 66.410 -21.629 39.293 1.00 19.37 ? 145 LYS A NZ    1 
ATOM   356  N  N     . PHE C 2 10 ? 61.278 -17.088 36.278 1.00 15.33 ? 146 PHE A N     1 
ATOM   357  C  CA    . PHE C 2 10 ? 59.869 -17.451 36.123 1.00 15.95 ? 146 PHE A CA    1 
ATOM   358  C  C     . PHE C 2 10 ? 59.444 -17.374 34.664 1.00 15.87 ? 146 PHE A C     1 
ATOM   359  O  O     . PHE C 2 10 ? 58.842 -18.307 34.129 1.00 15.53 ? 146 PHE A O     1 
ATOM   360  C  CB    . PHE C 2 10 ? 58.975 -16.525 36.960 1.00 16.38 ? 146 PHE A CB    1 
ATOM   361  C  CG    . PHE C 2 10 ? 57.516 -16.901 36.931 1.00 16.83 ? 146 PHE A CG    1 
ATOM   362  C  CD1   . PHE C 2 10 ? 56.653 -16.335 36.005 1.00 18.78 ? 146 PHE A CD1   1 
ATOM   363  C  CD2   . PHE C 2 10 ? 57.015 -17.832 37.830 1.00 18.73 ? 146 PHE A CD2   1 
ATOM   364  C  CE1   . PHE C 2 10 ? 55.309 -16.686 35.976 1.00 17.27 ? 146 PHE A CE1   1 
ATOM   365  C  CE2   . PHE C 2 10 ? 55.678 -18.188 37.817 1.00 18.26 ? 146 PHE A CE2   1 
ATOM   366  C  CZ    . PHE C 2 10 ? 54.820 -17.608 36.888 1.00 18.69 ? 146 PHE A CZ    1 
ATOM   367  N  N     . LEU C 2 11 ? 59.765 -16.245 34.037 1.00 16.52 ? 147 LEU A N     1 
ATOM   368  C  CA    . LEU C 2 11 ? 59.468 -16.015 32.617 1.00 17.23 ? 147 LEU A CA    1 
ATOM   369  C  C     . LEU C 2 11 ? 60.164 -17.009 31.678 1.00 17.07 ? 147 LEU A C     1 
ATOM   370  O  O     . LEU C 2 11 ? 59.553 -17.504 30.736 1.00 15.59 ? 147 LEU A O     1 
ATOM   371  C  CB    . LEU C 2 11 ? 59.842 -14.578 32.215 1.00 17.47 ? 147 LEU A CB    1 
ATOM   372  C  CG    . LEU C 2 11 ? 58.762 -13.515 32.477 1.00 19.71 ? 147 LEU A CG    1 
ATOM   373  C  CD1   . LEU C 2 11 ? 59.342 -12.106 32.369 1.00 18.39 ? 147 LEU A CD1   1 
ATOM   374  C  CD2   . LEU C 2 11 ? 57.595 -13.695 31.511 1.00 21.59 ? 147 LEU A CD2   1 
ATOM   375  N  N     . GLU C 2 12 ? 61.436 -17.292 31.944 1.00 18.27 ? 148 GLU A N     1 
ATOM   376  C  CA    . GLU C 2 12 ? 62.217 -18.219 31.109 1.00 19.60 ? 148 GLU A CA    1 
ATOM   377  C  C     . GLU C 2 12 ? 61.639 -19.622 31.174 1.00 20.62 ? 148 GLU A C     1 
ATOM   378  O  O     . GLU C 2 12 ? 61.633 -20.346 30.174 1.00 20.78 ? 148 GLU A O     1 
ATOM   379  C  CB    . GLU C 2 12 ? 63.698 -18.211 31.509 1.00 19.61 ? 148 GLU A CB    1 
ATOM   380  C  CG    . GLU C 2 12 ? 64.433 -16.987 30.987 1.00 20.13 ? 148 GLU A CG    1 
ATOM   381  C  CD    . GLU C 2 12 ? 65.919 -16.958 31.329 1.00 21.53 ? 148 GLU A CD    1 
ATOM   382  O  OE1   . GLU C 2 12 ? 66.341 -17.623 32.289 1.00 20.65 ? 148 GLU A OE1   1 
ATOM   383  O  OE2   . GLU C 2 12 ? 66.670 -16.242 30.635 1.00 23.59 ? 148 GLU A OE2   1 
ATOM   384  N  N     . GLU C 2 13 ? 61.125 -19.980 32.349 1.00 22.39 ? 149 GLU A N     1 
ATOM   385  C  CA    . GLU C 2 13 ? 60.473 -21.276 32.570 1.00 23.05 ? 149 GLU A CA    1 
ATOM   386  C  C     . GLU C 2 13 ? 59.272 -21.487 31.647 1.00 22.59 ? 149 GLU A C     1 
ATOM   387  O  O     . GLU C 2 13 ? 58.944 -22.625 31.319 1.00 23.56 ? 149 GLU A O     1 
ATOM   388  C  CB    . GLU C 2 13 ? 60.004 -21.406 34.030 1.00 23.44 ? 149 GLU A CB    1 
ATOM   389  C  CG    . GLU C 2 13 ? 60.480 -22.682 34.744 1.00 27.32 ? 149 GLU A CG    1 
ATOM   390  C  CD    . GLU C 2 13 ? 61.769 -22.486 35.517 1.00 30.60 ? 149 GLU A CD    1 
ATOM   391  O  OE1   . GLU C 2 13 ? 62.533 -21.580 35.142 1.00 37.09 ? 149 GLU A OE1   1 
ATOM   392  O  OE2   . GLU C 2 13 ? 62.023 -23.226 36.493 1.00 28.69 ? 149 GLU A OE2   1 
ATOM   393  N  N     . LEU C 2 14 ? 58.613 -20.398 31.249 1.00 22.14 ? 150 LEU A N     1 
ATOM   394  C  CA    . LEU C 2 14 ? 57.388 -20.466 30.442 1.00 21.70 ? 150 LEU A CA    1 
ATOM   395  C  C     . LEU C 2 14 ? 57.660 -20.812 28.987 1.00 21.18 ? 150 LEU A C     1 
ATOM   396  O  O     . LEU C 2 14 ? 56.811 -21.394 28.319 1.00 21.26 ? 150 LEU A O     1 
ATOM   397  C  CB    . LEU C 2 14 ? 56.626 -19.141 30.492 1.00 21.68 ? 150 LEU A CB    1 
ATOM   398  C  CG    . LEU C 2 14 ? 56.094 -18.677 31.845 1.00 21.77 ? 150 LEU A CG    1 
ATOM   399  C  CD1   . LEU C 2 14 ? 55.500 -17.283 31.723 1.00 22.25 ? 150 LEU A CD1   1 
ATOM   400  C  CD2   . LEU C 2 14 ? 55.069 -19.646 32.388 1.00 23.28 ? 150 LEU A CD2   1 
ATOM   401  N  N     . GLY C 2 15 ? 58.845 -20.452 28.510 1.00 20.69 ? 151 GLY A N     1 
ATOM   402  C  CA    . GLY C 2 15 ? 59.235 -20.680 27.133 1.00 20.08 ? 151 GLY A CA    1 
ATOM   403  C  C     . GLY C 2 15 ? 59.385 -19.350 26.426 1.00 19.88 ? 151 GLY A C     1 
ATOM   404  O  O     . GLY C 2 15 ? 58.879 -18.327 26.895 1.00 18.13 ? 151 GLY A O     1 
ATOM   405  N  N     . GLU C 2 16 ? 60.079 -19.372 25.293 1.00 19.98 ? 152 GLU A N     1 
ATOM   406  C  CA    . GLU C 2 16 ? 60.339 -18.162 24.513 1.00 20.49 ? 152 GLU A CA    1 
ATOM   407  C  C     . GLU C 2 16 ? 59.047 -17.454 24.090 1.00 20.84 ? 152 GLU A C     1 
ATOM   408  O  O     . GLU C 2 16 ? 58.048 -18.097 23.759 1.00 20.21 ? 152 GLU A O     1 
ATOM   409  C  CB    . GLU C 2 16 ? 61.183 -18.494 23.281 1.00 20.59 ? 152 GLU A CB    1 
ATOM   410  C  CG    . GLU C 2 16 ? 62.609 -18.920 23.612 1.00 21.59 ? 152 GLU A CG    1 
ATOM   411  C  CD    . GLU C 2 16 ? 63.430 -19.235 22.373 1.00 23.60 ? 152 GLU A CD    1 
ATOM   412  O  OE1   . GLU C 2 16 ? 63.575 -20.435 22.059 1.00 20.00 ? 152 GLU A OE1   1 
ATOM   413  O  OE2   . GLU C 2 16 ? 63.915 -18.284 21.706 1.00 23.61 ? 152 GLU A OE2   1 
ATOM   414  N  N     . GLY C 2 17 ? 59.078 -16.126 24.156 1.00 22.18 ? 153 GLY A N     1 
ATOM   415  C  CA    . GLY C 2 17 ? 57.978 -15.282 23.715 1.00 23.55 ? 153 GLY A CA    1 
ATOM   416  C  C     . GLY C 2 17 ? 56.766 -15.224 24.634 1.00 24.88 ? 153 GLY A C     1 
ATOM   417  O  O     . GLY C 2 17 ? 55.813 -14.500 24.344 1.00 24.91 ? 153 GLY A O     1 
ATOM   418  N  N     . LYS C 2 18 ? 56.786 -15.979 25.732 1.00 25.64 ? 154 LYS A N     1 
ATOM   419  C  CA    . LYS C 2 18 ? 55.633 -16.050 26.628 1.00 26.33 ? 154 LYS A CA    1 
ATOM   420  C  C     . LYS C 2 18 ? 55.591 -14.805 27.503 1.00 25.95 ? 154 LYS A C     1 
ATOM   421  O  O     . LYS C 2 18 ? 56.633 -14.231 27.837 1.00 25.96 ? 154 LYS A O     1 
ATOM   422  C  CB    . LYS C 2 18 ? 55.663 -17.320 27.497 1.00 26.84 ? 154 LYS A CB    1 
ATOM   423  C  CG    . LYS C 2 18 ? 54.631 -18.378 27.104 1.00 29.44 ? 154 LYS A CG    1 
ATOM   424  C  CD    . LYS C 2 18 ? 54.894 -18.955 25.721 1.00 32.54 ? 154 LYS A CD    1 
ATOM   425  C  CE    . LYS C 2 18 ? 53.678 -19.698 25.182 1.00 33.72 ? 154 LYS A CE    1 
ATOM   426  N  NZ    . LYS C 2 18 ? 53.269 -20.827 26.056 1.00 35.33 ? 154 LYS A NZ    1 
ATOM   427  N  N     . ALA C 2 19 ? 54.381 -14.396 27.871 1.00 25.48 ? 155 ALA A N     1 
ATOM   428  C  CA    . ALA C 2 19 ? 54.189 -13.194 28.677 1.00 25.06 ? 155 ALA A CA    1 
ATOM   429  C  C     . ALA C 2 19 ? 53.398 -13.524 29.933 1.00 24.17 ? 155 ALA A C     1 
ATOM   430  O  O     . ALA C 2 19 ? 52.690 -14.519 29.977 1.00 25.01 ? 155 ALA A O     1 
ATOM   431  C  CB    . ALA C 2 19 ? 53.490 -12.112 27.867 1.00 24.79 ? 155 ALA A CB    1 
ATOM   432  N  N     . THR C 2 20 ? 53.555 -12.684 30.954 1.00 23.04 ? 156 THR A N     1 
ATOM   433  C  CA    . THR C 2 20 ? 52.822 -12.804 32.212 1.00 21.45 ? 156 THR A CA    1 
ATOM   434  C  C     . THR C 2 20 ? 52.512 -11.395 32.757 1.00 20.10 ? 156 THR A C     1 
ATOM   435  O  O     . THR C 2 20 ? 53.055 -10.404 32.271 1.00 19.37 ? 156 THR A O     1 
ATOM   436  C  CB    . THR C 2 20 ? 53.640 -13.618 33.262 1.00 21.66 ? 156 THR A CB    1 
ATOM   437  O  OG1   . THR C 2 20 ? 52.807 -13.962 34.371 1.00 22.96 ? 156 THR A OG1   1 
ATOM   438  C  CG2   . THR C 2 20 ? 54.850 -12.832 33.778 1.00 21.42 ? 156 THR A CG2   1 
ATOM   439  N  N     . THR C 2 21 ? 51.641 -11.336 33.767 1.00 18.63 ? 157 THR A N     1 
ATOM   440  C  CA    . THR C 2 21 ? 51.264 -10.097 34.443 1.00 17.37 ? 157 THR A CA    1 
ATOM   441  C  C     . THR C 2 21 ? 51.897 -9.993  35.832 1.00 17.39 ? 157 THR A C     1 
ATOM   442  O  O     . THR C 2 21 ? 52.285 -11.011 36.434 1.00 17.19 ? 157 THR A O     1 
ATOM   443  C  CB    . THR C 2 21 ? 49.748 -10.037 34.619 1.00 17.61 ? 157 THR A CB    1 
ATOM   444  O  OG1   . THR C 2 21 ? 49.316 -11.126 35.446 1.00 17.91 ? 157 THR A OG1   1 
ATOM   445  C  CG2   . THR C 2 21 ? 49.049 -10.118 33.270 1.00 17.24 ? 157 THR A CG2   1 
ATOM   446  N  N     . ALA C 2 22 ? 51.978 -8.762  36.344 1.00 16.96 ? 158 ALA A N     1 
ATOM   447  C  CA    . ALA C 2 22 ? 52.465 -8.507  37.701 1.00 17.12 ? 158 ALA A CA    1 
ATOM   448  C  C     . ALA C 2 22 ? 51.597 -9.215  38.744 1.00 17.51 ? 158 ALA A C     1 
ATOM   449  O  O     . ALA C 2 22 ? 52.095 -9.713  39.756 1.00 16.86 ? 158 ALA A O     1 
ATOM   450  C  CB    . ALA C 2 22 ? 52.490 -7.018  37.984 1.00 17.40 ? 158 ALA A CB    1 
ATOM   451  N  N     . HIS C 2 23 ? 50.294 -9.220  38.473 1.00 18.13 ? 159 HIS A N     1 
ATOM   452  C  CA    . HIS C 2 23 ? 49.277 -9.905  39.262 1.00 18.96 ? 159 HIS A CA    1 
ATOM   453  C  C     . HIS C 2 23 ? 49.687 -11.367 39.467 1.00 18.93 ? 159 HIS A C     1 
ATOM   454  O  O     . HIS C 2 23 ? 49.776 -11.864 40.599 1.00 18.02 ? 159 HIS A O     1 
ATOM   455  C  CB    . HIS C 2 23 ? 47.947 -9.808  38.482 1.00 19.88 ? 159 HIS A CB    1 
ATOM   456  C  CG    . HIS C 2 23 ? 46.745 -10.307 39.220 1.00 22.67 ? 159 HIS A CG    1 
ATOM   457  N  ND1   . HIS C 2 23 ? 45.945 -9.481  39.985 1.00 25.59 ? 159 HIS A ND1   1 
ATOM   458  C  CD2   . HIS C 2 23 ? 46.176 -11.535 39.270 1.00 23.97 ? 159 HIS A CD2   1 
ATOM   459  C  CE1   . HIS C 2 23 ? 44.953 -10.188 40.497 1.00 25.81 ? 159 HIS A CE1   1 
ATOM   460  N  NE2   . HIS C 2 23 ? 45.067 -11.435 40.076 1.00 24.63 ? 159 HIS A NE2   1 
ATOM   461  N  N     . ASP C 2 24 ? 49.981 -12.031 38.355 1.00 19.18 ? 160 ASP A N     1 
ATOM   462  C  CA    . ASP C 2 24 ? 50.389 -13.429 38.360 1.00 19.76 ? 160 ASP A CA    1 
ATOM   463  C  C     . ASP C 2 24 ? 51.725 -13.625 39.070 1.00 19.30 ? 160 ASP A C     1 
ATOM   464  O  O     . ASP C 2 24 ? 51.865 -14.517 39.914 1.00 18.53 ? 160 ASP A O     1 
ATOM   465  C  CB    . ASP C 2 24 ? 50.475 -13.955 36.926 1.00 20.72 ? 160 ASP A CB    1 
ATOM   466  C  CG    . ASP C 2 24 ? 50.668 -15.456 36.862 1.00 23.95 ? 160 ASP A CG    1 
ATOM   467  O  OD1   . ASP C 2 24 ? 49.913 -16.196 37.537 1.00 29.08 ? 160 ASP A OD1   1 
ATOM   468  O  OD2   . ASP C 2 24 ? 51.577 -15.902 36.128 1.00 29.00 ? 160 ASP A OD2   1 
ATOM   469  N  N     . LEU C 2 25 ? 52.709 -12.796 38.733 1.00 19.39 ? 161 LEU A N     1 
ATOM   470  C  CA    . LEU C 2 25 ? 54.037 -12.917 39.344 1.00 19.03 ? 161 LEU A CA    1 
ATOM   471  C  C     . LEU C 2 25 ? 53.945 -12.770 40.859 1.00 18.33 ? 161 LEU A C     1 
ATOM   472  O  O     . LEU C 2 25 ? 54.586 -13.513 41.610 1.00 18.14 ? 161 LEU A O     1 
ATOM   473  C  CB    . LEU C 2 25 ? 55.000 -11.865 38.784 1.00 19.37 ? 161 LEU A CB    1 
ATOM   474  C  CG    . LEU C 2 25 ? 55.658 -12.194 37.444 1.00 20.96 ? 161 LEU A CG    1 
ATOM   475  C  CD1   . LEU C 2 25 ? 56.159 -10.934 36.760 1.00 21.47 ? 161 LEU A CD1   1 
ATOM   476  C  CD2   . LEU C 2 25 ? 56.791 -13.195 37.621 1.00 20.66 ? 161 LEU A CD2   1 
ATOM   477  N  N     . SER C 2 26 ? 53.148 -11.799 41.298 1.00 18.20 ? 162 SER A N     1 
ATOM   478  C  CA    . SER C 2 26 ? 52.956 -11.540 42.720 1.00 17.47 ? 162 SER A CA    1 
ATOM   479  C  C     . SER C 2 26 ? 52.462 -12.774 43.460 1.00 17.59 ? 162 SER A C     1 
ATOM   480  O  O     . SER C 2 26 ? 52.983 -13.109 44.511 1.00 17.10 ? 162 SER A O     1 
ATOM   481  C  CB    . SER C 2 26 ? 51.978 -10.394 42.945 1.00 17.40 ? 162 SER A CB    1 
ATOM   482  O  OG    . SER C 2 26 ? 51.664 -10.276 44.325 1.00 16.20 ? 162 SER A OG    1 
ATOM   483  N  N     . GLY C 2 27 ? 51.467 -13.451 42.894 1.00 17.94 ? 163 GLY A N     1 
ATOM   484  C  CA    . GLY C 2 27 ? 50.919 -14.664 43.499 1.00 18.16 ? 163 GLY A CA    1 
ATOM   485  C  C     . GLY C 2 27 ? 51.883 -15.833 43.517 1.00 17.86 ? 163 GLY A C     1 
ATOM   486  O  O     . GLY C 2 27 ? 52.089 -16.445 44.553 1.00 16.97 ? 163 GLY A O     1 
ATOM   487  N  N     . LYS C 2 28 ? 52.478 -16.131 42.363 1.00 17.95 ? 164 LYS A N     1 
ATOM   488  C  CA    . LYS C 2 28 ? 53.356 -17.296 42.211 1.00 18.02 ? 164 LYS A CA    1 
ATOM   489  C  C     . LYS C 2 28 ? 54.669 -17.165 42.976 1.00 18.01 ? 164 LYS A C     1 
ATOM   490  O  O     . LYS C 2 28 ? 55.166 -18.150 43.519 1.00 17.63 ? 164 LYS A O     1 
ATOM   491  C  CB    . LYS C 2 28 ? 53.652 -17.556 40.732 1.00 17.98 ? 164 LYS A CB    1 
ATOM   492  C  CG    . LYS C 2 28 ? 52.437 -18.026 39.920 1.00 20.75 ? 164 LYS A CG    1 
ATOM   493  C  CD    . LYS C 2 28 ? 52.178 -19.523 40.088 1.00 21.77 ? 164 LYS A CD    1 
ATOM   494  C  CE    . LYS C 2 28 ? 50.906 -19.960 39.357 1.00 23.58 ? 164 LYS A CE    1 
ATOM   495  N  NZ    . LYS C 2 28 ? 50.416 -21.298 39.846 1.00 24.50 ? 164 LYS A NZ    1 
ATOM   496  N  N     . LEU C 2 29 ? 55.231 -15.955 43.000 1.00 18.44 ? 165 LEU A N     1 
ATOM   497  C  CA    . LEU C 2 29 ? 56.510 -15.703 43.668 1.00 17.99 ? 165 LEU A CA    1 
ATOM   498  C  C     . LEU C 2 29 ? 56.337 -15.245 45.111 1.00 18.02 ? 165 LEU A C     1 
ATOM   499  O  O     . LEU C 2 29 ? 57.321 -15.053 45.814 1.00 17.79 ? 165 LEU A O     1 
ATOM   500  C  CB    . LEU C 2 29 ? 57.322 -14.663 42.893 1.00 17.80 ? 165 LEU A CB    1 
ATOM   501  C  CG    . LEU C 2 29 ? 57.788 -15.072 41.495 1.00 17.86 ? 165 LEU A CG    1 
ATOM   502  C  CD1   . LEU C 2 29 ? 58.391 -13.880 40.758 1.00 19.27 ? 165 LEU A CD1   1 
ATOM   503  C  CD2   . LEU C 2 29 ? 58.788 -16.197 41.562 1.00 16.27 ? 165 LEU A CD2   1 
ATOM   504  N  N     . GLY C 2 30 ? 55.091 -15.055 45.543 1.00 17.99 ? 166 GLY A N     1 
ATOM   505  C  CA    . GLY C 2 30 ? 54.799 -14.711 46.927 1.00 18.09 ? 166 GLY A CA    1 
ATOM   506  C  C     . GLY C 2 30 ? 55.401 -13.378 47.308 1.00 17.84 ? 166 GLY A C     1 
ATOM   507  O  O     . GLY C 2 30 ? 56.064 -13.258 48.337 1.00 18.08 ? 166 GLY A O     1 
ATOM   508  N  N     . THR C 2 31 ? 55.146 -12.378 46.473 1.00 17.68 ? 167 THR A N     1 
ATOM   509  C  CA    . THR C 2 31 ? 55.772 -11.065 46.586 1.00 17.62 ? 167 THR A CA    1 
ATOM   510  C  C     . THR C 2 31 ? 54.722 -9.986  46.296 1.00 16.72 ? 167 THR A C     1 
ATOM   511  O  O     . THR C 2 31 ? 53.990 -10.104 45.315 1.00 16.42 ? 167 THR A O     1 
ATOM   512  C  CB    . THR C 2 31 ? 56.943 -10.954 45.577 1.00 17.54 ? 167 THR A CB    1 
ATOM   513  O  OG1   . THR C 2 31 ? 57.979 -11.870 45.956 1.00 19.66 ? 167 THR A OG1   1 
ATOM   514  C  CG2   . THR C 2 31 ? 57.526 -9.539  45.525 1.00 18.38 ? 167 THR A CG2   1 
ATOM   515  N  N     . PRO C 2 32 ? 54.650 -8.927  47.134 1.00 15.89 ? 168 PRO A N     1 
ATOM   516  C  CA    . PRO C 2 32 ? 53.624 -7.909  46.875 1.00 15.38 ? 168 PRO A CA    1 
ATOM   517  C  C     . PRO C 2 32 ? 53.742 -7.320  45.469 1.00 14.85 ? 168 PRO A C     1 
ATOM   518  O  O     . PRO C 2 32 ? 54.847 -7.129  44.979 1.00 13.47 ? 168 PRO A O     1 
ATOM   519  C  CB    . PRO C 2 32 ? 53.891 -6.843  47.957 1.00 15.33 ? 168 PRO A CB    1 
ATOM   520  C  CG    . PRO C 2 32 ? 54.614 -7.569  49.038 1.00 15.72 ? 168 PRO A CG    1 
ATOM   521  C  CD    . PRO C 2 32 ? 55.460 -8.592  48.324 1.00 15.61 ? 168 PRO A CD    1 
ATOM   522  N  N     . LYS C 2 33 ? 52.598 -7.059  44.832 1.00 14.70 ? 169 LYS A N     1 
ATOM   523  C  CA    . LYS C 2 33 ? 52.568 -6.610  43.444 1.00 15.04 ? 169 LYS A CA    1 
ATOM   524  C  C     . LYS C 2 33 ? 53.312 -5.290  43.247 1.00 15.98 ? 169 LYS A C     1 
ATOM   525  O  O     . LYS C 2 33 ? 53.915 -5.071  42.200 1.00 15.36 ? 169 LYS A O     1 
ATOM   526  C  CB    . LYS C 2 33 ? 51.129 -6.496  42.942 1.00 15.37 ? 169 LYS A CB    1 
ATOM   527  C  CG    . LYS C 2 33 ? 50.997 -6.304  41.431 1.00 14.29 ? 169 LYS A CG    1 
ATOM   528  C  CD    . LYS C 2 33 ? 49.571 -6.476  40.945 1.00 15.04 ? 169 LYS A CD    1 
ATOM   529  C  CE    . LYS C 2 33 ? 48.604 -5.420  41.512 1.00 15.02 ? 169 LYS A CE    1 
ATOM   530  N  NZ    . LYS C 2 33 ? 48.840 -4.070  40.954 1.00 15.15 ? 169 LYS A NZ    1 
ATOM   531  N  N     . LYS C 2 34 ? 53.279 -4.430  44.263 1.00 17.09 ? 170 LYS A N     1 
ATOM   532  C  CA    . LYS C 2 34 ? 54.009 -3.155  44.239 1.00 18.29 ? 170 LYS A CA    1 
ATOM   533  C  C     . LYS C 2 34 ? 55.513 -3.376  44.010 1.00 18.16 ? 170 LYS A C     1 
ATOM   534  O  O     . LYS C 2 34 ? 56.141 -2.669  43.218 1.00 17.77 ? 170 LYS A O     1 
ATOM   535  C  CB    . LYS C 2 34 ? 53.753 -2.383  45.539 1.00 18.86 ? 170 LYS A CB    1 
ATOM   536  C  CG    . LYS C 2 34 ? 54.156 -0.918  45.533 1.00 22.78 ? 170 LYS A CG    1 
ATOM   537  C  CD    . LYS C 2 34 ? 53.191 -0.085  46.405 1.00 27.71 ? 170 LYS A CD    1 
ATOM   538  C  CE    . LYS C 2 34 ? 53.680 1.352   46.685 1.00 29.50 ? 170 LYS A CE    1 
ATOM   539  N  NZ    . LYS C 2 34 ? 52.659 2.180   47.436 1.00 29.54 ? 170 LYS A NZ    1 
ATOM   540  N  N     . GLU C 2 35 ? 56.072 -4.371  44.696 1.00 18.54 ? 171 GLU A N     1 
ATOM   541  C  CA    . GLU C 2 35 ? 57.480 -4.731  44.537 1.00 19.01 ? 171 GLU A CA    1 
ATOM   542  C  C     . GLU C 2 35 ? 57.741 -5.359  43.177 1.00 18.08 ? 171 GLU A C     1 
ATOM   543  O  O     . GLU C 2 35 ? 58.711 -4.992  42.498 1.00 17.65 ? 171 GLU A O     1 
ATOM   544  C  CB    . GLU C 2 35 ? 57.922 -5.705  45.626 1.00 19.83 ? 171 GLU A CB    1 
ATOM   545  C  CG    . GLU C 2 35 ? 59.422 -5.945  45.621 1.00 23.65 ? 171 GLU A CG    1 
ATOM   546  C  CD    . GLU C 2 35 ? 59.894 -6.834  46.755 1.00 29.48 ? 171 GLU A CD    1 
ATOM   547  O  OE1   . GLU C 2 35 ? 60.819 -7.641  46.495 1.00 32.32 ? 171 GLU A OE1   1 
ATOM   548  O  OE2   . GLU C 2 35 ? 59.353 -6.723  47.894 1.00 32.15 ? 171 GLU A OE2   1 
ATOM   549  N  N     . ILE C 2 36 ? 56.884 -6.320  42.796 1.00 17.25 ? 172 ILE A N     1 
ATOM   550  C  CA    . ILE C 2 36 ? 56.946 -6.936  41.466 1.00 16.38 ? 172 ILE A CA    1 
ATOM   551  C  C     . ILE C 2 36 ? 57.012 -5.822  40.420 1.00 15.88 ? 172 ILE A C     1 
ATOM   552  O  O     . ILE C 2 36 ? 57.908 -5.813  39.580 1.00 16.06 ? 172 ILE A O     1 
ATOM   553  C  CB    . ILE C 2 36 ? 55.745 -7.891  41.176 1.00 16.65 ? 172 ILE A CB    1 
ATOM   554  C  CG1   . ILE C 2 36 ? 55.798 -9.167  42.040 1.00 17.94 ? 172 ILE A CG1   1 
ATOM   555  C  CG2   . ILE C 2 36 ? 55.697 -8.295  39.715 1.00 17.43 ? 172 ILE A CG2   1 
ATOM   556  C  CD1   . ILE C 2 36 ? 56.995 -10.101 41.781 1.00 18.62 ? 172 ILE A CD1   1 
ATOM   557  N  N     . ASN C 2 37 ? 56.098 -4.859  40.504 1.00 15.61 ? 173 ASN A N     1 
ATOM   558  C  CA    . ASN C 2 37 ? 56.031 -3.805  39.482 1.00 16.41 ? 173 ASN A CA    1 
ATOM   559  C  C     . ASN C 2 37 ? 57.261 -2.890  39.487 1.00 16.13 ? 173 ASN A C     1 
ATOM   560  O  O     . ASN C 2 37 ? 57.769 -2.536  38.428 1.00 16.13 ? 173 ASN A O     1 
ATOM   561  C  CB    . ASN C 2 37 ? 54.727 -2.989  39.587 1.00 16.40 ? 173 ASN A CB    1 
ATOM   562  C  CG    . ASN C 2 37 ? 53.586 -3.594  38.788 1.00 16.87 ? 173 ASN A CG    1 
ATOM   563  O  OD1   . ASN C 2 37 ? 53.800 -4.188  37.722 1.00 18.75 ? 173 ASN A OD1   1 
ATOM   564  N  ND2   . ASN C 2 37 ? 52.357 -3.427  39.285 1.00 16.31 ? 173 ASN A ND2   1 
ATOM   565  N  N     . ARG C 2 38 ? 57.747 -2.525  40.670 1.00 16.87 ? 174 ARG A N     1 
ATOM   566  C  CA    . ARG C 2 38 ? 58.989 -1.749  40.772 1.00 18.12 ? 174 ARG A CA    1 
ATOM   567  C  C     . ARG C 2 38 ? 60.130 -2.398  39.969 1.00 18.05 ? 174 ARG A C     1 
ATOM   568  O  O     . ARG C 2 38 ? 60.874 -1.708  39.266 1.00 18.56 ? 174 ARG A O     1 
ATOM   569  C  CB    . ARG C 2 38 ? 59.434 -1.577  42.231 1.00 18.28 ? 174 ARG A CB    1 
ATOM   570  C  CG    . ARG C 2 38 ? 60.400 -0.395  42.431 1.00 20.97 ? 174 ARG A CG    1 
ATOM   571  C  CD    . ARG C 2 38 ? 61.490 -0.632  43.485 1.00 24.20 ? 174 ARG A CD    1 
ATOM   572  N  NE    . ARG C 2 38 ? 60.973 -1.208  44.731 1.00 28.71 ? 174 ARG A NE    1 
ATOM   573  C  CZ    . ARG C 2 38 ? 61.442 -2.309  45.327 1.00 33.50 ? 174 ARG A CZ    1 
ATOM   574  N  NH1   . ARG C 2 38 ? 60.880 -2.727  46.463 1.00 34.76 ? 174 ARG A NH1   1 
ATOM   575  N  NH2   . ARG C 2 38 ? 62.472 -2.994  44.822 1.00 35.10 ? 174 ARG A NH2   1 
ATOM   576  N  N     . VAL C 2 39 ? 60.255 -3.717  40.086 1.00 18.05 ? 175 VAL A N     1 
ATOM   577  C  CA    . VAL C 2 39 ? 61.332 -4.469  39.417 1.00 18.17 ? 175 VAL A CA    1 
ATOM   578  C  C     . VAL C 2 39 ? 61.031 -4.687  37.927 1.00 17.82 ? 175 VAL A C     1 
ATOM   579  O  O     . VAL C 2 39 ? 61.940 -4.651  37.103 1.00 17.90 ? 175 VAL A O     1 
ATOM   580  C  CB    . VAL C 2 39 ? 61.618 -5.822  40.137 1.00 18.05 ? 175 VAL A CB    1 
ATOM   581  C  CG1   . VAL C 2 39 ? 62.567 -6.709  39.332 1.00 19.96 ? 175 VAL A CG1   1 
ATOM   582  C  CG2   . VAL C 2 39 ? 62.187 -5.567  41.507 1.00 17.80 ? 175 VAL A CG2   1 
ATOM   583  N  N     . LEU C 2 40 ? 59.766 -4.912  37.583 1.00 17.93 ? 176 LEU A N     1 
ATOM   584  C  CA    . LEU C 2 40 ? 59.366 -5.058  36.174 1.00 17.92 ? 176 LEU A CA    1 
ATOM   585  C  C     . LEU C 2 40 ? 59.642 -3.794  35.350 1.00 18.35 ? 176 LEU A C     1 
ATOM   586  O  O     . LEU C 2 40 ? 60.205 -3.870  34.248 1.00 18.43 ? 176 LEU A O     1 
ATOM   587  C  CB    . LEU C 2 40 ? 57.875 -5.409  36.052 1.00 18.04 ? 176 LEU A CB    1 
ATOM   588  C  CG    . LEU C 2 40 ? 57.417 -6.814  36.439 1.00 18.74 ? 176 LEU A CG    1 
ATOM   589  C  CD1   . LEU C 2 40 ? 55.893 -6.921  36.337 1.00 18.04 ? 176 LEU A CD1   1 
ATOM   590  C  CD2   . LEU C 2 40 ? 58.097 -7.880  35.567 1.00 18.75 ? 176 LEU A CD2   1 
ATOM   591  N  N     . TYR C 2 41 ? 59.235 -2.637  35.868 1.00 18.85 ? 177 TYR A N     1 
ATOM   592  C  CA    . TYR C 2 41 ? 59.481 -1.364  35.164 1.00 19.48 ? 177 TYR A CA    1 
ATOM   593  C  C     . TYR C 2 41 ? 60.975 -1.017  35.089 1.00 20.17 ? 177 TYR A C     1 
ATOM   594  O  O     . TYR C 2 41 ? 61.428 -0.445  34.090 1.00 20.68 ? 177 TYR A O     1 
ATOM   595  C  CB    . TYR C 2 41 ? 58.671 -0.216  35.781 1.00 19.36 ? 177 TYR A CB    1 
ATOM   596  C  CG    . TYR C 2 41 ? 57.204 -0.267  35.396 1.00 20.56 ? 177 TYR A CG    1 
ATOM   597  C  CD1   . TYR C 2 41 ? 56.317 -1.108  36.062 1.00 20.48 ? 177 TYR A CD1   1 
ATOM   598  C  CD2   . TYR C 2 41 ? 56.710 0.500   34.345 1.00 21.43 ? 177 TYR A CD2   1 
ATOM   599  C  CE1   . TYR C 2 41 ? 54.984 -1.176  35.711 1.00 20.84 ? 177 TYR A CE1   1 
ATOM   600  C  CE2   . TYR C 2 41 ? 55.368 0.440   33.984 1.00 21.17 ? 177 TYR A CE2   1 
ATOM   601  C  CZ    . TYR C 2 41 ? 54.510 -0.396  34.677 1.00 20.93 ? 177 TYR A CZ    1 
ATOM   602  O  OH    . TYR C 2 41 ? 53.186 -0.473  34.327 1.00 18.64 ? 177 TYR A OH    1 
ATOM   603  N  N     . SER C 2 42 ? 61.732 -1.369  36.127 1.00 20.79 ? 178 SER A N     1 
ATOM   604  C  CA    . SER C 2 42 ? 63.176 -1.148  36.133 1.00 21.81 ? 178 SER A CA    1 
ATOM   605  C  C     . SER C 2 42 ? 63.876 -1.999  35.076 1.00 22.58 ? 178 SER A C     1 
ATOM   606  O  O     . SER C 2 42 ? 64.649 -1.484  34.264 1.00 22.25 ? 178 SER A O     1 
ATOM   607  C  CB    . SER C 2 42 ? 63.760 -1.455  37.511 1.00 22.43 ? 178 SER A CB    1 
ATOM   608  O  OG    . SER C 2 42 ? 65.178 -1.478  37.469 1.00 24.44 ? 178 SER A OG    1 
ATOM   609  N  N     . LEU C 2 43 ? 63.594 -3.300  35.095 1.00 23.11 ? 179 LEU A N     1 
ATOM   610  C  CA    . LEU C 2 43 ? 64.147 -4.241  34.121 1.00 23.61 ? 179 LEU A CA    1 
ATOM   611  C  C     . LEU C 2 43 ? 63.879 -3.812  32.690 1.00 24.72 ? 179 LEU A C     1 
ATOM   612  O  O     . LEU C 2 43 ? 64.756 -3.936  31.827 1.00 25.24 ? 179 LEU A O     1 
ATOM   613  C  CB    . LEU C 2 43 ? 63.586 -5.653  34.344 1.00 23.59 ? 179 LEU A CB    1 
ATOM   614  C  CG    . LEU C 2 43 ? 64.211 -6.404  35.520 1.00 22.63 ? 179 LEU A CG    1 
ATOM   615  C  CD1   . LEU C 2 43 ? 63.411 -7.652  35.871 1.00 22.51 ? 179 LEU A CD1   1 
ATOM   616  C  CD2   . LEU C 2 43 ? 65.666 -6.760  35.232 1.00 22.78 ? 179 LEU A CD2   1 
ATOM   617  N  N     . ALA C 2 44 ? 62.667 -3.314  32.446 1.00 25.60 ? 180 ALA A N     1 
ATOM   618  C  CA    . ALA C 2 44 ? 62.277 -2.790  31.141 1.00 26.09 ? 180 ALA A CA    1 
ATOM   619  C  C     . ALA C 2 44 ? 63.153 -1.607  30.726 1.00 27.29 ? 180 ALA A C     1 
ATOM   620  O  O     . ALA C 2 44 ? 63.575 -1.504  29.575 1.00 27.45 ? 180 ALA A O     1 
ATOM   621  C  CB    . ALA C 2 44 ? 60.817 -2.379  31.167 1.00 26.34 ? 180 ALA A CB    1 
ATOM   622  N  N     . LYS C 2 45 ? 63.423 -0.726  31.680 1.00 28.67 ? 181 LYS A N     1 
ATOM   623  C  CA    . LYS C 2 45 ? 64.296 0.420   31.467 1.00 29.81 ? 181 LYS A CA    1 
ATOM   624  C  C     . LYS C 2 45 ? 65.726 -0.027  31.144 1.00 29.69 ? 181 LYS A C     1 
ATOM   625  O  O     . LYS C 2 45 ? 66.433 0.614   30.358 1.00 29.81 ? 181 LYS A O     1 
ATOM   626  C  CB    . LYS C 2 45 ? 64.297 1.298   32.720 1.00 30.60 ? 181 LYS A CB    1 
ATOM   627  C  CG    . LYS C 2 45 ? 64.502 2.778   32.461 1.00 32.95 ? 181 LYS A CG    1 
ATOM   628  C  CD    . LYS C 2 45 ? 64.486 3.580   33.760 1.00 36.87 ? 181 LYS A CD    1 
ATOM   629  C  CE    . LYS C 2 45 ? 63.235 3.335   34.609 1.00 38.42 ? 181 LYS A CE    1 
ATOM   630  N  NZ    . LYS C 2 45 ? 63.330 4.024   35.929 1.00 41.12 ? 181 LYS A NZ    1 
ATOM   631  N  N     . LYS C 2 46 ? 66.142 -1.126  31.766 1.00 29.09 ? 182 LYS A N     1 
ATOM   632  C  CA    . LYS C 2 46 ? 67.443 -1.729  31.506 1.00 29.08 ? 182 LYS A CA    1 
ATOM   633  C  C     . LYS C 2 46 ? 67.465 -2.552  30.214 1.00 29.05 ? 182 LYS A C     1 
ATOM   634  O  O     . LYS C 2 46 ? 68.534 -2.978  29.765 1.00 29.48 ? 182 LYS A O     1 
ATOM   635  C  CB    . LYS C 2 46 ? 67.870 -2.585  32.700 1.00 29.47 ? 182 LYS A CB    1 
ATOM   636  C  CG    . LYS C 2 46 ? 68.115 -1.754  33.954 1.00 30.25 ? 182 LYS A CG    1 
ATOM   637  C  CD    . LYS C 2 46 ? 68.947 -2.479  34.993 1.00 31.92 ? 182 LYS A CD    1 
ATOM   638  C  CE    . LYS C 2 46 ? 68.123 -3.021  36.145 1.00 32.52 ? 182 LYS A CE    1 
ATOM   639  N  NZ    . LYS C 2 46 ? 68.998 -3.201  37.350 1.00 31.95 ? 182 LYS A NZ    1 
ATOM   640  N  N     . GLY C 2 47 ? 66.289 -2.767  29.623 1.00 28.75 ? 183 GLY A N     1 
ATOM   641  C  CA    . GLY C 2 47 ? 66.159 -3.457  28.342 1.00 28.45 ? 183 GLY A CA    1 
ATOM   642  C  C     . GLY C 2 47 ? 66.174 -4.965  28.470 1.00 28.07 ? 183 GLY A C     1 
ATOM   643  O  O     . GLY C 2 47 ? 66.345 -5.673  27.481 1.00 28.10 ? 183 GLY A O     1 
ATOM   644  N  N     . LYS C 2 48 ? 65.992 -5.455  29.692 1.00 28.04 ? 184 LYS A N     1 
ATOM   645  C  CA    . LYS C 2 48 ? 65.935 -6.893  29.953 1.00 27.80 ? 184 LYS A CA    1 
ATOM   646  C  C     . LYS C 2 48 ? 64.530 -7.459  29.745 1.00 27.13 ? 184 LYS A C     1 
ATOM   647  O  O     . LYS C 2 48 ? 64.377 -8.640  29.445 1.00 26.68 ? 184 LYS A O     1 
ATOM   648  C  CB    . LYS C 2 48 ? 66.439 -7.195  31.366 1.00 28.52 ? 184 LYS A CB    1 
ATOM   649  C  CG    . LYS C 2 48 ? 67.950 -7.004  31.509 1.00 30.54 ? 184 LYS A CG    1 
ATOM   650  C  CD    . LYS C 2 48 ? 68.446 -7.432  32.876 1.00 33.89 ? 184 LYS A CD    1 
ATOM   651  C  CE    . LYS C 2 48 ? 69.926 -7.832  32.858 1.00 35.91 ? 184 LYS A CE    1 
ATOM   652  N  NZ    . LYS C 2 48 ? 70.306 -8.611  34.085 1.00 35.76 ? 184 LYS A NZ    1 
ATOM   653  N  N     . LEU C 2 49 ? 63.512 -6.614  29.898 1.00 27.09 ? 185 LEU A N     1 
ATOM   654  C  CA    . LEU C 2 49 ? 62.124 -7.016  29.671 1.00 27.31 ? 185 LEU A CA    1 
ATOM   655  C  C     . LEU C 2 49 ? 61.422 -6.093  28.686 1.00 27.32 ? 185 LEU A C     1 
ATOM   656  O  O     . LEU C 2 49 ? 61.777 -4.926  28.547 1.00 26.98 ? 185 LEU A O     1 
ATOM   657  C  CB    . LEU C 2 49 ? 61.335 -7.021  30.989 1.00 27.41 ? 185 LEU A CB    1 
ATOM   658  C  CG    . LEU C 2 49 ? 61.611 -8.117  32.027 1.00 28.29 ? 185 LEU A CG    1 
ATOM   659  C  CD1   . LEU C 2 49 ? 60.595 -8.013  33.157 1.00 29.56 ? 185 LEU A CD1   1 
ATOM   660  C  CD2   . LEU C 2 49 ? 61.572 -9.508  31.430 1.00 27.98 ? 185 LEU A CD2   1 
ATOM   661  N  N     . GLN C 2 50 ? 60.420 -6.639  28.010 1.00 27.98 ? 186 GLN A N     1 
ATOM   662  C  CA    . GLN C 2 50 ? 59.538 -5.867  27.148 1.00 28.79 ? 186 GLN A CA    1 
ATOM   663  C  C     . GLN C 2 50 ? 58.162 -5.761  27.794 1.00 28.70 ? 186 GLN A C     1 
ATOM   664  O  O     . GLN C 2 50 ? 57.578 -6.764  28.193 1.00 28.31 ? 186 GLN A O     1 
ATOM   665  C  CB    . GLN C 2 50 ? 59.411 -6.537  25.778 1.00 29.59 ? 186 GLN A CB    1 
ATOM   666  C  CG    . GLN C 2 50 ? 60.071 -5.780  24.636 1.00 32.04 ? 186 GLN A CG    1 
ATOM   667  C  CD    . GLN C 2 50 ? 60.550 -6.704  23.530 1.00 35.18 ? 186 GLN A CD    1 
ATOM   668  O  OE1   . GLN C 2 50 ? 61.645 -6.534  22.996 1.00 37.49 ? 186 GLN A OE1   1 
ATOM   669  N  NE2   . GLN C 2 50 ? 59.737 -7.701  23.198 1.00 38.08 ? 186 GLN A NE2   1 
ATOM   670  N  N     . LYS C 2 51 ? 57.661 -4.536  27.898 1.00 29.52 ? 187 LYS A N     1 
ATOM   671  C  CA    . LYS C 2 51 ? 56.307 -4.286  28.367 1.00 30.16 ? 187 LYS A CA    1 
ATOM   672  C  C     . LYS C 2 51 ? 55.389 -4.182  27.168 1.00 30.82 ? 187 LYS A C     1 
ATOM   673  O  O     . LYS C 2 51 ? 55.655 -3.415  26.249 1.00 30.38 ? 187 LYS A O     1 
ATOM   674  C  CB    . LYS C 2 51 ? 56.243 -2.985  29.177 1.00 30.67 ? 187 LYS A CB    1 
ATOM   675  C  CG    . LYS C 2 51 ? 54.823 -2.554  29.572 1.00 31.64 ? 187 LYS A CG    1 
ATOM   676  C  CD    . LYS C 2 51 ? 54.855 -1.474  30.635 1.00 33.54 ? 187 LYS A CD    1 
ATOM   677  C  CE    . LYS C 2 51 ? 53.512 -0.783  30.793 1.00 34.79 ? 187 LYS A CE    1 
ATOM   678  N  NZ    . LYS C 2 51 ? 53.394 0.426   29.929 1.00 35.98 ? 187 LYS A NZ    1 
ATOM   679  N  N     . GLU C 2 52 ? 54.310 -4.957  27.183 1.00 33.51 ? 188 GLU A N     1 
ATOM   680  C  CA    . GLU C 2 52 ? 53.213 -4.783  26.236 1.00 35.20 ? 188 GLU A CA    1 
ATOM   681  C  C     . GLU C 2 52 ? 52.087 -4.058  26.968 1.00 35.87 ? 188 GLU A C     1 
ATOM   682  O  O     . GLU C 2 52 ? 51.293 -4.674  27.677 1.00 35.84 ? 188 GLU A O     1 
ATOM   683  C  CB    . GLU C 2 52 ? 52.748 -6.133  25.686 1.00 35.93 ? 188 GLU A CB    1 
ATOM   684  C  CG    . GLU C 2 52 ? 53.674 -6.714  24.615 1.00 38.39 ? 188 GLU A CG    1 
ATOM   685  C  CD    . GLU C 2 52 ? 55.087 -6.960  25.121 1.00 41.10 ? 188 GLU A CD    1 
ATOM   686  O  OE1   . GLU C 2 52 ? 55.230 -7.651  26.155 1.00 42.93 ? 188 GLU A OE1   1 
ATOM   687  O  OE2   . GLU C 2 52 ? 56.051 -6.463  24.489 1.00 42.05 ? 188 GLU A OE2   1 
ATOM   688  N  N     . ALA C 2 53 ? 52.054 -2.737  26.817 1.00 36.96 ? 189 ALA A N     1 
ATOM   689  C  CA    . ALA C 2 53 ? 51.073 -1.889  27.503 1.00 37.33 ? 189 ALA A CA    1 
ATOM   690  C  C     . ALA C 2 53 ? 49.643 -2.366  27.258 1.00 37.57 ? 189 ALA A C     1 
ATOM   691  O  O     . ALA C 2 53 ? 49.216 -2.554  26.113 1.00 38.43 ? 189 ALA A O     1 
ATOM   692  C  CB    . ALA C 2 53 ? 51.219 -0.434  27.065 1.00 37.55 ? 189 ALA A CB    1 
ATOM   693  N  N     . GLY C 2 54 ? 48.917 -2.562  28.352 1.00 36.86 ? 190 GLY A N     1 
ATOM   694  C  CA    . GLY C 2 54 ? 47.541 -3.028  28.311 1.00 35.87 ? 190 GLY A CA    1 
ATOM   695  C  C     . GLY C 2 54 ? 46.923 -2.832  29.678 1.00 35.08 ? 190 GLY A C     1 
ATOM   696  O  O     . GLY C 2 54 ? 47.456 -2.088  30.505 1.00 35.11 ? 190 GLY A O     1 
ATOM   697  N  N     . THR C 2 55 ? 45.800 -3.495  29.916 1.00 33.92 ? 191 THR A N     1 
ATOM   698  C  CA    . THR C 2 55 ? 45.113 -3.398  31.198 1.00 33.32 ? 191 THR A CA    1 
ATOM   699  C  C     . THR C 2 55 ? 44.711 -4.809  31.662 1.00 31.43 ? 191 THR A C     1 
ATOM   700  O  O     . THR C 2 55 ? 43.618 -5.279  31.357 1.00 32.34 ? 191 THR A O     1 
ATOM   701  C  CB    . THR C 2 55 ? 43.906 -2.401  31.131 1.00 33.81 ? 191 THR A CB    1 
ATOM   702  O  OG1   . THR C 2 55 ? 43.168 -2.430  32.361 1.00 35.47 ? 191 THR A OG1   1 
ATOM   703  C  CG2   . THR C 2 55 ? 42.969 -2.702  29.957 1.00 34.71 ? 191 THR A CG2   1 
ATOM   704  N  N     . PRO C 2 56 ? 45.615 -5.505  32.386 1.00 28.84 ? 192 PRO A N     1 
ATOM   705  C  CA    . PRO C 2 56 ? 46.932 -5.052  32.839 1.00 26.99 ? 192 PRO A CA    1 
ATOM   706  C  C     . PRO C 2 56 ? 48.004 -5.242  31.776 1.00 24.82 ? 192 PRO A C     1 
ATOM   707  O  O     . PRO C 2 56 ? 47.796 -5.999  30.826 1.00 24.99 ? 192 PRO A O     1 
ATOM   708  C  CB    . PRO C 2 56 ? 47.208 -5.957  34.033 1.00 26.95 ? 192 PRO A CB    1 
ATOM   709  C  CG    . PRO C 2 56 ? 46.517 -7.234  33.687 1.00 27.98 ? 192 PRO A CG    1 
ATOM   710  C  CD    . PRO C 2 56 ? 45.349 -6.892  32.806 1.00 28.70 ? 192 PRO A CD    1 
ATOM   711  N  N     . PRO C 2 57 ? 49.152 -4.561  31.922 1.00 22.29 ? 193 PRO A N     1 
ATOM   712  C  CA    . PRO C 2 57 ? 50.223 -4.792  30.954 1.00 21.07 ? 193 PRO A CA    1 
ATOM   713  C  C     . PRO C 2 57 ? 50.818 -6.202  31.054 1.00 20.44 ? 193 PRO A C     1 
ATOM   714  O  O     . PRO C 2 57 ? 50.815 -6.809  32.128 1.00 19.89 ? 193 PRO A O     1 
ATOM   715  C  CB    . PRO C 2 57 ? 51.265 -3.716  31.307 1.00 21.34 ? 193 PRO A CB    1 
ATOM   716  C  CG    . PRO C 2 57 ? 50.549 -2.734  32.205 1.00 22.02 ? 193 PRO A CG    1 
ATOM   717  C  CD    . PRO C 2 57 ? 49.534 -3.558  32.930 1.00 21.98 ? 193 PRO A CD    1 
ATOM   718  N  N     . LEU C 2 58 ? 51.300 -6.707  29.922 1.00 20.41 ? 194 LEU A N     1 
ATOM   719  C  CA    . LEU C 2 58 ? 51.957 -8.017  29.834 1.00 20.23 ? 194 LEU A CA    1 
ATOM   720  C  C     . LEU C 2 58 ? 53.464 -7.824  29.666 1.00 19.59 ? 194 LEU A C     1 
ATOM   721  O  O     . LEU C 2 58 ? 53.919 -6.881  29.009 1.00 19.19 ? 194 LEU A O     1 
ATOM   722  C  CB    . LEU C 2 58 ? 51.382 -8.844  28.674 1.00 20.70 ? 194 LEU A CB    1 
ATOM   723  C  CG    . LEU C 2 58 ? 49.898 -9.242  28.761 1.00 21.98 ? 194 LEU A CG    1 
ATOM   724  C  CD1   . LEU C 2 58 ? 49.389 -9.732  27.408 1.00 23.59 ? 194 LEU A CD1   1 
ATOM   725  C  CD2   . LEU C 2 58 ? 49.640 -10.304 29.817 1.00 22.10 ? 194 LEU A CD2   1 
ATOM   726  N  N     . TRP C 2 59 ? 54.224 -8.721  30.287 1.00 19.36 ? 195 TRP A N     1 
ATOM   727  C  CA    . TRP C 2 59 ? 55.674 -8.605  30.390 1.00 19.28 ? 195 TRP A CA    1 
ATOM   728  C  C     . TRP C 2 59 ? 56.355 -9.875  29.890 1.00 19.68 ? 195 TRP A C     1 
ATOM   729  O  O     . TRP C 2 59 ? 55.980 -10.974 30.288 1.00 19.43 ? 195 TRP A O     1 
ATOM   730  C  CB    . TRP C 2 59 ? 56.064 -8.386  31.847 1.00 19.48 ? 195 TRP A CB    1 
ATOM   731  C  CG    . TRP C 2 59 ? 55.397 -7.206  32.456 1.00 19.61 ? 195 TRP A CG    1 
ATOM   732  C  CD1   . TRP C 2 59 ? 54.136 -7.152  32.963 1.00 19.04 ? 195 TRP A CD1   1 
ATOM   733  C  CD2   . TRP C 2 59 ? 55.954 -5.900  32.614 1.00 18.84 ? 195 TRP A CD2   1 
ATOM   734  N  NE1   . TRP C 2 59 ? 53.873 -5.891  33.431 1.00 18.22 ? 195 TRP A NE1   1 
ATOM   735  C  CE2   . TRP C 2 59 ? 54.972 -5.102  33.230 1.00 18.18 ? 195 TRP A CE2   1 
ATOM   736  C  CE3   . TRP C 2 59 ? 57.189 -5.324  32.287 1.00 20.42 ? 195 TRP A CE3   1 
ATOM   737  C  CZ2   . TRP C 2 59 ? 55.182 -3.754  33.531 1.00 18.96 ? 195 TRP A CZ2   1 
ATOM   738  C  CZ3   . TRP C 2 59 ? 57.402 -3.979  32.596 1.00 19.83 ? 195 TRP A CZ3   1 
ATOM   739  C  CH2   . TRP C 2 59 ? 56.405 -3.214  33.211 1.00 19.32 ? 195 TRP A CH2   1 
ATOM   740  N  N     . LYS C 2 60 ? 57.360 -9.713  29.031 1.00 20.76 ? 196 LYS A N     1 
ATOM   741  C  CA    . LYS C 2 60 ? 58.145 -10.836 28.515 1.00 21.59 ? 196 LYS A CA    1 
ATOM   742  C  C     . LYS C 2 60 ? 59.628 -10.493 28.477 1.00 22.16 ? 196 LYS A C     1 
ATOM   743  O  O     . LYS C 2 60 ? 60.023 -9.326  28.596 1.00 20.79 ? 196 LYS A O     1 
ATOM   744  C  CB    . LYS C 2 60 ? 57.667 -11.230 27.113 1.00 22.19 ? 196 LYS A CB    1 
ATOM   745  C  CG    . LYS C 2 60 ? 57.637 -10.090 26.108 1.00 23.99 ? 196 LYS A CG    1 
ATOM   746  C  CD    . LYS C 2 60 ? 57.082 -10.523 24.744 1.00 26.61 ? 196 LYS A CD    1 
ATOM   747  C  CE    . LYS C 2 60 ? 58.160 -11.103 23.836 1.00 28.24 ? 196 LYS A CE    1 
ATOM   748  N  NZ    . LYS C 2 60 ? 57.827 -10.949 22.382 1.00 30.80 ? 196 LYS A NZ    1 
ATOM   749  N  N     . ILE C 2 61 ? 60.444 -11.532 28.325 1.00 23.72 ? 197 ILE A N     1 
ATOM   750  C  CA    . ILE C 2 61 ? 61.883 -11.370 28.130 1.00 24.99 ? 197 ILE A CA    1 
ATOM   751  C  C     . ILE C 2 61 ? 62.089 -10.523 26.868 1.00 25.75 ? 197 ILE A C     1 
ATOM   752  O  O     . ILE C 2 61 ? 61.438 -10.763 25.840 1.00 25.81 ? 197 ILE A O     1 
ATOM   753  C  CB    . ILE C 2 61 ? 62.600 -12.738 27.967 1.00 25.01 ? 197 ILE A CB    1 
ATOM   754  C  CG1   . ILE C 2 61 ? 62.421 -13.619 29.217 1.00 25.16 ? 197 ILE A CG1   1 
ATOM   755  C  CG2   . ILE C 2 61 ? 64.091 -12.547 27.647 1.00 25.00 ? 197 ILE A CG2   1 
ATOM   756  C  CD1   . ILE C 2 61 ? 63.107 -13.107 30.465 1.00 26.72 ? 197 ILE A CD1   1 
ATOM   757  N  N     . ALA C 2 62 ? 62.981 -9.537  26.954 1.00 26.65 ? 198 ALA A N     1 
ATOM   758  C  CA    . ALA C 2 62 ? 63.228 -8.617  25.839 1.00 27.55 ? 198 ALA A CA    1 
ATOM   759  C  C     . ALA C 2 62 ? 63.969 -9.310  24.697 1.00 28.34 ? 198 ALA A C     1 
ATOM   760  O  O     . ALA C 2 62 ? 64.734 -10.244 24.927 1.00 29.59 ? 198 ALA A O     1 
ATOM   761  C  CB    . ALA C 2 62 ? 64.016 -7.415  26.309 1.00 27.98 ? 198 ALA A CB    1 
ATOM   762  N  N     . MET D 2 3  ? 38.220 12.962  57.022 1.00 34.62 ? 139 MET B N     1 
ATOM   763  C  CA    . MET D 2 3  ? 36.835 13.496  57.193 1.00 34.69 ? 139 MET B CA    1 
ATOM   764  C  C     . MET D 2 3  ? 36.480 14.573  56.154 1.00 34.10 ? 139 MET B C     1 
ATOM   765  O  O     . MET D 2 3  ? 37.218 15.538  55.950 1.00 33.42 ? 139 MET B O     1 
ATOM   766  C  CB    . MET D 2 3  ? 36.631 14.040  58.610 1.00 34.96 ? 139 MET B CB    1 
ATOM   767  C  CG    . MET D 2 3  ? 35.205 14.524  58.881 1.00 36.42 ? 139 MET B CG    1 
ATOM   768  S  SD    . MET D 2 3  ? 34.440 13.883  60.398 1.00 43.01 ? 139 MET B SD    1 
ATOM   769  C  CE    . MET D 2 3  ? 34.636 12.106  60.178 1.00 42.12 ? 139 MET B CE    1 
ATOM   770  N  N     . GLU D 2 4  ? 35.323 14.384  55.527 1.00 34.13 ? 140 GLU B N     1 
ATOM   771  C  CA    . GLU D 2 4  ? 34.808 15.284  54.494 1.00 34.53 ? 140 GLU B CA    1 
ATOM   772  C  C     . GLU D 2 4  ? 34.538 16.696  55.042 1.00 34.74 ? 140 GLU B C     1 
ATOM   773  O  O     . GLU D 2 4  ? 34.902 17.702  54.424 1.00 34.87 ? 140 GLU B O     1 
ATOM   774  C  CB    . GLU D 2 4  ? 33.517 14.699  53.903 1.00 34.39 ? 140 GLU B CB    1 
ATOM   775  C  CG    . GLU D 2 4  ? 33.701 13.352  53.199 1.00 34.67 ? 140 GLU B CG    1 
ATOM   776  C  CD    . GLU D 2 4  ? 32.446 12.850  52.473 1.00 36.42 ? 140 GLU B CD    1 
ATOM   777  O  OE1   . GLU D 2 4  ? 32.583 11.935  51.633 1.00 36.14 ? 140 GLU B OE1   1 
ATOM   778  O  OE2   . GLU D 2 4  ? 31.328 13.358  52.732 1.00 37.34 ? 140 GLU B OE2   1 
ATOM   779  N  N     . GLN D 2 5  ? 33.927 16.754  56.221 1.00 34.91 ? 141 GLN B N     1 
ATOM   780  C  CA    . GLN D 2 5  ? 33.502 18.021  56.818 1.00 34.92 ? 141 GLN B CA    1 
ATOM   781  C  C     . GLN D 2 5  ? 34.700 18.873  57.250 1.00 33.93 ? 141 GLN B C     1 
ATOM   782  O  O     . GLN D 2 5  ? 34.646 20.105  57.213 1.00 33.66 ? 141 GLN B O     1 
ATOM   783  C  CB    . GLN D 2 5  ? 32.562 17.760  58.000 1.00 35.61 ? 141 GLN B CB    1 
ATOM   784  C  CG    . GLN D 2 5  ? 31.280 16.984  57.629 1.00 37.98 ? 141 GLN B CG    1 
ATOM   785  C  CD    . GLN D 2 5  ? 31.467 15.457  57.536 1.00 42.33 ? 141 GLN B CD    1 
ATOM   786  O  OE1   . GLN D 2 5  ? 30.962 14.814  56.608 1.00 47.19 ? 141 GLN B OE1   1 
ATOM   787  N  NE2   . GLN D 2 5  ? 32.179 14.878  58.500 1.00 41.84 ? 141 GLN B NE2   1 
ATOM   788  N  N     . ARG D 2 6  ? 35.781 18.200  57.630 1.00 32.95 ? 142 ARG B N     1 
ATOM   789  C  CA    . ARG D 2 6  ? 37.038 18.855  58.008 1.00 32.36 ? 142 ARG B CA    1 
ATOM   790  C  C     . ARG D 2 6  ? 37.699 19.531  56.809 1.00 31.62 ? 142 ARG B C     1 
ATOM   791  O  O     . ARG D 2 6  ? 38.185 20.658  56.903 1.00 31.33 ? 142 ARG B O     1 
ATOM   792  C  CB    . ARG D 2 6  ? 37.999 17.824  58.609 1.00 32.54 ? 142 ARG B CB    1 
ATOM   793  C  CG    . ARG D 2 6  ? 38.893 18.364  59.701 1.00 32.89 ? 142 ARG B CG    1 
ATOM   794  C  CD    . ARG D 2 6  ? 39.283 17.278  60.705 1.00 33.41 ? 142 ARG B CD    1 
ATOM   795  N  NE    . ARG D 2 6  ? 40.700 16.920  60.659 1.00 33.91 ? 142 ARG B NE    1 
ATOM   796  C  CZ    . ARG D 2 6  ? 41.698 17.723  61.023 1.00 33.09 ? 142 ARG B CZ    1 
ATOM   797  N  NH1   . ARG D 2 6  ? 42.945 17.289  60.949 1.00 33.18 ? 142 ARG B NH1   1 
ATOM   798  N  NH2   . ARG D 2 6  ? 41.467 18.960  61.449 1.00 34.13 ? 142 ARG B NH2   1 
ATOM   799  N  N     . ILE D 2 7  ? 37.713 18.835  55.678 1.00 30.85 ? 143 ILE B N     1 
ATOM   800  C  CA    . ILE D 2 7  ? 38.260 19.408  54.454 1.00 30.19 ? 143 ILE B CA    1 
ATOM   801  C  C     . ILE D 2 7  ? 37.376 20.552  53.951 1.00 29.06 ? 143 ILE B C     1 
ATOM   802  O  O     . ILE D 2 7  ? 37.893 21.605  53.580 1.00 28.11 ? 143 ILE B O     1 
ATOM   803  C  CB    . ILE D 2 7  ? 38.480 18.324  53.366 1.00 30.35 ? 143 ILE B CB    1 
ATOM   804  C  CG1   . ILE D 2 7  ? 39.776 17.559  53.672 1.00 31.30 ? 143 ILE B CG1   1 
ATOM   805  C  CG2   . ILE D 2 7  ? 38.544 18.941  51.966 1.00 29.93 ? 143 ILE B CG2   1 
ATOM   806  C  CD1   . ILE D 2 7  ? 39.842 16.180  53.071 1.00 31.55 ? 143 ILE B CD1   1 
ATOM   807  N  N     . LEU D 2 8  ? 36.059 20.348  53.946 1.00 28.18 ? 144 LEU B N     1 
ATOM   808  C  CA    . LEU D 2 8  ? 35.131 21.382  53.478 1.00 28.19 ? 144 LEU B CA    1 
ATOM   809  C  C     . LEU D 2 8  ? 35.268 22.679  54.282 1.00 27.85 ? 144 LEU B C     1 
ATOM   810  O  O     . LEU D 2 8  ? 35.291 23.762  53.703 1.00 28.13 ? 144 LEU B O     1 
ATOM   811  C  CB    . LEU D 2 8  ? 33.677 20.889  53.500 1.00 28.42 ? 144 LEU B CB    1 
ATOM   812  C  CG    . LEU D 2 8  ? 33.247 19.886  52.419 1.00 29.06 ? 144 LEU B CG    1 
ATOM   813  C  CD1   . LEU D 2 8  ? 31.835 19.417  52.688 1.00 30.02 ? 144 LEU B CD1   1 
ATOM   814  C  CD2   . LEU D 2 8  ? 33.345 20.462  51.002 1.00 29.70 ? 144 LEU B CD2   1 
ATOM   815  N  N     . LYS D 2 9  ? 35.380 22.571  55.603 1.00 27.63 ? 145 LYS B N     1 
ATOM   816  C  CA    . LYS D 2 9  ? 35.579 23.753  56.454 1.00 27.33 ? 145 LYS B CA    1 
ATOM   817  C  C     . LYS D 2 9  ? 36.892 24.478  56.148 1.00 27.32 ? 145 LYS B C     1 
ATOM   818  O  O     . LYS D 2 9  ? 36.919 25.711  56.047 1.00 27.29 ? 145 LYS B O     1 
ATOM   819  C  CB    . LYS D 2 9  ? 35.530 23.365  57.920 1.00 27.87 ? 145 LYS B CB    1 
ATOM   820  N  N     . PHE D 2 10 ? 37.977 23.718  56.005 1.00 26.67 ? 146 PHE B N     1 
ATOM   821  C  CA    . PHE D 2 10 ? 39.292 24.311  55.762 1.00 26.92 ? 146 PHE B CA    1 
ATOM   822  C  C     . PHE D 2 10 ? 39.343 25.035  54.424 1.00 27.63 ? 146 PHE B C     1 
ATOM   823  O  O     . PHE D 2 10 ? 39.868 26.148  54.336 1.00 26.98 ? 146 PHE B O     1 
ATOM   824  C  CB    . PHE D 2 10 ? 40.403 23.257  55.818 1.00 26.75 ? 146 PHE B CB    1 
ATOM   825  C  CG    . PHE D 2 10 ? 41.782 23.833  55.670 1.00 26.17 ? 146 PHE B CG    1 
ATOM   826  C  CD1   . PHE D 2 10 ? 42.529 24.193  56.791 1.00 25.71 ? 146 PHE B CD1   1 
ATOM   827  C  CD2   . PHE D 2 10 ? 42.328 24.034  54.411 1.00 26.46 ? 146 PHE B CD2   1 
ATOM   828  C  CE1   . PHE D 2 10 ? 43.795 24.733  56.656 1.00 25.50 ? 146 PHE B CE1   1 
ATOM   829  C  CE2   . PHE D 2 10 ? 43.598 24.578  54.263 1.00 27.46 ? 146 PHE B CE2   1 
ATOM   830  C  CZ    . PHE D 2 10 ? 44.335 24.924  55.381 1.00 26.48 ? 146 PHE B CZ    1 
ATOM   831  N  N     . LEU D 2 11 ? 38.810 24.392  53.389 1.00 28.71 ? 147 LEU B N     1 
ATOM   832  C  CA    . LEU D 2 11 ? 38.771 24.982  52.050 1.00 29.97 ? 147 LEU B CA    1 
ATOM   833  C  C     . LEU D 2 11 ? 37.788 26.151  51.975 1.00 31.01 ? 147 LEU B C     1 
ATOM   834  O  O     . LEU D 2 11 ? 37.958 27.050  51.150 1.00 30.91 ? 147 LEU B O     1 
ATOM   835  C  CB    . LEU D 2 11 ? 38.429 23.923  50.998 1.00 29.92 ? 147 LEU B CB    1 
ATOM   836  C  CG    . LEU D 2 11 ? 39.560 22.949  50.639 1.00 29.99 ? 147 LEU B CG    1 
ATOM   837  C  CD1   . LEU D 2 11 ? 39.064 21.848  49.702 1.00 28.32 ? 147 LEU B CD1   1 
ATOM   838  C  CD2   . LEU D 2 11 ? 40.742 23.692  50.007 1.00 31.13 ? 147 LEU B CD2   1 
ATOM   839  N  N     . GLU D 2 12 ? 36.769 26.123  52.834 1.00 32.11 ? 148 GLU B N     1 
ATOM   840  C  CA    . GLU D 2 12 ? 35.863 27.258  53.020 1.00 33.45 ? 148 GLU B CA    1 
ATOM   841  C  C     . GLU D 2 12 ? 36.614 28.455  53.611 1.00 33.58 ? 148 GLU B C     1 
ATOM   842  O  O     . GLU D 2 12 ? 36.593 29.553  53.048 1.00 33.64 ? 148 GLU B O     1 
ATOM   843  C  CB    . GLU D 2 12 ? 34.673 26.866  53.919 1.00 33.93 ? 148 GLU B CB    1 
ATOM   844  C  CG    . GLU D 2 12 ? 33.475 26.304  53.150 1.00 35.92 ? 148 GLU B CG    1 
ATOM   845  C  CD    . GLU D 2 12 ? 32.677 25.253  53.919 1.00 39.01 ? 148 GLU B CD    1 
ATOM   846  O  OE1   . GLU D 2 12 ? 32.056 24.392  53.258 1.00 40.80 ? 148 GLU B OE1   1 
ATOM   847  O  OE2   . GLU D 2 12 ? 32.670 25.272  55.172 1.00 41.88 ? 148 GLU B OE2   1 
ATOM   848  N  N     . GLU D 2 13 ? 37.303 28.224  54.726 1.00 33.87 ? 149 GLU B N     1 
ATOM   849  C  CA    . GLU D 2 13 ? 38.051 29.283  55.414 1.00 34.53 ? 149 GLU B CA    1 
ATOM   850  C  C     . GLU D 2 13 ? 39.221 29.830  54.591 1.00 34.41 ? 149 GLU B C     1 
ATOM   851  O  O     . GLU D 2 13 ? 39.717 30.923  54.866 1.00 34.49 ? 149 GLU B O     1 
ATOM   852  C  CB    . GLU D 2 13 ? 38.557 28.788  56.774 1.00 34.95 ? 149 GLU B CB    1 
ATOM   853  C  CG    . GLU D 2 13 ? 37.441 28.510  57.789 1.00 37.48 ? 149 GLU B CG    1 
ATOM   854  C  CD    . GLU D 2 13 ? 37.925 27.736  59.013 1.00 41.45 ? 149 GLU B CD    1 
ATOM   855  O  OE1   . GLU D 2 13 ? 39.155 27.652  59.221 1.00 44.29 ? 149 GLU B OE1   1 
ATOM   856  O  OE2   . GLU D 2 13 ? 37.077 27.210  59.773 1.00 44.87 ? 149 GLU B OE2   1 
ATOM   857  N  N     . LEU D 2 14 ? 39.651 29.076  53.584 1.00 34.60 ? 150 LEU B N     1 
ATOM   858  C  CA    . LEU D 2 14 ? 40.725 29.505  52.686 1.00 34.74 ? 150 LEU B CA    1 
ATOM   859  C  C     . LEU D 2 14 ? 40.368 30.798  51.944 1.00 34.43 ? 150 LEU B C     1 
ATOM   860  O  O     . LEU D 2 14 ? 41.253 31.576  51.567 1.00 34.23 ? 150 LEU B O     1 
ATOM   861  C  CB    . LEU D 2 14 ? 41.052 28.389  51.685 1.00 34.80 ? 150 LEU B CB    1 
ATOM   862  C  CG    . LEU D 2 14 ? 42.378 28.462  50.930 1.00 35.25 ? 150 LEU B CG    1 
ATOM   863  C  CD1   . LEU D 2 14 ? 43.574 28.371  51.874 1.00 36.19 ? 150 LEU B CD1   1 
ATOM   864  C  CD2   . LEU D 2 14 ? 42.436 27.352  49.900 1.00 35.36 ? 150 LEU B CD2   1 
ATOM   865  N  N     . GLY D 2 15 ? 39.071 31.021  51.742 1.00 34.19 ? 151 GLY B N     1 
ATOM   866  C  CA    . GLY D 2 15 ? 38.576 32.256  51.134 1.00 33.53 ? 151 GLY B CA    1 
ATOM   867  C  C     . GLY D 2 15 ? 37.871 32.001  49.816 1.00 33.37 ? 151 GLY B C     1 
ATOM   868  O  O     . GLY D 2 15 ? 37.997 30.930  49.224 1.00 32.78 ? 151 GLY B O     1 
ATOM   869  N  N     . GLU D 2 16 ? 37.142 33.013  49.354 1.00 33.31 ? 152 GLU B N     1 
ATOM   870  C  CA    . GLU D 2 16 ? 36.312 32.912  48.160 1.00 33.34 ? 152 GLU B CA    1 
ATOM   871  C  C     . GLU D 2 16 ? 37.160 32.701  46.908 1.00 32.42 ? 152 GLU B C     1 
ATOM   872  O  O     . GLU D 2 16 ? 38.110 33.449  46.659 1.00 32.53 ? 152 GLU B O     1 
ATOM   873  C  CB    . GLU D 2 16 ? 35.475 34.186  48.015 1.00 34.26 ? 152 GLU B CB    1 
ATOM   874  C  CG    . GLU D 2 16 ? 34.165 34.018  47.262 1.00 36.31 ? 152 GLU B CG    1 
ATOM   875  C  CD    . GLU D 2 16 ? 33.020 34.681  48.006 1.00 41.22 ? 152 GLU B CD    1 
ATOM   876  O  OE1   . GLU D 2 16 ? 32.787 35.892  47.779 1.00 43.58 ? 152 GLU B OE1   1 
ATOM   877  O  OE2   . GLU D 2 16 ? 32.379 33.997  48.843 1.00 42.18 ? 152 GLU B OE2   1 
ATOM   878  N  N     . GLY D 2 17 ? 36.826 31.668  46.139 1.00 31.21 ? 153 GLY B N     1 
ATOM   879  C  CA    . GLY D 2 17 ? 37.555 31.344  44.904 1.00 30.37 ? 153 GLY B CA    1 
ATOM   880  C  C     . GLY D 2 17 ? 38.985 30.839  45.094 1.00 29.20 ? 153 GLY B C     1 
ATOM   881  O  O     . GLY D 2 17 ? 39.735 30.721  44.125 1.00 29.76 ? 153 GLY B O     1 
ATOM   882  N  N     . LYS D 2 18 ? 39.362 30.526  46.332 1.00 27.19 ? 154 LYS B N     1 
ATOM   883  C  CA    . LYS D 2 18 ? 40.707 30.045  46.627 1.00 25.55 ? 154 LYS B CA    1 
ATOM   884  C  C     . LYS D 2 18 ? 40.774 28.513  46.574 1.00 23.37 ? 154 LYS B C     1 
ATOM   885  O  O     . LYS D 2 18 ? 39.815 27.816  46.911 1.00 22.56 ? 154 LYS B O     1 
ATOM   886  C  CB    . LYS D 2 18 ? 41.202 30.568  47.986 1.00 26.03 ? 154 LYS B CB    1 
ATOM   887  C  CG    . LYS D 2 18 ? 42.190 31.749  47.877 1.00 28.52 ? 154 LYS B CG    1 
ATOM   888  C  CD    . LYS D 2 18 ? 41.526 33.116  47.828 1.00 30.02 ? 154 LYS B CD    1 
ATOM   889  C  CE    . LYS D 2 18 ? 41.726 33.911  49.131 1.00 33.07 ? 154 LYS B CE    1 
ATOM   890  N  NZ    . LYS D 2 18 ? 43.164 34.245  49.429 1.00 31.98 ? 154 LYS B NZ    1 
ATOM   891  N  N     . ALA D 2 19 ? 41.928 28.012  46.146 1.00 20.72 ? 155 ALA B N     1 
ATOM   892  C  CA    . ALA D 2 19 ? 42.160 26.586  45.976 1.00 19.00 ? 155 ALA B CA    1 
ATOM   893  C  C     . ALA D 2 19 ? 43.543 26.218  46.497 1.00 17.49 ? 155 ALA B C     1 
ATOM   894  O  O     . ALA D 2 19 ? 44.434 27.065  46.549 1.00 16.11 ? 155 ALA B O     1 
ATOM   895  C  CB    . ALA D 2 19 ? 42.048 26.216  44.513 1.00 18.74 ? 155 ALA B CB    1 
ATOM   896  N  N     . THR D 2 20 ? 43.711 24.957  46.887 1.00 16.59 ? 156 THR B N     1 
ATOM   897  C  CA    . THR D 2 20 ? 45.040 24.429  47.230 1.00 16.37 ? 156 THR B CA    1 
ATOM   898  C  C     . THR D 2 20 ? 45.188 22.945  46.886 1.00 15.75 ? 156 THR B C     1 
ATOM   899  O  O     . THR D 2 20 ? 44.271 22.312  46.347 1.00 16.18 ? 156 THR B O     1 
ATOM   900  C  CB    . THR D 2 20 ? 45.412 24.685  48.722 1.00 16.05 ? 156 THR B CB    1 
ATOM   901  O  OG1   . THR D 2 20 ? 46.824 24.518  48.914 1.00 14.75 ? 156 THR B OG1   1 
ATOM   902  C  CG2   . THR D 2 20 ? 44.674 23.756  49.641 1.00 17.40 ? 156 THR B CG2   1 
ATOM   903  N  N     . THR D 2 21 ? 46.353 22.400  47.211 1.00 15.82 ? 157 THR B N     1 
ATOM   904  C  CA    . THR D 2 21 ? 46.722 21.045  46.824 1.00 15.30 ? 157 THR B CA    1 
ATOM   905  C  C     . THR D 2 21 ? 46.455 20.054  47.943 1.00 15.54 ? 157 THR B C     1 
ATOM   906  O  O     . THR D 2 21 ? 46.237 20.443  49.088 1.00 14.79 ? 157 THR B O     1 
ATOM   907  C  CB    . THR D 2 21 ? 48.208 20.962  46.404 1.00 14.86 ? 157 THR B CB    1 
ATOM   908  O  OG1   . THR D 2 21 ? 49.047 21.448  47.457 1.00 13.14 ? 157 THR B OG1   1 
ATOM   909  C  CG2   . THR D 2 21 ? 48.458 21.793  45.149 1.00 15.49 ? 157 THR B CG2   1 
ATOM   910  N  N     . ALA D 2 22 ? 46.436 18.771  47.587 1.00 16.14 ? 158 ALA B N     1 
ATOM   911  C  CA    . ALA D 2 22 ? 46.300 17.700  48.573 1.00 16.55 ? 158 ALA B CA    1 
ATOM   912  C  C     . ALA D 2 22 ? 47.515 17.707  49.487 1.00 16.43 ? 158 ALA B C     1 
ATOM   913  O  O     . ALA D 2 22 ? 47.384 17.555  50.700 1.00 15.78 ? 158 ALA B O     1 
ATOM   914  C  CB    . ALA D 2 22 ? 46.141 16.328  47.895 1.00 15.49 ? 158 ALA B CB    1 
ATOM   915  N  N     . HIS D 2 23 ? 48.684 17.902  48.887 1.00 16.94 ? 159 HIS B N     1 
ATOM   916  C  CA    . HIS D 2 23 ? 49.942 18.034  49.629 1.00 17.70 ? 159 HIS B CA    1 
ATOM   917  C  C     . HIS D 2 23 ? 49.847 19.109  50.722 1.00 18.34 ? 159 HIS B C     1 
ATOM   918  O  O     . HIS D 2 23 ? 50.329 18.921  51.849 1.00 17.23 ? 159 HIS B O     1 
ATOM   919  C  CB    . HIS D 2 23 ? 51.087 18.376  48.677 1.00 17.23 ? 159 HIS B CB    1 
ATOM   920  C  CG    . HIS D 2 23 ? 52.430 18.419  49.335 1.00 17.37 ? 159 HIS B CG    1 
ATOM   921  N  ND1   . HIS D 2 23 ? 53.335 17.382  49.251 1.00 21.32 ? 159 HIS B ND1   1 
ATOM   922  C  CD2   . HIS D 2 23 ? 53.024 19.373  50.089 1.00 18.88 ? 159 HIS B CD2   1 
ATOM   923  C  CE1   . HIS D 2 23 ? 54.424 17.691  49.934 1.00 18.86 ? 159 HIS B CE1   1 
ATOM   924  N  NE2   . HIS D 2 23 ? 54.261 18.893  50.453 1.00 17.65 ? 159 HIS B NE2   1 
ATOM   925  N  N     . ASP D 2 24 ? 49.246 20.241  50.373 1.00 18.50 ? 160 ASP B N     1 
ATOM   926  C  CA    . ASP D 2 24 ? 49.087 21.342  51.320 1.00 19.48 ? 160 ASP B CA    1 
ATOM   927  C  C     . ASP D 2 24 ? 48.092 20.997  52.432 1.00 18.96 ? 160 ASP B C     1 
ATOM   928  O  O     . ASP D 2 24 ? 48.368 21.239  53.606 1.00 18.04 ? 160 ASP B O     1 
ATOM   929  C  CB    . ASP D 2 24 ? 48.644 22.595  50.584 1.00 20.34 ? 160 ASP B CB    1 
ATOM   930  C  CG    . ASP D 2 24 ? 48.539 23.795  51.492 1.00 21.90 ? 160 ASP B CG    1 
ATOM   931  O  OD1   . ASP D 2 24 ? 49.548 24.505  51.673 1.00 24.22 ? 160 ASP B OD1   1 
ATOM   932  O  OD2   . ASP D 2 24 ? 47.429 24.034  52.004 1.00 26.30 ? 160 ASP B OD2   1 
ATOM   933  N  N     . LEU D 2 25 ? 46.949 20.425  52.056 1.00 18.53 ? 161 LEU B N     1 
ATOM   934  C  CA    . LEU D 2 25 ? 45.944 19.978  53.029 1.00 18.75 ? 161 LEU B CA    1 
ATOM   935  C  C     . LEU D 2 25 ? 46.533 18.937  53.983 1.00 18.32 ? 161 LEU B C     1 
ATOM   936  O  O     . LEU D 2 25 ? 46.250 18.937  55.181 1.00 18.41 ? 161 LEU B O     1 
ATOM   937  C  CB    . LEU D 2 25 ? 44.723 19.379  52.311 1.00 19.10 ? 161 LEU B CB    1 
ATOM   938  C  CG    . LEU D 2 25 ? 43.666 20.361  51.808 1.00 20.14 ? 161 LEU B CG    1 
ATOM   939  C  CD1   . LEU D 2 25 ? 42.819 19.728  50.705 1.00 21.79 ? 161 LEU B CD1   1 
ATOM   940  C  CD2   . LEU D 2 25 ? 42.792 20.839  52.974 1.00 21.10 ? 161 LEU B CD2   1 
ATOM   941  N  N     . SER D 2 26 ? 47.332 18.042  53.417 1.00 18.45 ? 162 SER B N     1 
ATOM   942  C  CA    . SER D 2 26 ? 48.011 16.983  54.153 1.00 18.85 ? 162 SER B CA    1 
ATOM   943  C  C     . SER D 2 26 ? 48.832 17.567  55.312 1.00 18.24 ? 162 SER B C     1 
ATOM   944  O  O     . SER D 2 26 ? 48.676 17.160  56.461 1.00 16.80 ? 162 SER B O     1 
ATOM   945  C  CB    . SER D 2 26 ? 48.884 16.197  53.174 1.00 18.76 ? 162 SER B CB    1 
ATOM   946  O  OG    . SER D 2 26 ? 49.454 15.055  53.767 1.00 24.21 ? 162 SER B OG    1 
ATOM   947  N  N     . GLY D 2 27 ? 49.675 18.547  54.998 1.00 18.42 ? 163 GLY B N     1 
ATOM   948  C  CA    . GLY D 2 27 ? 50.448 19.269  56.005 1.00 18.58 ? 163 GLY B CA    1 
ATOM   949  C  C     . GLY D 2 27 ? 49.572 20.001  57.006 1.00 19.12 ? 163 GLY B C     1 
ATOM   950  O  O     . GLY D 2 27 ? 49.773 19.881  58.213 1.00 19.15 ? 163 GLY B O     1 
ATOM   951  N  N     . LYS D 2 28 ? 48.574 20.736  56.510 1.00 19.60 ? 164 LYS B N     1 
ATOM   952  C  CA    . LYS D 2 28 ? 47.807 21.654  57.356 1.00 19.98 ? 164 LYS B CA    1 
ATOM   953  C  C     . LYS D 2 28 ? 46.852 20.929  58.300 1.00 19.64 ? 164 LYS B C     1 
ATOM   954  O  O     . LYS D 2 28 ? 46.525 21.447  59.361 1.00 19.57 ? 164 LYS B O     1 
ATOM   955  C  CB    . LYS D 2 28 ? 47.023 22.665  56.506 1.00 20.40 ? 164 LYS B CB    1 
ATOM   956  C  CG    . LYS D 2 28 ? 47.250 24.105  56.930 1.00 23.51 ? 164 LYS B CG    1 
ATOM   957  C  CD    . LYS D 2 28 ? 48.510 24.683  56.311 1.00 25.59 ? 164 LYS B CD    1 
ATOM   958  C  CE    . LYS D 2 28 ? 48.671 26.149  56.649 1.00 27.32 ? 164 LYS B CE    1 
ATOM   959  N  NZ    . LYS D 2 28 ? 50.059 26.605  56.358 1.00 30.05 ? 164 LYS B NZ    1 
ATOM   960  N  N     . LEU D 2 29 ? 46.399 19.742  57.895 1.00 19.31 ? 165 LEU B N     1 
ATOM   961  C  CA    . LEU D 2 29 ? 45.503 18.924  58.705 1.00 19.18 ? 165 LEU B CA    1 
ATOM   962  C  C     . LEU D 2 29 ? 46.185 17.720  59.363 1.00 18.87 ? 165 LEU B C     1 
ATOM   963  O  O     . LEU D 2 29 ? 45.523 16.919  60.015 1.00 18.03 ? 165 LEU B O     1 
ATOM   964  C  CB    . LEU D 2 29 ? 44.315 18.445  57.858 1.00 19.53 ? 165 LEU B CB    1 
ATOM   965  C  CG    . LEU D 2 29 ? 43.417 19.535  57.261 1.00 19.51 ? 165 LEU B CG    1 
ATOM   966  C  CD1   . LEU D 2 29 ? 42.295 18.897  56.441 1.00 19.54 ? 165 LEU B CD1   1 
ATOM   967  C  CD2   . LEU D 2 29 ? 42.841 20.452  58.338 1.00 20.01 ? 165 LEU B CD2   1 
ATOM   968  N  N     . GLY D 2 30 ? 47.503 17.599  59.206 1.00 18.90 ? 166 GLY B N     1 
ATOM   969  C  CA    . GLY D 2 30 ? 48.249 16.491  59.802 1.00 18.15 ? 166 GLY B CA    1 
ATOM   970  C  C     . GLY D 2 30 ? 47.654 15.146  59.435 1.00 17.86 ? 166 GLY B C     1 
ATOM   971  O  O     . GLY D 2 30 ? 47.426 14.295  60.301 1.00 17.99 ? 166 GLY B O     1 
ATOM   972  N  N     . THR D 2 31 ? 47.403 14.957  58.144 1.00 16.76 ? 167 THR B N     1 
ATOM   973  C  CA    . THR D 2 31 ? 46.795 13.732  57.640 1.00 16.37 ? 167 THR B CA    1 
ATOM   974  C  C     . THR D 2 31 ? 47.575 13.241  56.428 1.00 15.87 ? 167 THR B C     1 
ATOM   975  O  O     . THR D 2 31 ? 47.923 14.040  55.560 1.00 15.51 ? 167 THR B O     1 
ATOM   976  C  CB    . THR D 2 31 ? 45.317 13.962  57.226 1.00 16.11 ? 167 THR B CB    1 
ATOM   977  O  OG1   . THR D 2 31 ? 44.591 14.516  58.324 1.00 16.96 ? 167 THR B OG1   1 
ATOM   978  C  CG2   . THR D 2 31 ? 44.642 12.659  56.805 1.00 14.16 ? 167 THR B CG2   1 
ATOM   979  N  N     . PRO D 2 32 ? 47.850 11.922  56.361 1.00 15.28 ? 168 PRO B N     1 
ATOM   980  C  CA    . PRO D 2 32 ? 48.486 11.363  55.174 1.00 14.99 ? 168 PRO B CA    1 
ATOM   981  C  C     . PRO D 2 32 ? 47.775 11.775  53.886 1.00 14.58 ? 168 PRO B C     1 
ATOM   982  O  O     . PRO D 2 32 ? 46.539 11.769  53.825 1.00 14.23 ? 168 PRO B O     1 
ATOM   983  C  CB    . PRO D 2 32 ? 48.377 9.843   55.402 1.00 14.70 ? 168 PRO B CB    1 
ATOM   984  C  CG    . PRO D 2 32 ? 48.335 9.686   56.829 1.00 13.99 ? 168 PRO B CG    1 
ATOM   985  C  CD    . PRO D 2 32 ? 47.602 10.877  57.371 1.00 15.06 ? 168 PRO B CD    1 
ATOM   986  N  N     . LYS D 2 33 ? 48.566 12.153  52.887 1.00 14.71 ? 169 LYS B N     1 
ATOM   987  C  CA    . LYS D 2 33 ? 48.064 12.600  51.575 1.00 14.55 ? 169 LYS B CA    1 
ATOM   988  C  C     . LYS D 2 33 ? 47.139 11.566  50.910 1.00 15.10 ? 169 LYS B C     1 
ATOM   989  O  O     . LYS D 2 33 ? 46.140 11.918  50.284 1.00 14.04 ? 169 LYS B O     1 
ATOM   990  C  CB    . LYS D 2 33 ? 49.246 12.929  50.644 1.00 13.50 ? 169 LYS B CB    1 
ATOM   991  C  CG    . LYS D 2 33 ? 48.841 13.711  49.398 1.00 12.50 ? 169 LYS B CG    1 
ATOM   992  C  CD    . LYS D 2 33 ? 50.041 14.394  48.720 1.00 12.60 ? 169 LYS B CD    1 
ATOM   993  C  CE    . LYS D 2 33 ? 51.011 13.398  48.078 1.00 9.65  ? 169 LYS B CE    1 
ATOM   994  N  NZ    . LYS D 2 33 ? 50.398 12.646  46.953 1.00 9.30  ? 169 LYS B NZ    1 
ATOM   995  N  N     . LYS D 2 34 ? 47.514 10.296  51.054 1.00 16.30 ? 170 LYS B N     1 
ATOM   996  C  CA    . LYS D 2 34 ? 46.694 9.143   50.678 1.00 17.24 ? 170 LYS B CA    1 
ATOM   997  C  C     . LYS D 2 34 ? 45.238 9.295   51.110 1.00 17.14 ? 170 LYS B C     1 
ATOM   998  O  O     . LYS D 2 34 ? 44.320 9.138   50.304 1.00 17.03 ? 170 LYS B O     1 
ATOM   999  C  CB    . LYS D 2 34 ? 47.284 7.889   51.347 1.00 18.10 ? 170 LYS B CB    1 
ATOM   1000 C  CG    . LYS D 2 34 ? 46.706 6.558   50.907 1.00 21.05 ? 170 LYS B CG    1 
ATOM   1001 C  CD    . LYS D 2 34 ? 47.090 5.442   51.883 1.00 25.63 ? 170 LYS B CD    1 
ATOM   1002 C  CE    . LYS D 2 34 ? 47.423 4.139   51.164 1.00 27.57 ? 170 LYS B CE    1 
ATOM   1003 N  NZ    . LYS D 2 34 ? 46.466 3.764   50.077 1.00 30.44 ? 170 LYS B NZ    1 
ATOM   1004 N  N     . GLU D 2 35 ? 45.046 9.601   52.391 1.00 17.43 ? 171 GLU B N     1 
ATOM   1005 C  CA    . GLU D 2 35 ? 43.714 9.753   52.989 1.00 17.65 ? 171 GLU B CA    1 
ATOM   1006 C  C     . GLU D 2 35 ? 43.049 11.039  52.519 1.00 16.85 ? 171 GLU B C     1 
ATOM   1007 O  O     . GLU D 2 35 ? 41.861 11.053  52.186 1.00 16.98 ? 171 GLU B O     1 
ATOM   1008 C  CB    . GLU D 2 35 ? 43.821 9.736   54.524 1.00 17.73 ? 171 GLU B CB    1 
ATOM   1009 C  CG    . GLU D 2 35 ? 42.479 9.867   55.272 1.00 20.68 ? 171 GLU B CG    1 
ATOM   1010 C  CD    . GLU D 2 35 ? 42.638 9.905   56.791 1.00 26.04 ? 171 GLU B CD    1 
ATOM   1011 O  OE1   . GLU D 2 35 ? 43.492 9.160   57.332 1.00 29.32 ? 171 GLU B OE1   1 
ATOM   1012 O  OE2   . GLU D 2 35 ? 41.906 10.677  57.451 1.00 28.89 ? 171 GLU B OE2   1 
ATOM   1013 N  N     . ILE D 2 36 ? 43.823 12.118  52.507 1.00 15.96 ? 172 ILE B N     1 
ATOM   1014 C  CA    . ILE D 2 36 ? 43.373 13.409  51.981 1.00 15.33 ? 172 ILE B CA    1 
ATOM   1015 C  C     . ILE D 2 36 ? 42.791 13.236  50.586 1.00 14.72 ? 172 ILE B C     1 
ATOM   1016 O  O     . ILE D 2 36 ? 41.665 13.642  50.321 1.00 14.87 ? 172 ILE B O     1 
ATOM   1017 C  CB    . ILE D 2 36 ? 44.542 14.421  51.951 1.00 14.92 ? 172 ILE B CB    1 
ATOM   1018 C  CG1   . ILE D 2 36 ? 44.934 14.830  53.382 1.00 14.56 ? 172 ILE B CG1   1 
ATOM   1019 C  CG2   . ILE D 2 36 ? 44.210 15.644  51.092 1.00 16.50 ? 172 ILE B CG2   1 
ATOM   1020 C  CD1   . ILE D 2 36 ? 43.876 15.595  54.167 1.00 14.64 ? 172 ILE B CD1   1 
ATOM   1021 N  N     . ASN D 2 37 ? 43.559 12.596  49.713 1.00 14.94 ? 173 ASN B N     1 
ATOM   1022 C  CA    . ASN D 2 37 ? 43.162 12.417  48.321 1.00 15.07 ? 173 ASN B CA    1 
ATOM   1023 C  C     . ASN D 2 37 ? 41.924 11.555  48.147 1.00 15.04 ? 173 ASN B C     1 
ATOM   1024 O  O     . ASN D 2 37 ? 41.062 11.881  47.335 1.00 14.14 ? 173 ASN B O     1 
ATOM   1025 C  CB    . ASN D 2 37 ? 44.333 11.893  47.464 1.00 14.66 ? 173 ASN B CB    1 
ATOM   1026 C  CG    . ASN D 2 37 ? 45.103 13.014  46.786 1.00 12.95 ? 173 ASN B CG    1 
ATOM   1027 O  OD1   . ASN D 2 37 ? 44.528 14.039  46.410 1.00 10.67 ? 173 ASN B OD1   1 
ATOM   1028 N  ND2   . ASN D 2 37 ? 46.400 12.817  46.602 1.00 12.09 ? 173 ASN B ND2   1 
ATOM   1029 N  N     . ARG D 2 38 ? 41.820 10.476  48.917 1.00 15.82 ? 174 ARG B N     1 
ATOM   1030 C  CA    . ARG D 2 38 ? 40.619 9.638   48.869 1.00 17.16 ? 174 ARG B CA    1 
ATOM   1031 C  C     . ARG D 2 38 ? 39.368 10.459  49.154 1.00 16.94 ? 174 ARG B C     1 
ATOM   1032 O  O     . ARG D 2 38 ? 38.351 10.317  48.472 1.00 17.44 ? 174 ARG B O     1 
ATOM   1033 C  CB    . ARG D 2 38 ? 40.711 8.471   49.852 1.00 17.98 ? 174 ARG B CB    1 
ATOM   1034 C  CG    . ARG D 2 38 ? 39.503 7.527   49.817 1.00 20.14 ? 174 ARG B CG    1 
ATOM   1035 C  CD    . ARG D 2 38 ? 39.667 6.381   50.804 1.00 25.15 ? 174 ARG B CD    1 
ATOM   1036 N  NE    . ARG D 2 38 ? 39.762 6.891   52.167 1.00 30.82 ? 174 ARG B NE    1 
ATOM   1037 C  CZ    . ARG D 2 38 ? 38.727 7.313   52.893 1.00 34.50 ? 174 ARG B CZ    1 
ATOM   1038 N  NH1   . ARG D 2 38 ? 38.929 7.777   54.125 1.00 35.48 ? 174 ARG B NH1   1 
ATOM   1039 N  NH2   . ARG D 2 38 ? 37.491 7.275   52.401 1.00 36.46 ? 174 ARG B NH2   1 
ATOM   1040 N  N     . VAL D 2 39 ? 39.457 11.322  50.153 1.00 16.98 ? 175 VAL B N     1 
ATOM   1041 C  CA    . VAL D 2 39 ? 38.336 12.157  50.556 1.00 17.56 ? 175 VAL B CA    1 
ATOM   1042 C  C     . VAL D 2 39 ? 38.033 13.240  49.516 1.00 16.86 ? 175 VAL B C     1 
ATOM   1043 O  O     . VAL D 2 39 ? 36.878 13.495  49.217 1.00 16.16 ? 175 VAL B O     1 
ATOM   1044 C  CB    . VAL D 2 39 ? 38.585 12.780  51.948 1.00 17.29 ? 175 VAL B CB    1 
ATOM   1045 C  CG1   . VAL D 2 39 ? 37.482 13.748  52.307 1.00 18.83 ? 175 VAL B CG1   1 
ATOM   1046 C  CG2   . VAL D 2 39 ? 38.654 11.679  52.989 1.00 17.91 ? 175 VAL B CG2   1 
ATOM   1047 N  N     . LEU D 2 40 ? 39.069 13.868  48.969 1.00 17.16 ? 176 LEU B N     1 
ATOM   1048 C  CA    . LEU D 2 40 ? 38.883 14.912  47.944 1.00 16.53 ? 176 LEU B CA    1 
ATOM   1049 C  C     . LEU D 2 40 ? 38.164 14.379  46.716 1.00 16.74 ? 176 LEU B C     1 
ATOM   1050 O  O     . LEU D 2 40 ? 37.194 14.982  46.246 1.00 16.14 ? 176 LEU B O     1 
ATOM   1051 C  CB    . LEU D 2 40 ? 40.225 15.515  47.530 1.00 15.99 ? 176 LEU B CB    1 
ATOM   1052 C  CG    . LEU D 2 40 ? 40.933 16.419  48.545 1.00 13.19 ? 176 LEU B CG    1 
ATOM   1053 C  CD1   . LEU D 2 40 ? 42.354 16.739  48.066 1.00 13.79 ? 176 LEU B CD1   1 
ATOM   1054 C  CD2   . LEU D 2 40 ? 40.162 17.680  48.771 1.00 10.36 ? 176 LEU B CD2   1 
ATOM   1055 N  N     . TYR D 2 41 ? 38.627 13.241  46.200 1.00 17.45 ? 177 TYR B N     1 
ATOM   1056 C  CA    . TYR D 2 41 ? 38.034 12.677  44.986 1.00 18.03 ? 177 TYR B CA    1 
ATOM   1057 C  C     . TYR D 2 41 ? 36.581 12.268  45.207 1.00 19.01 ? 177 TYR B C     1 
ATOM   1058 O  O     . TYR D 2 41 ? 35.758 12.388  44.297 1.00 19.19 ? 177 TYR B O     1 
ATOM   1059 C  CB    . TYR D 2 41 ? 38.875 11.521  44.421 1.00 17.41 ? 177 TYR B CB    1 
ATOM   1060 C  CG    . TYR D 2 41 ? 40.080 11.999  43.619 1.00 16.41 ? 177 TYR B CG    1 
ATOM   1061 C  CD1   . TYR D 2 41 ? 41.287 12.270  44.245 1.00 14.58 ? 177 TYR B CD1   1 
ATOM   1062 C  CD2   . TYR D 2 41 ? 39.997 12.204  42.240 1.00 15.44 ? 177 TYR B CD2   1 
ATOM   1063 C  CE1   . TYR D 2 41 ? 42.403 12.717  43.532 1.00 14.75 ? 177 TYR B CE1   1 
ATOM   1064 C  CE2   . TYR D 2 41 ? 41.112 12.658  41.507 1.00 15.96 ? 177 TYR B CE2   1 
ATOM   1065 C  CZ    . TYR D 2 41 ? 42.319 12.912  42.174 1.00 15.84 ? 177 TYR B CZ    1 
ATOM   1066 O  OH    . TYR D 2 41 ? 43.440 13.362  41.493 1.00 11.87 ? 177 TYR B OH    1 
ATOM   1067 N  N     . SER D 2 42 ? 36.264 11.798  46.413 1.00 19.92 ? 178 SER B N     1 
ATOM   1068 C  CA    . SER D 2 42 ? 34.891 11.411  46.744 1.00 21.13 ? 178 SER B CA    1 
ATOM   1069 C  C     . SER D 2 42 ? 33.982 12.631  46.868 1.00 21.21 ? 178 SER B C     1 
ATOM   1070 O  O     . SER D 2 42 ? 32.859 12.619  46.370 1.00 20.65 ? 178 SER B O     1 
ATOM   1071 C  CB    . SER D 2 42 ? 34.836 10.557  48.018 1.00 20.81 ? 178 SER B CB    1 
ATOM   1072 O  OG    . SER D 2 42 ? 35.777 11.015  48.969 1.00 24.08 ? 178 SER B OG    1 
ATOM   1073 N  N     . LEU D 2 43 ? 34.474 13.676  47.525 1.00 21.68 ? 179 LEU B N     1 
ATOM   1074 C  CA    . LEU D 2 43 ? 33.742 14.944  47.607 1.00 22.81 ? 179 LEU B CA    1 
ATOM   1075 C  C     . LEU D 2 43 ? 33.399 15.529  46.229 1.00 23.76 ? 179 LEU B C     1 
ATOM   1076 O  O     . LEU D 2 43 ? 32.292 16.045  46.036 1.00 23.66 ? 179 LEU B O     1 
ATOM   1077 C  CB    . LEU D 2 43 ? 34.534 15.967  48.428 1.00 22.87 ? 179 LEU B CB    1 
ATOM   1078 C  CG    . LEU D 2 43 ? 34.478 15.782  49.946 1.00 22.72 ? 179 LEU B CG    1 
ATOM   1079 C  CD1   . LEU D 2 43 ? 35.524 16.647  50.603 1.00 22.27 ? 179 LEU B CD1   1 
ATOM   1080 C  CD2   . LEU D 2 43 ? 33.084 16.120  50.484 1.00 24.02 ? 179 LEU B CD2   1 
ATOM   1081 N  N     . ALA D 2 44 ? 34.344 15.437  45.288 1.00 24.52 ? 180 ALA B N     1 
ATOM   1082 C  CA    . ALA D 2 44 ? 34.129 15.883  43.902 1.00 25.00 ? 180 ALA B CA    1 
ATOM   1083 C  C     . ALA D 2 44 ? 33.021 15.092  43.202 1.00 25.93 ? 180 ALA B C     1 
ATOM   1084 O  O     . ALA D 2 44 ? 32.131 15.680  42.573 1.00 25.88 ? 180 ALA B O     1 
ATOM   1085 C  CB    . ALA D 2 44 ? 35.420 15.801  43.100 1.00 24.54 ? 180 ALA B CB    1 
ATOM   1086 N  N     . LYS D 2 45 ? 33.079 13.764  43.306 1.00 26.44 ? 181 LYS B N     1 
ATOM   1087 C  CA    . LYS D 2 45 ? 31.958 12.909  42.894 1.00 26.95 ? 181 LYS B CA    1 
ATOM   1088 C  C     . LYS D 2 45 ? 30.624 13.403  43.466 1.00 26.94 ? 181 LYS B C     1 
ATOM   1089 O  O     . LYS D 2 45 ? 29.615 13.447  42.757 1.00 26.94 ? 181 LYS B O     1 
ATOM   1090 C  CB    . LYS D 2 45 ? 32.184 11.451  43.312 1.00 27.18 ? 181 LYS B CB    1 
ATOM   1091 C  CG    . LYS D 2 45 ? 32.733 10.548  42.207 1.00 29.76 ? 181 LYS B CG    1 
ATOM   1092 C  CD    . LYS D 2 45 ? 32.800 9.095   42.675 1.00 32.19 ? 181 LYS B CD    1 
ATOM   1093 C  CE    . LYS D 2 45 ? 33.368 8.162   41.614 1.00 33.23 ? 181 LYS B CE    1 
ATOM   1094 N  NZ    . LYS D 2 45 ? 33.187 6.728   42.005 1.00 33.72 ? 181 LYS B NZ    1 
ATOM   1095 N  N     . LYS D 2 46 ? 30.628 13.786  44.741 1.00 27.48 ? 182 LYS B N     1 
ATOM   1096 C  CA    . LYS D 2 46 ? 29.409 14.270  45.407 1.00 27.83 ? 182 LYS B CA    1 
ATOM   1097 C  C     . LYS D 2 46 ? 28.985 15.692  44.991 1.00 27.94 ? 182 LYS B C     1 
ATOM   1098 O  O     . LYS D 2 46 ? 27.912 16.159  45.375 1.00 28.09 ? 182 LYS B O     1 
ATOM   1099 C  CB    . LYS D 2 46 ? 29.557 14.178  46.930 1.00 27.74 ? 182 LYS B CB    1 
ATOM   1100 C  CG    . LYS D 2 46 ? 29.374 12.765  47.459 1.00 27.12 ? 182 LYS B CG    1 
ATOM   1101 C  CD    . LYS D 2 46 ? 29.601 12.664  48.967 1.00 27.15 ? 182 LYS B CD    1 
ATOM   1102 C  CE    . LYS D 2 46 ? 29.778 11.207  49.380 1.00 28.20 ? 182 LYS B CE    1 
ATOM   1103 N  NZ    . LYS D 2 46 ? 30.044 11.026  50.838 1.00 29.68 ? 182 LYS B NZ    1 
ATOM   1104 N  N     . GLY D 2 47 ? 29.822 16.371  44.207 1.00 27.73 ? 183 GLY B N     1 
ATOM   1105 C  CA    . GLY D 2 47 ? 29.510 17.721  43.724 1.00 27.03 ? 183 GLY B CA    1 
ATOM   1106 C  C     . GLY D 2 47 ? 29.800 18.827  44.729 1.00 26.59 ? 183 GLY B C     1 
ATOM   1107 O  O     . GLY D 2 47 ? 29.404 19.969  44.523 1.00 26.19 ? 183 GLY B O     1 
ATOM   1108 N  N     . LYS D 2 48 ? 30.514 18.495  45.801 1.00 26.21 ? 184 LYS B N     1 
ATOM   1109 C  CA    . LYS D 2 48 ? 30.814 19.453  46.864 1.00 26.34 ? 184 LYS B CA    1 
ATOM   1110 C  C     . LYS D 2 48 ? 32.115 20.228  46.617 1.00 25.67 ? 184 LYS B C     1 
ATOM   1111 O  O     . LYS D 2 48 ? 32.249 21.379  47.047 1.00 24.25 ? 184 LYS B O     1 
ATOM   1112 C  CB    . LYS D 2 48 ? 30.825 18.741  48.213 1.00 26.03 ? 184 LYS B CB    1 
ATOM   1113 C  CG    . LYS D 2 48 ? 29.462 18.121  48.545 1.00 27.41 ? 184 LYS B CG    1 
ATOM   1114 C  CD    . LYS D 2 48 ? 29.447 17.409  49.896 1.00 29.61 ? 184 LYS B CD    1 
ATOM   1115 C  CE    . LYS D 2 48 ? 28.077 16.766  50.179 1.00 30.27 ? 184 LYS B CE    1 
ATOM   1116 N  NZ    . LYS D 2 48 ? 28.014 16.052  51.498 1.00 29.81 ? 184 LYS B NZ    1 
ATOM   1117 N  N     . LEU D 2 49 ? 33.054 19.603  45.907 1.00 25.72 ? 185 LEU B N     1 
ATOM   1118 C  CA    . LEU D 2 49 ? 34.281 20.277  45.484 1.00 25.81 ? 185 LEU B CA    1 
ATOM   1119 C  C     . LEU D 2 49 ? 34.452 20.268  43.977 1.00 25.94 ? 185 LEU B C     1 
ATOM   1120 O  O     . LEU D 2 49 ? 33.927 19.407  43.270 1.00 24.57 ? 185 LEU B O     1 
ATOM   1121 C  CB    . LEU D 2 49 ? 35.516 19.606  46.082 1.00 25.84 ? 185 LEU B CB    1 
ATOM   1122 C  CG    . LEU D 2 49 ? 35.718 19.620  47.587 1.00 25.40 ? 185 LEU B CG    1 
ATOM   1123 C  CD1   . LEU D 2 49 ? 36.980 18.827  47.896 1.00 26.14 ? 185 LEU B CD1   1 
ATOM   1124 C  CD2   . LEU D 2 49 ? 35.813 21.050  48.129 1.00 24.76 ? 185 LEU B CD2   1 
ATOM   1125 N  N     . GLN D 2 50 ? 35.227 21.238  43.508 1.00 26.81 ? 186 GLN B N     1 
ATOM   1126 C  CA    . GLN D 2 50 ? 35.717 21.252  42.142 1.00 27.17 ? 186 GLN B CA    1 
ATOM   1127 C  C     . GLN D 2 50 ? 37.197 20.887  42.117 1.00 26.53 ? 186 GLN B C     1 
ATOM   1128 O  O     . GLN D 2 50 ? 37.994 21.437  42.865 1.00 26.06 ? 186 GLN B O     1 
ATOM   1129 C  CB    . GLN D 2 50 ? 35.528 22.628  41.517 1.00 27.09 ? 186 GLN B CB    1 
ATOM   1130 C  CG    . GLN D 2 50 ? 36.157 22.753  40.128 1.00 29.07 ? 186 GLN B CG    1 
ATOM   1131 C  CD    . GLN D 2 50 ? 35.281 23.526  39.192 1.00 33.66 ? 186 GLN B CD    1 
ATOM   1132 O  OE1   . GLN D 2 50 ? 34.137 23.138  38.949 1.00 35.34 ? 186 GLN B OE1   1 
ATOM   1133 N  NE2   . GLN D 2 50 ? 35.791 24.642  38.676 1.00 32.79 ? 186 GLN B NE2   1 
ATOM   1134 N  N     . LYS D 2 51 ? 37.539 19.949  41.248 1.00 26.81 ? 187 LYS B N     1 
ATOM   1135 C  CA    . LYS D 2 51 ? 38.918 19.624  40.943 1.00 27.02 ? 187 LYS B CA    1 
ATOM   1136 C  C     . LYS D 2 51 ? 39.355 20.419  39.712 1.00 26.91 ? 187 LYS B C     1 
ATOM   1137 O  O     . LYS D 2 51 ? 38.831 20.215  38.620 1.00 26.66 ? 187 LYS B O     1 
ATOM   1138 C  CB    . LYS D 2 51 ? 39.042 18.131  40.663 1.00 26.51 ? 187 LYS B CB    1 
ATOM   1139 C  CG    . LYS D 2 51 ? 40.470 17.635  40.540 1.00 26.70 ? 187 LYS B CG    1 
ATOM   1140 C  CD    . LYS D 2 51 ? 40.520 16.367  39.721 1.00 27.38 ? 187 LYS B CD    1 
ATOM   1141 C  CE    . LYS D 2 51 ? 41.947 15.918  39.499 1.00 31.23 ? 187 LYS B CE    1 
ATOM   1142 N  NZ    . LYS D 2 51 ? 42.155 15.289  38.160 1.00 30.88 ? 187 LYS B NZ    1 
ATOM   1143 N  N     . GLU D 2 52 ? 40.308 21.328  39.892 1.00 25.60 ? 188 GLU B N     1 
ATOM   1144 C  CA    . GLU D 2 52 ? 40.880 22.041  38.756 1.00 25.12 ? 188 GLU B CA    1 
ATOM   1145 C  C     . GLU D 2 52 ? 41.805 21.132  37.950 1.00 23.81 ? 188 GLU B C     1 
ATOM   1146 O  O     . GLU D 2 52 ? 42.439 20.224  38.496 1.00 23.16 ? 188 GLU B O     1 
ATOM   1147 C  CB    . GLU D 2 52 ? 41.625 23.302  39.192 1.00 24.94 ? 188 GLU B CB    1 
ATOM   1148 C  CG    . GLU D 2 52 ? 40.704 24.426  39.609 1.00 26.53 ? 188 GLU B CG    1 
ATOM   1149 C  CD    . GLU D 2 52 ? 41.444 25.675  40.063 1.00 27.83 ? 188 GLU B CD    1 
ATOM   1150 O  OE1   . GLU D 2 52 ? 42.527 25.964  39.515 1.00 30.71 ? 188 GLU B OE1   1 
ATOM   1151 O  OE2   . GLU D 2 52 ? 40.933 26.371  40.965 1.00 27.82 ? 188 GLU B OE2   1 
ATOM   1152 N  N     . ALA D 2 53 ? 41.859 21.375  36.645 1.00 22.43 ? 189 ALA B N     1 
ATOM   1153 C  CA    . ALA D 2 53 ? 42.803 20.681  35.783 1.00 22.05 ? 189 ALA B CA    1 
ATOM   1154 C  C     . ALA D 2 53 ? 44.233 21.087  36.130 1.00 21.46 ? 189 ALA B C     1 
ATOM   1155 O  O     . ALA D 2 53 ? 44.478 22.152  36.708 1.00 21.40 ? 189 ALA B O     1 
ATOM   1156 C  CB    . ALA D 2 53 ? 42.514 20.977  34.333 1.00 22.49 ? 189 ALA B CB    1 
ATOM   1157 N  N     . GLY D 2 54 ? 45.178 20.223  35.787 1.00 21.23 ? 190 GLY B N     1 
ATOM   1158 C  CA    . GLY D 2 54 ? 46.586 20.527  35.981 1.00 20.77 ? 190 GLY B CA    1 
ATOM   1159 C  C     . GLY D 2 54 ? 47.208 19.722  37.096 1.00 20.31 ? 190 GLY B C     1 
ATOM   1160 O  O     . GLY D 2 54 ? 46.543 18.914  37.748 1.00 20.33 ? 190 GLY B O     1 
ATOM   1161 N  N     . THR D 2 55 ? 48.485 19.997  37.324 1.00 20.07 ? 191 THR B N     1 
ATOM   1162 C  CA    . THR D 2 55 ? 49.369 19.166  38.126 1.00 20.53 ? 191 THR B CA    1 
ATOM   1163 C  C     . THR D 2 55 ? 50.248 20.068  39.011 1.00 19.73 ? 191 THR B C     1 
ATOM   1164 O  O     . THR D 2 55 ? 50.915 20.955  38.503 1.00 19.47 ? 191 THR B O     1 
ATOM   1165 C  CB    . THR D 2 55 ? 50.225 18.287  37.170 1.00 20.75 ? 191 THR B CB    1 
ATOM   1166 O  OG1   . THR D 2 55 ? 49.546 17.043  36.963 1.00 22.87 ? 191 THR B OG1   1 
ATOM   1167 C  CG2   . THR D 2 55 ? 51.635 18.015  37.696 1.00 22.62 ? 191 THR B CG2   1 
ATOM   1168 N  N     . PRO D 2 56 ? 50.206 19.881  40.343 1.00 19.24 ? 192 PRO B N     1 
ATOM   1169 C  CA    . PRO D 2 56 ? 49.263 19.053  41.079 1.00 18.89 ? 192 PRO B CA    1 
ATOM   1170 C  C     . PRO D 2 56 ? 47.841 19.608  41.002 1.00 18.32 ? 192 PRO B C     1 
ATOM   1171 O  O     . PRO D 2 56 ? 47.661 20.818  40.927 1.00 17.62 ? 192 PRO B O     1 
ATOM   1172 C  CB    . PRO D 2 56 ? 49.785 19.119  42.520 1.00 19.46 ? 192 PRO B CB    1 
ATOM   1173 C  CG    . PRO D 2 56 ? 50.583 20.358  42.591 1.00 18.90 ? 192 PRO B CG    1 
ATOM   1174 C  CD    . PRO D 2 56 ? 51.196 20.502  41.240 1.00 19.90 ? 192 PRO B CD    1 
ATOM   1175 N  N     . PRO D 2 57 ? 46.830 18.727  41.028 1.00 18.97 ? 193 PRO B N     1 
ATOM   1176 C  CA    . PRO D 2 57 ? 45.452 19.203  41.025 1.00 19.06 ? 193 PRO B CA    1 
ATOM   1177 C  C     . PRO D 2 57 ? 45.130 20.189  42.163 1.00 19.04 ? 193 PRO B C     1 
ATOM   1178 O  O     . PRO D 2 57 ? 45.603 20.033  43.292 1.00 18.38 ? 193 PRO B O     1 
ATOM   1179 C  CB    . PRO D 2 57 ? 44.641 17.922  41.183 1.00 18.72 ? 193 PRO B CB    1 
ATOM   1180 C  CG    . PRO D 2 57 ? 45.515 16.847  40.695 1.00 18.56 ? 193 PRO B CG    1 
ATOM   1181 C  CD    . PRO D 2 57 ? 46.899 17.259  41.039 1.00 18.56 ? 193 PRO B CD    1 
ATOM   1182 N  N     . LEU D 2 58 ? 44.338 21.205  41.836 1.00 19.00 ? 194 LEU B N     1 
ATOM   1183 C  CA    . LEU D 2 58 ? 43.843 22.154  42.820 1.00 18.55 ? 194 LEU B CA    1 
ATOM   1184 C  C     . LEU D 2 58 ? 42.374 21.859  43.149 1.00 18.14 ? 194 LEU B C     1 
ATOM   1185 O  O     . LEU D 2 58 ? 41.600 21.418  42.293 1.00 17.98 ? 194 LEU B O     1 
ATOM   1186 C  CB    . LEU D 2 58 ? 43.994 23.579  42.309 1.00 18.33 ? 194 LEU B CB    1 
ATOM   1187 C  CG    . LEU D 2 58 ? 45.406 24.164  42.202 1.00 18.16 ? 194 LEU B CG    1 
ATOM   1188 C  CD1   . LEU D 2 58 ? 45.300 25.517  41.531 1.00 18.77 ? 194 LEU B CD1   1 
ATOM   1189 C  CD2   . LEU D 2 58 ? 46.084 24.293  43.561 1.00 17.74 ? 194 LEU B CD2   1 
ATOM   1190 N  N     . TRP D 2 59 ? 42.003 22.109  44.396 1.00 17.12 ? 195 TRP B N     1 
ATOM   1191 C  CA    . TRP D 2 59 ? 40.679 21.780  44.887 1.00 17.36 ? 195 TRP B CA    1 
ATOM   1192 C  C     . TRP D 2 59 ? 40.073 22.985  45.559 1.00 17.88 ? 195 TRP B C     1 
ATOM   1193 O  O     . TRP D 2 59 ? 40.732 23.651  46.353 1.00 17.98 ? 195 TRP B O     1 
ATOM   1194 C  CB    . TRP D 2 59 ? 40.738 20.627  45.894 1.00 16.21 ? 195 TRP B CB    1 
ATOM   1195 C  CG    . TRP D 2 59 ? 41.398 19.405  45.371 1.00 15.18 ? 195 TRP B CG    1 
ATOM   1196 C  CD1   . TRP D 2 59 ? 42.738 19.160  45.330 1.00 15.41 ? 195 TRP B CD1   1 
ATOM   1197 C  CD2   . TRP D 2 59 ? 40.762 18.251  44.809 1.00 14.40 ? 195 TRP B CD2   1 
ATOM   1198 N  NE1   . TRP D 2 59 ? 42.976 17.931  44.778 1.00 15.68 ? 195 TRP B NE1   1 
ATOM   1199 C  CE2   . TRP D 2 59 ? 41.783 17.346  44.448 1.00 15.45 ? 195 TRP B CE2   1 
ATOM   1200 C  CE3   . TRP D 2 59 ? 39.429 17.898  44.567 1.00 16.09 ? 195 TRP B CE3   1 
ATOM   1201 C  CZ2   . TRP D 2 59 ? 41.517 16.100  43.873 1.00 15.83 ? 195 TRP B CZ2   1 
ATOM   1202 C  CZ3   . TRP D 2 59 ? 39.160 16.664  43.993 1.00 16.17 ? 195 TRP B CZ3   1 
ATOM   1203 C  CH2   . TRP D 2 59 ? 40.202 15.775  43.654 1.00 16.78 ? 195 TRP B CH2   1 
ATOM   1204 N  N     . LYS D 2 60 ? 38.815 23.259  45.241 1.00 19.25 ? 196 LYS B N     1 
ATOM   1205 C  CA    . LYS D 2 60 ? 38.081 24.358  45.865 1.00 20.44 ? 196 LYS B CA    1 
ATOM   1206 C  C     . LYS D 2 60 ? 36.607 24.001  46.066 1.00 20.53 ? 196 LYS B C     1 
ATOM   1207 O  O     . LYS D 2 60 ? 36.104 23.027  45.498 1.00 19.91 ? 196 LYS B O     1 
ATOM   1208 C  CB    . LYS D 2 60 ? 38.229 25.641  45.035 1.00 20.21 ? 196 LYS B CB    1 
ATOM   1209 C  CG    . LYS D 2 60 ? 37.646 25.567  43.633 1.00 23.82 ? 196 LYS B CG    1 
ATOM   1210 C  CD    . LYS D 2 60 ? 38.006 26.816  42.829 1.00 29.03 ? 196 LYS B CD    1 
ATOM   1211 C  CE    . LYS D 2 60 ? 37.310 26.841  41.466 1.00 30.78 ? 196 LYS B CE    1 
ATOM   1212 N  NZ    . LYS D 2 60 ? 35.828 26.989  41.606 1.00 34.12 ? 196 LYS B NZ    1 
ATOM   1213 N  N     . ILE D 2 61 ? 35.923 24.796  46.883 1.00 20.92 ? 197 ILE B N     1 
ATOM   1214 C  CA    . ILE D 2 61 ? 34.490 24.608  47.105 1.00 21.02 ? 197 ILE B CA    1 
ATOM   1215 C  C     . ILE D 2 61 ? 33.766 24.810  45.783 1.00 21.16 ? 197 ILE B C     1 
ATOM   1216 O  O     . ILE D 2 61 ? 34.025 25.774  45.061 1.00 19.86 ? 197 ILE B O     1 
ATOM   1217 C  CB    . ILE D 2 61 ? 33.912 25.606  48.137 1.00 21.54 ? 197 ILE B CB    1 
ATOM   1218 C  CG1   . ILE D 2 61 ? 34.569 25.431  49.514 1.00 21.71 ? 197 ILE B CG1   1 
ATOM   1219 C  CG2   . ILE D 2 61 ? 32.385 25.448  48.254 1.00 21.32 ? 197 ILE B CG2   1 
ATOM   1220 C  CD1   . ILE D 2 61 ? 34.269 24.098  50.193 1.00 22.16 ? 197 ILE B CD1   1 
ATOM   1221 N  N     . ALA D 2 62 ? 32.860 23.894  45.473 1.00 21.47 ? 198 ALA B N     1 
ATOM   1222 C  CA    . ALA D 2 62 ? 32.071 23.986  44.252 1.00 21.86 ? 198 ALA B CA    1 
ATOM   1223 C  C     . ALA D 2 62 ? 31.226 25.262  44.244 1.00 21.95 ? 198 ALA B C     1 
ATOM   1224 O  O     . ALA D 2 62 ? 30.707 25.674  45.277 1.00 20.66 ? 198 ALA B O     1 
ATOM   1225 C  CB    . ALA D 2 62 ? 31.166 22.750  44.106 1.00 21.73 ? 198 ALA B CB    1 
ATOM   1226 N  N     . VAL D 2 63 ? 31.115 25.885  43.073 1.00 22.32 ? 199 VAL B N     1 
ATOM   1227 C  CA    . VAL D 2 63 ? 30.158 26.956  42.859 1.00 23.16 ? 199 VAL B CA    1 
ATOM   1228 C  C     . VAL D 2 63 ? 28.821 26.281  42.594 1.00 24.52 ? 199 VAL B C     1 
ATOM   1229 O  O     . VAL D 2 63 ? 28.718 25.398  41.746 1.00 23.77 ? 199 VAL B O     1 
ATOM   1230 C  CB    . VAL D 2 63 ? 30.550 27.862  41.674 1.00 23.22 ? 199 VAL B CB    1 
ATOM   1231 C  CG1   . VAL D 2 63 ? 29.448 28.870  41.371 1.00 22.94 ? 199 VAL B CG1   1 
ATOM   1232 C  CG2   . VAL D 2 63 ? 31.873 28.583  41.967 1.00 22.77 ? 199 VAL B CG2   1 
ATOM   1233 N  N     . SER D 2 64 ? 27.802 26.704  43.330 1.00 26.26 ? 200 SER B N     1 
ATOM   1234 C  CA    . SER D 2 64 ? 26.523 26.019  43.368 1.00 27.97 ? 200 SER B CA    1 
ATOM   1235 C  C     . SER D 2 64 ? 25.403 26.864  42.779 1.00 28.54 ? 200 SER B C     1 
ATOM   1236 O  O     . SER D 2 64 ? 25.530 28.076  42.671 1.00 29.21 ? 200 SER B O     1 
ATOM   1237 C  CB    . SER D 2 64 ? 26.200 25.717  44.820 1.00 28.57 ? 200 SER B CB    1 
ATOM   1238 O  OG    . SER D 2 64 ? 26.520 26.857  45.607 1.00 30.57 ? 200 SER B OG    1 
ATOM   1239 N  N     . THR D 2 65 ? 24.311 26.206  42.408 1.00 29.64 ? 201 THR B N     1 
ATOM   1240 C  CA    . THR D 2 65 ? 23.083 26.874  41.980 1.00 30.34 ? 201 THR B CA    1 
ATOM   1241 C  C     . THR D 2 65 ? 22.043 26.892  43.100 1.00 31.41 ? 201 THR B C     1 
ATOM   1242 O  O     . THR D 2 65 ? 22.369 26.992  44.286 1.00 33.60 ? 201 THR B O     1 
ATOM   1243 C  CB    . THR D 2 65 ? 22.452 26.152  40.790 1.00 30.72 ? 201 THR B CB    1 
ATOM   1244 O  OG1   . THR D 2 65 ? 23.250 26.362  39.610 1.00 29.12 ? 201 THR B OG1   1 
ATOM   1245 C  CG2   . THR D 2 65 ? 21.004 26.641  40.573 1.00 30.39 ? 201 THR B CG2   1 
HETATM 1246 NA NA    . NA  E 3 .  ? 51.588 7.494   43.705 1.00 26.38 ? 162 NA  E NA    1 
HETATM 1247 NA NA    . NA  F 3 .  ? 46.989 1.464   42.330 1.00 27.87 ? 163 NA  F NA    1 
HETATM 1248 NA NA    . NA  G 3 .  ? 45.347 15.810  44.292 1.00 15.41 ? 203 NA  B NA    1 
HETATM 1249 O  O     . HOH H 4 .  ? 54.528 4.274   33.719 1.00 27.70 ? 7   HOH E O     1 
HETATM 1250 O  O     . HOH H 4 .  ? 52.222 -4.261  35.464 1.00 19.99 ? 8   HOH E O     1 
HETATM 1251 O  O     . HOH H 4 .  ? 57.985 -1.089  45.044 0.50 18.58 ? 14  HOH E O     1 
HETATM 1252 O  O     . HOH H 4 .  ? 57.809 3.416   48.054 1.00 32.78 ? 20  HOH E O     1 
HETATM 1253 O  O     . HOH H 4 .  ? 52.915 9.888   48.258 1.00 23.11 ? 21  HOH E O     1 
HETATM 1254 O  O     . HOH H 4 .  ? 55.529 10.840  45.994 1.00 27.25 ? 32  HOH E O     1 
HETATM 1255 O  O     . HOH H 4 .  ? 49.885 -4.249  38.194 1.00 22.42 ? 36  HOH E O     1 
HETATM 1256 O  O     . HOH H 4 .  ? 45.632 -3.674  39.026 1.00 23.07 ? 41  HOH E O     1 
HETATM 1257 O  O     . HOH H 4 .  ? 50.747 4.054   35.051 1.00 20.88 ? 43  HOH E O     1 
HETATM 1258 O  O     . HOH H 4 .  ? 42.426 -6.483  34.719 1.00 36.54 ? 45  HOH E O     1 
HETATM 1259 O  O     . HOH H 4 .  ? 48.734 4.864   33.537 1.00 15.89 ? 46  HOH E O     1 
HETATM 1260 O  O     . HOH H 4 .  ? 53.469 3.437   50.639 1.00 28.64 ? 47  HOH E O     1 
HETATM 1261 O  O     . HOH H 4 .  ? 46.661 6.575   34.763 1.00 20.11 ? 52  HOH E O     1 
HETATM 1262 O  O     . HOH H 4 .  ? 51.593 6.500   49.553 1.00 31.63 ? 60  HOH E O     1 
HETATM 1263 O  O     . HOH H 4 .  ? 51.320 7.439   45.932 1.00 25.82 ? 61  HOH E O     1 
HETATM 1264 O  O     . HOH H 4 .  ? 52.553 2.384   43.663 1.00 38.01 ? 62  HOH E O     1 
HETATM 1265 O  O     . HOH H 4 .  ? 59.117 2.729   42.069 1.00 26.97 ? 65  HOH E O     1 
HETATM 1266 O  O     . HOH H 4 .  ? 47.261 -1.313  38.844 1.00 9.01  ? 78  HOH E O     1 
HETATM 1267 O  O     . HOH H 4 .  ? 42.491 7.904   36.700 1.00 30.06 ? 83  HOH E O     1 
HETATM 1268 O  O     . HOH H 4 .  ? 52.515 6.937   34.449 1.00 28.89 ? 91  HOH E O     1 
HETATM 1269 O  O     . HOH H 4 .  ? 58.868 3.194   37.270 1.00 37.82 ? 100 HOH E O     1 
HETATM 1270 O  O     . HOH H 4 .  ? 40.876 -3.450  33.515 0.50 17.23 ? 103 HOH E O     1 
HETATM 1271 O  O     . HOH H 4 .  ? 43.097 -3.769  39.048 1.00 29.35 ? 108 HOH E O     1 
HETATM 1272 O  O     . HOH H 4 .  ? 37.667 -1.036  30.292 1.00 27.52 ? 119 HOH E O     1 
HETATM 1273 O  O     . HOH H 4 .  ? 58.936 4.384   40.573 1.00 24.12 ? 123 HOH E O     1 
HETATM 1274 O  O     . HOH H 4 .  ? 57.036 11.286  49.787 1.00 35.72 ? 125 HOH E O     1 
HETATM 1275 O  O     . HOH H 4 .  ? 37.489 5.484   39.223 1.00 38.57 ? 132 HOH E O     1 
HETATM 1276 O  O     . HOH H 4 .  ? 36.762 1.362   37.801 0.50 51.29 ? 142 HOH E O     1 
HETATM 1277 O  O     . HOH H 4 .  ? 44.062 7.995   34.019 1.00 43.39 ? 143 HOH E O     1 
HETATM 1278 O  O     . HOH H 4 .  ? 56.751 5.556   36.124 1.00 27.08 ? 151 HOH E O     1 
HETATM 1279 O  O     . HOH H 4 .  ? 50.160 -2.578  45.288 1.00 23.63 ? 154 HOH E O     1 
HETATM 1280 O  O     . HOH H 4 .  ? 57.006 3.442   32.357 1.00 27.83 ? 156 HOH E O     1 
HETATM 1281 O  O     . HOH I 4 .  ? 50.697 12.015  43.226 1.00 9.72  ? 164 HOH F O     1 
HETATM 1282 O  O     . HOH I 4 .  ? 48.754 14.568  45.471 1.00 12.04 ? 165 HOH F O     1 
HETATM 1283 O  O     . HOH I 4 .  ? 44.622 -1.024  41.143 1.00 20.72 ? 166 HOH F O     1 
HETATM 1284 O  O     . HOH I 4 .  ? 47.220 4.398   45.580 1.00 18.78 ? 167 HOH F O     1 
HETATM 1285 O  O     . HOH I 4 .  ? 49.147 -1.411  47.997 1.00 29.66 ? 168 HOH F O     1 
HETATM 1286 O  O     . HOH I 4 .  ? 43.244 6.087   51.378 1.00 26.55 ? 169 HOH F O     1 
HETATM 1287 O  O     . HOH I 4 .  ? 52.428 13.695  44.415 1.00 12.91 ? 170 HOH F O     1 
HETATM 1288 O  O     . HOH I 4 .  ? 37.659 -3.528  50.842 1.00 41.17 ? 171 HOH F O     1 
HETATM 1289 O  O     . HOH I 4 .  ? 49.607 4.455   43.801 1.00 24.75 ? 172 HOH F O     1 
HETATM 1290 O  O     . HOH I 4 .  ? 45.440 10.125  38.708 1.00 24.34 ? 173 HOH F O     1 
HETATM 1291 O  O     . HOH I 4 .  ? 39.865 7.274   40.198 1.00 22.74 ? 174 HOH F O     1 
HETATM 1292 O  O     . HOH I 4 .  ? 48.535 8.671   35.024 1.00 23.36 ? 175 HOH F O     1 
HETATM 1293 O  O     . HOH I 4 .  ? 48.456 5.644   47.961 1.00 33.88 ? 176 HOH F O     1 
HETATM 1294 O  O     . HOH I 4 .  ? 39.905 5.124   44.847 1.00 22.92 ? 177 HOH F O     1 
HETATM 1295 O  O     . HOH I 4 .  ? 43.873 -3.011  44.226 1.00 28.19 ? 178 HOH F O     1 
HETATM 1296 O  O     . HOH I 4 .  ? 51.603 17.560  44.896 1.00 23.89 ? 179 HOH F O     1 
HETATM 1297 O  O     . HOH I 4 .  ? 58.766 13.019  40.970 1.00 34.35 ? 180 HOH F O     1 
HETATM 1298 O  O     . HOH I 4 .  ? 46.687 10.315  35.923 1.00 25.05 ? 181 HOH F O     1 
HETATM 1299 O  O     . HOH I 4 .  ? 38.917 7.525   43.408 0.50 13.34 ? 182 HOH F O     1 
HETATM 1300 O  O     . HOH I 4 .  ? 40.097 5.347   47.147 1.00 23.89 ? 183 HOH F O     1 
HETATM 1301 O  O     . HOH I 4 .  ? 41.495 9.840   39.076 1.00 20.08 ? 184 HOH F O     1 
HETATM 1302 O  O     . HOH I 4 .  ? 54.527 13.177  43.305 1.00 31.34 ? 185 HOH F O     1 
HETATM 1303 O  O     . HOH I 4 .  ? 39.035 10.748  38.738 1.00 27.60 ? 186 HOH F O     1 
HETATM 1304 O  O     . HOH I 4 .  ? 47.875 -3.460  44.525 1.00 34.80 ? 187 HOH F O     1 
HETATM 1305 O  O     . HOH I 4 .  ? 44.112 5.248   53.527 1.00 41.34 ? 188 HOH F O     1 
HETATM 1306 O  O     . HOH I 4 .  ? 49.331 2.058   43.621 1.00 30.58 ? 189 HOH F O     1 
HETATM 1307 O  O     . HOH I 4 .  ? 48.229 2.123   46.553 1.00 22.31 ? 190 HOH F O     1 
HETATM 1308 O  O     . HOH I 4 .  ? 36.933 -0.003  50.262 0.50 30.31 ? 191 HOH F O     1 
HETATM 1309 O  O     . HOH J 4 .  ? 64.163 -15.605 22.379 1.00 21.12 ? 203 HOH A O     1 
HETATM 1310 O  O     . HOH J 4 .  ? 65.489 -17.916 19.490 1.00 30.05 ? 204 HOH A O     1 
HETATM 1311 O  O     . HOH J 4 .  ? 49.076 -6.884  36.802 1.00 11.39 ? 205 HOH A O     1 
HETATM 1312 O  O     . HOH J 4 .  ? 51.311 -4.408  46.803 1.00 21.18 ? 206 HOH A O     1 
HETATM 1313 O  O     . HOH J 4 .  ? 52.007 1.399   33.468 1.00 22.11 ? 207 HOH A O     1 
HETATM 1314 O  O     . HOH J 4 .  ? 50.776 -6.506  34.749 1.00 15.67 ? 208 HOH A O     1 
HETATM 1315 O  O     . HOH J 4 .  ? 52.116 -15.325 26.128 0.50 14.27 ? 209 HOH A O     1 
HETATM 1316 O  O     . HOH J 4 .  ? 46.197 -11.552 35.935 1.00 42.62 ? 210 HOH A O     1 
HETATM 1317 O  O     . HOH J 4 .  ? 56.764 -20.037 35.439 1.00 24.67 ? 211 HOH A O     1 
HETATM 1318 O  O     . HOH J 4 .  ? 67.259 -17.849 34.745 1.00 14.81 ? 212 HOH A O     1 
HETATM 1319 O  O     . HOH J 4 .  ? 59.014 -14.256 27.738 1.00 21.83 ? 213 HOH A O     1 
HETATM 1320 O  O     . HOH J 4 .  ? 56.791 -24.109 31.688 1.00 40.83 ? 214 HOH A O     1 
HETATM 1321 O  O     . HOH J 4 .  ? 59.585 -13.024 21.680 1.00 39.01 ? 215 HOH A O     1 
HETATM 1322 O  O     . HOH J 4 .  ? 52.594 -11.179 48.432 1.00 15.87 ? 216 HOH A O     1 
HETATM 1323 O  O     . HOH J 4 .  ? 60.038 1.048   32.407 1.00 23.56 ? 217 HOH A O     1 
HETATM 1324 O  O     . HOH J 4 .  ? 61.095 1.039   38.867 1.00 23.57 ? 218 HOH A O     1 
HETATM 1325 O  O     . HOH J 4 .  ? 51.415 -12.873 46.866 1.00 19.76 ? 219 HOH A O     1 
HETATM 1326 O  O     . HOH J 4 .  ? 49.613 -25.197 40.178 1.00 27.61 ? 220 HOH A O     1 
HETATM 1327 O  O     . HOH J 4 .  ? 49.735 -6.938  46.215 1.00 22.04 ? 221 HOH A O     1 
HETATM 1328 O  O     . HOH J 4 .  ? 65.306 -3.889  39.717 0.50 22.07 ? 222 HOH A O     1 
HETATM 1329 O  O     . HOH J 4 .  ? 47.517 -6.367  44.863 1.00 23.05 ? 223 HOH A O     1 
HETATM 1330 O  O     . HOH J 4 .  ? 60.924 -16.671 28.124 1.00 18.70 ? 224 HOH A O     1 
HETATM 1331 O  O     . HOH J 4 .  ? 57.956 0.134   30.908 0.50 11.66 ? 225 HOH A O     1 
HETATM 1332 O  O     . HOH J 4 .  ? 64.830 2.529   28.618 1.00 36.14 ? 226 HOH A O     1 
HETATM 1333 O  O     . HOH J 4 .  ? 51.594 -18.945 35.565 1.00 40.19 ? 227 HOH A O     1 
HETATM 1334 O  O     . HOH J 4 .  ? 62.944 -16.763 26.951 1.00 26.55 ? 228 HOH A O     1 
HETATM 1335 O  O     . HOH J 4 .  ? 65.905 -16.618 27.855 1.00 28.64 ? 229 HOH A O     1 
HETATM 1336 O  O     . HOH J 4 .  ? 53.775 -20.640 43.340 1.00 39.79 ? 230 HOH A O     1 
HETATM 1337 O  O     . HOH J 4 .  ? 61.314 5.493   37.965 1.00 31.95 ? 231 HOH A O     1 
HETATM 1338 O  O     . HOH J 4 .  ? 64.438 2.689   37.781 1.00 31.07 ? 232 HOH A O     1 
HETATM 1339 O  O     . HOH J 4 .  ? 62.034 -15.124 24.957 1.00 30.59 ? 233 HOH A O     1 
HETATM 1340 O  O     . HOH J 4 .  ? 46.083 -6.375  39.597 1.00 38.87 ? 234 HOH A O     1 
HETATM 1341 O  O     . HOH J 4 .  ? 42.326 -7.113  31.839 1.00 38.98 ? 235 HOH A O     1 
HETATM 1342 O  O     . HOH J 4 .  ? 58.941 -1.894  26.990 1.00 29.93 ? 236 HOH A O     1 
HETATM 1343 O  O     . HOH J 4 .  ? 59.927 -10.928 47.867 1.00 16.69 ? 237 HOH A O     1 
HETATM 1344 O  O     . HOH J 4 .  ? 43.955 -10.030 34.057 1.00 35.50 ? 238 HOH A O     1 
HETATM 1345 O  O     . HOH J 4 .  ? 53.162 -9.874  25.582 0.50 20.45 ? 239 HOH A O     1 
HETATM 1346 O  O     . HOH J 4 .  ? 56.873 -20.983 23.679 0.50 33.28 ? 240 HOH A O     1 
HETATM 1347 O  O     . HOH J 4 .  ? 66.343 -8.285  45.501 1.00 33.19 ? 241 HOH A O     1 
HETATM 1348 O  O     . HOH J 4 .  ? 68.898 -3.169  41.623 0.50 18.53 ? 242 HOH A O     1 
HETATM 1349 O  O     . HOH J 4 .  ? 63.116 2.223   40.683 1.00 29.20 ? 243 HOH A O     1 
HETATM 1350 O  O     . HOH J 4 .  ? 61.360 -4.648  49.456 1.00 37.39 ? 244 HOH A O     1 
HETATM 1351 O  O     . HOH J 4 .  ? 67.006 -12.889 31.343 1.00 30.86 ? 245 HOH A O     1 
HETATM 1352 O  O     . HOH J 4 .  ? 63.506 -6.669  45.385 1.00 38.09 ? 246 HOH A O     1 
HETATM 1353 O  O     . HOH K 4 .  ? 53.545 15.580  46.770 1.00 10.53 ? 204 HOH B O     1 
HETATM 1354 O  O     . HOH K 4 .  ? 51.530 15.237  51.492 1.00 25.67 ? 205 HOH B O     1 
HETATM 1355 O  O     . HOH K 4 .  ? 41.088 29.073  42.325 1.00 28.98 ? 206 HOH B O     1 
HETATM 1356 O  O     . HOH K 4 .  ? 50.307 8.948   51.873 1.00 9.35  ? 207 HOH B O     1 
HETATM 1357 O  O     . HOH K 4 .  ? 51.709 21.994  46.954 1.00 22.24 ? 208 HOH B O     1 
HETATM 1358 O  O     . HOH K 4 .  ? 45.262 22.350  39.222 1.00 16.49 ? 209 HOH B O     1 
HETATM 1359 O  O     . HOH K 4 .  ? 41.581 27.756  55.881 1.00 47.92 ? 210 HOH B O     1 
HETATM 1360 O  O     . HOH K 4 .  ? 47.038 17.949  44.818 1.00 12.17 ? 211 HOH B O     1 
HETATM 1361 O  O     . HOH K 4 .  ? 44.022 17.848  37.983 1.00 20.62 ? 212 HOH B O     1 
HETATM 1362 O  O     . HOH K 4 .  ? 41.604 14.992  57.789 1.00 23.08 ? 213 HOH B O     1 
HETATM 1363 O  O     . HOH K 4 .  ? 53.512 14.415  50.036 1.00 21.89 ? 214 HOH B O     1 
HETATM 1364 O  O     . HOH K 4 .  ? 37.965 8.680   46.500 1.00 25.35 ? 215 HOH B O     1 
HETATM 1365 O  O     . HOH K 4 .  ? 49.094 17.346  45.777 1.00 24.19 ? 216 HOH B O     1 
HETATM 1366 O  O     . HOH K 4 .  ? 32.293 11.989  56.994 0.50 20.66 ? 217 HOH B O     1 
HETATM 1367 O  O     . HOH K 4 .  ? 47.979 26.603  47.732 1.00 19.54 ? 218 HOH B O     1 
HETATM 1368 O  O     . HOH K 4 .  ? 36.837 27.665  47.080 1.00 25.52 ? 219 HOH B O     1 
HETATM 1369 O  O     . HOH K 4 .  ? 36.050 6.660   47.978 1.00 30.03 ? 220 HOH B O     1 
HETATM 1370 O  O     . HOH K 4 .  ? 36.783 15.640  62.770 0.50 27.19 ? 221 HOH B O     1 
HETATM 1371 O  O     . HOH K 4 .  ? 34.645 30.868  51.637 1.00 35.44 ? 222 HOH B O     1 
HETATM 1372 O  O     . HOH K 4 .  ? 44.201 13.009  39.405 1.00 23.61 ? 223 HOH B O     1 
HETATM 1373 O  O     . HOH K 4 .  ? 37.701 18.747  36.502 1.00 31.07 ? 224 HOH B O     1 
HETATM 1374 O  O     . HOH K 4 .  ? 52.856 19.891  45.704 1.00 21.14 ? 225 HOH B O     1 
HETATM 1375 O  O     . HOH K 4 .  ? 54.912 20.177  47.826 1.00 47.47 ? 226 HOH B O     1 
HETATM 1376 O  O     . HOH K 4 .  ? 31.051 16.425  40.148 1.00 30.15 ? 227 HOH B O     1 
HETATM 1377 O  O     . HOH K 4 .  ? 33.487 18.540  41.102 1.00 27.17 ? 228 HOH B O     1 
HETATM 1378 O  O     . HOH K 4 .  ? 35.950 12.590  41.851 1.00 14.51 ? 229 HOH B O     1 
HETATM 1379 O  O     . HOH K 4 .  ? 35.540 9.884   54.529 1.00 26.27 ? 230 HOH B O     1 
HETATM 1380 O  O     . HOH K 4 .  ? 52.091 22.053  49.275 1.00 35.93 ? 231 HOH B O     1 
HETATM 1381 O  O     . HOH K 4 .  ? 36.001 5.323   52.863 1.00 32.88 ? 232 HOH B O     1 
HETATM 1382 O  O     . HOH K 4 .  ? 38.657 9.583   56.903 1.00 31.28 ? 233 HOH B O     1 
HETATM 1383 O  O     . HOH K 4 .  ? 52.215 17.544  53.385 1.00 22.13 ? 234 HOH B O     1 
HETATM 1384 O  O     . HOH K 4 .  ? 28.884 23.925  46.909 1.00 29.12 ? 235 HOH B O     1 
HETATM 1385 O  O     . HOH K 4 .  ? 28.994 13.677  40.156 1.00 28.75 ? 236 HOH B O     1 
HETATM 1386 O  O     . HOH K 4 .  ? 49.575 2.898   49.910 1.00 37.05 ? 237 HOH B O     1 
HETATM 1387 O  O     . HOH K 4 .  ? 32.507 24.415  40.289 1.00 9.80  ? 238 HOH B O     1 
HETATM 1388 O  O     . HOH K 4 .  ? 28.535 12.947  52.520 1.00 39.24 ? 239 HOH B O     1 
HETATM 1389 O  O     . HOH K 4 .  ? 36.613 8.796   44.332 1.00 27.97 ? 240 HOH B O     1 
HETATM 1390 O  O     . HOH K 4 .  ? 34.205 14.247  39.959 1.00 23.76 ? 241 HOH B O     1 
HETATM 1391 O  O     . HOH K 4 .  ? 39.745 25.225  59.003 1.00 27.00 ? 242 HOH B O     1 
HETATM 1392 O  O     . HOH K 4 .  ? 50.134 21.191  34.638 1.00 28.22 ? 243 HOH B O     1 
HETATM 1393 O  O     . HOH K 4 .  ? 36.737 28.889  49.584 1.00 30.96 ? 244 HOH B O     1 
HETATM 1394 O  O     . HOH K 4 .  ? 38.813 17.903  63.738 1.00 31.20 ? 245 HOH B O     1 
HETATM 1395 O  O     . HOH K 4 .  ? 28.946 8.264   51.095 1.00 42.21 ? 246 HOH B O     1 
HETATM 1396 O  O     . HOH K 4 .  ? 53.872 11.799  49.924 1.00 22.97 ? 247 HOH B O     1 
HETATM 1397 O  O     . HOH K 4 .  ? 45.482 7.700   56.776 1.00 26.57 ? 248 HOH B O     1 
HETATM 1398 O  O     . HOH K 4 .  ? 45.008 17.691  34.516 1.00 30.69 ? 249 HOH B O     1 
HETATM 1399 O  O     . HOH K 4 .  ? 48.371 23.194  34.653 1.00 36.90 ? 250 HOH B O     1 
HETATM 1400 O  O     . HOH K 4 .  ? 28.298 28.922  45.261 1.00 25.62 ? 251 HOH B O     1 
HETATM 1401 O  O     . HOH K 4 .  ? 42.076 12.515  36.839 1.00 25.23 ? 252 HOH B O     1 
HETATM 1402 O  O     . HOH K 4 .  ? 44.938 18.057  63.237 1.00 40.21 ? 253 HOH B O     1 
HETATM 1403 O  O     . HOH K 4 .  ? 37.867 14.316  40.563 1.00 26.03 ? 254 HOH B O     1 
HETATM 1404 O  O     . HOH K 4 .  ? 34.776 7.596   55.371 1.00 30.35 ? 255 HOH B O     1 
HETATM 1405 O  O     . HOH K 4 .  ? 39.110 22.366  59.330 0.50 13.39 ? 256 HOH B O     1 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  DU  1  0   0   DU  DU  E . n 
A 1 2  C   2  1   1   C   C   E . n 
A 1 3  G   3  2   2   G   G   E . n 
A 1 4  C   4  3   3   C   C   E . n 
A 1 5  G   5  4   4   G   G   E . n 
A 1 6  C   6  5   5   C   C   E . n 
A 1 7  G   7  6   6   G   G   E . n 
B 1 1  DU  1  0   ?   ?   ?   F . n 
B 1 2  C   2  1   1   C   C   F . n 
B 1 3  G   3  2   2   G   G   F . n 
B 1 4  C   4  3   3   C   C   F . n 
B 1 5  G   5  4   4   G   G   F . n 
B 1 6  C   6  5   5   C   C   F . n 
B 1 7  G   7  6   6   G   G   F . n 
C 2 1  SER 1  137 137 SER SER A . n 
C 2 2  HIS 2  138 138 HIS HIS A . n 
C 2 3  MET 3  139 139 MET MET A . n 
C 2 4  GLU 4  140 140 GLU GLU A . n 
C 2 5  GLN 5  141 141 GLN GLN A . n 
C 2 6  ARG 6  142 142 ARG ARG A . n 
C 2 7  ILE 7  143 143 ILE ILE A . n 
C 2 8  LEU 8  144 144 LEU LEU A . n 
C 2 9  LYS 9  145 145 LYS LYS A . n 
C 2 10 PHE 10 146 146 PHE PHE A . n 
C 2 11 LEU 11 147 147 LEU LEU A . n 
C 2 12 GLU 12 148 148 GLU GLU A . n 
C 2 13 GLU 13 149 149 GLU GLU A . n 
C 2 14 LEU 14 150 150 LEU LEU A . n 
C 2 15 GLY 15 151 151 GLY GLY A . n 
C 2 16 GLU 16 152 152 GLU GLU A . n 
C 2 17 GLY 17 153 153 GLY GLY A . n 
C 2 18 LYS 18 154 154 LYS LYS A . n 
C 2 19 ALA 19 155 155 ALA ALA A . n 
C 2 20 THR 20 156 156 THR THR A . n 
C 2 21 THR 21 157 157 THR THR A . n 
C 2 22 ALA 22 158 158 ALA ALA A . n 
C 2 23 HIS 23 159 159 HIS HIS A . n 
C 2 24 ASP 24 160 160 ASP ASP A . n 
C 2 25 LEU 25 161 161 LEU LEU A . n 
C 2 26 SER 26 162 162 SER SER A . n 
C 2 27 GLY 27 163 163 GLY GLY A . n 
C 2 28 LYS 28 164 164 LYS LYS A . n 
C 2 29 LEU 29 165 165 LEU LEU A . n 
C 2 30 GLY 30 166 166 GLY GLY A . n 
C 2 31 THR 31 167 167 THR THR A . n 
C 2 32 PRO 32 168 168 PRO PRO A . n 
C 2 33 LYS 33 169 169 LYS LYS A . n 
C 2 34 LYS 34 170 170 LYS LYS A . n 
C 2 35 GLU 35 171 171 GLU GLU A . n 
C 2 36 ILE 36 172 172 ILE ILE A . n 
C 2 37 ASN 37 173 173 ASN ASN A . n 
C 2 38 ARG 38 174 174 ARG ARG A . n 
C 2 39 VAL 39 175 175 VAL VAL A . n 
C 2 40 LEU 40 176 176 LEU LEU A . n 
C 2 41 TYR 41 177 177 TYR TYR A . n 
C 2 42 SER 42 178 178 SER SER A . n 
C 2 43 LEU 43 179 179 LEU LEU A . n 
C 2 44 ALA 44 180 180 ALA ALA A . n 
C 2 45 LYS 45 181 181 LYS LYS A . n 
C 2 46 LYS 46 182 182 LYS LYS A . n 
C 2 47 GLY 47 183 183 GLY GLY A . n 
C 2 48 LYS 48 184 184 LYS LYS A . n 
C 2 49 LEU 49 185 185 LEU LEU A . n 
C 2 50 GLN 50 186 186 GLN GLN A . n 
C 2 51 LYS 51 187 187 LYS LYS A . n 
C 2 52 GLU 52 188 188 GLU GLU A . n 
C 2 53 ALA 53 189 189 ALA ALA A . n 
C 2 54 GLY 54 190 190 GLY GLY A . n 
C 2 55 THR 55 191 191 THR THR A . n 
C 2 56 PRO 56 192 192 PRO PRO A . n 
C 2 57 PRO 57 193 193 PRO PRO A . n 
C 2 58 LEU 58 194 194 LEU LEU A . n 
C 2 59 TRP 59 195 195 TRP TRP A . n 
C 2 60 LYS 60 196 196 LYS LYS A . n 
C 2 61 ILE 61 197 197 ILE ILE A . n 
C 2 62 ALA 62 198 198 ALA ALA A . n 
C 2 63 VAL 63 199 ?   ?   ?   A . n 
C 2 64 SER 64 200 ?   ?   ?   A . n 
C 2 65 THR 65 201 ?   ?   ?   A . n 
C 2 66 GLN 66 202 ?   ?   ?   A . n 
D 2 1  SER 1  137 ?   ?   ?   B . n 
D 2 2  HIS 2  138 ?   ?   ?   B . n 
D 2 3  MET 3  139 139 MET MET B . n 
D 2 4  GLU 4  140 140 GLU GLU B . n 
D 2 5  GLN 5  141 141 GLN GLN B . n 
D 2 6  ARG 6  142 142 ARG ARG B . n 
D 2 7  ILE 7  143 143 ILE ILE B . n 
D 2 8  LEU 8  144 144 LEU LEU B . n 
D 2 9  LYS 9  145 145 LYS LYS B . n 
D 2 10 PHE 10 146 146 PHE PHE B . n 
D 2 11 LEU 11 147 147 LEU LEU B . n 
D 2 12 GLU 12 148 148 GLU GLU B . n 
D 2 13 GLU 13 149 149 GLU GLU B . n 
D 2 14 LEU 14 150 150 LEU LEU B . n 
D 2 15 GLY 15 151 151 GLY GLY B . n 
D 2 16 GLU 16 152 152 GLU GLU B . n 
D 2 17 GLY 17 153 153 GLY GLY B . n 
D 2 18 LYS 18 154 154 LYS LYS B . n 
D 2 19 ALA 19 155 155 ALA ALA B . n 
D 2 20 THR 20 156 156 THR THR B . n 
D 2 21 THR 21 157 157 THR THR B . n 
D 2 22 ALA 22 158 158 ALA ALA B . n 
D 2 23 HIS 23 159 159 HIS HIS B . n 
D 2 24 ASP 24 160 160 ASP ASP B . n 
D 2 25 LEU 25 161 161 LEU LEU B . n 
D 2 26 SER 26 162 162 SER SER B . n 
D 2 27 GLY 27 163 163 GLY GLY B . n 
D 2 28 LYS 28 164 164 LYS LYS B . n 
D 2 29 LEU 29 165 165 LEU LEU B . n 
D 2 30 GLY 30 166 166 GLY GLY B . n 
D 2 31 THR 31 167 167 THR THR B . n 
D 2 32 PRO 32 168 168 PRO PRO B . n 
D 2 33 LYS 33 169 169 LYS LYS B . n 
D 2 34 LYS 34 170 170 LYS LYS B . n 
D 2 35 GLU 35 171 171 GLU GLU B . n 
D 2 36 ILE 36 172 172 ILE ILE B . n 
D 2 37 ASN 37 173 173 ASN ASN B . n 
D 2 38 ARG 38 174 174 ARG ARG B . n 
D 2 39 VAL 39 175 175 VAL VAL B . n 
D 2 40 LEU 40 176 176 LEU LEU B . n 
D 2 41 TYR 41 177 177 TYR TYR B . n 
D 2 42 SER 42 178 178 SER SER B . n 
D 2 43 LEU 43 179 179 LEU LEU B . n 
D 2 44 ALA 44 180 180 ALA ALA B . n 
D 2 45 LYS 45 181 181 LYS LYS B . n 
D 2 46 LYS 46 182 182 LYS LYS B . n 
D 2 47 GLY 47 183 183 GLY GLY B . n 
D 2 48 LYS 48 184 184 LYS LYS B . n 
D 2 49 LEU 49 185 185 LEU LEU B . n 
D 2 50 GLN 50 186 186 GLN GLN B . n 
D 2 51 LYS 51 187 187 LYS LYS B . n 
D 2 52 GLU 52 188 188 GLU GLU B . n 
D 2 53 ALA 53 189 189 ALA ALA B . n 
D 2 54 GLY 54 190 190 GLY GLY B . n 
D 2 55 THR 55 191 191 THR THR B . n 
D 2 56 PRO 56 192 192 PRO PRO B . n 
D 2 57 PRO 57 193 193 PRO PRO B . n 
D 2 58 LEU 58 194 194 LEU LEU B . n 
D 2 59 TRP 59 195 195 TRP TRP B . n 
D 2 60 LYS 60 196 196 LYS LYS B . n 
D 2 61 ILE 61 197 197 ILE ILE B . n 
D 2 62 ALA 62 198 198 ALA ALA B . n 
D 2 63 VAL 63 199 199 VAL VAL B . n 
D 2 64 SER 64 200 200 SER SER B . n 
D 2 65 THR 65 201 201 THR THR B . n 
D 2 66 GLN 66 202 ?   ?   ?   B . n 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 E HOH 142 ? H HOH . 
2 1 F HOH 191 ? I HOH . 
3 1 B HOH 221 ? K HOH . 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OP1   ? B C   4  ? F C   3   ? 1_555 NA ? G NA . ? B NA 203 ? 1_555 OD1   ? D ASN 37 ? B ASN 173 ? 1_555 86.6  ? 
2  OP1   ? B C   4  ? F C   3   ? 1_555 NA ? G NA . ? B NA 203 ? 1_555 O     ? K HOH .  ? B HOH 211 ? 1_555 132.6 ? 
3  OD1   ? D ASN 37 ? B ASN 173 ? 1_555 NA ? G NA . ? B NA 203 ? 1_555 O     ? K HOH .  ? B HOH 211 ? 1_555 120.5 ? 
4  "O2'" ? A C   6  ? E C   5   ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O     ? H HOH .  ? E HOH 61  ? 1_555 85.0  ? 
5  "O2'" ? A C   6  ? E C   5   ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 "O2'" ? B C   4  ? F C   3   ? 1_555 175.4 ? 
6  O     ? H HOH .  ? E HOH 61  ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 "O2'" ? B C   4  ? F C   3   ? 1_555 91.8  ? 
7  "O2'" ? A C   6  ? E C   5   ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O2    ? A C   6  ? E C   5   ? 1_555 84.9  ? 
8  O     ? H HOH .  ? E HOH 61  ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O2    ? A C   6  ? E C   5   ? 1_555 141.6 ? 
9  "O2'" ? B C   4  ? F C   3   ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O2    ? A C   6  ? E C   5   ? 1_555 95.6  ? 
10 "O2'" ? A C   6  ? E C   5   ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O2    ? B C   4  ? F C   3   ? 1_555 100.0 ? 
11 O     ? H HOH .  ? E HOH 61  ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O2    ? B C   4  ? F C   3   ? 1_555 133.0 ? 
12 "O2'" ? B C   4  ? F C   3   ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O2    ? B C   4  ? F C   3   ? 1_555 84.6  ? 
13 O2    ? A C   6  ? E C   5   ? 1_555 NA ? E NA . ? E NA 162 ? 1_555 O2    ? B C   4  ? F C   3   ? 1_555 85.3  ? 
14 "O2'" ? B C   6  ? F C   5   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 "O2'" ? A C   4  ? E C   3   ? 1_555 173.4 ? 
15 "O2'" ? B C   6  ? F C   5   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O2    ? B C   6  ? F C   5   ? 1_555 84.8  ? 
16 "O2'" ? A C   4  ? E C   3   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O2    ? B C   6  ? F C   5   ? 1_555 101.6 ? 
17 "O2'" ? B C   6  ? F C   5   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O2    ? A C   4  ? E C   3   ? 1_555 96.9  ? 
18 "O2'" ? A C   4  ? E C   3   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O2    ? A C   4  ? E C   3   ? 1_555 84.9  ? 
19 O2    ? B C   6  ? F C   5   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O2    ? A C   4  ? E C   3   ? 1_555 89.1  ? 
20 "O2'" ? B C   6  ? F C   5   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O     ? I HOH .  ? F HOH 189 ? 1_555 80.6  ? 
21 "O2'" ? A C   4  ? E C   3   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O     ? I HOH .  ? F HOH 189 ? 1_555 93.7  ? 
22 O2    ? B C   6  ? F C   5   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O     ? I HOH .  ? F HOH 189 ? 1_555 157.5 ? 
23 O2    ? A C   4  ? E C   3   ? 1_555 NA ? F NA . ? F NA 163 ? 1_555 O     ? I HOH .  ? F HOH 189 ? 1_555 75.8  ? 
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2007-05-01 
2 'Structure model' 1 1 2008-05-01 
3 'Structure model' 1 2 2011-07-13 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Version format compliance' 
2 3 'Structure model' 'Version format compliance' 
# 
_pdbx_phasing_MR.entry_id                     2GXB 
_pdbx_phasing_MR.method_rotation              ? 
_pdbx_phasing_MR.method_translation           ? 
_pdbx_phasing_MR.model_details                ? 
_pdbx_phasing_MR.R_factor                     0.548 
_pdbx_phasing_MR.R_rigid_body                 ? 
_pdbx_phasing_MR.correlation_coeff_Fo_to_Fc   0.350 
_pdbx_phasing_MR.correlation_coeff_Io_to_Ic   ? 
_pdbx_phasing_MR.d_res_high_rotation          ? 
_pdbx_phasing_MR.d_res_low_rotation           ? 
_pdbx_phasing_MR.d_res_high_translation       4.000 
_pdbx_phasing_MR.d_res_low_translation        15.000 
_pdbx_phasing_MR.packing                      ? 
_pdbx_phasing_MR.reflns_percent_rotation      ? 
_pdbx_phasing_MR.reflns_percent_translation   ? 
_pdbx_phasing_MR.sigma_F_rotation             ? 
_pdbx_phasing_MR.sigma_F_translation          ? 
_pdbx_phasing_MR.sigma_I_rotation             ? 
_pdbx_phasing_MR.sigma_I_translation          ? 
# 
loop_
_software.name 
_software.version 
_software.date 
_software.type 
_software.contact_author 
_software.contact_author_email 
_software.classification 
_software.location 
_software.language 
_software.citation_id 
_software.pdbx_ordinal 
SCALA       .         ?                other   'Phil Evans'      pre@mrc-lmb.cam.ac.uk    'data scaling'    
http://www.ccp4.ac.uk/dist/html/INDEX.html            Fortran_77 ? 1 
EPMR        .         ?                other   'Charles R'       crk@agouron.com          phasing           
http://www.msg.ucsf.edu/local/programs/epmr/epmr.html ?          ? 2 
REFMAC      5.2.0005  ?                program 'Murshudov, G.N.' ccp4@dl.ac.uk            refinement        
http://www.ccp4.ac.uk/main.html                       Fortran_77 ? 3 
PDB_EXTRACT 2.000     'April. 3, 2006' package PDB               sw-help@rcsb.rutgers.edu 'data extraction' 
http://pdb.rutgers.edu/software/                      C++        ? 4 
CCP4        '(SCALA)' ?                ?       ?                 ?                        'data scaling'    ? ?          ? 5 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 "O4'" E DU 0 ? ? "C4'" E DU 0 ? ? "C3'" E DU 0 ? ? 101.35 104.50 -3.15  0.40 N 
2 1 "C1'" E DU 0 ? ? "O4'" E DU 0 ? ? "C4'" E DU 0 ? ? 99.42  110.10 -10.68 1.00 N 
3 1 "O4'" E DU 0 ? ? "C1'" E DU 0 ? ? N1    E DU 0 ? ? 111.05 108.30 2.75   0.30 N 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 B LYS 145 ? CG ? D LYS 9 CG 
2 1 Y 1 B LYS 145 ? CD ? D LYS 9 CD 
3 1 Y 1 B LYS 145 ? CE ? D LYS 9 CE 
4 1 Y 1 B LYS 145 ? NZ ? D LYS 9 NZ 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 F DU  0   ? B DU  1  
2 1 Y 1 A VAL 199 ? C VAL 63 
3 1 Y 1 A SER 200 ? C SER 64 
4 1 Y 1 A THR 201 ? C THR 65 
5 1 Y 1 A GLN 202 ? C GLN 66 
6 1 Y 1 B SER 137 ? D SER 1  
7 1 Y 1 B HIS 138 ? D HIS 2  
8 1 Y 1 B GLN 202 ? D GLN 66 
# 
_ndb_struct_conf_na.entry_id   2GXB 
_ndb_struct_conf_na.feature    'z-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 A C 2 1_555 B G 7 1_555 -0.508 -0.249 0.415  -7.464 -8.269 0.067  1 E_C1:G6_F E 1 ? F 6 ? 19 1 
1 A G 3 1_555 B C 6 1_555 0.117  -0.174 -0.197 -4.098 3.576  3.183  2 E_G2:C5_F E 2 ? F 5 ? 19 1 
1 A C 4 1_555 B G 5 1_555 -0.314 -0.059 0.134  -1.484 1.487  -1.616 3 E_C3:G4_F E 3 ? F 4 ? 19 1 
1 A G 5 1_555 B C 4 1_555 0.231  -0.040 0.130  1.340  1.332  0.547  4 E_G4:C3_F E 4 ? F 3 ? 19 1 
1 A C 6 1_555 B G 3 1_555 -0.327 -0.137 -0.175 3.777  6.720  0.266  5 E_C5:G2_F E 5 ? F 2 ? 19 1 
1 A G 7 1_555 B C 2 1_555 0.430  0.019  0.532  9.485  -0.680 -0.273 6 E_G6:C1_F E 6 ? F 1 ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 A C 2 1_555 B G 7 1_555 A G 3 1_555 B C 6 1_555 0.345  5.283  3.565 4.716  2.575  -7.282  -38.231 10.876 1.189 -17.475 32.001  
-9.048  1 EE_C1G2:C5G6_FF E 1 ? F 6 ? E 2 ? F 5 ? 
1 A G 3 1_555 B C 6 1_555 A C 4 1_555 B G 5 1_555 -0.056 -1.641 3.263 -2.439 -6.235 -49.958 2.358   -0.234 3.045 7.344   -2.873  
-50.376 2 EE_G2C3:G4C5_FF E 2 ? F 5 ? E 3 ? F 4 ? 
1 A C 4 1_555 B G 5 1_555 A G 5 1_555 B C 4 1_555 0.015  5.182  3.547 0.137  -0.794 -8.090  -33.938 0.561  4.035 5.609   0.970   
-8.130  3 EE_C3G4:C3G4_FF E 3 ? F 4 ? E 4 ? F 3 ? 
1 A G 5 1_555 B C 4 1_555 A C 6 1_555 B G 3 1_555 -0.101 -1.622 3.240 1.774  -6.055 -51.056 2.269   0.000  3.044 6.994   2.049   
-51.419 4 EE_G4C5:G2C3_FF E 4 ? F 3 ? E 5 ? F 2 ? 
1 A C 6 1_555 B G 3 1_555 A G 7 1_555 B C 2 1_555 0.013  5.148  3.474 -3.241 0.670  -7.951  -35.974 -8.094 2.813 -4.579  -22.150 
-8.611  5 EE_C5G6:C1G2_FF E 5 ? F 2 ? E 6 ? F 1 ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'SODIUM ION' NA  
4 water        HOH 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 NA  1  162 162 NA  NA  E . 
F 3 NA  1  163 163 NA  NA  F . 
G 3 NA  1  203 161 NA  NA  B . 
H 4 HOH 1  7   7   HOH HOH E . 
H 4 HOH 2  8   8   HOH HOH E . 
H 4 HOH 3  14  14  HOH HOH E . 
H 4 HOH 4  20  20  HOH HOH E . 
H 4 HOH 5  21  21  HOH HOH E . 
H 4 HOH 6  32  32  HOH HOH E . 
H 4 HOH 7  36  36  HOH HOH E . 
H 4 HOH 8  41  41  HOH HOH E . 
H 4 HOH 9  43  43  HOH HOH E . 
H 4 HOH 10 45  45  HOH HOH E . 
H 4 HOH 11 46  46  HOH HOH E . 
H 4 HOH 12 47  47  HOH HOH E . 
H 4 HOH 13 52  52  HOH HOH E . 
H 4 HOH 14 60  60  HOH HOH E . 
H 4 HOH 15 61  61  HOH HOH E . 
H 4 HOH 16 62  62  HOH HOH E . 
H 4 HOH 17 65  65  HOH HOH E . 
H 4 HOH 18 78  78  HOH HOH E . 
H 4 HOH 19 83  83  HOH HOH E . 
H 4 HOH 20 91  91  HOH HOH E . 
H 4 HOH 21 100 100 HOH HOH E . 
H 4 HOH 22 103 103 HOH HOH E . 
H 4 HOH 23 108 108 HOH HOH E . 
H 4 HOH 24 119 119 HOH HOH E . 
H 4 HOH 25 123 123 HOH HOH E . 
H 4 HOH 26 125 125 HOH HOH E . 
H 4 HOH 27 132 132 HOH HOH E . 
H 4 HOH 28 142 142 HOH HOH E . 
H 4 HOH 29 143 143 HOH HOH E . 
H 4 HOH 30 151 151 HOH HOH E . 
H 4 HOH 31 154 154 HOH HOH E . 
H 4 HOH 32 156 156 HOH HOH E . 
I 4 HOH 1  164 2   HOH HOH F . 
I 4 HOH 2  165 3   HOH HOH F . 
I 4 HOH 3  166 5   HOH HOH F . 
I 4 HOH 4  167 6   HOH HOH F . 
I 4 HOH 5  168 10  HOH HOH F . 
I 4 HOH 6  169 11  HOH HOH F . 
I 4 HOH 7  170 19  HOH HOH F . 
I 4 HOH 8  171 25  HOH HOH F . 
I 4 HOH 9  172 29  HOH HOH F . 
I 4 HOH 10 173 30  HOH HOH F . 
I 4 HOH 11 174 33  HOH HOH F . 
I 4 HOH 12 175 38  HOH HOH F . 
I 4 HOH 13 176 49  HOH HOH F . 
I 4 HOH 14 177 50  HOH HOH F . 
I 4 HOH 15 178 51  HOH HOH F . 
I 4 HOH 16 179 73  HOH HOH F . 
I 4 HOH 17 180 79  HOH HOH F . 
I 4 HOH 18 181 82  HOH HOH F . 
I 4 HOH 19 182 84  HOH HOH F . 
I 4 HOH 20 183 85  HOH HOH F . 
I 4 HOH 21 184 90  HOH HOH F . 
I 4 HOH 22 185 99  HOH HOH F . 
I 4 HOH 23 186 120 HOH HOH F . 
I 4 HOH 24 187 124 HOH HOH F . 
I 4 HOH 25 188 127 HOH HOH F . 
I 4 HOH 26 189 129 HOH HOH F . 
I 4 HOH 27 190 130 HOH HOH F . 
I 4 HOH 28 191 148 HOH HOH F . 
J 4 HOH 1  203 15  HOH HOH A . 
J 4 HOH 2  204 16  HOH HOH A . 
J 4 HOH 3  205 18  HOH HOH A . 
J 4 HOH 4  206 22  HOH HOH A . 
J 4 HOH 5  207 27  HOH HOH A . 
J 4 HOH 6  208 28  HOH HOH A . 
J 4 HOH 7  209 35  HOH HOH A . 
J 4 HOH 8  210 37  HOH HOH A . 
J 4 HOH 9  211 40  HOH HOH A . 
J 4 HOH 10 212 48  HOH HOH A . 
J 4 HOH 11 213 53  HOH HOH A . 
J 4 HOH 12 214 56  HOH HOH A . 
J 4 HOH 13 215 58  HOH HOH A . 
J 4 HOH 14 216 59  HOH HOH A . 
J 4 HOH 15 217 63  HOH HOH A . 
J 4 HOH 16 218 64  HOH HOH A . 
J 4 HOH 17 219 72  HOH HOH A . 
J 4 HOH 18 220 74  HOH HOH A . 
J 4 HOH 19 221 93  HOH HOH A . 
J 4 HOH 20 222 94  HOH HOH A . 
J 4 HOH 21 223 96  HOH HOH A . 
J 4 HOH 22 224 98  HOH HOH A . 
J 4 HOH 23 225 104 HOH HOH A . 
J 4 HOH 24 226 106 HOH HOH A . 
J 4 HOH 25 227 107 HOH HOH A . 
J 4 HOH 26 228 110 HOH HOH A . 
J 4 HOH 27 229 111 HOH HOH A . 
J 4 HOH 28 230 115 HOH HOH A . 
J 4 HOH 29 231 116 HOH HOH A . 
J 4 HOH 30 232 117 HOH HOH A . 
J 4 HOH 31 233 121 HOH HOH A . 
J 4 HOH 32 234 122 HOH HOH A . 
J 4 HOH 33 235 133 HOH HOH A . 
J 4 HOH 34 236 138 HOH HOH A . 
J 4 HOH 35 237 139 HOH HOH A . 
J 4 HOH 36 238 140 HOH HOH A . 
J 4 HOH 37 239 141 HOH HOH A . 
J 4 HOH 38 240 144 HOH HOH A . 
J 4 HOH 39 241 146 HOH HOH A . 
J 4 HOH 40 242 147 HOH HOH A . 
J 4 HOH 41 243 149 HOH HOH A . 
J 4 HOH 42 244 153 HOH HOH A . 
J 4 HOH 43 245 155 HOH HOH A . 
J 4 HOH 44 246 157 HOH HOH A . 
K 4 HOH 1  204 1   HOH HOH B . 
K 4 HOH 2  205 4   HOH HOH B . 
K 4 HOH 3  206 9   HOH HOH B . 
K 4 HOH 4  207 12  HOH HOH B . 
K 4 HOH 5  208 13  HOH HOH B . 
K 4 HOH 6  209 17  HOH HOH B . 
K 4 HOH 7  210 23  HOH HOH B . 
K 4 HOH 8  211 24  HOH HOH B . 
K 4 HOH 9  212 26  HOH HOH B . 
K 4 HOH 10 213 31  HOH HOH B . 
K 4 HOH 11 214 34  HOH HOH B . 
K 4 HOH 12 215 39  HOH HOH B . 
K 4 HOH 13 216 42  HOH HOH B . 
K 4 HOH 14 217 44  HOH HOH B . 
K 4 HOH 15 218 54  HOH HOH B . 
K 4 HOH 16 219 55  HOH HOH B . 
K 4 HOH 17 220 57  HOH HOH B . 
K 4 HOH 18 221 66  HOH HOH B . 
K 4 HOH 19 222 67  HOH HOH B . 
K 4 HOH 20 223 68  HOH HOH B . 
K 4 HOH 21 224 69  HOH HOH B . 
K 4 HOH 22 225 70  HOH HOH B . 
K 4 HOH 23 226 71  HOH HOH B . 
K 4 HOH 24 227 75  HOH HOH B . 
K 4 HOH 25 228 76  HOH HOH B . 
K 4 HOH 26 229 77  HOH HOH B . 
K 4 HOH 27 230 80  HOH HOH B . 
K 4 HOH 28 231 81  HOH HOH B . 
K 4 HOH 29 232 86  HOH HOH B . 
K 4 HOH 30 233 87  HOH HOH B . 
K 4 HOH 31 234 88  HOH HOH B . 
K 4 HOH 32 235 89  HOH HOH B . 
K 4 HOH 33 236 92  HOH HOH B . 
K 4 HOH 34 237 95  HOH HOH B . 
K 4 HOH 35 238 97  HOH HOH B . 
K 4 HOH 36 239 101 HOH HOH B . 
K 4 HOH 37 240 102 HOH HOH B . 
K 4 HOH 38 241 105 HOH HOH B . 
K 4 HOH 39 242 109 HOH HOH B . 
K 4 HOH 40 243 112 HOH HOH B . 
K 4 HOH 41 244 113 HOH HOH B . 
K 4 HOH 42 245 114 HOH HOH B . 
K 4 HOH 43 246 118 HOH HOH B . 
K 4 HOH 44 247 126 HOH HOH B . 
K 4 HOH 45 248 128 HOH HOH B . 
K 4 HOH 46 249 131 HOH HOH B . 
K 4 HOH 47 250 134 HOH HOH B . 
K 4 HOH 48 251 135 HOH HOH B . 
K 4 HOH 49 252 136 HOH HOH B . 
K 4 HOH 50 253 137 HOH HOH B . 
K 4 HOH 51 254 145 HOH HOH B . 
K 4 HOH 52 255 150 HOH HOH B . 
K 4 HOH 53 256 152 HOH HOH B . 
# 
